                         SEQUENCE LISTING

<110>  The General Hospital Corporation
 
<120>  Gene Therapy Approaches to Mucolipidosis IV (MLIV)

<130>  29539-0404WO1

<140>  PCT/US2020/057839
<141>  2020-10-29

<150>  62/927,538
<151>  2019-10-29

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  580
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Mucolipin-1

<400>  1

Met Thr Ala Pro Ala Gly Pro Arg Gly Ser Glu Thr Glu Arg Leu Leu 
1               5                   10                  15      


Thr Pro Asn Pro Gly Tyr Gly Thr Gln Ala Gly Pro Ser Pro Ala Pro 
            20                  25                  30          


Pro Thr Pro Pro Glu Glu Glu Asp Leu Arg Arg Arg Leu Lys Tyr Phe 
        35                  40                  45              


Phe Met Ser Pro Cys Asp Lys Phe Arg Ala Lys Gly Arg Lys Pro Cys 
    50                  55                  60                  


Lys Leu Met Leu Gln Val Val Lys Ile Leu Val Val Thr Val Gln Leu 
65                  70                  75                  80  


Ile Leu Phe Gly Leu Ser Asn Gln Leu Ala Val Thr Phe Arg Glu Glu 
                85                  90                  95      


Asn Thr Ile Ala Phe Arg His Leu Phe Leu Leu Gly Tyr Ser Asp Gly 
            100                 105                 110         


Ala Asp Asp Thr Phe Ala Ala Tyr Thr Arg Glu Gln Leu Tyr Gln Ala 
        115                 120                 125             


Ile Phe His Ala Val Asp Gln Tyr Leu Ala Leu Pro Asp Val Ser Leu 
    130                 135                 140                 


Gly Arg Tyr Ala Tyr Val Arg Gly Gly Gly Asp Pro Trp Thr Asn Gly 
145                 150                 155                 160 


Ser Gly Leu Ala Leu Cys Gln Arg Tyr Tyr His Arg Gly His Val Asp 
                165                 170                 175     


Pro Ala Asn Asp Thr Phe Asp Ile Asp Pro Met Val Val Thr Asp Cys 
            180                 185                 190         


Ile Gln Val Asp Pro Pro Glu Arg Pro Pro Pro Pro Pro Ser Asp Asp 
        195                 200                 205             


Leu Thr Leu Leu Glu Ser Ser Ser Ser Tyr Lys Asn Leu Thr Leu Lys 
    210                 215                 220                 


Phe His Lys Leu Val Asn Val Thr Ile His Phe Arg Leu Lys Thr Ile 
225                 230                 235                 240 


Asn Leu Gln Ser Leu Ile Asn Asn Glu Ile Pro Asp Cys Tyr Thr Phe 
                245                 250                 255     


Ser Val Leu Ile Thr Phe Asp Asn Lys Ala His Ser Gly Arg Ile Pro 
            260                 265                 270         


Ile Ser Leu Glu Thr Gln Ala His Ile Gln Glu Cys Lys His Pro Ser 
        275                 280                 285             


Val Phe Gln His Gly Asp Asn Ser Phe Arg Leu Leu Phe Asp Val Val 
    290                 295                 300                 


Val Ile Leu Thr Cys Ser Leu Ser Phe Leu Leu Cys Ala Arg Ser Leu 
305                 310                 315                 320 


Leu Arg Gly Phe Leu Leu Gln Asn Glu Phe Val Gly Phe Met Trp Arg 
                325                 330                 335     


Gln Arg Gly Arg Val Ile Ser Leu Trp Glu Arg Leu Glu Phe Val Asn 
            340                 345                 350         


Gly Trp Tyr Ile Leu Leu Val Thr Ser Asp Val Leu Thr Ile Ser Gly 
        355                 360                 365             


Thr Ile Met Lys Ile Gly Ile Glu Ala Lys Asn Leu Ala Ser Tyr Asp 
    370                 375                 380                 


Val Cys Ser Ile Leu Leu Gly Thr Ser Thr Leu Leu Val Trp Val Gly 
385                 390                 395                 400 


Val Ile Arg Tyr Leu Thr Phe Phe His Asn Tyr Asn Ile Leu Ile Ala 
                405                 410                 415     


Thr Leu Arg Val Ala Leu Pro Ser Val Met Arg Phe Cys Cys Cys Val 
            420                 425                 430         


Ala Val Ile Tyr Leu Gly Tyr Cys Phe Cys Gly Trp Ile Val Leu Gly 
        435                 440                 445             


Pro Tyr His Val Lys Phe Arg Ser Leu Ser Met Val Ser Glu Cys Leu 
    450                 455                 460                 


Phe Ser Leu Ile Asn Gly Asp Asp Met Phe Val Thr Phe Ala Ala Met 
465                 470                 475                 480 


Gln Ala Gln Gln Gly Arg Ser Ser Leu Val Trp Leu Phe Ser Gln Leu 
                485                 490                 495     


Tyr Leu Tyr Ser Phe Ile Ser Leu Phe Ile Tyr Met Val Leu Ser Leu 
            500                 505                 510         


Phe Ile Ala Leu Ile Thr Gly Ala Tyr Asp Thr Ile Lys His Pro Gly 
        515                 520                 525             


Gly Ala Gly Ala Glu Glu Ser Glu Leu Gln Ala Tyr Ile Ala Gln Cys 
    530                 535                 540                 


Gln Asp Ser Pro Thr Ser Gly Lys Phe Arg Arg Gly Ser Gly Ser Ala 
545                 550                 555                 560 


Cys Ser Leu Leu Cys Cys Cys Gly Arg Asp Pro Ser Glu Glu His Ser 
                565                 570                 575     


Leu Leu Val Asn 
            580 


<210>  2
<211>  2084
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  mucolipin 1 (MCOLN1)

<400>  2
acagatcagc tgatgccgga gggtttgaag ccgcgccgcg agggagcgag gtcgcagtga       60

cagcggcggg cgatcggacc caggctgccc cgccgtaccc gcctgcgtcc cgcgctcccg      120

ccccagcatg acagccccgg cgggtccgcg cggctcagag accgagcggc ttctgacccc      180

caaccccggg tatgggaccc aggcggggcc ttcaccggcc cctccgacac ccccagaaga      240

ggaagacctt cgccgtcgtc tcaaatactt tttcatgagt ccctgcgaca agtttcgagc      300

caagggccgc aagccctgca agctgatgct gcaagtggtc aagatcctgg tggtcacggt      360

gcagctcatc ctgtttgggc tcagtaatca gctggctgtg acattccggg aagagaacac      420

catcgccttc cgacacctct tcctgctggg ctactcggac ggagcggatg acaccttcgc      480

agcctacacg cgggagcagc tgtaccaggc catcttccat gctgtggacc agtacctggc      540

gttgcctgac gtgtcactgg gccggtatgc gtatgtccgt ggtgggggtg acccttggac      600

caatggctca gggcttgctc tctgccagcg gtactaccac cgaggccacg tggacccggc      660

caacgacaca tttgacattg atccgatggt ggttactgac tgcatccagg tggatccccc      720

cgagcggccc cctccgcccc ccagcgacga tctcaccctc ttggaaagca gctccagtta      780

caagaacctc acgctcaaat tccacaagct ggtcaatgtc accatccact tccggctgaa      840

gaccattaac ctccagagcc tcatcaataa tgagatcccg gactgctata ccttcagcgt      900

cctgatcacg tttgacaaca aagcacacag tgggcggatc cccatcagcc tggagaccca      960

ggcccacatc caggagtgta agcaccccag tgtcttccag cacggagaca acagcttccg     1020

gctcctgttt gacgtggtgg tcatcctcac ctgctccctg tccttcctcc tctgcgcccg     1080

ctcactcctt cgaggcttcc tgctgcagaa cgagtttgtg gggttcatgt ggcggcagcg     1140

gggacgggtc atcagcctgt gggagcggct ggaatttgtc aatggctggt acatcctgct     1200

cgtcaccagc gatgtgctca ccatctcggg caccatcatg aagatcggca tcgaggccaa     1260

gaacttggcg agctacgacg tctgcagcat cctcctgggc acctcgacgc tgctggtgtg     1320

ggtgggcgtg atccgctacc tgaccttctt ccacaactac aatatcctca tcgccacact     1380

gcgggtggcc ctgcccagcg tcatgcgctt ctgctgctgc gtggctgtca tctacctggg     1440

ctactgcttc tgtggctgga tcgtgctggg gccctatcat gtgaagttcc gctcactctc     1500

catggtgtct gagtgcctgt tctcgctcat caatggggac gacatgtttg tgacgttcgc     1560

cgccatgcag gcgcagcagg gccgcagcag cctggtgtgg ctcttctccc agctctacct     1620

ttactccttc atcagcctct tcatctacat ggtgctcagc ctcttcatcg cgctcatcac     1680

cggcgcctac gacaccatca agcatcccgg cggcgcaggc gcagaggaga gcgagctgca     1740

ggcctacatc gcacagtgcc aggacagccc cacctccggc aagttccgcc gcgggagcgg     1800

ctcggcctgc agccttctct gctgctgcgg aagggacccc tcggaggagc attcgctgct     1860

ggtgaattga ttcgacctga ctgccgttgg accgtaggcc ctggactgca gagacccccg     1920

cccccgaccc cgcttattta tttgtagggt ttgcttttaa ggatcggctc cctgtcgcgc     1980

ccgaggaggg cctggacctt tcgtgtcgga cccttggggg cggggagact gggtggggag     2040

ggtgttgaat aaaagggaaa ataaatgtgt cgttttcatt ttta                      2084


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2A consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


<210>  4
<211>  5158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  >pAAV SC.JeT.Mcoln.pA  (5158 bp)

<400>  4
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggttaa gctagcgaat      120

tcgggcggag ttagggcgga gccaatcagc gtgcgccgtt ccgaaagttg ccttttatgg      180

ctgggcggag aatgggcggt gaacgccgat gattatataa ggacgcgccg ggtgtggcac      240

agctagttcc gtcgcagccg ggatttgggt cgcggttctt gtttgtggat ccctgtgatc      300

gtcacttgac agtgtccagg cggccgccac catgacagcc ccggcgggtc cgcgcggctc      360

agagaccgag cggcttctga cccccaaccc cgggtatggg acccaggcgg ggccttcacc      420

ggcccctccg acacccccag aagaggaaga ccttcgccgt cgtctcaaat actttttcat      480

gagtccctgc gacaagtttc gagccaaggg ccgcaagccc tgcaagctga tgctgcaagt      540

ggtcaagatc ctggtggtca cggtgcagct catcctgttt gggctcagta atcagctggc      600

tgtgacattc cgggaagaga acaccatcgc cttccgacac ctcttcctgc tgggctactc      660

ggacggagcg gatgacacct tcgcagccta cacgcgggag cagctgtacc aggccatctt      720

ccatgctgtg gaccagtacc tggcgttgcc tgacgtgtca ctgggccggt atgcgtatgt      780

ccgtggtggg ggtgaccctt ggaccaatgg ctcagggctt gctctctgcc agcggtacta      840

ccaccgaggc cacgtggacc cggccaacga cacatttgac attgatccga tggtggttac      900

tgactgcatc caggtggatc cccccgagcg gccccctccg ccccccagcg acgatctcac      960

cctcttggaa agcagctcca gttacaagaa cctcacgctc aaattccaca agctggtcaa     1020

tgtcaccatc cacttccggc tgaagaccat taacctccag agcctcatca ataatgagat     1080

cccggactgc tataccttca gcgtcctgat cacgtttgac aacaaagcac acagtgggcg     1140

gatccccatc agcctggaga cccaggccca catccaggag tgtaagcacc ccagtgtctt     1200

ccagcacgga gacaacagct tccggctcct gtttgacgtg gtggtcatcc tcacctgctc     1260

cctgtccttc ctcctctgcg cccgctcact ccttcgaggc ttcctgctgc agaacgagtt     1320

tgtggggttc atgtggcggc agcggggacg ggtcatcagc ctgtgggagc ggctggaatt     1380

tgtcaatggc tggtacatcc tgctcgtcac cagcgatgtg ctcaccatct cgggcaccat     1440

catgaagatc ggcatcgagg ccaagaactt ggcgagctac gacgtctgca gcatcctcct     1500

gggcacctcg acgctgctgg tgtgggtggg cgtgatccgc tacctgacct tcttccacaa     1560

ctacaatatc ctcatcgcca cactgcgggt ggccctgccc agcgtcatgc gcttctgctg     1620

ctgcgtggct gtcatctacc tgggctactg cttctgtggc tggatcgtgc tggggcccta     1680

tcatgtgaag ttccgctcac tctccatggt gtctgagtgc ctgttctcgc tcatcaatgg     1740

ggacgacatg tttgtgacgt tcgccgccat gcaggcgcag cagggccgca gcagcctggt     1800

gtggctcttc tcccagctct acctttactc cttcatcagc ctcttcatct acatggtgct     1860

cagcctcttc atcgcgctca tcaccggcgc ctacgacacc atcaagcatc ccggcggcgc     1920

aggcgcagag gagagcgagc tgcaggccta catcgcacag tgccaggaca gccccacctc     1980

cggcaagttc cgccgcggga gcggctcggc ctgcagcctt ctctgctgct gcggaaggga     2040

cccctcggag gagcattcgc tgctggtgaa ttaataagct taataaaaga tctttatttt     2100

cattagatct gtgtgttggt tttttgtgtg ctcgagttaa gggcgaattc ccgataagga     2160

tcttcctaga gcatggctac gtagataagt agcatggcgg gttaatcatt aactacaagg     2220

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     2280

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     2340

cgcgcagcct taattaacct aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa     2400

accctggcgt tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta     2460

atagcgaaga ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat     2520

gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga     2580

ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct tcctttctcg     2640

ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta gggttccgat     2700

ttagtgcttt acggcacctc gaccccaaaa aacttgatta gggtgatggt tcacgtagtg     2760

ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg ttctttaata     2820

gtggactctt gttccaaact ggaacaacac tcaaccctat ctcggtctat tcttttgatt     2880

tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat     2940

ttaacgcgaa ttttaacaaa atattaacgt ttataatttc aggtggcatc tttcggggaa     3000

atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca     3060

tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc     3120

aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc     3180

acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt     3240

acatcgaact ggatctcaat agtggtaaga tccttgagag ttttcgcccc gaagaacgtt     3300

ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg     3360

ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact     3420

caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg     3480

ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga     3540

aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg     3600

aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagtaa     3660

tggtaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac     3720

aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc     3780

cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca     3840

ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga     3900

gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta     3960

agcattggta actgtcagac caagtttact catatatact ttagattgat ttaaaacttc     4020

atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc     4080

cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt     4140

cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac     4200

cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct     4260

tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact     4320

tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg     4380

ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata     4440

aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga     4500

cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag     4560

ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg     4620

agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac     4680

ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca     4740

acgcggcctt tttacggttc ctggcctttt gctgcggttt tgctcacatg ttctttcctg     4800

cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc     4860

gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa     4920

tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt     4980

ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt     5040

aggcacccca ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg     5100

gataacaatt tcacacagga aacagctatg accatgatta cgccagattt aattaagg       5158


<210>  5
<211>  5411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  >pAAV SC.hSyn1.Mcoln.pA  (5411 bp)

<400>  5
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggttaa gctagcagtg      120

caagtgggtt ttaggaccag gatgaggcgg ggtgggggtg cctacctgac gaccgacccc      180

gacccactgg acaagcaccc aacccccatt ccccaaattg cgcatcccct atcagagagg      240

gggaggggaa acaggatgcg gcgaggcgcg tgcgcactgc cagcttcagc accgcggaca      300

gtgccttcgc ccccgcctgg cggcgcgcgc caccgccgcc tcagcactga aggcgcgctg      360

acgtcactcg ccggtccccc gcaaactccc cttcccggcc accttggtcg cgtccgcgcc      420

gccgccggcc cagccggacc gcaccacgcg aggcgcgaga taggggggca cgggcgcgac      480

catctgcgct gcggcgccgg cgactcagcg ctgcctcagt ctgcggtggg cagcggagga      540

gtcgtgtcgt gcctgagagc gcaggtgtcc aggcggccgc caccatgaca gccccggcgg      600

gtccgcgcgg ctcagagacc gagcggcttc tgacccccaa ccccgggtat gggacccagg      660

cggggccttc accggcccct ccgacacccc cagaagagga agaccttcgc cgtcgtctca      720

aatacttttt catgagtccc tgcgacaagt ttcgagccaa gggccgcaag ccctgcaagc      780

tgatgctgca agtggtcaag atcctggtgg tcacggtgca gctcatcctg tttgggctca      840

gtaatcagct ggctgtgaca ttccgggaag agaacaccat cgccttccga cacctcttcc      900

tgctgggcta ctcggacgga gcggatgaca ccttcgcagc ctacacgcgg gagcagctgt      960

accaggccat cttccatgct gtggaccagt acctggcgtt gcctgacgtg tcactgggcc     1020

ggtatgcgta tgtccgtggt gggggtgacc cttggaccaa tggctcaggg cttgctctct     1080

gccagcggta ctaccaccga ggccacgtgg acccggccaa cgacacattt gacattgatc     1140

cgatggtggt tactgactgc atccaggtgg atccccccga gcggccccct ccgcccccca     1200

gcgacgatct caccctcttg gaaagcagct ccagttacaa gaacctcacg ctcaaattcc     1260

acaagctggt caatgtcacc atccacttcc ggctgaagac cattaacctc cagagcctca     1320

tcaataatga gatcccggac tgctatacct tcagcgtcct gatcacgttt gacaacaaag     1380

cacacagtgg gcggatcccc atcagcctgg agacccaggc ccacatccag gagtgtaagc     1440

accccagtgt cttccagcac ggagacaaca gcttccggct cctgtttgac gtggtggtca     1500

tcctcacctg ctccctgtcc ttcctcctct gcgcccgctc actccttcga ggcttcctgc     1560

tgcagaacga gtttgtgggg ttcatgtggc ggcagcgggg acgggtcatc agcctgtggg     1620

agcggctgga atttgtcaat ggctggtaca tcctgctcgt caccagcgat gtgctcacca     1680

tctcgggcac catcatgaag atcggcatcg aggccaagaa cttggcgagc tacgacgtct     1740

gcagcatcct cctgggcacc tcgacgctgc tggtgtgggt gggcgtgatc cgctacctga     1800

ccttcttcca caactacaat atcctcatcg ccacactgcg ggtggccctg cccagcgtca     1860

tgcgcttctg ctgctgcgtg gctgtcatct acctgggcta ctgcttctgt ggctggatcg     1920

tgctggggcc ctatcatgtg aagttccgct cactctccat ggtgtctgag tgcctgttct     1980

cgctcatcaa tggggacgac atgtttgtga cgttcgccgc catgcaggcg cagcagggcc     2040

gcagcagcct ggtgtggctc ttctcccagc tctaccttta ctccttcatc agcctcttca     2100

tctacatggt gctcagcctc ttcatcgcgc tcatcaccgg cgcctacgac accatcaagc     2160

atcccggcgg cgcaggcgca gaggagagcg agctgcaggc ctacatcgca cagtgccagg     2220

acagccccac ctccggcaag ttccgccgcg ggagcggctc ggcctgcagc cttctctgct     2280

gctgcggaag ggacccctcg gaggagcatt cgctgctggt gaattaataa gcttaataaa     2340

agatctttat tttcattaga tctgtgtgtt ggttttttgt gtgctcgagt taagggcgaa     2400

ttcccgataa ggatcttcct agagcatggc tacgtagata agtagcatgg cgggttaatc     2460

attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     2520

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     2580

gtgagcgagc gagcgcgcag ccttaattaa cctaattcac tggccgtcgt tttacaacgt     2640

cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc     2700

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     2760

ctgaatggcg aatgggacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     2820

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     2880

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     2940

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     3000

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     3060

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     3120

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     3180

atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttataat ttcaggtggc     3240

atctttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     3300

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag     3360

agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt     3420

cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt     3480

gcacgagtgg gttacatcga actggatctc aatagtggta agatccttga gagttttcgc     3540

cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta     3600

tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac     3660

ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa     3720

ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg     3780

atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc     3840

cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg     3900

atgcctgtag taatggtaac aacgttgcgc aaactattaa ctggcgaact acttactcta     3960

gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg     4020

cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg     4080

tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc     4140

tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt     4200

gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt     4260

gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     4320

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     4380

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     4440

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     4500

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     4560

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     4620

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     4680

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     4740

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     4800

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     4860

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     4920

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     4980

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctgcgg ttttgctcac     5040

atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga     5100

gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg     5160

gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatgcagc     5220

tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt     5280

tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg tatgttgtgt     5340

ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga ttacgccaga     5400

tttaattaag g                                                          5411


