                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Posey, Avery D.
       King, Tiffany
 
<120>  Fibronectin Targeting Chimeric Antigen Receptors (CARs)

<130>  046483-7284WO1(02430)

<150>  U.S. Provisional Patent Application No. 62/929,575
<151>  2019-11-01

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 HCDR1

<400>  1

Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly 
1               5                   10      


<210>  2
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 HCDR2

<400>  2

Trp Leu Ala His Ile Trp Trp Asp Asp Thr Arg Arg Tyr 
1               5                   10              


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 HCDR3

<400>  3

Ala Arg Met Asn Gly Asn Tyr Pro Ala Trp Phe Ala Tyr 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 LCDR1

<400>  4

Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10              


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 LCDR2

<400>  5

Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
1               5                   10      


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 LCDR3

<400>  6

Phe Gln Gly Ser His Ile Pro Pro 
1               5               


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 VH

<400>  7

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Thr Arg Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Asn Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Asn Gly Asn Tyr Pro Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 VL

<400>  8

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Leu Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  10
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 scFv (HL)

<400>  10

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Thr Arg Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Asn Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Asn Gly Asn Tyr Pro Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Leu Met Thr Gln Thr Pro 
    130                 135                 140                 


Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg 
145                 150                 155                 160 


Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp 
                165                 170                 175     


Tyr Leu Leu Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val 
            180                 185                 190         


Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu 
    210                 215                 220                 


Gly Ile Tyr Tyr Cys Phe Gln Gly Ser His Ile Pro Pro Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Lys 
                245             


<210>  11
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 scFv (LH)

<400>  11

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Leu Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly 
145                 150                 155                 160 


Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Leu Ala His Ile Trp Trp Asp Asp Thr Arg Arg Tyr Asn Pro Ala Leu 
            180                 185                 190         


Lys Ser Arg Leu Thr Ile Ser Asn Asp Thr Ser Asn Asn Gln Val Phe 
        195                 200                 205             


Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Met Asn Gly Asn Tyr Pro Ala Trp Phe Ala Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Leu Val Thr Val Ser Ser 
                245             


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 HCDR1

<400>  12

Leu Thr Phe Asn Thr Tyr Ala Met Asn 
1               5                   


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 HCDR2

<400>  13

Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr 
1               5                   10                  15      


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 HCDR3

<400>  14

Lys Gln Gly Gly Asn Ser Leu Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 LCDR1

<400>  15

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala 
1               5                   10                  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 LCDR2

<400>  16

Leu Leu Ile Tyr Trp Ala Ser Thr Gly Glu Ser 
1               5                   10      


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 LCDR3

<400>  17

Gln Gln Tyr Tyr Ser Tyr Pro Leu 
1               5               


<210>  18
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 VH

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Leu Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Arg Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Lys Gln Gly Gly Asn Ser Leu Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  19
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 VL

<400>  19

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Gly Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  20

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Ser 
1               5                   10                  15      


Lys Gly 
        


<210>  21
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 scFv (HL)

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Leu Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Arg Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Lys Gln Gly Gly Asn Ser Leu Tyr Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Ser Thr 
        115                 120                 125             


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Ser Lys Gly Gly 
    130                 135                 140                 


Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val 
145                 150                 155                 160 


Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr 
                165                 170                 175     


Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly 
            180                 185                 190         


Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Gly Glu Ser Gly 
        195                 200                 205             


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 


Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
                245                 250                 255     


Leu Lys 
        


<210>  22
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 scFv (LH)

<400>  22

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Gly Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
        115                 120                 125             


Ser Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Lys Gly Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Leu Thr Phe 
145                 150                 155                 160 


Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Arg Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser 
        195                 200                 205             


Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 
    210                 215                 220                 


Ala Met Tyr Tyr Cys Val Lys Gln Gly Gly Asn Ser Leu Tyr Trp Tyr 
225                 230                 235                 240 


Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 HCDR1

<400>  23

Phe Thr Phe Ser Ser Phe Ser Met Ser 
1               5                   


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 HCDR2

<400>  24

Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr 
1               5                   10                  


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 HCDR3

<400>  25

Lys Pro Phe Pro Tyr Phe Asp Tyr 
1               5               


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 LCDR1

<400>  26

Gln Ser Val Ser Ser Ser Phe Leu Ala 
1               5                   


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 LCDR2

<400>  27

Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr 
1               5                   10      


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 LCDR3

<400>  28

Gln Gln Thr Gly Arg Ile Pro Pro 
1               5               


<210>  29
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 VH

<400>  29

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  30
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 VL

<400>  30

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  31
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 scFv (HL)

<400>  31

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 
    130                 135                 140                 


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
145                 150                 155                 160 


Ser Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
                165                 170                 175     


Arg Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        195                 200                 205             


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly 
    210                 215                 220                 


Arg Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 


<210>  32
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 scFv (LH)

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly 
                165                 170                 175     


Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro 
    210                 215                 220                 


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235                 


<210>  33
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8? Leader

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  34
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8? Hinge

<400>  34

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  35
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8? Transmembrane

<400>  35

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  36
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB ICD

<400>  36

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  37
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3?

<400>  37

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  38
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 CAR (HL)

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Thr Leu Lys Glu Ser Gly Pro 
            20                  25                  30          


Gly Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser 
        35                  40                  45              


Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln 
    50                  55                  60                  


Pro Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp 
65                  70                  75                  80  


Thr Arg Arg Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Asn 
                85                  90                  95      


Asp Thr Ser Asn Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr 
            100                 105                 110         


Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met Asn Gly Asn Tyr Pro 
        115                 120                 125             


Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp 
                165                 170                 175     


Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser Asn 
            180                 185                 190         


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Leu Lys Pro Gly Gln Ser Pro 
        195                 200                 205             


Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly Ser 
                245                 250                 255     


His Ile Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ser 
            260                 265                 270         


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  39
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FDC-6 CAR (LH)

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Val Leu Met Thr Gln Thr Pro Leu 
            20                  25                  30          


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
        35                  40                  45              


Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
    50                  55                  60                  


Leu Leu Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
65                  70                  75                  80  


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            100                 105                 110         


Ile Tyr Tyr Cys Phe Gln Gly Ser His Ile Pro Pro Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
145                 150                 155                 160 


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
                165                 170                 175     


Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro 
            180                 185                 190         


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Thr 
        195                 200                 205             


Arg Arg Tyr Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Asn Asp 
    210                 215                 220                 


Thr Ser Asn Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala 
225                 230                 235                 240 


Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met Asn Gly Asn Tyr Pro Ala 
                245                 250                 255     


Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser 
            260                 265                 270         


Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  40
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 CAR (HL)

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Lys Gly Ser Leu Lys Ile Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Leu Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Arg Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn 
65                  70                  75                  80  


Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser 
                85                  90                  95      


Arg Asp Asp Ser Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys 
            100                 105                 110         


Thr Glu Asp Thr Ala Met Tyr Tyr Cys Val Lys Gln Gly Gly Asn Ser 
        115                 120                 125             


Leu Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Ser Gly Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
145                 150                 155                 160 


Glu Gly Ser Ser Lys Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro 
                165                 170                 175     


Ser Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys 
            180                 185                 190         


Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala 
        195                 200                 205             


Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp 
    210                 215                 220                 


Ala Ser Thr Gly Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly 
225                 230                 235                 240 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp 
                245                 250                 255     


Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe 
            260                 265                 270         


Gly Ala Gly Thr Lys Leu Glu Leu Lys Ser Gly Thr Thr Thr Pro Ala 
        275                 280                 285             


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
    290                 295                 300                 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
305                 310                 315                 320 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                325                 330                 335     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            340                 345                 350         


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
        355                 360                 365             


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
    370                 375                 380                 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
385                 390                 395                 400 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
                405                 410                 415     


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
            420                 425                 430         


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
        435                 440                 445             


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
    450                 455                 460                 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
465                 470                 475                 480 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
                485                 490                 495     


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505     


<210>  41
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6 CAR (LH)

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser 
        35                  40                  45              


Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp 
    50                  55                  60                  


Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala 
65                  70                  75                  80  


Ser Thr Gly Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser 
                85                  90                  95      


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu 
            100                 105                 110         


Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly 
        115                 120                 125             


Ala Gly Thr Lys Leu Glu Leu Lys Gly Ser Thr Ser Gly Ser Gly Lys 
    130                 135                 140                 


Pro Gly Ser Gly Glu Gly Ser Ser Lys Gly Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Leu Val Gln Pro Lys Gly Ser Leu Lys Ile Ser Cys 
                165                 170                 175     


Ala Ala Ser Gly Leu Thr Phe Asn Thr Tyr Ala Met Asn Trp Val Arg 
            180                 185                 190         


Gln Ala Pro Arg Lys Gly Leu Glu Trp Val Ala Arg Ile Arg Ser Lys 
        195                 200                 205             


Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asp Ser Gln Ser Met Leu Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Val Lys Gln Gly 
                245                 250                 255     


Gly Asn Ser Leu Tyr Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
            260                 265                 270         


Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro 
        275                 280                 285             


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
    290                 295                 300                 


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
305                 310                 315                 320 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
                325                 330                 335     


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
            340                 345                 350         


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
        355                 360                 365             


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
    370                 375                 380                 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
385                 390                 395                 400 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
                405                 410                 415     


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
            420                 425                 430         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
        435                 440                 445             


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
    450                 455                 460                 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
465                 470                 475                 480 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
                485                 490                 495     


Gln Ala Leu Pro Pro Arg 
            500         


<210>  42
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 CAR (HL)

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr 
65                  70                  75                  80  


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
145                 150                 155                 160 


Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
                165                 170                 175     


Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Ser 
        195                 200                 205             


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  43
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L19 CAR (LH)

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 
            20                  25                  30          


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        35                  40                  45              


Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Ser Arg Ala Thr 
65                  70                  75                  80  


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                165                 170                 175     


Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  44
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FDC-6 VH nucleotide sequence

<400>  44
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtagg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg gcacacattt ggtgggatga taccaggcgc      180

tataacccag ccctgaagag ccgactgaca atctccaatg atacctccaa caaccaggta      240

tttctcaaga tcgccagtgt ggacactgca gatactgcca catactattg tgctcgaatg      300

aacggtaact accctgcctg gtttgcttac tggggccaag ggactctggt cactgtctct      360

tca                                                                    363


<210>  45
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FDC-6 VL nucleotide sequence

<400>  45
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaacattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgctga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggagtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatt tattactgct ttcaaggttc acatattcct      300

ccgacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  46
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FDC-6 scFv (HL) nucleotide sequence

<400>  46
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtagg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg gcacacattt ggtgggatga taccaggcgc      180

tataacccag ccctgaagag ccgactgaca atctccaatg atacctccaa caaccaggta      240

tttctcaaga tcgccagtgt ggacactgca gatactgcca catactattg tgctcgaatg      300

aacggtaact accctgcctg gtttgcttac tggggccaag ggactctggt cactgtctct      360

tcaggtggcg gagggagcgg cggtggagga agcggaggcg gaggttccga tgttttgatg      420

acccaaactc cactctccct gcctgtcagt cttggagatc aagcctccat ctcttgcaga      480

tctagtcaga acattgtaca tagtaatgga aacacctatt tagaatggta cctgctgaaa      540

ccaggccagt ctccaaagct cctgatctac aaagtttcca accgattttc tggagtccca      600

gacaggttca gtggcagtgg atcagggaca gatttcacac tcaagatcag cagagtggag      660

gctgaggatc tgggaattta ttactgcttt caaggttcac atattcctcc gacgttcggt      720

ggaggcacca agctggaaat caaa                                             744


<210>  47
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FDC-6 scFv (LH) nucleotide sequence

<400>  47
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaacattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgctga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggagtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatt tattactgct ttcaaggttc acatattcct      300

ccgacgttcg gtggaggcac caagctggaa atcaaaggtg gcggagggag cggcggtgga      360

ggaagcggag gcggaggttc ccaggttact ctgaaagagt ctggccctgg gatattgcag      420

ccctcccaga ccctcagtct gacttgttct ttctctgggt tttcactgag cacttctggt      480

atgggtgtag gctggattcg tcagccttca gggaagggtc tggagtggct ggcacacatt      540

tggtgggatg ataccaggcg ctataaccca gccctgaaga gccgactgac aatctccaat      600

gatacctcca acaaccaggt atttctcaag atcgccagtg tggacactgc agatactgcc      660

acatactatt gtgctcgaat gaacggtaac taccctgcct ggtttgctta ctggggccaa      720

gggactctgg tcactgtctc ttca                                             744


<210>  48
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FDC-6 CAR (HL) nucleotide sequence

<400>  48
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccc aggttactct gaaagagtct ggccctggga tattgcagcc ctcccagacc      120

ctcagtctga cttgttcttt ctctgggttt tcactgagca cttctggtat gggtgtaggc      180

tggattcgtc agccttcagg gaagggtctg gagtggctgg cacacatttg gtgggatgat      240

accaggcgct ataacccagc cctgaagagc cgactgacaa tctccaatga tacctccaac      300

aaccaggtat ttctcaagat cgccagtgtg gacactgcag atactgccac atactattgt      360

gctcgaatga acggtaacta ccctgcctgg tttgcttact ggggccaagg gactctggtc      420

actgtctctt caggtggcgg agggagcggc ggtggaggaa gcggaggcgg aggttccgat      480

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      540

tcttgcagat ctagtcagaa cattgtacat agtaatggaa acacctattt agaatggtac      600

ctgctgaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      660

ggagtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      720

agagtggagg ctgaggatct gggaatttat tactgctttc aaggttcaca tattcctccg      780

acgttcggtg gaggcaccaa gctggaaatc aaatccggaa ccacgacgcc agcgccgcga      840

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      960

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     1020

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1080

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1140

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     1200

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1260

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     1320

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1380

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     1440

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgc                  1488


<210>  49
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FDC-6 CAR (LH) nucleotide sequence

<400>  49
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg atgttttgat gacccaaact ccactctccc tgcctgtcag tcttggagat      120

caagcctcca tctcttgcag atctagtcag aacattgtac atagtaatgg aaacacctat      180

ttagaatggt acctgctgaa accaggccag tctccaaagc tcctgatcta caaagtttcc      240

aaccgatttt ctggagtccc agacaggttc agtggcagtg gatcagggac agatttcaca      300

ctcaagatca gcagagtgga ggctgaggat ctgggaattt attactgctt tcaaggttca      360

catattcctc cgacgttcgg tggaggcacc aagctggaaa tcaaaggtgg cggagggagc      420

ggcggtggag gaagcggagg cggaggttcc caggttactc tgaaagagtc tggccctggg      480

atattgcagc cctcccagac cctcagtctg acttgttctt tctctgggtt ttcactgagc      540

acttctggta tgggtgtagg ctggattcgt cagccttcag ggaagggtct ggagtggctg      600

gcacacattt ggtgggatga taccaggcgc tataacccag ccctgaagag ccgactgaca      660

atctccaatg atacctccaa caaccaggta tttctcaaga tcgccagtgt ggacactgca      720

gatactgcca catactattg tgctcgaatg aacggtaact accctgcctg gtttgcttac      780

tggggccaag ggactctggt cactgtctct tcatccggaa ccacgacgcc agcgccgcga      840

ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc      900

cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac      960

atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt     1020

tactgcaaac ggggcagaaa gaaactcctg tatatattca aacaaccatt tatgagacca     1080

gtacaaacta ctcaagagga agatggctgt agctgccgat ttccagaaga agaagaagga     1140

ggatgtgaac tgagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     1200

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1260

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     1320

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1380

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     1440

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgc                  1488


<210>  50
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C6 VH nucleotide sequence

<400>  50
gaggtccaat tggtagagag tggcggcggc ctcgtccagc caaaaggttc cttgaagata       60

agctgtgccg catcaggact gacgttcaac acctatgcca tgaactgggt ccggcaggca      120

ccacgcaagg gccttgagtg ggtcgcaaga ataaggtcta agtccaataa ctacgcgact      180

tactacgcgg atagtgtaaa ggatcgcttc acaatatcac gcgacgactc acaatcaatg      240

ttgtatctcc agatgaataa ccttaagaca gaggacactg ctatgtatta ttgcgtgaag      300

caaggcggga actcacttta ttggtacttt gatgtctggg gcgcgggcac gacggtcacc      360

gtttcttcc                                                              369


<210>  51
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C6 VL nucleotide sequence

<400>  51
gatatagtga tgagtcagag tccaagctcc ttggcggtga gtgtcgggga gaaggtcact       60

atgagctgca agtccagtca atccttgctc tattcttcta accaaaaaaa ttatttggcc      120

tggtatcaac aaagacctgg tcagtctccc aaacttttga tatattgggc atctaccggc      180

gaatctggcg ttcctgacag gtttaccggg agtgggtcag gaactgactt cactctcacg      240

atctctagtg tcaaagccga agatttggcc gtctattact gtcagcaata ttactcctat      300

cctctgacct ttggcgctgg cacaaagttg gagcttaag                             339


<210>  52
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C6 scFv (HL) nucleotide sequence

<400>  52
gaggtccaat tggtagagag tggcggcggc ctcgtccagc caaaaggttc cttgaagata       60

agctgtgccg catcaggact gacgttcaac acctatgcca tgaactgggt ccggcaggca      120

ccacgcaagg gccttgagtg ggtcgcaaga ataaggtcta agtccaataa ctacgcgact      180

tactacgcgg atagtgtaaa ggatcgcttc acaatatcac gcgacgactc acaatcaatg      240

ttgtatctcc agatgaataa ccttaagaca gaggacactg ctatgtatta ttgcgtgaag      300

caaggcggga actcacttta ttggtacttt gatgtctggg gcgcgggcac gacggtcacc      360

gtttcttccg gcagtacctc agggtccggc aagccaggta gtggcgaggg cagcagtaag      420

ggagatatag tgatgagtca gagtccaagc tccttggcgg tgagtgtcgg ggagaaggtc      480

actatgagct gcaagtccag tcaatccttg ctctattctt ctaaccaaaa aaattatttg      540

gcctggtatc aacaaagacc tggtcagtct cccaaacttt tgatatattg ggcatctacc      600

ggcgaatctg gcgttcctga caggtttacc gggagtgggt caggaactga cttcactctc      660

acgatctcta gtgtcaaagc cgaagatttg gccgtctatt actgtcagca atattactcc      720

tatcctctga cctttggcgc tggcacaaag ttggagctta ag                         762


<210>  53
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C6 scFv (LH) nucleotide sequence

<400>  53
gatatagtga tgagtcagag tccaagctcc ttggcggtga gtgtcgggga gaaggtcact       60

atgagctgca agtccagtca atccttgctc tattcttcta accaaaaaaa ttatttggcc      120

tggtatcaac aaagacctgg tcagtctccc aaacttttga tatattgggc atctaccggc      180

gaatctggcg ttcctgacag gtttaccggg agtgggtcag gaactgactt cactctcacg      240

atctctagtg tcaaagccga agatttggcc gtctattact gtcagcaata ttactcctat      300

cctctgacct ttggcgctgg cacaaagttg gagcttaagg gcagtacctc agggtccggc      360

aagccaggta gtggcgaggg cagcagtaag ggagaggtcc aattggtaga gagtggcggc      420

ggcctcgtcc agccaaaagg ttccttgaag ataagctgtg ccgcatcagg actgacgttc      480

aacacctatg ccatgaactg ggtccggcag gcaccacgca agggccttga gtgggtcgca      540

agaataaggt ctaagtccaa taactacgcg acttactacg cggatagtgt aaaggatcgc      600

ttcacaatat cacgcgacga ctcacaatca atgttgtatc tccagatgaa taaccttaag      660

acagaggaca ctgctatgta ttattgcgtg aagcaaggcg ggaactcact ttattggtac      720

tttgatgtct ggggcgcggg cacgacggtc accgtttctt cc                         762


<210>  54
<211>  1506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C6 CAR (HL) nucleotide sequence

<400>  54
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg aggtccaatt ggtagagagt ggcggcggcc tcgtccagcc aaaaggttcc      120

ttgaagataa gctgtgccgc atcaggactg acgttcaaca cctatgccat gaactgggtc      180

cggcaggcac cacgcaaggg ccttgagtgg gtcgcaagaa taaggtctaa gtccaataac      240

tacgcgactt actacgcgga tagtgtaaag gatcgcttca caatatcacg cgacgactca      300

caatcaatgt tgtatctcca gatgaataac cttaagacag aggacactgc tatgtattat      360

tgcgtgaagc aaggcgggaa ctcactttat tggtactttg atgtctgggg cgcgggcacg      420

acggtcaccg tttcttccgg cagtacctca gggtccggca agccaggtag tggcgagggc      480

agcagtaagg gagatatagt gatgagtcag agtccaagct ccttggcggt gagtgtcggg      540

gagaaggtca ctatgagctg caagtccagt caatccttgc tctattcttc taaccaaaaa      600

aattatttgg cctggtatca acaaagacct ggtcagtctc ccaaactttt gatatattgg      660

gcatctaccg gcgaatctgg cgttcctgac aggtttaccg ggagtgggtc aggaactgac      720

ttcactctca cgatctctag tgtcaaagcc gaagatttgg ccgtctatta ctgtcagcaa      780

tattactcct atcctctgac ctttggcgct ggcacaaagt tggagcttaa gtccggaacc      840

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      900

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      960

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg     1020

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     1080

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1140

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1200

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1260

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1320

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1380

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1440

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1500

cctcgc                                                                1506


<210>  55
<211>  1506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C6 CAR (LH) nucleotide sequence

<400>  55
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg atatagtgat gagtcagagt ccaagctcct tggcggtgag tgtcggggag      120

aaggtcacta tgagctgcaa gtccagtcaa tccttgctct attcttctaa ccaaaaaaat      180

tatttggcct ggtatcaaca aagacctggt cagtctccca aacttttgat atattgggca      240

tctaccggcg aatctggcgt tcctgacagg tttaccggga gtgggtcagg aactgacttc      300

actctcacga tctctagtgt caaagccgaa gatttggccg tctattactg tcagcaatat      360

tactcctatc ctctgacctt tggcgctggc acaaagttgg agcttaaggg cagtacctca      420

gggtccggca agccaggtag tggcgagggc agcagtaagg gagaggtcca attggtagag      480

agtggcggcg gcctcgtcca gccaaaaggt tccttgaaga taagctgtgc cgcatcagga      540

ctgacgttca acacctatgc catgaactgg gtccggcagg caccacgcaa gggccttgag      600

tgggtcgcaa gaataaggtc taagtccaat aactacgcga cttactacgc ggatagtgta      660

aaggatcgct tcacaatatc acgcgacgac tcacaatcaa tgttgtatct ccagatgaat      720

aaccttaaga cagaggacac tgctatgtat tattgcgtga agcaaggcgg gaactcactt      780

tattggtact ttgatgtctg gggcgcgggc acgacggtca ccgtttcttc ctccggaacc      840

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      900

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      960

ttcgcctgtg atatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg     1020

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     1080

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1140

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1200

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1260

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1320

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1380

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1440

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1500

cctcgc                                                                1506


<210>  56
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L19 VH nucleotide sequence

<400>  56
gaggtacagc tcttggagtc tgggggtggt ttggttcaac caggtggctc tctgcgcctg       60

tcctgtgcgg cttctggttt taccttctct tcattctcta tgtcctgggt tcgacaggca      120

cctggaaagg gactggagtg ggtttcctct ataagcggca gttctggcac gacgtattat      180

gccgactccg tcaagggaag gttcaccatt tctcgggata attcaaagaa cacactctac      240

ttgcagatga actcattgag agcagaagac acagcagtgt actattgtgc gaagcccttt      300

ccgtatttcg attactgggg ccagggcaca ttggttactg ttagcagt                   348


<210>  57
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L19 VL nucleotide sequence

<400>  57
gagatcgttt tgacacaatc tccgggcaca ctctctctca gtccaggcga acgcgcaact       60

ttgtcttgtc gagccagcca gagcgtttcc tcctcattcc ttgcgtggta tcagcagaag      120

ccgggccagg caccccgcct cctgatttac tacgcatcat ctagggcaac aggtattcct      180

gacaggttca gtggctcagg ctctggcaca gattttacac tcactatttc cagattggag      240

ccagaggatt ttgcggttta ctattgccag caaactgggc gaatcccacc gacattcgga      300

caaggtacga aggtcgaaat caag                                             324


<210>  58
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L19 scFv (HL) nucleotide sequence

<400>  58
gaggtacagc tcttggagtc tgggggtggt ttggttcaac caggtggctc tctgcgcctg       60

tcctgtgcgg cttctggttt taccttctct tcattctcta tgtcctgggt tcgacaggca      120

cctggaaagg gactggagtg ggtttcctct ataagcggca gttctggcac gacgtattat      180

gccgactccg tcaagggaag gttcaccatt tctcgggata attcaaagaa cacactctac      240

ttgcagatga actcattgag agcagaagac acagcagtgt actattgtgc gaagcccttt      300

ccgtatttcg attactgggg ccagggcaca ttggttactg ttagcagtgg tggcggaggg      360

agcggcggtg gaggaagcgg aggcggaggt tccgagatcg ttttgacaca atctccgggc      420

acactctctc tcagtccagg cgaacgcgca actttgtctt gtcgagccag ccagagcgtt      480

tcctcctcat tccttgcgtg gtatcagcag aagccgggcc aggcaccccg cctcctgatt      540

tactacgcat catctagggc aacaggtatt cctgacaggt tcagtggctc aggctctggc      600

acagatttta cactcactat ttccagattg gagccagagg attttgcggt ttactattgc      660

cagcaaactg ggcgaatccc accgacattc ggacaaggta cgaaggtcga aatcaag         717


<210>  59
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L19 scFv (LH) nucleotide sequence

<400>  59
gagatcgttt tgacacaatc tccgggcaca ctctctctca gtccaggcga acgcgcaact       60

ttgtcttgtc gagccagcca gagcgtttcc tcctcattcc ttgcgtggta tcagcagaag      120

ccgggccagg caccccgcct cctgatttac tacgcatcat ctagggcaac aggtattcct      180

gacaggttca gtggctcagg ctctggcaca gattttacac tcactatttc cagattggag      240

ccagaggatt ttgcggttta ctattgccag caaactgggc gaatcccacc gacattcgga      300

caaggtacga aggtcgaaat caagggtggc ggagggagcg gcggtggagg aagcggaggc      360

ggaggttccg aggtacagct cttggagtct gggggtggtt tggttcaacc aggtggctct      420

ctgcgcctgt cctgtgcggc ttctggtttt accttctctt cattctctat gtcctgggtt      480

cgacaggcac ctggaaaggg actggagtgg gtttcctcta taagcggcag ttctggcacg      540

acgtattatg ccgactccgt caagggaagg ttcaccattt ctcgggataa ttcaaagaac      600

acactctact tgcagatgaa ctcattgaga gcagaagaca cagcagtgta ctattgtgcg      660

aagccctttc cgtatttcga ttactggggc cagggcacat tggttactgt tagcagt         717


<210>  60
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L19 CAR (HL) nucleotide sequence

<400>  60
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg aggtacagct cttggagtct gggggtggtt tggttcaacc aggtggctct      120

ctgcgcctgt cctgtgcggc ttctggtttt accttctctt cattctctat gtcctgggtt      180

cgacaggcac ctggaaaggg actggagtgg gtttcctcta taagcggcag ttctggcacg      240

acgtattatg ccgactccgt caagggaagg ttcaccattt ctcgggataa ttcaaagaac      300

acactctact tgcagatgaa ctcattgaga gcagaagaca cagcagtgta ctattgtgcg      360

aagccctttc cgtatttcga ttactggggc cagggcacat tggttactgt tagcagtggt      420

ggcggaggga gcggcggtgg aggaagcgga ggcggaggtt ccgagatcgt tttgacacaa      480

tctccgggca cactctctct cagtccaggc gaacgcgcaa ctttgtcttg tcgagccagc      540

cagagcgttt cctcctcatt ccttgcgtgg tatcagcaga agccgggcca ggcaccccgc      600

ctcctgattt actacgcatc atctagggca acaggtattc ctgacaggtt cagtggctca      660

ggctctggca cagattttac actcactatt tccagattgg agccagagga ttttgcggtt      720

tactattgcc agcaaactgg gcgaatccca ccgacattcg gacaaggtac gaaggtcgaa      780

atcaagtccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210>  61
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L19 CAR (LH) nucleotide sequence

<400>  61
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg agatcgtttt gacacaatct ccgggcacac tctctctcag tccaggcgaa      120

cgcgcaactt tgtcttgtcg agccagccag agcgtttcct cctcattcct tgcgtggtat      180

cagcagaagc cgggccaggc accccgcctc ctgatttact acgcatcatc tagggcaaca      240

ggtattcctg acaggttcag tggctcaggc tctggcacag attttacact cactatttcc      300

agattggagc cagaggattt tgcggtttac tattgccagc aaactgggcg aatcccaccg      360

acattcggac aaggtacgaa ggtcgaaatc aagggtggcg gagggagcgg cggtggagga      420

agcggaggcg gaggttccga ggtacagctc ttggagtctg ggggtggttt ggttcaacca      480

ggtggctctc tgcgcctgtc ctgtgcggct tctggtttta ccttctcttc attctctatg      540

tcctgggttc gacaggcacc tggaaaggga ctggagtggg tttcctctat aagcggcagt      600

tctggcacga cgtattatgc cgactccgtc aagggaaggt tcaccatttc tcgggataat      660

tcaaagaaca cactctactt gcagatgaac tcattgagag cagaagacac agcagtgtac      720

tattgtgcga agccctttcc gtatttcgat tactggggcc agggcacatt ggttactgtt      780

agcagttccg gaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg      840

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac      900

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt      960

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     1020

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1080

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     1140

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     1200

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     1260

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     1320

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     1380

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     1440

atgcaggccc tgccccctcg c                                               1461


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Sequence repeats N times, where N = an integer of at least 1.

<400>  62

Gly Ser Gly Gly Ser 
1               5   


<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  Sequence repeats N times, where N = an integer of at least 1.

<400>  63

Gly Gly Gly Ser 
1               


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Sequence repeats N times, where N = an integer of at least 1.

<400>  64

Gly Gly Gly Gly Ser 
1               5   


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  65

Gly Gly Ser Gly 
1               


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  66

Gly Gly Ser Gly Gly 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  67

Gly Ser Gly Ser Gly 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  68

Gly Ser Gly Gly Gly 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  69

Gly Gly Gly Ser Gly 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  70

Gly Ser Ser Ser Gly 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  71

Gly Gly Gly Gly Ser 
1               5   


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS Linker

<400>  72

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  73
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GS Linker Nuceotide

<400>  73
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatct                       45


<210>  74
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  74

Asp Lys Thr His Thr 
1               5   


<210>  75
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  75

Cys Pro Pro Cys 
1               


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  76

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  77

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  78

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  79

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  80

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  81

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  82
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  82

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  83
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  83

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  84
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  84

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  85
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  85

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


