                         SEQUENCE LISTING

<110>  Duke University
       Bigner, Darell
       Chandramohan, Vidya
       Pastan, Ira
 
<120>  IMMUNOTHERAPY WITH COMBINATION THERAPY COMPRISING AN IMMUNOTOXIN

<130>  155554.00570

<150>  62/927,753
<151>  2019-10-30

<150>  63/046,738
<151>  2020-07-01

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- CDR1 of VH

<400>  1

Gly Tyr Asn Met Asn 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- CDR2 of VH

<400>  2

Asn Ile Asp Pro Tyr Tyr Gly Asp Thr Asp Tyr Asp Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- CDR3 of VH

<400>  3

Gly Ala His Arg Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- CDR1 of VL

<400>  4

Arg Thr Ser Glu Asn Ile Tyr Ile Tyr Leu Ala 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- CDR2 of VL

<400>  5

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- CDR3 of VL

<400>  6

Gln Gln His Tyr Gly Thr Pro Tyr Thr 
1               5                   


<210>  7
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Truncated Pseudomonas exotoxin (PE38)

<400>  7

Gly Gly Pro Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala 
1               5                   10                  15      


Cys His Leu Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly 
            20                  25                  30          


Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala 
        35                  40                  45              


Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile 
    50                  55                  60                  


Arg Asn Ala Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala 
65                  70                  75                  80  


Ile Arg Glu Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala 
                85                  90                  95      


Ala Glu Ser Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala 
            100                 105                 110         


Gly Ala Ala Asn Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg 
        115                 120                 125             


Asn Tyr Pro Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser 
    130                 135                 140                 


Phe Ser Thr Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln 
145                 150                 155                 160 


Ala His Arg Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His 
                165                 170                 175     


Gly Thr Phe Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg 
            180                 185                 190         


Ala Arg Ser Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala 
        195                 200                 205             


Gly Asp Pro Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp 
    210                 215                 220                 


Ala Arg Gly Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro 
225                 230                 235                 240 


Arg Ser Ser Leu Pro Gly Phe Tyr Arg Thr Ser Leu Thr Leu Ala Ala 
                245                 250                 255     


Pro Glu Ala Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro 
            260                 265                 270         


Leu Arg Leu Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu 
        275                 280                 285             


Glu Thr Ile Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro 
    290                 295                 300                 


Ser Ala Ile Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro 
305                 310                 315                 320 


Ser Ser Ile Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr 
                325                 330                 335     


Ala Ser Gln Pro Gly Lys Pro Pro Arg Glu Asp Leu Lys 
            340                 345                 


<210>  8
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Cysteine rich domain 1 ("CDR1") region of CD40

<400>  8

Cys Arg Glu Lys Gln Tyr Leu Ile Asn Ser Gln Cys Cys Ser Leu Cys 
1               5                   10                  15      


Gln Pro Gly Gln Lys Leu Val Ser Asp Cys Thr Glu Phe Thr Glu Thr 
            20                  25                  30          


Glu Cys Leu Pro 
        35      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Cysteine rich domain 2 ("CDR2") region of CD40

<400>  9

Cys Gly Glu Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys 
1               5                   10                  15      


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- A1 domain of CDR1 region of CD40

<400>  10

Cys Arg Glu Lys Gln Tyr Leu Ile Asn Ser Gln Cys 
1               5                   10          


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VH

<400>  11

Glu Val His Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asp Pro Tyr Tyr Gly Asp Thr Asp Tyr Asp Gln Lys Phe Lys 
    50                  55                  60                  


Gly Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Val Tyr Met Gln Leu 
65                  70                  75                  80  


Gln Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly 
                85                  90                  95      


Ala His Arg Asp Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- VL

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Asn Ile Tyr Ile Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Gly Tyr Tyr Cys Gln Gln His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Lys Lys 
            100                 105         


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- Peptide linker

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- peptide

<400>  14

Lys Asp Glu Leu 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- peptide

<400>  15

Arg Asp Glu Leu 
1               


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- peptide

<400>  16

Lys Glu Glu Leu 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- peptide

<400>  17

Lys Asn Glu Leu 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- peptide

<400>  18

Arg Glu Glu Leu 
1               


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- peptide

<400>  19

Asp Lys Glu Leu 
1               


