                         SEQUENCE LISTING

<110>  MAGENTA THERAPEUTICS, INC.
 
<120>  ANTI-CD45 ANTIBODIES AND CONJUGATES THEREOF

<130>  M103034 1525WO

<150>  63/084,903
<151>  2020-09-29

<150>  63/046,046
<151>  2020-06-30

<150>  63/046,164
<151>  2020-06-30

<150>  63/015,348
<151>  2020-04-24

<150>  62/978,147
<151>  2020-02-18

<150>  62/940,742
<151>  2019-11-26

<150>  62/929,137
<151>  2019-11-01

<150>  62/929,194
<151>  2019-11-01

<150>  62/929,207
<151>  2019-11-01

<150>  62/929,288
<151>  2019-11-01

<150>  62/929,601
<151>  2019-11-01

<150>  62/929,283
<151>  2019-11-01

<150>  62/929,347
<151>  2019-11-01

<160>  161   

<170>  PatentIn version 3.5

<210>  1
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Arg Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  2

Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  3

Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  4

Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Arg Tyr Gly Glu Val 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  5
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  5

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg 
                85                  90                  95      


Arg Arg Thr Pro Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  6

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  7

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  8

Met Gln Arg Arg Arg Thr Pro Pro Phe Thr 
1               5                   10  


<210>  9
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Arg Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  10
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg 
                85                  90                  95      


Arg Arg Thr Pro Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  11
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  12

Phe Thr Phe Glu Ala Tyr Ser Met Asn 
1               5                   


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  13

Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  14

Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Glu Val 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  15
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  15

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Asn 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Trp Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  16

Arg Ser Ser Gln Ser Leu Val Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15  


<210>  17
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  17

Phe Gly Ser Ser Arg Ala Ser 
1               5           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  18

Met Gln Arg Arg Arg Thr Pro Trp Ser 
1               5                   


<210>  19
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  20
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Asn 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Trp Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  21
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ile Ser Gly Ala Thr Ile Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  22

Phe Thr Phe Gly Gly Tyr Ser Met Asn 
1               5                   


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  23

Tyr Ile Ser Ile Ser Gly Ala Thr Ile Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  24

Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Glu Val 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  25
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  25

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Asn 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  26

Arg Ser Ser Gln Ser Leu Val Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15  


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  27

Phe Gly Ser Ser Arg Ala Ser 
1               5           


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  28

Met Gln Arg Arg Arg Thr Pro Pro Phe Thr 
1               5                   10  


<210>  29
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ile Ser Gly Ala Thr Ile Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  30
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Asn 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  31
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Thr Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  32

Phe Thr Phe Glu Ala Tyr Ser Met Asn 
1               5                   


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  33

Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  34

Ala Arg Gly Gly Gln Tyr Tyr Tyr Thr Ser Ser Asp Tyr Gly Glu Val 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  35
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  35

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Asn 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Trp Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  36

Arg Ser Ser Gln Ser Leu Val Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15  


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  37

Phe Gly Ser Ser Arg Ala Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  38

Met Gln Arg Arg Arg Thr Pro Trp Ser 
1               5                   


<210>  39
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Thr Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  40
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  40

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Asn 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Trp Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  41
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Thr Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  42

Phe Thr Phe Glu Ala Tyr Ser Met Asn 
1               5                   


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  43

Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  44

Ala Arg Gly Gly Gln Tyr Tyr Tyr Thr Ser Ser Asp Tyr Gly Glu Val 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  45
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  45

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Ser 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Trp Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  46

Arg Ser Ser Gln Ser Leu Val Ser Ser Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15  


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  47

Phe Gly Ser Ser Arg Ala Ser 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  48

Met Gln Arg Arg Arg Thr Pro Trp Ser 
1               5                   


<210>  49
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Thr Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  50
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  50

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Ser 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Trp Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  51
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Thr Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  52

Phe Thr Phe Glu Ala Tyr Ser Met Asn 
1               5                   


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  53

Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  54

Ala Arg Gly Gly Gln Tyr Tyr Tyr Thr Ser Ser Asp Tyr Gly Glu Val 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  55
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  55

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Ser 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Trp Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  56

Arg Ser Ser Gln Ser Leu Val Ser Ser Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15  


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  57

Phe Gly Ser Ser Arg Ala Ser 
1               5           


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  58

Met Gln Arg Arg Arg Thr Pro Trp Ser 
1               5                   


<210>  59
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Leu Ser Gly Ala Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Thr Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  60
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  60

Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Ser 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Trp Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  61
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  61

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ile Ser Gly Ala Thr Ile Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  62

Phe Thr Phe Gly Gly Tyr Ser Met Asn 
1               5                   


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  63

Tyr Ile Ser Ile Ser Gly Ala Thr Ile Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  64

Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Glu Val 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  65
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  65

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Ser 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  66

Arg Ser Ser Gln Ser Leu Val Ser Ser Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15  


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  67

Phe Gly Ser Ser Arg Ala Ser 
1               5           


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  68

Met Gln Arg Arg Arg Thr Pro Pro Phe Thr 
1               5                   10  


<210>  69
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ile Ser Gly Ala Thr Ile Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gln Tyr Tyr Tyr Asp Ser Ser Asp Tyr Gly Glu Val 
            100                 105                 110         


Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  70
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  70

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Ser Ser 
            20                  25                  30          


Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Gly Ser Ser Arg Ala Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Arg 
                85                  90                  95      


Arg Thr Pro Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  71
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Arg Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Arg Trp Ala Gly Ala Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  72

Phe Thr Phe Asn Asn Tyr Trp Met Thr 
1               5                   


<210>  73
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  73

Ser Ile Ser Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Arg Val Lys 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  74

Ala Arg Asp Glu Arg Trp Ala Gly Ala Met Asp Ala 
1               5                   10          


<210>  75
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  75

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln His Asn Ser Arg Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  76

Lys Ala Ser Gln Asn Ile Asn Lys Asn Leu Asp 
1               5                   10      


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  77

Glu Thr Asn Asn Leu Gln Thr 
1               5           


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  78

Tyr Gln His Asn Ser Arg Phe Thr 
1               5               


<210>  79
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  79

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Arg Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Glu Arg Trp Ala Gly Ala Met Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Cys Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  80
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln His Asn Ser Arg Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  81
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Phe 
            20                  25                  30          


Trp Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Phe His His Tyr Ser Gly Gly Gly Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  82

Phe Thr Phe Thr Asn Phe Trp Met Ala 
1               5                   


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  83

Ser Ile Ser Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  84

Val Lys Phe His His Tyr Ser Gly Gly Gly Asp Ala 
1               5                   10          


<210>  85
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Asn Asn Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Ser Ser Arg Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  86

Lys Ala Ser Gln Asn Ile Asn Lys Tyr Leu Asp 
1               5                   10      


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  87

Tyr Thr Asn Asn Leu His Thr 
1               5           


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  88

Leu Gln His Ser Ser Arg Trp Thr 
1               5               


<210>  89
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Phe 
            20                  25                  30          


Trp Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Phe His His Tyr Ser Gly Gly Gly Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Cys Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  90
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Tyr Thr Asn Asn Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Ser Ser Arg Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  91
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Tyr Tyr Asp Gly Gly Gly Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  92

Phe Thr Phe Asn Asn Tyr Trp Met Thr 
1               5                   


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  93

Ser Ile Ser Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  94

Ala Arg Leu Tyr Tyr Tyr Asp Gly Gly Gly Asp Ala 
1               5                   10          


<210>  95
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  95

Gly Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  96

Lys Ala Ser Gln Asp Ile Asn Lys Tyr Leu Asp 
1               5                   10      


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  97

Asn Thr Asn Asn Leu His Thr 
1               5           


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide

<400>  98

Leu Gln His Ile Ser Arg Trp Thr 
1               5               


<210>  99
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Ser Ile Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Tyr Tyr Asp Gly Gly Gly Asp Ala Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Cys Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  100
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  100

Gly Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Asn Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Ile Ser Arg Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  101
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  101

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  102
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  102

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  103
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  103

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  104
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  104

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  105
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  105

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  106
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  106

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Cys Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Ala Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  107
<211>  1211
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser 
            100                 105                 110         


Pro Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro 
        115                 120                 125             


Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr 
    130                 135                 140                 


Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn 
145                 150                 155                 160 


Glu Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His 
                165                 170                 175     


Asn Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser 
            180                 185                 190         


Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val 
        195                 200                 205             


Glu Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr 
    210                 215                 220                 


Thr Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr 
225                 230                 235                 240 


Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn 
                245                 250                 255     


Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys 
            260                 265                 270         


Asp Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys 
        275                 280                 285             


Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe 
    290                 295                 300                 


Cys Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro 
305                 310                 315                 320 


Gln Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu 
                325                 330                 335     


Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln 
            340                 345                 350         


Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile 
        355                 360                 365             


Ile Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr 
    370                 375                 380                 


Thr Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met 
385                 390                 395                 400 


Thr Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg 
                405                 410                 415     


Asn Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr 
            420                 425                 430         


Leu Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp 
        435                 440                 445             


Leu Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly 
    450                 455                 460                 


Asp Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn 
465                 470                 475                 480 


Ser Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser 
                485                 490                 495     


Ile Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys 
            500                 505                 510         


Arg Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp 
        515                 520                 525             


Glu Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu 
    530                 535                 540                 


Glu Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala 
545                 550                 555                 560 


Glu Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu 
                565                 570                 575     


Ala Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu 
            580                 585                 590         


Pro Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala 
        595                 600                 605             


Gly Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro 
    610                 615                 620                 


Arg Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp 
625                 630                 635                 640 


Phe Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val 
                645                 650                 655     


Thr Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro 
            660                 665                 670         


Ser Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile 
        675                 680                 685             


Asn Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile 
    690                 695                 700                 


Val Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln 
705                 710                 715                 720 


Phe Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu 
                725                 730                 735     


Leu Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly 
            740                 745                 750         


Pro Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr 
        755                 760                 765             


Ile Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val 
    770                 775                 780                 


Asp Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met 
785                 790                 795                 800 


Val Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu 
                805                 810                 815     


Tyr Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro 
            820                 825                 830         


Tyr Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro 
        835                 840                 845             


Leu Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr 
    850                 855                 860                 


Gln His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser 
865                 870                 875                 880 


Asn Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu 
                885                 890                 895     


Glu Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp 
            900                 905                 910         


Asp Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile 
        915                 920                 925             


Met Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu 
    930                 935                 940                 


Lys Glu Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val 
945                 950                 955                 960 


Lys Val Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile 
                965                 970                 975     


Cys Ala Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu 
            980                 985                 990         


Val Asp Leu Lys Asp Thr Asp Lys  Ser Ser Thr Tyr Thr  Leu Arg Val 
        995                 1000                 1005             


Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp Ser Arg  Thr Val Tyr 
    1010                 1015                 1020             


Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu Gln Leu  Pro Ala Glu 
    1025                 1030                 1035             


Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val Val Lys  Gln Lys Leu 
    1040                 1045                 1050             


Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys His His  Lys Ser Thr 
    1055                 1060                 1065             


Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser Gln Gln  Thr Gly Ile 
    1070                 1075                 1080             


Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser Ala Glu  Thr Glu Glu 
    1085                 1090                 1095             


Val Val  Asp Ile Phe Gln Val  Val Lys Ala Leu Arg  Lys Ala Arg 
    1100                 1105                 1110             


Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr Gln Phe  Leu Tyr Asp 
    1115                 1120                 1125             


Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn Gly Gln  Val Lys Lys 
    1130                 1135                 1140             


Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe Asp Asn  Glu Val Asp 
    1145                 1150                 1155             


Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn Pro Leu  Gly Ala Pro 
    1160                 1165                 1170             


Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala Glu Gly  Ser Glu Pro 
    1175                 1180                 1185             


Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser Val Asn  Gly Pro Ala 
    1190                 1195                 1200             


Ser Pro  Ala Leu Asn Gln Gly  Ser 
    1205                 1210     


<210>  108
<211>  1145
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser 
        35                  40                  45              


Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys 
    50                  55                  60                  


Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr 
65                  70                  75                  80  


Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn 
                85                  90                  95      


Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu 
            100                 105                 110         


Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr 
        115                 120                 125             


Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys 
    130                 135                 140                 


Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile 
145                 150                 155                 160 


Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn 
                165                 170                 175     


Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu 
            180                 185                 190         


Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser 
        195                 200                 205             


Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile 
    210                 215                 220                 


Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg 
225                 230                 235                 240 


Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg 
                245                 250                 255     


Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp 
            260                 265                 270         


Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu 
        275                 280                 285             


Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala 
    290                 295                 300                 


Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys 
305                 310                 315                 320 


Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser 
                325                 330                 335     


Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly 
            340                 345                 350         


Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val 
        355                 360                 365             


Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln 
    370                 375                 380                 


Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr 
385                 390                 395                 400 


Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys 
                405                 410                 415     


Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala 
            420                 425                 430         


Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser 
        435                 440                 445             


Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys 
    450                 455                 460                 


Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr 
465                 470                 475                 480 


Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe 
                485                 490                 495     


Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg 
            500                 505                 510         


Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr 
        515                 520                 525             


Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser 
    530                 535                 540                 


Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys 
545                 550                 555                 560 


Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp 
                565                 570                 575     


Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg 
            580                 585                 590         


Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met 
        595                 600                 605             


Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln 
    610                 615                 620                 


His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn 
625                 630                 635                 640 


Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr 
                645                 650                 655     


Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys 
            660                 665                 670         


Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile 
        675                 680                 685             


Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly 
    690                 695                 700                 


Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val 
705                 710                 715                 720 


Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln 
                725                 730                 735     


Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn 
            740                 745                 750         


Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu 
        755                 760                 765             


His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu 
    770                 775                 780                 


Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His 
785                 790                 795                 800 


Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val 
                805                 810                 815     


Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met 
            820                 825                 830         


Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser 
        835                 840                 845             


Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser 
    850                 855                 860                 


Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu 
865                 870                 875                 880 


Thr Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val 
                885                 890                 895     


Ile Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala 
            900                 905                 910         


Gln Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp 
        915                 920                 925             


Leu Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu 
    930                 935                 940                 


Leu Arg His Ser Lys Arg Lys Asp Ser Arg Thr Val Tyr Gln Tyr Gln 
945                 950                 955                 960 


Tyr Thr Asn Trp Ser Val Glu Gln Leu Pro Ala Glu Pro Lys Glu Leu 
                965                 970                 975     


Ile Ser Met Ile Gln Val Val Lys Gln Lys Leu Pro Gln Lys Asn Ser 
            980                 985                 990         


Ser Glu Gly Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 
        995                 1000                 1005             


Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 
    1010                 1015                 1020             


Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 
    1025                 1030                 1035             


Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 
    1040                 1045                 1050             


Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val Ile Ala  Ser Thr Tyr 
    1055                 1060                 1065             


Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 
    1070                 1075                 1080             


Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 
    1085                 1090                 1095             


Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu Lys Leu  Pro Glu Ala 
    1100                 1105                 1110             


Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 
    1115                 1120                 1125             


Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 
    1130                 1135                 1140             


Gly Ser  
    1145 


<210>  109
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp 
        35                  40                  45              


Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 
65                  70                  75                  80  


Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly 
                85                  90                  95      


Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro 
            100                 105                 110         


Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn 
        115                 120                 125             


Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val 
    130                 135                 140                 


Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr 
145                 150                 155                 160 


Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala 
                165                 170                 175     


Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe 
            180                 185                 190         


Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys 
        195                 200                 205             


Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile 
    210                 215                 220                 


Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile 
225                 230                 235                 240 


Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu 
                245                 250                 255     


Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys 
            260                 265                 270         


Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser 
        275                 280                 285             


Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser 
    290                 295                 300                 


Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys 
305                 310                 315                 320 


Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys 
                325                 330                 335     


Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys 
            340                 345                 350         


Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser 
        355                 360                 365             


Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp 
    370                 375                 380                 


Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro 
385                 390                 395                 400 


His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg 
                405                 410                 415     


Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr 
            420                 425                 430         


Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro 
        435                 440                 445             


Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala 
    450                 455                 460                 


Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu 
465                 470                 475                 480 


Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys 
                485                 490                 495     


Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln 
            500                 505                 510         


Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr 
        515                 520                 525             


Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln 
    530                 535                 540                 


Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys 
545                 550                 555                 560 


Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp 
                565                 570                 575     


Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn 
            580                 585                 590         


Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr 
        595                 600                 605             


Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg 
    610                 615                 620                 


Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys 
625                 630                 635                 640 


Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu 
                645                 650                 655     


Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His 
            660                 665                 670         


Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys 
        675                 680                 685             


Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser 
    690                 695                 700                 


Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu 
705                 710                 715                 720 


Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val 
                725                 730                 735     


Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 
            740                 745                 750         


Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 
        755                 760                 765             


Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 
    770                 775                 780                 


Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 
785                 790                 795                 800 


Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 
                805                 810                 815     


Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 
            820                 825                 830         


Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 
        835                 840                 845             


Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 
    850                 855                 860                 


Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 
865                 870                 875                 880 


Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp 
                885                 890                 895     


Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr 
            900                 905                 910         


Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr 
        915                 920                 925             


Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile 
    930                 935                 940                 


Val Met Leu Thr Glu Leu Lys His Gly Asp Gln Glu Ile Cys Ala Gln 
945                 950                 955                 960 


Tyr Trp Gly Glu Gly Lys Gln Thr Tyr Gly Asp Ile Glu Val Asp Leu 
                965                 970                 975     


Lys Asp Thr Asp Lys Ser Ser Thr Tyr Thr Leu Arg Val Phe Glu Leu 
            980                 985                 990         


Arg His Ser Lys Arg Lys Asp Ser  Arg Thr Val Tyr Gln  Tyr Gln Tyr 
        995                 1000                 1005             


Thr Asn  Trp Ser Val Glu Gln  Leu Pro Ala Glu Pro  Lys Glu Leu 
    1010                 1015                 1020             


Ile Ser  Met Ile Gln Val Val  Lys Gln Lys Leu Pro  Gln Lys Asn 
    1025                 1030                 1035             


Ser Ser  Glu Gly Asn Lys His  His Lys Ser Thr Pro  Leu Leu Ile 
    1040                 1045                 1050             


His Cys  Arg Asp Gly Ser Gln  Gln Thr Gly Ile Phe  Cys Ala Leu 
    1055                 1060                 1065             


Leu Asn  Leu Leu Glu Ser Ala  Glu Thr Glu Glu Val  Val Asp Ile 
    1070                 1075                 1080             


Phe Gln  Val Val Lys Ala Leu  Arg Lys Ala Arg Pro  Gly Met Val 
    1085                 1090                 1095             


Ser Thr  Phe Glu Gln Tyr Gln  Phe Leu Tyr Asp Val  Ile Ala Ser 
    1100                 1105                 1110             


Thr Tyr  Pro Ala Gln Asn Gly  Gln Val Lys Lys Asn  Asn His Gln 
    1115                 1120                 1125             


Glu Asp  Lys Ile Glu Phe Asp  Asn Glu Val Asp Lys  Val Lys Gln 
    1130                 1135                 1140             


Asp Ala  Asn Cys Val Asn Pro  Leu Gly Ala Pro Glu  Lys Leu Pro 
    1145                 1150                 1155             


Glu Ala  Lys Glu Gln Ala Glu  Gly Ser Glu Pro Thr  Ser Gly Thr 
    1160                 1165                 1170             


Glu Gly  Pro Glu His Ser Val  Asn Gly Pro Ala Ser  Pro Ala Leu 
    1175                 1180                 1185             


Asn Gln  Gly Ser 
    1190         


<210>  110
<211>  1258
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 


Ile Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
145                 150                 155                 160 


Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
                165                 170                 175     


Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
            180                 185                 190         


Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
        195                 200                 205             


Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
    210                 215                 220                 


Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
225                 230                 235                 240 


Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
                245                 250                 255     


Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
            260                 265                 270         


Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
        275                 280                 285             


Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
    290                 295                 300                 


Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
305                 310                 315                 320 


Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
                325                 330                 335     


Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
            340                 345                 350         


Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
        355                 360                 365             


Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
    370                 375                 380                 


Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
385                 390                 395                 400 


Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
                405                 410                 415     


Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
            420                 425                 430         


Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
        435                 440                 445             


Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
    450                 455                 460                 


Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
465                 470                 475                 480 


Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
                485                 490                 495     


Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
            500                 505                 510         


Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
        515                 520                 525             


Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
    530                 535                 540                 


Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
545                 550                 555                 560 


Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
                565                 570                 575     


Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
            580                 585                 590         


Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
        595                 600                 605             


Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
    610                 615                 620                 


Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
625                 630                 635                 640 


Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
                645                 650                 655     


Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
            660                 665                 670         


Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
        675                 680                 685             


Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
    690                 695                 700                 


Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
705                 710                 715                 720 


Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
                725                 730                 735     


Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
            740                 745                 750         


Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
        755                 760                 765             


Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
    770                 775                 780                 


Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
785                 790                 795                 800 


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
                805                 810                 815     


Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
            820                 825                 830         


Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
        835                 840                 845             


Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
    850                 855                 860                 


Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
865                 870                 875                 880 


Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
                885                 890                 895     


Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
            900                 905                 910         


His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
        915                 920                 925             


Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
    930                 935                 940                 


Met Ser Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp 
945                 950                 955                 960 


Ser Asp Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met 
                965                 970                 975     


Ser Tyr Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys 
            980                 985                 990         


Glu Thr Ile Gly Asp Phe Trp Gln  Met Ile Phe Gln Arg  Lys Val Lys 
        995                 1000                 1005             


Val Ile  Val Met Leu Thr Glu  Leu Lys His Gly Asp  Gln Glu Ile 
    1010                 1015                 1020             


Cys Ala  Gln Tyr Trp Gly Glu  Gly Lys Gln Thr Tyr  Gly Asp Ile 
    1025                 1030                 1035             


Glu Val  Asp Leu Lys Asp Thr  Asp Lys Ser Ser Thr  Tyr Thr Leu 
    1040                 1045                 1050             


Arg Val  Phe Glu Leu Arg His  Ser Lys Arg Lys Asp  Ser Arg Thr 
    1055                 1060                 1065             


Val Tyr  Gln Tyr Gln Tyr Thr  Asn Trp Ser Val Glu  Gln Leu Pro 
    1070                 1075                 1080             


Ala Glu  Pro Lys Glu Leu Ile  Ser Met Ile Gln Val  Val Lys Gln 
    1085                 1090                 1095             


Lys Leu  Pro Gln Lys Asn Ser  Ser Glu Gly Asn Lys  His His Lys 
    1100                 1105                 1110             


Ser Thr  Pro Leu Leu Ile His  Cys Arg Asp Gly Ser  Gln Gln Thr 
    1115                 1120                 1125             


Gly Ile  Phe Cys Ala Leu Leu  Asn Leu Leu Glu Ser  Ala Glu Thr 
    1130                 1135                 1140             


Glu Glu  Val Val Asp Ile Phe  Gln Val Val Lys Ala  Leu Arg Lys 
    1145                 1150                 1155             


Ala Arg  Pro Gly Met Val Ser  Thr Phe Glu Gln Tyr  Gln Phe Leu 
    1160                 1165                 1170             


Tyr Asp  Val Ile Ala Ser Thr  Tyr Pro Ala Gln Asn  Gly Gln Val 
    1175                 1180                 1185             


Lys Lys  Asn Asn His Gln Glu  Asp Lys Ile Glu Phe  Asp Asn Glu 
    1190                 1195                 1200             


Val Asp  Lys Val Lys Gln Asp  Ala Asn Cys Val Asn  Pro Leu Gly 
    1205                 1210                 1215             


Ala Pro  Glu Lys Leu Pro Glu  Ala Lys Glu Gln Ala  Glu Gly Ser 
    1220                 1225                 1230             


Glu Pro  Thr Ser Gly Thr Glu  Gly Pro Glu His Ser  Val Asn Gly 
    1235                 1240                 1245             


Pro Ala  Ser Pro Ala Leu Asn  Gln Gly Ser 
    1250                 1255             


<210>  111
<211>  1240
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His Ala Asp 
        35                  40                  45              


Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser Gly Ser 
    50                  55                  60                  


Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala Ile Ser 
65                  70                  75                  80  


Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr Asp Pro 
                85                  90                  95      


Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser Ser Ala 
            100                 105                 110         


Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn Thr Ser 
        115                 120                 125             


Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro Ser Gly 
    130                 135                 140                 


Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser Lys Pro 
145                 150                 155                 160 


Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu Tyr Asn 
                165                 170                 175     


Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu Asn Val 
            180                 185                 190         


Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn Leu Thr 
        195                 200                 205             


Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys Thr Ala 
    210                 215                 220                 


Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu Lys Phe 
225                 230                 235                 240 


Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr Ile Cys 
                245                 250                 255     


Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln Asn Ile 
            260                 265                 270         


Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys Glu Ile 
        275                 280                 285             


Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp Ser Glu 
    290                 295                 300                 


Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile Ile Lys 
305                 310                 315                 320 


Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys Arg Ser 
                325                 330                 335     


Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln Arg Ser 
            340                 345                 350         


Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys 
        355                 360                 365             


Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys 
    370                 375                 380                 


Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile Ala Lys 
385                 390                 395                 400 


Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr Lys Ser 
                405                 410                 415     


Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr Ser Asp 
            420                 425                 430         


Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro 
        435                 440                 445             


His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu Val Arg 
    450                 455                 460                 


Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu Gln Tyr 
465                 470                 475                 480 


Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp Tyr Pro 
                485                 490                 495     


Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser Lys Ala 
            500                 505                 510         


Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile Ala Leu 
        515                 520                 525             


Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg Ser Cys 
    530                 535                 540                 


Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu Lys Gln 
545                 550                 555                 560 


Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu Thr Tyr 
                565                 570                 575     


Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu Phe Gln 
            580                 585                 590         


Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala Arg Lys 
        595                 600                 605             


Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro Tyr Asp 
    610                 615                 620                 


Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly Ser Asn 
625                 630                 635                 640 


Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg Lys Tyr 
                645                 650                 655     


Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe Trp Arg 
            660                 665                 670         


Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr Arg Cys 
        675                 680                 685             


Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser Met Glu 
    690                 695                 700                 


Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn Gln His 
705                 710                 715                 720 


Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val Asn Lys 
                725                 730                 735     


Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe Thr Ser 
            740                 745                 750         


Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu Lys Leu 
        755                 760                 765             


Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro Ile Val 
    770                 775                 780                 


Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile Gly Ile 
785                 790                 795                 800 


Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp Val Tyr 
                805                 810                 815     


Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val Gln Val 
            820                 825                 830         


Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr Asn Gln 
        835                 840                 845             


Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr Leu His 
    850                 855                 860                 


Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu Glu Ala 
865                 870                 875                 880 


Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln His Ile 
                885                 890                 895     


Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn Val Ile 
            900                 905                 910         


Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu Met Ser 
        915                 920                 925             


Lys Glu Ser Glu His Asp Ser Asp Glu Ser Ser Asp Asp Asp Ser Asp 
    930                 935                 940                 


Ser Glu Glu Pro Ser Lys Tyr Ile Asn Ala Ser Phe Ile Met Ser Tyr 
945                 950                 955                 960 


Trp Lys Pro Glu Val Met Ile Ala Ala Gln Gly Pro Leu Lys Glu Thr 
                965                 970                 975     


Ile Gly Asp Phe Trp Gln Met Ile Phe Gln Arg Lys Val Lys Val Ile 
            980                 985                 990         


Val Met Leu Thr Glu Leu Lys His  Gly Asp Gln Glu Ile  Cys Ala Gln 
        995                 1000                 1005             


Tyr Trp  Gly Glu Gly Lys Gln  Thr Tyr Gly Asp Ile  Glu Val Asp 
    1010                 1015                 1020             


Leu Lys  Asp Thr Asp Lys Ser  Ser Thr Tyr Thr Leu  Arg Val Phe 
    1025                 1030                 1035             


Glu Leu  Arg His Ser Lys Arg  Lys Asp Ser Arg Thr  Val Tyr Gln 
    1040                 1045                 1050             


Tyr Gln  Tyr Thr Asn Trp Ser  Val Glu Gln Leu Pro  Ala Glu Pro 
    1055                 1060                 1065             


Lys Glu  Leu Ile Ser Met Ile  Gln Val Val Lys Gln  Lys Leu Pro 
    1070                 1075                 1080             


Gln Lys  Asn Ser Ser Glu Gly  Asn Lys His His Lys  Ser Thr Pro 
    1085                 1090                 1095             


Leu Leu  Ile His Cys Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe 
    1100                 1105                 1110             


Cys Ala  Leu Leu Asn Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val 
    1115                 1120                 1125             


Val Asp  Ile Phe Gln Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro 
    1130                 1135                 1140             


Gly Met  Val Ser Thr Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Val 
    1145                 1150                 1155             


Ile Ala  Ser Thr Tyr Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn 
    1160                 1165                 1170             


Asn His  Gln Glu Asp Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys 
    1175                 1180                 1185             


Val Lys  Gln Asp Ala Asn Cys  Val Asn Pro Leu Gly  Ala Pro Glu 
    1190                 1195                 1200             


Lys Leu  Pro Glu Ala Lys Glu  Gln Ala Glu Gly Ser  Glu Pro Thr 
    1205                 1210                 1215             


Ser Gly  Thr Glu Gly Pro Glu  His Ser Val Asn Gly  Pro Ala Ser 
    1220                 1225                 1230             


Pro Ala  Leu Asn Gln Gly Ser  
    1235                 1240 


<210>  112
<211>  1306
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Thr Met Tyr Leu Trp Leu Lys Leu Leu Ala Phe Gly Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Ser Pro Thr Pro Ser Pro 
            20                  25                  30          


Thr Gly Leu Thr Thr Ala Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Thr Phe Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Thr Ser Leu Ser Pro Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Val Gln Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Ala Gly Thr Asp Thr Gln Thr Phe Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Ala Lys Leu Asn Pro Thr Pro Gly Ser Asn Ala 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Val Ser Pro Leu Thr Thr Thr Leu Ser Leu Ala His His Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Asp Ala Tyr Leu Asn Ala Ser Glu Thr Thr Thr Leu Ser Pro 
        195                 200                 205             


Ser Gly Ser Ala Val Ile Ser Thr Thr Thr Ile Ala Thr Thr Pro Ser 
    210                 215                 220                 


Lys Pro Thr Cys Asp Glu Lys Tyr Ala Asn Ile Thr Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Lys Glu Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Gly Asn Asn Thr Cys Thr Asn Asn Glu Val His Asn 
            260                 265                 270         


Leu Thr Glu Cys Lys Asn Ala Ser Val Ser Ile Ser His Asn Ser Cys 
        275                 280                 285             


Thr Ala Pro Asp Lys Thr Leu Ile Leu Asp Val Pro Pro Gly Val Glu 
    290                 295                 300                 


Lys Phe Gln Leu His Asp Cys Thr Gln Val Glu Lys Ala Asp Thr Thr 
305                 310                 315                 320 


Ile Cys Leu Lys Trp Lys Asn Ile Glu Thr Phe Thr Cys Asp Thr Gln 
                325                 330                 335     


Asn Ile Thr Tyr Arg Phe Gln Cys Gly Asn Met Ile Phe Asp Asn Lys 
            340                 345                 350         


Glu Ile Lys Leu Glu Asn Leu Glu Pro Glu His Glu Tyr Lys Cys Asp 
        355                 360                 365             


Ser Glu Ile Leu Tyr Asn Asn His Lys Phe Thr Asn Ala Ser Lys Ile 
    370                 375                 380                 


Ile Lys Thr Asp Phe Gly Ser Pro Gly Glu Pro Gln Ile Ile Phe Cys 
385                 390                 395                 400 


Arg Ser Glu Ala Ala His Gln Gly Val Ile Thr Trp Asn Pro Pro Gln 
                405                 410                 415     


Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Ile Lys Glu Thr Glu Lys 
            420                 425                 430         


Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp Leu Gln Asn 
        435                 440                 445             


Leu Lys Pro Tyr Thr Lys Tyr Val Leu Ser Leu His Ala Tyr Ile Ile 
    450                 455                 460                 


Ala Lys Val Gln Arg Asn Gly Ser Ala Ala Met Cys His Phe Thr Thr 
465                 470                 475                 480 


Lys Ser Ala Pro Pro Ser Gln Val Trp Asn Met Thr Val Ser Met Thr 
                485                 490                 495     


Ser Asp Asn Ser Met His Val Lys Cys Arg Pro Pro Arg Asp Arg Asn 
            500                 505                 510         


Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn Thr Leu 
        515                 520                 525             


Val Arg Asn Glu Ser His Lys Asn Cys Asp Phe Arg Val Lys Asp Leu 
    530                 535                 540                 


Gln Tyr Ser Thr Asp Tyr Thr Phe Lys Ala Tyr Phe His Asn Gly Asp 
545                 550                 555                 560 


Tyr Pro Gly Glu Pro Phe Ile Leu His His Ser Thr Ser Tyr Asn Ser 
                565                 570                 575     


Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile Val Thr Ser Ile 
            580                 585                 590         


Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu His Lys Lys Arg 
        595                 600                 605             


Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu Arg Asp Asp Glu 
    610                 615                 620                 


Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp Ile Leu Leu Glu 
625                 630                 635                 640 


Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu Phe Leu Ala Glu 
                645                 650                 655     


Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro Ile Lys Glu Ala 
            660                 665                 670         


Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val Asp Ile Leu Pro 
        675                 680                 685             


Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn Gly Asp Ala Gly 
    690                 695                 700                 


Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe Lys Glu Pro Arg 
705                 710                 715                 720 


Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr Val Asp Asp Phe 
                725                 730                 735     


Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile Val Met Val Thr 
            740                 745                 750         


Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu Tyr Trp Pro Ser 
        755                 760                 765             


Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val Val Lys Ile Asn 
    770                 775                 780                 


Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys Leu Asn Ile Val 
785                 790                 795                 800 


Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr His Ile Gln Phe 
                805                 810                 815     


Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro His Leu Leu Leu 
            820                 825                 830         


Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe Phe Ser Gly Pro 
        835                 840                 845             


Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile 
    850                 855                 860                 


Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu Asn Lys Val Asp 
865                 870                 875                 880 


Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg Cys Leu Met Val 
                885                 890                 895     


Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala Leu Val Glu Tyr 
            900                 905                 910         


Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu Leu His Pro Tyr 
        915                 920                 925             


Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu Pro Ser Pro Leu 
    930                 935                 940                 


Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser Trp Arg Thr Gln 
945                 950                 955                 960 


His Ile Gly Asn Gln Glu Glu Asn Lys Ser Lys Asn Arg Asn Ser Asn 
                965                 970                 975     


Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys His Glu Leu Glu 
            980                 985                 990         


Met Ser Lys Glu Ser Glu His Asp  Ser Asp Glu Ser Ser  Asp Asp Asp 
        995                 1000                 1005             


Ser Asp  Ser Glu Glu Pro Ser  Lys Tyr Ile Asn Ala  Ser Phe Ile 
    1010                 1015                 1020             


Met Ser  Tyr Trp Lys Pro Glu  Val Met Ile Ala Ala  Gln Gly Pro 
    1025                 1030                 1035             


Leu Lys  Glu Thr Ile Gly Asp  Phe Trp Gln Met Ile  Phe Gln Arg 
    1040                 1045                 1050             


Lys Val  Lys Val Ile Val Met  Leu Thr Glu Leu Lys  His Gly Asp 
    1055                 1060                 1065             


Gln Glu  Ile Cys Ala Gln Tyr  Trp Gly Glu Gly Lys  Gln Thr Tyr 
    1070                 1075                 1080             


Gly Asp  Ile Glu Val Asp Leu  Lys Asp Thr Asp Lys  Ser Ser Thr 
    1085                 1090                 1095             


Tyr Thr  Leu Arg Val Phe Glu  Leu Arg His Ser Lys  Arg Lys Asp 
    1100                 1105                 1110             


Ser Arg  Thr Val Tyr Gln Tyr  Gln Tyr Thr Asn Trp  Ser Val Glu 
    1115                 1120                 1125             


Gln Leu  Pro Ala Glu Pro Lys  Glu Leu Ile Ser Met  Ile Gln Val 
    1130                 1135                 1140             


Val Lys  Gln Lys Leu Pro Gln  Lys Asn Ser Ser Glu  Gly Asn Lys 
    1145                 1150                 1155             


His His  Lys Ser Thr Pro Leu  Leu Ile His Cys Arg  Asp Gly Ser 
    1160                 1165                 1170             


Gln Gln  Thr Gly Ile Phe Cys  Ala Leu Leu Asn Leu  Leu Glu Ser 
    1175                 1180                 1185             


Ala Glu  Thr Glu Glu Val Val  Asp Ile Phe Gln Val  Val Lys Ala 
    1190                 1195                 1200             


Leu Arg  Lys Ala Arg Pro Gly  Met Val Ser Thr Phe  Glu Gln Tyr 
    1205                 1210                 1215             


Gln Phe  Leu Tyr Asp Val Ile  Ala Ser Thr Tyr Pro  Ala Gln Asn 
    1220                 1225                 1230             


Gly Gln  Val Lys Lys Asn Asn  His Gln Glu Asp Lys  Ile Glu Phe 
    1235                 1240                 1245             


Asp Asn  Glu Val Asp Lys Val  Lys Gln Asp Ala Asn  Cys Val Asn 
    1250                 1255                 1260             


Pro Leu  Gly Ala Pro Glu Lys  Leu Pro Glu Ala Lys  Glu Gln Ala 
    1265                 1270                 1275             


Glu Gly  Ser Glu Pro Thr Ser  Gly Thr Glu Gly Pro  Glu His Ser 
    1280                 1285                 1290             


Val Asn  Gly Pro Ala Ser Pro  Ala Leu Asn Gln Gly  Ser 
    1295                 1300                 1305     


<210>  113
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  113

Gln Ser Pro Thr Pro Ser Pro Thr Gly Leu Thr Thr Ala Lys Met Pro 
1               5                   10                  15      


Ser Val Pro Leu Ser Ser Asp Pro Leu Pro Thr His Thr Thr Ala Phe 
            20                  25                  30          


Ser Pro Ala Ser Thr Phe Glu Arg Glu Asn Asp Phe Ser Glu Thr Thr 
        35                  40                  45              


Thr Ser Leu Ser Pro Asp Asn Thr Ser Thr Gln Val Ser Pro Asp Ser 
    50                  55                  60                  


Leu Asp Asn Ala Ser Ala Phe Asn Thr Thr Gly Val Ser Ser Val Gln 
65                  70                  75                  80  


Thr Pro His Leu Pro Thr His Ala Asp Ser Gln Thr Pro Ser Ala Gly 
                85                  90                  95      


Thr Asp Thr Gln Thr Phe Ser Gly Ser Ala Ala Asn Ala Lys Leu Asn 
            100                 105                 110         


Pro Thr Pro Gly Ser Asn Ala Ile Ser Asp Val Pro Gly Glu Arg Ser 
        115                 120                 125             


Thr Ala Ser Thr Phe Pro Thr Asp Pro Val Ser Pro Leu Thr Thr Thr 
    130                 135                 140                 


Leu Ser Leu Ala His His Ser Ser Ala Ala Leu Pro Ala Arg Thr Ser 
145                 150                 155                 160 


Asn Thr Thr Ile Thr Ala Asn Thr Ser Asp Ala Tyr Leu Asn Ala Ser 
                165                 170                 175     


Glu Thr Thr Thr Leu Ser Pro Ser Gly Ser Ala Val Ile Ser Thr Thr 
            180                 185                 190         


Thr Ile Ala Thr Thr Pro Ser Lys Pro Thr Cys Asp Glu Lys Tyr Ala 
        195                 200                 205             


Asn Ile Thr Val Asp Tyr Leu Tyr Asn Lys Glu Thr Lys Leu Phe Thr 
    210                 215                 220                 


Ala Lys Leu Asn Val Asn Glu Asn Val Glu Cys Gly Asn Asn Thr Cys 
225                 230                 235                 240 


Thr Asn Asn Glu Val His Asn Leu Thr Glu Cys Lys Asn Ala Ser Val 
                245                 250                 255     


Ser Ile Ser His Asn Ser Cys Thr Ala Pro Asp Lys Thr Leu Ile Leu 
            260                 265                 270         


Asp Val Pro Pro Gly Val Glu Lys Phe Gln Leu His Asp Cys Thr Gln 
        275                 280                 285             


Val Glu Lys Ala Asp Thr Thr Ile Cys Leu Lys Trp Lys Asn Ile Glu 
    290                 295                 300                 


Thr Phe Thr Cys Asp Thr Gln Asn Ile Thr Tyr Arg Phe Gln Cys Gly 
305                 310                 315                 320 


Asn Met Ile Phe Asp Asn Lys Glu Ile Lys Leu Glu Asn Leu Glu Pro 
                325                 330                 335     


Glu His Glu Tyr Lys Cys Asp Ser Glu Ile Leu Tyr Asn Asn His Lys 
            340                 345                 350         


Phe Thr Asn Ala Ser Lys Ile Ile Lys Thr Asp Phe Gly Ser Pro Gly 
        355                 360                 365             


Glu Pro Gln Ile Ile Phe Cys Arg Ser Glu Ala Ala His Gln Gly Val 
    370                 375                 380                 


Ile Thr Trp Asn Pro Pro Gln Arg Ser Phe His Asn Phe Thr Leu Cys 
385                 390                 395                 400 


Tyr Ile Lys Glu Thr Glu Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu 
                405                 410                 415     


Ile Lys Tyr Asp Leu Gln Asn Leu Lys Pro Tyr Thr Lys Tyr Val Leu 
            420                 425                 430         


Ser Leu His Ala Tyr Ile Ile Ala Lys Val Gln Arg Asn Gly Ser Ala 
        435                 440                 445             


Ala Met Cys His Phe Thr Thr Lys Ser Ala Pro Pro Ser Gln Val Trp 
    450                 455                 460                 


Asn Met Thr Val Ser Met Thr Ser Asp Asn Ser Met His Val Lys Cys 
465                 470                 475                 480 


Arg Pro Pro Arg Asp Arg Asn Gly Pro His Glu Arg Tyr His Leu Glu 
                485                 490                 495     


Val Glu Ala Gly Asn Thr Leu Val Arg Asn Glu Ser His Lys Asn Cys 
            500                 505                 510         


Asp Phe Arg Val Lys Asp Leu Gln Tyr Ser Thr Asp Tyr Thr Phe Lys 
        515                 520                 525             


Ala Tyr Phe His Asn Gly Asp Tyr Pro Gly Glu Pro Phe Ile Leu His 
    530                 535                 540                 


His Ser Thr Ser Tyr Asn Ser Lys 
545                 550         


<210>  114
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  114

Thr Glu Lys Asp Cys Leu Asn Leu Asp Lys Asn Leu Ile Lys Tyr Asp 
1               5                   10                  15      


Leu Gln Asn Leu Lys 
            20      


<210>  115
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  115

Cys Tyr Ile Lys Glu Thr Glu Lys Asp Cys Leu Asn Leu Asp Lys Asn 
1               5                   10                  15      


Leu Ile Lys Tyr Asp Leu Gln Asn Leu Lys Pro Tyr Thr Lys Tyr 
            20                  25                  30      


<210>  116
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  116

Arg Pro Pro Arg Asp Arg Asn Gly Pro His Glu Arg Tyr His Leu Glu 
1               5                   10                  15      


Val Glu Ala Gly Asn Thr Leu Val Arg Asn Glu Ser His 
            20                  25                  


<210>  117
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  117

Cys Arg Pro Pro Arg Asp Arg Asn Gly Pro His Glu Arg Tyr His Leu 
1               5                   10                  15      


Glu Val Glu Ala Gly Asn Thr Leu Val Arg Asn Glu Ser His Lys 
            20                  25                  30      


<210>  118
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  118

Arg Asn Gly Pro His Glu Arg Tyr His Leu Glu Val Glu Ala Gly Asn 
1               5                   10                  15      


Thr 
    


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  S, E or G

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  S, A or G

<400>  119

Phe Thr Phe Xaa Xaa Tyr Ser Met Asn 
1               5                   


<210>  120
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  S, L or I

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  S or G

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  S or A

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Y, H or T

<400>  120

Tyr Ile Ser Xaa Ser Xaa Xaa Thr Ile Xaa Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  121
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D or T

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  R or D

<400>  121

Ala Arg Gly Gly Gln Tyr Tyr Tyr Xaa Ser Ser Xaa Tyr Gly Glu Val 
1               5                   10                  15      


Ala Phe Asp Ile 
            20  


<210>  122
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  H or absent

<400>  122

Arg Ser Ser Gln Ser Leu Leu Xaa Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  L or F

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  N or S

<400>  123

Xaa Gly Ser Xaa Arg Ala Ser 
1               5           


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic peptide


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  P or W

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  F or S

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  T or F

<400>  124

Met Gln Arg Arg Arg Thr Pro Xaa Xaa Xaa 
1               5                   10  


<210>  125
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  125
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtagtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agctgaggac acggcggtgt actactgcgc cagaggtgga      300

caatactact acgacagcag cagatacggt gaggtagcat tcgacatatg gggtcagggt      360

acaatggtca ccgtctcctc a                                                381


<210>  126
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  126
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcagagaag acgcactcct      300

cctttcactt ttggcggagg gaccaaggtt gagatcaaa                             339


<210>  127
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  127
gaagtgcagc ttgtggagtc cggtggcgga ctggtccagc cgggcggatc tctgagactt       60

tcgtgtgccg cctcgggatt caccttcgaa gcgtattcca tgaactgggt cagacaggcc      120

cccggaaagg gcctggaatg ggtgtcgtac attagcctgt cgggggccac catccattac      180

gccgatagcg tgaagggccg gttcacaatc tcccgggaca acgccaagaa ctccctctac      240

ctccaaatga acagcctgcg cgctgaggac actgctgtgt actattgcgc gaggggtggc      300

cagtactact acgactcaag cgactacggc gaagtggcat tcgatatctg gggacagggg      360

accatggtca ccgtcagctc c                                                381


<210>  128
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  128
gatatcgtga tgacacagtc ccctctgtcc ctccctgtga cccccggaga accagcctct       60

atttcctgcc ggtcctccca atccctggtg tccaacggtt ataactacct ggattggtac      120

ttgcaaaagc ccggacagag cccccagctg ctcatctact tcggaagctc acgcgcgagc      180

ggggtgccgg ataggttttc gggatccgga agcggcaccg acttcacgct gaagatctcg      240

agagtcgagg ccgaggacgt gggcgtgtac tactgtatgc agcggcggcg caccccctgg      300

tccttcggcg gcggaactaa ggtcgagatc aag                                   333


<210>  129
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  129
caagtgcagc ttgtggagtc cggtggcgga ctggtcaagc cgggcggatc tctgagactt       60

tcgtgtgccg cctcgggatt caccttcggc ggatattcca tgaactgggt cagacaggcc      120

cccggaaagg gcctggaatg ggtgtcgtac attagcatct cgggggccac catcacttac      180

gccgatagcg tgaagggccg gttcacaatc tcccgggaca acgccaagaa ctccctctac      240

ctccaaatga acagcctgcg cgctgaggac actgctgtgt actattgcgc gaggggtggc      300

cagtactact acgactcaag cgactacggc gaagtggcat tcgatatctg gggacagggg      360

accatggtca ccgtcagctc c                                                381


<210>  130
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  130
gatatcgtga tgacacagtc ccctctgtcc ctccctgtga cccccggaga accagcctct       60

atttcctgcc ggtcctccca atccctggtg tccaacggtt ataactacct ggattggtac      120

ttgcaaaagc ccggacagag cccccagctg ctcatctact tcggaagctc acgcgcgagc      180

ggggtgccgg ataggttttc gggatccgga agcggcaccg acttcacgct gaagatctcg      240

agagtcgagg ccgaggacgt gggcgtgtac tactgtatgc agcggcggcg caccccgccc      300

ttcaccttcg gcggcggaac taaggtcgag atcaag                                336


<210>  131
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  131
gaagtgcagc ttgtggagtc cggtggcgga ctggtccagc cgggcggatc tctgagactt       60

tcgtgtgccg cctcgggatt caccttcgaa gcgtattcca tgaactgggt cagacaggcc      120

cccggaaagg gcctggaatg ggtgtcgtac attagcctgt cgggggccac catccattac      180

gccgatagcg tgaagggccg gttcacaatc tcccgggaca acgccaagaa ctccctctac      240

ctccaaatga acagcctgcg cgctgaggac actgctgtgt actattgcgc gaggggtggc      300

cagtactact acacctcaag cgactacggc gaagtggcat tcgatatctg gggacagggg      360

accatggtca ccgtcagctc c                                                381


<210>  132
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  132
gatatcgtga tgacacagtc ccctctgtcc ctccctgtga cccccggaga accagcctct       60

atttcctgcc ggtcctccca atccctggtg tccaacggtt ataactacct ggattggtac      120

ttgcaaaagc ccggacagag cccccagctg ctcatctact tcggaagctc acgcgcgagc      180

ggggtgccgg ataggttttc gggatccgga agcggcaccg acttcacgct gaagatctcg      240

agagtcgagg ccgaggacgt gggcgtgtac tactgtatgc agcggcggcg caccccctgg      300

tccttcggcg gcggaactaa ggtcgagatc aag                                   333


<210>  133
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  133
gaagtgcagc ttgtggagtc cggtggcgga ctggtccagc cgggcggatc tctgagactt       60

tcgtgtgccg cctcgggatt caccttcgaa gcgtattcca tgaactgggt cagacaggcc      120

cccggaaagg gcctggaatg ggtgtcgtac attagcctgt cgggggccac catccattac      180

gccgatagcg tgaagggccg gttcacaatc tcccgggaca acgccaagaa ctccctctac      240

ctccaaatga acagcctgcg cgctgaggac actgctgtgt actattgcgc gaggggtggc      300

cagtactact acacctcaag cgactacggc gaagtggcat tcgatatctg gggacagggg      360

accatggtca ccgtcagctc c                                                381


<210>  134
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  134
gatatcgtga tgacacagtc ccctctgtcc ctccctgtga cccccggaga accagcctct       60

atttcctgcc ggtcctccca atccctggtg tcctcgggtt ataactacct ggattggtac      120

ttgcaaaagc ccggacagag cccccagctg ctcatctact tcggaagctc acgcgcgagc      180

ggggtgccgg ataggttttc gggatccgga agcggcaccg acttcacgct gaagatctcg      240

agagtcgagg ccgaggacgt gggcgtgtac tactgtatgc agcggcggcg caccccctgg      300

tccttcggcg gcggaactaa ggtcgagatc aag                                   333


<210>  135
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  135
gaggtgcagc tggtcgaaag cggaggaggg ctggtgcagc ctggaggatc cctgcggctc       60

tcatgtgccg cctccggctt taccttcgaa gcctactcca tgaactgggt cagacaggct      120

cccgggaagg gactggaatg ggtcagctac atttcgctgt ccggagccac catccactac      180

gctgactcag ttaagggacg cttcaccatc tcccgggata atgcaaagaa ctccctgtac      240

ctccaaatga attcactgag ggccgaggac actgccgtgt actactgcgc ccggggaggt      300

caatactatt acacctcctc cgactacggc gaagtggcct tcgatatctg gggccaagga      360

accctcgtga ctgtctcctc c                                                381


<210>  136
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  136
gacatcgtgc tgacccagtc accgctttcc ttgcccgtga ctcctgggga accggcctcc       60

atttcgtgcc ggtccagcca gtccctggtg tcctccggct acaattacct ggattggtac      120

ctccaaaagc ccggacagtc cccacaactg ctcatctact tcgggagctc aagggcctca      180

ggagtgccgg atcgcttctc gggttccgga agcgggactg acttcactct gaaaatcagc      240

cgcgtggaag cagaggacgt gggcgtgtac tactgcatgc agcgcaggag aaccccctgg      300

tcctttggcg gtggaacgaa ggtcgaaatc aag                                   333


<210>  137
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  137
caagtgcagc ttgtggagtc cggtggcgga ctggtcaagc cgggcggatc tctgagactt       60

tcgtgtgccg cctcgggatt caccttcggc ggatattcca tgaactgggt cagacaggcc      120

cccggaaagg gcctggaatg ggtgtcgtac attagcatct cgggggccac catcacttac      180

gccgatagcg tgaagggccg gttcacaatc tcccgggaca acgccaagaa ctccctctac      240

ctccaaatga acagcctgcg cgctgaggac actgctgtgt actattgcgc gaggggtggc      300

cagtactact acgactcaag cgactacggc gaagtggcat tcgatatctg gggacagggg      360

accatggtca ccgtcagctc c                                                381


<210>  138
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  138
gatatcgtga tgacacagtc ccctctgtcc ctccctgtga cccccggaga accagcctct       60

atttcctgcc ggtcctccca atccctggtg tcctccggtt ataactacct ggattggtac      120

ttgcaaaagc ccggacagag cccccagctg ctcatctact tcggaagctc acgcgcgagc      180

ggggtgccgg ataggttttc gggatccgga agcggcaccg acttcacgct gaagatctcg      240

agagtcgagg ccgaggacgt gggcgtgtac tactgtatgc agcggcggcg caccccgccc      300

ttcaccttcg gcggcggaac taaggtcgag atcaag                                336


<210>  139
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  139
gaagtgcagc ttctggagtc cggtggcgga ctggtccagc cgggcggatc tctgagactt       60

tcgtgtgccg cctcgggatt caccttcaac aactattgga tgacctgggt cagacaggcc      120

cccggaaagg gcctggaatg ggtgtcgtca attagctcct cggggggatc catctactac      180

cctgatcgcg tgaagggccg gttcacaatc tcccgggaca acagcaagaa caccctctac      240

ctccaaatga acagcctgcg cgctgaggac actgctgtgt actattgcgc gagggacgag      300

agatgggccg gcgcaatgga tgcctgggga caggggacca ccgtcaccgt cagctcc         357


<210>  140
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  140
gatattcaga tgacccagtc cccatcatcc ctgtccgcct ccgtgggcga ccgcgtgacg       60

atcacttgca aagccagcca gaatatcaac aagaacctgg attggtacca acagaagccg      120

gggaaggccc ctaagctgct gatctacgaa accaacaact tgcaaactgg cgtgccgtca      180

aggttcagcg gttccgggtc gggcaccgac ttcaccctga ccatttcctc gctgcaaccc      240

gaggacttcg cgacctacta ctgctatcag cacaacagcc ggttcacctt cggacagggc      300

accaagctcg agatcaag                                                    318


<210>  141
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  141
gaagtgcagc tcgtggagtc gggtggaggc cttgtgcaac cgggaggatc cctgcggctc       60

tcctgcgccg catcaggctt cacgttcacc aacttttgga tggcctggat tagacaggca      120

ccggggaagg gactggaatg ggtggcgtcc attagctcgt ccggaggatc catctactat      180

cctgactcag tgaaggacag gtttaccatc tcccgggaca acagcaagaa cactctgtac      240

ctccaaatga actcgctgcg cgccgaggac accgccgtgt actactgcgt gaagttccat      300

cactactccg gcggaggaga tgcctgggga cagggtactc tcgtgactgt gtcgtcc         357


<210>  142
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  142
gacatccaga tgacccagag cccctcctcc ctgtccgcgt ctgtgggcga ccgcgtgacc       60

attacgtgca aagcttccca gaacattaac aagtacctgg attggtacca gcagaagcct      120

ggaaaggccc ccaagctgtt gatccactac acaaacaacc tccacactgg tatcccgtcc      180

cggttctcgg ggtccggatc gggaactgac tacaccctga ccatcagcag cctgcagcct      240

gaagatttcg ccacctatta ctgcctgcaa cactcctcgc gctggacctt cggcgggggt      300

actaaggtcg agatcaag                                                    318


<210>  143
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  143
gaagtgcagc tcgtggagtc gggtggaggc cttgtgcaac cgggaggatc cctgcggctc       60

tcctgcgccg catcaggctt cacgttcaac aactactgga tgacttgggt cagacaggca      120

ccggggaagg gactggaatg ggtgtccagc attagctcgt ccggaggatc catctactat      180

ccggactcag tgaaggacag gtttaccatc tcccgggaca acgcaaagaa ctccctgtac      240

ctccaaatga actcgctgcg cgccgaggac atggccgtgt actactgcgc gaggctgtac      300

tactacgatg gggggggcga tgcctgggga cagggaaccc tagtgactgt gtcgtcc         357


<210>  144
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  144
ggaatccaga tgacacagag cccgtctagc ctgtcagcat ccgtggggga cagggtcacc       60

atcacctgta aagccagcca ggatattaac aagtacctgg actggtacca gcagaagccc      120

gggaaggccc cgaagctcct gatctacaac accaacaact tgcacaccgg aattccgtcc      180

cgcttttcgg gatcgggatc cgggaccgat tacaccctga ctatctcctc cctgcaaccc      240

gaggacttcg ccacttacta ttgcctccaa cacatttccc ggtggacttt cggcggcggc      300

accaaggtcg agatcaag                                                    318


<210>  145
<211>  1310
<212>  PRT
<213>  Macaca fascicularis

<400>  145

Met Thr Met Cys Leu Trp Leu Lys Leu Leu Ala Phe Val Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Gly Ser Thr Leu Ser Pro 
            20                  25                  30          


Thr Gly Arg Arg Thr Thr Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Ile Ser Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Pro Ser Leu Ser Ser Asp Asn 
65                  70                  75                  80  


Thr Ser Thr Gln Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Ala Leu Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Thr Gly Thr Asp Thr Gln Thr Pro Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Thr Thr Leu Ser Pro Thr Pro Arg Ser Asn Asp 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Ile Ser Pro Leu Ala Thr Thr Leu Ile Pro Ala Arg Asn Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Val Ser Tyr Leu Asn Ala Ser Glu Thr Thr Thr Pro Ser Pro 
        195                 200                 205             


Ser Gly Ser Thr Val Ile Ser Thr Pro Thr Ile Ala Thr Thr Thr Ser 
    210                 215                 220                 


Lys Pro Thr Cys Ala Glu Lys Tyr Ala Thr Ile Pro Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Asn Lys Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Thr Asn Asn Asn His Thr His Asn Ile Cys Thr Asn 
            260                 265                 270         


Asn Glu Val Leu Asn Leu Pro Glu Cys Lys Glu Met Asn Val Phe Val 
        275                 280                 285             


Ser His Asn Ser Cys Thr Asp Arg His Lys Glu Leu Lys Leu Asp Val 
    290                 295                 300                 


Pro Pro Glu Val Glu Lys Phe Gln Leu Asp Asp Cys Thr Pro Asp Val 
305                 310                 315                 320 


Glu Ala Asn Thr Thr Ile Cys Leu Lys Trp Lys Ile Ile Glu Thr Phe 
                325                 330                 335     


Ala Cys Asp Lys Ser Lys Ile Thr Tyr Arg Phe Gln Cys Gly Asn Lys 
            340                 345                 350         


Thr Tyr Asn Lys Glu Gly Ile Tyr Leu Glu Asn Leu Glu Pro Glu Tyr 
        355                 360                 365             


Glu Tyr Lys Cys Asp Ser Glu Ile Leu Tyr Asn Asn His Lys Tyr Ile 
    370                 375                 380                 


Asn Ile Thr Lys Leu Ile Lys Thr Asp Phe Gly Ile Pro Gly Gln Pro 
385                 390                 395                 400 


Gln Asn Val Val Cys Arg His Glu Asp Ala His Gln Gly Val Ile Thr 
                405                 410                 415     


Trp Asn Pro Pro Gln Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Val 
            420                 425                 430         


Asn Lys Pro Ala Lys Lys Cys Leu Ile Leu Asp Lys His Leu Thr Thr 
        435                 440                 445             


Tyr His Leu Gln Asn Leu Lys Pro Tyr Thr Asn Tyr Ser Leu Ser Leu 
    450                 455                 460                 


His Ala Tyr Ile Ile Ala Lys Val Gln Arg Asn Gly Thr Ala Ala Thr 
465                 470                 475                 480 


Cys Asn Phe Thr Thr Glu Ser Ala Pro Pro Ser Gln Val Gln Asn Met 
                485                 490                 495     


Ile Val Ser Thr Ser Asp Asn Ser Met His Val Lys Cys Glu Val Pro 
            500                 505                 510         


Arg Asp Val Asn Gly Pro Thr Gly Leu Tyr His Leu Glu Val Glu Ala 
        515                 520                 525             


Gly Asn Thr Leu Val Arg Asn Leu Ser Gln Ser Lys Cys Asp Phe Ser 
    530                 535                 540                 


Val Asn Asn Leu Gln Tyr Ser Thr Tyr Tyr Asn Leu Lys Ala Tyr Tyr 
545                 550                 555                 560 


His Asn Gly Lys Tyr Ser Gly Glu Pro Val Ile Leu Arg Glu Ser Thr 
                565                 570                 575     


Ser Tyr Asn Ser Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile 
            580                 585                 590         


Val Thr Ser Ile Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu 
        595                 600                 605             


His Lys Lys Arg Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu 
    610                 615                 620                 


Arg Asp Asp Glu Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp 
625                 630                 635                 640 


Ile Leu Leu Glu Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu 
                645                 650                 655     


Phe Leu Ala Glu Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro 
            660                 665                 670         


Ile Lys Glu Ala Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val 
        675                 680                 685             


Asp Ile Leu Pro Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn 
    690                 695                 700                 


Gly Asp Ala Gly Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe 
705                 710                 715                 720 


Lys Glu Pro Arg Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr 
                725                 730                 735     


Val Asp Asp Phe Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile 
            740                 745                 750         


Val Met Val Thr Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu 
        755                 760                 765             


Tyr Trp Pro Ser Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Ile Val 
    770                 775                 780                 


Val Lys Ile Asn Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys 
785                 790                 795                 800 


Leu Asn Ile Val Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr 
                805                 810                 815     


His Ile Gln Phe Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro 
            820                 825                 830         


His Leu Leu Leu Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe 
        835                 840                 845             


Phe Ser Gly Pro Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr 
    850                 855                 860                 


Gly Thr Tyr Ile Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu 
865                 870                 875                 880 


Asn Lys Val Asp Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg 
                885                 890                 895     


Cys Leu Met Val Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala 
            900                 905                 910         


Leu Val Glu Tyr Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu 
        915                 920                 925             


Leu His Pro Tyr Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu 
    930                 935                 940                 


Pro Ser Pro Leu Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser 
945                 950                 955                 960 


Trp Arg Thr Gln His Ile Gly Asn Gln Glu Glu Asn Lys Asn Lys Asn 
                965                 970                 975     


Arg Asn Ser Asn Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys 
            980                 985                 990         


His Glu Leu Glu Met Ser Lys Glu  Ser Asp His Asp Ser  Asp Glu Ser 
        995                 1000                 1005             


Ser Asp  Asp Asp Ser Asp Ser  Glu Glu Pro Ser Lys  Tyr Ile Asn 
    1010                 1015                 1020             


Ala Ser  Phe Ile Met Ser Tyr  Trp Lys Pro Glu Val  Met Ile Ala 
    1025                 1030                 1035             


Ala Gln  Gly Pro Leu Lys Glu  Thr Ile Gly Asp Phe  Trp Gln Met 
    1040                 1045                 1050             


Ile Phe  Gln Arg Lys Val Lys  Val Ile Val Met Leu  Thr Glu Leu 
    1055                 1060                 1065             


Lys His  Gly Asp Gln Glu Ile  Cys Ala Gln Tyr Trp  Gly Glu Gly 
    1070                 1075                 1080             


Lys Gln  Thr Tyr Gly Asp Ile  Glu Val Asp Met Lys  Asp Thr Asn 
    1085                 1090                 1095             


Lys Ser  Ser Thr Tyr Thr Leu  Arg Val Phe Glu Leu  Arg His Ser 
    1100                 1105                 1110             


Lys Arg  Lys Asp Ser Arg Thr  Val Tyr Gln Tyr Gln  Tyr Thr Asn 
    1115                 1120                 1125             


Trp Ser  Val Glu Gln Leu Pro  Ala Glu Pro Lys Glu  Leu Val Ser 
    1130                 1135                 1140             


Leu Ile  Gln Val Leu Lys Glu  Lys Leu Pro Gln Lys  Asn Phe Ser 
    1145                 1150                 1155             


Glu Gly  Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 
    1160                 1165                 1170             


Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 
    1175                 1180                 1185             


Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 
    1190                 1195                 1200             


Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 
    1205                 1210                 1215             


Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Ile Ile Ala  Ser Thr Tyr 
    1220                 1225                 1230             


Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 
    1235                 1240                 1245             


Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 
    1250                 1255                 1260             


Asn Cys  Val Asn Pro Leu Gly  Ala Thr Glu Lys Leu  Pro Glu Ala 
    1265                 1270                 1275             


Lys Glu  Gln Ala Thr Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 
    1280                 1285                 1290             


Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210>  146
<211>  1310
<212>  PRT
<213>  Macaca mulatta

<400>  146

Met Thr Met Cys Leu Trp Leu Lys Leu Leu Ala Phe Val Phe Ala Phe 
1               5                   10                  15      


Leu Asp Thr Glu Val Phe Val Thr Gly Gln Gly Ser Thr Leu Ser Pro 
            20                  25                  30          


Thr Gly Arg Arg Thr Thr Lys Met Pro Ser Val Pro Leu Ser Ser Asp 
        35                  40                  45              


Pro Leu Pro Thr His Thr Thr Ala Phe Ser Pro Ala Ser Ile Ser Glu 
    50                  55                  60                  


Arg Glu Asn Asp Phe Ser Glu Thr Thr Pro Ser Leu Ser Ser Asp Asn 
65                  70                  75                  80  


Thr Ser Thr His Val Ser Pro Asp Ser Leu Asp Asn Ala Ser Ala Phe 
                85                  90                  95      


Asn Thr Thr Gly Val Ser Ser Ala Leu Thr Pro His Leu Pro Thr His 
            100                 105                 110         


Ala Asp Ser Gln Thr Pro Ser Thr Gly Thr Asp Thr Gln Thr Pro Ser 
        115                 120                 125             


Gly Ser Ala Ala Asn Thr Thr Leu Ser Pro Thr Pro Arg Ser Asn Asp 
    130                 135                 140                 


Ile Ser Asp Val Pro Gly Glu Arg Ser Thr Ala Ser Thr Phe Pro Thr 
145                 150                 155                 160 


Asp Pro Ile Ser Pro Leu Ala Thr Thr Leu Ile Pro Ala Arg Asn Ser 
                165                 170                 175     


Ser Ala Ala Leu Pro Ala Arg Thr Ser Asn Thr Thr Ile Thr Ala Asn 
            180                 185                 190         


Thr Ser Val Ser Tyr Leu Asn Ala Ser Glu Thr Thr Thr Pro Ser Pro 
        195                 200                 205             


Ser Gly Ser Thr Val Ile Ser Thr Pro Thr Ile Ala Thr Thr Thr Ser 
    210                 215                 220                 


Lys Pro Thr Cys Ala Glu Lys Tyr Ala Thr Ile Pro Val Asp Tyr Leu 
225                 230                 235                 240 


Tyr Asn Asn Lys Thr Lys Leu Phe Thr Ala Lys Leu Asn Val Asn Glu 
                245                 250                 255     


Asn Val Glu Cys Thr Asn Asn Asn His Thr His Asn Ile Cys Thr Asn 
            260                 265                 270         


Asn Glu Val Leu Asn Leu Pro Glu Cys Lys Glu Met Asn Val Phe Val 
        275                 280                 285             


Ser His Asn Ser Cys Thr Asp Arg His Lys Glu Leu Lys Leu Asp Val 
    290                 295                 300                 


Pro Pro Glu Val Glu Lys Phe Gln Leu Asp Asp Cys Thr Pro Asp Val 
305                 310                 315                 320 


Glu Ala Asn Thr Thr Ile Cys Leu Lys Trp Lys Ile Ile Glu Thr Phe 
                325                 330                 335     


Ala Cys Asp Lys Ser Lys Ile Thr Tyr Arg Phe Gln Cys Gly Asn Lys 
            340                 345                 350         


Thr Tyr Asn Lys Glu Gly Ile Tyr Leu Glu Asn Leu Glu Pro Glu Tyr 
        355                 360                 365             


Glu Tyr Lys Cys Asp Ser Glu Ile Leu Tyr Asn Asn His Lys Tyr Ile 
    370                 375                 380                 


Asn Ile Thr Lys Leu Ile Lys Thr Asp Phe Gly Ile Pro Gly Gln Pro 
385                 390                 395                 400 


Gln Asn Val Val Cys Arg His Glu Asp Ala His Gln Gly Val Ile Thr 
                405                 410                 415     


Trp Asn Pro Pro Gln Arg Ser Phe His Asn Phe Thr Leu Cys Tyr Val 
            420                 425                 430         


Ser Lys Thr Ala Lys Lys Cys Leu Ser Leu Asp Lys His Leu Thr Thr 
        435                 440                 445             


Tyr His Leu Gln Asn Leu Lys Pro Tyr Thr Asn Tyr Ser Leu Ser Leu 
    450                 455                 460                 


His Ala Tyr Ile Ile Ala Lys Val Gln Arg Asn Gly Thr Ala Ala Thr 
465                 470                 475                 480 


Cys Asn Phe Thr Thr Glu Ser Ala Pro Pro Ser Gln Val Gln Asn Met 
                485                 490                 495     


Ile Val Ser Thr Ser Asp Asn Ser Met Arg Val Lys Cys Glu Ala Pro 
            500                 505                 510         


Arg Asp Val Asn Gly Pro Thr Glu Leu Tyr Leu Leu Glu Val Glu Ala 
        515                 520                 525             


Gly Asn Thr Leu Val Arg Asn Leu Ser Gln Ser Glu Cys Asp Phe Ser 
    530                 535                 540                 


Val Asn Asn Leu Gln Tyr Ser Thr Tyr Tyr Asn Leu Lys Ala Tyr Tyr 
545                 550                 555                 560 


His Asn Gly Lys Tyr Ser Gly Glu Pro Val Ile Leu Arg Glu Ser Thr 
                565                 570                 575     


Ser Tyr Asn Ser Lys Ala Leu Ile Ala Phe Leu Ala Phe Leu Ile Ile 
            580                 585                 590         


Val Thr Ser Ile Ala Leu Leu Val Val Leu Tyr Lys Ile Tyr Asp Leu 
        595                 600                 605             


His Lys Lys Arg Ser Cys Asn Leu Asp Glu Gln Gln Glu Leu Val Glu 
    610                 615                 620                 


Arg Asp Asp Glu Lys Gln Leu Met Asn Val Glu Pro Ile His Ala Asp 
625                 630                 635                 640 


Ile Leu Leu Glu Thr Tyr Lys Arg Lys Ile Ala Asp Glu Gly Arg Leu 
                645                 650                 655     


Phe Leu Ala Glu Phe Gln Ser Ile Pro Arg Val Phe Ser Lys Phe Pro 
            660                 665                 670         


Ile Lys Glu Ala Arg Lys Pro Phe Asn Gln Asn Lys Asn Arg Tyr Val 
        675                 680                 685             


Asp Ile Leu Pro Tyr Asp Tyr Asn Arg Val Glu Leu Ser Glu Ile Asn 
    690                 695                 700                 


Gly Asp Ala Gly Ser Asn Tyr Ile Asn Ala Ser Tyr Ile Asp Gly Phe 
705                 710                 715                 720 


Lys Glu Pro Arg Lys Tyr Ile Ala Ala Gln Gly Pro Arg Asp Glu Thr 
                725                 730                 735     


Val Asp Asp Phe Trp Arg Met Ile Trp Glu Gln Lys Ala Thr Val Ile 
            740                 745                 750         


Val Met Val Thr Arg Cys Glu Glu Gly Asn Arg Asn Lys Cys Ala Glu 
        755                 760                 765             


Tyr Trp Pro Ser Met Glu Glu Gly Thr Arg Ala Phe Gly Asp Val Val 
    770                 775                 780                 


Val Lys Ile Asn Gln His Lys Arg Cys Pro Asp Tyr Ile Ile Gln Lys 
785                 790                 795                 800 


Leu Asn Ile Val Asn Lys Lys Glu Lys Ala Thr Gly Arg Glu Val Thr 
                805                 810                 815     


His Ile Gln Phe Thr Ser Trp Pro Asp His Gly Val Pro Glu Asp Pro 
            820                 825                 830         


His Leu Leu Leu Lys Leu Arg Arg Arg Val Asn Ala Phe Ser Asn Phe 
        835                 840                 845             


Phe Ser Gly Pro Ile Val Val His Cys Ser Ala Gly Val Gly Arg Thr 
    850                 855                 860                 


Gly Thr Tyr Ile Gly Ile Asp Ala Met Leu Glu Gly Leu Glu Ala Glu 
865                 870                 875                 880 


Asn Lys Val Asp Val Tyr Gly Tyr Val Val Lys Leu Arg Arg Gln Arg 
                885                 890                 895     


Cys Leu Met Val Gln Val Glu Ala Gln Tyr Ile Leu Ile His Gln Ala 
            900                 905                 910         


Leu Val Glu Tyr Asn Gln Phe Gly Glu Thr Glu Val Asn Leu Ser Glu 
        915                 920                 925             


Leu His Pro Tyr Leu His Asn Met Lys Lys Arg Asp Pro Pro Ser Glu 
    930                 935                 940                 


Pro Ser Pro Leu Glu Ala Glu Phe Gln Arg Leu Pro Ser Tyr Arg Ser 
945                 950                 955                 960 


Trp Arg Thr Gln His Ile Gly Asn Gln Glu Glu Asn Lys Asn Lys Asn 
                965                 970                 975     


Arg Asn Ser Asn Val Ile Pro Tyr Asp Tyr Asn Arg Val Pro Leu Lys 
            980                 985                 990         


His Glu Leu Glu Met Ser Lys Glu  Ser Asp His Asp Ser  Asp Glu Ser 
        995                 1000                 1005             


Ser Asp  Asp Asp Ser Asp Ser  Glu Glu Pro Ser Lys  Tyr Ile Asn 
    1010                 1015                 1020             


Ala Ser  Phe Ile Met Ser Tyr  Trp Lys Pro Glu Val  Met Ile Ala 
    1025                 1030                 1035             


Ala Gln  Gly Pro Leu Lys Glu  Thr Ile Gly Asp Phe  Trp Gln Met 
    1040                 1045                 1050             


Ile Phe  Gln Arg Lys Val Lys  Val Ile Val Met Leu  Thr Glu Leu 
    1055                 1060                 1065             


Lys His  Gly Asp Gln Glu Ile  Cys Ala Gln Tyr Trp  Gly Glu Gly 
    1070                 1075                 1080             


Lys Gln  Thr Tyr Gly Asp Ile  Glu Val Asp Met Lys  Asp Thr Asn 
    1085                 1090                 1095             


Lys Ser  Ser Thr Tyr Thr Leu  Arg Val Phe Glu Leu  Arg His Ser 
    1100                 1105                 1110             


Lys Arg  Lys Asp Ser Arg Thr  Val Tyr Gln Tyr Gln  Tyr Thr Asn 
    1115                 1120                 1125             


Trp Ser  Val Glu Gln Leu Pro  Ala Glu Pro Lys Glu  Leu Val Ser 
    1130                 1135                 1140             


Leu Ile  Gln Val Leu Lys Glu  Lys Leu Pro Gln Lys  Asn Ser Ser 
    1145                 1150                 1155             


Glu Gly  Asn Lys His His Lys  Ser Thr Pro Leu Leu  Ile His Cys 
    1160                 1165                 1170             


Arg Asp  Gly Ser Gln Gln Thr  Gly Ile Phe Cys Ala  Leu Leu Asn 
    1175                 1180                 1185             


Leu Leu  Glu Ser Ala Glu Thr  Glu Glu Val Val Asp  Ile Phe Gln 
    1190                 1195                 1200             


Val Val  Lys Ala Leu Arg Lys  Ala Arg Pro Gly Met  Val Ser Thr 
    1205                 1210                 1215             


Phe Glu  Gln Tyr Gln Phe Leu  Tyr Asp Ile Ile Ala  Ser Thr Tyr 
    1220                 1225                 1230             


Pro Ala  Gln Asn Gly Gln Val  Lys Lys Asn Asn His  Gln Glu Asp 
    1235                 1240                 1245             


Lys Ile  Glu Phe Asp Asn Glu  Val Asp Lys Val Lys  Gln Asp Ala 
    1250                 1255                 1260             


Asn Cys  Val Asn Pro Leu Gly  Ala Thr Glu Lys Leu  Pro Glu Ala 
    1265                 1270                 1275             


Lys Glu  Gln Ala Thr Gly Ser  Glu Pro Thr Ser Gly  Thr Glu Gly 
    1280                 1285                 1290             


Pro Glu  His Ser Val Asn Gly  Pro Ala Ser Pro Ala  Leu Asn Gln 
    1295                 1300                 1305             


Gly Ser  
    1310 


<210>  147
<211>  293
<212>  PRT
<213>  Escherichia coli

<400>  147

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  148
<211>  293
<212>  PRT
<213>  Shigella dysenteriae

<400>  148

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  149
<211>  297
<212>  PRT
<213>  Escherichia coli

<400>  149

Asp Glu Phe Thr Val Asp Phe Ser Ser Gln Lys Ser Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Ser Ile Arg Ser Ala Ile Ser Thr Pro Leu Gly Asn Ile Ser 
            20                  25                  30          


Gln Gly Gly Val Ser Val Ser Val Ile Asn His Val Leu Gly Gly Asn 
        35                  40                  45              


Tyr Ile Ser Leu Asn Val Arg Gly Leu Asp Pro Tyr Ser Glu Arg Phe 
    50                  55                  60                  


Asn His Leu Arg Leu Ile Met Glu Arg Asn Asn Leu Tyr Val Ala Gly 
65                  70                  75                  80  


Phe Ile Asn Thr Glu Thr Asn Ile Phe Tyr Arg Phe Ser Asp Phe Ser 
                85                  90                  95      


His Ile Ser Val Pro Asp Val Ile Thr Val Ser Met Thr Thr Asp Ser 
            100                 105                 110         


Ser Tyr Ser Ser Leu Gln Arg Ile Ala Asp Leu Glu Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Gly Arg His Ser Leu Val Gly Ser Tyr Leu Asp Leu Met Glu 
    130                 135                 140                 


Phe Arg Gly Arg Ser Met Thr Arg Ala Ser Ser Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Ile Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Pro Ala Leu Ser Glu Ala Ser Pro Leu Tyr Thr Met Thr 
            180                 185                 190         


Ala Gln Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Ile Ser Asn Val 
        195                 200                 205             


Leu Pro Glu Tyr Arg Gly Glu Glu Gly Val Arg Ile Gly Arg Ile Ser 
    210                 215                 220                 


Phe Asn Ser Leu Ser Ala Ile Leu Gly Ser Val Ala Val Ile Leu Asn 
225                 230                 235                 240 


Cys His Ser Thr Gly Ser Tyr Ser Val Arg Ser Val Ser Gln Lys Gln 
                245                 250                 255     


Lys Thr Glu Cys Gln Ile Val Gly Asp Arg Ala Ala Ile Lys Val Asn 
            260                 265                 270         


Asn Val Leu Trp Glu Ala Asn Thr Ile Ala Ala Leu Leu Asn Arg Lys 
        275                 280                 285             


Pro Gln Asp Leu Thr Glu Pro Asn Gln 
    290                 295         


<210>  150
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  150
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcgaa gcatatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtctca gtggtgccac catacactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt attactgcgc cagaggtgga      300

caatactact acgacagcag tgattacggt gaggtagcat tcgacatatg gggtcagggt      360

acaatggtca ccgtctcctc a                                                381


<210>  151
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  151
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctggtc agtaatggat acaactattt ggattggtac      120

ctgcagaagc cagggcagtc tccacagctc ctgatctatt tcggttcttc ccgggcctcc      180

ggggtccctg acaggttcag tggcagtgga tcaggcacag attttacact gaaaatcagc      240

agagtggagg ctgaggatgt tggggtttat tactgcatgc agagaagacg cactccttgg      300

tcttttggcg gagggaccaa ggttgagatc aaa                                   333


<210>  152
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  152
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcgga ggatatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtatca gtggtgccac cataacctac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc cagaggtgga      300

caatactact acgacagcag cgattatggt gaggtagcat tcgacatatg gggtcagggt      360

acaatggtca ccgtctcctc a                                                381


<210>  153
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  153
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctggtc agtaatggat acaactattt ggattggtac      120

ctgcagaagc cagggcagtc tccacagctc ctgatctatt tcggttcttc ccgggcctcc      180

ggggtccctg acaggttcag tggcagtgga tcaggcacag attttacact gaaaatcagc      240

agagtggagg ctgaggatgt tggggtttat tactgcatgc agagaagacg cactcctcct      300

ttcacttttg gcggagggac caaggttgag atcaaa                                336


<210>  154
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  154
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcgaa gcatatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtctca gtggtgccac catacactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt attactgcgc cagaggtgga      300

caatactact acacgagcag tgattacggt gaggtagcat tcgacatatg gggtcagggt      360

acaatggtca ccgtctcctc a                                                381


<210>  155
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  155
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctggtc agtaatggat acaactattt ggattggtac      120

ctgcagaagc cagggcagtc tccacagctc ctgatctatt tcggttcttc ccgggcctcc      180

ggggtccctg acaggttcag tggcagtgga tcaggcacag attttacact gaaaatcagc      240

agagtggagg ctgaggatgt tggggtttat tactgcatgc agagaagacg cactccttgg      300

tcttttggcg gagggaccaa ggttgagatc aaa                                   333


<210>  156
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  156
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggcgggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaat aattattgga tgacatgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatct attagttcca gtggtggtag catttactac      180

cccgacaggg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgc aagagacgag      300

agatgggcag gtgctatgga tgcctggggg caagggacca cggtcaccgt ctcctca         357


<210>  157
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  157
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggcaagtca gaatattaac aagaatttag actggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgag acgaataact tgcaaacagg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgttatcag cataattcta gatttacttt tggccagggg      300

accaagctgg agatcaaa                                                    318


<210>  158
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  158
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttacc aatttttgga tggcgtggat ccgccaggct      120

ccagggaagg ggctggagtg ggtcgcaagt attagttcaa gtggtggtag catctactac      180

cctgactccg tgaaggaccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggcggtgt actactgcgt caagtttcac      300

cactattcag gcggcggcga tgcttggggc caagggaccc tggtcaccgt ctcctca         357


<210>  159
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  159
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aagcaagtca gaatattaac aagtatttag attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatccattac actaacaact tgcacaccgg gattccatca      180

aggttcagtg gcagtggatc tgggacagat tatactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtctgcag cacagttcca gatggacatt cggcggaggg      300

accaaggtgg agatcaaa                                                    318


<210>  160
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  160
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcaat aactattgga tgacgtgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatcc attagtagta gtggcggtag tatatactac      180

cctgactctg tgaaggatcg attcaccatc tccagagaca atgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agctgaggac atggcggtgt actactgcgc caggttgtac      300

tactacgacg ggggagggga tgcgtggggc caaggaaccc tggtcaccgt ctcctca         357


<210>  161
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide

<400>  161
ggcatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aggcgagtca ggacattaat aagtatttag attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctacaat acaaacaatt tgcatacagg gatcccatca      180

aggttcagtg gaagtggatc tgggacagat tatactctta ccatcagcag cctgcagcct      240

gaagattttg caacatatta ctgtcttcaa cacatatcta gatggacgtt cggcggaggg      300

accaaggtgg agatcaaa                                                    318


