                         SEQUENCE LISTING

<110>  LBL BIOTECHNOLOGY INC.
 
<120>  TREATING TISSUE FIBROSIS AND/OR INJURY AND/OR ORGAN FAILURE WITH 
       INTERLEUKIN 24 OR INTERLEUKIN 20 ANTAGONIST

<130>  none

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  363
<212>  DNA
<213>  mouse


<220>
<221>  CDS
<222>  (1)..(363)

<400>  1
gaa ttg aag ctt gag gag tct gga gga ggc ttg gtg cag cct gga gga         48
Glu Leu Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc atg aaa ctc tct tgt gct gcc tct gga ttc act ttt agt gac gcc         96
Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala           
            20                  25                  30                    

tgg atg gac tgg gtc cgc cag tct cca gag aag ggg ctt gag tgg att        144
Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

gct gaa att aga agc aaa gct aat aat tat gca aca tac ttt gct gag        192
Ala Glu Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr Phe Ala Glu           
    50                  55                  60                            

tct gtg aaa ggg agg ttc acc atc tca aga gat gat tcc aaa agt ggt        240
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Gly           
65                  70                  75                  80            

gtc tac ctg caa atg aac aac tta aga gct gag gac act ggc att tat        288
Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr           
                85                  90                  95                

ttc tgt acc aag tta tca cta cgt tac tgg ttc ttc gat gtc tgg ggc        336
Phe Cys Thr Lys Leu Ser Leu Arg Tyr Trp Phe Phe Asp Val Trp Gly           
            100                 105                 110                   

gca ggg acc acg gtc acc gtc tcc tca                                    363
Ala Gly Thr Thr Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  2
<211>  121
<212>  PRT
<213>  mouse

<400>  2

Glu Leu Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr Phe Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Gly 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Phe Cys Thr Lys Leu Ser Leu Arg Tyr Trp Phe Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  339
<212>  DNA
<213>  mouse


<220>
<221>  CDS
<222>  (1)..(339)

<400>  3
gat ttt gtg atg acc cag act cca ctc act ttg tcg gtt acc att gga         48
Asp Phe Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly           
1               5                   10                  15                

caa cca gcc tcc atc tct tgc aag tca agt cag agc ctc ttg gat agt         96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser           
            20                  25                  30                    

gat gga aag aca tat ttg aat tgg ttg tta cag agg cca ggc cag tct        144
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser           
        35                  40                  45                        

cca aag cac ctc atc tat ctg gtg tct aaa ctg gac tct gga gtc cct        192
Pro Lys His Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc act ggc agt gga tca ggg acc gat ttc aca ctg aga atc        240
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat ttg gga gtt tat tat tgc tgg caa agt        288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Ser           
                85                  90                  95                

aca cat ttt ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa        336
Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   

cgg                                                                    339
Arg                                                                       
                                                                          


<210>  4
<211>  113
<212>  PRT
<213>  mouse

<400>  4

Asp Phe Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys His Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Ser 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  5
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized antibody


<220>
<221>  CDS
<222>  (1)..(420)

<400>  5
atg tac ttg gga ctg aac tat gtt ttc atc gtt ttt ctc ctg aat ggt         48
Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly           
1               5                   10                  15                

gtc cag agt gaa gtg cag ctt gtg gag tct gga gga ggc ttg gtg cag         96
Val Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln           
            20                  25                  30                    

cct gga gga tcc ctg aaa ctc tct tgt gct gcc tct gga ttc act ttt        144
Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe           
        35                  40                  45                        

agt gac gcc tgg atg gac tgg gtc cgc cag gct tcc ggg aag ggg ctt        192
Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ala Ser Gly Lys Gly Leu           
    50                  55                  60                            

gag tgg att gct gaa att aga agc aaa gct aat aat tat gca aca tac        240
Glu Trp Ile Ala Glu Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr           
65                  70                  75                  80            

ttt gct gag tct gtg aaa ggg agg ttc acc atc tca aga gat gat tcc        288
Phe Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser           
                85                  90                  95                

aaa aac acc gcc tac ctg caa atg aac agc tta aaa acc gag gac act        336
Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr           
            100                 105                 110                   

gcc gtt tat tac tgt acc aag tta tca ctg cgt tac tgg ttc ttc gat        384
Ala Val Tyr Tyr Cys Thr Lys Leu Ser Leu Arg Tyr Trp Phe Phe Asp           
        115                 120                 125                       

gtc tgg ggc cag ggg acc ctg gtc acc gtc tcc tca                        420
Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser                           
    130                 135                 140                           


<210>  6
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Tyr Leu Gly Leu Asn Tyr Val Phe Ile Val Phe Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Ala Trp Met Asp Trp Val Arg Gln Ala Ser Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ala Glu Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr 
65                  70                  75                  80  


Phe Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Lys Leu Ser Leu Arg Tyr Trp Phe Phe Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140 


<210>  7
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized antibody


<220>
<221>  CDS
<222>  (1)..(363)

<400>  7
gaa gtg cag ctt gtg gag tct gga gga ggc ttg gtg cag cct gga gga         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tcc ctg aaa ctc tct tgt gct gcc tct gga ttc act ttt agt gac gcc         96
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala           
            20                  25                  30                    

tgg atg gac tgg gtc cgc cag gct tcc ggg aag ggg ctt gag tgg att        144
Trp Met Asp Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

gct gaa att aga agc aaa gct aat aat tat gca aca tac ttt gct gag        192
Ala Glu Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr Phe Ala Glu           
    50                  55                  60                            

tct gtg aaa ggg agg ttc acc atc tca aga gat gat tcc aaa aac acc        240
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr           
65                  70                  75                  80            

gcc tac ctg caa atg aac agc tta aaa acc gag gac act gcc gtt tat        288
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr           
                85                  90                  95                

tac tgt acc aag tta tca ctg cgt tac tgg ttc ttc gat gtc tgg ggc        336
Tyr Cys Thr Lys Leu Ser Leu Arg Tyr Trp Phe Phe Asp Val Trp Gly           
            100                 105                 110                   

cag ggg acc ctg gtc acc gtc tcc tca                                    363
Gln Gly Thr Leu Val Thr Val Ser Ser                                       
        115                 120                                           


<210>  8
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr Phe Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Lys Leu Ser Leu Arg Tyr Trp Phe Phe Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  9
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized antibody


<220>
<221>  CDS
<222>  (1)..(396)

<400>  9
atg atg agt cct gcc cag ttc ctg ttt ctg ttg gtg ctc tgg att cgg         48
Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg           
1               5                   10                  15                

gaa acc aac ggt gat atc gtg atg acc cag act cca ctc tct ttg tcc         96
Glu Thr Asn Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser           
            20                  25                  30                    

gtt acc cct gga caa cca gcc tcc atc tct tgc aag tca agt cag agc        144
Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser           
        35                  40                  45                        

ctc ttg gat agt gat gga aag aca tat ttg aat tgg ttg tta cag aag        192
Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Lys           
    50                  55                  60                            

cca ggc cag tct cca cag cac ctc atc tat ctg gtg tct aaa ctg gac        240
Pro Gly Gln Ser Pro Gln His Leu Ile Tyr Leu Val Ser Lys Leu Asp           
65                  70                  75                  80            

tct gga gtc cct gac agg ttc agt ggc agt gga tca ggg acc gat ttc        288
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe           
                85                  90                  95                

aca ctg aaa atc agc aga gtg gag gct gag gat gtt gga gtt tat tat        336
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr           
            100                 105                 110                   

tgc tgg caa agt aca cat ttt ccc tgg acc ttc ggt gga ggc acc aag        384
Cys Trp Gln Ser Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys           
        115                 120                 125                       

gtg gaa atc aaa                                                        396
Val Glu Ile Lys                                                           
    130                                                                   


<210>  10
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg 
1               5                   10                  15      


Glu Thr Asn Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser 
            20                  25                  30          


Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln His Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Trp Gln Ser Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys 
    130         


<210>  11
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized antibody


<220>
<221>  CDS
<222>  (1)..(336)

<400>  11
gat atc gtg atg acc cag act cca ctc tct ttg tcc gtt acc cct gga         48
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly           
1               5                   10                  15                

caa cca gcc tcc atc tct tgc aag tca agt cag agc ctc ttg gat agt         96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser           
            20                  25                  30                    

gat gga aag aca tat ttg aat tgg ttg tta cag aag cca ggc cag tct        144
Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca cag cac ctc atc tat ctg gtg tct aaa ctg gac tct gga gtc cct        192
Pro Gln His Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggc agt gga tca ggg acc gat ttc aca ctg aaa atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat gtt gga gtt tat tat tgc tgg caa agt        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Ser           
                85                  90                  95                

aca cat ttt ccc tgg acc ttc ggt gga ggc acc aag gtg gaa atc aaa        336
Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln His Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Ser 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody

<400>  13

Asp Phe Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln His Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Trp Gln Ser 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


