                         SEQUENCE LISTING

<110>  Yeda Research And Development Co. Ltd.
       SHLUSH, Liran
       FELDMAN, Tzah
 
<120>  PREVENTION AND TREATMENT OF PRE-MYELOID AND MYELOID MALIGNANCIES

<130>  84567

<150>  IL 270306
<151>  2019-10-30

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  1014
<212>  PRT
<213>  homo sapiens

<400>  1

Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser 
1               5                   10                  15      


Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser 
            20                  25                  30          


Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val 
        35                  40                  45              


Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile 
    50                  55                  60                  


Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp 
65                  70                  75                  80  


Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly 
                85                  90                  95      


Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp 
            100                 105                 110         


Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys 
        115                 120                 125             


Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val 
    130                 135                 140                 


Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro 
145                 150                 155                 160 


Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr 
                165                 170                 175     


Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys 
            180                 185                 190         


Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg 
        195                 200                 205             


Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser 
    210                 215                 220                 


Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala 
225                 230                 235                 240 


Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys 
                245                 250                 255     


Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val 
            260                 265                 270         


Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val 
        275                 280                 285             


Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe 
    290                 295                 300                 


Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys 
305                 310                 315                 320 


Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro 
                325                 330                 335     


Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys 
            340                 345                 350         


Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr 
        355                 360                 365             


Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala 
    370                 375                 380                 


Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys 
385                 390                 395                 400 


Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly 
                405                 410                 415     


Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr 
            420                 425                 430         


Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu 
        435                 440                 445             


Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala 
    450                 455                 460                 


Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro 
465                 470                 475                 480 


Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg 
                485                 490                 495     


Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys 
            500                 505                 510         


Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys 
        515                 520                 525             


Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His 
    530                 535                 540                 


Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val 
545                 550                 555                 560 


Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu 
                565                 570                 575     


Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val 
            580                 585                 590         


Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu 
        595                 600                 605             


Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn 
    610                 615                 620                 


Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro 
625                 630                 635                 640 


Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr 
                645                 650                 655     


Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu 
            660                 665                 670         


Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu 
        675                 680                 685             


Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg 
    690                 695                 700                 


Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val 
705                 710                 715                 720 


Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe 
                725                 730                 735     


Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu 
            740                 745                 750         


Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu 
        755                 760                 765             


Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp 
    770                 775                 780                 


Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp 
785                 790                 795                 800 


Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys 
                805                 810                 815     


Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu 
            820                 825                 830         


Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr 
        835                 840                 845             


Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser 
    850                 855                 860                 


Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala 
865                 870                 875                 880 


Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr 
                885                 890                 895     


Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln 
            900                 905                 910         


Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn 
        915                 920                 925             


Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly 
    930                 935                 940                 


Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala 
945                 950                 955                 960 


Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser 
                965                 970                 975     


Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr 
            980                 985                 990         


Asp Ile Ala Gln Val Asn Leu Lys  Tyr Leu Leu Lys Leu  Lys Phe Asn 
        995                 1000                 1005             


Phe Lys  Thr Ser Leu Trp 
    1010                 


<210>  2
<211>  897
<212>  PRT
<213>  homo sapiens

<400>  2

Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp 
            20                  25                  30          


Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu 
        35                  40                  45              


Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln 
    50                  55                  60                  


Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu 
65                  70                  75                  80  


Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu 
                85                  90                  95      


Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln 
            100                 105                 110         


Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln 
        115                 120                 125             


Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn 
    130                 135                 140                 


Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile 
145                 150                 155                 160 


Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu 
                165                 170                 175     


Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr 
            180                 185                 190         


Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys 
        195                 200                 205             


Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val 
    210                 215                 220                 


Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly 
225                 230                 235                 240 


Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val 
                245                 250                 255     


Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln 
            260                 265                 270         


Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly 
        275                 280                 285             


Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp 
    290                 295                 300                 


Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu 
305                 310                 315                 320 


Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile 
                325                 330                 335     


Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln 
            340                 345                 350         


Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys 
        355                 360                 365             


Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu 
    370                 375                 380                 


Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln 
385                 390                 395                 400 


Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu 
                405                 410                 415     


Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys 
            420                 425                 430         


His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys 
        435                 440                 445             


Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser 
    450                 455                 460                 


Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser 
465                 470                 475                 480 


Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg 
                485                 490                 495     


Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser 
            500                 505                 510         


Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile 
        515                 520                 525             


Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr 
    530                 535                 540                 


Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile 
545                 550                 555                 560 


Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln 
                565                 570                 575     


Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu 
            580                 585                 590         


Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser 
        595                 600                 605             


His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu 
    610                 615                 620                 


Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys 
625                 630                 635                 640 


Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser 
                645                 650                 655     


Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val 
            660                 665                 670         


Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val 
        675                 680                 685             


Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys 
    690                 695                 700                 


Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met 
705                 710                 715                 720 


Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr 
                725                 730                 735     


Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu 
            740                 745                 750         


Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln 
        755                 760                 765             


Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp 
    770                 775                 780                 


Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg 
785                 790                 795                 800 


Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys 
                805                 810                 815     


Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu 
            820                 825                 830         


Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Thr Pro 
        835                 840                 845             


Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu 
    850                 855                 860                 


Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg 
865                 870                 875                 880 


Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys 
                885                 890                 895     


Thr 
    


<210>  3
<211>  867
<212>  PRT
<213>  homo sapiens

<400>  3

Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp 
            20                  25                  30          


Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu 
        35                  40                  45              


Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln 
    50                  55                  60                  


Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu 
65                  70                  75                  80  


Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu 
                85                  90                  95      


Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln 
            100                 105                 110         


Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln 
        115                 120                 125             


Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn 
    130                 135                 140                 


Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile 
145                 150                 155                 160 


Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu 
                165                 170                 175     


Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr 
            180                 185                 190         


Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys 
        195                 200                 205             


Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val 
    210                 215                 220                 


Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly 
225                 230                 235                 240 


Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val 
                245                 250                 255     


Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln 
            260                 265                 270         


Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly 
        275                 280                 285             


Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp 
    290                 295                 300                 


Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu 
305                 310                 315                 320 


Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile 
                325                 330                 335     


Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln 
            340                 345                 350         


Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys 
        355                 360                 365             


Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu 
    370                 375                 380                 


Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln 
385                 390                 395                 400 


Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu 
                405                 410                 415     


Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys 
            420                 425                 430         


His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys 
        435                 440                 445             


Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser 
    450                 455                 460                 


Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser 
465                 470                 475                 480 


Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg 
                485                 490                 495     


Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser 
            500                 505                 510         


Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile 
        515                 520                 525             


Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr 
    530                 535                 540                 


Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile 
545                 550                 555                 560 


Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln 
                565                 570                 575     


Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu 
            580                 585                 590         


Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser 
        595                 600                 605             


His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu 
    610                 615                 620                 


Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys 
625                 630                 635                 640 


Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser 
                645                 650                 655     


Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val 
            660                 665                 670         


Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val 
        675                 680                 685             


Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys 
    690                 695                 700                 


Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met 
705                 710                 715                 720 


Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr 
                725                 730                 735     


Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu 
            740                 745                 750         


Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln 
        755                 760                 765             


Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp 
    770                 775                 780                 


Glu Ser Ile Met Gln Ile Cys Gln Gln Lys Lys Glu Lys Arg Asn Trp 
785                 790                 795                 800 


Leu Pro Ala Gln Asp Thr Asp Ser Ala Thr Phe His Pro Thr His Gln 
                805                 810                 815     


Arg Ile Phe Gly Lys Leu Val Phe Leu Pro Leu Arg Leu Val Trp Lys 
            820                 825                 830         


Glu Val Ile Leu Arg Lys Ile Leu Ile Leu Val Leu Val Gln Lys Asp 
        835                 840                 845             


Val Ser Leu Thr Thr Gln Tyr Phe Leu Gln Lys Ala Arg Ser Arg Arg 
    850                 855                 860                 


His Arg Arg 
865         


<210>  4
<211>  897
<212>  PRT
<213>  homo sapiens

<400>  4

Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp 
            20                  25                  30          


Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu 
        35                  40                  45              


Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln 
    50                  55                  60                  


Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu 
65                  70                  75                  80  


Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu 
                85                  90                  95      


Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln 
            100                 105                 110         


Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln 
        115                 120                 125             


Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn 
    130                 135                 140                 


Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile 
145                 150                 155                 160 


Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu 
                165                 170                 175     


Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr 
            180                 185                 190         


Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys 
        195                 200                 205             


Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val 
    210                 215                 220                 


Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly 
225                 230                 235                 240 


Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val 
                245                 250                 255     


Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln 
            260                 265                 270         


Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly 
        275                 280                 285             


Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp 
    290                 295                 300                 


Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu 
305                 310                 315                 320 


Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile 
                325                 330                 335     


Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln 
            340                 345                 350         


Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys 
        355                 360                 365             


Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu 
    370                 375                 380                 


Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln 
385                 390                 395                 400 


Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu 
                405                 410                 415     


Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys 
            420                 425                 430         


His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys 
        435                 440                 445             


Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser 
    450                 455                 460                 


Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser 
465                 470                 475                 480 


Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg 
                485                 490                 495     


Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser 
            500                 505                 510         


Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile 
        515                 520                 525             


Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr 
    530                 535                 540                 


Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile 
545                 550                 555                 560 


Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln 
                565                 570                 575     


Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu 
            580                 585                 590         


Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser 
        595                 600                 605             


His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu 
    610                 615                 620                 


Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys 
625                 630                 635                 640 


Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser 
                645                 650                 655     


Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val 
            660                 665                 670         


Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val 
        675                 680                 685             


Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys 
    690                 695                 700                 


Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met 
705                 710                 715                 720 


Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr 
                725                 730                 735     


Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu 
            740                 745                 750         


Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln 
        755                 760                 765             


Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp 
    770                 775                 780                 


Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg 
785                 790                 795                 800 


Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys 
                805                 810                 815     


Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu 
            820                 825                 830         


Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Thr Pro 
        835                 840                 845             


Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu 
    850                 855                 860                 


Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg 
865                 870                 875                 880 


Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys 
                885                 890                 895     


Thr 
    


<210>  5
<211>  876
<212>  PRT
<213>  homo sapiens

<400>  5

Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp 
            20                  25                  30          


Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu 
        35                  40                  45              


Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln 
    50                  55                  60                  


Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu 
65                  70                  75                  80  


Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu 
                85                  90                  95      


Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln 
            100                 105                 110         


Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln 
        115                 120                 125             


Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn 
    130                 135                 140                 


Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile 
145                 150                 155                 160 


Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu 
                165                 170                 175     


Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr 
            180                 185                 190         


Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys 
        195                 200                 205             


Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val 
    210                 215                 220                 


Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly 
225                 230                 235                 240 


Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val 
                245                 250                 255     


Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln 
            260                 265                 270         


Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly 
        275                 280                 285             


Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp 
    290                 295                 300                 


Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu 
305                 310                 315                 320 


Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile 
                325                 330                 335     


Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln 
            340                 345                 350         


Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys 
        355                 360                 365             


Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu 
    370                 375                 380                 


Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln 
385                 390                 395                 400 


Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu 
                405                 410                 415     


Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys 
            420                 425                 430         


His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys 
        435                 440                 445             


Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser 
    450                 455                 460                 


Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser 
465                 470                 475                 480 


Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg 
                485                 490                 495     


Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser 
            500                 505                 510         


Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile 
        515                 520                 525             


Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr 
    530                 535                 540                 


Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile 
545                 550                 555                 560 


Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln 
                565                 570                 575     


Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu 
            580                 585                 590         


Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser 
        595                 600                 605             


His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu 
    610                 615                 620                 


Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys 
625                 630                 635                 640 


Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser 
                645                 650                 655     


Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val 
            660                 665                 670         


Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val 
        675                 680                 685             


Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys 
    690                 695                 700                 


Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met 
705                 710                 715                 720 


Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr 
                725                 730                 735     


Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu 
            740                 745                 750         


Glu Leu Ser Thr Ala Thr Lys Lys Leu His Lys Arg Leu Ala Cys Lys 
        755                 760                 765             


Ile Phe Leu Ile Leu Arg Trp Phe Gly Lys Lys Arg Arg Glu Glu Asn 
    770                 775                 780                 


Cys Leu Gly Thr Arg Val Arg Asn Val Lys Phe Ile Met Gln Ile Cys 
785                 790                 795                 800 


Gln Gln Lys Lys Glu Lys Arg Asn Trp Leu Pro Ala Gln Asp Thr Asp 
                805                 810                 815     


Ser Ala Thr Phe His Pro Thr His Gln Arg Ile Phe Gly Lys Leu Val 
            820                 825                 830         


Phe Leu Pro Leu Arg Leu Val Trp Lys Glu Val Ile Leu Arg Lys Ile 
        835                 840                 845             


Leu Ile Leu Val Leu Val Gln Lys Asp Val Ser Leu Thr Thr Gln Tyr 
    850                 855                 860                 


Phe Leu Gln Lys Ala Arg Ser Arg Arg His Arg Arg 
865                 870                 875     


<210>  6
<211>  799
<212>  PRT
<213>  homo sapiens

<400>  6

Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln Asn Leu 
1               5                   10                  15      


Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln Glu Glu 
            20                  25                  30          


Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn Asp Gln 
        35                  40                  45              


Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile Pro Asp 
    50                  55                  60                  


Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu Arg Arg 
65                  70                  75                  80  


Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr Lys Leu 
                85                  90                  95      


Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys Ser Ser 
            100                 105                 110         


Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val Ala Asp 
        115                 120                 125             


Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly Thr Ser 
    130                 135                 140                 


Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val Val Ala 
145                 150                 155                 160 


Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln Gly Pro 
                165                 170                 175     


Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly Asn His 
            180                 185                 190         


Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp Ser Leu 
        195                 200                 205             


Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu Leu Pro 
    210                 215                 220                 


Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile Lys Ser 
225                 230                 235                 240 


Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln Pro Gly 
                245                 250                 255     


Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys Ile Ser 
            260                 265                 270         


Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu Phe Thr 
        275                 280                 285             


His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln Ser Ser 
    290                 295                 300                 


Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu Gly Glu 
305                 310                 315                 320 


Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys His Leu 
                325                 330                 335     


Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys Lys Thr 
            340                 345                 350         


Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser Phe Asp 
        355                 360                 365             


Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser Met Asn 
    370                 375                 380                 


Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg Phe Ser 
385                 390                 395                 400 


Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser Lys Asn 
                405                 410                 415     


Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile Pro Lys 
            420                 425                 430         


Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr Leu Pro 
        435                 440                 445             


Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile Leu Gln 
    450                 455                 460                 


Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln Ile Lys 
465                 470                 475                 480 


Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu Ser Leu 
                485                 490                 495     


Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser His Glu 
            500                 505                 510         


Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu Leu Ala 
        515                 520                 525             


Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys Ser Leu 
    530                 535                 540                 


Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser Ile Asp 
545                 550                 555                 560 


Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val Ile Asp 
                565                 570                 575     


Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val Asp Met 
            580                 585                 590         


Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys Lys Gln 
        595                 600                 605             


Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met Asn Asp 
    610                 615                 620                 


Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr Glu Ser 
625                 630                 635                 640 


Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu Glu Leu 
                645                 650                 655     


Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln Asp Lys 
            660                 665                 670         


Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp Glu Arg 
        675                 680                 685             


Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg Lys Lys 
    690                 695                 700                 


Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys Glu Ile 
705                 710                 715                 720 


Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu Ala Ser 
                725                 730                 735     


Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Thr Pro Glu Asn 
            740                 745                 750         


Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu Arg Gly 
        755                 760                 765             


Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg Arg Gln 
    770                 775                 780                 


Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys Thr 
785                 790                 795                 


<210>  7
<211>  623
<212>  PRT
<213>  homo sapiens

<400>  7

Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly Asn His 
1               5                   10                  15      


Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp Ser Leu 
            20                  25                  30          


Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu Leu Pro 
        35                  40                  45              


Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile Lys Ser 
    50                  55                  60                  


Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln Pro Gly 
65                  70                  75                  80  


Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys Ile Ser 
                85                  90                  95      


Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu Phe Thr 
            100                 105                 110         


His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln Ser Ser 
        115                 120                 125             


Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu Gly Glu 
    130                 135                 140                 


Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys His Leu 
145                 150                 155                 160 


Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys Lys Thr 
                165                 170                 175     


Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser Phe Asp 
            180                 185                 190         


Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser Met Asn 
        195                 200                 205             


Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg Phe Ser 
    210                 215                 220                 


Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser Lys Asn 
225                 230                 235                 240 


Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile Pro Lys 
                245                 250                 255     


Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr Leu Pro 
            260                 265                 270         


Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile Leu Gln 
        275                 280                 285             


Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln Ile Lys 
    290                 295                 300                 


Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu Ser Leu 
305                 310                 315                 320 


Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser His Glu 
                325                 330                 335     


Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu Leu Ala 
            340                 345                 350         


Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys Ser Leu 
        355                 360                 365             


Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser Ile Asp 
    370                 375                 380                 


Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val Ile Asp 
385                 390                 395                 400 


Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val Asp Met 
                405                 410                 415     


Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys Lys Gln 
            420                 425                 430         


Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met Asn Asp 
        435                 440                 445             


Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr Glu Ser 
    450                 455                 460                 


Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu Glu Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln Asp Lys 
                485                 490                 495     


Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp Glu Arg 
            500                 505                 510         


Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg Lys Lys 
        515                 520                 525             


Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys Glu Ile 
    530                 535                 540                 


Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu Ala Ser 
545                 550                 555                 560 


Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Thr Pro Glu Asn 
                565                 570                 575     


Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu Arg Gly 
            580                 585                 590         


Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg Arg Gln 
        595                 600                 605             


Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys Thr 
    610                 615                 620             


<210>  8
<211>  602
<212>  PRT
<213>  homo sapiens

<400>  8

Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly Asn His 
1               5                   10                  15      


Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp Ser Leu 
            20                  25                  30          


Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu Leu Pro 
        35                  40                  45              


Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile Lys Ser 
    50                  55                  60                  


Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln Pro Gly 
65                  70                  75                  80  


Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys Ile Ser 
                85                  90                  95      


Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu Phe Thr 
            100                 105                 110         


His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln Ser Ser 
        115                 120                 125             


Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu Gly Glu 
    130                 135                 140                 


Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys His Leu 
145                 150                 155                 160 


Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys Lys Thr 
                165                 170                 175     


Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser Phe Asp 
            180                 185                 190         


Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser Met Asn 
        195                 200                 205             


Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg Phe Ser 
    210                 215                 220                 


Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser Lys Asn 
225                 230                 235                 240 


Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile Pro Lys 
                245                 250                 255     


Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr Leu Pro 
            260                 265                 270         


Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile Leu Gln 
        275                 280                 285             


Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln Ile Lys 
    290                 295                 300                 


Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu Ser Leu 
305                 310                 315                 320 


Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser His Glu 
                325                 330                 335     


Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu Leu Ala 
            340                 345                 350         


Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys Ser Leu 
        355                 360                 365             


Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser Ile Asp 
    370                 375                 380                 


Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val Ile Asp 
385                 390                 395                 400 


Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val Asp Met 
                405                 410                 415     


Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys Lys Gln 
            420                 425                 430         


Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met Asn Asp 
        435                 440                 445             


Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr Glu Ser 
    450                 455                 460                 


Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu Glu Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Lys Leu His Lys Arg Leu Ala Cys Lys Ile Phe 
                485                 490                 495     


Leu Ile Leu Arg Trp Phe Gly Lys Lys Arg Arg Glu Glu Asn Cys Leu 
            500                 505                 510         


Gly Thr Arg Val Arg Asn Val Lys Phe Ile Met Gln Ile Cys Gln Gln 
        515                 520                 525             


Lys Lys Glu Lys Arg Asn Trp Leu Pro Ala Gln Asp Thr Asp Ser Ala 
    530                 535                 540                 


Thr Phe His Pro Thr His Gln Arg Ile Phe Gly Lys Leu Val Phe Leu 
545                 550                 555                 560 


Pro Leu Arg Leu Val Trp Lys Glu Val Ile Leu Arg Lys Ile Leu Ile 
                565                 570                 575     


Leu Val Leu Val Gln Lys Asp Val Ser Leu Thr Thr Gln Tyr Phe Leu 
            580                 585                 590         


Gln Lys Ala Arg Ser Arg Arg His Arg Arg 
        595                 600         


<210>  9
<211>  708
<212>  PRT
<213>  homo sapiens

<400>  9

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser 
        595                 600                 605             


Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr 
625                 630                 635                 640 


Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe 
                645                 650                 655     


Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser 
            660                 665                 670         


Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser 
        675                 680                 685             


Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg 
    690                 695                 700                 


Arg Asn Arg Arg 
705             


<210>  10
<211>  680
<212>  PRT
<213>  homo sapiens

<400>  10

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Phe Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr 
        595                 600                 605             


Thr Lys Asn Tyr Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu 
    610                 615                 620                 


Glu Asp Ile Phe Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser 
625                 630                 635                 640 


Thr Ser Ser Ser Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val 
                645                 650                 655     


Asp Phe Glu Ser Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr 
            660                 665                 670         


Ser Ser Leu Arg Arg Asn Arg Arg 
        675                 680 


<210>  11
<211>  707
<212>  PRT
<213>  homo sapiens

<400>  11

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser Lys 
        595                 600                 605             


Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe Lys 
    610                 615                 620                 


Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr Ser 
625                 630                 635                 640 


Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe Pro 
                645                 650                 655     


Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser Lys 
            660                 665                 670         


Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser Ser 
        675                 680                 685             


Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg Arg 
    690                 695                 700                 


Asn Arg Arg 
705         


<210>  12
<211>  708
<212>  PRT
<213>  homo sapiens

<400>  12

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser 
        595                 600                 605             


Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr 
625                 630                 635                 640 


Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe 
                645                 650                 655     


Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser 
            660                 665                 670         


Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser 
        675                 680                 685             


Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg 
    690                 695                 700                 


Arg Asn Arg Arg 
705             


<210>  13
<211>  707
<212>  PRT
<213>  homo sapiens

<400>  13

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser Lys 
        595                 600                 605             


Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe Lys 
    610                 615                 620                 


Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr Ser 
625                 630                 635                 640 


Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe Pro 
                645                 650                 655     


Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser Lys 
            660                 665                 670         


Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser Ser 
        675                 680                 685             


Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg Arg 
    690                 695                 700                 


Asn Arg Arg 
705         


<210>  14
<211>  552
<212>  PRT
<213>  homo sapiens

<400>  14

Met Ser Val Glu Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly 
1               5                   10                  15      


Ser Thr Lys Ile Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg 
            20                  25                  30          


Leu Tyr Arg Met Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys 
        35                  40                  45              


Glu Asp Glu Asn Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg 
    50                  55                  60                  


Ser Lys His Gly Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp 
65                  70                  75                  80  


Phe Ile Asp Leu Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala 
                85                  90                  95      


Pro Thr Lys Asn Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser 
            100                 105                 110         


Ser Val Val Thr Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val 
        115                 120                 125             


Gly Leu Leu Arg Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro 
    130                 135                 140                 


Leu His Thr Val Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn 
145                 150                 155                 160 


His Pro Asp Ile Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile 
                165                 170                 175     


Gln Ser Phe Cys Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu 
            180                 185                 190         


Arg Glu Arg Leu Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg 
        195                 200                 205             


Leu Arg Val Asp Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg 
    210                 215                 220                 


Phe Ser Gln Lys Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile 
225                 230                 235                 240 


His Phe Phe Arg His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile 
                245                 250                 255     


Asn Phe Gly Lys Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg 
            260                 265                 270         


Val Glu Asp Leu Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val 
        275                 280                 285             


Gln Leu Ser Leu Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu 
    290                 295                 300                 


Phe Val Asp Lys Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr 
305                 310                 315                 320 


Gln Leu Glu Lys Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala 
                325                 330                 335     


Leu Glu Asp Lys Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg 
            340                 345                 350         


Gln Lys Asn Thr Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr 
        355                 360                 365             


Arg Ala Arg Ala Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe 
    370                 375                 380                 


Ser Ala Asp Asp Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn 
385                 390                 395                 400 


Asp Ser Asp Asp Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg 
                405                 410                 415     


Gly Arg Gly Arg Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly 
            420                 425                 430         


Gly Ser Gln Arg Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg 
        435                 440                 445             


Ser Arg Asn Ser Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile 
    450                 455                 460                 


Ile Asp Ala Phe Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr 
465                 470                 475                 480 


Thr Lys Asn Tyr Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu 
                485                 490                 495     


Glu Asp Ile Phe Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser 
            500                 505                 510         


Thr Ser Ser Ser Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val 
        515                 520                 525             


Asp Phe Glu Ser Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr 
    530                 535                 540                 


Ser Ser Leu Arg Arg Asn Arg Arg 
545                 550         


<210>  15
<211>  1312
<212>  PRT
<213>  homo sapiens

<400>  15

Met Ser Arg Ile Glu Lys Met Ser Ile Leu Gly Val Arg Ser Phe Gly 
1               5                   10                  15      


Ile Glu Asp Lys Asp Lys Gln Ile Ile Thr Phe Phe Ser Pro Leu Thr 
            20                  25                  30          


Ile Leu Val Gly Pro Asn Gly Ala Gly Lys Thr Thr Ile Ile Glu Cys 
        35                  40                  45              


Leu Lys Tyr Ile Cys Thr Gly Asp Phe Pro Pro Gly Thr Lys Gly Asn 
    50                  55                  60                  


Thr Phe Val His Asp Pro Lys Val Ala Gln Glu Thr Asp Val Arg Ala 
65                  70                  75                  80  


Gln Ile Arg Leu Gln Phe Arg Asp Val Asn Gly Glu Leu Ile Ala Val 
                85                  90                  95      


Gln Arg Ser Met Val Cys Thr Gln Lys Ser Lys Lys Thr Glu Phe Lys 
            100                 105                 110         


Thr Leu Glu Gly Val Ile Thr Arg Thr Lys His Gly Glu Lys Val Ser 
        115                 120                 125             


Leu Ser Ser Lys Cys Ala Glu Ile Asp Arg Glu Met Ile Ser Ser Leu 
    130                 135                 140                 


Gly Val Ser Lys Ala Val Leu Asn Asn Val Ile Phe Cys His Gln Glu 
145                 150                 155                 160 


Asp Ser Asn Trp Pro Leu Ser Glu Gly Lys Ala Leu Lys Gln Lys Phe 
                165                 170                 175     


Asp Glu Ile Phe Ser Ala Thr Arg Tyr Ile Lys Ala Leu Glu Thr Leu 
            180                 185                 190         


Arg Gln Val Arg Gln Thr Gln Gly Gln Lys Val Lys Glu Tyr Gln Met 
        195                 200                 205             


Glu Leu Lys Tyr Leu Lys Gln Tyr Lys Glu Lys Ala Cys Glu Ile Arg 
    210                 215                 220                 


Asp Gln Ile Thr Ser Lys Glu Ala Gln Leu Thr Ser Ser Lys Glu Ile 
225                 230                 235                 240 


Val Lys Ser Tyr Glu Asn Glu Leu Asp Pro Leu Lys Asn Arg Leu Lys 
                245                 250                 255     


Glu Ile Glu His Asn Leu Ser Lys Ile Met Lys Leu Asp Asn Glu Ile 
            260                 265                 270         


Lys Ala Leu Asp Ser Arg Lys Lys Gln Met Glu Lys Asp Asn Ser Glu 
        275                 280                 285             


Leu Glu Glu Lys Met Glu Lys Val Phe Gln Gly Thr Asp Glu Gln Leu 
    290                 295                 300                 


Asn Asp Leu Tyr His Asn His Gln Arg Thr Val Arg Glu Lys Glu Arg 
305                 310                 315                 320 


Lys Leu Val Asp Cys His Arg Glu Leu Glu Lys Leu Asn Lys Glu Ser 
                325                 330                 335     


Arg Leu Leu Asn Gln Glu Lys Ser Glu Leu Leu Val Glu Gln Gly Arg 
            340                 345                 350         


Leu Gln Leu Gln Ala Asp Arg His Gln Glu His Ile Arg Ala Arg Asp 
        355                 360                 365             


Ser Leu Ile Gln Ser Leu Ala Thr Gln Leu Glu Leu Asp Gly Phe Glu 
    370                 375                 380                 


Arg Gly Pro Phe Ser Glu Arg Gln Ile Lys Asn Phe His Lys Leu Val 
385                 390                 395                 400 


Arg Glu Arg Gln Glu Gly Glu Ala Lys Thr Ala Asn Gln Leu Met Asn 
                405                 410                 415     


Asp Phe Ala Glu Lys Glu Thr Leu Lys Gln Lys Gln Ile Asp Glu Ile 
            420                 425                 430         


Arg Asp Lys Lys Thr Gly Leu Gly Arg Ile Ile Glu Leu Lys Ser Glu 
        435                 440                 445             


Ile Leu Ser Lys Lys Gln Asn Glu Leu Lys Asn Val Lys Tyr Glu Leu 
    450                 455                 460                 


Gln Gln Leu Glu Gly Ser Ser Asp Arg Ile Leu Glu Leu Asp Gln Glu 
465                 470                 475                 480 


Leu Ile Lys Ala Glu Arg Glu Leu Ser Lys Ala Glu Lys Asn Ser Asn 
                485                 490                 495     


Val Glu Thr Leu Lys Met Glu Val Ile Ser Leu Gln Asn Glu Lys Ala 
            500                 505                 510         


Asp Leu Asp Arg Thr Leu Arg Lys Leu Asp Gln Glu Met Glu Gln Leu 
        515                 520                 525             


Asn His His Thr Thr Thr Arg Thr Gln Met Glu Met Leu Thr Lys Asp 
    530                 535                 540                 


Lys Ala Asp Lys Asp Glu Gln Ile Arg Lys Ile Lys Ser Arg His Ser 
545                 550                 555                 560 


Asp Glu Leu Thr Ser Leu Leu Gly Tyr Phe Pro Asn Lys Lys Gln Leu 
                565                 570                 575     


Glu Asp Trp Leu His Ser Lys Ser Lys Glu Ile Asn Gln Thr Arg Asp 
            580                 585                 590         


Arg Leu Ala Lys Leu Asn Lys Glu Leu Ala Ser Ser Glu Gln Asn Lys 
        595                 600                 605             


Asn His Ile Asn Asn Glu Leu Lys Arg Lys Glu Glu Gln Leu Ser Ser 
    610                 615                 620                 


Tyr Glu Asp Lys Leu Phe Asp Val Cys Gly Ser Gln Asp Phe Glu Ser 
625                 630                 635                 640 


Asp Leu Asp Arg Leu Lys Glu Glu Ile Glu Lys Ser Ser Lys Gln Arg 
                645                 650                 655     


Ala Met Leu Ala Gly Ala Thr Ala Val Tyr Ser Gln Phe Ile Thr Gln 
            660                 665                 670         


Leu Thr Asp Glu Asn Gln Ser Cys Cys Pro Val Cys Gln Arg Val Phe 
        675                 680                 685             


Gln Thr Glu Ala Glu Leu Gln Glu Val Ile Ser Asp Leu Gln Ser Lys 
    690                 695                 700                 


Leu Arg Leu Ala Pro Asp Lys Leu Lys Ser Thr Glu Ser Glu Leu Lys 
705                 710                 715                 720 


Lys Lys Glu Lys Arg Arg Asp Glu Met Leu Gly Leu Val Pro Met Arg 
                725                 730                 735     


Gln Ser Ile Ile Asp Leu Lys Glu Lys Glu Ile Pro Glu Leu Arg Asn 
            740                 745                 750         


Lys Leu Gln Asn Val Asn Arg Asp Ile Gln Arg Leu Lys Asn Asp Ile 
        755                 760                 765             


Glu Glu Gln Glu Thr Leu Leu Gly Thr Ile Met Pro Glu Glu Glu Ser 
    770                 775                 780                 


Ala Lys Val Cys Leu Thr Asp Val Thr Ile Met Glu Arg Phe Gln Met 
785                 790                 795                 800 


Glu Leu Lys Asp Val Glu Arg Lys Ile Ala Gln Gln Ala Ala Lys Leu 
                805                 810                 815     


Gln Gly Ile Asp Leu Asp Arg Thr Val Gln Gln Val Asn Gln Glu Lys 
            820                 825                 830         


Gln Glu Lys Gln His Lys Leu Asp Thr Val Ser Ser Lys Ile Glu Leu 
        835                 840                 845             


Asn Arg Lys Leu Ile Gln Asp Gln Gln Glu Gln Ile Gln His Leu Lys 
    850                 855                 860                 


Ser Thr Thr Asn Glu Leu Lys Ser Glu Lys Leu Gln Ile Ser Thr Asn 
865                 870                 875                 880 


Leu Gln Arg Arg Gln Gln Leu Glu Glu Gln Thr Val Glu Leu Ser Thr 
                885                 890                 895     


Glu Val Gln Ser Leu Tyr Arg Glu Ile Lys Asp Ala Lys Glu Gln Val 
            900                 905                 910         


Ser Pro Leu Glu Thr Thr Leu Glu Lys Phe Gln Gln Glu Lys Glu Glu 
        915                 920                 925             


Leu Ile Asn Lys Lys Asn Thr Ser Asn Lys Ile Ala Gln Asp Lys Leu 
    930                 935                 940                 


Asn Asp Ile Lys Glu Lys Val Lys Asn Ile His Gly Tyr Met Lys Asp 
945                 950                 955                 960 


Ile Glu Asn Tyr Ile Gln Asp Gly Lys Asp Asp Tyr Lys Lys Gln Lys 
                965                 970                 975     


Glu Thr Glu Leu Asn Lys Val Ile Ala Gln Leu Ser Glu Cys Glu Lys 
            980                 985                 990         


His Lys Glu Lys Ile Asn Glu Asp  Met Arg Leu Met Arg  Gln Asp Ile 
        995                 1000                 1005             


Asp Thr  Gln Lys Ile Gln Glu  Arg Trp Leu Gln Asp  Asn Leu Thr 
    1010                 1015                 1020             


Leu Arg  Lys Arg Asn Glu Glu  Leu Lys Glu Val Glu  Glu Glu Arg 
    1025                 1030                 1035             


Lys Gln  His Leu Lys Glu Met  Gly Gln Met Gln Val  Leu Gln Met 
    1040                 1045                 1050             


Lys Ser  Glu His Gln Lys Leu  Glu Glu Asn Ile Asp  Asn Ile Lys 
    1055                 1060                 1065             


Arg Asn  His Asn Leu Ala Leu  Gly Arg Gln Lys Gly  Tyr Glu Glu 
    1070                 1075                 1080             


Glu Ile  Ile His Phe Lys Lys  Glu Leu Arg Glu Pro  Gln Phe Arg 
    1085                 1090                 1095             


Asp Ala  Glu Glu Lys Tyr Arg  Glu Met Met Ile Val  Met Arg Thr 
    1100                 1105                 1110             


Thr Glu  Leu Val Asn Lys Asp  Leu Asp Ile Tyr Tyr  Lys Thr Leu 
    1115                 1120                 1125             


Asp Gln  Ala Ile Met Lys Phe  His Ser Met Lys Met  Glu Glu Ile 
    1130                 1135                 1140             


Asn Lys  Ile Ile Arg Asp Leu  Trp Arg Ser Thr Tyr  Arg Gly Gln 
    1145                 1150                 1155             


Asp Ile  Glu Tyr Ile Glu Ile  Arg Ser Asp Ala Asp  Glu Asn Val 
    1160                 1165                 1170             


Ser Ala  Ser Asp Lys Arg Arg  Asn Tyr Asn Tyr Arg  Val Val Met 
    1175                 1180                 1185             


Leu Lys  Gly Asp Thr Ala Leu  Asp Met Arg Gly Arg  Cys Ser Ala 
    1190                 1195                 1200             


Gly Gln  Lys Val Leu Ala Ser  Leu Ile Ile Arg Leu  Ala Leu Ala 
    1205                 1210                 1215             


Glu Thr  Phe Cys Leu Asn Cys  Gly Ile Ile Ala Leu  Asp Glu Pro 
    1220                 1225                 1230             


Thr Thr  Asn Leu Asp Arg Glu  Asn Ile Glu Ser Leu  Ala His Ala 
    1235                 1240                 1245             


Leu Val  Glu Ile Ile Lys Ser  Arg Ser Gln Gln Arg  Asn Phe Gln 
    1250                 1255                 1260             


Leu Leu  Val Ile Thr His Asp  Glu Asp Phe Val Glu  Leu Leu Gly 
    1265                 1270                 1275             


Arg Ser  Glu Tyr Val Glu Lys  Phe Tyr Arg Ile Lys  Lys Asn Ile 
    1280                 1285                 1290             


Asp Gln  Cys Ser Glu Ile Val  Lys Cys Ser Val Ser  Ser Leu Gly 
    1295                 1300                 1305             


Phe Asn  Val His 
    1310         


<210>  16
<211>  754
<212>  PRT
<213>  homo sapiens

<400>  16

Met Trp Lys Leu Leu Pro Ala Ala Gly Pro Ala Gly Gly Glu Pro Tyr 
1               5                   10                  15      


Arg Leu Leu Thr Gly Val Glu Tyr Val Val Gly Arg Lys Asn Cys Ala 
            20                  25                  30          


Ile Leu Ile Glu Asn Asp Gln Ser Ile Ser Arg Asn His Ala Val Leu 
        35                  40                  45              


Thr Ala Asn Phe Ser Val Thr Asn Leu Ser Gln Thr Asp Glu Ile Pro 
    50                  55                  60                  


Val Leu Thr Leu Lys Asp Asn Ser Lys Tyr Gly Thr Phe Val Asn Glu 
65                  70                  75                  80  


Glu Lys Met Gln Asn Gly Phe Ser Arg Thr Leu Lys Ser Gly Asp Gly 
                85                  90                  95      


Ile Thr Phe Gly Val Phe Gly Ser Lys Phe Arg Ile Glu Tyr Glu Pro 
            100                 105                 110         


Leu Val Ala Cys Ser Ser Cys Leu Asp Val Ser Gly Lys Thr Ala Leu 
        115                 120                 125             


Asn Gln Ala Ile Leu Gln Leu Gly Gly Phe Thr Val Asn Asn Trp Thr 
    130                 135                 140                 


Glu Glu Cys Thr His Leu Val Met Val Ser Val Lys Val Thr Ile Lys 
145                 150                 155                 160 


Thr Ile Cys Ala Leu Ile Cys Gly Arg Pro Ile Val Lys Pro Glu Tyr 
                165                 170                 175     


Phe Thr Glu Phe Leu Lys Ala Val Glu Ser Lys Lys Gln Pro Pro Gln 
            180                 185                 190         


Ile Glu Ser Phe Tyr Pro Pro Leu Asp Glu Pro Ser Ile Gly Ser Lys 
        195                 200                 205             


Asn Val Asp Leu Ser Gly Arg Gln Glu Arg Lys Gln Ile Phe Lys Gly 
    210                 215                 220                 


Lys Thr Phe Ile Phe Leu Asn Ala Lys Gln His Lys Lys Leu Ser Ser 
225                 230                 235                 240 


Ala Val Val Phe Gly Gly Gly Glu Ala Arg Leu Ile Thr Glu Glu Asn 
                245                 250                 255     


Glu Glu Glu His Asn Phe Phe Leu Ala Pro Gly Thr Cys Val Val Asp 
            260                 265                 270         


Thr Gly Ile Thr Asn Ser Gln Thr Leu Ile Pro Asp Cys Gln Lys Lys 
        275                 280                 285             


Trp Ile Gln Ser Ile Met Asp Met Leu Gln Arg Gln Gly Leu Arg Pro 
    290                 295                 300                 


Ile Pro Glu Ala Glu Ile Gly Leu Ala Val Ile Phe Met Thr Thr Lys 
305                 310                 315                 320 


Asn Tyr Cys Asp Pro Gln Gly His Pro Ser Thr Gly Leu Lys Thr Thr 
                325                 330                 335     


Thr Pro Gly Pro Ser Leu Ser Gln Gly Val Ser Val Asp Glu Lys Leu 
            340                 345                 350         


Met Pro Ser Ala Pro Val Asn Thr Thr Thr Tyr Val Ala Asp Thr Glu 
        355                 360                 365             


Ser Glu Gln Ala Asp Thr Trp Asp Leu Ser Glu Arg Pro Lys Glu Ile 
    370                 375                 380                 


Lys Val Ser Lys Met Glu Gln Lys Phe Arg Met Leu Ser Gln Asp Ala 
385                 390                 395                 400 


Pro Thr Val Lys Glu Ser Cys Lys Thr Ser Ser Asn Asn Asn Ser Met 
                405                 410                 415     


Val Ser Asn Thr Leu Ala Lys Met Arg Ile Pro Asn Tyr Gln Leu Ser 
            420                 425                 430         


Pro Thr Lys Leu Pro Ser Ile Asn Lys Ser Lys Asp Arg Ala Ser Gln 
        435                 440                 445             


Gln Gln Gln Thr Asn Ser Ile Arg Asn Tyr Phe Gln Pro Ser Thr Lys 
    450                 455                 460                 


Lys Arg Glu Arg Asp Glu Glu Asn Gln Glu Met Ser Ser Cys Lys Ser 
465                 470                 475                 480 


Ala Arg Ile Glu Thr Ser Cys Ser Leu Leu Glu Gln Thr Gln Pro Ala 
                485                 490                 495     


Thr Pro Ser Leu Trp Lys Asn Lys Glu Gln His Leu Ser Glu Asn Glu 
            500                 505                 510         


Pro Val Asp Thr Asn Ser Asp Asn Asn Leu Phe Thr Asp Thr Asp Leu 
        515                 520                 525             


Lys Ser Ile Val Lys Asn Ser Ala Ser Lys Ser His Ala Ala Glu Lys 
    530                 535                 540                 


Leu Arg Ser Asn Lys Lys Arg Glu Met Asp Asp Val Ala Ile Glu Asp 
545                 550                 555                 560 


Glu Val Leu Glu Gln Leu Phe Lys Asp Thr Lys Pro Glu Leu Glu Ile 
                565                 570                 575     


Asp Val Lys Val Gln Lys Gln Glu Glu Asp Val Asn Val Arg Lys Arg 
            580                 585                 590         


Pro Arg Met Asp Ile Glu Thr Asn Asp Thr Phe Ser Asp Glu Ala Val 
        595                 600                 605             


Pro Glu Ser Ser Lys Ile Ser Gln Glu Asn Glu Ile Gly Lys Lys Arg 
    610                 615                 620                 


Glu Leu Lys Glu Asp Ser Leu Trp Ser Ala Lys Glu Ile Ser Asn Asn 
625                 630                 635                 640 


Asp Lys Leu Gln Asp Asp Ser Glu Met Leu Pro Lys Lys Leu Leu Leu 
                645                 650                 655     


Thr Glu Phe Arg Ser Leu Val Ile Lys Asn Ser Thr Ser Arg Asn Pro 
            660                 665                 670         


Ser Gly Ile Asn Asp Asp Tyr Gly Gln Leu Lys Asn Phe Lys Lys Phe 
        675                 680                 685             


Lys Lys Val Thr Tyr Pro Gly Ala Gly Lys Leu Pro His Ile Ile Gly 
    690                 695                 700                 


Gly Ser Asp Leu Ile Ala His His Ala Arg Lys Asn Thr Glu Leu Glu 
705                 710                 715                 720 


Glu Trp Leu Arg Gln Glu Met Glu Val Gln Asn Gln His Ala Lys Glu 
                725                 730                 735     


Glu Ser Leu Ala Asp Asp Leu Phe Arg Tyr Asn Pro Tyr Leu Lys Arg 
            740                 745                 750         


Arg Arg 
        


<210>  17
<211>  672
<212>  PRT
<213>  homo sapiens

<400>  17

Met Gln Asn Gly Phe Ser Arg Thr Leu Lys Ser Gly Asp Gly Ile Thr 
1               5                   10                  15      


Phe Gly Val Phe Gly Ser Lys Phe Arg Ile Glu Tyr Glu Pro Leu Val 
            20                  25                  30          


Ala Cys Ser Ser Cys Leu Asp Val Ser Gly Lys Thr Ala Leu Asn Gln 
        35                  40                  45              


Ala Ile Leu Gln Leu Gly Gly Phe Thr Val Asn Asn Trp Thr Glu Glu 
    50                  55                  60                  


Cys Thr His Leu Val Met Val Ser Val Lys Val Thr Ile Lys Thr Ile 
65                  70                  75                  80  


Cys Ala Leu Ile Cys Gly Arg Pro Ile Val Lys Pro Glu Tyr Phe Thr 
                85                  90                  95      


Glu Phe Leu Lys Ala Val Glu Ser Lys Lys Gln Pro Pro Gln Ile Glu 
            100                 105                 110         


Ser Phe Tyr Pro Pro Leu Asp Glu Pro Ser Ile Gly Ser Lys Asn Val 
        115                 120                 125             


Asp Leu Ser Gly Arg Gln Glu Arg Lys Gln Ile Phe Lys Gly Lys Thr 
    130                 135                 140                 


Phe Ile Phe Leu Asn Ala Lys Gln His Lys Lys Leu Ser Ser Ala Val 
145                 150                 155                 160 


Val Phe Gly Gly Gly Glu Ala Arg Leu Ile Thr Glu Glu Asn Glu Glu 
                165                 170                 175     


Glu His Asn Phe Phe Leu Ala Pro Gly Thr Cys Val Val Asp Thr Gly 
            180                 185                 190         


Ile Thr Asn Ser Gln Thr Leu Ile Pro Asp Cys Gln Lys Lys Trp Ile 
        195                 200                 205             


Gln Ser Ile Met Asp Met Leu Gln Arg Gln Gly Leu Arg Pro Ile Pro 
    210                 215                 220                 


Glu Ala Glu Ile Gly Leu Ala Val Ile Phe Met Thr Thr Lys Asn Tyr 
225                 230                 235                 240 


Cys Asp Pro Gln Gly His Pro Ser Thr Gly Leu Lys Thr Thr Thr Pro 
                245                 250                 255     


Gly Pro Ser Leu Ser Gln Gly Val Ser Val Asp Glu Lys Leu Met Pro 
            260                 265                 270         


Ser Ala Pro Val Asn Thr Thr Thr Tyr Val Ala Asp Thr Glu Ser Glu 
        275                 280                 285             


Gln Ala Asp Thr Trp Asp Leu Ser Glu Arg Pro Lys Glu Ile Lys Val 
    290                 295                 300                 


Ser Lys Met Glu Gln Lys Phe Arg Met Leu Ser Gln Asp Ala Pro Thr 
305                 310                 315                 320 


Val Lys Glu Ser Cys Lys Thr Ser Ser Asn Asn Asn Ser Met Val Ser 
                325                 330                 335     


Asn Thr Leu Ala Lys Met Arg Ile Pro Asn Tyr Gln Leu Ser Pro Thr 
            340                 345                 350         


Lys Leu Pro Ser Ile Asn Lys Ser Lys Asp Arg Ala Ser Gln Gln Gln 
        355                 360                 365             


Gln Thr Asn Ser Ile Arg Asn Tyr Phe Gln Pro Ser Thr Lys Lys Arg 
    370                 375                 380                 


Glu Arg Asp Glu Glu Asn Gln Glu Met Ser Ser Cys Lys Ser Ala Arg 
385                 390                 395                 400 


Ile Glu Thr Ser Cys Ser Leu Leu Glu Gln Thr Gln Pro Ala Thr Pro 
                405                 410                 415     


Ser Leu Trp Lys Asn Lys Glu Gln His Leu Ser Glu Asn Glu Pro Val 
            420                 425                 430         


Asp Thr Asn Ser Asp Asn Asn Leu Phe Thr Asp Thr Asp Leu Lys Ser 
        435                 440                 445             


Ile Val Lys Asn Ser Ala Ser Lys Ser His Ala Ala Glu Lys Leu Arg 
    450                 455                 460                 


Ser Asn Lys Lys Arg Glu Met Asp Asp Val Ala Ile Glu Asp Glu Val 
465                 470                 475                 480 


Leu Glu Gln Leu Phe Lys Asp Thr Lys Pro Glu Leu Glu Ile Asp Val 
                485                 490                 495     


Lys Val Gln Lys Gln Glu Glu Asp Val Asn Val Arg Lys Arg Pro Arg 
            500                 505                 510         


Met Asp Ile Glu Thr Asn Asp Thr Phe Ser Asp Glu Ala Val Pro Glu 
        515                 520                 525             


Ser Ser Lys Ile Ser Gln Glu Asn Glu Ile Gly Lys Lys Arg Glu Leu 
    530                 535                 540                 


Lys Glu Asp Ser Leu Trp Ser Ala Lys Glu Ile Ser Asn Asn Asp Lys 
545                 550                 555                 560 


Leu Gln Asp Asp Ser Glu Met Leu Pro Lys Lys Leu Leu Leu Thr Glu 
                565                 570                 575     


Phe Arg Ser Leu Val Ile Lys Asn Ser Thr Ser Arg Asn Pro Ser Gly 
            580                 585                 590         


Ile Asn Asp Asp Tyr Gly Gln Leu Lys Asn Phe Lys Lys Phe Lys Lys 
        595                 600                 605             


Val Thr Tyr Pro Gly Ala Gly Lys Leu Pro His Ile Ile Gly Gly Ser 
    610                 615                 620                 


Asp Leu Ile Ala His His Ala Arg Lys Asn Thr Glu Leu Glu Glu Trp 
625                 630                 635                 640 


Leu Arg Gln Glu Met Glu Val Gln Asn Gln His Ala Lys Glu Glu Ser 
                645                 650                 655     


Leu Ala Asp Asp Leu Phe Arg Tyr Asn Pro Tyr Leu Lys Arg Arg Arg 
            660                 665                 670         


<210>  18
<211>  672
<212>  PRT
<213>  homo sapiens

<400>  18

Met Gln Asn Gly Phe Ser Arg Thr Leu Lys Ser Gly Asp Gly Ile Thr 
1               5                   10                  15      


Phe Gly Val Phe Gly Ser Lys Phe Arg Ile Glu Tyr Glu Pro Leu Val 
            20                  25                  30          


Ala Cys Ser Ser Cys Leu Asp Val Ser Gly Lys Thr Ala Leu Asn Gln 
        35                  40                  45              


Ala Ile Leu Gln Leu Gly Gly Phe Thr Val Asn Asn Trp Thr Glu Glu 
    50                  55                  60                  


Cys Thr His Leu Val Met Val Ser Val Lys Val Thr Ile Lys Thr Ile 
65                  70                  75                  80  


Cys Ala Leu Ile Cys Gly Arg Pro Ile Val Lys Pro Glu Tyr Phe Thr 
                85                  90                  95      


Glu Phe Leu Lys Ala Val Glu Ser Lys Lys Gln Pro Pro Gln Ile Glu 
            100                 105                 110         


Ser Phe Tyr Pro Pro Leu Asp Glu Pro Ser Ile Gly Ser Lys Asn Val 
        115                 120                 125             


Asp Leu Ser Gly Arg Gln Glu Arg Lys Gln Ile Phe Lys Gly Lys Thr 
    130                 135                 140                 


Phe Ile Phe Leu Asn Ala Lys Gln His Lys Lys Leu Ser Ser Ala Val 
145                 150                 155                 160 


Val Phe Gly Gly Gly Glu Ala Arg Leu Ile Thr Glu Glu Asn Glu Glu 
                165                 170                 175     


Glu His Asn Phe Phe Leu Ala Pro Gly Thr Cys Val Val Asp Thr Gly 
            180                 185                 190         


Ile Thr Asn Ser Gln Thr Leu Ile Pro Asp Cys Gln Lys Lys Trp Ile 
        195                 200                 205             


Gln Ser Ile Met Asp Met Leu Gln Arg Gln Gly Leu Arg Pro Ile Pro 
    210                 215                 220                 


Glu Ala Glu Ile Gly Leu Ala Val Ile Phe Met Thr Thr Lys Asn Tyr 
225                 230                 235                 240 


Cys Asp Pro Gln Gly His Pro Ser Thr Gly Leu Lys Thr Thr Thr Pro 
                245                 250                 255     


Gly Pro Ser Leu Ser Gln Gly Val Ser Val Asp Glu Lys Leu Met Pro 
            260                 265                 270         


Ser Ala Pro Val Asn Thr Thr Thr Tyr Val Ala Asp Thr Glu Ser Glu 
        275                 280                 285             


Gln Ala Asp Thr Trp Asp Leu Ser Glu Arg Pro Lys Glu Ile Lys Val 
    290                 295                 300                 


Ser Lys Met Glu Gln Lys Phe Arg Met Leu Ser Gln Asp Ala Pro Thr 
305                 310                 315                 320 


Val Lys Glu Ser Cys Lys Thr Ser Ser Asn Asn Asn Ser Met Val Ser 
                325                 330                 335     


Asn Thr Leu Ala Lys Met Arg Ile Pro Asn Tyr Gln Leu Ser Pro Thr 
            340                 345                 350         


Lys Leu Pro Ser Ile Asn Lys Ser Lys Asp Arg Ala Ser Gln Gln Gln 
        355                 360                 365             


Gln Thr Asn Ser Ile Arg Asn Tyr Phe Gln Pro Ser Thr Lys Lys Arg 
    370                 375                 380                 


Glu Arg Asp Glu Glu Asn Gln Glu Met Ser Ser Cys Lys Ser Ala Arg 
385                 390                 395                 400 


Ile Glu Thr Ser Cys Ser Leu Leu Glu Gln Thr Gln Pro Ala Thr Pro 
                405                 410                 415     


Ser Leu Trp Lys Asn Lys Glu Gln His Leu Ser Glu Asn Glu Pro Val 
            420                 425                 430         


Asp Thr Asn Ser Asp Asn Asn Leu Phe Thr Asp Thr Asp Leu Lys Ser 
        435                 440                 445             


Ile Val Lys Asn Ser Ala Ser Lys Ser His Ala Ala Glu Lys Leu Arg 
    450                 455                 460                 


Ser Asn Lys Lys Arg Glu Met Asp Asp Val Ala Ile Glu Asp Glu Val 
465                 470                 475                 480 


Leu Glu Gln Leu Phe Lys Asp Thr Lys Pro Glu Leu Glu Ile Asp Val 
                485                 490                 495     


Lys Val Gln Lys Gln Glu Glu Asp Val Asn Val Arg Lys Arg Pro Arg 
            500                 505                 510         


Met Asp Ile Glu Thr Asn Asp Thr Phe Ser Asp Glu Ala Val Pro Glu 
        515                 520                 525             


Ser Ser Lys Ile Ser Gln Glu Asn Glu Ile Gly Lys Lys Arg Glu Leu 
    530                 535                 540                 


Lys Glu Asp Ser Leu Trp Ser Ala Lys Glu Ile Ser Asn Asn Asp Lys 
545                 550                 555                 560 


Leu Gln Asp Asp Ser Glu Met Leu Pro Lys Lys Leu Leu Leu Thr Glu 
                565                 570                 575     


Phe Arg Ser Leu Val Ile Lys Asn Ser Thr Ser Arg Asn Pro Ser Gly 
            580                 585                 590         


Ile Asn Asp Asp Tyr Gly Gln Leu Lys Asn Phe Lys Lys Phe Lys Lys 
        595                 600                 605             


Val Thr Tyr Pro Gly Ala Gly Lys Leu Pro His Ile Ile Gly Gly Ser 
    610                 615                 620                 


Asp Leu Ile Ala His His Ala Arg Lys Asn Thr Glu Leu Glu Glu Trp 
625                 630                 635                 640 


Leu Arg Gln Glu Met Glu Val Gln Asn Gln His Ala Lys Glu Glu Ser 
                645                 650                 655     


Leu Ala Asp Asp Leu Phe Arg Tyr Asn Pro Tyr Leu Lys Arg Arg Arg 
            660                 665                 670         


<210>  19
<211>  469
<212>  PRT
<213>  homo sapiens

<400>  19

Met Trp Lys Leu Leu Pro Ala Ala Gly Pro Ala Gly Gly Glu Pro Tyr 
1               5                   10                  15      


Arg Leu Leu Thr Gly Val Glu Tyr Val Val Gly Arg Lys Asn Cys Ala 
            20                  25                  30          


Ile Leu Ile Glu Asn Asp Gln Ser Ile Ser Arg Asn His Ala Val Leu 
        35                  40                  45              


Thr Ala Asn Phe Ser Val Thr Asn Leu Ser Gln Thr Asp Glu Ile Pro 
    50                  55                  60                  


Val Leu Thr Leu Lys Asp Asn Ser Lys Tyr Gly Thr Phe Val Asn Glu 
65                  70                  75                  80  


Glu Lys Met Gln Asn Gly Phe Ser Arg Thr Leu Lys Ser Gly Asp Gly 
                85                  90                  95      


Ile Thr Phe Gly Val Phe Gly Ser Lys Phe Arg Ile Glu Tyr Glu Pro 
            100                 105                 110         


Leu Val Ala Cys Ser Ser Cys Leu Asp Val Ser Gly Lys Thr Ala Leu 
        115                 120                 125             


Asn Gln Ala Ile Leu Gln Leu Gly Gly Phe Thr Val Asn Asn Trp Thr 
    130                 135                 140                 


Glu Glu Cys Thr His Leu Val Met Val Ser Val Lys Val Thr Ile Lys 
145                 150                 155                 160 


Thr Ile Cys Ala Leu Ile Cys Gly Arg Pro Ile Val Lys Pro Glu Tyr 
                165                 170                 175     


Phe Thr Glu Phe Leu Lys Ala Val Glu Ser Lys Lys Gln Pro Pro Gln 
            180                 185                 190         


Ile Glu Ser Phe Tyr Pro Pro Leu Asp Glu Pro Ser Ile Gly Ser Lys 
        195                 200                 205             


Asn Val Asp Leu Ser Gly Arg Gln Glu Arg Lys Gln Ile Phe Lys Gly 
    210                 215                 220                 


Lys Thr Phe Ile Phe Leu Asn Ala Lys Gln His Lys Lys Leu Ser Ser 
225                 230                 235                 240 


Ala Val Val Phe Gly Gly Gly Glu Ala Arg Leu Ile Thr Glu Glu Asn 
                245                 250                 255     


Glu Glu Glu His Asn Phe Phe Leu Ala Pro Gly Thr Cys Val Val Asp 
            260                 265                 270         


Thr Gly Ile Thr Asn Ser Gln Thr Leu Ile Pro Asp Cys Gln Lys Lys 
        275                 280                 285             


Trp Ile Gln Ser Ile Met Asp Met Leu Gln Arg Gln Gly Leu Arg Pro 
    290                 295                 300                 


Ile Pro Glu Ala Glu Ile Gly Leu Ala Val Ile Phe Met Thr Thr Lys 
305                 310                 315                 320 


Asn Tyr Cys Asp Pro Gln Gly His Pro Ser Thr Gly Leu Lys Thr Thr 
                325                 330                 335     


Thr Pro Gly Pro Ser Leu Ser Gln Gly Val Ser Val Asp Glu Lys Leu 
            340                 345                 350         


Met Pro Ser Ala Pro Val Asn Thr Thr Thr Tyr Val Ala Asp Thr Glu 
        355                 360                 365             


Ser Glu Gln Ala Asp Thr Trp Asp Leu Ser Glu Arg Pro Lys Glu Ile 
    370                 375                 380                 


Lys Val Ser Lys Met Glu Gln Lys Phe Arg Met Leu Ser Gln Asp Ala 
385                 390                 395                 400 


Pro Thr Val Lys Glu Ser Cys Lys Thr Ser Ser Asn Asn Asn Ser Met 
                405                 410                 415     


Val Ser Asn Thr Leu Ala Lys Met Arg Ile Pro Asn Tyr Gln Leu Ser 
            420                 425                 430         


Pro Thr Lys Leu Pro Ser Ile Asn Lys Ser Lys Asp Arg Ala Ser Gln 
        435                 440                 445             


Gln Gln Gln Thr Asn Ser Ile Arg Asn Tyr Phe Gln Pro Ser Thr Lys 
    450                 455                 460                 


Lys Lys Gly Lys Gly 
465                 


<210>  20
<211>  461
<212>  PRT
<213>  homo sapiens

<400>  20

Met Asp Met Leu Gln Arg Gln Gly Leu Arg Pro Ile Pro Glu Ala Glu 
1               5                   10                  15      


Ile Gly Leu Ala Val Ile Phe Met Thr Thr Lys Asn Tyr Cys Asp Pro 
            20                  25                  30          


Gln Gly His Pro Ser Thr Gly Leu Lys Thr Thr Thr Pro Gly Pro Ser 
        35                  40                  45              


Leu Ser Gln Gly Val Ser Val Asp Glu Lys Leu Met Pro Ser Ala Pro 
    50                  55                  60                  


Val Asn Thr Thr Thr Tyr Val Ala Asp Thr Glu Ser Glu Gln Ala Asp 
65                  70                  75                  80  


Thr Trp Asp Leu Ser Glu Arg Pro Lys Glu Ile Lys Val Ser Lys Met 
                85                  90                  95      


Glu Gln Lys Phe Arg Met Leu Ser Gln Asp Ala Pro Thr Val Lys Glu 
            100                 105                 110         


Ser Cys Lys Thr Ser Ser Asn Asn Asn Ser Met Val Ser Asn Thr Leu 
        115                 120                 125             


Ala Lys Met Arg Ile Pro Asn Tyr Gln Leu Ser Pro Thr Lys Leu Pro 
    130                 135                 140                 


Ser Ile Asn Lys Ser Lys Asp Arg Ala Ser Gln Gln Gln Gln Thr Asn 
145                 150                 155                 160 


Ser Ile Arg Asn Tyr Phe Gln Pro Ser Thr Lys Lys Arg Glu Arg Asp 
                165                 170                 175     


Glu Glu Asn Gln Glu Met Ser Ser Cys Lys Ser Ala Arg Ile Glu Thr 
            180                 185                 190         


Ser Cys Ser Leu Leu Glu Gln Thr Gln Pro Ala Thr Pro Ser Leu Trp 
        195                 200                 205             


Lys Asn Lys Glu Gln His Leu Ser Glu Asn Glu Pro Val Asp Thr Asn 
    210                 215                 220                 


Ser Asp Asn Asn Leu Phe Thr Asp Thr Asp Leu Lys Ser Ile Val Lys 
225                 230                 235                 240 


Asn Ser Ala Ser Lys Ser His Ala Ala Glu Lys Leu Arg Ser Asn Lys 
                245                 250                 255     


Lys Arg Glu Met Asp Asp Val Ala Ile Glu Asp Glu Val Leu Glu Gln 
            260                 265                 270         


Leu Phe Lys Asp Thr Lys Pro Glu Leu Glu Ile Asp Val Lys Val Gln 
        275                 280                 285             


Lys Gln Glu Glu Asp Val Asn Val Arg Lys Arg Pro Arg Met Asp Ile 
    290                 295                 300                 


Glu Thr Asn Asp Thr Phe Ser Asp Glu Ala Val Pro Glu Ser Ser Lys 
305                 310                 315                 320 


Ile Ser Gln Glu Asn Glu Ile Gly Lys Lys Arg Glu Leu Lys Glu Asp 
                325                 330                 335     


Ser Leu Trp Ser Ala Lys Glu Ile Ser Asn Asn Asp Lys Leu Gln Asp 
            340                 345                 350         


Asp Ser Glu Met Leu Pro Lys Lys Leu Leu Leu Thr Glu Phe Arg Ser 
        355                 360                 365             


Leu Val Ile Lys Asn Ser Thr Ser Arg Asn Pro Ser Gly Ile Asn Asp 
    370                 375                 380                 


Asp Tyr Gly Gln Leu Lys Asn Phe Lys Lys Phe Lys Lys Val Thr Tyr 
385                 390                 395                 400 


Pro Gly Ala Gly Lys Leu Pro His Ile Ile Gly Gly Ser Asp Leu Ile 
                405                 410                 415     


Ala His His Ala Arg Lys Asn Thr Glu Leu Glu Glu Trp Leu Arg Gln 
            420                 425                 430         


Glu Met Glu Val Gln Asn Gln His Ala Lys Glu Glu Ser Leu Ala Asp 
        435                 440                 445             


Asp Leu Phe Arg Tyr Asn Pro Tyr Leu Lys Arg Arg Arg 
    450                 455                 460     


<210>  21
<211>  1417
<212>  PRT
<213>  homo sapiens

<400>  21

Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Gly  Ser Lys Ser Ala Lys  Ile Gln Ser 
    1115                 1120                 1125             


Gly Ile  Phe Gly Lys Gly Ser  Ala Tyr Ser Arg His  Asn Ala Glu 
    1130                 1135                 1140             


Arg Leu  Phe Lys Lys Leu Ile  Leu Asp Lys Ile Leu  Asp Glu Asp 
    1145                 1150                 1155             


Leu Tyr  Ile Asn Ala Asn Asp  Gln Ala Ile Ala Tyr  Val Met Leu 
    1160                 1165                 1170             


Gly Asn  Lys Ala Gln Thr Val  Leu Asn Gly Asn Leu  Lys Val Asp 
    1175                 1180                 1185             


Phe Met  Glu Thr Glu Asn Ser  Ser Ser Val Lys Lys  Gln Lys Ala 
    1190                 1195                 1200             


Leu Val  Ala Lys Val Ser Gln  Arg Glu Glu Met Val  Lys Lys Cys 
    1205                 1210                 1215             


Leu Gly  Glu Leu Thr Glu Val  Cys Lys Ser Leu Gly  Lys Val Phe 
    1220                 1225                 1230             


Gly Val  His Tyr Phe Asn Ile  Phe Asn Thr Val Thr  Leu Lys Lys 
    1235                 1240                 1245             


Leu Ala  Glu Ser Leu Ser Ser  Asp Pro Glu Val Leu  Leu Gln Ile 
    1250                 1255                 1260             


Asp Gly  Val Thr Glu Asp Lys  Leu Glu Lys Tyr Gly  Ala Glu Val 
    1265                 1270                 1275             


Ile Ser  Val Leu Gln Lys Tyr  Ser Glu Trp Thr Ser  Pro Ala Glu 
    1280                 1285                 1290             


Asp Ser  Ser Pro Gly Ile Ser  Leu Ser Ser Ser Arg  Gly Pro Gly 
    1295                 1300                 1305             


Arg Ser  Ala Ala Glu Glu Leu  Asp Glu Glu Ile Pro  Val Ser Ser 
    1310                 1315                 1320             


His Tyr  Phe Ala Ser Lys Thr  Arg Asn Glu Arg Lys  Arg Lys Lys 
    1325                 1330                 1335             


Met Pro  Ala Ser Gln Arg Ser  Lys Arg Arg Lys Thr  Ala Ser Ser 
    1340                 1345                 1350             


Gly Ser  Lys Ala Lys Gly Gly  Ser Ala Thr Cys Arg  Lys Ile Ser 
    1355                 1360                 1365             


Ser Lys  Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
    1370                 1375                 1380             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1385                 1390                 1395             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1400                 1405                 1410             


Tyr Ala  Phe Ser 
    1415         


<210>  22
<211>  1286
<212>  PRT
<213>  homo sapiens

<400>  22

Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Glu  Ser Leu Ser Ser Asp  Pro Glu Val 
    1115                 1120                 1125             


Leu Leu  Gln Ile Asp Gly Val  Thr Glu Asp Lys Leu  Glu Lys Tyr 
    1130                 1135                 1140             


Gly Ala  Glu Val Ile Ser Val  Leu Gln Lys Tyr Ser  Glu Trp Thr 
    1145                 1150                 1155             


Ser Pro  Ala Glu Asp Ser Ser  Pro Gly Ile Ser Leu  Ser Ser Ser 
    1160                 1165                 1170             


Arg Gly  Pro Gly Arg Ser Ala  Ala Glu Glu Leu Asp  Glu Glu Ile 
    1175                 1180                 1185             


Pro Val  Ser Ser His Tyr Phe  Ala Ser Lys Thr Arg  Asn Glu Arg 
    1190                 1195                 1200             


Lys Arg  Lys Lys Met Pro Ala  Ser Gln Arg Ser Lys  Arg Arg Lys 
    1205                 1210                 1215             


Thr Ala  Ser Ser Gly Ser Lys  Ala Lys Gly Gly Ser  Ala Thr Cys 
    1220                 1225                 1230             


Arg Lys  Ile Ser Ser Lys Thr  Lys Ser Ser Ser Ile  Ile Gly Ser 
    1235                 1240                 1245             


Ser Ser  Ala Ser His Thr Ser  Gln Ala Thr Ser Gly  Ala Asn Ser 
    1250                 1255                 1260             


Lys Leu  Gly Ile Met Ala Pro  Pro Lys Pro Ile Asn  Arg Pro Phe 
    1265                 1270                 1275             


Leu Lys  Pro Ser Tyr Ala Phe  Ser 
    1280                 1285     


<210>  23
<211>  1042
<212>  PRT
<213>  homo sapiens

<400>  23

Met Glu His Ile Cys Lys Leu Ile Asp Thr Ile Pro Asp Asp Lys Leu 
1               5                   10                  15      


Lys Leu Leu Asp Cys Gly Asn Glu Leu Leu Gln Gln Arg Asn Ile Arg 
            20                  25                  30          


Arg Lys Leu Leu Thr Glu Val Asp Phe Asn Lys Ser Asp Ala Ser Leu 
        35                  40                  45              


Leu Gly Ser Leu Trp Arg Tyr Arg Pro Asp Ser Leu Asp Gly Pro Met 
    50                  55                  60                  


Glu Gly Asp Ser Cys Pro Thr Gly Asn Ser Met Lys Glu Leu Asn Phe 
65                  70                  75                  80  


Ser His Leu Pro Ser Asn Ser Val Ser Pro Gly Asp Cys Leu Leu Thr 
                85                  90                  95      


Thr Thr Leu Gly Lys Thr Gly Phe Ser Ala Thr Arg Lys Asn Leu Phe 
            100                 105                 110         


Glu Arg Pro Leu Phe Asn Thr His Leu Gln Lys Ser Phe Val Ser Ser 
        115                 120                 125             


Asn Trp Ala Glu Thr Pro Arg Leu Gly Lys Lys Asn Glu Ser Ser Tyr 
    130                 135                 140                 


Phe Pro Gly Asn Val Leu Thr Ser Thr Ala Val Lys Asp Gln Asn Lys 
145                 150                 155                 160 


His Thr Ala Ser Ile Asn Asp Leu Glu Arg Glu Thr Gln Pro Ser Tyr 
                165                 170                 175     


Asp Ile Asp Asn Phe Asp Ile Asp Asp Phe Asp Asp Asp Asp Asp Trp 
            180                 185                 190         


Glu Asp Ile Met His Asn Leu Ala Ala Ser Lys Ser Ser Thr Ala Ala 
        195                 200                 205             


Tyr Gln Pro Ile Lys Glu Gly Arg Pro Ile Lys Ser Val Ser Glu Arg 
    210                 215                 220                 


Leu Ser Ser Ala Lys Thr Asp Cys Leu Pro Val Ser Ser Thr Ala Gln 
225                 230                 235                 240 


Asn Ile Asn Phe Ser Glu Ser Ile Gln Asn Tyr Thr Asp Lys Ser Ala 
                245                 250                 255     


Gln Asn Leu Ala Ser Arg Asn Leu Lys His Glu Arg Phe Gln Ser Leu 
            260                 265                 270         


Ser Phe Pro His Thr Lys Glu Met Met Lys Ile Phe His Lys Lys Phe 
        275                 280                 285             


Gly Leu His Asn Phe Arg Thr Asn Gln Leu Glu Ala Ile Asn Ala Ala 
    290                 295                 300                 


Leu Leu Gly Glu Asp Cys Phe Ile Leu Met Pro Thr Gly Gly Gly Lys 
305                 310                 315                 320 


Ser Leu Cys Tyr Gln Leu Pro Ala Cys Val Ser Pro Gly Val Thr Val 
                325                 330                 335     


Val Ile Ser Pro Leu Arg Ser Leu Ile Val Asp Gln Val Gln Lys Leu 
            340                 345                 350         


Thr Ser Leu Asp Ile Pro Ala Thr Tyr Leu Thr Gly Asp Lys Thr Asp 
        355                 360                 365             


Ser Glu Ala Thr Asn Ile Tyr Leu Gln Leu Ser Lys Lys Asp Pro Ile 
    370                 375                 380                 


Ile Lys Leu Leu Tyr Val Thr Pro Glu Lys Ile Cys Ala Ser Asn Arg 
385                 390                 395                 400 


Leu Ile Ser Thr Leu Glu Asn Leu Tyr Glu Arg Lys Leu Leu Ala Arg 
                405                 410                 415     


Phe Val Ile Asp Glu Ala His Cys Val Ser Gln Trp Gly His Asp Phe 
            420                 425                 430         


Arg Gln Asp Tyr Lys Arg Met Asn Met Leu Arg Gln Lys Phe Pro Ser 
        435                 440                 445             


Val Pro Val Met Ala Leu Thr Ala Thr Ala Asn Pro Arg Val Gln Lys 
    450                 455                 460                 


Asp Ile Leu Thr Gln Leu Lys Ile Leu Arg Pro Gln Val Phe Ser Met 
465                 470                 475                 480 


Ser Phe Asn Arg His Asn Leu Lys Tyr Tyr Val Leu Pro Lys Lys Pro 
                485                 490                 495     


Lys Lys Val Ala Phe Asp Cys Leu Glu Trp Ile Arg Lys His His Pro 
            500                 505                 510         


Tyr Asp Ser Gly Ile Ile Tyr Cys Leu Ser Arg Arg Glu Cys Asp Thr 
        515                 520                 525             


Met Ala Asp Thr Leu Gln Arg Asp Gly Leu Ala Ala Leu Ala Tyr His 
    530                 535                 540                 


Ala Gly Leu Ser Asp Ser Ala Arg Asp Glu Val Gln Gln Lys Trp Ile 
545                 550                 555                 560 


Asn Gln Asp Gly Cys Gln Val Ile Cys Ala Thr Ile Ala Phe Gly Met 
                565                 570                 575     


Gly Ile Asp Lys Pro Asp Val Arg Phe Val Ile His Ala Ser Leu Pro 
            580                 585                 590         


Lys Ser Val Glu Gly Tyr Tyr Gln Glu Ser Gly Arg Ala Gly Arg Asp 
        595                 600                 605             


Gly Glu Ile Ser His Cys Leu Leu Phe Tyr Thr Tyr His Asp Val Thr 
    610                 615                 620                 


Arg Leu Lys Arg Leu Ile Met Met Glu Lys Asp Gly Asn His His Thr 
625                 630                 635                 640 


Arg Glu Thr His Phe Asn Asn Leu Tyr Ser Met Val His Tyr Cys Glu 
                645                 650                 655     


Asn Ile Thr Glu Cys Arg Arg Ile Gln Leu Leu Ala Tyr Phe Gly Glu 
            660                 665                 670         


Asn Gly Phe Asn Pro Asp Phe Cys Lys Lys His Pro Asp Val Ser Cys 
        675                 680                 685             


Asp Asn Cys Cys Lys Thr Lys Asp Tyr Lys Thr Arg Asp Val Thr Asp 
    690                 695                 700                 


Asp Val Lys Ser Ile Val Arg Phe Val Gln Glu His Ser Ser Ser Gln 
705                 710                 715                 720 


Gly Met Arg Asn Ile Lys His Val Gly Pro Ser Gly Arg Phe Thr Met 
                725                 730                 735     


Asn Met Leu Val Asp Ile Phe Leu Gly Ser Lys Ser Ala Lys Ile Gln 
            740                 745                 750         


Ser Gly Ile Phe Gly Lys Gly Ser Ala Tyr Ser Arg His Asn Ala Glu 
        755                 760                 765             


Arg Leu Phe Lys Lys Leu Ile Leu Asp Lys Ile Leu Asp Glu Asp Leu 
    770                 775                 780                 


Tyr Ile Asn Ala Asn Asp Gln Ala Ile Ala Tyr Val Met Leu Gly Asn 
785                 790                 795                 800 


Lys Ala Gln Thr Val Leu Asn Gly Asn Leu Lys Val Asp Phe Met Glu 
                805                 810                 815     


Thr Glu Asn Ser Ser Ser Val Lys Lys Gln Lys Ala Leu Val Ala Lys 
            820                 825                 830         


Val Ser Gln Arg Glu Glu Met Val Lys Lys Cys Leu Gly Glu Leu Thr 
        835                 840                 845             


Glu Val Cys Lys Ser Leu Gly Lys Val Phe Gly Val His Tyr Phe Asn 
    850                 855                 860                 


Ile Phe Asn Thr Val Thr Leu Lys Lys Leu Ala Glu Ser Leu Ser Ser 
865                 870                 875                 880 


Asp Pro Glu Val Leu Leu Gln Ile Asp Gly Val Thr Glu Asp Lys Leu 
                885                 890                 895     


Glu Lys Tyr Gly Ala Glu Val Ile Ser Val Leu Gln Lys Tyr Ser Glu 
            900                 905                 910         


Trp Thr Ser Pro Ala Glu Asp Ser Ser Pro Gly Ile Ser Leu Ser Ser 
        915                 920                 925             


Ser Arg Gly Pro Gly Arg Ser Ala Ala Glu Glu Leu Asp Glu Glu Ile 
    930                 935                 940                 


Pro Val Ser Ser His Tyr Phe Ala Ser Lys Thr Arg Asn Glu Arg Lys 
945                 950                 955                 960 


Arg Lys Lys Met Pro Ala Ser Gln Arg Ser Lys Arg Arg Lys Thr Ala 
                965                 970                 975     


Ser Ser Gly Ser Lys Ala Lys Gly Gly Ser Ala Thr Cys Arg Lys Ile 
            980                 985                 990         


Ser Ser Lys Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
        995                 1000                 1005             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1010                 1015                 1020             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1025                 1030                 1035             


Tyr Ala  Phe Ser 
    1040         


<210>  24
<211>  763
<212>  PRT
<213>  homo sapiens

<400>  24

Met Met Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr 
1               5                   10                  15      


Asn Gln Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe 
            20                  25                  30          


Ile Leu Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro 
        35                  40                  45              


Ala Cys Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser 
    50                  55                  60                  


Leu Ile Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala 
65                  70                  75                  80  


Thr Tyr Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr 
                85                  90                  95      


Leu Gln Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr 
            100                 105                 110         


Pro Glu Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn 
        115                 120                 125             


Leu Tyr Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His 
    130                 135                 140                 


Cys Val Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met 
145                 150                 155                 160 


Asn Met Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr 
                165                 170                 175     


Ala Thr Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys 
            180                 185                 190         


Ile Leu Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu 
        195                 200                 205             


Lys Tyr Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys 
    210                 215                 220                 


Leu Glu Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr 
225                 230                 235                 240 


Cys Leu Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg 
                245                 250                 255     


Asp Gly Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala 
            260                 265                 270         


Arg Asp Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val 
        275                 280                 285             


Ile Cys Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val 
    290                 295                 300                 


Arg Phe Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr 
305                 310                 315                 320 


Gln Glu Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu 
                325                 330                 335     


Leu Phe Tyr Thr Tyr His Asp Val Thr Arg Leu Lys Arg Leu Ile Met 
            340                 345                 350         


Met Glu Lys Asp Gly Asn His His Thr Arg Glu Thr His Phe Asn Asn 
        355                 360                 365             


Leu Tyr Ser Met Val His Tyr Cys Glu Asn Ile Thr Glu Cys Arg Arg 
    370                 375                 380                 


Ile Gln Leu Leu Ala Tyr Phe Gly Glu Asn Gly Phe Asn Pro Asp Phe 
385                 390                 395                 400 


Cys Lys Lys His Pro Asp Val Ser Cys Asp Asn Cys Cys Lys Thr Lys 
                405                 410                 415     


Asp Tyr Lys Thr Arg Asp Val Thr Asp Asp Val Lys Ser Ile Val Arg 
            420                 425                 430         


Phe Val Gln Glu His Ser Ser Ser Gln Gly Met Arg Asn Ile Lys His 
        435                 440                 445             


Val Gly Pro Ser Gly Arg Phe Thr Met Asn Met Leu Val Asp Ile Phe 
    450                 455                 460                 


Leu Gly Ser Lys Ser Ala Lys Ile Gln Ser Gly Ile Phe Gly Lys Gly 
465                 470                 475                 480 


Ser Ala Tyr Ser Arg His Asn Ala Glu Arg Leu Phe Lys Lys Leu Ile 
                485                 490                 495     


Leu Asp Lys Ile Leu Asp Glu Asp Leu Tyr Ile Asn Ala Asn Asp Gln 
            500                 505                 510         


Ala Ile Ala Tyr Val Met Leu Gly Asn Lys Ala Gln Thr Val Leu Asn 
        515                 520                 525             


Gly Asn Leu Lys Val Asp Phe Met Glu Thr Glu Asn Ser Ser Ser Val 
    530                 535                 540                 


Lys Lys Gln Lys Ala Leu Val Ala Lys Val Ser Gln Arg Glu Glu Met 
545                 550                 555                 560 


Val Lys Lys Cys Leu Gly Glu Leu Thr Glu Val Cys Lys Ser Leu Gly 
                565                 570                 575     


Lys Val Phe Gly Val His Tyr Phe Asn Ile Phe Asn Thr Val Thr Leu 
            580                 585                 590         


Lys Lys Leu Ala Glu Ser Leu Ser Ser Asp Pro Glu Val Leu Leu Gln 
        595                 600                 605             


Ile Asp Gly Val Thr Glu Asp Lys Leu Glu Lys Tyr Gly Ala Glu Val 
    610                 615                 620                 


Ile Ser Val Leu Gln Lys Tyr Ser Glu Trp Thr Ser Pro Ala Glu Asp 
625                 630                 635                 640 


Ser Ser Pro Gly Ile Ser Leu Ser Ser Ser Arg Gly Pro Gly Arg Ser 
                645                 650                 655     


Ala Ala Glu Glu Leu Asp Glu Glu Ile Pro Val Ser Ser His Tyr Phe 
            660                 665                 670         


Ala Ser Lys Thr Arg Asn Glu Arg Lys Arg Lys Lys Met Pro Ala Ser 
        675                 680                 685             


Gln Arg Ser Lys Arg Arg Lys Thr Ala Ser Ser Gly Ser Lys Ala Lys 
    690                 695                 700                 


Gly Gly Ser Ala Thr Cys Arg Lys Ile Ser Ser Lys Thr Lys Ser Ser 
705                 710                 715                 720 


Ser Ile Ile Gly Ser Ser Ser Ala Ser His Thr Ser Gln Ala Thr Ser 
                725                 730                 735     


Gly Ala Asn Ser Lys Leu Gly Ile Met Ala Pro Pro Lys Pro Ile Asn 
            740                 745                 750         


Arg Pro Phe Leu Lys Pro Ser Tyr Ala Phe Ser 
        755                 760             


<210>  25
<211>  979
<212>  PRT
<213>  homo sapiens

<400>  25

Met Glu Gly Asp Ser Cys Pro Thr Gly Asn Ser Met Lys Glu Leu Asn 
1               5                   10                  15      


Phe Ser His Leu Pro Ser Asn Ser Val Ser Pro Gly Asp Cys Leu Leu 
            20                  25                  30          


Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser Ala Thr Arg Lys Asn Leu 
        35                  40                  45              


Phe Glu Arg Pro Leu Phe Asn Thr His Leu Gln Lys Ser Phe Val Ser 
    50                  55                  60                  


Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly Lys Lys Asn Glu Ser Ser 
65                  70                  75                  80  


Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr Ala Val Lys Asp Gln Asn 
                85                  90                  95      


Lys His Thr Ala Ser Ile Asn Asp Leu Glu Arg Glu Thr Gln Pro Ser 
            100                 105                 110         


Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp Phe Asp Asp Asp Asp Asp 
        115                 120                 125             


Trp Glu Asp Ile Met His Asn Leu Ala Ala Ser Lys Ser Ser Thr Ala 
    130                 135                 140                 


Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro Ile Lys Ser Val Ser Glu 
145                 150                 155                 160 


Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu Pro Val Ser Ser Thr Ala 
                165                 170                 175     


Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln Asn Tyr Thr Asp Lys Ser 
            180                 185                 190         


Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys His Glu Arg Phe Gln Ser 
        195                 200                 205             


Leu Ser Phe Pro His Thr Lys Glu Met Met Lys Ile Phe His Lys Lys 
    210                 215                 220                 


Phe Gly Leu His Asn Phe Arg Thr Asn Gln Leu Glu Ala Ile Asn Ala 
225                 230                 235                 240 


Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu Met Pro Thr Gly Gly Gly 
                245                 250                 255     


Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys Val Ser Pro Gly Val Thr 
            260                 265                 270         


Val Val Ile Ser Pro Leu Arg Ser Leu Ile Val Asp Gln Val Gln Lys 
        275                 280                 285             


Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr Leu Thr Gly Asp Lys Thr 
    290                 295                 300                 


Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln Leu Ser Lys Lys Asp Pro 
305                 310                 315                 320 


Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu Lys Ile Cys Ala Ser Asn 
                325                 330                 335     


Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr Glu Arg Lys Leu Leu Ala 
            340                 345                 350         


Arg Phe Val Ile Asp Glu Ala His Cys Val Ser Gln Trp Gly His Asp 
        355                 360                 365             


Phe Arg Gln Asp Tyr Lys Arg Met Asn Met Leu Arg Gln Lys Phe Pro 
    370                 375                 380                 


Ser Val Pro Val Met Ala Leu Thr Ala Thr Ala Asn Pro Arg Val Gln 
385                 390                 395                 400 


Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu Arg Pro Gln Val Phe Ser 
                405                 410                 415     


Met Ser Phe Asn Arg His Asn Leu Lys Tyr Tyr Val Leu Pro Lys Lys 
            420                 425                 430         


Pro Lys Lys Val Ala Phe Asp Cys Leu Glu Trp Ile Arg Lys His His 
        435                 440                 445             


Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu Ser Arg Arg Glu Cys Asp 
    450                 455                 460                 


Thr Met Ala Asp Thr Leu Gln Arg Asp Gly Leu Ala Ala Leu Ala Tyr 
465                 470                 475                 480 


His Ala Gly Leu Ser Asp Ser Ala Arg Asp Glu Val Gln Gln Lys Trp 
                485                 490                 495     


Ile Asn Gln Asp Gly Cys Gln Val Ile Cys Ala Thr Ile Ala Phe Gly 
            500                 505                 510         


Met Gly Ile Asp Lys Pro Asp Val Arg Phe Val Ile His Ala Ser Leu 
        515                 520                 525             


Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu Ser Gly Arg Ala Gly Arg 
    530                 535                 540                 


Asp Gly Glu Ile Ser His Cys Leu Leu Phe Tyr Thr Tyr His Asp Val 
545                 550                 555                 560 


Thr Arg Leu Lys Arg Leu Ile Met Met Glu Lys Asp Gly Asn His His 
                565                 570                 575     


Thr Arg Glu Thr His Phe Asn Asn Leu Tyr Ser Met Val His Tyr Cys 
            580                 585                 590         


Glu Asn Ile Thr Glu Cys Arg Arg Ile Gln Leu Leu Ala Tyr Phe Gly 
        595                 600                 605             


Glu Asn Gly Phe Asn Pro Asp Phe Cys Lys Lys His Pro Asp Val Ser 
    610                 615                 620                 


Cys Asp Asn Cys Cys Lys Thr Lys Asp Tyr Lys Thr Arg Asp Val Thr 
625                 630                 635                 640 


Asp Asp Val Lys Ser Ile Val Arg Phe Val Gln Glu His Ser Ser Ser 
                645                 650                 655     


Gln Gly Met Arg Asn Ile Lys His Val Gly Pro Ser Gly Arg Phe Thr 
            660                 665                 670         


Met Asn Met Leu Val Asp Ile Phe Leu Gly Ser Lys Ser Ala Lys Ile 
        675                 680                 685             


Gln Ser Gly Ile Phe Gly Lys Gly Ser Ala Tyr Ser Arg His Asn Ala 
    690                 695                 700                 


Glu Arg Leu Phe Lys Lys Leu Ile Leu Asp Lys Ile Leu Asp Glu Asp 
705                 710                 715                 720 


Leu Tyr Ile Asn Ala Asn Asp Gln Ala Ile Ala Tyr Val Met Leu Gly 
                725                 730                 735     


Asn Lys Ala Gln Thr Val Leu Asn Gly Asn Leu Lys Val Asp Phe Met 
            740                 745                 750         


Glu Thr Glu Asn Ser Ser Ser Val Lys Lys Gln Lys Ala Leu Val Ala 
        755                 760                 765             


Lys Val Ser Gln Arg Glu Glu Met Val Lys Lys Cys Leu Gly Glu Leu 
    770                 775                 780                 


Thr Glu Val Cys Lys Ser Leu Gly Lys Val Phe Gly Val His Tyr Phe 
785                 790                 795                 800 


Asn Ile Phe Asn Thr Val Thr Leu Lys Lys Leu Ala Glu Ser Leu Ser 
                805                 810                 815     


Ser Asp Pro Glu Val Leu Leu Gln Ile Asp Gly Val Thr Glu Asp Lys 
            820                 825                 830         


Leu Glu Lys Tyr Gly Ala Glu Val Ile Ser Val Leu Gln Lys Tyr Ser 
        835                 840                 845             


Glu Trp Thr Ser Pro Ala Glu Asp Ser Ser Pro Gly Ile Ser Leu Ser 
    850                 855                 860                 


Ser Ser Arg Gly Pro Gly Arg Ser Ala Ala Glu Glu Leu Asp Glu Glu 
865                 870                 875                 880 


Ile Pro Val Ser Ser His Tyr Phe Ala Ser Lys Thr Arg Asn Glu Arg 
                885                 890                 895     


Lys Arg Lys Lys Met Pro Ala Ser Gln Arg Ser Lys Arg Arg Lys Thr 
            900                 905                 910         


Ala Ser Ser Gly Ser Lys Ala Lys Gly Gly Ser Ala Thr Cys Arg Lys 
        915                 920                 925             


Ile Ser Ser Lys Thr Lys Ser Ser Ser Ile Ile Gly Ser Ser Ser Ala 
    930                 935                 940                 


Ser His Thr Ser Gln Ala Thr Ser Gly Ala Asn Ser Lys Leu Gly Ile 
945                 950                 955                 960 


Met Ala Pro Pro Lys Pro Ile Asn Arg Pro Phe Leu Lys Pro Ser Tyr 
                965                 970                 975     


Ala Phe Ser 
            


<210>  26
<211>  907
<212>  PRT
<213>  homo sapiens

<400>  26

Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Ile Val Gln Pro Ser Pro Ile Ser Lys Phe Thr Ala 
    850                 855                 860                 


Phe Leu Ser Pro Gln Arg Glu Thr Trp Tyr Pro Leu Ala Ala Ala Pro 
865                 870                 875                 880 


His Leu Leu Pro Leu Val Cys Ala Arg Leu Leu Ser Leu Ser Val Val 
                885                 890                 895     


Phe Lys Gly His Pro Cys Cys Ser Ile Gly Gln 
            900                 905         


<210>  27
<211>  846
<212>  PRT
<213>  homo sapiens

<400>  27

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro 
                805                 810                 815     


Val Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe 
            820                 825                 830         


Asn Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845     


<210>  28
<211>  845
<212>  PRT
<213>  homo sapiens

<400>  28

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Glu Leu Ser Glu Asp Asp Leu Leu Ser Gln 
            420                 425                 430         


Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu Gly 
        435                 440                 445             


Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val Asn 
    450                 455                 460                 


Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg Asn 
465                 470                 475                 480 


Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala Val 
                485                 490                 495     


Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser Thr 
            500                 505                 510         


Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr Ala 
        515                 520                 525             


Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp Gln 
    530                 535                 540                 


Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser Asp 
545                 550                 555                 560 


Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys Ala 
                565                 570                 575     


Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys Phe 
            580                 585                 590         


Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys Phe 
        595                 600                 605             


Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro Ser 
    610                 615                 620                 


Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro Thr 
625                 630                 635                 640 


Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser Glu 
                645                 650                 655     


Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys Ser 
            660                 665                 670         


Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn Ala 
        675                 680                 685             


Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu Ser 
    690                 695                 700                 


Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser Lys 
705                 710                 715                 720 


Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn Lys 
                725                 730                 735     


Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr Thr 
            740                 745                 750         


Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys Lys 
        755                 760                 765             


Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys Pro 
    770                 775                 780                 


Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe Lys 
785                 790                 795                 800 


Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro Val 
                805                 810                 815     


Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe Asn 
            820                 825                 830         


Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845 


<210>  29
<211>  806
<212>  PRT
<213>  homo sapiens

<400>  29

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Arg Arg Gln Ala Asn Leu Leu Lys Gly Lys 
    50                  55                  60                  


Gln Leu Leu Arg Glu Gly Lys Val Ser Glu Ala Arg Glu Cys Phe Thr 
65                  70                  75                  80  


Arg Ser Ile Asn Ile Thr His Ala Met Ala His Lys Val Ile Lys Ala 
                85                  90                  95      


Ala Arg Ser Gln Gly Val Asp Cys Leu Val Ala Pro Tyr Glu Ala Asp 
            100                 105                 110         


Ala Gln Leu Ala Tyr Leu Asn Lys Ala Gly Ile Val Gln Ala Ile Ile 
        115                 120                 125             


Thr Glu Asp Ser Asp Leu Leu Ala Phe Gly Cys Lys Lys Val Ile Leu 
    130                 135                 140                 


Lys Met Asp Gln Phe Gly Asn Gly Leu Glu Ile Asp Gln Ala Arg Leu 
145                 150                 155                 160 


Gly Met Cys Arg Gln Leu Gly Asp Val Phe Thr Glu Glu Lys Phe Arg 
                165                 170                 175     


Tyr Met Cys Ile Leu Ser Gly Cys Asp Tyr Leu Ser Ser Leu Arg Gly 
            180                 185                 190         


Ile Gly Leu Ala Lys Ala Cys Lys Val Leu Arg Leu Ala Asn Asn Pro 
        195                 200                 205             


Asp Ile Val Lys Val Ile Lys Lys Ile Gly His Tyr Leu Lys Met Asn 
    210                 215                 220                 


Ile Thr Val Pro Glu Asp Tyr Ile Asn Gly Phe Ile Arg Ala Asn Asn 
225                 230                 235                 240 


Thr Phe Leu Tyr Gln Leu Val Phe Asp Pro Ile Lys Arg Lys Leu Ile 
                245                 250                 255     


Pro Leu Asn Ala Tyr Glu Asp Asp Val Asp Pro Glu Thr Leu Ser Tyr 
            260                 265                 270         


Ala Gly Gln Tyr Val Asp Asp Ser Ile Ala Leu Gln Ile Ala Leu Gly 
        275                 280                 285             


Asn Lys Asp Ile Asn Thr Phe Glu Gln Ile Asp Asp Tyr Asn Pro Asp 
    290                 295                 300                 


Thr Ala Met Pro Ala His Ser Arg Ser His Ser Trp Asp Asp Lys Thr 
305                 310                 315                 320 


Cys Gln Lys Ser Ala Asn Val Ser Ser Ile Trp His Arg Asn Tyr Ser 
                325                 330                 335     


Pro Arg Pro Glu Ser Gly Thr Val Ser Asp Ala Pro Gln Leu Lys Glu 
            340                 345                 350         


Asn Pro Ser Thr Val Gly Val Glu Arg Val Ile Ser Thr Lys Gly Leu 
        355                 360                 365             


Asn Leu Pro Arg Lys Ser Ser Ile Val Lys Arg Pro Arg Ser Ala Glu 
    370                 375                 380                 


Leu Ser Glu Asp Asp Leu Leu Ser Gln Tyr Ser Leu Ser Phe Thr Lys 
385                 390                 395                 400 


Lys Thr Lys Lys Asn Ser Ser Glu Gly Asn Lys Ser Leu Ser Phe Ser 
                405                 410                 415     


Glu Val Phe Val Pro Asp Leu Val Asn Gly Pro Thr Asn Lys Lys Ser 
            420                 425                 430         


Val Ser Thr Pro Pro Arg Thr Arg Asn Lys Phe Ala Thr Phe Leu Gln 
        435                 440                 445             


Arg Lys Asn Glu Glu Ser Gly Ala Val Val Val Pro Gly Thr Arg Ser 
    450                 455                 460                 


Arg Phe Phe Cys Ser Ser Asp Ser Thr Asp Cys Val Ser Asn Lys Val 
465                 470                 475                 480 


Ser Ile Gln Pro Leu Asp Glu Thr Ala Val Thr Asp Lys Glu Asn Asn 
                485                 490                 495     


Leu His Glu Ser Glu Tyr Gly Asp Gln Glu Gly Lys Arg Leu Val Asp 
            500                 505                 510         


Thr Asp Val Ala Arg Asn Ser Ser Asp Asp Ile Pro Asn Asn His Ile 
        515                 520                 525             


Pro Gly Asp His Ile Pro Asp Lys Ala Thr Val Phe Thr Asp Glu Glu 
    530                 535                 540                 


Ser Tyr Ser Phe Glu Ser Ser Lys Phe Thr Arg Thr Ile Ser Pro Pro 
545                 550                 555                 560 


Thr Leu Gly Thr Leu Arg Ser Cys Phe Ser Trp Ser Gly Gly Leu Gly 
                565                 570                 575     


Asp Phe Ser Arg Thr Pro Ser Pro Ser Pro Ser Thr Ala Leu Gln Gln 
            580                 585                 590         


Phe Arg Arg Lys Ser Asp Ser Pro Thr Ser Leu Pro Glu Asn Asn Met 
        595                 600                 605             


Ser Asp Val Ser Gln Leu Lys Ser Glu Glu Ser Ser Asp Asp Glu Ser 
    610                 615                 620                 


His Pro Leu Arg Glu Glu Ala Cys Ser Ser Gln Ser Gln Glu Ser Gly 
625                 630                 635                 640 


Glu Phe Ser Leu Gln Ser Ser Asn Ala Ser Lys Leu Ser Gln Cys Ser 
                645                 650                 655     


Ser Lys Asp Ser Asp Ser Glu Glu Ser Asp Cys Asn Ile Lys Leu Leu 
            660                 665                 670         


Asp Ser Gln Ser Asp Gln Thr Ser Lys Leu Arg Leu Ser His Phe Ser 
        675                 680                 685             


Lys Lys Asp Thr Pro Leu Arg Asn Lys Val Pro Gly Leu Tyr Lys Ser 
    690                 695                 700                 


Ser Ser Ala Asp Ser Leu Ser Thr Thr Lys Ile Lys Pro Leu Gly Pro 
705                 710                 715                 720 


Ala Arg Ala Ser Gly Leu Ser Lys Lys Pro Ala Ser Ile Gln Lys Arg 
                725                 730                 735     


Lys His His Asn Ala Glu Asn Lys Pro Gly Leu Gln Ile Lys Leu Asn 
            740                 745                 750         


Glu Leu Trp Lys Asn Phe Gly Phe Lys Lys Asp Ser Glu Lys Leu Pro 
        755                 760                 765             


Pro Cys Lys Lys Pro Leu Ser Pro Val Arg Asp Asn Ile Gln Leu Thr 
    770                 775                 780                 


Pro Glu Ala Glu Glu Asp Ile Phe Asn Lys Pro Glu Cys Gly Arg Val 
785                 790                 795                 800 


Gln Arg Ala Ile Phe Gln 
                805     


<210>  30
<211>  525
<212>  PRT
<213>  homo sapiens

<400>  30

Met Glu Lys Tyr Arg Thr Ser Lys Val Gly Asn Val Ile Gln Gly Gln 
1               5                   10                  15      


Leu Phe His Gln Gln Leu Leu Phe Leu Arg Pro Ala His Ser Arg Ser 
            20                  25                  30          


His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser Ser 
        35                  40                  45              


Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val Ser 
    50                  55                  60                  


Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu Arg 
65                  70                  75                  80  


Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile Val 
                85                  90                  95      


Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser Gln 
            100                 105                 110         


Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu Gly 
        115                 120                 125             


Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val Asn 
    130                 135                 140                 


Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg Asn 
145                 150                 155                 160 


Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala Val 
                165                 170                 175     


Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser Thr 
            180                 185                 190         


Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr Ala 
        195                 200                 205             


Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp Gln 
    210                 215                 220                 


Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser Asp 
225                 230                 235                 240 


Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys Ala 
                245                 250                 255     


Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys Phe 
            260                 265                 270         


Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys Phe 
        275                 280                 285             


Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro Ser 
    290                 295                 300                 


Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro Thr 
305                 310                 315                 320 


Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser Glu 
                325                 330                 335     


Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys Ser 
            340                 345                 350         


Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn Ala 
        355                 360                 365             


Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu Ser 
    370                 375                 380                 


Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser Lys 
385                 390                 395                 400 


Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn Lys 
                405                 410                 415     


Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr Thr 
            420                 425                 430         


Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys Lys 
        435                 440                 445             


Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys Pro 
    450                 455                 460                 


Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe Lys 
465                 470                 475                 480 


Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro Val 
                485                 490                 495     


Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe Asn 
            500                 505                 510         


Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        515                 520                 525 


<210>  31
<211>  803
<212>  PRT
<213>  homo sapiens

<400>  31

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Phe 
            


<210>  32
<211>  846
<212>  PRT
<213>  homo sapiens

<400>  32

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro 
                805                 810                 815     


Val Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe 
            820                 825                 830         


Asn Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845     


<210>  33
<211>  845
<212>  PRT
<213>  homo sapiens

<400>  33

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Glu Leu Ser Glu Asp Asp Leu Leu Ser Gln 
            420                 425                 430         


Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu Gly 
        435                 440                 445             


Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val Asn 
    450                 455                 460                 


Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg Asn 
465                 470                 475                 480 


Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala Val 
                485                 490                 495     


Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser Thr 
            500                 505                 510         


Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr Ala 
        515                 520                 525             


Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp Gln 
    530                 535                 540                 


Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser Asp 
545                 550                 555                 560 


Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys Ala 
                565                 570                 575     


Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys Phe 
            580                 585                 590         


Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys Phe 
        595                 600                 605             


Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro Ser 
    610                 615                 620                 


Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro Thr 
625                 630                 635                 640 


Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser Glu 
                645                 650                 655     


Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys Ser 
            660                 665                 670         


Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn Ala 
        675                 680                 685             


Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu Ser 
    690                 695                 700                 


Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser Lys 
705                 710                 715                 720 


Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn Lys 
                725                 730                 735     


Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr Thr 
            740                 745                 750         


Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys Lys 
        755                 760                 765             


Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys Pro 
    770                 775                 780                 


Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe Lys 
785                 790                 795                 800 


Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro Val 
                805                 810                 815     


Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe Asn 
            820                 825                 830         


Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845 


<210>  34
<211>  1060
<212>  PRT
<213>  homo sapiens

<400>  34

Met Glu Gln Leu Asn Glu Leu Glu Leu Leu Met Glu Lys Ser Phe Trp 
1               5                   10                  15      


Glu Glu Ala Glu Leu Pro Ala Glu Leu Phe Gln Lys Lys Val Val Ala 
            20                  25                  30          


Ser Phe Pro Arg Thr Val Leu Ser Thr Gly Met Asp Asn Arg Tyr Leu 
        35                  40                  45              


Val Leu Ala Val Asn Thr Val Gln Asn Lys Glu Gly Asn Cys Glu Lys 
    50                  55                  60                  


Arg Leu Val Ile Thr Ala Ser Gln Ser Leu Glu Asn Lys Glu Leu Cys 
65                  70                  75                  80  


Ile Leu Arg Asn Asp Trp Cys Ser Val Pro Val Glu Pro Gly Asp Ile 
                85                  90                  95      


Ile His Leu Glu Gly Asp Cys Thr Ser Asp Thr Trp Ile Ile Asp Lys 
            100                 105                 110         


Asp Phe Gly Tyr Leu Ile Leu Tyr Pro Asp Met Leu Ile Ser Gly Thr 
        115                 120                 125             


Ser Ile Ala Ser Ser Ile Arg Cys Met Arg Arg Ala Val Leu Ser Glu 
    130                 135                 140                 


Thr Phe Arg Ser Ser Asp Pro Ala Thr Arg Gln Met Leu Ile Gly Thr 
145                 150                 155                 160 


Val Leu His Glu Val Phe Gln Lys Ala Ile Asn Asn Ser Phe Ala Pro 
                165                 170                 175     


Glu Lys Leu Gln Glu Leu Ala Phe Gln Thr Ile Gln Glu Ile Arg His 
            180                 185                 190         


Leu Lys Glu Met Tyr Arg Leu Asn Leu Ser Gln Asp Glu Ile Lys Gln 
        195                 200                 205             


Glu Val Glu Asp Tyr Leu Pro Ser Phe Cys Lys Trp Ala Gly Asp Phe 
    210                 215                 220                 


Met His Lys Asn Thr Ser Thr Asp Phe Pro Gln Met Gln Leu Ser Leu 
225                 230                 235                 240 


Pro Ser Asp Asn Ser Lys Asp Asn Ser Thr Cys Asn Ile Glu Val Val 
                245                 250                 255     


Lys Pro Met Asp Ile Glu Glu Ser Ile Trp Ser Pro Arg Phe Gly Leu 
            260                 265                 270         


Lys Gly Lys Ile Asp Val Thr Val Gly Val Lys Ile His Arg Gly Tyr 
        275                 280                 285             


Lys Thr Lys Tyr Lys Ile Met Pro Leu Glu Leu Lys Thr Gly Lys Glu 
    290                 295                 300                 


Ser Asn Ser Ile Glu His Arg Ser Gln Val Val Leu Tyr Thr Leu Leu 
305                 310                 315                 320 


Ser Gln Glu Arg Arg Ala Asp Pro Glu Ala Gly Leu Leu Leu Tyr Leu 
                325                 330                 335     


Lys Thr Gly Gln Met Tyr Pro Val Pro Ala Asn His Leu Asp Lys Arg 
            340                 345                 350         


Glu Leu Leu Lys Leu Arg Asn Gln Met Ala Phe Ser Leu Phe His Arg 
        355                 360                 365             


Ile Ser Lys Ser Ala Thr Arg Gln Lys Thr Gln Leu Ala Ser Leu Pro 
    370                 375                 380                 


Gln Ile Ile Glu Glu Glu Lys Thr Cys Lys Tyr Cys Ser Gln Ile Gly 
385                 390                 395                 400 


Asn Cys Ala Leu Tyr Ser Arg Ala Val Glu Gln Gln Met Asp Cys Ser 
                405                 410                 415     


Ser Val Pro Ile Val Met Leu Pro Lys Ile Glu Glu Glu Thr Gln His 
            420                 425                 430         


Leu Lys Gln Thr His Leu Glu Tyr Phe Ser Leu Trp Cys Leu Met Leu 
        435                 440                 445             


Thr Leu Glu Ser Gln Ser Lys Asp Asn Lys Lys Asn His Gln Asn Ile 
    450                 455                 460                 


Trp Leu Met Pro Ala Ser Glu Met Glu Lys Ser Gly Ser Cys Ile Gly 
465                 470                 475                 480 


Asn Leu Ile Arg Met Glu His Val Lys Ile Val Cys Asp Gly Gln Tyr 
                485                 490                 495     


Leu His Asn Phe Gln Cys Lys His Gly Ala Ile Pro Val Thr Asn Leu 
            500                 505                 510         


Met Ala Gly Asp Arg Val Ile Val Ser Gly Glu Glu Arg Ser Leu Phe 
        515                 520                 525             


Ala Leu Ser Arg Gly Tyr Val Lys Glu Ile Asn Met Thr Thr Val Thr 
    530                 535                 540                 


Cys Leu Leu Asp Arg Asn Leu Ser Val Leu Pro Glu Ser Thr Leu Phe 
545                 550                 555                 560 


Arg Leu Asp Gln Glu Glu Lys Asn Cys Asp Ile Asp Thr Pro Leu Gly 
                565                 570                 575     


Asn Leu Ser Lys Leu Met Glu Asn Thr Phe Val Ser Lys Lys Leu Arg 
            580                 585                 590         


Asp Leu Ile Ile Asp Phe Arg Glu Pro Gln Phe Ile Ser Tyr Leu Ser 
        595                 600                 605             


Ser Val Leu Pro His Asp Ala Lys Asp Thr Val Ala Cys Ile Leu Lys 
    610                 615                 620                 


Gly Leu Asn Lys Pro Gln Arg Gln Ala Met Lys Lys Val Leu Leu Ser 
625                 630                 635                 640 


Lys Asp Tyr Thr Leu Ile Val Gly Met Pro Gly Thr Gly Lys Thr Thr 
                645                 650                 655     


Thr Ile Cys Thr Leu Val Arg Ile Leu Tyr Ala Cys Gly Phe Ser Val 
            660                 665                 670         


Leu Leu Thr Ser Tyr Thr His Ser Ala Val Asp Asn Ile Leu Leu Lys 
        675                 680                 685             


Leu Ala Lys Phe Lys Ile Gly Phe Leu Arg Leu Gly Gln Ile Gln Lys 
    690                 695                 700                 


Val His Pro Ala Ile Gln Gln Phe Thr Glu Gln Glu Ile Cys Arg Ser 
705                 710                 715                 720 


Lys Ser Ile Lys Ser Leu Ala Leu Leu Glu Glu Leu Tyr Asn Ser Gln 
                725                 730                 735     


Leu Ile Val Ala Thr Thr Cys Met Gly Ile Asn His Pro Ile Phe Ser 
            740                 745                 750         


Arg Lys Ile Phe Asp Phe Cys Ile Val Asp Glu Ala Ser Gln Ile Ser 
        755                 760                 765             


Gln Pro Ile Cys Leu Gly Pro Leu Phe Phe Ser Arg Arg Phe Val Leu 
    770                 775                 780                 


Val Gly Asp His Gln Gln Leu Pro Pro Leu Val Leu Asn Arg Glu Ala 
785                 790                 795                 800 


Arg Ala Leu Gly Met Ser Glu Ser Leu Phe Lys Arg Leu Glu Gln Asn 
                805                 810                 815     


Lys Ser Ala Val Val Gln Leu Thr Val Gln Tyr Arg Met Asn Ser Lys 
            820                 825                 830         


Ile Met Ser Leu Ser Asn Lys Leu Thr Tyr Glu Gly Lys Leu Glu Cys 
        835                 840                 845             


Gly Ser Asp Lys Val Ala Asn Ala Val Ile Asn Leu Arg His Phe Lys 
    850                 855                 860                 


Asp Val Lys Leu Glu Leu Glu Phe Tyr Ala Asp Tyr Ser Asp Asn Pro 
865                 870                 875                 880 


Trp Leu Met Gly Val Phe Glu Pro Asn Asn Pro Val Cys Phe Leu Asn 
                885                 890                 895     


Thr Asp Lys Val Pro Ala Pro Glu Gln Val Glu Lys Gly Gly Val Ser 
            900                 905                 910         


Asn Val Thr Glu Ala Lys Leu Ile Val Phe Leu Thr Ser Ile Phe Val 
        915                 920                 925             


Lys Ala Gly Cys Ser Pro Ser Asp Ile Gly Ile Ile Ala Pro Tyr Arg 
    930                 935                 940                 


Gln Gln Leu Lys Ile Ile Asn Asp Leu Leu Ala Arg Ser Ile Gly Met 
945                 950                 955                 960 


Val Glu Val Asn Thr Val Asp Lys Tyr Gln Gly Arg Asp Lys Ser Ile 
                965                 970                 975     


Val Leu Val Ser Phe Val Arg Ser Asn Lys Asp Gly Thr Val Gly Glu 
            980                 985                 990         


Leu Leu Lys Asp Trp Arg Arg Leu  Asn Val Ala Ile Thr  Arg Ala Lys 
        995                 1000                 1005             


His Lys  Leu Ile Leu Leu Gly  Cys Val Pro Ser Leu  Asn Cys Tyr 
    1010                 1015                 1020             


Pro Pro  Leu Glu Lys Leu Leu  Asn His Leu Asn Ser  Glu Lys Leu 
    1025                 1030                 1035             


Ile Ile  Asp Leu Pro Ser Arg  Glu His Glu Ser Leu  Cys His Ile 
    1040                 1045                 1050             


Leu Gly  Asp Phe Gln Arg Glu  
    1055                 1060 


<210>  35
<211>  1090
<212>  PRT
<213>  homo sapiens

<400>  35

Met Lys Thr Pro Cys Ile Pro Ser Pro Lys Gln Gly Ser Lys Gly Arg 
1               5                   10                  15      


Gly Gln Ser Pro Ala Ala Gln Phe Ala Ile Pro Ala Ser Arg Met Glu 
            20                  25                  30          


Gln Leu Asn Glu Leu Glu Leu Leu Met Glu Lys Ser Phe Trp Glu Glu 
        35                  40                  45              


Ala Glu Leu Pro Ala Glu Leu Phe Gln Lys Lys Val Val Ala Ser Phe 
    50                  55                  60                  


Pro Arg Thr Val Leu Ser Thr Gly Met Asp Asn Arg Tyr Leu Val Leu 
65                  70                  75                  80  


Ala Val Asn Thr Val Gln Asn Lys Glu Gly Asn Cys Glu Lys Arg Leu 
                85                  90                  95      


Val Ile Thr Ala Ser Gln Ser Leu Glu Asn Lys Glu Leu Cys Ile Leu 
            100                 105                 110         


Arg Asn Asp Trp Cys Ser Val Pro Val Glu Pro Gly Asp Ile Ile His 
        115                 120                 125             


Leu Glu Gly Asp Cys Thr Ser Asp Thr Trp Ile Ile Asp Lys Asp Phe 
    130                 135                 140                 


Gly Tyr Leu Ile Leu Tyr Pro Asp Met Leu Ile Ser Gly Thr Ser Ile 
145                 150                 155                 160 


Ala Ser Ser Ile Arg Cys Met Arg Arg Ala Val Leu Ser Glu Thr Phe 
                165                 170                 175     


Arg Ser Ser Asp Pro Ala Thr Arg Gln Met Leu Ile Gly Thr Val Leu 
            180                 185                 190         


His Glu Val Phe Gln Lys Ala Ile Asn Asn Ser Phe Ala Pro Glu Lys 
        195                 200                 205             


Leu Gln Glu Leu Ala Phe Gln Thr Ile Gln Glu Ile Arg His Leu Lys 
    210                 215                 220                 


Glu Met Tyr Arg Leu Asn Leu Ser Gln Asp Glu Ile Lys Gln Glu Val 
225                 230                 235                 240 


Glu Asp Tyr Leu Pro Ser Phe Cys Lys Trp Ala Gly Asp Phe Met His 
                245                 250                 255     


Lys Asn Thr Ser Thr Asp Phe Pro Gln Met Gln Leu Ser Leu Pro Ser 
            260                 265                 270         


Asp Asn Ser Lys Asp Asn Ser Thr Cys Asn Ile Glu Val Val Lys Pro 
        275                 280                 285             


Met Asp Ile Glu Glu Ser Ile Trp Ser Pro Arg Phe Gly Leu Lys Gly 
    290                 295                 300                 


Lys Ile Asp Val Thr Val Gly Val Lys Ile His Arg Gly Tyr Lys Thr 
305                 310                 315                 320 


Lys Tyr Lys Ile Met Pro Leu Glu Leu Lys Thr Gly Lys Glu Ser Asn 
                325                 330                 335     


Ser Ile Glu His Arg Ser Gln Val Val Leu Tyr Thr Leu Leu Ser Gln 
            340                 345                 350         


Glu Arg Arg Ala Asp Pro Glu Ala Gly Leu Leu Leu Tyr Leu Lys Thr 
        355                 360                 365             


Gly Gln Met Tyr Pro Val Pro Ala Asn His Leu Asp Lys Arg Glu Leu 
    370                 375                 380                 


Leu Lys Leu Arg Asn Gln Met Ala Phe Ser Leu Phe His Arg Ile Ser 
385                 390                 395                 400 


Lys Ser Ala Thr Arg Gln Lys Thr Gln Leu Ala Ser Leu Pro Gln Ile 
                405                 410                 415     


Ile Glu Glu Glu Lys Thr Cys Lys Tyr Cys Ser Gln Ile Gly Asn Cys 
            420                 425                 430         


Ala Leu Tyr Ser Arg Ala Val Glu Gln Gln Met Asp Cys Ser Ser Val 
        435                 440                 445             


Pro Ile Val Met Leu Pro Lys Ile Glu Glu Glu Thr Gln His Leu Lys 
    450                 455                 460                 


Gln Thr His Leu Glu Tyr Phe Ser Leu Trp Cys Leu Met Leu Thr Leu 
465                 470                 475                 480 


Glu Ser Gln Ser Lys Asp Asn Lys Lys Asn His Gln Asn Ile Trp Leu 
                485                 490                 495     


Met Pro Ala Ser Glu Met Glu Lys Ser Gly Ser Cys Ile Gly Asn Leu 
            500                 505                 510         


Ile Arg Met Glu His Val Lys Ile Val Cys Asp Gly Gln Tyr Leu His 
        515                 520                 525             


Asn Phe Gln Cys Lys His Gly Ala Ile Pro Val Thr Asn Leu Met Ala 
    530                 535                 540                 


Gly Asp Arg Val Ile Val Ser Gly Glu Glu Arg Ser Leu Phe Ala Leu 
545                 550                 555                 560 


Ser Arg Gly Tyr Val Lys Glu Ile Asn Met Thr Thr Val Thr Cys Leu 
                565                 570                 575     


Leu Asp Arg Asn Leu Ser Val Leu Pro Glu Ser Thr Leu Phe Arg Leu 
            580                 585                 590         


Asp Gln Glu Glu Lys Asn Cys Asp Ile Asp Thr Pro Leu Gly Asn Leu 
        595                 600                 605             


Ser Lys Leu Met Glu Asn Thr Phe Val Ser Lys Lys Leu Arg Asp Leu 
    610                 615                 620                 


Ile Ile Asp Phe Arg Glu Pro Gln Phe Ile Ser Tyr Leu Ser Ser Val 
625                 630                 635                 640 


Leu Pro His Asp Ala Lys Asp Thr Val Ala Cys Ile Leu Lys Gly Leu 
                645                 650                 655     


Asn Lys Pro Gln Arg Gln Ala Met Lys Lys Val Leu Leu Ser Lys Asp 
            660                 665                 670         


Tyr Thr Leu Ile Val Gly Met Pro Gly Thr Gly Lys Thr Thr Thr Ile 
        675                 680                 685             


Cys Thr Leu Val Arg Ile Leu Tyr Ala Cys Gly Phe Ser Val Leu Leu 
    690                 695                 700                 


Thr Ser Tyr Thr His Ser Ala Val Asp Asn Ile Leu Leu Lys Leu Ala 
705                 710                 715                 720 


Lys Phe Lys Ile Gly Phe Leu Arg Leu Gly Gln Ile Gln Lys Val His 
                725                 730                 735     


Pro Ala Ile Gln Gln Phe Thr Glu Gln Glu Ile Cys Arg Ser Lys Ser 
            740                 745                 750         


Ile Lys Ser Leu Ala Leu Leu Glu Glu Leu Tyr Asn Ser Gln Leu Ile 
        755                 760                 765             


Val Ala Thr Thr Cys Met Gly Ile Asn His Pro Ile Phe Ser Arg Lys 
    770                 775                 780                 


Ile Phe Asp Phe Cys Ile Val Asp Glu Ala Ser Gln Ile Ser Gln Pro 
785                 790                 795                 800 


Ile Cys Leu Gly Pro Leu Phe Phe Ser Arg Arg Phe Val Leu Val Gly 
                805                 810                 815     


Asp His Gln Gln Leu Pro Pro Leu Val Leu Asn Arg Glu Ala Arg Ala 
            820                 825                 830         


Leu Gly Met Ser Glu Ser Leu Phe Lys Arg Leu Glu Gln Asn Lys Ser 
        835                 840                 845             


Ala Val Val Gln Leu Thr Val Gln Tyr Arg Met Asn Ser Lys Ile Met 
    850                 855                 860                 


Ser Leu Ser Asn Lys Leu Thr Tyr Glu Gly Lys Leu Glu Cys Gly Ser 
865                 870                 875                 880 


Asp Lys Val Ala Asn Ala Val Ile Asn Leu Arg His Phe Lys Asp Val 
                885                 890                 895     


Lys Leu Glu Leu Glu Phe Tyr Ala Asp Tyr Ser Asp Asn Pro Trp Leu 
            900                 905                 910         


Met Gly Val Phe Glu Pro Asn Asn Pro Val Cys Phe Leu Asn Thr Asp 
        915                 920                 925             


Lys Val Pro Ala Pro Glu Gln Val Glu Lys Gly Gly Val Ser Asn Val 
    930                 935                 940                 


Thr Glu Ala Lys Leu Ile Val Phe Leu Thr Ser Ile Phe Val Lys Ala 
945                 950                 955                 960 


Gly Cys Ser Pro Ser Asp Ile Gly Ile Ile Ala Pro Tyr Arg Gln Gln 
                965                 970                 975     


Leu Lys Ile Ile Asn Asp Leu Leu Ala Arg Ser Ile Gly Met Val Glu 
            980                 985                 990         


Val Asn Thr Val Asp Lys Tyr Gln  Gly Arg Asp Lys Ser  Ile Val Leu 
        995                 1000                 1005             


Val Ser  Phe Val Arg Ser Asn  Lys Asp Gly Thr Val  Gly Glu Leu 
    1010                 1015                 1020             


Leu Lys  Asp Trp Arg Arg Leu  Asn Val Ala Ile Thr  Arg Ala Lys 
    1025                 1030                 1035             


His Lys  Leu Ile Leu Leu Gly  Cys Val Pro Ser Leu  Asn Cys Tyr 
    1040                 1045                 1050             


Pro Pro  Leu Glu Lys Leu Leu  Asn His Leu Asn Ser  Glu Lys Leu 
    1055                 1060                 1065             


Ile Ile  Asp Leu Pro Ser Arg  Glu His Glu Ser Leu  Cys His Ile 
    1070                 1075                 1080             


Leu Gly  Asp Phe Gln Arg Glu  
    1085                 1090 


<210>  36
<211>  700
<212>  PRT
<213>  homo sapiens

<400>  36

Met Ala Phe Ser Leu Phe His Arg Ile Ser Lys Ser Ala Thr Arg Gln 
1               5                   10                  15      


Lys Thr Gln Leu Ala Ser Leu Pro Gln Ile Ile Glu Glu Glu Lys Thr 
            20                  25                  30          


Cys Lys Tyr Cys Ser Gln Ile Gly Asn Cys Ala Leu Tyr Ser Arg Ala 
        35                  40                  45              


Val Glu Gln Gln Met Asp Cys Ser Ser Val Pro Ile Val Met Leu Pro 
    50                  55                  60                  


Lys Ile Glu Glu Glu Thr Gln His Leu Lys Gln Thr His Leu Glu Tyr 
65                  70                  75                  80  


Phe Ser Leu Trp Cys Leu Met Leu Thr Leu Glu Ser Gln Ser Lys Asp 
                85                  90                  95      


Asn Lys Lys Asn His Gln Asn Ile Trp Leu Met Pro Ala Ser Glu Met 
            100                 105                 110         


Glu Lys Ser Gly Ser Cys Ile Gly Asn Leu Ile Arg Met Glu His Val 
        115                 120                 125             


Lys Ile Val Cys Asp Gly Gln Tyr Leu His Asn Phe Gln Cys Lys His 
    130                 135                 140                 


Gly Ala Ile Pro Val Thr Asn Leu Met Ala Gly Asp Arg Val Ile Val 
145                 150                 155                 160 


Ser Gly Glu Glu Arg Ser Leu Phe Ala Leu Ser Arg Gly Tyr Val Lys 
                165                 170                 175     


Glu Ile Asn Met Thr Thr Val Thr Cys Leu Leu Asp Arg Asn Leu Ser 
            180                 185                 190         


Val Leu Pro Glu Ser Thr Leu Phe Arg Leu Asp Gln Glu Glu Lys Asn 
        195                 200                 205             


Cys Asp Ile Asp Thr Pro Leu Gly Asn Leu Ser Lys Leu Met Glu Asn 
    210                 215                 220                 


Thr Phe Val Ser Lys Lys Leu Arg Asp Leu Ile Ile Asp Phe Arg Glu 
225                 230                 235                 240 


Pro Gln Phe Ile Ser Tyr Leu Ser Ser Val Leu Pro His Asp Ala Lys 
                245                 250                 255     


Asp Thr Val Ala Cys Ile Leu Lys Gly Leu Asn Lys Pro Gln Arg Gln 
            260                 265                 270         


Ala Met Lys Lys Val Leu Leu Ser Lys Asp Tyr Thr Leu Ile Val Gly 
        275                 280                 285             


Met Pro Gly Thr Gly Lys Thr Thr Thr Ile Cys Thr Leu Val Arg Ile 
    290                 295                 300                 


Leu Tyr Ala Cys Gly Phe Ser Val Leu Leu Thr Ser Tyr Thr His Ser 
305                 310                 315                 320 


Ala Val Asp Asn Ile Leu Leu Lys Leu Ala Lys Phe Lys Ile Gly Phe 
                325                 330                 335     


Leu Arg Leu Gly Gln Ile Gln Lys Val His Pro Ala Ile Gln Gln Phe 
            340                 345                 350         


Thr Glu Gln Glu Ile Cys Arg Ser Lys Ser Ile Lys Ser Leu Ala Leu 
        355                 360                 365             


Leu Glu Glu Leu Tyr Asn Ser Gln Leu Ile Val Ala Thr Thr Cys Met 
    370                 375                 380                 


Gly Ile Asn His Pro Ile Phe Ser Arg Lys Ile Phe Asp Phe Cys Ile 
385                 390                 395                 400 


Val Asp Glu Ala Ser Gln Ile Ser Gln Pro Ile Cys Leu Gly Pro Leu 
                405                 410                 415     


Phe Phe Ser Arg Arg Phe Val Leu Val Gly Asp His Gln Gln Leu Pro 
            420                 425                 430         


Pro Leu Val Leu Asn Arg Glu Ala Arg Ala Leu Gly Met Ser Glu Ser 
        435                 440                 445             


Leu Phe Lys Arg Leu Glu Gln Asn Lys Ser Ala Val Val Gln Leu Thr 
    450                 455                 460                 


Val Gln Tyr Arg Met Asn Ser Lys Ile Met Ser Leu Ser Asn Lys Leu 
465                 470                 475                 480 


Thr Tyr Glu Gly Lys Leu Glu Cys Gly Ser Asp Lys Val Ala Asn Ala 
                485                 490                 495     


Val Ile Asn Leu Arg His Phe Lys Asp Val Lys Leu Glu Leu Glu Phe 
            500                 505                 510         


Tyr Ala Asp Tyr Ser Asp Asn Pro Trp Leu Met Gly Val Phe Glu Pro 
        515                 520                 525             


Asn Asn Pro Val Cys Phe Leu Asn Thr Asp Lys Val Pro Ala Pro Glu 
    530                 535                 540                 


Gln Val Glu Lys Gly Gly Val Ser Asn Val Thr Glu Ala Lys Leu Ile 
545                 550                 555                 560 


Val Phe Leu Thr Ser Ile Phe Val Lys Ala Gly Cys Ser Pro Ser Asp 
                565                 570                 575     


Ile Gly Ile Ile Ala Pro Tyr Arg Gln Gln Leu Lys Ile Ile Asn Asp 
            580                 585                 590         


Leu Leu Ala Arg Ser Ile Gly Met Val Glu Val Asn Thr Val Asp Lys 
        595                 600                 605             


Tyr Gln Gly Arg Asp Lys Ser Ile Val Leu Val Ser Phe Val Arg Ser 
    610                 615                 620                 


Asn Lys Asp Gly Thr Val Gly Glu Leu Leu Lys Asp Trp Arg Arg Leu 
625                 630                 635                 640 


Asn Val Ala Ile Thr Arg Ala Lys His Lys Leu Ile Leu Leu Gly Cys 
                645                 650                 655     


Val Pro Ser Leu Asn Cys Tyr Pro Pro Leu Glu Lys Leu Leu Asn His 
            660                 665                 670         


Leu Asn Ser Glu Lys Leu Ile Ile Asp Leu Pro Ser Arg Glu His Glu 
        675                 680                 685             


Ser Leu Cys His Ile Leu Gly Asp Phe Gln Arg Glu 
    690                 695                 700 


<210>  37
<211>  836
<212>  PRT
<213>  homo sapiens

<400>  37

Met His Lys Asn Thr Ser Thr Asp Phe Pro Gln Met Gln Leu Ser Leu 
1               5                   10                  15      


Pro Ser Asp Asn Ser Lys Asp Asn Ser Thr Cys Asn Ile Glu Val Val 
            20                  25                  30          


Lys Pro Met Asp Ile Glu Glu Ser Ile Trp Ser Pro Arg Phe Gly Leu 
        35                  40                  45              


Lys Gly Lys Ile Asp Val Thr Val Gly Val Lys Ile His Arg Gly Tyr 
    50                  55                  60                  


Lys Thr Lys Tyr Lys Ile Met Pro Leu Glu Leu Lys Thr Gly Lys Glu 
65                  70                  75                  80  


Ser Asn Ser Ile Glu His Arg Ser Gln Val Val Leu Tyr Thr Leu Leu 
                85                  90                  95      


Ser Gln Glu Arg Arg Ala Asp Pro Glu Ala Gly Leu Leu Leu Tyr Leu 
            100                 105                 110         


Lys Thr Gly Gln Met Tyr Pro Val Pro Ala Asn His Leu Asp Lys Arg 
        115                 120                 125             


Glu Leu Leu Lys Leu Arg Asn Gln Met Ala Phe Ser Leu Phe His Arg 
    130                 135                 140                 


Ile Ser Lys Ser Ala Thr Arg Gln Lys Thr Gln Leu Ala Ser Leu Pro 
145                 150                 155                 160 


Gln Ile Ile Glu Glu Glu Lys Thr Cys Lys Tyr Cys Ser Gln Ile Gly 
                165                 170                 175     


Asn Cys Ala Leu Tyr Ser Arg Ala Val Glu Gln Gln Met Asp Cys Ser 
            180                 185                 190         


Ser Val Pro Ile Val Met Leu Pro Lys Ile Glu Glu Glu Thr Gln His 
        195                 200                 205             


Leu Lys Gln Thr His Leu Glu Tyr Phe Ser Leu Trp Cys Leu Met Leu 
    210                 215                 220                 


Thr Leu Glu Ser Gln Ser Lys Asp Asn Lys Lys Asn His Gln Asn Ile 
225                 230                 235                 240 


Trp Leu Met Pro Ala Ser Glu Met Glu Lys Ser Gly Ser Cys Ile Gly 
                245                 250                 255     


Asn Leu Ile Arg Met Glu His Val Lys Ile Val Cys Asp Gly Gln Tyr 
            260                 265                 270         


Leu His Asn Phe Gln Cys Lys His Gly Ala Ile Pro Val Thr Asn Leu 
        275                 280                 285             


Met Ala Gly Asp Arg Val Ile Val Ser Gly Glu Glu Arg Ser Leu Phe 
    290                 295                 300                 


Ala Leu Ser Arg Gly Tyr Val Lys Glu Ile Asn Met Thr Thr Val Thr 
305                 310                 315                 320 


Cys Leu Leu Asp Arg Asn Leu Ser Val Leu Pro Glu Ser Thr Leu Phe 
                325                 330                 335     


Arg Leu Asp Gln Glu Glu Lys Asn Cys Asp Ile Asp Thr Pro Leu Gly 
            340                 345                 350         


Asn Leu Ser Lys Leu Met Glu Asn Thr Phe Val Ser Lys Lys Leu Arg 
        355                 360                 365             


Asp Leu Ile Ile Asp Phe Arg Glu Pro Gln Phe Ile Ser Tyr Leu Ser 
    370                 375                 380                 


Ser Val Leu Pro His Asp Ala Lys Asp Thr Val Ala Cys Ile Leu Lys 
385                 390                 395                 400 


Gly Leu Asn Lys Pro Gln Arg Gln Ala Met Lys Lys Val Leu Leu Ser 
                405                 410                 415     


Lys Asp Tyr Thr Leu Ile Val Gly Met Pro Gly Thr Gly Lys Thr Thr 
            420                 425                 430         


Thr Ile Cys Thr Leu Val Arg Ile Leu Tyr Ala Cys Gly Phe Ser Val 
        435                 440                 445             


Leu Leu Thr Ser Tyr Thr His Ser Ala Val Asp Asn Ile Leu Leu Lys 
    450                 455                 460                 


Leu Ala Lys Phe Lys Ile Gly Phe Leu Arg Leu Gly Gln Ile Gln Lys 
465                 470                 475                 480 


Val His Pro Ala Ile Gln Gln Phe Thr Glu Gln Glu Ile Cys Arg Ser 
                485                 490                 495     


Lys Ser Ile Lys Ser Leu Ala Leu Leu Glu Glu Leu Tyr Asn Ser Gln 
            500                 505                 510         


Leu Ile Val Ala Thr Thr Cys Met Gly Ile Asn His Pro Ile Phe Ser 
        515                 520                 525             


Arg Lys Ile Phe Asp Phe Cys Ile Val Asp Glu Ala Ser Gln Ile Ser 
    530                 535                 540                 


Gln Pro Ile Cys Leu Gly Pro Leu Phe Phe Ser Arg Arg Phe Val Leu 
545                 550                 555                 560 


Val Gly Asp His Gln Gln Leu Pro Pro Leu Val Leu Asn Arg Glu Ala 
                565                 570                 575     


Arg Ala Leu Gly Met Ser Glu Ser Leu Phe Lys Arg Leu Glu Gln Asn 
            580                 585                 590         


Lys Ser Ala Val Val Gln Leu Thr Val Gln Tyr Arg Met Asn Ser Lys 
        595                 600                 605             


Ile Met Ser Leu Ser Asn Lys Leu Thr Tyr Glu Gly Lys Leu Glu Cys 
    610                 615                 620                 


Gly Ser Asp Lys Val Ala Asn Ala Val Ile Asn Leu Arg His Phe Lys 
625                 630                 635                 640 


Asp Val Lys Leu Glu Leu Glu Phe Tyr Ala Asp Tyr Ser Asp Asn Pro 
                645                 650                 655     


Trp Leu Met Gly Val Phe Glu Pro Asn Asn Pro Val Cys Phe Leu Asn 
            660                 665                 670         


Thr Asp Lys Val Pro Ala Pro Glu Gln Val Glu Lys Gly Gly Val Ser 
        675                 680                 685             


Asn Val Thr Glu Ala Lys Leu Ile Val Phe Leu Thr Ser Ile Phe Val 
    690                 695                 700                 


Lys Ala Gly Cys Ser Pro Ser Asp Ile Gly Ile Ile Ala Pro Tyr Arg 
705                 710                 715                 720 


Gln Gln Leu Lys Ile Ile Asn Asp Leu Leu Ala Arg Ser Ile Gly Met 
                725                 730                 735     


Val Glu Val Asn Thr Val Asp Lys Tyr Gln Gly Arg Asp Lys Ser Ile 
            740                 745                 750         


Val Leu Val Ser Phe Val Arg Ser Asn Lys Asp Gly Thr Val Gly Glu 
        755                 760                 765             


Leu Leu Lys Asp Trp Arg Arg Leu Asn Val Ala Ile Thr Arg Ala Lys 
    770                 775                 780                 


His Lys Leu Ile Leu Leu Gly Cys Val Pro Ser Leu Asn Cys Tyr Pro 
785                 790                 795                 800 


Pro Leu Glu Lys Leu Leu Asn His Leu Asn Ser Glu Lys Leu Ile Ile 
                805                 810                 815     


Asp Leu Pro Ser Arg Glu His Glu Ser Leu Cys His Ile Leu Gly Asp 
            820                 825                 830         


Phe Gln Arg Glu 
        835     


<210>  38
<211>  916
<212>  PRT
<213>  homo sapiens

<400>  38

Met Glu Ser Gly Gln Pro Ala Arg Arg Ile Ala Met Ala Pro Leu Leu 
1               5                   10                  15      


Glu Tyr Glu Arg Gln Leu Val Leu Glu Leu Leu Asp Thr Asp Gly Leu 
            20                  25                  30          


Val Val Cys Ala Arg Gly Leu Gly Ala Asp Arg Leu Leu Tyr His Phe 
        35                  40                  45              


Leu Gln Leu His Cys His Pro Ala Cys Leu Val Leu Val Leu Asn Thr 
    50                  55                  60                  


Gln Pro Ala Glu Glu Glu Tyr Phe Ile Asn Gln Leu Lys Ile Glu Gly 
65                  70                  75                  80  


Val Glu His Leu Pro Arg Arg Val Thr Asn Glu Ile Thr Ser Asn Ser 
                85                  90                  95      


Arg Tyr Glu Val Tyr Thr Gln Gly Gly Val Ile Phe Ala Thr Ser Arg 
            100                 105                 110         


Ile Leu Val Val Asp Phe Leu Thr Asp Arg Ile Pro Ser Asp Leu Ile 
        115                 120                 125             


Thr Gly Ile Leu Val Tyr Arg Ala His Arg Ile Ile Glu Ser Cys Gln 
    130                 135                 140                 


Glu Ala Phe Ile Leu Arg Leu Phe Arg Gln Lys Asn Lys Arg Gly Phe 
145                 150                 155                 160 


Ile Lys Ala Phe Thr Asp Asn Ala Val Ala Phe Asp Thr Gly Phe Cys 
                165                 170                 175     


His Val Glu Arg Val Met Arg Asn Leu Phe Val Arg Lys Leu Tyr Leu 
            180                 185                 190         


Trp Pro Arg Phe His Val Ala Val Asn Ser Phe Leu Glu Gln His Lys 
        195                 200                 205             


Pro Glu Val Val Glu Ile His Val Ser Met Thr Pro Thr Met Leu Ala 
    210                 215                 220                 


Ile Gln Thr Ala Ile Leu Asp Ile Leu Asn Ala Cys Leu Lys Glu Leu 
225                 230                 235                 240 


Lys Cys His Asn Pro Ser Leu Glu Val Glu Asp Leu Ser Leu Glu Asn 
                245                 250                 255     


Ala Ile Gly Lys Pro Phe Asp Lys Thr Ile Arg His Tyr Leu Asp Pro 
            260                 265                 270         


Leu Trp His Gln Leu Gly Ala Lys Thr Lys Ser Leu Val Gln Asp Leu 
        275                 280                 285             


Lys Ile Leu Arg Thr Leu Leu Gln Tyr Leu Ser Gln Tyr Asp Cys Val 
    290                 295                 300                 


Thr Phe Leu Asn Leu Leu Glu Ser Leu Arg Ala Thr Glu Lys Ala Phe 
305                 310                 315                 320 


Gly Gln Asn Ser Gly Trp Leu Phe Leu Asp Ser Ser Thr Ser Met Phe 
                325                 330                 335     


Ile Asn Ala Arg Ala Arg Val Tyr His Leu Pro Asp Ala Lys Met Ser 
            340                 345                 350         


Lys Lys Glu Lys Ile Ser Glu Lys Met Glu Ile Lys Glu Gly Glu Glu 
        355                 360                 365             


Thr Lys Lys Glu Leu Val Leu Glu Ser Asn Pro Lys Trp Glu Ala Leu 
    370                 375                 380                 


Thr Glu Val Leu Lys Glu Ile Glu Ala Glu Asn Lys Glu Ser Glu Ala 
385                 390                 395                 400 


Leu Gly Gly Pro Gly Gln Val Leu Ile Cys Ala Ser Asp Asp Arg Thr 
                405                 410                 415     


Cys Ser Gln Leu Arg Asp Tyr Ile Thr Leu Gly Ala Glu Ala Phe Leu 
            420                 425                 430         


Leu Arg Leu Tyr Arg Lys Thr Phe Glu Lys Asp Ser Lys Ala Glu Glu 
        435                 440                 445             


Val Trp Met Lys Phe Arg Lys Glu Asp Ser Ser Lys Arg Ile Arg Lys 
    450                 455                 460                 


Ser His Lys Arg Pro Lys Asp Pro Gln Asn Lys Glu Arg Ala Ser Thr 
465                 470                 475                 480 


Lys Glu Arg Thr Leu Lys Lys Lys Lys Arg Lys Leu Thr Leu Thr Gln 
                485                 490                 495     


Met Val Gly Lys Pro Glu Glu Leu Glu Glu Glu Gly Asp Val Glu Glu 
            500                 505                 510         


Gly Tyr Arg Arg Glu Ile Ser Ser Ser Pro Glu Ser Cys Pro Glu Glu 
        515                 520                 525             


Ile Lys His Glu Glu Phe Asp Val Asn Leu Ser Ser Asp Ala Ala Phe 
    530                 535                 540                 


Gly Ile Leu Lys Glu Pro Leu Thr Ile Ile His Pro Leu Leu Gly Cys 
545                 550                 555                 560 


Ser Asp Pro Tyr Ala Leu Thr Arg Val Leu His Glu Val Glu Pro Arg 
                565                 570                 575     


Tyr Val Val Leu Tyr Asp Ala Glu Leu Thr Phe Val Arg Gln Leu Glu 
            580                 585                 590         


Ile Tyr Arg Ala Ser Arg Pro Gly Lys Pro Leu Arg Val Tyr Phe Leu 
        595                 600                 605             


Ile Tyr Gly Gly Ser Thr Glu Glu Gln Arg Tyr Leu Thr Ala Leu Arg 
    610                 615                 620                 


Lys Glu Lys Glu Ala Phe Glu Lys Leu Ile Arg Glu Lys Ala Ser Met 
625                 630                 635                 640 


Val Val Pro Glu Glu Arg Glu Gly Arg Asp Glu Thr Asn Leu Asp Leu 
                645                 650                 655     


Val Arg Gly Thr Ala Ser Ala Asp Val Ser Thr Asp Thr Arg Lys Ala 
            660                 665                 670         


Gly Gly Gln Glu Gln Asn Gly Thr Gln Gln Ser Ile Val Val Asp Met 
        675                 680                 685             


Arg Glu Phe Arg Ser Glu Leu Pro Ser Leu Ile His Arg Arg Gly Ile 
    690                 695                 700                 


Asp Ile Glu Pro Val Thr Leu Glu Val Gly Asp Tyr Ile Leu Thr Pro 
705                 710                 715                 720 


Glu Met Cys Val Glu Arg Lys Ser Ile Ser Asp Leu Ile Gly Ser Leu 
                725                 730                 735     


Asn Asn Gly Arg Leu Tyr Ser Gln Cys Ile Ser Met Ser Arg Tyr Tyr 
            740                 745                 750         


Lys Arg Pro Val Leu Leu Ile Glu Phe Asp Pro Ser Lys Pro Phe Ser 
        755                 760                 765             


Leu Thr Ser Arg Gly Ala Leu Phe Gln Glu Ile Ser Ser Asn Asp Ile 
    770                 775                 780                 


Ser Ser Lys Leu Thr Leu Leu Thr Leu His Phe Pro Arg Leu Arg Ile 
785                 790                 795                 800 


Leu Trp Cys Pro Ser Pro His Ala Thr Ala Glu Leu Phe Glu Glu Leu 
                805                 810                 815     


Lys Gln Ser Lys Pro Gln Pro Asp Ala Ala Thr Ala Leu Ala Ile Thr 
            820                 825                 830         


Ala Asp Ser Glu Thr Leu Pro Glu Ser Glu Lys Tyr Asn Pro Gly Pro 
        835                 840                 845             


Gln Asp Phe Leu Leu Lys Met Pro Gly Val Asn Ala Lys Asn Cys Arg 
    850                 855                 860                 


Ser Leu Met His His Val Lys Asn Ile Ala Glu Leu Ala Ala Leu Ser 
865                 870                 875                 880 


Gln Asp Glu Leu Thr Ser Ile Leu Gly Asn Ala Ala Asn Ala Lys Gln 
                885                 890                 895     


Leu Tyr Asp Phe Ile His Thr Ser Phe Ala Glu Val Val Ser Lys Gly 
            900                 905                 910         


Lys Gly Lys Lys 
        915     


<210>  39
<211>  962
<212>  PRT
<213>  homo sapiens

<400>  39

Met Glu Ser Gly Gln Pro Ala Arg Arg Ile Ala Met Ala Pro Leu Leu 
1               5                   10                  15      


Glu Tyr Glu Arg Gln Leu Val Leu Glu Leu Leu Asp Thr Asp Gly Leu 
            20                  25                  30          


Val Val Cys Ala Arg Gly Leu Gly Ala Asp Arg Leu Leu Tyr His Phe 
        35                  40                  45              


Leu Gln Leu His Cys His Pro Ala Cys Leu Val Leu Val Leu Asn Thr 
    50                  55                  60                  


Gln Pro Ala Glu Glu Glu Tyr Phe Ile Asn Gln Leu Lys Ile Glu Gly 
65                  70                  75                  80  


Val Glu His Leu Pro Arg Arg Val Thr Asn Glu Ile Thr Ser Asn Ser 
                85                  90                  95      


Arg Tyr Glu Val Tyr Thr Gln Gly Gly Val Ile Phe Ala Thr Ser Arg 
            100                 105                 110         


Ile Leu Val Val Asp Phe Leu Thr Asp Arg Ile Pro Ser Asp Leu Ile 
        115                 120                 125             


Thr Glu Ile Leu Pro Leu Thr Cys Gln Lys His Pro Thr Pro Gly Pro 
    130                 135                 140                 


Val Pro Ser Leu Ser Pro Gln Pro Gly Ser Leu Glu Leu Ser Trp Pro 
145                 150                 155                 160 


Arg Trp Ser Gln Gly Ser Ile Gln Pro Leu Phe Arg Tyr His Leu Gly 
                165                 170                 175     


Ile Leu Val Tyr Arg Ala His Arg Ile Ile Glu Ser Cys Gln Glu Ala 
            180                 185                 190         


Phe Ile Leu Arg Leu Phe Arg Gln Lys Asn Lys Arg Gly Phe Ile Lys 
        195                 200                 205             


Ala Phe Thr Asp Asn Ala Val Ala Phe Asp Thr Gly Phe Cys His Val 
    210                 215                 220                 


Glu Arg Val Met Arg Asn Leu Phe Val Arg Lys Leu Tyr Leu Trp Pro 
225                 230                 235                 240 


Arg Phe His Val Ala Val Asn Ser Phe Leu Glu Gln His Lys Pro Glu 
                245                 250                 255     


Val Val Glu Ile His Val Ser Met Thr Pro Thr Met Leu Ala Ile Gln 
            260                 265                 270         


Thr Ala Ile Leu Asp Ile Leu Asn Ala Cys Leu Lys Glu Leu Lys Cys 
        275                 280                 285             


His Asn Pro Ser Leu Glu Val Glu Asp Leu Ser Leu Glu Asn Ala Ile 
    290                 295                 300                 


Gly Lys Pro Phe Asp Lys Thr Ile Arg His Tyr Leu Asp Pro Leu Trp 
305                 310                 315                 320 


His Gln Leu Gly Ala Lys Thr Lys Ser Leu Val Gln Asp Leu Lys Ile 
                325                 330                 335     


Leu Arg Thr Leu Leu Gln Tyr Leu Ser Gln Tyr Asp Cys Val Thr Phe 
            340                 345                 350         


Leu Asn Leu Leu Glu Ser Leu Arg Ala Thr Glu Lys Ala Phe Gly Gln 
        355                 360                 365             


Asn Ser Gly Trp Leu Phe Leu Asp Ser Ser Thr Ser Met Phe Ile Asn 
    370                 375                 380                 


Ala Arg Ala Arg Val Tyr His Leu Pro Asp Ala Lys Met Ser Lys Lys 
385                 390                 395                 400 


Glu Lys Ile Ser Glu Lys Met Glu Ile Lys Glu Gly Glu Glu Thr Lys 
                405                 410                 415     


Lys Glu Leu Val Leu Glu Ser Asn Pro Lys Trp Glu Ala Leu Thr Glu 
            420                 425                 430         


Val Leu Lys Glu Ile Glu Ala Glu Asn Lys Glu Ser Glu Ala Leu Gly 
        435                 440                 445             


Gly Pro Gly Gln Val Leu Ile Cys Ala Ser Asp Asp Arg Thr Cys Ser 
    450                 455                 460                 


Gln Leu Arg Asp Tyr Ile Thr Leu Gly Ala Glu Ala Phe Leu Leu Arg 
465                 470                 475                 480 


Leu Tyr Arg Lys Thr Phe Glu Lys Asp Ser Lys Ala Glu Glu Val Trp 
                485                 490                 495     


Met Lys Phe Arg Lys Glu Asp Ser Ser Lys Arg Ile Arg Lys Ser His 
            500                 505                 510         


Lys Arg Pro Lys Asp Pro Gln Asn Lys Glu Arg Ala Ser Thr Lys Glu 
        515                 520                 525             


Arg Thr Leu Lys Lys Lys Lys Arg Lys Leu Thr Leu Thr Gln Met Val 
    530                 535                 540                 


Gly Lys Pro Glu Glu Leu Glu Glu Glu Gly Asp Val Glu Glu Gly Tyr 
545                 550                 555                 560 


Arg Arg Glu Ile Ser Ser Ser Pro Glu Ser Cys Pro Glu Glu Ile Lys 
                565                 570                 575     


His Glu Glu Phe Asp Val Asn Leu Ser Ser Asp Ala Ala Phe Gly Ile 
            580                 585                 590         


Leu Lys Glu Pro Leu Thr Ile Ile His Pro Leu Leu Gly Cys Ser Asp 
        595                 600                 605             


Pro Tyr Ala Leu Thr Arg Val Leu His Glu Val Glu Pro Arg Tyr Val 
    610                 615                 620                 


Val Leu Tyr Asp Ala Glu Leu Thr Phe Val Arg Gln Leu Glu Ile Tyr 
625                 630                 635                 640 


Arg Ala Ser Arg Pro Gly Lys Pro Leu Arg Val Tyr Phe Leu Ile Tyr 
                645                 650                 655     


Gly Gly Ser Thr Glu Glu Gln Arg Tyr Leu Thr Ala Leu Arg Lys Glu 
            660                 665                 670         


Lys Glu Ala Phe Glu Lys Leu Ile Arg Glu Lys Ala Ser Met Val Val 
        675                 680                 685             


Pro Glu Glu Arg Glu Gly Arg Asp Glu Thr Asn Leu Asp Leu Val Arg 
    690                 695                 700                 


Gly Thr Ala Ser Ala Asp Val Ser Thr Asp Thr Arg Lys Ala Gly Gly 
705                 710                 715                 720 


Gln Glu Gln Asn Gly Thr Gln Gln Ser Ile Val Val Asp Met Arg Glu 
                725                 730                 735     


Phe Arg Ser Glu Leu Pro Ser Leu Ile His Arg Arg Gly Ile Asp Ile 
            740                 745                 750         


Glu Pro Val Thr Leu Glu Val Gly Asp Tyr Ile Leu Thr Pro Glu Met 
        755                 760                 765             


Cys Val Glu Arg Lys Ser Ile Ser Asp Leu Ile Gly Ser Leu Asn Asn 
    770                 775                 780                 


Gly Arg Leu Tyr Ser Gln Cys Ile Ser Met Ser Arg Tyr Tyr Lys Arg 
785                 790                 795                 800 


Pro Val Leu Leu Ile Glu Phe Asp Pro Ser Lys Pro Phe Ser Leu Thr 
                805                 810                 815     


Ser Arg Gly Ala Leu Phe Gln Glu Ile Ser Ser Asn Asp Ile Ser Ser 
            820                 825                 830         


Lys Leu Thr Leu Leu Thr Leu His Phe Pro Arg Leu Arg Ile Leu Trp 
        835                 840                 845             


Cys Pro Ser Pro His Ala Thr Ala Glu Leu Phe Glu Glu Leu Lys Gln 
    850                 855                 860                 


Ser Lys Pro Gln Pro Asp Ala Ala Thr Ala Leu Ala Ile Thr Ala Asp 
865                 870                 875                 880 


Ser Glu Thr Leu Pro Glu Ser Glu Lys Tyr Asn Pro Gly Pro Gln Asp 
                885                 890                 895     


Phe Leu Leu Lys Met Pro Gly Val Asn Ala Lys Asn Cys Arg Ser Leu 
            900                 905                 910         


Met His His Val Lys Asn Ile Ala Glu Leu Ala Ala Leu Ser Gln Asp 
        915                 920                 925             


Glu Leu Thr Ser Ile Leu Gly Asn Ala Ala Asn Ala Lys Gln Leu Tyr 
    930                 935                 940                 


Asp Phe Ile His Thr Ser Phe Ala Glu Val Val Ser Lys Gly Lys Gly 
945                 950                 955                 960 


Lys Lys 
        


<210>  40
<211>  466
<212>  PRT
<213>  homo sapiens

<400>  40

Met Lys Phe Arg Lys Glu Asp Ser Ser Lys Arg Ile Arg Lys Ser His 
1               5                   10                  15      


Lys Arg Pro Lys Asp Pro Gln Asn Lys Glu Arg Ala Ser Thr Lys Glu 
            20                  25                  30          


Arg Thr Leu Lys Lys Lys Lys Arg Lys Leu Thr Leu Thr Gln Met Val 
        35                  40                  45              


Gly Lys Pro Glu Glu Leu Glu Glu Glu Gly Asp Val Glu Glu Gly Tyr 
    50                  55                  60                  


Arg Arg Glu Ile Ser Ser Ser Pro Glu Ser Cys Pro Glu Glu Ile Lys 
65                  70                  75                  80  


His Glu Glu Phe Asp Val Asn Leu Ser Ser Asp Ala Ala Phe Gly Ile 
                85                  90                  95      


Leu Lys Glu Pro Leu Thr Ile Ile His Pro Leu Leu Gly Cys Ser Asp 
            100                 105                 110         


Pro Tyr Ala Leu Thr Arg Val Leu His Glu Val Glu Pro Arg Tyr Val 
        115                 120                 125             


Val Leu Tyr Asp Ala Glu Leu Thr Phe Val Arg Gln Leu Glu Ile Tyr 
    130                 135                 140                 


Arg Ala Ser Arg Pro Gly Lys Pro Leu Arg Val Tyr Phe Leu Ile Tyr 
145                 150                 155                 160 


Gly Gly Ser Thr Glu Glu Gln Arg Tyr Leu Thr Ala Leu Arg Lys Glu 
                165                 170                 175     


Lys Glu Ala Phe Glu Lys Leu Ile Arg Glu Lys Ala Ser Met Val Val 
            180                 185                 190         


Pro Glu Glu Arg Glu Gly Arg Asp Glu Thr Asn Leu Asp Leu Val Arg 
        195                 200                 205             


Gly Thr Ala Ser Ala Asp Val Ser Thr Asp Thr Arg Lys Ala Gly Gly 
    210                 215                 220                 


Gln Glu Gln Asn Gly Thr Gln Gln Ser Ile Val Val Asp Met Arg Glu 
225                 230                 235                 240 


Phe Arg Ser Glu Leu Pro Ser Leu Ile His Arg Arg Gly Ile Asp Ile 
                245                 250                 255     


Glu Pro Val Thr Leu Glu Val Gly Asp Tyr Ile Leu Thr Pro Glu Met 
            260                 265                 270         


Cys Val Glu Arg Lys Ser Ile Ser Asp Leu Ile Gly Ser Leu Asn Asn 
        275                 280                 285             


Gly Arg Leu Tyr Ser Gln Cys Ile Ser Met Ser Arg Tyr Tyr Lys Arg 
    290                 295                 300                 


Pro Val Leu Leu Ile Glu Phe Asp Pro Ser Lys Pro Phe Ser Leu Thr 
305                 310                 315                 320 


Ser Arg Gly Ala Leu Phe Gln Glu Ile Ser Ser Asn Asp Ile Ser Ser 
                325                 330                 335     


Lys Leu Thr Leu Leu Thr Leu His Phe Pro Arg Leu Arg Ile Leu Trp 
            340                 345                 350         


Cys Pro Ser Pro His Ala Thr Ala Glu Leu Phe Glu Glu Leu Lys Gln 
        355                 360                 365             


Ser Lys Pro Gln Pro Asp Ala Ala Thr Ala Leu Ala Ile Thr Ala Asp 
    370                 375                 380                 


Ser Glu Thr Leu Pro Glu Ser Glu Lys Tyr Asn Pro Gly Pro Gln Asp 
385                 390                 395                 400 


Phe Leu Leu Lys Met Pro Gly Val Asn Ala Lys Asn Cys Arg Ser Leu 
                405                 410                 415     


Met His His Val Lys Asn Ile Ala Glu Leu Ala Ala Leu Ser Gln Asp 
            420                 425                 430         


Glu Leu Thr Ser Ile Leu Gly Asn Ala Ala Asn Ala Lys Gln Leu Tyr 
        435                 440                 445             


Asp Phe Ile His Thr Ser Phe Ala Glu Val Val Ser Lys Gly Lys Gly 
    450                 455                 460                 


Lys Lys 
465     


<210>  41
<211>  653
<212>  PRT
<213>  homo sapiens

<400>  41

Met Thr Ile Arg His Tyr Leu Asp Pro Leu Trp His Gln Leu Gly Ala 
1               5                   10                  15      


Lys Thr Lys Ser Leu Val Gln Asp Leu Lys Ile Leu Arg Thr Leu Leu 
            20                  25                  30          


Gln Tyr Leu Ser Gln Tyr Asp Cys Val Thr Phe Leu Asn Leu Leu Glu 
        35                  40                  45              


Ser Leu Arg Ala Thr Glu Lys Ala Phe Gly Gln Asn Ser Gly Trp Leu 
    50                  55                  60                  


Phe Leu Asp Ser Ser Thr Ser Met Phe Ile Asn Ala Arg Ala Arg Val 
65                  70                  75                  80  


Tyr His Leu Pro Asp Ala Lys Met Ser Lys Lys Glu Lys Ile Ser Glu 
                85                  90                  95      


Lys Met Glu Ile Lys Glu Gly Glu Glu Thr Lys Lys Glu Leu Val Leu 
            100                 105                 110         


Glu Ser Asn Pro Lys Trp Glu Ala Leu Thr Glu Val Leu Lys Glu Ile 
        115                 120                 125             


Glu Ala Glu Asn Lys Glu Ser Glu Ala Leu Gly Gly Pro Gly Gln Val 
    130                 135                 140                 


Leu Ile Cys Ala Ser Asp Asp Arg Thr Cys Ser Gln Leu Arg Asp Tyr 
145                 150                 155                 160 


Ile Thr Leu Gly Ala Glu Ala Phe Leu Leu Arg Leu Tyr Arg Lys Thr 
                165                 170                 175     


Phe Glu Lys Asp Ser Lys Ala Glu Glu Val Trp Met Lys Phe Arg Lys 
            180                 185                 190         


Glu Asp Ser Ser Lys Arg Ile Arg Lys Ser His Lys Arg Pro Lys Asp 
        195                 200                 205             


Pro Gln Asn Lys Glu Arg Ala Ser Thr Lys Glu Arg Thr Leu Lys Lys 
    210                 215                 220                 


Lys Lys Arg Lys Leu Thr Leu Thr Gln Met Val Gly Lys Pro Glu Glu 
225                 230                 235                 240 


Leu Glu Glu Glu Gly Asp Val Glu Glu Gly Tyr Arg Arg Glu Ile Ser 
                245                 250                 255     


Ser Ser Pro Glu Ser Cys Pro Glu Glu Ile Lys His Glu Glu Phe Asp 
            260                 265                 270         


Val Asn Leu Ser Ser Asp Ala Ala Phe Gly Ile Leu Lys Glu Pro Leu 
        275                 280                 285             


Thr Ile Ile His Pro Leu Leu Gly Cys Ser Asp Pro Tyr Ala Leu Thr 
    290                 295                 300                 


Arg Val Leu His Glu Val Glu Pro Arg Tyr Val Val Leu Tyr Asp Ala 
305                 310                 315                 320 


Glu Leu Thr Phe Val Arg Gln Leu Glu Ile Tyr Arg Ala Ser Arg Pro 
                325                 330                 335     


Gly Lys Pro Leu Arg Val Tyr Phe Leu Ile Tyr Gly Gly Ser Thr Glu 
            340                 345                 350         


Glu Gln Arg Tyr Leu Thr Ala Leu Arg Lys Glu Lys Glu Ala Phe Glu 
        355                 360                 365             


Lys Leu Ile Arg Glu Lys Ala Ser Met Val Val Pro Glu Glu Arg Glu 
    370                 375                 380                 


Gly Arg Asp Glu Thr Asn Leu Asp Leu Val Arg Gly Thr Ala Ser Ala 
385                 390                 395                 400 


Asp Val Ser Thr Asp Thr Arg Lys Ala Gly Gly Gln Glu Gln Asn Gly 
                405                 410                 415     


Thr Gln Gln Ser Ile Val Val Asp Met Arg Glu Phe Arg Ser Glu Leu 
            420                 425                 430         


Pro Ser Leu Ile His Arg Arg Gly Ile Asp Ile Glu Pro Val Thr Leu 
        435                 440                 445             


Glu Val Gly Asp Tyr Ile Leu Thr Pro Glu Met Cys Val Glu Arg Lys 
    450                 455                 460                 


Ser Ile Ser Asp Leu Ile Gly Ser Leu Asn Asn Gly Arg Leu Tyr Ser 
465                 470                 475                 480 


Gln Cys Ile Ser Met Ser Arg Tyr Tyr Lys Arg Pro Val Leu Leu Ile 
                485                 490                 495     


Glu Phe Asp Pro Ser Lys Pro Phe Ser Leu Thr Ser Arg Gly Ala Leu 
            500                 505                 510         


Phe Gln Glu Ile Ser Ser Asn Asp Ile Ser Ser Lys Leu Thr Leu Leu 
        515                 520                 525             


Thr Leu His Phe Pro Arg Leu Arg Ile Leu Trp Cys Pro Ser Pro His 
    530                 535                 540                 


Ala Thr Ala Glu Leu Phe Glu Glu Leu Lys Gln Ser Lys Pro Gln Pro 
545                 550                 555                 560 


Asp Ala Ala Thr Ala Leu Ala Ile Thr Ala Asp Ser Glu Thr Leu Pro 
                565                 570                 575     


Glu Ser Glu Lys Tyr Asn Pro Gly Pro Gln Asp Phe Leu Leu Lys Met 
            580                 585                 590         


Pro Gly Val Asn Ala Lys Asn Cys Arg Ser Leu Met His His Val Lys 
        595                 600                 605             


Asn Ile Ala Glu Leu Ala Ala Leu Ser Gln Asp Glu Leu Thr Ser Ile 
    610                 615                 620                 


Leu Gly Asn Ala Ala Asn Ala Lys Gln Leu Tyr Asp Phe Ile His Thr 
625                 630                 635                 640 


Ser Phe Ala Glu Val Val Ser Lys Gly Lys Gly Lys Lys 
                645                 650             


<210>  42
<211>  323
<212>  PRT
<213>  homo sapiens

<400>  42

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              


Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  


Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  


Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      


Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         


Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             


Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 


Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 


Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     


Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         


Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             


Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 


Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Val Thr Glu Cys Leu Thr 
225                 230                 235                 240 


Thr Val Lys Ser Val Asn Lys Thr Asp Ser Gln Thr Leu Leu Thr Thr 
                245                 250                 255     


Phe Gly Ser Leu Glu Gln Leu Ile Ala Ala Ser Arg Glu Asp Leu Ala 
            260                 265                 270         


Leu Cys Pro Gly Leu Gly Pro Gln Lys Val Arg Ala Leu Gly Lys Asn 
        275                 280                 285             


Pro Arg Ser Trp Gly Lys Glu Arg Ala Pro Asn Lys His Asn Leu Arg 
    290                 295                 300                 


Pro Gln Ser Phe Lys Val Lys Lys Glu Pro Lys Thr Arg His Ser Gly 
305                 310                 315                 320 


Phe Arg Leu 
            


<210>  43
<211>  297
<212>  PRT
<213>  homo sapiens

<400>  43

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              


Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  


Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  


Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      


Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         


Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             


Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 


Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 


Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     


Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         


Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             


Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 


Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Val Thr Glu Cys Leu Thr 
225                 230                 235                 240 


Thr Val Lys Ser Val Asn Lys Thr Asp Ser Gln Thr Leu Leu Thr Thr 
                245                 250                 255     


Phe Gly Ser Leu Glu Gln Leu Ile Ala Ala Ser Arg Glu Asp Leu Ala 
            260                 265                 270         


Leu Cys Pro Gly Leu Gly Pro Gln Lys Ala Arg Arg Leu Phe Asp Val 
        275                 280                 285             


Leu His Glu Pro Phe Leu Lys Val Pro 
    290                 295         


<210>  44
<211>  273
<212>  PRT
<213>  homo sapiens

<400>  44

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              


Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  


Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  


Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      


Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         


Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             


Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 


Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 


Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     


Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         


Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             


Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 


Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Ser Leu Glu Gln Leu Ile 
225                 230                 235                 240 


Ala Ala Ser Arg Glu Asp Leu Ala Leu Cys Pro Gly Leu Gly Pro Gln 
                245                 250                 255     


Lys Ala Arg Arg Leu Phe Asp Val Leu His Glu Pro Phe Leu Lys Val 
            260                 265                 270         


Pro 
    


<210>  45
<211>  299
<212>  PRT
<213>  homo sapiens

<400>  45

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              


Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  


Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  


Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      


Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         


Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             


Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 


Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 


Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     


Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         


Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             


Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 


Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Ser Leu Glu Gln Leu Ile 
225                 230                 235                 240 


Ala Ala Ser Arg Glu Asp Leu Ala Leu Cys Pro Gly Leu Gly Pro Gln 
                245                 250                 255     


Lys Val Arg Ala Leu Gly Lys Asn Pro Arg Ser Trp Gly Lys Glu Arg 
            260                 265                 270         


Ala Pro Asn Lys His Asn Leu Arg Pro Gln Ser Phe Lys Val Lys Lys 
        275                 280                 285             


Glu Pro Lys Thr Arg His Ser Gly Phe Arg Leu 
    290                 295                 


<210>  46
<211>  2590
<212>  PRT
<213>  homo sapiens

<400>  46

Met Asn Leu Leu Arg Arg Ser Gly Lys Arg Arg Arg Ser Glu Ser Gly 
1               5                   10                  15      


Ser Asp Ser Phe Ser Gly Ser Gly Gly Asp Ser Ser Ala Ser Pro Gln 
            20                  25                  30          


Phe Leu Ser Gly Ser Val Leu Ser Pro Pro Pro Gly Leu Gly Arg Cys 
        35                  40                  45              


Leu Lys Ala Ala Ala Ala Gly Glu Cys Lys Pro Thr Val Pro Asp Tyr 
    50                  55                  60                  


Glu Arg Asp Lys Leu Leu Leu Ala Asn Trp Gly Leu Pro Lys Ala Val 
65                  70                  75                  80  


Leu Glu Lys Tyr His Ser Phe Gly Val Lys Lys Met Phe Glu Trp Gln 
                85                  90                  95      


Ala Glu Cys Leu Leu Leu Gly Gln Val Leu Glu Gly Lys Asn Leu Val 
            100                 105                 110         


Tyr Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ala Glu Leu Leu 
        115                 120                 125             


Ile Leu Lys Arg Val Leu Glu Met Arg Lys Lys Ala Leu Phe Ile Leu 
    130                 135                 140                 


Pro Phe Val Ser Val Ala Lys Glu Lys Lys Tyr Tyr Leu Gln Ser Leu 
145                 150                 155                 160 


Phe Gln Glu Val Gly Ile Lys Val Asp Gly Tyr Met Gly Ser Thr Ser 
                165                 170                 175     


Pro Ser Arg His Phe Ser Ser Leu Asp Ile Ala Val Cys Thr Ile Glu 
            180                 185                 190         


Arg Ala Asn Gly Leu Ile Asn Arg Leu Ile Glu Glu Asn Lys Met Asp 
        195                 200                 205             


Leu Leu Gly Met Val Val Val Asp Glu Leu His Met Leu Gly Asp Ser 
    210                 215                 220                 


His Arg Gly Tyr Leu Leu Glu Leu Leu Leu Thr Lys Ile Cys Tyr Ile 
225                 230                 235                 240 


Thr Arg Lys Ser Ala Ser Cys Gln Ala Asp Leu Ala Ser Ser Leu Ser 
                245                 250                 255     


Asn Ala Val Gln Ile Val Gly Met Ser Ala Thr Leu Pro Asn Leu Glu 
            260                 265                 270         


Leu Val Ala Ser Trp Leu Asn Ala Glu Leu Tyr His Thr Asp Phe Arg 
        275                 280                 285             


Pro Val Pro Leu Leu Glu Ser Val Lys Val Gly Asn Ser Ile Tyr Asp 
    290                 295                 300                 


Ser Ser Met Lys Leu Val Arg Glu Phe Glu Pro Met Leu Gln Val Lys 
305                 310                 315                 320 


Gly Asp Glu Asp His Val Val Ser Leu Cys Tyr Glu Thr Ile Cys Asp 
                325                 330                 335     


Asn His Ser Val Leu Leu Phe Cys Pro Ser Lys Lys Trp Cys Glu Lys 
            340                 345                 350         


Leu Ala Asp Ile Ile Ala Arg Glu Phe Tyr Asn Leu His His Gln Ala 
        355                 360                 365             


Glu Gly Leu Val Lys Pro Ser Glu Cys Pro Pro Val Ile Leu Glu Gln 
    370                 375                 380                 


Lys Glu Leu Leu Glu Val Met Asp Gln Leu Arg Arg Leu Pro Ser Gly 
385                 390                 395                 400 


Leu Asp Ser Val Leu Gln Lys Thr Val Pro Trp Gly Val Ala Phe His 
                405                 410                 415     


His Ala Gly Leu Thr Phe Glu Glu Arg Asp Ile Ile Glu Gly Ala Phe 
            420                 425                 430         


Arg Gln Gly Leu Ile Arg Val Leu Ala Ala Thr Ser Thr Leu Ser Ser 
        435                 440                 445             


Gly Val Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Thr Pro Ile Phe 
    450                 455                 460                 


Gly Gly Arg Pro Leu Asp Ile Leu Thr Tyr Lys Gln Met Val Gly Arg 
465                 470                 475                 480 


Ala Gly Arg Lys Gly Val Asp Thr Val Gly Glu Ser Ile Leu Ile Cys 
                485                 490                 495     


Lys Asn Ser Glu Lys Ser Lys Gly Ile Ala Leu Leu Gln Gly Ser Leu 
            500                 505                 510         


Lys Pro Val Arg Ser Cys Leu Gln Arg Arg Glu Gly Glu Glu Val Thr 
        515                 520                 525             


Gly Ser Met Ile Arg Ala Ile Leu Glu Ile Ile Val Gly Gly Val Ala 
    530                 535                 540                 


Ser Thr Ser Gln Asp Met His Thr Tyr Ala Ala Cys Thr Phe Leu Ala 
545                 550                 555                 560 


Ala Ser Met Lys Glu Gly Lys Gln Gly Ile Gln Arg Asn Gln Glu Ser 
                565                 570                 575     


Val Gln Leu Gly Ala Ile Glu Ala Cys Val Met Trp Leu Leu Glu Asn 
            580                 585                 590         


Glu Phe Ile Gln Ser Thr Glu Ala Ser Asp Gly Thr Glu Gly Lys Val 
        595                 600                 605             


Tyr His Pro Thr His Leu Gly Ser Ala Thr Leu Ser Ser Ser Leu Ser 
    610                 615                 620                 


Pro Ala Asp Thr Leu Asp Ile Phe Ala Asp Leu Gln Arg Ala Met Lys 
625                 630                 635                 640 


Gly Phe Val Leu Glu Asn Asp Leu His Ile Leu Tyr Leu Val Thr Pro 
                645                 650                 655     


Met Phe Glu Asp Trp Thr Thr Ile Asp Trp Tyr Arg Phe Phe Cys Leu 
            660                 665                 670         


Trp Glu Lys Leu Pro Thr Ser Met Lys Arg Val Ala Glu Leu Val Gly 
        675                 680                 685             


Val Glu Glu Gly Phe Leu Ala Arg Cys Val Lys Gly Lys Val Val Ala 
    690                 695                 700                 


Arg Thr Glu Arg Gln His Arg Gln Met Ala Ile His Lys Arg Phe Phe 
705                 710                 715                 720 


Thr Ser Leu Val Leu Leu Asp Leu Ile Ser Glu Val Pro Leu Arg Glu 
                725                 730                 735     


Ile Asn Gln Lys Tyr Gly Cys Asn Arg Gly Gln Ile Gln Ser Leu Gln 
            740                 745                 750         


Gln Ser Ala Ala Val Tyr Ala Gly Met Ile Thr Val Phe Ser Asn Arg 
        755                 760                 765             


Leu Gly Trp His Asn Met Glu Leu Leu Leu Ser Gln Phe Gln Lys Arg 
    770                 775                 780                 


Leu Thr Phe Gly Ile Gln Arg Glu Leu Cys Asp Leu Val Arg Val Ser 
785                 790                 795                 800 


Leu Leu Asn Ala Gln Arg Ala Arg Val Leu Tyr Ala Ser Gly Phe His 
                805                 810                 815     


Thr Val Ala Asp Leu Ala Arg Ala Asn Ile Val Glu Val Glu Val Ile 
            820                 825                 830         


Leu Lys Asn Ala Val Pro Phe Lys Ser Ala Arg Lys Ala Val Asp Glu 
        835                 840                 845             


Glu Glu Glu Ala Val Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val 
    850                 855                 860                 


Thr Gly Arg Lys Gly Leu Thr Glu Arg Glu Ala Ala Ala Leu Ile Val 
865                 870                 875                 880 


Glu Glu Ala Arg Met Ile Leu Gln Gln Asp Leu Val Glu Met Gly Val 
                885                 890                 895     


Gln Trp Asn Pro Cys Ala Leu Leu His Ser Ser Thr Cys Ser Leu Thr 
            900                 905                 910         


His Ser Glu Ser Glu Val Lys Glu His Thr Phe Ile Ser Gln Thr Lys 
        915                 920                 925             


Ser Ser Tyr Lys Lys Leu Thr Ser Lys Asn Lys Ser Asn Thr Ile Phe 
    930                 935                 940                 


Ser Asp Ser Tyr Ile Lys His Ser Pro Asn Ile Val Gln Asp Leu Asn 
945                 950                 955                 960 


Lys Ser Arg Glu His Thr Ser Ser Phe Asn Cys Asn Phe Gln Asn Gly 
                965                 970                 975     


Asn Gln Glu His Gln Thr Cys Ser Ile Phe Arg Ala Arg Lys Arg Ala 
            980                 985                 990         


Ser Leu Asp Ile Asn Lys Glu Lys  Pro Gly Ala Ser Gln  Asn Glu Gly 
        995                 1000                 1005             


Lys Thr  Ser Asp Lys Lys Val  Val Gln Thr Phe Ser  Gln Lys Thr 
    1010                 1015                 1020             


Lys Lys  Ala Pro Leu Asn Phe  Asn Ser Glu Lys Met  Ser Arg Ser 
    1025                 1030                 1035             


Phe Arg  Ser Trp Lys Arg Arg  Lys His Leu Lys Arg  Ser Arg Asp 
    1040                 1045                 1050             


Ser Ser  Pro Leu Lys Asp Ser  Gly Ala Cys Arg Ile  His Leu Gln 
    1055                 1060                 1065             


Gly Gln  Thr Leu Ser Asn Pro  Ser Leu Cys Glu Asp  Pro Phe Thr 
    1070                 1075                 1080             


Leu Asp  Glu Lys Lys Thr Glu  Phe Arg Asn Ser Gly  Pro Phe Ala 
    1085                 1090                 1095             


Lys Asn  Val Ser Leu Ser Gly  Lys Glu Lys Asp Asn  Lys Thr Ser 
    1100                 1105                 1110             


Phe Pro  Leu Gln Ile Lys Gln  Asn Cys Ser Trp Asn  Ile Thr Leu 
    1115                 1120                 1125             


Thr Asn  Asp Asn Phe Val Glu  His Ile Val Thr Gly  Ser Gln Ser 
    1130                 1135                 1140             


Lys Asn  Val Thr Cys Gln Ala  Thr Ser Val Val Ser  Glu Lys Gly 
    1145                 1150                 1155             


Arg Gly  Val Ala Val Glu Ala  Glu Lys Ile Asn Glu  Val Leu Ile 
    1160                 1165                 1170             


Gln Asn  Gly Ser Lys Asn Gln  Asn Val Tyr Met Lys  His His Asp 
    1175                 1180                 1185             


Ile His  Pro Ile Asn Gln Tyr  Leu Arg Lys Gln Ser  His Glu Gln 
    1190                 1195                 1200             


Thr Ser  Thr Ile Thr Lys Gln  Lys Asn Ile Ile Glu  Arg Gln Met 
    1205                 1210                 1215             


Pro Cys  Glu Ala Val Ser Ser  Tyr Ile Asn Arg Asp  Ser Asn Val 
    1220                 1225                 1230             


Thr Ile  Asn Cys Glu Arg Ile  Lys Leu Asn Thr Glu  Glu Asn Lys 
    1235                 1240                 1245             


Pro Ser  His Phe Gln Ala Leu  Gly Asp Asp Ile Ser  Arg Thr Val 
    1250                 1255                 1260             


Ile Pro  Ser Glu Val Leu Pro  Ser Ala Gly Ala Phe  Ser Lys Ser 
    1265                 1270                 1275             


Glu Gly  Gln His Glu Asn Phe  Leu Asn Ile Ser Arg  Leu Gln Glu 
    1280                 1285                 1290             


Lys Thr  Gly Thr Tyr Thr Thr  Asn Lys Thr Lys Asn  Asn His Val 
    1295                 1300                 1305             


Ser Asp  Leu Gly Leu Val Leu  Cys Asp Phe Glu Asp  Ser Phe Tyr 
    1310                 1315                 1320             


Leu Asp  Thr Gln Ser Glu Lys  Ile Ile Gln Gln Met  Ala Thr Glu 
    1325                 1330                 1335             


Asn Ala  Lys Leu Gly Ala Lys  Asp Thr Asn Leu Ala  Ala Gly Ile 
    1340                 1345                 1350             


Met Gln  Lys Ser Leu Val Gln  Gln Asn Ser Met Asn  Ser Phe Gln 
    1355                 1360                 1365             


Lys Glu  Cys His Ile Pro Phe  Pro Ala Glu Gln His  Pro Leu Gly 
    1370                 1375                 1380             


Ala Thr  Lys Ile Asp His Leu  Asp Leu Lys Thr Val  Gly Thr Met 
    1385                 1390                 1395             


Lys Gln  Ser Ser Asp Ser His  Gly Val Asp Ile Leu  Thr Pro Glu 
    1400                 1405                 1410             


Ser Pro  Ile Phe His Ser Pro  Ile Leu Leu Glu Glu  Asn Gly Leu 
    1415                 1420                 1425             


Phe Leu  Lys Lys Asn Glu Val  Ser Val Thr Asp Ser  Gln Leu Asn 
    1430                 1435                 1440             


Ser Phe  Leu Gln Gly Tyr Gln  Thr Gln Glu Thr Val  Lys Pro Val 
    1445                 1450                 1455             


Ile Leu  Leu Ile Pro Gln Lys  Arg Thr Pro Thr Gly  Val Glu Gly 
    1460                 1465                 1470             


Glu Cys  Leu Pro Val Pro Glu  Thr Ser Leu Asn Met  Ser Asp Ser 
    1475                 1480                 1485             


Leu Leu  Phe Asp Ser Phe Ser  Asp Asp Tyr Leu Val  Lys Glu Gln 
    1490                 1495                 1500             


Leu Pro  Asp Met Gln Met Lys  Glu Pro Leu Pro Ser  Glu Val Thr 
    1505                 1510                 1515             


Ser Asn  His Phe Ser Asp Ser  Leu Cys Leu Gln Glu  Asp Leu Ile 
    1520                 1525                 1530             


Lys Lys  Ser Asn Val Asn Glu  Asn Gln Asp Thr His  Gln Gln Leu 
    1535                 1540                 1545             


Thr Cys  Ser Asn Asp Glu Ser  Ile Ile Phe Ser Glu  Met Asp Ser 
    1550                 1555                 1560             


Val Gln  Met Val Glu Ala Leu  Asp Asn Val Asp Ile  Phe Pro Val 
    1565                 1570                 1575             


Gln Glu  Lys Asn His Thr Val  Val Ser Pro Arg Ala  Leu Glu Leu 
    1580                 1585                 1590             


Ser Asp  Pro Val Leu Asp Glu  His His Gln Gly Asp  Gln Asp Gly 
    1595                 1600                 1605             


Gly Asp  Gln Asp Glu Arg Ala  Glu Lys Ser Lys Leu  Thr Gly Thr 
    1610                 1615                 1620             


Arg Gln  Asn His Ser Phe Ile  Trp Ser Gly Ala Ser  Phe Asp Leu 
    1625                 1630                 1635             


Ser Pro  Gly Leu Gln Arg Ile  Leu Asp Lys Val Ser  Ser Pro Leu 
    1640                 1645                 1650             


Glu Asn  Glu Lys Leu Lys Ser  Met Thr Ile Asn Phe  Ser Ser Leu 
    1655                 1660                 1665             


Asn Arg  Lys Asn Thr Glu Leu  Asn Glu Glu Gln Glu  Val Ile Ser 
    1670                 1675                 1680             


Asn Leu  Glu Thr Lys Gln Val  Gln Gly Ile Ser Phe  Ser Ser Asn 
    1685                 1690                 1695             


Asn Glu  Val Lys Ser Lys Ile  Glu Met Leu Glu Asn  Asn Ala Asn 
    1700                 1705                 1710             


His Asp  Glu Thr Ser Ser Leu  Leu Pro Arg Lys Glu  Ser Asn Ile 
    1715                 1720                 1725             


Val Asp  Asp Asn Gly Leu Ile  Pro Pro Thr Pro Ile  Pro Thr Ser 
    1730                 1735                 1740             


Ala Ser  Lys Leu Thr Phe Pro  Gly Ile Leu Glu Thr  Pro Val Asn 
    1745                 1750                 1755             


Pro Trp  Lys Thr Asn Asn Val  Leu Gln Pro Gly Glu  Ser Tyr Leu 
    1760                 1765                 1770             


Phe Gly  Ser Pro Ser Asp Ile  Lys Asn His Asp Leu  Ser Pro Gly 
    1775                 1780                 1785             


Ser Arg  Asn Gly Phe Lys Asp  Asn Ser Pro Ile Ser  Asp Thr Ser 
    1790                 1795                 1800             


Phe Ser  Leu Gln Leu Ser Gln  Asp Gly Leu Gln Leu  Thr Pro Ala 
    1805                 1810                 1815             


Ser Ser  Ser Ser Glu Ser Leu  Ser Ile Ile Asp Val  Ala Ser Asp 
    1820                 1825                 1830             


Gln Asn  Leu Phe Gln Thr Phe  Ile Lys Glu Trp Arg  Cys Lys Lys 
    1835                 1840                 1845             


Arg Phe  Ser Ile Ser Leu Ala  Cys Glu Lys Ile Arg  Ser Leu Thr 
    1850                 1855                 1860             


Ser Ser  Lys Thr Ala Thr Ile  Gly Ser Arg Phe Lys  Gln Ala Ser 
    1865                 1870                 1875             


Ser Pro  Gln Glu Ile Pro Ile  Arg Asp Asp Gly Phe  Pro Ile Lys 
    1880                 1885                 1890             


Gly Cys  Asp Asp Thr Leu Val  Val Gly Leu Ala Val  Cys Trp Gly 
    1895                 1900                 1905             


Gly Arg  Asp Ala Tyr Tyr Phe  Ser Leu Gln Lys Glu  Gln Lys His 
    1910                 1915                 1920             


Ser Glu  Ile Ser Ala Ser Leu  Val Pro Pro Ser Leu  Asp Pro Ser 
    1925                 1930                 1935             


Leu Thr  Leu Lys Asp Arg Met  Trp Tyr Leu Gln Ser  Cys Leu Arg 
    1940                 1945                 1950             


Lys Glu  Ser Asp Lys Glu Cys  Ser Val Val Ile Tyr  Asp Phe Ile 
    1955                 1960                 1965             


Gln Ser  Tyr Lys Ile Leu Leu  Leu Ser Cys Gly Ile  Ser Leu Glu 
    1970                 1975                 1980             


Gln Ser  Tyr Glu Asp Pro Lys  Val Ala Cys Trp Leu  Leu Asp Pro 
    1985                 1990                 1995             


Asp Ser  Gln Glu Pro Thr Leu  His Ser Ile Val Thr  Ser Phe Leu 
    2000                 2005                 2010             


Pro His  Glu Leu Pro Leu Leu  Glu Gly Met Glu Thr  Ser Gln Gly 
    2015                 2020                 2025             


Ile Gln  Ser Leu Gly Leu Asn  Ala Gly Ser Glu His  Ser Gly Arg 
    2030                 2035                 2040             


Tyr Arg  Ala Ser Val Glu Ser  Ile Leu Ile Phe Asn  Ser Met Asn 
    2045                 2050                 2055             


Gln Leu  Asn Ser Leu Leu Gln  Lys Glu Asn Leu Gln  Asp Val Phe 
    2060                 2065                 2070             


Arg Lys  Val Glu Met Pro Ser  Gln Tyr Cys Leu Ala  Leu Leu Glu 
    2075                 2080                 2085             


Leu Asn  Gly Ile Gly Phe Ser  Thr Ala Glu Cys Glu  Ser Gln Lys 
    2090                 2095                 2100             


His Ile  Met Gln Ala Lys Leu  Asp Ala Ile Glu Thr  Gln Ala Tyr 
    2105                 2110                 2115             


Gln Leu  Ala Gly His Ser Phe  Ser Phe Thr Ser Ser  Asp Asp Ile 
    2120                 2125                 2130             


Ala Glu  Val Leu Phe Leu Glu  Leu Lys Leu Pro Pro  Asn Arg Glu 
    2135                 2140                 2145             


Met Lys  Asn Gln Gly Ser Lys  Lys Thr Leu Gly Ser  Thr Arg Arg 
    2150                 2155                 2160             


Gly Ile  Asp Asn Gly Arg Lys  Leu Arg Leu Gly Arg  Gln Phe Ser 
    2165                 2170                 2175             


Thr Ser  Lys Asp Val Leu Asn  Lys Leu Lys Ala Leu  His Pro Leu 
    2180                 2185                 2190             


Pro Gly  Leu Ile Leu Glu Trp  Arg Arg Ile Thr Asn  Ala Ile Thr 
    2195                 2200                 2205             


Lys Val  Val Phe Pro Leu Gln  Arg Glu Lys Cys Leu  Asn Pro Phe 
    2210                 2215                 2220             


Leu Gly  Met Glu Arg Ile Tyr  Pro Val Ser Gln Ser  His Thr Ala 
    2225                 2230                 2235             


Thr Gly  Arg Ile Thr Phe Thr  Glu Pro Asn Ile Gln  Asn Val Pro 
    2240                 2245                 2250             


Arg Asp  Phe Glu Ile Lys Met  Pro Thr Leu Val Gly  Glu Ser Pro 
    2255                 2260                 2265             


Pro Ser  Gln Ala Val Gly Lys  Gly Leu Leu Pro Met  Gly Arg Gly 
    2270                 2275                 2280             


Lys Tyr  Lys Lys Gly Phe Ser  Val Asn Pro Arg Cys  Gln Ala Gln 
    2285                 2290                 2295             


Met Glu  Glu Arg Ala Ala Asp  Arg Gly Met Pro Phe  Ser Ile Ser 
    2300                 2305                 2310             


Met Arg  His Ala Phe Val Pro  Phe Pro Gly Gly Ser  Ile Leu Ala 
    2315                 2320                 2325             


Ala Asp  Tyr Ser Gln Leu Glu  Leu Arg Ile Leu Ala  His Leu Ser 
    2330                 2335                 2340             


His Asp  Arg Arg Leu Ile Gln  Val Leu Asn Thr Gly  Ala Asp Val 
    2345                 2350                 2355             


Phe Arg  Ser Ile Ala Ala Glu  Trp Lys Met Ile Glu  Pro Glu Ser 
    2360                 2365                 2370             


Val Gly  Asp Asp Leu Arg Gln  Gln Ala Lys Gln Ile  Cys Tyr Gly 
    2375                 2380                 2385             


Ile Ile  Tyr Gly Met Gly Ala  Lys Ser Leu Gly Glu  Gln Met Gly 
    2390                 2395                 2400             


Ile Lys  Glu Asn Asp Ala Ala  Cys Tyr Ile Asp Ser  Phe Lys Ser 
    2405                 2410                 2415             


Arg Tyr  Thr Gly Ile Asn Gln  Phe Met Thr Glu Thr  Val Lys Asn 
    2420                 2425                 2430             


Cys Lys  Arg Asp Gly Phe Val  Gln Thr Ile Leu Gly  Arg Arg Arg 
    2435                 2440                 2445             


Tyr Leu  Pro Gly Ile Lys Asp  Asn Asn Pro Tyr Arg  Lys Ala His 
    2450                 2455                 2460             


Ala Glu  Arg Gln Ala Ile Asn  Thr Ile Val Gln Gly  Ser Ala Ala 
    2465                 2470                 2475             


Asp Ile  Val Lys Ile Ala Thr  Val Asn Ile Gln Lys  Gln Leu Glu 
    2480                 2485                 2490             


Thr Phe  His Ser Thr Phe Lys  Ser His Gly His Arg  Glu Gly Met 
    2495                 2500                 2505             


Leu Gln  Ser Asp Gln Thr Gly  Leu Ser Arg Lys Arg  Lys Leu Gln 
    2510                 2515                 2520             


Gly Met  Phe Cys Pro Ile Arg  Gly Gly Phe Phe Ile  Leu Gln Leu 
    2525                 2530                 2535             


His Asp  Glu Leu Leu Tyr Glu  Val Ala Glu Glu Asp  Val Val Gln 
    2540                 2545                 2550             


Val Ala  Gln Ile Val Lys Asn  Glu Met Glu Ser Ala  Val Lys Leu 
    2555                 2560                 2565             


Ser Val  Lys Leu Lys Val Lys  Val Lys Ile Gly Ala  Ser Trp Gly 
    2570                 2575                 2580             


Glu Leu  Lys Asp Phe Asp Val  
    2585                 2590 


<210>  47
<211>  919
<212>  PRT
<213>  homo sapiens

<400>  47

Met Gln Arg Ser Ile Met Ser Phe Phe His Pro Lys Lys Glu Gly Lys 
1               5                   10                  15      


Ala Lys Lys Pro Glu Lys Glu Ala Ser Asn Ser Ser Arg Glu Thr Glu 
            20                  25                  30          


Pro Pro Pro Lys Ala Ala Leu Lys Glu Trp Asn Gly Val Val Ser Glu 
        35                  40                  45              


Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg Val Leu 
    50                  55                  60                  


Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala Lys Gly 
65                  70                  75                  80  


Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg Pro Ala 
                85                  90                  95      


Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro Met Asp 
            100                 105                 110         


Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys Gln Leu 
        115                 120                 125             


Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu Asp Glu 
    130                 135                 140                 


Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Glu Thr Pro 
145                 150                 155                 160 


Lys Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu Gly Glu 
                165                 170                 175     


Asp Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr Ser Lys 
            180                 185                 190         


Ala Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr Lys 
        195                 200                 205             


Gln Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg Ala 
    210                 215                 220                 


Pro Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val Lys 
225                 230                 235                 240 


Lys Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly Ala 
                245                 250                 255     


Ala Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn Asn 
            260                 265                 270         


Tyr His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val Pro 
        275                 280                 285             


Tyr Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser Ala 
    290                 295                 300                 


Arg Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val Val 
305                 310                 315                 320 


Ala Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu Asn 
                325                 330                 335     


His Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp Gly 
            340                 345                 350         


Val Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu Ser 
        355                 360                 365             


Val Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala Glu 
    370                 375                 380                 


Asn Ser Arg Ser Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu Thr 
385                 390                 395                 400 


Ala Ser Gly Val Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr Gly 
                405                 410                 415     


Ser Ala Ser Thr Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe Val 
            420                 425                 430         


Ala Cys Arg His Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser Gly 
        435                 440                 445             


Arg Leu Arg Leu Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu Ser 
    450                 455                 460                 


Gln Ala Val Ser Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala Met 
465                 470                 475                 480 


Val Asp Ala Gly Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp Leu 
                485                 490                 495     


Glu Glu Gln Gly Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro Asp 
            500                 505                 510         


Leu Asp Arg Ile Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg Leu 
        515                 520                 525             


Pro Glu His Cys Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met Leu 
    530                 535                 540                 


Ala His Pro Thr Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu Glu 
545                 550                 555                 560 


Ala Ala Phe Thr Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln Ile 
                565                 570                 575     


His Ala Leu Glu Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln Glu 
            580                 585                 590         


Asp Asn Thr Gly Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys Ile 
        595                 600                 605             


Lys Leu Pro Ser Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val Ala 
    610                 615                 620                 


Trp Asp Arg Glu Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr Thr 
625                 630                 635                 640 


Arg Lys Arg Lys Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val Cys 
                645                 650                 655     


Leu Tyr Ala Phe Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val Arg 
            660                 665                 670         


Glu Pro Leu Ser Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val Glu 
        675                 680                 685             


Thr Glu Gly Glu Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp Ile 
    690                 695                 700                 


Glu Gln Ile Ala Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys Glu 
705                 710                 715                 720 


Gly Leu Met Val Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile Ala 
                725                 730                 735     


Lys Arg Ser His Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp Gly 
            740                 745                 750         


Val Gly Asp Thr Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly Arg 
        755                 760                 765             


Gly Lys Arg Ala Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr Asp 
    770                 775                 780                 


Glu Asp Ser Glu Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr Gly Phe 
785                 790                 795                 800 


Ser Asp Glu Glu Leu Glu Glu His His Gln Ser Leu Lys Ala Leu Val 
                805                 810                 815     


Leu Pro Ser Pro Arg Pro Tyr Val Arg Ile Asp Gly Ala Val Ile Pro 
            820                 825                 830         


Asp His Trp Leu Asp Pro Ser Ala Val Trp Glu Val Lys Cys Ala Asp 
        835                 840                 845             


Leu Ser Leu Ser Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val Asp Ser 
    850                 855                 860                 


Asp Lys Gly Ile Ser Leu Arg Phe Pro Arg Phe Ile Arg Val Arg Glu 
865                 870                 875                 880 


Asp Lys Gln Pro Glu Gln Ala Thr Thr Ser Ala Gln Val Ala Cys Leu 
                885                 890                 895     


Tyr Arg Lys Gln Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp Ser Gly 
            900                 905                 910         


Ser Asp Pro Glu Asp Thr Tyr 
        915                 


<210>  48
<211>  888
<212>  PRT
<213>  homo sapiens

<400>  48

Met Gln Arg Ser Ile Met Ala Ala Leu Lys Glu Trp Asn Gly Val Val 
1               5                   10                  15      


Ser Glu Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg 
            20                  25                  30          


Val Leu Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala 
        35                  40                  45              


Lys Gly Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg 
    50                  55                  60                  


Pro Ala Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro 
65                  70                  75                  80  


Met Asp Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys 
                85                  90                  95      


Gln Leu Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu 
            100                 105                 110         


Asp Glu Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Thr 
        115                 120                 125             


Pro Lys Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu Gly 
    130                 135                 140                 


Glu Asp Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr Ser 
145                 150                 155                 160 


Lys Ala Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr 
                165                 170                 175     


Lys Gln Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg 
            180                 185                 190         


Ala Pro Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val 
        195                 200                 205             


Lys Lys Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly 
    210                 215                 220                 


Ala Ala Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn 
225                 230                 235                 240 


Asn Tyr His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val 
                245                 250                 255     


Pro Tyr Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser 
            260                 265                 270         


Ala Arg Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val 
        275                 280                 285             


Val Ala Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu 
    290                 295                 300                 


Asn His Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp 
305                 310                 315                 320 


Gly Val Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu 
                325                 330                 335     


Ser Val Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala 
            340                 345                 350         


Glu Asn Ser Arg Ser Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu 
        355                 360                 365             


Thr Ala Ser Gly Val Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr 
    370                 375                 380                 


Gly Ser Ala Ser Thr Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe 
385                 390                 395                 400 


Val Ala Cys Arg His Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser 
                405                 410                 415     


Gly Arg Leu Arg Leu Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu 
            420                 425                 430         


Ser Gln Ala Val Ser Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala 
        435                 440                 445             


Met Val Asp Ala Gly Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp 
    450                 455                 460                 


Leu Glu Glu Gln Gly Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro 
465                 470                 475                 480 


Asp Leu Asp Arg Ile Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg 
                485                 490                 495     


Leu Pro Glu His Cys Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met 
            500                 505                 510         


Leu Ala His Pro Thr Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu 
        515                 520                 525             


Glu Ala Ala Phe Thr Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln 
    530                 535                 540                 


Ile His Ala Leu Glu Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln 
545                 550                 555                 560 


Glu Asp Asn Thr Gly Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys 
                565                 570                 575     


Ile Lys Leu Pro Ser Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val 
            580                 585                 590         


Ala Trp Asp Arg Glu Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr 
        595                 600                 605             


Thr Arg Lys Arg Lys Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val 
    610                 615                 620                 


Cys Leu Tyr Ala Phe Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val 
625                 630                 635                 640 


Arg Glu Pro Leu Ser Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val 
                645                 650                 655     


Glu Thr Glu Gly Glu Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp 
            660                 665                 670         


Ile Glu Gln Ile Ala Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys 
        675                 680                 685             


Glu Gly Leu Met Val Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile 
    690                 695                 700                 


Ala Lys Arg Ser His Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp 
705                 710                 715                 720 


Gly Val Gly Asp Thr Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly 
                725                 730                 735     


Arg Gly Lys Arg Ala Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr 
            740                 745                 750         


Asp Glu Asp Ser Glu Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr Gly 
        755                 760                 765             


Phe Ser Asp Glu Glu Leu Glu Glu His His Gln Ser Leu Lys Ala Leu 
    770                 775                 780                 


Val Leu Pro Ser Pro Arg Pro Tyr Val Arg Ile Asp Gly Ala Val Ile 
785                 790                 795                 800 


Pro Asp His Trp Leu Asp Pro Ser Ala Val Trp Glu Val Lys Cys Ala 
                805                 810                 815     


Asp Leu Ser Leu Ser Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val Asp 
            820                 825                 830         


Ser Asp Lys Gly Ile Ser Leu Arg Phe Pro Arg Phe Ile Arg Val Arg 
        835                 840                 845             


Glu Asp Lys Gln Pro Glu Gln Ala Thr Thr Ser Ala Gln Val Ala Cys 
    850                 855                 860                 


Leu Tyr Arg Lys Gln Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp Ser 
865                 870                 875                 880 


Gly Ser Asp Pro Glu Asp Thr Tyr 
                885             


<210>  49
<211>  851
<212>  PRT
<213>  homo sapiens

<400>  49

Met Gln Arg Ser Ile Met Ser Phe Phe His Pro Lys Lys Glu Gly Lys 
1               5                   10                  15      


Ala Lys Lys Pro Glu Lys Glu Ala Ser Asn Ser Ser Arg Glu Thr Glu 
            20                  25                  30          


Pro Pro Pro Lys Ala Ala Leu Lys Glu Trp Asn Gly Val Val Ser Glu 
        35                  40                  45              


Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg Val Leu 
    50                  55                  60                  


Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala Lys Gly 
65                  70                  75                  80  


Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg Pro Ala 
                85                  90                  95      


Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro Met Asp 
            100                 105                 110         


Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Glu Ala Glu Thr Pro 
        115                 120                 125             


Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr Lys Gln Glu Leu Gln 
    130                 135                 140                 


Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg Ala Pro Lys Thr Leu 
145                 150                 155                 160 


Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val Lys Lys Glu Val Lys 
                165                 170                 175     


Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly Ala Ala Glu Gly Pro 
            180                 185                 190         


Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn Asn Tyr His Pro Val 
        195                 200                 205             


Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val Pro Tyr Leu Ala Val 
    210                 215                 220                 


Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser Ala Arg Leu Arg Met 
225                 230                 235                 240 


Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val Val Ala Leu Ser Pro 
                245                 250                 255     


Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu Asn His Leu Gly Pro 
            260                 265                 270         


Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp Gly Val Leu Leu Lys 
        275                 280                 285             


Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu Ser Val Arg Ala Glu 
    290                 295                 300                 


Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala Glu Asn Ser Arg Ser 
305                 310                 315                 320 


Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu Thr Ala Ser Gly Val 
                325                 330                 335     


Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr Gly Ser Ala Ser Thr 
            340                 345                 350         


Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe Val Ala Cys Arg His 
        355                 360                 365             


Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser Gly Arg Leu Arg Leu 
    370                 375                 380                 


Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu Ser Gln Ala Val Ser 
385                 390                 395                 400 


Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala Met Val Asp Ala Gly 
                405                 410                 415     


Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp Leu Glu Glu Gln Gly 
            420                 425                 430         


Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro Asp Leu Asp Arg Ile 
        435                 440                 445             


Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg Leu Pro Glu His Cys 
    450                 455                 460                 


Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met Leu Ala His Pro Thr 
465                 470                 475                 480 


Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu Glu Ala Ala Phe Thr 
                485                 490                 495     


Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln Ile His Ala Leu Glu 
            500                 505                 510         


Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln Glu Asp Asn Thr Gly 
        515                 520                 525             


Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys Ile Lys Leu Pro Ser 
    530                 535                 540                 


Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val Ala Trp Asp Arg Glu 
545                 550                 555                 560 


Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr Thr Arg Lys Arg Lys 
                565                 570                 575     


Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val Cys Leu Tyr Ala Phe 
            580                 585                 590         


Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val Arg Glu Pro Leu Ser 
        595                 600                 605             


Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val Glu Thr Glu Gly Glu 
    610                 615                 620                 


Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp Ile Glu Gln Ile Ala 
625                 630                 635                 640 


Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys Glu Gly Leu Met Val 
                645                 650                 655     


Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile Ala Lys Arg Ser His 
            660                 665                 670         


Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp Gly Val Gly Asp Thr 
        675                 680                 685             


Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly Arg Gly Lys Arg Ala 
    690                 695                 700                 


Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr Asp Glu Asp Ser Glu 
705                 710                 715                 720 


Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr Gly Phe Ser Asp Glu Glu 
                725                 730                 735     


Leu Glu Glu His His Gln Ser Leu Lys Ala Leu Val Leu Pro Ser Pro 
            740                 745                 750         


Arg Pro Tyr Val Arg Ile Asp Gly Ala Val Ile Pro Asp His Trp Leu 
        755                 760                 765             


Asp Pro Ser Ala Val Trp Glu Val Lys Cys Ala Asp Leu Ser Leu Ser 
    770                 775                 780                 


Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val Asp Ser Asp Lys Gly Ile 
785                 790                 795                 800 


Ser Leu Arg Phe Pro Arg Phe Ile Arg Val Arg Glu Asp Lys Gln Pro 
                805                 810                 815     


Glu Gln Ala Thr Thr Ser Ala Gln Val Ala Cys Leu Tyr Arg Lys Gln 
            820                 825                 830         


Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp Ser Gly Ser Asp Pro Glu 
        835                 840                 845             


Asp Thr Tyr 
    850     


<210>  50
<211>  918
<212>  PRT
<213>  homo sapiens

<400>  50

Met Gln Arg Ser Ile Met Ser Phe Phe His Pro Lys Lys Glu Gly Lys 
1               5                   10                  15      


Ala Lys Lys Pro Glu Lys Glu Ala Ser Asn Ser Ser Arg Glu Thr Glu 
            20                  25                  30          


Pro Pro Pro Lys Ala Ala Leu Lys Glu Trp Asn Gly Val Val Ser Glu 
        35                  40                  45              


Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg Val Leu 
    50                  55                  60                  


Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala Lys Gly 
65                  70                  75                  80  


Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg Pro Ala 
                85                  90                  95      


Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro Met Asp 
            100                 105                 110         


Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys Gln Leu 
        115                 120                 125             


Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu Asp Glu 
    130                 135                 140                 


Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Thr Pro Lys 
145                 150                 155                 160 


Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu Gly Glu Asp 
                165                 170                 175     


Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr Ser Lys Ala 
            180                 185                 190         


Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr Lys Gln 
        195                 200                 205             


Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg Ala Pro 
    210                 215                 220                 


Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val Lys Lys 
225                 230                 235                 240 


Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly Ala Ala 
                245                 250                 255     


Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn Asn Tyr 
            260                 265                 270         


His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val Pro Tyr 
        275                 280                 285             


Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser Ala Arg 
    290                 295                 300                 


Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val Val Ala 
305                 310                 315                 320 


Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu Asn His 
                325                 330                 335     


Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp Gly Val 
            340                 345                 350         


Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu Ser Val 
        355                 360                 365             


Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala Glu Asn 
    370                 375                 380                 


Ser Arg Ser Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu Thr Ala 
385                 390                 395                 400 


Ser Gly Val Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr Gly Ser 
                405                 410                 415     


Ala Ser Thr Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe Val Ala 
            420                 425                 430         


Cys Arg His Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser Gly Arg 
        435                 440                 445             


Leu Arg Leu Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu Ser Gln 
    450                 455                 460                 


Ala Val Ser Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala Met Val 
465                 470                 475                 480 


Asp Ala Gly Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp Leu Glu 
                485                 490                 495     


Glu Gln Gly Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro Asp Leu 
            500                 505                 510         


Asp Arg Ile Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg Leu Pro 
        515                 520                 525             


Glu His Cys Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met Leu Ala 
    530                 535                 540                 


His Pro Thr Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu Glu Ala 
545                 550                 555                 560 


Ala Phe Thr Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln Ile His 
                565                 570                 575     


Ala Leu Glu Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln Glu Asp 
            580                 585                 590         


Asn Thr Gly Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys Ile Lys 
        595                 600                 605             


Leu Pro Ser Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val Ala Trp 
    610                 615                 620                 


Asp Arg Glu Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr Thr Arg 
625                 630                 635                 640 


Lys Arg Lys Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val Cys Leu 
                645                 650                 655     


Tyr Ala Phe Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val Arg Glu 
            660                 665                 670         


Pro Leu Ser Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val Glu Thr 
        675                 680                 685             


Glu Gly Glu Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp Ile Glu 
    690                 695                 700                 


Gln Ile Ala Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys Glu Gly 
705                 710                 715                 720 


Leu Met Val Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile Ala Lys 
                725                 730                 735     


Arg Ser His Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp Gly Val 
            740                 745                 750         


Gly Asp Thr Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly Arg Gly 
        755                 760                 765             


Lys Arg Ala Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr Asp Glu 
    770                 775                 780                 


Asp Ser Glu Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr Gly Phe Ser 
785                 790                 795                 800 


Asp Glu Glu Leu Glu Glu His His Gln Ser Leu Lys Ala Leu Val Leu 
                805                 810                 815     


Pro Ser Pro Arg Pro Tyr Val Arg Ile Asp Gly Ala Val Ile Pro Asp 
            820                 825                 830         


His Trp Leu Asp Pro Ser Ala Val Trp Glu Val Lys Cys Ala Asp Leu 
        835                 840                 845             


Ser Leu Ser Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val Asp Ser Asp 
    850                 855                 860                 


Lys Gly Ile Ser Leu Arg Phe Pro Arg Phe Ile Arg Val Arg Glu Asp 
865                 870                 875                 880 


Lys Gln Pro Glu Gln Ala Thr Thr Ser Ala Gln Val Ala Cys Leu Tyr 
                885                 890                 895     


Arg Lys Gln Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp Ser Gly Ser 
            900                 905                 910         


Asp Pro Glu Asp Thr Tyr 
        915             


<210>  51
<211>  889
<212>  PRT
<213>  homo sapiens

<400>  51

Met Gln Arg Ser Ile Met Ala Ala Leu Lys Glu Trp Asn Gly Val Val 
1               5                   10                  15      


Ser Glu Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg 
            20                  25                  30          


Val Leu Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala 
        35                  40                  45              


Lys Gly Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg 
    50                  55                  60                  


Pro Ala Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro 
65                  70                  75                  80  


Met Asp Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys 
                85                  90                  95      


Gln Leu Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu 
            100                 105                 110         


Asp Glu Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Glu Glu 
        115                 120                 125             


Thr Pro Lys Glu Ser Leu Thr Glu Ala Glu Val Ala Thr Glu Lys Glu 
    130                 135                 140                 


Gly Glu Asp Gly Asp Gln Pro Thr Thr Pro Pro Lys Pro Leu Lys Thr 
145                 150                 155                 160 


Ser Lys Ala Glu Thr Pro Thr Glu Ser Val Ser Glu Pro Glu Val Ala 
                165                 170                 175     


Thr Lys Gln Glu Leu Gln Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg 
            180                 185                 190         


Arg Ala Pro Lys Thr Leu Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala 
        195                 200                 205             


Val Lys Lys Glu Val Lys Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu 
    210                 215                 220                 


Gly Ala Ala Glu Gly Pro Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys 
225                 230                 235                 240 


Asn Asn Tyr His Pro Val Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys 
                245                 250                 255     


Val Pro Tyr Leu Ala Val Ala Arg Thr Phe Glu Lys Ile Glu Glu Val 
            260                 265                 270         


Ser Ala Arg Leu Arg Met Val Glu Thr Leu Ser Asn Leu Leu Arg Ser 
        275                 280                 285             


Val Val Ala Leu Ser Pro Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser 
    290                 295                 300                 


Leu Asn His Leu Gly Pro Pro Gln Gln Gly Leu Glu Leu Gly Val Gly 
305                 310                 315                 320 


Asp Gly Val Leu Leu Lys Ala Val Ala Gln Ala Thr Gly Arg Gln Leu 
                325                 330                 335     


Glu Ser Val Arg Ala Glu Ala Ala Glu Lys Gly Asp Val Gly Leu Val 
            340                 345                 350         


Ala Glu Asn Ser Arg Ser Thr Gln Arg Leu Met Leu Pro Pro Pro Pro 
        355                 360                 365             


Leu Thr Ala Ser Gly Val Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu 
    370                 375                 380                 


Thr Gly Ser Ala Ser Thr Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu 
385                 390                 395                 400 


Phe Val Ala Cys Arg His Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu 
                405                 410                 415     


Ser Gly Arg Leu Arg Leu Gly Leu Ala Glu Gln Ser Val Leu Ala Ala 
            420                 425                 430         


Leu Ser Gln Ala Val Ser Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro 
        435                 440                 445             


Ala Met Val Asp Ala Gly Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr 
    450                 455                 460                 


Trp Leu Glu Glu Gln Gly Met Ile Leu Lys Gln Thr Phe Cys Glu Val 
465                 470                 475                 480 


Pro Asp Leu Asp Arg Ile Ile Pro Val Leu Leu Glu His Gly Leu Glu 
                485                 490                 495     


Arg Leu Pro Glu His Cys Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro 
            500                 505                 510         


Met Leu Ala His Pro Thr Arg Gly Ile Ser Glu Val Leu Lys Arg Phe 
        515                 520                 525             


Glu Glu Ala Ala Phe Thr Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala 
    530                 535                 540                 


Gln Ile His Ala Leu Glu Gly Gly Glu Val Lys Ile Phe Ser Arg Asn 
545                 550                 555                 560 


Gln Glu Asp Asn Thr Gly Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro 
                565                 570                 575     


Lys Ile Lys Leu Pro Ser Val Thr Ser Phe Ile Leu Asp Thr Glu Ala 
            580                 585                 590         


Val Ala Trp Asp Arg Glu Lys Lys Gln Ile Gln Pro Phe Gln Val Leu 
        595                 600                 605             


Thr Thr Arg Lys Arg Lys Glu Val Asp Ala Ser Glu Ile Gln Val Gln 
    610                 615                 620                 


Val Cys Leu Tyr Ala Phe Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu 
625                 630                 635                 640 


Val Arg Glu Pro Leu Ser Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe 
                645                 650                 655     


Val Glu Thr Glu Gly Glu Phe Val Phe Ala Thr Ser Leu Asp Thr Lys 
            660                 665                 670         


Asp Ile Glu Gln Ile Ala Glu Phe Leu Glu Gln Ser Val Lys Asp Ser 
        675                 680                 685             


Cys Glu Gly Leu Met Val Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu 
    690                 695                 700                 


Ile Ala Lys Arg Ser His Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu 
705                 710                 715                 720 


Asp Gly Val Gly Asp Thr Leu Asp Leu Val Val Ile Gly Ala Tyr Leu 
                725                 730                 735     


Gly Arg Gly Lys Arg Ala Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser 
            740                 745                 750         


Tyr Asp Glu Asp Ser Glu Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr 
        755                 760                 765             


Gly Phe Ser Asp Glu Glu Leu Glu Glu His His Gln Ser Leu Lys Ala 
    770                 775                 780                 


Leu Val Leu Pro Ser Pro Arg Pro Tyr Val Arg Ile Asp Gly Ala Val 
785                 790                 795                 800 


Ile Pro Asp His Trp Leu Asp Pro Ser Ala Val Trp Glu Val Lys Cys 
                805                 810                 815     


Ala Asp Leu Ser Leu Ser Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val 
            820                 825                 830         


Asp Ser Asp Lys Gly Ile Ser Leu Arg Phe Pro Arg Phe Ile Arg Val 
        835                 840                 845             


Arg Glu Asp Lys Gln Pro Glu Gln Ala Thr Thr Ser Ala Gln Val Ala 
    850                 855                 860                 


Cys Leu Tyr Arg Lys Gln Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp 
865                 870                 875                 880 


Ser Gly Ser Asp Pro Glu Asp Thr Tyr 
                885                 


<210>  52
<211>  883
<212>  PRT
<213>  homo sapiens

<400>  52

Met Gln Arg Ser Ile Met Ser Phe Phe His Pro Lys Lys Glu Gly Lys 
1               5                   10                  15      


Ala Lys Lys Pro Glu Lys Glu Ala Ser Asn Ser Ser Arg Glu Thr Glu 
            20                  25                  30          


Pro Pro Pro Lys Ala Ala Leu Lys Glu Trp Asn Gly Val Val Ser Glu 
        35                  40                  45              


Ser Asp Ser Pro Val Lys Arg Pro Gly Arg Lys Ala Ala Arg Val Leu 
    50                  55                  60                  


Gly Ser Glu Gly Glu Glu Glu Asp Glu Ala Leu Ser Pro Ala Lys Gly 
65                  70                  75                  80  


Gln Lys Pro Ala Leu Asp Cys Ser Gln Val Ser Pro Pro Arg Pro Ala 
                85                  90                  95      


Thr Ser Pro Glu Asn Asn Ala Ser Leu Ser Asp Thr Ser Pro Met Asp 
            100                 105                 110         


Ser Ser Pro Ser Gly Ile Pro Lys Arg Arg Thr Ala Arg Lys Gln Leu 
        115                 120                 125             


Pro Lys Arg Thr Ile Gln Glu Val Leu Glu Glu Gln Ser Glu Asp Glu 
    130                 135                 140                 


Asp Arg Glu Ala Lys Arg Lys Lys Glu Glu Glu Glu Ala Glu Thr Pro 
145                 150                 155                 160 


Thr Glu Ser Val Ser Glu Pro Glu Val Ala Thr Lys Gln Glu Leu Gln 
                165                 170                 175     


Glu Glu Glu Glu Gln Thr Lys Pro Pro Arg Arg Ala Pro Lys Thr Leu 
            180                 185                 190         


Ser Ser Phe Phe Thr Pro Arg Lys Pro Ala Val Lys Lys Glu Val Lys 
        195                 200                 205             


Glu Glu Glu Pro Gly Ala Pro Gly Lys Glu Gly Ala Ala Glu Gly Pro 
    210                 215                 220                 


Leu Asp Pro Ser Gly Tyr Asn Pro Ala Lys Asn Asn Tyr His Pro Val 
225                 230                 235                 240 


Glu Asp Ala Cys Trp Lys Pro Gly Gln Lys Val Pro Tyr Leu Ala Val 
                245                 250                 255     


Ala Arg Thr Phe Glu Lys Ile Glu Glu Val Ser Ala Arg Leu Arg Met 
            260                 265                 270         


Val Glu Thr Leu Ser Asn Leu Leu Arg Ser Val Val Ala Leu Ser Pro 
        275                 280                 285             


Pro Asp Leu Leu Pro Val Leu Tyr Leu Ser Leu Asn His Leu Gly Pro 
    290                 295                 300                 


Pro Gln Gln Gly Leu Glu Leu Gly Val Gly Asp Gly Val Leu Leu Lys 
305                 310                 315                 320 


Ala Val Ala Gln Ala Thr Gly Arg Gln Leu Glu Ser Val Arg Ala Glu 
                325                 330                 335     


Ala Ala Glu Lys Gly Asp Val Gly Leu Val Ala Glu Asn Ser Arg Ser 
            340                 345                 350         


Thr Gln Arg Leu Met Leu Pro Pro Pro Pro Leu Thr Ala Ser Gly Val 
        355                 360                 365             


Phe Ser Lys Phe Arg Asp Ile Ala Arg Leu Thr Gly Ser Ala Ser Thr 
    370                 375                 380                 


Ala Lys Lys Ile Asp Ile Ile Lys Gly Leu Phe Val Ala Cys Arg His 
385                 390                 395                 400 


Ser Glu Ala Arg Phe Ile Ala Arg Ser Leu Ser Gly Arg Leu Arg Leu 
                405                 410                 415     


Gly Leu Ala Glu Gln Ser Val Leu Ala Ala Leu Ser Gln Ala Val Ser 
            420                 425                 430         


Leu Thr Pro Pro Gly Gln Glu Phe Pro Pro Ala Met Val Asp Ala Gly 
        435                 440                 445             


Lys Gly Lys Thr Ala Glu Ala Arg Lys Thr Trp Leu Glu Glu Gln Gly 
    450                 455                 460                 


Met Ile Leu Lys Gln Thr Phe Cys Glu Val Pro Asp Leu Asp Arg Ile 
465                 470                 475                 480 


Ile Pro Val Leu Leu Glu His Gly Leu Glu Arg Leu Pro Glu His Cys 
                485                 490                 495     


Lys Leu Ser Pro Gly Ile Pro Leu Lys Pro Met Leu Ala His Pro Thr 
            500                 505                 510         


Arg Gly Ile Ser Glu Val Leu Lys Arg Phe Glu Glu Ala Ala Phe Thr 
        515                 520                 525             


Cys Glu Tyr Lys Tyr Asp Gly Gln Arg Ala Gln Ile His Ala Leu Glu 
    530                 535                 540                 


Gly Gly Glu Val Lys Ile Phe Ser Arg Asn Gln Glu Asp Asn Thr Gly 
545                 550                 555                 560 


Lys Tyr Pro Asp Ile Ile Ser Arg Ile Pro Lys Ile Lys Leu Pro Ser 
                565                 570                 575     


Val Thr Ser Phe Ile Leu Asp Thr Glu Ala Val Ala Trp Asp Arg Glu 
            580                 585                 590         


Lys Lys Gln Ile Gln Pro Phe Gln Val Leu Thr Thr Arg Lys Arg Lys 
        595                 600                 605             


Glu Val Asp Ala Ser Glu Ile Gln Val Gln Val Cys Leu Tyr Ala Phe 
    610                 615                 620                 


Asp Leu Ile Tyr Leu Asn Gly Glu Ser Leu Val Arg Glu Pro Leu Ser 
625                 630                 635                 640 


Arg Arg Arg Gln Leu Leu Arg Glu Asn Phe Val Glu Thr Glu Gly Glu 
                645                 650                 655     


Phe Val Phe Ala Thr Ser Leu Asp Thr Lys Asp Ile Glu Gln Ile Ala 
            660                 665                 670         


Glu Phe Leu Glu Gln Ser Val Lys Asp Ser Cys Glu Gly Leu Met Val 
        675                 680                 685             


Lys Thr Leu Asp Val Asp Ala Thr Tyr Glu Ile Ala Lys Arg Ser His 
    690                 695                 700                 


Asn Trp Leu Lys Leu Lys Lys Asp Tyr Leu Asp Gly Val Gly Asp Thr 
705                 710                 715                 720 


Leu Asp Leu Val Val Ile Gly Ala Tyr Leu Gly Arg Gly Lys Arg Ala 
                725                 730                 735     


Gly Arg Tyr Gly Gly Phe Leu Leu Ala Ser Tyr Asp Glu Asp Ser Glu 
            740                 745                 750         


Glu Leu Gln Ala Ile Cys Lys Leu Gly Thr Gly Phe Ser Asp Glu Glu 
        755                 760                 765             


Leu Glu Glu His His Gln Ser Leu Lys Ala Leu Val Leu Pro Ser Pro 
    770                 775                 780                 


Arg Pro Tyr Val Arg Ile Asp Gly Ala Val Ile Pro Asp His Trp Leu 
785                 790                 795                 800 


Asp Pro Ser Ala Val Trp Glu Val Lys Cys Ala Asp Leu Ser Leu Ser 
                805                 810                 815     


Pro Ile Tyr Pro Ala Ala Arg Gly Leu Val Asp Ser Asp Lys Gly Ile 
            820                 825                 830         


Ser Leu Arg Phe Pro Arg Phe Ile Arg Val Arg Glu Asp Lys Gln Pro 
        835                 840                 845             


Glu Gln Ala Thr Thr Ser Ala Gln Val Ala Cys Leu Tyr Arg Lys Gln 
    850                 855                 860                 


Ser Gln Ile Gln Asn Gln Gln Gly Glu Asp Ser Gly Ser Asp Pro Glu 
865                 870                 875                 880 


Asp Thr Tyr 
            


<210>  53
<211>  1009
<212>  PRT
<213>  homo sapiens

<400>  53

Met Ser Leu Ala Phe Lys Ile Phe Phe Pro Gln Thr Leu Arg Ala Leu 
1               5                   10                  15      


Ser Arg Lys Glu Leu Cys Leu Phe Arg Lys His His Trp Arg Asp Val 
            20                  25                  30          


Arg Gln Phe Ser Gln Trp Ser Glu Thr Asp Leu Leu His Gly His Pro 
        35                  40                  45              


Leu Phe Leu Arg Arg Lys Pro Val Leu Ser Phe Gln Gly Ser His Leu 
    50                  55                  60                  


Arg Ser Arg Ala Thr Tyr Leu Val Phe Leu Pro Gly Leu His Val Gly 
65                  70                  75                  80  


Leu Cys Ser Gly Pro Cys Glu Met Ala Glu Gln Arg Phe Cys Val Asp 
                85                  90                  95      


Tyr Ala Lys Arg Gly Thr Ala Gly Cys Lys Lys Cys Lys Glu Lys Ile 
            100                 105                 110         


Val Lys Gly Val Cys Arg Ile Gly Lys Val Val Pro Asn Pro Phe Ser 
        115                 120                 125             


Glu Ser Gly Gly Asp Met Lys Glu Trp Tyr His Ile Lys Cys Met Phe 
    130                 135                 140                 


Glu Lys Leu Glu Arg Ala Arg Ala Thr Thr Lys Lys Ile Glu Asp Leu 
145                 150                 155                 160 


Thr Glu Leu Glu Gly Trp Glu Glu Leu Glu Asp Asn Glu Lys Glu Gln 
                165                 170                 175     


Ile Thr Gln His Ile Ala Asp Leu Ser Ser Lys Ala Ala Gly Thr Pro 
            180                 185                 190         


Lys Lys Lys Ala Val Val Gln Ala Lys Leu Thr Thr Thr Gly Gln Val 
        195                 200                 205             


Thr Ser Pro Val Lys Gly Ala Ser Phe Val Thr Ser Thr Asn Pro Arg 
    210                 215                 220                 


Lys Phe Ser Gly Phe Ser Ala Lys Pro Asn Asn Ser Gly Glu Ala Pro 
225                 230                 235                 240 


Ser Ser Pro Thr Pro Lys Arg Ser Leu Ser Ser Ser Lys Cys Asp Pro 
                245                 250                 255     


Arg His Lys Asp Cys Leu Leu Arg Glu Phe Arg Lys Leu Cys Ala Met 
            260                 265                 270         


Val Ala Asp Asn Pro Ser Tyr Asn Thr Lys Thr Gln Ile Ile Gln Asp 
        275                 280                 285             


Phe Leu Arg Lys Gly Ser Ala Gly Asp Gly Phe His Gly Asp Val Tyr 
    290                 295                 300                 


Leu Thr Val Lys Leu Leu Leu Pro Gly Val Ile Lys Thr Val Tyr Asn 
305                 310                 315                 320 


Leu Asn Asp Lys Gln Ile Val Lys Leu Phe Ser Arg Ile Phe Asn Cys 
                325                 330                 335     


Asn Pro Asp Asp Met Ala Arg Asp Leu Glu Gln Gly Asp Val Ser Glu 
            340                 345                 350         


Thr Ile Arg Val Phe Phe Glu Gln Ser Lys Ser Phe Pro Pro Ala Ala 
        355                 360                 365             


Lys Ser Leu Leu Thr Ile Gln Glu Val Asp Glu Phe Leu Leu Arg Leu 
    370                 375                 380                 


Ser Lys Leu Thr Lys Glu Asp Glu Gln Gln Gln Ala Leu Gln Asp Ile 
385                 390                 395                 400 


Ala Ser Arg Cys Thr Ala Asn Asp Leu Lys Cys Ile Ile Arg Leu Ile 
                405                 410                 415     


Lys His Asp Leu Lys Met Asn Ser Gly Ala Lys His Val Leu Asp Ala 
            420                 425                 430         


Leu Asp Pro Asn Ala Tyr Glu Ala Phe Lys Ala Ser Arg Asn Leu Gln 
        435                 440                 445             


Asp Val Val Glu Arg Val Leu His Asn Ala Gln Glu Val Glu Lys Glu 
    450                 455                 460                 


Pro Gly Gln Arg Arg Ala Leu Ser Val Gln Ala Ser Leu Met Thr Pro 
465                 470                 475                 480 


Val Gln Pro Met Leu Ala Glu Ala Cys Lys Ser Val Glu Tyr Ala Met 
                485                 490                 495     


Lys Lys Cys Pro Asn Gly Met Phe Ser Glu Ile Lys Tyr Asp Gly Glu 
            500                 505                 510         


Arg Val Gln Val His Lys Asn Gly Asp His Phe Ser Tyr Phe Ser Arg 
        515                 520                 525             


Ser Leu Lys Pro Val Leu Pro His Lys Val Ala His Phe Lys Asp Tyr 
    530                 535                 540                 


Ile Pro Gln Ala Phe Pro Gly Gly His Ser Met Ile Leu Asp Ser Glu 
545                 550                 555                 560 


Val Leu Leu Ile Asp Asn Lys Thr Gly Lys Pro Leu Pro Phe Gly Thr 
                565                 570                 575     


Leu Gly Val His Lys Lys Ala Ala Phe Gln Asp Ala Asn Val Cys Leu 
            580                 585                 590         


Phe Val Phe Asp Cys Ile Tyr Phe Asn Asp Val Ser Leu Met Asp Arg 
        595                 600                 605             


Pro Leu Cys Glu Arg Arg Lys Phe Leu His Asp Asn Met Val Glu Ile 
    610                 615                 620                 


Pro Asn Arg Ile Met Phe Ser Glu Met Lys Arg Val Thr Lys Ala Leu 
625                 630                 635                 640 


Asp Leu Ala Asp Met Ile Thr Arg Val Ile Gln Glu Gly Leu Glu Gly 
                645                 650                 655     


Leu Val Leu Lys Asp Val Lys Gly Thr Tyr Glu Pro Gly Lys Arg His 
            660                 665                 670         


Trp Leu Lys Val Lys Lys Asp Tyr Leu Asn Glu Gly Ala Met Ala Asp 
        675                 680                 685             


Thr Ala Asp Leu Val Val Leu Gly Ala Phe Tyr Gly Gln Gly Ser Lys 
    690                 695                 700                 


Gly Gly Met Met Ser Ile Phe Leu Met Gly Cys Tyr Asp Pro Gly Ser 
705                 710                 715                 720 


Gln Lys Trp Cys Thr Val Thr Lys Cys Ala Gly Gly His Asp Asp Ala 
                725                 730                 735     


Thr Leu Ala Arg Leu Gln Asn Glu Leu Asp Met Val Lys Ile Ser Lys 
            740                 745                 750         


Asp Pro Ser Lys Ile Pro Ser Trp Leu Lys Val Asn Lys Ile Tyr Tyr 
        755                 760                 765             


Pro Asp Phe Ile Val Pro Asp Pro Lys Lys Ala Ala Val Trp Glu Ile 
    770                 775                 780                 


Thr Gly Ala Glu Phe Ser Lys Ser Glu Ala His Thr Ala Asp Gly Ile 
785                 790                 795                 800 


Ser Ile Arg Phe Pro Arg Cys Thr Arg Ile Arg Asp Asp Lys Asp Trp 
                805                 810                 815     


Lys Ser Ala Thr Asn Leu Pro Gln Leu Lys Glu Leu Tyr Gln Leu Ser 
            820                 825                 830         


Lys Glu Lys Ala Asp Phe Thr Val Val Ala Gly Asp Glu Gly Ser Ser 
        835                 840                 845             


Thr Thr Gly Gly Ser Ser Glu Glu Asn Lys Gly Pro Ser Gly Ser Ala 
    850                 855                 860                 


Val Ser Arg Lys Ala Pro Ser Lys Pro Ser Ala Ser Thr Lys Lys Ala 
865                 870                 875                 880 


Glu Gly Lys Leu Ser Asn Ser Asn Ser Lys Asp Gly Asn Met Gln Thr 
                885                 890                 895     


Ala Lys Pro Ser Ala Met Lys Val Gly Glu Lys Leu Ala Thr Lys Ser 
            900                 905                 910         


Ser Pro Val Lys Val Gly Glu Lys Arg Lys Ala Ala Asp Glu Thr Leu 
        915                 920                 925             


Cys Gln Thr Lys Val Leu Leu Asp Ile Phe Thr Gly Val Arg Leu Tyr 
    930                 935                 940                 


Leu Pro Pro Ser Thr Pro Asp Phe Ser Arg Leu Arg Arg Tyr Phe Val 
945                 950                 955                 960 


Ala Phe Asp Gly Asp Leu Val Gln Glu Phe Asp Met Thr Ser Ala Thr 
                965                 970                 975     


His Val Leu Gly Ser Arg Asp Lys Asn Pro Ala Ala Gln Gln Val Ser 
            980                 985                 990         


Pro Glu Trp Ile Trp Ala Cys Ile  Arg Lys Arg Arg Leu  Val Ala Pro 
        995                 1000                 1005             


Cys 
    


<210>  54
<211>  949
<212>  PRT
<213>  homo sapiens

<400>  54

Met Ser Leu Ala Phe Lys Ile Phe Phe Pro Gln Thr Leu Arg Ala Leu 
1               5                   10                  15      


Ser Arg Lys Glu Leu Cys Leu Phe Arg Lys His His Trp Arg Asp Val 
            20                  25                  30          


Arg Gln Phe Ser Gln Trp Ser Glu Thr Asp Leu Leu His Gly His Pro 
        35                  40                  45              


Leu Phe Leu Arg Arg Lys Pro Val Leu Ser Phe Gln Gly Ser His Leu 
    50                  55                  60                  


Arg Ser Arg Ala Thr Tyr Leu Val Phe Leu Pro Gly Leu His Val Gly 
65                  70                  75                  80  


Leu Cys Ser Gly Pro Cys Glu Met Ala Glu Gln Arg Phe Cys Val Asp 
                85                  90                  95      


Tyr Ala Lys Arg Gly Thr Ala Gly Cys Lys Lys Cys Lys Glu Lys Ile 
            100                 105                 110         


Val Lys Gly Val Cys Arg Ile Gly Lys Val Val Pro Asn Pro Phe Ser 
        115                 120                 125             


Glu Ser Gly Gly Asp Met Lys Glu Trp Tyr His Ile Lys Cys Met Phe 
    130                 135                 140                 


Glu Lys Leu Glu Arg Ala Arg Ala Thr Thr Lys Lys Ile Glu Asp Leu 
145                 150                 155                 160 


Thr Glu Leu Glu Gly Trp Glu Glu Leu Glu Asp Asn Glu Lys Glu Gln 
                165                 170                 175     


Ile Thr Gln His Ile Ala Asp Leu Ser Ser Lys Ala Ala Gly Thr Pro 
            180                 185                 190         


Lys Lys Lys Ala Val Val Gln Ala Lys Leu Thr Thr Thr Gly Gln Val 
        195                 200                 205             


Thr Ser Pro Val Lys Gly Ala Ser Phe Val Thr Ser Thr Asn Pro Arg 
    210                 215                 220                 


Lys Phe Ser Gly Phe Ser Ala Lys Pro Asn Asn Ser Gly Glu Ala Pro 
225                 230                 235                 240 


Ser Ser Pro Thr Pro Lys Arg Ser Leu Ser Ser Ser Lys Cys Asp Pro 
                245                 250                 255     


Arg His Lys Asp Cys Leu Leu Arg Glu Phe Arg Lys Leu Cys Ala Met 
            260                 265                 270         


Val Ala Asp Asn Pro Ser Tyr Asn Thr Lys Thr Gln Ile Ile Gln Asp 
        275                 280                 285             


Phe Leu Arg Lys Gly Ser Ala Gly Asp Gly Phe His Gly Asp Val Tyr 
    290                 295                 300                 


Leu Thr Val Lys Leu Leu Leu Pro Gly Val Ile Lys Thr Val Tyr Asn 
305                 310                 315                 320 


Leu Asn Asp Lys Gln Ile Val Lys Leu Phe Ser Arg Ile Phe Asn Cys 
                325                 330                 335     


Asn Pro Asp Asp Met Ala Arg Asp Leu Glu Gln Gly Asp Val Ser Glu 
            340                 345                 350         


Thr Ile Arg Val Phe Phe Glu Gln Ser Lys Ser Phe Pro Pro Ala Ala 
        355                 360                 365             


Lys Ser Leu Leu Thr Ile Gln Glu Val Asp Glu Phe Leu Leu Arg Leu 
    370                 375                 380                 


Ser Lys Leu Thr Lys Glu Asp Glu Gln Gln Gln Ala Leu Gln Asp Ile 
385                 390                 395                 400 


Ala Ser Arg Cys Thr Ala Asn Asp Leu Lys Cys Ile Ile Arg Leu Ile 
                405                 410                 415     


Lys His Asp Leu Lys Met Asn Ser Gly Ala Lys His Val Leu Asp Ala 
            420                 425                 430         


Leu Asp Pro Asn Ala Tyr Glu Ala Phe Lys Ala Ser Arg Asn Leu Gln 
        435                 440                 445             


Asp Val Val Glu Arg Val Leu His Asn Ala Gln Glu Val Glu Lys Glu 
    450                 455                 460                 


Pro Gly Gln Arg Arg Ala Leu Ser Val Gln Ala Ser Leu Met Thr Pro 
465                 470                 475                 480 


Val Gln Pro Met Leu Ala Glu Ala Cys Lys Ser Val Glu Tyr Ala Met 
                485                 490                 495     


Lys Lys Cys Pro Asn Gly Met Phe Ser Glu Ile Lys Tyr Asp Gly Glu 
            500                 505                 510         


Arg Val Gln Val His Lys Asn Gly Asp His Phe Ser Tyr Phe Ser Arg 
        515                 520                 525             


Ser Leu Lys Pro Val Leu Pro His Lys Val Ala His Phe Lys Asp Tyr 
    530                 535                 540                 


Ile Pro Gln Ala Phe Pro Gly Gly His Ser Met Ile Leu Asp Ser Glu 
545                 550                 555                 560 


Val Leu Leu Ile Asp Asn Lys Thr Gly Lys Pro Leu Pro Phe Gly Thr 
                565                 570                 575     


Leu Gly Val His Lys Lys Ala Ala Phe Gln Asp Ala Asn Val Cys Leu 
            580                 585                 590         


Phe Val Phe Asp Cys Ile Tyr Phe Asn Asp Val Ser Leu Met Asp Arg 
        595                 600                 605             


Pro Leu Cys Glu Arg Arg Lys Phe Leu His Asp Asn Met Val Glu Ile 
    610                 615                 620                 


Pro Asn Arg Ile Met Phe Ser Glu Met Lys Arg Val Thr Lys Ala Leu 
625                 630                 635                 640 


Asp Leu Ala Asp Met Ile Thr Arg Val Ile Gln Glu Gly Leu Glu Gly 
                645                 650                 655     


Leu Val Leu Lys Asp Val Lys Gly Thr Tyr Glu Pro Gly Lys Arg His 
            660                 665                 670         


Trp Leu Lys Val Lys Lys Asp Tyr Leu Asn Glu Gly Ala Met Ala Asp 
        675                 680                 685             


Thr Ala Asp Leu Val Val Leu Gly Ala Phe Tyr Gly Gln Gly Ser Lys 
    690                 695                 700                 


Gly Gly Met Met Ser Ile Phe Leu Met Gly Cys Tyr Asp Pro Gly Ser 
705                 710                 715                 720 


Gln Lys Trp Cys Thr Val Thr Lys Cys Ala Gly Gly His Asp Asp Ala 
                725                 730                 735     


Thr Leu Ala Arg Leu Gln Asn Glu Leu Asp Met Val Lys Ile Ser Lys 
            740                 745                 750         


Asp Pro Ser Lys Ile Pro Ser Trp Leu Lys Val Asn Lys Ile Tyr Tyr 
        755                 760                 765             


Pro Asp Phe Ile Val Pro Asp Pro Lys Lys Ala Ala Val Trp Glu Ile 
    770                 775                 780                 


Thr Gly Ala Glu Phe Ser Lys Ser Glu Ala His Thr Ala Asp Gly Ile 
785                 790                 795                 800 


Ser Ile Arg Phe Pro Arg Cys Thr Arg Ile Arg Asp Asp Lys Asp Trp 
                805                 810                 815     


Lys Ser Ala Thr Asn Leu Pro Gln Leu Lys Glu Leu Tyr Gln Leu Ser 
            820                 825                 830         


Lys Glu Lys Ala Asp Phe Thr Val Val Ala Gly Asp Glu Gly Ser Ser 
        835                 840                 845             


Thr Thr Gly Gly Ser Ser Glu Glu Asn Lys Gly Pro Ser Gly Ser Ala 
    850                 855                 860                 


Val Ser Arg Lys Ala Pro Ser Lys Pro Ser Ala Ser Thr Lys Lys Ala 
865                 870                 875                 880 


Glu Gly Lys Leu Ser Asn Ser Asn Ser Lys Asp Gly Asn Met Gln Thr 
                885                 890                 895     


Ala Lys Pro Ser Ala Met Lys Val Gly Glu Lys Leu Ala Thr Lys Ser 
            900                 905                 910         


Ser Pro Val Lys Val Gly Glu Lys Arg Lys Ala Ala Asp Glu Thr Leu 
        915                 920                 925             


Cys Gln Thr Lys Arg Arg Pro Ala Ser Glu Gln Arg Gly Arg Thr Val 
    930                 935                 940                 


Pro Ala Gly Arg Arg 
945                 


<210>  55
<211>  1018
<212>  PRT
<213>  homo sapiens

<400>  55

Met Ser Lys Phe Arg Gly Leu Arg Tyr Met Ser Leu Ala Phe Lys Ile 
1               5                   10                  15      


Phe Phe Pro Gln Thr Leu Arg Ala Leu Ser Arg Lys Glu Leu Cys Leu 
            20                  25                  30          


Phe Arg Lys His His Trp Arg Asp Val Arg Gln Phe Ser Gln Trp Ser 
        35                  40                  45              


Glu Thr Asp Leu Leu His Gly His Pro Leu Phe Leu Arg Arg Lys Pro 
    50                  55                  60                  


Val Leu Ser Phe Gln Gly Ser His Leu Arg Ser Arg Ala Thr Tyr Leu 
65                  70                  75                  80  


Val Phe Leu Pro Gly Leu His Val Gly Leu Cys Ser Gly Pro Cys Glu 
                85                  90                  95      


Met Ala Glu Gln Arg Phe Cys Val Asp Tyr Ala Lys Arg Gly Thr Ala 
            100                 105                 110         


Gly Cys Lys Lys Cys Lys Glu Lys Ile Val Lys Gly Val Cys Arg Ile 
        115                 120                 125             


Gly Lys Val Val Pro Asn Pro Phe Ser Glu Ser Gly Gly Asp Met Lys 
    130                 135                 140                 


Glu Trp Tyr His Ile Lys Cys Met Phe Glu Lys Leu Glu Arg Ala Arg 
145                 150                 155                 160 


Ala Thr Thr Lys Lys Ile Glu Asp Leu Thr Glu Leu Glu Gly Trp Glu 
                165                 170                 175     


Glu Leu Glu Asp Asn Glu Lys Glu Gln Ile Thr Gln His Ile Ala Asp 
            180                 185                 190         


Leu Ser Ser Lys Ala Ala Gly Thr Pro Lys Lys Lys Ala Val Val Gln 
        195                 200                 205             


Ala Lys Leu Thr Thr Thr Gly Gln Val Thr Ser Pro Val Lys Gly Ala 
    210                 215                 220                 


Ser Phe Val Thr Ser Thr Asn Pro Arg Lys Phe Ser Gly Phe Ser Ala 
225                 230                 235                 240 


Lys Pro Asn Asn Ser Gly Glu Ala Pro Ser Ser Pro Thr Pro Lys Arg 
                245                 250                 255     


Ser Leu Ser Ser Ser Lys Cys Asp Pro Arg His Lys Asp Cys Leu Leu 
            260                 265                 270         


Arg Glu Phe Arg Lys Leu Cys Ala Met Val Ala Asp Asn Pro Ser Tyr 
        275                 280                 285             


Asn Thr Lys Thr Gln Ile Ile Gln Asp Phe Leu Arg Lys Gly Ser Ala 
    290                 295                 300                 


Gly Asp Gly Phe His Gly Asp Val Tyr Leu Thr Val Lys Leu Leu Leu 
305                 310                 315                 320 


Pro Gly Val Ile Lys Thr Val Tyr Asn Leu Asn Asp Lys Gln Ile Val 
                325                 330                 335     


Lys Leu Phe Ser Arg Ile Phe Asn Cys Asn Pro Asp Asp Met Ala Arg 
            340                 345                 350         


Asp Leu Glu Gln Gly Asp Val Ser Glu Thr Ile Arg Val Phe Phe Glu 
        355                 360                 365             


Gln Ser Lys Ser Phe Pro Pro Ala Ala Lys Ser Leu Leu Thr Ile Gln 
    370                 375                 380                 


Glu Val Asp Glu Phe Leu Leu Arg Leu Ser Lys Leu Thr Lys Glu Asp 
385                 390                 395                 400 


Glu Gln Gln Gln Ala Leu Gln Asp Ile Ala Ser Arg Cys Thr Ala Asn 
                405                 410                 415     


Asp Leu Lys Cys Ile Ile Arg Leu Ile Lys His Asp Leu Lys Met Asn 
            420                 425                 430         


Ser Gly Ala Lys His Val Leu Asp Ala Leu Asp Pro Asn Ala Tyr Glu 
        435                 440                 445             


Ala Phe Lys Ala Ser Arg Asn Leu Gln Asp Val Val Glu Arg Val Leu 
    450                 455                 460                 


His Asn Ala Gln Glu Val Glu Lys Glu Pro Gly Gln Arg Arg Ala Leu 
465                 470                 475                 480 


Ser Val Gln Ala Ser Leu Met Thr Pro Val Gln Pro Met Leu Ala Glu 
                485                 490                 495     


Ala Cys Lys Ser Val Glu Tyr Ala Met Lys Lys Cys Pro Asn Gly Met 
            500                 505                 510         


Phe Ser Glu Ile Lys Tyr Asp Gly Glu Arg Val Gln Val His Lys Asn 
        515                 520                 525             


Gly Asp His Phe Ser Tyr Phe Ser Arg Ser Leu Lys Pro Val Leu Pro 
    530                 535                 540                 


His Lys Val Ala His Phe Lys Asp Tyr Ile Pro Gln Ala Phe Pro Gly 
545                 550                 555                 560 


Gly His Ser Met Ile Leu Asp Ser Glu Val Leu Leu Ile Asp Asn Lys 
                565                 570                 575     


Thr Gly Lys Pro Leu Pro Phe Gly Thr Leu Gly Val His Lys Lys Ala 
            580                 585                 590         


Ala Phe Gln Asp Ala Asn Val Cys Leu Phe Val Phe Asp Cys Ile Tyr 
        595                 600                 605             


Phe Asn Asp Val Ser Leu Met Asp Arg Pro Leu Cys Glu Arg Arg Lys 
    610                 615                 620                 


Phe Leu His Asp Asn Met Val Glu Ile Pro Asn Arg Ile Met Phe Ser 
625                 630                 635                 640 


Glu Met Lys Arg Val Thr Lys Ala Leu Asp Leu Ala Asp Met Ile Thr 
                645                 650                 655     


Arg Val Ile Gln Glu Gly Leu Glu Gly Leu Val Leu Lys Asp Val Lys 
            660                 665                 670         


Gly Thr Tyr Glu Pro Gly Lys Arg His Trp Leu Lys Val Lys Lys Asp 
        675                 680                 685             


Tyr Leu Asn Glu Gly Ala Met Ala Asp Thr Ala Asp Leu Val Val Leu 
    690                 695                 700                 


Gly Ala Phe Tyr Gly Gln Gly Ser Lys Gly Gly Met Met Ser Ile Phe 
705                 710                 715                 720 


Leu Met Gly Cys Tyr Asp Pro Gly Ser Gln Lys Trp Cys Thr Val Thr 
                725                 730                 735     


Lys Cys Ala Gly Gly His Asp Asp Ala Thr Leu Ala Arg Leu Gln Asn 
            740                 745                 750         


Glu Leu Asp Met Val Lys Ile Ser Lys Asp Pro Ser Lys Ile Pro Ser 
        755                 760                 765             


Trp Leu Lys Val Asn Lys Ile Tyr Tyr Pro Asp Phe Ile Val Pro Asp 
    770                 775                 780                 


Pro Lys Lys Ala Ala Val Trp Glu Ile Thr Gly Ala Glu Phe Ser Lys 
785                 790                 795                 800 


Ser Glu Ala His Thr Ala Asp Gly Ile Ser Ile Arg Phe Pro Arg Cys 
                805                 810                 815     


Thr Arg Ile Arg Asp Asp Lys Asp Trp Lys Ser Ala Thr Asn Leu Pro 
            820                 825                 830         


Gln Leu Lys Glu Leu Tyr Gln Leu Ser Lys Glu Lys Ala Asp Phe Thr 
        835                 840                 845             


Val Val Ala Gly Asp Glu Gly Ser Ser Thr Thr Gly Gly Ser Ser Glu 
    850                 855                 860                 


Glu Asn Lys Gly Pro Ser Gly Ser Ala Val Ser Arg Lys Ala Pro Ser 
865                 870                 875                 880 


Lys Pro Ser Ala Ser Thr Lys Lys Ala Glu Gly Lys Leu Ser Asn Ser 
                885                 890                 895     


Asn Ser Lys Asp Gly Asn Met Gln Thr Ala Lys Pro Ser Ala Met Lys 
            900                 905                 910         


Val Gly Glu Lys Leu Ala Thr Lys Ser Ser Pro Val Lys Val Gly Glu 
        915                 920                 925             


Lys Arg Lys Ala Ala Asp Glu Thr Leu Cys Gln Thr Lys Val Leu Leu 
    930                 935                 940                 


Asp Ile Phe Thr Gly Val Arg Leu Tyr Leu Pro Pro Ser Thr Pro Asp 
945                 950                 955                 960 


Phe Ser Arg Leu Arg Arg Tyr Phe Val Ala Phe Asp Gly Asp Leu Val 
                965                 970                 975     


Gln Glu Phe Asp Met Thr Ser Ala Thr His Val Leu Gly Ser Arg Asp 
            980                 985                 990         


Lys Asn Pro Ala Ala Gln Gln Val  Ser Pro Glu Trp Ile  Trp Ala Cys 
        995                 1000                 1005             


Ile Arg  Lys Arg Arg Leu Val  Ala Pro Cys 
    1010                 1015             


<210>  56
<211>  1009
<212>  PRT
<213>  homo sapiens

<400>  56

Met Ser Leu Ala Phe Lys Ile Phe Phe Pro Gln Thr Leu Arg Ala Leu 
1               5                   10                  15      


Ser Arg Lys Glu Leu Cys Leu Phe Arg Lys His His Trp Arg Asp Val 
            20                  25                  30          


Arg Gln Phe Ser Gln Trp Ser Glu Thr Asp Leu Leu His Gly His Pro 
        35                  40                  45              


Leu Phe Leu Arg Arg Lys Pro Val Leu Ser Phe Gln Gly Ser His Leu 
    50                  55                  60                  


Arg Ser Arg Ala Thr Tyr Leu Val Phe Leu Pro Gly Leu His Val Gly 
65                  70                  75                  80  


Leu Cys Ser Gly Pro Cys Glu Met Ala Glu Gln Arg Phe Cys Val Asp 
                85                  90                  95      


Tyr Ala Lys Arg Gly Thr Ala Gly Cys Lys Lys Cys Lys Glu Lys Ile 
            100                 105                 110         


Val Lys Gly Val Cys Arg Ile Gly Lys Val Val Pro Asn Pro Phe Ser 
        115                 120                 125             


Glu Ser Gly Gly Asp Met Lys Glu Trp Tyr His Ile Lys Cys Met Phe 
    130                 135                 140                 


Glu Lys Leu Glu Arg Ala Arg Ala Thr Thr Lys Lys Ile Glu Asp Leu 
145                 150                 155                 160 


Thr Glu Leu Glu Gly Trp Glu Glu Leu Glu Asp Asn Glu Lys Glu Gln 
                165                 170                 175     


Ile Thr Gln His Ile Ala Asp Leu Ser Ser Lys Ala Ala Gly Thr Pro 
            180                 185                 190         


Lys Lys Lys Ala Val Val Gln Ala Lys Leu Thr Thr Thr Gly Gln Val 
        195                 200                 205             


Thr Ser Pro Val Lys Gly Ala Ser Phe Val Thr Ser Thr Asn Pro Arg 
    210                 215                 220                 


Lys Phe Ser Gly Phe Ser Ala Lys Pro Asn Asn Ser Gly Glu Ala Pro 
225                 230                 235                 240 


Ser Ser Pro Thr Pro Lys Arg Ser Leu Ser Ser Ser Lys Cys Asp Pro 
                245                 250                 255     


Arg His Lys Asp Cys Leu Leu Arg Glu Phe Arg Lys Leu Cys Ala Met 
            260                 265                 270         


Val Ala Asp Asn Pro Ser Tyr Asn Thr Lys Thr Gln Ile Ile Gln Asp 
        275                 280                 285             


Phe Leu Arg Lys Gly Ser Ala Gly Asp Gly Phe His Gly Asp Val Tyr 
    290                 295                 300                 


Leu Thr Val Lys Leu Leu Leu Pro Gly Val Ile Lys Thr Val Tyr Asn 
305                 310                 315                 320 


Leu Asn Asp Lys Gln Ile Val Lys Leu Phe Ser Arg Ile Phe Asn Cys 
                325                 330                 335     


Asn Pro Asp Asp Met Ala Arg Asp Leu Glu Gln Gly Asp Val Ser Glu 
            340                 345                 350         


Thr Ile Arg Val Phe Phe Glu Gln Ser Lys Ser Phe Pro Pro Ala Ala 
        355                 360                 365             


Lys Ser Leu Leu Thr Ile Gln Glu Val Asp Glu Phe Leu Leu Arg Leu 
    370                 375                 380                 


Ser Lys Leu Thr Lys Glu Asp Glu Gln Gln Gln Ala Leu Gln Asp Ile 
385                 390                 395                 400 


Ala Ser Arg Cys Thr Ala Asn Asp Leu Lys Cys Ile Ile Arg Leu Ile 
                405                 410                 415     


Lys His Asp Leu Lys Met Asn Ser Gly Ala Lys His Val Leu Asp Ala 
            420                 425                 430         


Leu Asp Pro Asn Ala Tyr Glu Ala Phe Lys Ala Ser Arg Asn Leu Gln 
        435                 440                 445             


Asp Val Val Glu Arg Val Leu His Asn Ala Gln Glu Val Glu Lys Glu 
    450                 455                 460                 


Pro Gly Gln Arg Arg Ala Leu Ser Val Gln Ala Ser Leu Met Thr Pro 
465                 470                 475                 480 


Val Gln Pro Met Leu Ala Glu Ala Cys Lys Ser Val Glu Tyr Ala Met 
                485                 490                 495     


Lys Lys Cys Pro Asn Gly Met Phe Ser Glu Ile Lys Tyr Asp Gly Glu 
            500                 505                 510         


Arg Val Gln Val His Lys Asn Gly Asp His Phe Ser Tyr Phe Ser Arg 
        515                 520                 525             


Ser Leu Lys Pro Val Leu Pro His Lys Val Ala His Phe Lys Asp Tyr 
    530                 535                 540                 


Ile Pro Gln Ala Phe Pro Gly Gly His Ser Met Ile Leu Asp Ser Glu 
545                 550                 555                 560 


Val Leu Leu Ile Asp Asn Lys Thr Gly Lys Pro Leu Pro Phe Gly Thr 
                565                 570                 575     


Leu Gly Val His Lys Lys Ala Ala Phe Gln Asp Ala Asn Val Cys Leu 
            580                 585                 590         


Phe Val Phe Asp Cys Ile Tyr Phe Asn Asp Val Ser Leu Met Asp Arg 
        595                 600                 605             


Pro Leu Cys Glu Arg Arg Lys Phe Leu His Asp Asn Met Val Glu Ile 
    610                 615                 620                 


Pro Asn Arg Ile Met Phe Ser Glu Met Lys Arg Val Thr Lys Ala Leu 
625                 630                 635                 640 


Asp Leu Ala Asp Met Ile Thr Arg Val Ile Gln Glu Gly Leu Glu Gly 
                645                 650                 655     


Leu Val Leu Lys Asp Val Lys Gly Thr Tyr Glu Pro Gly Lys Arg His 
            660                 665                 670         


Trp Leu Lys Val Lys Lys Asp Tyr Leu Asn Glu Gly Ala Met Ala Asp 
        675                 680                 685             


Thr Ala Asp Leu Val Val Leu Gly Ala Phe Tyr Gly Gln Gly Ser Lys 
    690                 695                 700                 


Gly Gly Met Met Ser Ile Phe Leu Met Gly Cys Tyr Asp Pro Gly Ser 
705                 710                 715                 720 


Gln Lys Trp Cys Thr Val Thr Lys Cys Ala Gly Gly His Asp Asp Ala 
                725                 730                 735     


Thr Leu Ala Arg Leu Gln Asn Glu Leu Asp Met Val Lys Ile Ser Lys 
            740                 745                 750         


Asp Pro Ser Lys Ile Pro Ser Trp Leu Lys Val Asn Lys Ile Tyr Tyr 
        755                 760                 765             


Pro Asp Phe Ile Val Pro Asp Pro Lys Lys Ala Ala Val Trp Glu Ile 
    770                 775                 780                 


Thr Gly Ala Glu Phe Ser Lys Ser Glu Ala His Thr Ala Asp Gly Ile 
785                 790                 795                 800 


Ser Ile Arg Phe Pro Arg Cys Thr Arg Ile Arg Asp Asp Lys Asp Trp 
                805                 810                 815     


Lys Ser Ala Thr Asn Leu Pro Gln Leu Lys Glu Leu Tyr Gln Leu Ser 
            820                 825                 830         


Lys Glu Lys Ala Asp Phe Thr Val Val Ala Gly Asp Glu Gly Ser Ser 
        835                 840                 845             


Thr Thr Gly Gly Ser Ser Glu Glu Asn Lys Gly Pro Ser Gly Ser Ala 
    850                 855                 860                 


Val Ser Arg Lys Ala Pro Ser Lys Pro Ser Ala Ser Thr Lys Lys Ala 
865                 870                 875                 880 


Glu Gly Lys Leu Ser Asn Ser Asn Ser Lys Asp Gly Asn Met Gln Thr 
                885                 890                 895     


Ala Lys Pro Ser Ala Met Lys Val Gly Glu Lys Leu Ala Thr Lys Ser 
            900                 905                 910         


Ser Pro Val Lys Val Gly Glu Lys Arg Lys Ala Ala Asp Glu Thr Leu 
        915                 920                 925             


Cys Gln Thr Lys Val Leu Leu Asp Ile Phe Thr Gly Val Arg Leu Tyr 
    930                 935                 940                 


Leu Pro Pro Ser Thr Pro Asp Phe Ser Arg Leu Arg Arg Tyr Phe Val 
945                 950                 955                 960 


Ala Phe Asp Gly Asp Leu Val Gln Glu Phe Asp Met Thr Ser Ala Thr 
                965                 970                 975     


His Val Leu Gly Ser Arg Asp Lys Asn Pro Ala Ala Gln Gln Val Ser 
            980                 985                 990         


Pro Glu Trp Ile Trp Ala Cys Ile  Arg Lys Arg Arg Leu  Val Ala Pro 
        995                 1000                 1005             


Cys 
    


<210>  57
<211>  958
<212>  PRT
<213>  homo sapiens

<400>  57

Met Ser Lys Phe Arg Gly Leu Arg Tyr Met Ser Leu Ala Phe Lys Ile 
1               5                   10                  15      


Phe Phe Pro Gln Thr Leu Arg Ala Leu Ser Arg Lys Glu Leu Cys Leu 
            20                  25                  30          


Phe Arg Lys His His Trp Arg Asp Val Arg Gln Phe Ser Gln Trp Ser 
        35                  40                  45              


Glu Thr Asp Leu Leu His Gly His Pro Leu Phe Leu Arg Arg Lys Pro 
    50                  55                  60                  


Val Leu Ser Phe Gln Gly Ser His Leu Arg Ser Arg Ala Thr Tyr Leu 
65                  70                  75                  80  


Val Phe Leu Pro Gly Leu His Val Gly Leu Cys Ser Gly Pro Cys Glu 
                85                  90                  95      


Met Ala Glu Gln Arg Phe Cys Val Asp Tyr Ala Lys Arg Gly Thr Ala 
            100                 105                 110         


Gly Cys Lys Lys Cys Lys Glu Lys Ile Val Lys Gly Val Cys Arg Ile 
        115                 120                 125             


Gly Lys Val Val Pro Asn Pro Phe Ser Glu Ser Gly Gly Asp Met Lys 
    130                 135                 140                 


Glu Trp Tyr His Ile Lys Cys Met Phe Glu Lys Leu Glu Arg Ala Arg 
145                 150                 155                 160 


Ala Thr Thr Lys Lys Ile Glu Asp Leu Thr Glu Leu Glu Gly Trp Glu 
                165                 170                 175     


Glu Leu Glu Asp Asn Glu Lys Glu Gln Ile Thr Gln His Ile Ala Asp 
            180                 185                 190         


Leu Ser Ser Lys Ala Ala Gly Thr Pro Lys Lys Lys Ala Val Val Gln 
        195                 200                 205             


Ala Lys Leu Thr Thr Thr Gly Gln Val Thr Ser Pro Val Lys Gly Ala 
    210                 215                 220                 


Ser Phe Val Thr Ser Thr Asn Pro Arg Lys Phe Ser Gly Phe Ser Ala 
225                 230                 235                 240 


Lys Pro Asn Asn Ser Gly Glu Ala Pro Ser Ser Pro Thr Pro Lys Arg 
                245                 250                 255     


Ser Leu Ser Ser Ser Lys Cys Asp Pro Arg His Lys Asp Cys Leu Leu 
            260                 265                 270         


Arg Glu Phe Arg Lys Leu Cys Ala Met Val Ala Asp Asn Pro Ser Tyr 
        275                 280                 285             


Asn Thr Lys Thr Gln Ile Ile Gln Asp Phe Leu Arg Lys Gly Ser Ala 
    290                 295                 300                 


Gly Asp Gly Phe His Gly Asp Val Tyr Leu Thr Val Lys Leu Leu Leu 
305                 310                 315                 320 


Pro Gly Val Ile Lys Thr Val Tyr Asn Leu Asn Asp Lys Gln Ile Val 
                325                 330                 335     


Lys Leu Phe Ser Arg Ile Phe Asn Cys Asn Pro Asp Asp Met Ala Arg 
            340                 345                 350         


Asp Leu Glu Gln Gly Asp Val Ser Glu Thr Ile Arg Val Phe Phe Glu 
        355                 360                 365             


Gln Ser Lys Ser Phe Pro Pro Ala Ala Lys Ser Leu Leu Thr Ile Gln 
    370                 375                 380                 


Glu Val Asp Glu Phe Leu Leu Arg Leu Ser Lys Leu Thr Lys Glu Asp 
385                 390                 395                 400 


Glu Gln Gln Gln Ala Leu Gln Asp Ile Ala Ser Arg Cys Thr Ala Asn 
                405                 410                 415     


Asp Leu Lys Cys Ile Ile Arg Leu Ile Lys His Asp Leu Lys Met Asn 
            420                 425                 430         


Ser Gly Ala Lys His Val Leu Asp Ala Leu Asp Pro Asn Ala Tyr Glu 
        435                 440                 445             


Ala Phe Lys Ala Ser Arg Asn Leu Gln Asp Val Val Glu Arg Val Leu 
    450                 455                 460                 


His Asn Ala Gln Glu Val Glu Lys Glu Pro Gly Gln Arg Arg Ala Leu 
465                 470                 475                 480 


Ser Val Gln Ala Ser Leu Met Thr Pro Val Gln Pro Met Leu Ala Glu 
                485                 490                 495     


Ala Cys Lys Ser Val Glu Tyr Ala Met Lys Lys Cys Pro Asn Gly Met 
            500                 505                 510         


Phe Ser Glu Ile Lys Tyr Asp Gly Glu Arg Val Gln Val His Lys Asn 
        515                 520                 525             


Gly Asp His Phe Ser Tyr Phe Ser Arg Ser Leu Lys Pro Val Leu Pro 
    530                 535                 540                 


His Lys Val Ala His Phe Lys Asp Tyr Ile Pro Gln Ala Phe Pro Gly 
545                 550                 555                 560 


Gly His Ser Met Ile Leu Asp Ser Glu Val Leu Leu Ile Asp Asn Lys 
                565                 570                 575     


Thr Gly Lys Pro Leu Pro Phe Gly Thr Leu Gly Val His Lys Lys Ala 
            580                 585                 590         


Ala Phe Gln Asp Ala Asn Val Cys Leu Phe Val Phe Asp Cys Ile Tyr 
        595                 600                 605             


Phe Asn Asp Val Ser Leu Met Asp Arg Pro Leu Cys Glu Arg Arg Lys 
    610                 615                 620                 


Phe Leu His Asp Asn Met Val Glu Ile Pro Asn Arg Ile Met Phe Ser 
625                 630                 635                 640 


Glu Met Lys Arg Val Thr Lys Ala Leu Asp Leu Ala Asp Met Ile Thr 
                645                 650                 655     


Arg Val Ile Gln Glu Gly Leu Glu Gly Leu Val Leu Lys Asp Val Lys 
            660                 665                 670         


Gly Thr Tyr Glu Pro Gly Lys Arg His Trp Leu Lys Val Lys Lys Asp 
        675                 680                 685             


Tyr Leu Asn Glu Gly Ala Met Ala Asp Thr Ala Asp Leu Val Val Leu 
    690                 695                 700                 


Gly Ala Phe Tyr Gly Gln Gly Ser Lys Gly Gly Met Met Ser Ile Phe 
705                 710                 715                 720 


Leu Met Gly Cys Tyr Asp Pro Gly Ser Gln Lys Trp Cys Thr Val Thr 
                725                 730                 735     


Lys Cys Ala Gly Gly His Asp Asp Ala Thr Leu Ala Arg Leu Gln Asn 
            740                 745                 750         


Glu Leu Asp Met Val Lys Ile Ser Lys Asp Pro Ser Lys Ile Pro Ser 
        755                 760                 765             


Trp Leu Lys Val Asn Lys Ile Tyr Tyr Pro Asp Phe Ile Val Pro Asp 
    770                 775                 780                 


Pro Lys Lys Ala Ala Val Trp Glu Ile Thr Gly Ala Glu Phe Ser Lys 
785                 790                 795                 800 


Ser Glu Ala His Thr Ala Asp Gly Ile Ser Ile Arg Phe Pro Arg Cys 
                805                 810                 815     


Thr Arg Ile Arg Asp Asp Lys Asp Trp Lys Ser Ala Thr Asn Leu Pro 
            820                 825                 830         


Gln Leu Lys Glu Leu Tyr Gln Leu Ser Lys Glu Lys Ala Asp Phe Thr 
        835                 840                 845             


Val Val Ala Gly Asp Glu Gly Ser Ser Thr Thr Gly Gly Ser Ser Glu 
    850                 855                 860                 


Glu Asn Lys Gly Pro Ser Gly Ser Ala Val Ser Arg Lys Ala Pro Ser 
865                 870                 875                 880 


Lys Pro Ser Ala Ser Thr Lys Lys Ala Glu Gly Lys Leu Ser Asn Ser 
                885                 890                 895     


Asn Ser Lys Asp Gly Asn Met Gln Thr Ala Lys Pro Ser Ala Met Lys 
            900                 905                 910         


Val Gly Glu Lys Leu Ala Thr Lys Ser Ser Pro Val Lys Val Gly Glu 
        915                 920                 925             


Lys Arg Lys Ala Ala Asp Glu Thr Leu Cys Gln Thr Lys Arg Arg Pro 
    930                 935                 940                 


Ala Ser Glu Gln Arg Gly Arg Thr Val Pro Ala Gly Arg Arg 
945                 950                 955             


<210>  58
<211>  633
<212>  PRT
<213>  homo sapiens

<400>  58

Met Pro Glu Ile Arg Leu Arg His Val Val Ser Cys Ser Ser Gln Asp 
1               5                   10                  15      


Ser Thr His Cys Ala Glu Asn Leu Leu Lys Ala Asp Thr Tyr Arg Lys 
            20                  25                  30          


Trp Arg Ala Ala Lys Ala Gly Glu Lys Thr Ile Ser Val Val Leu Gln 
        35                  40                  45              


Leu Glu Lys Glu Glu Gln Ile His Ser Val Asp Ile Gly Asn Asp Gly 
    50                  55                  60                  


Ser Ala Phe Val Glu Val Leu Val Gly Ser Ser Ala Gly Gly Ala Gly 
65                  70                  75                  80  


Glu Gln Asp Tyr Glu Val Leu Leu Val Thr Ser Ser Phe Met Ser Pro 
                85                  90                  95      


Ser Glu Ser Arg Ser Gly Ser Asn Pro Asn Arg Val Arg Met Phe Gly 
            100                 105                 110         


Pro Asp Lys Leu Val Arg Ala Ala Ala Glu Lys Arg Trp Asp Arg Val 
        115                 120                 125             


Lys Ile Val Cys Ser Gln Pro Tyr Ser Lys Asp Ser Pro Phe Gly Leu 
    130                 135                 140                 


Ser Phe Val Arg Phe His Ser Pro Pro Asp Lys Asp Glu Ala Glu Ala 
145                 150                 155                 160 


Pro Ser Gln Lys Val Thr Val Thr Lys Leu Gly Gln Phe Arg Val Lys 
                165                 170                 175     


Glu Glu Asp Glu Ser Ala Asn Ser Leu Arg Pro Gly Ala Leu Phe Phe 
            180                 185                 190         


Ser Arg Ile Asn Lys Thr Ser Pro Val Thr Ala Ser Asp Pro Ala Gly 
        195                 200                 205             


Pro Ser Tyr Ala Ala Ala Thr Leu Gln Ala Ser Ser Ala Ala Ser Ser 
    210                 215                 220                 


Ala Ser Pro Val Ser Arg Ala Ile Gly Ser Thr Ser Lys Pro Gln Glu 
225                 230                 235                 240 


Ser Pro Lys Gly Lys Arg Lys Leu Asp Leu Asn Gln Glu Glu Lys Lys 
                245                 250                 255     


Thr Pro Ser Lys Pro Pro Ala Gln Leu Ser Pro Ser Val Pro Lys Arg 
            260                 265                 270         


Pro Lys Leu Pro Ala Pro Thr Arg Thr Pro Ala Thr Ala Pro Val Pro 
        275                 280                 285             


Ala Arg Ala Gln Gly Ala Val Thr Gly Lys Pro Arg Gly Glu Gly Thr 
    290                 295                 300                 


Glu Pro Arg Arg Pro Arg Ala Gly Pro Glu Glu Leu Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gly Val Val Val Val Leu Ser Gly Phe Gln Asn Pro Phe Arg Ser 
                325                 330                 335     


Glu Leu Arg Asp Lys Ala Leu Glu Leu Gly Ala Lys Tyr Arg Pro Asp 
            340                 345                 350         


Trp Thr Arg Asp Ser Thr His Leu Ile Cys Ala Phe Ala Asn Thr Pro 
        355                 360                 365             


Lys Tyr Ser Gln Val Leu Gly Leu Gly Gly Arg Ile Val Arg Lys Glu 
    370                 375                 380                 


Trp Val Leu Asp Cys His Arg Met Arg Arg Arg Leu Pro Ser Gln Arg 
385                 390                 395                 400 


Tyr Leu Met Ala Gly Pro Gly Ser Ser Ser Glu Glu Asp Glu Ala Ser 
                405                 410                 415     


His Ser Gly Gly Ser Gly Asp Glu Ala Pro Lys Leu Pro Gln Lys Gln 
            420                 425                 430         


Pro Gln Thr Lys Thr Lys Pro Thr Gln Ala Ala Gly Pro Ser Ser Pro 
        435                 440                 445             


Gln Lys Pro Pro Thr Pro Glu Glu Thr Lys Ala Ala Ser Pro Val Leu 
    450                 455                 460                 


Gln Glu Asp Ile Asp Ile Glu Gly Val Gln Ser Glu Gly Gln Asp Asn 
465                 470                 475                 480 


Gly Ala Glu Asp Ser Gly Asp Thr Glu Asp Glu Leu Arg Arg Val Ala 
                485                 490                 495     


Glu Gln Lys Glu His Arg Leu Pro Pro Gly Gln Glu Glu Asn Gly Glu 
            500                 505                 510         


Asp Pro Tyr Ala Gly Ser Thr Asp Glu Asn Thr Asp Ser Glu Glu His 
        515                 520                 525             


Gln Glu Pro Pro Asp Leu Pro Val Pro Glu Leu Pro Asp Phe Phe Gln 
    530                 535                 540                 


Gly Lys His Phe Phe Leu Tyr Gly Glu Phe Pro Gly Asp Glu Arg Arg 
545                 550                 555                 560 


Lys Leu Ile Arg Tyr Val Thr Ala Phe Asn Gly Glu Leu Glu Asp Tyr 
                565                 570                 575     


Met Ser Asp Arg Val Gln Phe Val Ile Thr Ala Gln Glu Trp Asp Pro 
            580                 585                 590         


Ser Phe Glu Glu Ala Leu Met Asp Asn Pro Ser Leu Ala Phe Val Arg 
        595                 600                 605             


Pro Arg Trp Ile Tyr Ser Cys Asn Glu Lys Gln Lys Leu Leu Pro His 
    610                 615                 620                 


Gln Leu Tyr Gly Val Val Pro Gln Ala 
625                 630             


<210>  59
<211>  3056
<212>  PRT
<213>  homo sapiens

<400>  59

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Thr Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Thr Phe  Lys Asn Thr 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Thr Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Thr Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp Lys Thr  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Thr Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Thr Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr Glu Thr  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Thr 
    2840                 2845                 2850             


Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Gly Val Ala Phe Glu  Gln Gly Lys 
    2885                 2890                 2895             


Ile Leu  Pro Thr Pro Glu Thr  Val Pro Phe Arg Leu  Thr Arg Asp 
    2900                 2905                 2910             


Ile Val  Asp Gly Met Gly Ile  Thr Gly Val Glu Gly  Val Phe Arg 
    2915                 2920                 2925             


Arg Cys  Cys Glu Lys Thr Met  Glu Val Met Arg Asn  Ser Gln Glu 
    2930                 2935                 2940             


Thr Leu  Leu Thr Ile Val Glu  Val Leu Leu Tyr Asp  Pro Leu Phe 
    2945                 2950                 2955             


Asp Trp  Thr Met Asn Pro Leu  Lys Ala Leu Tyr Leu  Gln Gln Arg 
    2960                 2965                 2970             


Pro Glu  Asp Glu Thr Glu Leu  His Pro Thr Leu Asn  Ala Asp Asp 
    2975                 2980                 2985             


Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile Asp Gln  Ser Phe Asn 
    2990                 2995                 3000             


Lys Val  Ala Glu Arg Val Leu  Met Arg Leu Gln Glu  Lys Leu Lys 
    3005                 3010                 3015             


Gly Val  Glu Glu Gly Thr Val  Leu Ser Val Gly Gly  Gln Val Asn 
    3020                 3025                 3030             


Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys Asn Leu  Ser Arg Leu 
    3035                 3040                 3045             


Phe Pro  Gly Trp Lys Ala Trp  Val 
    3050                 3055     


<210>  60
<211>  112
<212>  PRT
<213>  homo sapiens

<400>  60

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Ser Lys 
            100                 105                 110         


<210>  61
<211>  3056
<212>  PRT
<213>  homo sapiens

<400>  61

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Thr Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Thr Phe  Lys Asn Thr 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Thr Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Thr Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp Lys Thr  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Thr Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Thr Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr Glu Thr  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Thr 
    2840                 2845                 2850             


Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Gly Val Ala Phe Glu  Gln Gly Lys 
    2885                 2890                 2895             


Ile Leu  Pro Thr Pro Glu Thr  Val Pro Phe Arg Leu  Thr Arg Asp 
    2900                 2905                 2910             


Ile Val  Asp Gly Met Gly Ile  Thr Gly Val Glu Gly  Val Phe Arg 
    2915                 2920                 2925             


Arg Cys  Cys Glu Lys Thr Met  Glu Val Met Arg Asn  Ser Gln Glu 
    2930                 2935                 2940             


Thr Leu  Leu Thr Ile Val Glu  Val Leu Leu Tyr Asp  Pro Leu Phe 
    2945                 2950                 2955             


Asp Trp  Thr Met Asn Pro Leu  Lys Ala Leu Tyr Leu  Gln Gln Arg 
    2960                 2965                 2970             


Pro Glu  Asp Glu Thr Glu Leu  His Pro Thr Leu Asn  Ala Asp Asp 
    2975                 2980                 2985             


Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile Asp Gln  Ser Phe Asn 
    2990                 2995                 3000             


Lys Val  Ala Glu Arg Val Leu  Met Arg Leu Gln Glu  Lys Leu Lys 
    3005                 3010                 3015             


Gly Val  Glu Glu Gly Thr Val  Leu Ser Val Gly Gly  Gln Val Asn 
    3020                 3025                 3030             


Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys Asn Leu  Ser Arg Leu 
    3035                 3040                 3045             


Phe Pro  Gly Trp Lys Ala Trp  Val 
    3050                 3055     


<210>  62
<211>  3001
<212>  PRT
<213>  homo sapiens

<400>  62

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Lys Leu 
            100                 105                 110         


Phe Ser Val Tyr Phe Arg Leu Tyr Leu Lys Pro Ser Gln Asp Val His 
        115                 120                 125             


Arg Val Leu Val Ala Arg Ile Ile His Ala Val Thr Lys Gly Cys Cys 
    130                 135                 140                 


Ser Gln Thr Asp Gly Leu Asn Ser Lys Phe Leu Asp Phe Phe Ser Lys 
145                 150                 155                 160 


Ala Ile Gln Cys Ala Arg Gln Glu Lys Ser Ser Ser Gly Leu Asn His 
                165                 170                 175     


Ile Leu Ala Ala Leu Thr Ile Phe Leu Lys Thr Leu Ala Val Asn Phe 
            180                 185                 190         


Arg Ile Arg Val Cys Glu Leu Gly Asp Glu Ile Leu Pro Thr Leu Leu 
        195                 200                 205             


Tyr Ile Trp Thr Gln His Arg Leu Asn Asp Ser Leu Lys Glu Val Ile 
    210                 215                 220                 


Ile Glu Leu Phe Gln Leu Gln Ile Tyr Ile His His Pro Lys Gly Ala 
225                 230                 235                 240 


Lys Thr Gln Glu Lys Gly Ala Tyr Glu Ser Thr Lys Trp Arg Ser Ile 
                245                 250                 255     


Leu Tyr Asn Leu Tyr Asp Leu Leu Val Asn Glu Ile Ser His Ile Gly 
            260                 265                 270         


Ser Arg Gly Lys Tyr Ser Ser Gly Phe Arg Asn Ile Ala Val Lys Glu 
        275                 280                 285             


Asn Leu Ile Glu Leu Met Ala Asp Ile Cys His Gln Val Phe Asn Glu 
    290                 295                 300                 


Asp Thr Arg Ser Leu Glu Ile Ser Gln Ser Tyr Thr Thr Thr Gln Arg 
305                 310                 315                 320 


Glu Ser Ser Asp Tyr Ser Val Pro Cys Lys Arg Lys Lys Ile Glu Leu 
                325                 330                 335     


Gly Trp Glu Val Ile Lys Asp His Leu Gln Lys Ser Gln Asn Asp Phe 
            340                 345                 350         


Asp Leu Val Pro Trp Leu Gln Ile Ala Thr Gln Leu Ile Ser Lys Tyr 
        355                 360                 365             


Pro Ala Ser Leu Pro Asn Cys Glu Leu Ser Pro Leu Leu Met Ile Leu 
    370                 375                 380                 


Ser Gln Leu Leu Pro Gln Gln Arg His Gly Glu Arg Thr Pro Tyr Val 
385                 390                 395                 400 


Leu Arg Cys Leu Thr Glu Val Ala Leu Cys Gln Asp Lys Arg Ser Asn 
                405                 410                 415     


Leu Glu Ser Ser Gln Lys Ser Asp Leu Leu Lys Leu Trp Asn Lys Ile 
            420                 425                 430         


Trp Cys Ile Thr Phe Arg Gly Ile Ser Ser Glu Gln Ile Gln Ala Glu 
        435                 440                 445             


Asn Phe Gly Leu Leu Gly Ala Ile Ile Gln Gly Ser Leu Val Glu Val 
    450                 455                 460                 


Asp Arg Glu Phe Trp Lys Leu Phe Thr Gly Ser Ala Cys Arg Pro Ser 
465                 470                 475                 480 


Cys Pro Ala Val Cys Cys Leu Thr Leu Ala Leu Thr Thr Ser Ile Val 
                485                 490                 495     


Pro Gly Thr Val Lys Met Gly Ile Glu Gln Asn Met Cys Glu Val Asn 
            500                 505                 510         


Arg Ser Phe Ser Leu Lys Glu Ser Ile Met Lys Trp Leu Leu Phe Tyr 
        515                 520                 525             


Gln Leu Glu Gly Asp Leu Glu Asn Ser Thr Glu Val Pro Pro Ile Leu 
    530                 535                 540                 


His Ser Asn Phe Pro His Leu Val Leu Glu Lys Ile Leu Val Ser Leu 
545                 550                 555                 560 


Thr Met Lys Asn Cys Lys Ala Ala Met Asn Phe Phe Gln Ser Val Pro 
                565                 570                 575     


Glu Cys Glu His His Gln Lys Asp Lys Glu Glu Leu Ser Phe Ser Glu 
            580                 585                 590         


Val Glu Glu Leu Phe Leu Gln Thr Thr Phe Asp Lys Met Asp Phe Leu 
        595                 600                 605             


Thr Ile Val Arg Glu Cys Gly Ile Glu Lys His Gln Ser Ser Ile Gly 
    610                 615                 620                 


Phe Ser Val His Gln Asn Leu Lys Glu Ser Leu Asp Arg Cys Leu Leu 
625                 630                 635                 640 


Gly Leu Ser Glu Gln Leu Leu Asn Asn Tyr Ser Ser Glu Ile Thr Asn 
                645                 650                 655     


Ser Glu Thr Leu Val Arg Cys Ser Arg Leu Leu Val Gly Val Leu Gly 
            660                 665                 670         


Cys Tyr Cys Tyr Met Gly Val Ile Ala Glu Glu Glu Ala Tyr Lys Ser 
        675                 680                 685             


Glu Leu Phe Gln Lys Ala Lys Ser Leu Met Gln Cys Ala Gly Glu Ser 
    690                 695                 700                 


Ile Thr Leu Phe Lys Asn Lys Thr Asn Glu Glu Phe Arg Ile Gly Ser 
705                 710                 715                 720 


Leu Arg Asn Met Met Gln Leu Cys Thr Arg Cys Leu Ser Asn Cys Thr 
                725                 730                 735     


Lys Lys Ser Pro Asn Lys Ile Ala Ser Gly Phe Phe Leu Arg Leu Leu 
            740                 745                 750         


Thr Ser Lys Leu Met Asn Asp Ile Ala Asp Ile Cys Lys Ser Leu Ala 
        755                 760                 765             


Ser Phe Ile Lys Lys Pro Phe Asp Arg Gly Glu Val Glu Ser Met Glu 
    770                 775                 780                 


Asp Asp Thr Asn Gly Asn Leu Met Glu Val Glu Asp Gln Ser Ser Met 
785                 790                 795                 800 


Asn Leu Phe Asn Asp Tyr Pro Asp Ser Ser Val Ser Asp Ala Asn Glu 
                805                 810                 815     


Pro Gly Glu Ser Gln Ser Thr Ile Gly Ala Ile Asn Pro Leu Ala Glu 
            820                 825                 830         


Glu Tyr Leu Ser Lys Gln Asp Leu Leu Phe Leu Asp Met Leu Lys Phe 
        835                 840                 845             


Leu Cys Leu Cys Val Thr Thr Ala Gln Thr Asn Thr Val Ser Phe Arg 
    850                 855                 860                 


Ala Ala Asp Ile Arg Arg Lys Leu Leu Met Leu Ile Asp Ser Ser Thr 
865                 870                 875                 880 


Leu Glu Pro Thr Lys Ser Leu His Leu His Met Tyr Leu Met Leu Leu 
                885                 890                 895     


Lys Glu Leu Pro Gly Glu Glu Tyr Pro Leu Pro Met Glu Asp Val Leu 
            900                 905                 910         


Glu Leu Leu Lys Pro Leu Ser Asn Val Cys Ser Leu Tyr Arg Arg Asp 
        915                 920                 925             


Gln Asp Val Cys Lys Thr Ile Leu Asn His Val Leu His Val Val Lys 
    930                 935                 940                 


Asn Leu Gly Gln Ser Asn Met Asp Ser Glu Asn Thr Arg Asp Ala Gln 
945                 950                 955                 960 


Gly Gln Phe Leu Thr Val Ile Gly Ala Phe Trp His Leu Thr Lys Glu 
                965                 970                 975     


Arg Lys Tyr Ile Phe Ser Val Arg Met Ala Leu Val Asn Cys Leu Lys 
            980                 985                 990         


Thr Leu Leu Glu Ala Asp Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val 
        995                 1000                 1005             


Met Gly  Lys Asp Phe Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu 
    1010                 1015                 1020             


Ala Asp  Asn His His Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile 
    1025                 1030                 1035             


Asn Arg  Leu Phe Gln Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu 
    1040                 1045                 1050             


Lys Ala  Leu Pro Leu Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala 
    1055                 1060                 1065             


Tyr Leu  Lys Ala Gln Glu Gly  Met Arg Glu Met Ser  His Ser Ala 
    1070                 1075                 1080             


Glu Asn  Pro Glu Thr Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val 
    1085                 1090                 1095             


Leu Leu  Thr Leu Ile Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys 
    1100                 1105                 1110             


Glu Lys  Gln Ala Leu Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn 
    1115                 1120                 1125             


Gly Leu  Glu Pro His Leu Val  Lys Lys Val Leu Glu  Lys Val Ser 
    1130                 1135                 1140             


Glu Thr  Phe Gly Tyr Arg Arg  Leu Glu Asp Phe Met  Ala Ser His 
    1145                 1150                 1155             


Leu Asp  Tyr Leu Val Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu 
    1160                 1165                 1170             


Tyr Asn  Leu Ser Ser Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn 
    1175                 1180                 1185             


Ile Glu  Asp Phe Tyr Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His 
    1190                 1195                 1200             


Leu Val  Ile Arg Ser His Phe  Asp Glu Val Lys Ser  Ile Ala Asn 
    1205                 1210                 1215             


Gln Ile  Gln Glu Asp Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro 
    1220                 1225                 1230             


Lys Ile  Leu Val Asn Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr 
    1235                 1240                 1245             


Arg Asp  Ser Gly Met Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val 
    1250                 1255                 1260             


Tyr Asp  Met Leu Lys Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp 
    1265                 1270                 1275             


His Leu  Phe Ile Ser Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu 
    1280                 1285                 1290             


Met Thr  Leu His Glu Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr 
    1295                 1300                 1305             


Asp Leu  Cys Asp Phe Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro 
    1310                 1315                 1320             


Pro His  Phe Pro Ser His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile 
    1325                 1330                 1335             


Ser Asn  Cys His Lys Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu 
    1340                 1345                 1350             


Ser Lys  Ser Pro Asp Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys 
    1355                 1360                 1365             


Glu Gln  Ala Ala Glu Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile 
    1370                 1375                 1380             


Leu Lys  Ile Tyr His Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile 
    1385                 1390                 1395             


Lys Ser  Gly Leu Gly Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val 
    1400                 1405                 1410             


Ile Tyr  Thr Leu Ile His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile 
    1415                 1420                 1425             


Met Asp  Val Ser Leu Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu 
    1430                 1435                 1440             


Ser Gln  Val Cys Gln Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu 
    1445                 1450                 1455             


Glu Asn  His Leu His Val Ile  Val Gly Thr Leu Ile  Pro Leu Val 
    1460                 1465                 1470             


Tyr Glu  Gln Val Glu Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys 
    1475                 1480                 1485             


Tyr Leu  Val Ile Asp Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr 
    1490                 1495                 1500             


Ile Lys  Leu Leu Asp Pro Phe  Pro Asp His Val Val  Phe Lys Asp 
    1505                 1510                 1515             


Leu Arg  Ile Thr Gln Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe 
    1520                 1525                 1530             


Ser Leu  Leu Glu Glu Ile Asn  His Phe Leu Ser Val  Ser Val Tyr 
    1535                 1540                 1545             


Asp Ala  Leu Pro Leu Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg 
    1550                 1555                 1560             


Arg Gln  Leu Glu Leu His Lys  Asp Gln Met Val Asp  Ile Met Arg 
    1565                 1570                 1575             


Ala Ser  Gln Asp Asn Pro Gln  Asp Gly Ile Met Val  Lys Leu Val 
    1580                 1585                 1590             


Val Asn  Leu Leu Gln Leu Ser  Lys Met Ala Ile Asn  His Thr Gly 
    1595                 1600                 1605             


Glu Lys  Glu Val Leu Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val 
    1610                 1615                 1620             


Gly Pro  Ile Asp Phe Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp 
    1625                 1630                 1635             


Ala Ser  Tyr Thr Lys Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu 
    1640                 1645                 1650             


Gln Trp  Thr Phe Ile Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val 
    1655                 1660                 1665             


Glu Asp  Cys Val Lys Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys 
    1670                 1675                 1680             


Asn Ile  Leu Ala Thr Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr 
    1685                 1690                 1695             


Lys Met  Thr Thr Asp Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg 
    1700                 1705                 1710             


Thr Ser  Arg Lys Lys Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu 
    1715                 1720                 1725             


Asn Pro  Phe Glu Gly Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu 
    1730                 1735                 1740             


Ser Glu  Asn His Asp Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe 
    1745                 1750                 1755             


Leu Asp  Ser Gly Gly Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys 
    1760                 1765                 1770             


Pro Met  Cys Glu Val Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro 
    1775                 1780                 1785             


Tyr Leu  Ile His Asp Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp 
    1790                 1795                 1800             


Arg Asn  Leu Leu Ser Thr His  Val Gln Gly Phe Phe  Thr Ser Cys 
    1805                 1810                 1815             


Leu Arg  His Phe Ser Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn 
    1820                 1825                 1830             


Leu Asp  Ser Glu Ser Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys 
    1835                 1840                 1845             


Lys Ser  Gln Arg Thr Met Leu  Ala Val Val Asp Tyr  Met Arg Arg 
    1850                 1855                 1860             


Gln Lys  Arg Pro Ser Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp 
    1865                 1870                 1875             


Leu Asp  Leu Asn Tyr Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys 
    1880                 1885                 1890             


Ala Ala  His Phe Thr Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp 
    1895                 1900                 1905             


Lys Lys  Ser Met Asp Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu 
    1910                 1915                 1920             


Glu Gly  Ser Gln Ser Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser 
    1925                 1930                 1935             


Lys Glu  Glu Thr Gly Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile 
    1940                 1945                 1950             


Tyr Arg  Ser Ile Gly Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly 
    1955                 1960                 1965             


Gly Lys  Met Leu Gln Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His 
    1970                 1975                 1980             


Glu Ala  Met Trp Gly Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr 
    1985                 1990                 1995             


Ala Ile  Pro Ser Ser Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu 
    2000                 2005                 2010             


Gln Asn  Leu Gly Leu Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly 
    2015                 2020                 2025             


Leu Asp  Tyr Glu Asn Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu 
    2030                 2035                 2040             


His Tyr  Gln Ala Ala Trp Arg  Asn Met Gln Trp Asp  His Cys Thr 
    2045                 2050                 2055             


Ser Val  Ser Lys Glu Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu 
    2060                 2065                 2070             


Tyr Asn  Ala Leu Gln Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe 
    2075                 2080                 2085             


Tyr Glu  Ser Leu Lys Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met 
    2090                 2095                 2100             


Cys Lys  Arg Ser Leu Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu 
    2105                 2110                 2115             


Ser Arg  Leu Gln Ala Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu 
    2120                 2125                 2130             


Phe Ser  Arg Ser Val Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile 
    2135                 2140                 2145             


Lys Trp  Gln Lys His Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser 
    2150                 2155                 2160             


Phe Gln  Glu Pro Ile Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile 
    2165                 2170                 2175             


Leu Met  Glu Lys Glu Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys 
    2180                 2185                 2190             


Asp Ile  Leu Thr Lys His Leu  Val Glu Leu Ser Ile  Leu Ala Arg 
    2195                 2200                 2205             


Thr Phe  Lys Asn Thr Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile 
    2210                 2215                 2220             


Lys Gln  Tyr Asn Ser Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu 
    2225                 2230                 2235             


Glu Glu  Ala Gln Val Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala 
    2240                 2245                 2250             


Leu Ser  Ile Leu Lys Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys 
    2255                 2260                 2265             


Ala Ala  Asn Asn Pro Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu 
    2270                 2275                 2280             


Arg Val  Cys Gly Asn Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro 
    2285                 2290                 2295             


Ala Val  Ile Met Gln Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala 
    2300                 2305                 2310             


Gly Asn  Tyr Asp Gly Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys 
    2315                 2320                 2325             


Met Lys  Ala Phe Leu Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr 
    2330                 2335                 2340             


Gln Arg  Ile Glu Asn Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys 
    2345                 2350                 2355             


Gln Ala  Leu Leu Lys Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg 
    2360                 2365                 2370             


Glu His  Lys Ile Gln Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg 
    2375                 2380                 2385             


Glu Leu  Glu Leu Asp Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp 
    2390                 2395                 2400             


Arg Lys  Arg Phe Leu Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys 
    2405                 2410                 2415             


Leu Leu  Ser Gly Glu Glu His  Asp Met Trp Val Phe  Arg Leu Cys 
    2420                 2425                 2430             


Ser Leu  Trp Leu Glu Asn Ser  Gly Val Ser Glu Val  Asn Gly Met 
    2435                 2440                 2445             


Met Lys  Arg Asp Gly Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro 
    2450                 2455                 2460             


Leu Met  Tyr Gln Leu Ala Ala  Arg Met Gly Thr Lys  Met Met Gly 
    2465                 2470                 2475             


Gly Leu  Gly Phe His Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile 
    2480                 2485                 2490             


Ser Met  Asp His Pro His His  Thr Leu Phe Ile Ile  Leu Ala Leu 
    2495                 2500                 2505             


Ala Asn  Ala Asn Arg Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala 
    2510                 2515                 2520             


Arg Arg  Ser Arg Ile Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln 
    2525                 2530                 2535             


Leu Asp  Glu Asp Arg Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr 
    2540                 2545                 2550             


Ile Arg  Ser Arg Arg Pro Gln  Met Val Arg Ser Val  Glu Ala Leu 
    2555                 2560                 2565             


Cys Asp  Ala Tyr Ile Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp 
    2570                 2575                 2580             


Lys Thr  Gln Arg Lys Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile 
    2585                 2590                 2595             


Thr Lys  Leu Lys Asn Leu Glu  Asp Val Val Val Pro  Thr Met Glu 
    2600                 2605                 2610             


Ile Lys  Val Asp His Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile 
    2615                 2620                 2625             


Gln Ser  Phe Lys Ala Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu 
    2630                 2635                 2640             


Pro Lys  Ile Ile Asp Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg 
    2645                 2650                 2655             


Gln Leu  Val Lys Gly Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met 
    2660                 2665                 2670             


Gln Gln  Val Phe Gln Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr 
    2675                 2680                 2685             


Glu Thr  Arg Lys Arg Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val 
    2690                 2695                 2700             


Pro Leu  Ser Gln Arg Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr 
    2705                 2710                 2715             


Val Pro  Ile Gly Glu Phe Leu  Val Asn Asn Glu Asp  Gly Ala His 
    2720                 2725                 2730             


Lys Arg  Tyr Arg Pro Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys 
    2735                 2740                 2745             


Lys Met  Met Glu Val Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu 
    2750                 2755                 2760             


Val Phe  Met Asp Val Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr 
    2765                 2770                 2775             


Phe Cys  Met Glu Lys Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys 
    2780                 2785                 2790             


Arg Leu  Ala Tyr Thr Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly 
    2795                 2800                 2805             


Tyr Ile  Leu Gly Leu Gly Asp  Arg His Val Gln Asn  Ile Leu Ile 
    2810                 2815                 2820             


Asn Glu  Gln Ser Ala Glu Leu  Val His Ile Asp Leu  Gly Val Ala 
    2825                 2830                 2835             


Phe Glu  Gln Gly Lys Ile Leu  Pro Thr Pro Glu Thr  Val Pro Phe 
    2840                 2845                 2850             


Arg Leu  Thr Arg Asp Ile Val  Asp Gly Met Gly Ile  Thr Gly Val 
    2855                 2860                 2865             


Glu Gly  Val Phe Arg Arg Cys  Cys Glu Lys Thr Met  Glu Val Met 
    2870                 2875                 2880             


Arg Asn  Ser Gln Glu Thr Leu  Leu Thr Ile Val Glu  Val Leu Leu 
    2885                 2890                 2895             


Tyr Asp  Pro Leu Phe Asp Trp  Thr Met Asn Pro Leu  Lys Ala Leu 
    2900                 2905                 2910             


Tyr Leu  Gln Gln Arg Pro Glu  Asp Glu Thr Glu Leu  His Pro Thr 
    2915                 2920                 2925             


Leu Asn  Ala Asp Asp Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile 
    2930                 2935                 2940             


Asp Gln  Ser Phe Asn Lys Val  Ala Glu Arg Val Leu  Met Arg Leu 
    2945                 2950                 2955             


Gln Glu  Lys Leu Lys Gly Val  Glu Glu Gly Thr Val  Leu Ser Val 
    2960                 2965                 2970             


Gly Gly  Gln Val Asn Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys 
    2975                 2980                 2985             


Asn Leu  Ser Arg Leu Phe Pro  Gly Trp Lys Ala Trp  Val 
    2990                 2995                 3000     


<210>  63
<211>  2912
<212>  PRT
<213>  homo sapiens

<400>  63

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Thr Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Thr Phe  Lys Asn Thr 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Thr Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Thr Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp Lys Thr  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Thr Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Thr Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr Glu Thr  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Thr 
    2840                 2845                 2850             


Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Glu Cys Arg Lys Arg  Ser Val Asn 
    2885                 2890                 2895             


Val Met  Thr Glu Ile Gln Asn  Leu Gln Gln Ile Asp  Phe Ser 
    2900                 2905                 2910         


<210>  64
<211>  2708
<212>  PRT
<213>  homo sapiens

<400>  64

Met Ala Asp Ile Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu 
1               5                   10                  15      


Glu Ile Ser Gln Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr 
            20                  25                  30          


Ser Val Pro Cys Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile 
        35                  40                  45              


Lys Asp His Leu Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp 
    50                  55                  60                  


Leu Gln Ile Ala Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro 
65                  70                  75                  80  


Asn Cys Glu Leu Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro 
                85                  90                  95      


Gln Gln Arg His Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr 
            100                 105                 110         


Glu Val Ala Leu Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln 
        115                 120                 125             


Lys Ser Asp Leu Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe 
    130                 135                 140                 


Arg Gly Ile Ser Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu 
145                 150                 155                 160 


Gly Ala Ile Ile Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp 
                165                 170                 175     


Lys Leu Phe Thr Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys 
            180                 185                 190         


Cys Leu Thr Leu Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys 
        195                 200                 205             


Met Gly Ile Glu Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu 
    210                 215                 220                 


Lys Glu Ser Ile Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp 
225                 230                 235                 240 


Leu Glu Asn Ser Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro 
                245                 250                 255     


His Leu Val Leu Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys 
            260                 265                 270         


Lys Ala Ala Met Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His 
        275                 280                 285             


Gln Lys Asp Lys Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe 
    290                 295                 300                 


Leu Gln Thr Thr Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu 
305                 310                 315                 320 


Cys Gly Ile Glu Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln 
                325                 330                 335     


Asn Leu Lys Glu Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln 
            340                 345                 350         


Leu Leu Asn Asn Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val 
        355                 360                 365             


Arg Cys Ser Arg Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met 
    370                 375                 380                 


Gly Val Ile Ala Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys 
385                 390                 395                 400 


Ala Lys Ser Leu Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys 
                405                 410                 415     


Asn Lys Thr Asn Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met 
            420                 425                 430         


Gln Leu Cys Thr Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn 
        435                 440                 445             


Lys Ile Ala Ser Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met 
    450                 455                 460                 


Asn Asp Ile Ala Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys 
465                 470                 475                 480 


Pro Phe Asp Arg Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly 
                485                 490                 495     


Asn Leu Met Glu Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp 
            500                 505                 510         


Tyr Pro Asp Ser Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln 
        515                 520                 525             


Ser Thr Ile Gly Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys 
    530                 535                 540                 


Gln Asp Leu Leu Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val 
545                 550                 555                 560 


Thr Thr Ala Gln Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg 
                565                 570                 575     


Arg Lys Leu Leu Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys 
            580                 585                 590         


Ser Leu His Leu His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly 
        595                 600                 605             


Glu Glu Tyr Pro Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro 
    610                 615                 620                 


Leu Ser Asn Val Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys 
625                 630                 635                 640 


Thr Ile Leu Asn His Val Leu His Val Val Lys Asn Leu Gly Gln Ser 
                645                 650                 655     


Asn Met Asp Ser Glu Asn Thr Arg Asp Ala Gln Gly Gln Phe Leu Thr 
            660                 665                 670         


Val Ile Gly Ala Phe Trp His Leu Thr Lys Glu Arg Lys Tyr Ile Phe 
        675                 680                 685             


Ser Val Arg Met Ala Leu Val Asn Cys Leu Lys Thr Leu Leu Glu Ala 
    690                 695                 700                 


Asp Pro Tyr Ser Lys Trp Ala Ile Leu Asn Val Met Gly Lys Asp Phe 
705                 710                 715                 720 


Pro Val Asn Glu Val Phe Thr Gln Phe Leu Ala Asp Asn His His Gln 
                725                 730                 735     


Val Arg Met Leu Ala Ala Glu Ser Ile Asn Arg Leu Phe Gln Asp Thr 
            740                 745                 750         


Lys Gly Asp Ser Ser Arg Leu Leu Lys Ala Leu Pro Leu Lys Leu Gln 
        755                 760                 765             


Gln Thr Ala Phe Glu Asn Ala Tyr Leu Lys Ala Gln Glu Gly Met Arg 
    770                 775                 780                 


Glu Met Ser His Ser Ala Glu Asn Pro Glu Thr Leu Asp Glu Ile Tyr 
785                 790                 795                 800 


Asn Arg Lys Ser Val Leu Leu Thr Leu Ile Ala Val Val Leu Ser Cys 
                805                 810                 815     


Ser Pro Ile Cys Glu Lys Gln Ala Leu Phe Ala Leu Cys Lys Ser Val 
            820                 825                 830         


Lys Glu Asn Gly Leu Glu Pro His Leu Val Lys Lys Val Leu Glu Lys 
        835                 840                 845             


Val Ser Glu Thr Phe Gly Tyr Arg Arg Leu Glu Asp Phe Met Ala Ser 
    850                 855                 860                 


His Leu Asp Tyr Leu Val Leu Glu Trp Leu Asn Leu Gln Asp Thr Glu 
865                 870                 875                 880 


Tyr Asn Leu Ser Ser Phe Pro Phe Ile Leu Leu Asn Tyr Thr Asn Ile 
                885                 890                 895     


Glu Asp Phe Tyr Arg Ser Cys Tyr Lys Val Leu Ile Pro His Leu Val 
            900                 905                 910         


Ile Arg Ser His Phe Asp Glu Val Lys Ser Ile Ala Asn Gln Ile Gln 
        915                 920                 925             


Glu Asp Trp Lys Ser Leu Leu Thr Asp Cys Phe Pro Lys Ile Leu Val 
    930                 935                 940                 


Asn Ile Leu Pro Tyr Phe Ala Tyr Glu Gly Thr Arg Asp Ser Gly Met 
945                 950                 955                 960 


Ala Gln Gln Arg Glu Thr Ala Thr Lys Val Tyr Asp Met Leu Lys Ser 
                965                 970                 975     


Glu Asn Leu Leu Gly Lys Gln Ile Asp His Leu Phe Ile Ser Asn Leu 
            980                 985                 990         


Pro Glu Ile Val Val Glu Leu Leu  Met Thr Leu His Glu  Pro Ala Asn 
        995                 1000                 1005             


Ser Ser  Ala Ser Gln Ser Thr  Asp Leu Cys Asp Phe  Ser Gly Asp 
    1010                 1015                 1020             


Leu Asp  Pro Ala Pro Asn Pro  Pro His Phe Pro Ser  His Val Ile 
    1025                 1030                 1035             


Lys Ala  Thr Phe Ala Tyr Ile  Ser Asn Cys His Lys  Thr Lys Leu 
    1040                 1045                 1050             


Lys Ser  Ile Leu Glu Ile Leu  Ser Lys Ser Pro Asp  Ser Tyr Gln 
    1055                 1060                 1065             


Lys Ile  Leu Leu Ala Ile Cys  Glu Gln Ala Ala Glu  Thr Asn Asn 
    1070                 1075                 1080             


Val Tyr  Lys Lys His Arg Ile  Leu Lys Ile Tyr His  Leu Phe Val 
    1085                 1090                 1095             


Ser Leu  Leu Leu Lys Asp Ile  Lys Ser Gly Leu Gly  Gly Ala Trp 
    1100                 1105                 1110             


Ala Phe  Val Leu Arg Asp Val  Ile Tyr Thr Leu Ile  His Tyr Ile 
    1115                 1120                 1125             


Asn Gln  Arg Pro Ser Cys Ile  Met Asp Val Ser Leu  Arg Ser Phe 
    1130                 1135                 1140             


Ser Leu  Cys Cys Asp Leu Leu  Ser Gln Val Cys Gln  Thr Ala Val 
    1145                 1150                 1155             


Thr Tyr  Cys Lys Asp Ala Leu  Glu Asn His Leu His  Val Ile Val 
    1160                 1165                 1170             


Gly Thr  Leu Ile Pro Leu Val  Tyr Glu Gln Val Glu  Val Gln Lys 
    1175                 1180                 1185             


Gln Val  Leu Asp Leu Leu Lys  Tyr Leu Val Ile Asp  Asn Lys Asp 
    1190                 1195                 1200             


Asn Glu  Asn Leu Tyr Ile Thr  Ile Lys Leu Leu Asp  Pro Phe Pro 
    1205                 1210                 1215             


Asp His  Val Val Phe Lys Asp  Leu Arg Ile Thr Gln  Gln Lys Ile 
    1220                 1225                 1230             


Lys Tyr  Ser Arg Gly Pro Phe  Ser Leu Leu Glu Glu  Ile Asn His 
    1235                 1240                 1245             


Phe Leu  Ser Val Ser Val Tyr  Asp Ala Leu Pro Leu  Thr Arg Leu 
    1250                 1255                 1260             


Glu Gly  Leu Lys Asp Leu Arg  Arg Gln Leu Glu Leu  His Lys Asp 
    1265                 1270                 1275             


Gln Met  Val Asp Ile Met Arg  Ala Ser Gln Asp Asn  Pro Gln Asp 
    1280                 1285                 1290             


Gly Ile  Met Val Lys Leu Val  Val Asn Leu Leu Gln  Leu Ser Lys 
    1295                 1300                 1305             


Met Ala  Ile Asn His Thr Gly  Glu Lys Glu Val Leu  Glu Ala Val 
    1310                 1315                 1320             


Gly Ser  Cys Leu Gly Glu Val  Gly Pro Ile Asp Phe  Ser Thr Ile 
    1325                 1330                 1335             


Ala Ile  Gln His Ser Lys Asp  Ala Ser Tyr Thr Lys  Ala Leu Lys 
    1340                 1345                 1350             


Leu Phe  Glu Asp Lys Glu Leu  Gln Trp Thr Phe Ile  Met Leu Thr 
    1355                 1360                 1365             


Tyr Leu  Asn Asn Thr Leu Val  Glu Asp Cys Val Lys  Val Arg Ser 
    1370                 1375                 1380             


Ala Ala  Val Thr Cys Leu Lys  Asn Ile Leu Ala Thr  Lys Thr Gly 
    1385                 1390                 1395             


His Ser  Phe Trp Glu Ile Tyr  Lys Met Thr Thr Asp  Pro Met Leu 
    1400                 1405                 1410             


Ala Tyr  Leu Gln Pro Phe Arg  Thr Ser Arg Lys Lys  Phe Leu Glu 
    1415                 1420                 1425             


Val Pro  Arg Phe Asp Lys Glu  Asn Pro Phe Glu Gly  Leu Asp Asp 
    1430                 1435                 1440             


Ile Asn  Leu Trp Ile Pro Leu  Ser Glu Asn His Asp  Ile Trp Ile 
    1445                 1450                 1455             


Lys Thr  Leu Thr Cys Ala Phe  Leu Asp Ser Gly Gly  Thr Lys Cys 
    1460                 1465                 1470             


Glu Ile  Leu Gln Leu Leu Lys  Pro Met Cys Glu Val  Lys Thr Asp 
    1475                 1480                 1485             


Phe Cys  Gln Thr Val Leu Pro  Tyr Leu Ile His Asp  Ile Leu Leu 
    1490                 1495                 1500             


Gln Asp  Thr Asn Glu Ser Trp  Arg Asn Leu Leu Ser  Thr His Val 
    1505                 1510                 1515             


Gln Gly  Phe Phe Thr Ser Cys  Leu Arg His Phe Ser  Gln Thr Ser 
    1520                 1525                 1530             


Arg Ser  Thr Thr Pro Ala Asn  Leu Asp Ser Glu Ser  Glu His Phe 
    1535                 1540                 1545             


Phe Arg  Cys Cys Leu Asp Lys  Lys Ser Gln Arg Thr  Met Leu Ala 
    1550                 1555                 1560             


Val Val  Asp Tyr Met Arg Arg  Gln Lys Arg Pro Ser  Ser Gly Thr 
    1565                 1570                 1575             


Ile Phe  Asn Asp Ala Phe Trp  Leu Asp Leu Asn Tyr  Leu Glu Val 
    1580                 1585                 1590             


Ala Lys  Val Ala Gln Ser Cys  Ala Ala His Phe Thr  Ala Leu Leu 
    1595                 1600                 1605             


Tyr Ala  Glu Ile Tyr Ala Asp  Lys Lys Ser Met Asp  Asp Gln Glu 
    1610                 1615                 1620             


Lys Arg  Ser Leu Ala Phe Glu  Glu Gly Ser Gln Ser  Thr Thr Ile 
    1625                 1630                 1635             


Ser Ser  Leu Ser Glu Lys Ser  Lys Glu Glu Thr Gly  Ile Ser Leu 
    1640                 1645                 1650             


Gln Asp  Leu Leu Leu Glu Ile  Tyr Arg Ser Ile Gly  Glu Pro Asp 
    1655                 1660                 1665             


Ser Leu  Tyr Gly Cys Gly Gly  Gly Lys Met Leu Gln  Pro Ile Thr 
    1670                 1675                 1680             


Arg Leu  Arg Thr Tyr Glu His  Glu Ala Met Trp Gly  Lys Ala Leu 
    1685                 1690                 1695             


Val Thr  Tyr Asp Leu Glu Thr  Ala Ile Pro Ser Ser  Thr Arg Gln 
    1700                 1705                 1710             


Ala Gly  Ile Ile Gln Ala Leu  Gln Asn Leu Gly Leu  Cys His Ile 
    1715                 1720                 1725             


Leu Ser  Val Tyr Leu Lys Gly  Leu Asp Tyr Glu Asn  Lys Asp Trp 
    1730                 1735                 1740             


Cys Pro  Glu Leu Glu Glu Leu  His Tyr Gln Ala Ala  Trp Arg Asn 
    1745                 1750                 1755             


Met Gln  Trp Asp His Cys Thr  Ser Val Ser Lys Glu  Val Glu Gly 
    1760                 1765                 1770             


Thr Ser  Tyr His Glu Ser Leu  Tyr Asn Ala Leu Gln  Ser Leu Arg 
    1775                 1780                 1785             


Asp Arg  Glu Phe Ser Thr Phe  Tyr Glu Ser Leu Lys  Tyr Ala Arg 
    1790                 1795                 1800             


Val Lys  Glu Val Glu Glu Met  Cys Lys Arg Ser Leu  Glu Ser Val 
    1805                 1810                 1815             


Tyr Ser  Leu Tyr Pro Thr Leu  Ser Arg Leu Gln Ala  Ile Gly Glu 
    1820                 1825                 1830             


Leu Glu  Ser Ile Gly Glu Leu  Phe Ser Arg Ser Val  Thr His Arg 
    1835                 1840                 1845             


Gln Leu  Ser Glu Val Tyr Ile  Lys Trp Gln Lys His  Ser Gln Leu 
    1850                 1855                 1860             


Leu Lys  Asp Ser Asp Phe Ser  Phe Gln Glu Pro Ile  Met Ala Leu 
    1865                 1870                 1875             


Arg Thr  Val Ile Leu Glu Ile  Leu Met Glu Lys Glu  Met Asp Asn 
    1880                 1885                 1890             


Ser Gln  Arg Glu Cys Ile Lys  Asp Ile Leu Thr Lys  His Leu Val 
    1895                 1900                 1905             


Glu Leu  Ser Ile Leu Ala Arg  Thr Phe Lys Asn Thr  Gln Leu Pro 
    1910                 1915                 1920             


Glu Arg  Ala Ile Phe Gln Ile  Lys Gln Tyr Asn Ser  Val Ser Cys 
    1925                 1930                 1935             


Gly Val  Ser Glu Trp Gln Leu  Glu Glu Ala Gln Val  Phe Trp Ala 
    1940                 1945                 1950             


Lys Lys  Glu Gln Ser Leu Ala  Leu Ser Ile Leu Lys  Gln Met Ile 
    1955                 1960                 1965             


Lys Lys  Leu Asp Ala Ser Cys  Ala Ala Asn Asn Pro  Ser Leu Lys 
    1970                 1975                 1980             


Leu Thr  Tyr Thr Glu Cys Leu  Arg Val Cys Gly Asn  Trp Leu Ala 
    1985                 1990                 1995             


Glu Thr  Cys Leu Glu Asn Pro  Ala Val Ile Met Gln  Thr Tyr Leu 
    2000                 2005                 2010             


Glu Lys  Ala Val Glu Val Ala  Gly Asn Tyr Asp Gly  Glu Ser Ser 
    2015                 2020                 2025             


Asp Glu  Leu Arg Asn Gly Lys  Met Lys Ala Phe Leu  Ser Leu Ala 
    2030                 2035                 2040             


Arg Phe  Ser Asp Thr Gln Tyr  Gln Arg Ile Glu Asn  Tyr Met Lys 
    2045                 2050                 2055             


Ser Ser  Glu Phe Glu Asn Lys  Gln Ala Leu Leu Lys  Arg Ala Lys 
    2060                 2065                 2070             


Glu Glu  Val Gly Leu Leu Arg  Glu His Lys Ile Gln  Thr Asn Arg 
    2075                 2080                 2085             


Tyr Thr  Val Lys Val Gln Arg  Glu Leu Glu Leu Asp  Glu Leu Ala 
    2090                 2095                 2100             


Leu Arg  Ala Leu Lys Glu Asp  Arg Lys Arg Phe Leu  Cys Lys Ala 
    2105                 2110                 2115             


Val Glu  Asn Tyr Ile Asn Cys  Leu Leu Ser Gly Glu  Glu His Asp 
    2120                 2125                 2130             


Met Trp  Val Phe Arg Leu Cys  Ser Leu Trp Leu Glu  Asn Ser Gly 
    2135                 2140                 2145             


Val Ser  Glu Val Asn Gly Met  Met Lys Arg Asp Gly  Met Lys Ile 
    2150                 2155                 2160             


Pro Thr  Tyr Lys Phe Leu Pro  Leu Met Tyr Gln Leu  Ala Ala Arg 
    2165                 2170                 2175             


Met Gly  Thr Lys Met Met Gly  Gly Leu Gly Phe His  Glu Val Leu 
    2180                 2185                 2190             


Asn Asn  Leu Ile Ser Arg Ile  Ser Met Asp His Pro  His His Thr 
    2195                 2200                 2205             


Leu Phe  Ile Ile Leu Ala Leu  Ala Asn Ala Asn Arg  Asp Glu Phe 
    2210                 2215                 2220             


Leu Thr  Lys Pro Glu Val Ala  Arg Arg Ser Arg Ile  Thr Lys Asn 
    2225                 2230                 2235             


Val Pro  Lys Gln Ser Ser Gln  Leu Asp Glu Asp Arg  Thr Glu Ala 
    2240                 2245                 2250             


Ala Asn  Arg Ile Ile Cys Thr  Ile Arg Ser Arg Arg  Pro Gln Met 
    2255                 2260                 2265             


Val Arg  Ser Val Glu Ala Leu  Cys Asp Ala Tyr Ile  Ile Leu Ala 
    2270                 2275                 2280             


Asn Leu  Asp Ala Thr Gln Trp  Lys Thr Gln Arg Lys  Gly Ile Asn 
    2285                 2290                 2295             


Ile Pro  Ala Asp Gln Pro Ile  Thr Lys Leu Lys Asn  Leu Glu Asp 
    2300                 2305                 2310             


Val Val  Val Pro Thr Met Glu  Ile Lys Val Asp His  Thr Gly Glu 
    2315                 2320                 2325             


Tyr Gly  Asn Leu Val Thr Ile  Gln Ser Phe Lys Ala  Glu Phe Arg 
    2330                 2335                 2340             


Leu Ala  Gly Gly Val Asn Leu  Pro Lys Ile Ile Asp  Cys Val Gly 
    2345                 2350                 2355             


Ser Asp  Gly Lys Glu Arg Arg  Gln Leu Val Lys Gly  Arg Asp Asp 
    2360                 2365                 2370             


Leu Arg  Gln Asp Ala Val Met  Gln Gln Val Phe Gln  Met Cys Asn 
    2375                 2380                 2385             


Thr Leu  Leu Gln Arg Asn Thr  Glu Thr Arg Lys Arg  Lys Leu Thr 
    2390                 2395                 2400             


Ile Cys  Thr Tyr Lys Val Val  Pro Leu Ser Gln Arg  Ser Gly Val 
    2405                 2410                 2415             


Leu Glu  Trp Cys Thr Gly Thr  Val Pro Ile Gly Glu  Phe Leu Val 
    2420                 2425                 2430             


Asn Asn  Glu Asp Gly Ala His  Lys Arg Tyr Arg Pro  Asn Asp Phe 
    2435                 2440                 2445             


Ser Ala  Phe Gln Cys Gln Lys  Lys Met Met Glu Val  Gln Lys Lys 
    2450                 2455                 2460             


Ser Phe  Glu Glu Lys Tyr Glu  Val Phe Met Asp Val  Cys Gln Asn 
    2465                 2470                 2475             


Phe Gln  Pro Val Phe Arg Tyr  Phe Cys Met Glu Lys  Phe Leu Asp 
    2480                 2485                 2490             


Pro Ala  Ile Trp Phe Glu Lys  Arg Leu Ala Tyr Thr  Arg Ser Val 
    2495                 2500                 2505             


Ala Thr  Ser Ser Ile Val Gly  Tyr Ile Leu Gly Leu  Gly Asp Arg 
    2510                 2515                 2520             


His Val  Gln Asn Ile Leu Ile  Asn Glu Gln Ser Ala  Glu Leu Val 
    2525                 2530                 2535             


His Ile  Asp Leu Gly Val Ala  Phe Glu Gln Gly Lys  Ile Leu Pro 
    2540                 2545                 2550             


Thr Pro  Glu Thr Val Pro Phe  Arg Leu Thr Arg Asp  Ile Val Asp 
    2555                 2560                 2565             


Gly Met  Gly Ile Thr Gly Val  Glu Gly Val Phe Arg  Arg Cys Cys 
    2570                 2575                 2580             


Glu Lys  Thr Met Glu Val Met  Arg Asn Ser Gln Glu  Thr Leu Leu 
    2585                 2590                 2595             


Thr Ile  Val Glu Val Leu Leu  Tyr Asp Pro Leu Phe  Asp Trp Thr 
    2600                 2605                 2610             


Met Asn  Pro Leu Lys Ala Leu  Tyr Leu Gln Gln Arg  Pro Glu Asp 
    2615                 2620                 2625             


Glu Thr  Glu Leu His Pro Thr  Leu Asn Ala Asp Asp  Gln Glu Cys 
    2630                 2635                 2640             


Lys Arg  Asn Leu Ser Asp Ile  Asp Gln Ser Phe Asn  Lys Val Ala 
    2645                 2650                 2655             


Glu Arg  Val Leu Met Arg Leu  Gln Glu Lys Leu Lys  Gly Val Glu 
    2660                 2665                 2670             


Glu Gly  Thr Val Leu Ser Val  Gly Gly Gln Val Asn  Leu Leu Ile 
    2675                 2680                 2685             


Gln Gln  Ala Ile Asp Pro Lys  Asn Leu Ser Arg Leu  Phe Pro Gly 
    2690                 2695                 2700             


Trp Lys  Ala Trp Val 
    2705             


<210>  65
<211>  2620
<212>  PRT
<213>  homo sapiens

<400>  65

Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His Gly Glu Arg Thr 
1               5                   10                  15      


Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu Cys Gln Asp Lys 
            20                  25                  30          


Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu Leu Lys Leu Trp 
        35                  40                  45              


Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser Ser Glu Gln Ile 
    50                  55                  60                  


Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile Gln Gly Ser Leu 
65                  70                  75                  80  


Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr Gly Ser Ala Cys 
                85                  90                  95      


Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu Ala Leu Thr Thr 
            100                 105                 110         


Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu Gln Asn Met Cys 
        115                 120                 125             


Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile Met Lys Trp Leu 
    130                 135                 140                 


Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser Thr Glu Val Pro 
145                 150                 155                 160 


Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu Glu Lys Ile Leu 
                165                 170                 175     


Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met Asn Phe Phe Gln 
            180                 185                 190         


Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys Glu Glu Leu Ser 
        195                 200                 205             


Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr Phe Asp Lys Met 
    210                 215                 220                 


Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu Lys His Gln Ser 
225                 230                 235                 240 


Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu Ser Leu Asp Arg 
                245                 250                 255     


Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn Tyr Ser Ser Glu 
            260                 265                 270         


Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg Leu Leu Val Gly 
        275                 280                 285             


Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala Glu Glu Glu Ala 
    290                 295                 300                 


Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu Met Gln Cys Ala 
305                 310                 315                 320 


Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn Glu Glu Phe Arg 
                325                 330                 335     


Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr Arg Cys Leu Ser 
            340                 345                 350         


Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser Gly Phe Phe Leu 
        355                 360                 365             


Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala Asp Ile Cys Lys 
    370                 375                 380                 


Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg Gly Glu Val Glu 
385                 390                 395                 400 


Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu Val Glu Asp Gln 
                405                 410                 415     


Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser Ser Val Ser Asp 
            420                 425                 430         


Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly Ala Ile Asn Pro 
        435                 440                 445             


Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu Phe Leu Asp Met 
    450                 455                 460                 


Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln Thr Asn Thr Val 
465                 470                 475                 480 


Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu Met Leu Ile Asp 
                485                 490                 495     


Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu His Met Tyr Leu 
            500                 505                 510         


Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro Leu Pro Met Glu 
        515                 520                 525             


Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val Cys Ser Leu Tyr 
    530                 535                 540                 


Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn His Val Leu His 
545                 550                 555                 560 


Val Val Lys Asn Leu Gly Gln Ser Asn Met Asp Ser Glu Asn Thr Arg 
                565                 570                 575     


Asp Ala Gln Gly Gln Phe Leu Thr Val Ile Gly Ala Phe Trp His Leu 
            580                 585                 590         


Thr Lys Glu Arg Lys Tyr Ile Phe Ser Val Arg Met Ala Leu Val Asn 
        595                 600                 605             


Cys Leu Lys Thr Leu Leu Glu Ala Asp Pro Tyr Ser Lys Trp Ala Ile 
    610                 615                 620                 


Leu Asn Val Met Gly Lys Asp Phe Pro Val Asn Glu Val Phe Thr Gln 
625                 630                 635                 640 


Phe Leu Ala Asp Asn His His Gln Val Arg Met Leu Ala Ala Glu Ser 
                645                 650                 655     


Ile Asn Arg Leu Phe Gln Asp Thr Lys Gly Asp Ser Ser Arg Leu Leu 
            660                 665                 670         


Lys Ala Leu Pro Leu Lys Leu Gln Gln Thr Ala Phe Glu Asn Ala Tyr 
        675                 680                 685             


Leu Lys Ala Gln Glu Gly Met Arg Glu Met Ser His Ser Ala Glu Asn 
    690                 695                 700                 


Pro Glu Thr Leu Asp Glu Ile Tyr Asn Arg Lys Ser Val Leu Leu Thr 
705                 710                 715                 720 


Leu Ile Ala Val Val Leu Ser Cys Ser Pro Ile Cys Glu Lys Gln Ala 
                725                 730                 735     


Leu Phe Ala Leu Cys Lys Ser Val Lys Glu Asn Gly Leu Glu Pro His 
            740                 745                 750         


Leu Val Lys Lys Val Leu Glu Lys Val Ser Glu Thr Phe Gly Tyr Arg 
        755                 760                 765             


Arg Leu Glu Asp Phe Met Ala Ser His Leu Asp Tyr Leu Val Leu Glu 
    770                 775                 780                 


Trp Leu Asn Leu Gln Asp Thr Glu Tyr Asn Leu Ser Ser Phe Pro Phe 
785                 790                 795                 800 


Ile Leu Leu Asn Tyr Thr Asn Ile Glu Asp Phe Tyr Arg Ser Cys Tyr 
                805                 810                 815     


Lys Val Leu Ile Pro His Leu Val Ile Arg Ser His Phe Asp Glu Val 
            820                 825                 830         


Lys Ser Ile Ala Asn Gln Ile Gln Glu Asp Trp Lys Ser Leu Leu Thr 
        835                 840                 845             


Asp Cys Phe Pro Lys Ile Leu Val Asn Ile Leu Pro Tyr Phe Ala Tyr 
    850                 855                 860                 


Glu Gly Thr Arg Asp Ser Gly Met Ala Gln Gln Arg Glu Thr Ala Thr 
865                 870                 875                 880 


Lys Val Tyr Asp Met Leu Lys Ser Glu Asn Leu Leu Gly Lys Gln Ile 
                885                 890                 895     


Asp His Leu Phe Ile Ser Asn Leu Pro Glu Ile Val Val Glu Leu Leu 
            900                 905                 910         


Met Thr Leu His Glu Pro Ala Asn Ser Ser Ala Ser Gln Ser Thr Asp 
        915                 920                 925             


Leu Cys Asp Phe Ser Gly Asp Leu Asp Pro Ala Pro Asn Pro Pro His 
    930                 935                 940                 


Phe Pro Ser His Val Ile Lys Ala Thr Phe Ala Tyr Ile Ser Asn Cys 
945                 950                 955                 960 


His Lys Thr Lys Leu Lys Ser Ile Leu Glu Ile Leu Ser Lys Ser Pro 
                965                 970                 975     


Asp Ser Tyr Gln Lys Ile Leu Leu Ala Ile Cys Glu Gln Ala Ala Glu 
            980                 985                 990         


Thr Asn Asn Val Tyr Lys Lys His  Arg Ile Leu Lys Ile  Tyr His Leu 
        995                 1000                 1005             


Phe Val  Ser Leu Leu Leu Lys  Asp Ile Lys Ser Gly  Leu Gly Gly 
    1010                 1015                 1020             


Ala Trp  Ala Phe Val Leu Arg  Asp Val Ile Tyr Thr  Leu Ile His 
    1025                 1030                 1035             


Tyr Ile  Asn Gln Arg Pro Ser  Cys Ile Met Asp Val  Ser Leu Arg 
    1040                 1045                 1050             


Ser Phe  Ser Leu Cys Cys Asp  Leu Leu Ser Gln Val  Cys Gln Thr 
    1055                 1060                 1065             


Ala Val  Thr Tyr Cys Lys Asp  Ala Leu Glu Asn His  Leu His Val 
    1070                 1075                 1080             


Ile Val  Gly Thr Leu Ile Pro  Leu Val Tyr Glu Gln  Val Glu Val 
    1085                 1090                 1095             


Gln Lys  Gln Val Leu Asp Leu  Leu Lys Tyr Leu Val  Ile Asp Asn 
    1100                 1105                 1110             


Lys Asp  Asn Glu Asn Leu Tyr  Ile Thr Ile Lys Leu  Leu Asp Pro 
    1115                 1120                 1125             


Phe Pro  Asp His Val Val Phe  Lys Asp Leu Arg Ile  Thr Gln Gln 
    1130                 1135                 1140             


Lys Ile  Lys Tyr Ser Arg Gly  Pro Phe Ser Leu Leu  Glu Glu Ile 
    1145                 1150                 1155             


Asn His  Phe Leu Ser Val Ser  Val Tyr Asp Ala Leu  Pro Leu Thr 
    1160                 1165                 1170             


Arg Leu  Glu Gly Leu Lys Asp  Leu Arg Arg Gln Leu  Glu Leu His 
    1175                 1180                 1185             


Lys Asp  Gln Met Val Asp Ile  Met Arg Ala Ser Gln  Asp Asn Pro 
    1190                 1195                 1200             


Gln Asp  Gly Ile Met Val Lys  Leu Val Val Asn Leu  Leu Gln Leu 
    1205                 1210                 1215             


Ser Lys  Met Ala Ile Asn His  Thr Gly Glu Lys Glu  Val Leu Glu 
    1220                 1225                 1230             


Ala Val  Gly Ser Cys Leu Gly  Glu Val Gly Pro Ile  Asp Phe Ser 
    1235                 1240                 1245             


Thr Ile  Ala Ile Gln His Ser  Lys Asp Ala Ser Tyr  Thr Lys Ala 
    1250                 1255                 1260             


Leu Lys  Leu Phe Glu Asp Lys  Glu Leu Gln Trp Thr  Phe Ile Met 
    1265                 1270                 1275             


Leu Thr  Tyr Leu Asn Asn Thr  Leu Val Glu Asp Cys  Val Lys Val 
    1280                 1285                 1290             


Arg Ser  Ala Ala Val Thr Cys  Leu Lys Asn Ile Leu  Ala Thr Lys 
    1295                 1300                 1305             


Thr Gly  His Ser Phe Trp Glu  Ile Tyr Lys Met Thr  Thr Asp Pro 
    1310                 1315                 1320             


Met Leu  Ala Tyr Leu Gln Pro  Phe Arg Thr Ser Arg  Lys Lys Phe 
    1325                 1330                 1335             


Leu Glu  Val Pro Arg Phe Asp  Lys Glu Asn Pro Phe  Glu Gly Leu 
    1340                 1345                 1350             


Asp Asp  Ile Asn Leu Trp Ile  Pro Leu Ser Glu Asn  His Asp Ile 
    1355                 1360                 1365             


Trp Ile  Lys Thr Leu Thr Cys  Ala Phe Leu Asp Ser  Gly Gly Thr 
    1370                 1375                 1380             


Lys Cys  Glu Ile Leu Gln Leu  Leu Lys Pro Met Cys  Glu Val Lys 
    1385                 1390                 1395             


Thr Asp  Phe Cys Gln Thr Val  Leu Pro Tyr Leu Ile  His Asp Ile 
    1400                 1405                 1410             


Leu Leu  Gln Asp Thr Asn Glu  Ser Trp Arg Asn Leu  Leu Ser Thr 
    1415                 1420                 1425             


His Val  Gln Gly Phe Phe Thr  Ser Cys Leu Arg His  Phe Ser Gln 
    1430                 1435                 1440             


Thr Ser  Arg Ser Thr Thr Pro  Ala Asn Leu Asp Ser  Glu Ser Glu 
    1445                 1450                 1455             


His Phe  Phe Arg Cys Cys Leu  Asp Lys Lys Ser Gln  Arg Thr Met 
    1460                 1465                 1470             


Leu Ala  Val Val Asp Tyr Met  Arg Arg Gln Lys Arg  Pro Ser Ser 
    1475                 1480                 1485             


Gly Thr  Ile Phe Asn Asp Ala  Phe Trp Leu Asp Leu  Asn Tyr Leu 
    1490                 1495                 1500             


Glu Val  Ala Lys Val Ala Gln  Ser Cys Ala Ala His  Phe Thr Ala 
    1505                 1510                 1515             


Leu Leu  Tyr Ala Glu Ile Tyr  Ala Asp Lys Lys Ser  Met Asp Asp 
    1520                 1525                 1530             


Gln Glu  Lys Arg Ser Leu Ala  Phe Glu Glu Gly Ser  Gln Ser Thr 
    1535                 1540                 1545             


Thr Ile  Ser Ser Leu Ser Glu  Lys Ser Lys Glu Glu  Thr Gly Ile 
    1550                 1555                 1560             


Ser Leu  Gln Asp Leu Leu Leu  Glu Ile Tyr Arg Ser  Ile Gly Glu 
    1565                 1570                 1575             


Pro Asp  Ser Leu Tyr Gly Cys  Gly Gly Gly Lys Met  Leu Gln Pro 
    1580                 1585                 1590             


Ile Thr  Arg Leu Arg Thr Tyr  Glu His Glu Ala Met  Trp Gly Lys 
    1595                 1600                 1605             


Ala Leu  Val Thr Tyr Asp Leu  Glu Thr Ala Ile Pro  Ser Ser Thr 
    1610                 1615                 1620             


Arg Gln  Ala Gly Ile Ile Gln  Ala Leu Gln Asn Leu  Gly Leu Cys 
    1625                 1630                 1635             


His Ile  Leu Ser Val Tyr Leu  Lys Gly Leu Asp Tyr  Glu Asn Lys 
    1640                 1645                 1650             


Asp Trp  Cys Pro Glu Leu Glu  Glu Leu His Tyr Gln  Ala Ala Trp 
    1655                 1660                 1665             


Arg Asn  Met Gln Trp Asp His  Cys Thr Ser Val Ser  Lys Glu Val 
    1670                 1675                 1680             


Glu Gly  Thr Ser Tyr His Glu  Ser Leu Tyr Asn Ala  Leu Gln Ser 
    1685                 1690                 1695             


Leu Arg  Asp Arg Glu Phe Ser  Thr Phe Tyr Glu Ser  Leu Lys Tyr 
    1700                 1705                 1710             


Ala Arg  Val Lys Glu Val Glu  Glu Met Cys Lys Arg  Ser Leu Glu 
    1715                 1720                 1725             


Ser Val  Tyr Ser Leu Tyr Pro  Thr Leu Ser Arg Leu  Gln Ala Ile 
    1730                 1735                 1740             


Gly Glu  Leu Glu Ser Ile Gly  Glu Leu Phe Ser Arg  Ser Val Thr 
    1745                 1750                 1755             


His Arg  Gln Leu Ser Glu Val  Tyr Ile Lys Trp Gln  Lys His Ser 
    1760                 1765                 1770             


Gln Leu  Leu Lys Asp Ser Asp  Phe Ser Phe Gln Glu  Pro Ile Met 
    1775                 1780                 1785             


Ala Leu  Arg Thr Val Ile Leu  Glu Ile Leu Met Glu  Lys Glu Met 
    1790                 1795                 1800             


Asp Asn  Ser Gln Arg Glu Cys  Ile Lys Asp Ile Leu  Thr Lys His 
    1805                 1810                 1815             


Leu Val  Glu Leu Ser Ile Leu  Ala Arg Thr Phe Lys  Asn Thr Gln 
    1820                 1825                 1830             


Leu Pro  Glu Arg Ala Ile Phe  Gln Ile Lys Gln Tyr  Asn Ser Val 
    1835                 1840                 1845             


Ser Cys  Gly Val Ser Glu Trp  Gln Leu Glu Glu Ala  Gln Val Phe 
    1850                 1855                 1860             


Trp Ala  Lys Lys Glu Gln Ser  Leu Ala Leu Ser Ile  Leu Lys Gln 
    1865                 1870                 1875             


Met Ile  Lys Lys Leu Asp Ala  Ser Cys Ala Ala Asn  Asn Pro Ser 
    1880                 1885                 1890             


Leu Lys  Leu Thr Tyr Thr Glu  Cys Leu Arg Val Cys  Gly Asn Trp 
    1895                 1900                 1905             


Leu Ala  Glu Thr Cys Leu Glu  Asn Pro Ala Val Ile  Met Gln Thr 
    1910                 1915                 1920             


Tyr Leu  Glu Lys Ala Val Glu  Val Ala Gly Asn Tyr  Asp Gly Glu 
    1925                 1930                 1935             


Ser Ser  Asp Glu Leu Arg Asn  Gly Lys Met Lys Ala  Phe Leu Ser 
    1940                 1945                 1950             


Leu Ala  Arg Phe Ser Asp Thr  Gln Tyr Gln Arg Ile  Glu Asn Tyr 
    1955                 1960                 1965             


Met Lys  Ser Ser Glu Phe Glu  Asn Lys Gln Ala Leu  Leu Lys Arg 
    1970                 1975                 1980             


Ala Lys  Glu Glu Val Gly Leu  Leu Arg Glu His Lys  Ile Gln Thr 
    1985                 1990                 1995             


Asn Arg  Tyr Thr Val Lys Val  Gln Arg Glu Leu Glu  Leu Asp Glu 
    2000                 2005                 2010             


Leu Ala  Leu Arg Ala Leu Lys  Glu Asp Arg Lys Arg  Phe Leu Cys 
    2015                 2020                 2025             


Lys Ala  Val Glu Asn Tyr Ile  Asn Cys Leu Leu Ser  Gly Glu Glu 
    2030                 2035                 2040             


His Asp  Met Trp Val Phe Arg  Leu Cys Ser Leu Trp  Leu Glu Asn 
    2045                 2050                 2055             


Ser Gly  Val Ser Glu Val Asn  Gly Met Met Lys Arg  Asp Gly Met 
    2060                 2065                 2070             


Lys Ile  Pro Thr Tyr Lys Phe  Leu Pro Leu Met Tyr  Gln Leu Ala 
    2075                 2080                 2085             


Ala Arg  Met Gly Thr Lys Met  Met Gly Gly Leu Gly  Phe His Glu 
    2090                 2095                 2100             


Val Leu  Asn Asn Leu Ile Ser  Arg Ile Ser Met Asp  His Pro His 
    2105                 2110                 2115             


His Thr  Leu Phe Ile Ile Leu  Ala Leu Ala Asn Ala  Asn Arg Asp 
    2120                 2125                 2130             


Glu Phe  Leu Thr Lys Pro Glu  Val Ala Arg Arg Ser  Arg Ile Thr 
    2135                 2140                 2145             


Lys Asn  Val Pro Lys Gln Ser  Ser Gln Leu Asp Glu  Asp Arg Thr 
    2150                 2155                 2160             


Glu Ala  Ala Asn Arg Ile Ile  Cys Thr Ile Arg Ser  Arg Arg Pro 
    2165                 2170                 2175             


Gln Met  Val Arg Ser Val Glu  Ala Leu Cys Asp Ala  Tyr Ile Ile 
    2180                 2185                 2190             


Leu Ala  Asn Leu Asp Ala Thr  Gln Trp Lys Thr Gln  Arg Lys Gly 
    2195                 2200                 2205             


Ile Asn  Ile Pro Ala Asp Gln  Pro Ile Thr Lys Leu  Lys Asn Leu 
    2210                 2215                 2220             


Glu Asp  Val Val Val Pro Thr  Met Glu Ile Lys Val  Asp His Thr 
    2225                 2230                 2235             


Gly Glu  Tyr Gly Asn Leu Val  Thr Ile Gln Ser Phe  Lys Ala Glu 
    2240                 2245                 2250             


Phe Arg  Leu Ala Gly Gly Val  Asn Leu Pro Lys Ile  Ile Asp Cys 
    2255                 2260                 2265             


Val Gly  Ser Asp Gly Lys Glu  Arg Arg Gln Leu Val  Lys Gly Arg 
    2270                 2275                 2280             


Asp Asp  Leu Arg Gln Asp Ala  Val Met Gln Gln Val  Phe Gln Met 
    2285                 2290                 2295             


Cys Asn  Thr Leu Leu Gln Arg  Asn Thr Glu Thr Arg  Lys Arg Lys 
    2300                 2305                 2310             


Leu Thr  Ile Cys Thr Tyr Lys  Val Val Pro Leu Ser  Gln Arg Ser 
    2315                 2320                 2325             


Gly Val  Leu Glu Trp Cys Thr  Gly Thr Val Pro Ile  Gly Glu Phe 
    2330                 2335                 2340             


Leu Val  Asn Asn Glu Asp Gly  Ala His Lys Arg Tyr  Arg Pro Asn 
    2345                 2350                 2355             


Asp Phe  Ser Ala Phe Gln Cys  Gln Lys Lys Met Met  Glu Val Gln 
    2360                 2365                 2370             


Lys Lys  Ser Phe Glu Glu Lys  Tyr Glu Val Phe Met  Asp Val Cys 
    2375                 2380                 2385             


Gln Asn  Phe Gln Pro Val Phe  Arg Tyr Phe Cys Met  Glu Lys Phe 
    2390                 2395                 2400             


Leu Asp  Pro Ala Ile Trp Phe  Glu Lys Arg Leu Ala  Tyr Thr Arg 
    2405                 2410                 2415             


Ser Val  Ala Thr Ser Ser Ile  Val Gly Tyr Ile Leu  Gly Leu Gly 
    2420                 2425                 2430             


Asp Arg  His Val Gln Asn Ile  Leu Ile Asn Glu Gln  Ser Ala Glu 
    2435                 2440                 2445             


Leu Val  His Ile Asp Leu Gly  Val Ala Phe Glu Gln  Gly Lys Ile 
    2450                 2455                 2460             


Leu Pro  Thr Pro Glu Thr Val  Pro Phe Arg Leu Thr  Arg Asp Ile 
    2465                 2470                 2475             


Val Asp  Gly Met Gly Ile Thr  Gly Val Glu Gly Val  Phe Arg Arg 
    2480                 2485                 2490             


Cys Cys  Glu Lys Thr Met Glu  Val Met Arg Asn Ser  Gln Glu Thr 
    2495                 2500                 2505             


Leu Leu  Thr Ile Val Glu Val  Leu Leu Tyr Asp Pro  Leu Phe Asp 
    2510                 2515                 2520             


Trp Thr  Met Asn Pro Leu Lys  Ala Leu Tyr Leu Gln  Gln Arg Pro 
    2525                 2530                 2535             


Glu Asp  Glu Thr Glu Leu His  Pro Thr Leu Asn Ala  Asp Asp Gln 
    2540                 2545                 2550             


Glu Cys  Lys Arg Asn Leu Ser  Asp Ile Asp Gln Ser  Phe Asn Lys 
    2555                 2560                 2565             


Val Ala  Glu Arg Val Leu Met  Arg Leu Gln Glu Lys  Leu Lys Gly 
    2570                 2575                 2580             


Val Glu  Glu Gly Thr Val Leu  Ser Val Gly Gly Gln  Val Asn Leu 
    2585                 2590                 2595             


Leu Ile  Gln Gln Ala Ile Asp  Pro Lys Asn Leu Ser  Arg Leu Phe 
    2600                 2605                 2610             


Pro Gly  Trp Lys Ala Trp Val  
    2615                 2620 


<210>  66
<211>  2158
<212>  PRT
<213>  homo sapiens

<400>  66

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Ser Phe Leu  Phe Cys Tyr 
    2150                 2155             


<210>  67
<211>  1775
<212>  PRT
<213>  homo sapiens

<400>  67

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Val Ser  
    1775 


<210>  68
<211>  1708
<212>  PRT
<213>  homo sapiens

<400>  68

Met Thr Leu His Glu Pro Ala Asn Ser Ser Ala Ser Gln Ser Thr Asp 
1               5                   10                  15      


Leu Cys Asp Phe Ser Gly Asp Leu Asp Pro Ala Pro Asn Pro Pro His 
            20                  25                  30          


Phe Pro Ser His Val Ile Lys Ala Thr Phe Ala Tyr Ile Ser Asn Cys 
        35                  40                  45              


His Lys Thr Lys Leu Lys Ser Ile Leu Glu Ile Leu Ser Lys Ser Pro 
    50                  55                  60                  


Asp Ser Tyr Gln Lys Ile Leu Leu Ala Ile Cys Glu Gln Ala Ala Glu 
65                  70                  75                  80  


Thr Asn Asn Val Tyr Lys Lys His Arg Ile Leu Lys Ile Tyr His Leu 
                85                  90                  95      


Phe Val Ser Leu Leu Leu Lys Asp Ile Lys Ser Gly Leu Gly Gly Ala 
            100                 105                 110         


Trp Ala Phe Val Leu Arg Asp Val Ile Tyr Thr Leu Ile His Tyr Ile 
        115                 120                 125             


Asn Gln Arg Pro Ser Cys Ile Met Asp Val Ser Leu Arg Ser Phe Ser 
    130                 135                 140                 


Leu Cys Cys Asp Leu Leu Ser Gln Val Cys Gln Thr Ala Val Thr Tyr 
145                 150                 155                 160 


Cys Lys Asp Ala Leu Glu Asn His Leu His Val Ile Val Gly Thr Leu 
                165                 170                 175     


Ile Pro Leu Val Tyr Glu Gln Val Glu Val Gln Lys Gln Val Leu Asp 
            180                 185                 190         


Leu Leu Lys Tyr Leu Val Ile Asp Asn Lys Asp Asn Glu Asn Leu Tyr 
        195                 200                 205             


Ile Thr Ile Lys Leu Leu Asp Pro Phe Pro Asp His Val Val Phe Lys 
    210                 215                 220                 


Asp Leu Arg Ile Thr Gln Gln Lys Ile Lys Tyr Ser Arg Gly Pro Phe 
225                 230                 235                 240 


Ser Leu Leu Glu Glu Ile Asn His Phe Leu Ser Val Ser Val Tyr Asp 
                245                 250                 255     


Ala Leu Pro Leu Thr Arg Leu Glu Gly Leu Lys Asp Leu Arg Arg Gln 
            260                 265                 270         


Leu Glu Leu His Lys Asp Gln Met Val Asp Ile Met Arg Ala Ser Gln 
        275                 280                 285             


Asp Asn Pro Gln Asp Gly Ile Met Val Lys Leu Val Val Asn Leu Leu 
    290                 295                 300                 


Gln Leu Ser Lys Met Ala Ile Asn His Thr Gly Glu Lys Glu Val Leu 
305                 310                 315                 320 


Glu Ala Val Gly Ser Cys Leu Gly Glu Val Gly Pro Ile Asp Phe Ser 
                325                 330                 335     


Thr Ile Ala Ile Gln His Ser Lys Asp Ala Ser Tyr Thr Lys Ala Leu 
            340                 345                 350         


Lys Leu Phe Glu Asp Lys Glu Leu Gln Trp Thr Phe Ile Met Leu Thr 
        355                 360                 365             


Tyr Leu Asn Asn Thr Leu Val Glu Asp Cys Val Lys Val Arg Ser Ala 
    370                 375                 380                 


Ala Val Thr Cys Leu Lys Asn Ile Leu Ala Thr Lys Thr Gly His Ser 
385                 390                 395                 400 


Phe Trp Glu Ile Tyr Lys Met Thr Thr Asp Pro Met Leu Ala Tyr Leu 
                405                 410                 415     


Gln Pro Phe Arg Thr Ser Arg Lys Lys Phe Leu Glu Val Pro Arg Phe 
            420                 425                 430         


Asp Lys Glu Asn Pro Phe Glu Gly Leu Asp Asp Ile Asn Leu Trp Ile 
        435                 440                 445             


Pro Leu Ser Glu Asn His Asp Ile Trp Ile Lys Thr Leu Thr Cys Ala 
    450                 455                 460                 


Phe Leu Asp Ser Gly Gly Thr Lys Cys Glu Ile Leu Gln Leu Leu Lys 
465                 470                 475                 480 


Pro Met Cys Glu Val Lys Thr Asp Phe Cys Gln Thr Val Leu Pro Tyr 
                485                 490                 495     


Leu Ile His Asp Ile Leu Leu Gln Asp Thr Asn Glu Ser Trp Arg Asn 
            500                 505                 510         


Leu Leu Ser Thr His Val Gln Gly Phe Phe Thr Ser Cys Leu Arg His 
        515                 520                 525             


Phe Ser Gln Thr Ser Arg Ser Thr Thr Pro Ala Asn Leu Asp Ser Glu 
    530                 535                 540                 


Ser Glu His Phe Phe Arg Cys Cys Leu Asp Lys Lys Ser Gln Arg Thr 
545                 550                 555                 560 


Met Leu Ala Val Val Asp Tyr Met Arg Arg Gln Lys Arg Pro Ser Ser 
                565                 570                 575     


Gly Thr Ile Phe Asn Asp Ala Phe Trp Leu Asp Leu Asn Tyr Leu Glu 
            580                 585                 590         


Val Ala Lys Val Ala Gln Ser Cys Ala Ala His Phe Thr Ala Leu Leu 
        595                 600                 605             


Tyr Ala Glu Ile Tyr Ala Asp Lys Lys Ser Met Asp Asp Gln Glu Lys 
    610                 615                 620                 


Arg Ser Leu Ala Phe Glu Glu Gly Ser Gln Ser Thr Thr Ile Ser Ser 
625                 630                 635                 640 


Leu Ser Glu Lys Ser Lys Glu Glu Thr Gly Ile Ser Leu Gln Asp Leu 
                645                 650                 655     


Leu Leu Glu Ile Tyr Arg Ser Ile Gly Glu Pro Asp Ser Leu Tyr Gly 
            660                 665                 670         


Cys Gly Gly Gly Lys Met Leu Gln Pro Ile Thr Arg Leu Arg Thr Tyr 
        675                 680                 685             


Glu His Glu Ala Met Trp Gly Lys Ala Leu Val Thr Tyr Asp Leu Glu 
    690                 695                 700                 


Thr Ala Ile Pro Ser Ser Thr Arg Gln Ala Gly Ile Ile Gln Ala Leu 
705                 710                 715                 720 


Gln Asn Leu Gly Leu Cys His Ile Leu Ser Val Tyr Leu Lys Gly Leu 
                725                 730                 735     


Asp Tyr Glu Asn Lys Asp Trp Cys Pro Glu Leu Glu Glu Leu His Tyr 
            740                 745                 750         


Gln Ala Ala Trp Arg Asn Met Gln Trp Asp His Cys Thr Ser Val Ser 
        755                 760                 765             


Lys Glu Val Glu Gly Thr Ser Tyr His Glu Ser Leu Tyr Asn Ala Leu 
    770                 775                 780                 


Gln Ser Leu Arg Asp Arg Glu Phe Ser Thr Phe Tyr Glu Ser Leu Lys 
785                 790                 795                 800 


Tyr Ala Arg Val Lys Glu Val Glu Glu Met Cys Lys Arg Ser Leu Glu 
                805                 810                 815     


Ser Val Tyr Ser Leu Tyr Pro Thr Leu Ser Arg Leu Gln Ala Ile Gly 
            820                 825                 830         


Glu Leu Glu Ser Ile Gly Glu Leu Phe Ser Arg Ser Val Thr His Arg 
        835                 840                 845             


Gln Leu Ser Glu Val Tyr Ile Lys Trp Gln Lys His Ser Gln Leu Leu 
    850                 855                 860                 


Lys Asp Ser Asp Phe Ser Phe Gln Glu Pro Ile Met Ala Leu Arg Thr 
865                 870                 875                 880 


Val Ile Leu Glu Ile Leu Met Glu Lys Glu Met Asp Asn Ser Gln Arg 
                885                 890                 895     


Glu Cys Ile Lys Asp Ile Leu Thr Lys His Leu Val Glu Leu Ser Ile 
            900                 905                 910         


Leu Ala Arg Thr Phe Lys Asn Thr Gln Leu Pro Glu Arg Ala Ile Phe 
        915                 920                 925             


Gln Ile Lys Gln Tyr Asn Ser Val Ser Cys Gly Val Ser Glu Trp Gln 
    930                 935                 940                 


Leu Glu Glu Ala Gln Val Phe Trp Ala Lys Lys Glu Gln Ser Leu Ala 
945                 950                 955                 960 


Leu Ser Ile Leu Lys Gln Met Ile Lys Lys Leu Asp Ala Ser Cys Ala 
                965                 970                 975     


Ala Asn Asn Pro Ser Leu Lys Leu Thr Tyr Thr Glu Cys Leu Arg Val 
            980                 985                 990         


Cys Gly Asn Trp Leu Ala Glu Thr  Cys Leu Glu Asn Pro  Ala Val Ile 
        995                 1000                 1005             


Met Gln  Thr Tyr Leu Glu Lys  Ala Val Glu Val Ala  Gly Asn Tyr 
    1010                 1015                 1020             


Asp Gly  Glu Ser Ser Asp Glu  Leu Arg Asn Gly Lys  Met Lys Ala 
    1025                 1030                 1035             


Phe Leu  Ser Leu Ala Arg Phe  Ser Asp Thr Gln Tyr  Gln Arg Ile 
    1040                 1045                 1050             


Glu Asn  Tyr Met Lys Ser Ser  Glu Phe Glu Asn Lys  Gln Ala Leu 
    1055                 1060                 1065             


Leu Lys  Arg Ala Lys Glu Glu  Val Gly Leu Leu Arg  Glu His Lys 
    1070                 1075                 1080             


Ile Gln  Thr Asn Arg Tyr Thr  Val Lys Val Gln Arg  Glu Leu Glu 
    1085                 1090                 1095             


Leu Asp  Glu Leu Ala Leu Arg  Ala Leu Lys Glu Asp  Arg Lys Arg 
    1100                 1105                 1110             


Phe Leu  Cys Lys Ala Val Glu  Asn Tyr Ile Asn Cys  Leu Leu Ser 
    1115                 1120                 1125             


Gly Glu  Glu His Asp Met Trp  Val Phe Arg Leu Cys  Ser Leu Trp 
    1130                 1135                 1140             


Leu Glu  Asn Ser Gly Val Ser  Glu Val Asn Gly Met  Met Lys Arg 
    1145                 1150                 1155             


Asp Gly  Met Lys Ile Pro Thr  Tyr Lys Phe Leu Pro  Leu Met Tyr 
    1160                 1165                 1170             


Gln Leu  Ala Ala Arg Met Gly  Thr Lys Met Met Gly  Gly Leu Gly 
    1175                 1180                 1185             


Phe His  Glu Val Leu Asn Asn  Leu Ile Ser Arg Ile  Ser Met Asp 
    1190                 1195                 1200             


His Pro  His His Thr Leu Phe  Ile Ile Leu Ala Leu  Ala Asn Ala 
    1205                 1210                 1215             


Asn Arg  Asp Glu Phe Leu Thr  Lys Pro Glu Val Ala  Arg Arg Ser 
    1220                 1225                 1230             


Arg Ile  Thr Lys Asn Val Pro  Lys Gln Ser Ser Gln  Leu Asp Glu 
    1235                 1240                 1245             


Asp Arg  Thr Glu Ala Ala Asn  Arg Ile Ile Cys Thr  Ile Arg Ser 
    1250                 1255                 1260             


Arg Arg  Pro Gln Met Val Arg  Ser Val Glu Ala Leu  Cys Asp Ala 
    1265                 1270                 1275             


Tyr Ile  Ile Leu Ala Asn Leu  Asp Ala Thr Gln Trp  Lys Thr Gln 
    1280                 1285                 1290             


Arg Lys  Gly Ile Asn Ile Pro  Ala Asp Gln Pro Ile  Thr Lys Leu 
    1295                 1300                 1305             


Lys Asn  Leu Glu Asp Val Val  Val Pro Thr Met Glu  Ile Lys Val 
    1310                 1315                 1320             


Asp His  Thr Gly Glu Tyr Gly  Asn Leu Val Thr Ile  Gln Ser Phe 
    1325                 1330                 1335             


Lys Ala  Glu Phe Arg Leu Ala  Gly Gly Val Asn Leu  Pro Lys Ile 
    1340                 1345                 1350             


Ile Asp  Cys Val Gly Ser Asp  Gly Lys Glu Arg Arg  Gln Leu Val 
    1355                 1360                 1365             


Lys Gly  Arg Asp Asp Leu Arg  Gln Asp Ala Val Met  Gln Gln Val 
    1370                 1375                 1380             


Phe Gln  Met Cys Asn Thr Leu  Leu Gln Arg Asn Thr  Glu Thr Arg 
    1385                 1390                 1395             


Lys Arg  Lys Leu Thr Ile Cys  Thr Tyr Lys Val Val  Pro Leu Ser 
    1400                 1405                 1410             


Gln Arg  Ser Gly Val Leu Glu  Trp Cys Thr Gly Thr  Val Pro Ile 
    1415                 1420                 1425             


Gly Glu  Phe Leu Val Asn Asn  Glu Asp Gly Ala His  Lys Arg Tyr 
    1430                 1435                 1440             


Arg Pro  Asn Asp Phe Ser Ala  Phe Gln Cys Gln Lys  Lys Met Met 
    1445                 1450                 1455             


Glu Val  Gln Lys Lys Ser Phe  Glu Glu Lys Tyr Glu  Val Phe Met 
    1460                 1465                 1470             


Asp Val  Cys Gln Asn Phe Gln  Pro Val Phe Arg Tyr  Phe Cys Met 
    1475                 1480                 1485             


Glu Lys  Phe Leu Asp Pro Ala  Ile Trp Phe Glu Lys  Arg Leu Ala 
    1490                 1495                 1500             


Tyr Thr  Arg Ser Val Ala Thr  Ser Ser Ile Val Gly  Tyr Ile Leu 
    1505                 1510                 1515             


Gly Leu  Gly Asp Arg His Val  Gln Asn Ile Leu Ile  Asn Glu Gln 
    1520                 1525                 1530             


Ser Ala  Glu Leu Val His Ile  Asp Leu Gly Val Ala  Phe Glu Gln 
    1535                 1540                 1545             


Gly Lys  Ile Leu Pro Thr Pro  Glu Thr Val Pro Phe  Arg Leu Thr 
    1550                 1555                 1560             


Arg Asp  Ile Val Asp Gly Met  Gly Ile Thr Gly Val  Glu Gly Val 
    1565                 1570                 1575             


Phe Arg  Arg Cys Cys Glu Lys  Thr Met Glu Val Met  Arg Asn Ser 
    1580                 1585                 1590             


Gln Glu  Thr Leu Leu Thr Ile  Val Glu Val Leu Leu  Tyr Asp Pro 
    1595                 1600                 1605             


Leu Phe  Asp Trp Thr Met Asn  Pro Leu Lys Ala Leu  Tyr Leu Gln 
    1610                 1615                 1620             


Gln Arg  Pro Glu Asp Glu Thr  Glu Leu His Pro Thr  Leu Asn Ala 
    1625                 1630                 1635             


Asp Asp  Gln Glu Cys Lys Arg  Asn Leu Ser Asp Ile  Asp Gln Ser 
    1640                 1645                 1650             


Phe Asn  Lys Val Ala Glu Arg  Val Leu Met Arg Leu  Gln Glu Lys 
    1655                 1660                 1665             


Leu Lys  Gly Val Glu Glu Gly  Thr Val Leu Ser Val  Gly Gly Gln 
    1670                 1675                 1680             


Val Asn  Leu Leu Ile Gln Gln  Ala Ile Asp Pro Lys  Asn Leu Ser 
    1685                 1690                 1695             


Arg Leu  Phe Pro Gly Trp Lys  Ala Trp Val 
    1700                 1705             


<210>  69
<211>  380
<212>  PRT
<213>  homo sapiens

<400>  69

Met Gly Ile Gln Gly Leu Ala Lys Leu Ile Ala Asp Val Ala Pro Ser 
1               5                   10                  15      


Ala Ile Arg Glu Asn Asp Ile Lys Ser Tyr Phe Gly Arg Lys Val Ala 
            20                  25                  30          


Ile Asp Ala Ser Met Ser Ile Tyr Gln Phe Leu Ile Ala Val Arg Gln 
        35                  40                  45              


Gly Gly Asp Val Leu Gln Asn Glu Glu Gly Glu Thr Thr Ser His Leu 
    50                  55                  60                  


Met Gly Met Phe Tyr Arg Thr Ile Arg Met Met Glu Asn Gly Ile Lys 
65                  70                  75                  80  


Pro Val Tyr Val Phe Asp Gly Lys Pro Pro Gln Leu Lys Ser Gly Glu 
                85                  90                  95      


Leu Ala Lys Arg Ser Glu Arg Arg Ala Glu Ala Glu Lys Gln Leu Gln 
            100                 105                 110         


Gln Ala Gln Ala Ala Gly Ala Glu Gln Glu Val Glu Lys Phe Thr Lys 
        115                 120                 125             


Arg Leu Val Lys Val Thr Lys Gln His Asn Asp Glu Cys Lys His Leu 
    130                 135                 140                 


Leu Ser Leu Met Gly Ile Pro Tyr Leu Asp Ala Pro Ser Glu Ala Glu 
145                 150                 155                 160 


Ala Ser Cys Ala Ala Leu Val Lys Ala Gly Lys Val Tyr Ala Ala Ala 
                165                 170                 175     


Thr Glu Asp Met Asp Cys Leu Thr Phe Gly Ser Pro Val Leu Met Arg 
            180                 185                 190         


His Leu Thr Ala Ser Glu Ala Lys Lys Leu Pro Ile Gln Glu Phe His 
        195                 200                 205             


Leu Ser Arg Ile Leu Gln Glu Leu Gly Leu Asn Gln Glu Gln Phe Val 
    210                 215                 220                 


Asp Leu Cys Ile Leu Leu Gly Ser Asp Tyr Cys Glu Ser Ile Arg Gly 
225                 230                 235                 240 


Ile Gly Pro Lys Arg Ala Val Asp Leu Ile Gln Lys His Lys Ser Ile 
                245                 250                 255     


Glu Glu Ile Val Arg Arg Leu Asp Pro Asn Lys Tyr Pro Val Pro Glu 
            260                 265                 270         


Asn Trp Leu His Lys Glu Ala His Gln Leu Phe Leu Glu Pro Glu Val 
        275                 280                 285             


Leu Asp Pro Glu Ser Val Glu Leu Lys Trp Ser Glu Pro Asn Glu Glu 
    290                 295                 300                 


Glu Leu Ile Lys Phe Met Cys Gly Glu Lys Gln Phe Ser Glu Glu Arg 
305                 310                 315                 320 


Ile Arg Ser Gly Val Lys Arg Leu Ser Lys Ser Arg Gln Gly Ser Thr 
                325                 330                 335     


Gln Gly Arg Leu Asp Asp Phe Phe Lys Val Thr Gly Ser Leu Ser Ser 
            340                 345                 350         


Ala Lys Arg Lys Glu Pro Glu Pro Lys Gly Ser Thr Lys Lys Lys Ala 
        355                 360                 365             


Lys Thr Gly Ala Ala Gly Lys Phe Lys Arg Gly Lys 
    370                 375                 380 


<210>  70
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MMEJ deletion - ASXL1 c.1900_1922del23 p.E635fs*15 ds DNA before 
       deletion

<400>  70
ggcgagaggt caccactgcc atagagaggc ggccaccact gccatcggag ggggg            55


<210>  71
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MMEJ deletion- ASXL1 c.1900_1922del23 p.E635fs*15 ds DNA after 
       deletion

<400>  71
ggcgagaggt caccactgcc atcggagggg gg                                     32


<210>  72
<211>  79
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MMEJ deletion- CALR c.1092_1143del52 p.L367fs*46 before deletion

<400>  72
aggacgagga gcagaggctt aaggaggagg aagaagacaa gaaacgcaaa gaggaggagg       60

aggcagagga caaggagga                                                    79


<210>  73
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MMEJ deletion- CALR c.1092_1143del52 p.L367fs*46 after deletion

<400>  73
aggacgagga gcagaggaca aggagga                                           27


<210>  74
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MMEJ deletion- SRSF2 c.284_307del24 p.P95_R102del before deletion

<400>  74
ggcggtcccc ggcggctgtg gtgtgagtcc ggggggcggc cgtagcgcgc                  50


<210>  75
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  MMEJ deletion- SRSF2 c.284_307del24 p.P95_R102del after deletion

<400>  75
ggcggtcccc ggcggccgta gcgcgc                                            26


<210>  76
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  76
ctgcaggtcc gaggggcgag                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  77
cagtggtggc cgcctctcta                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  78
aggtcaccac tgccatagag                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  79
tggccgcctc tctatggcag                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  80
tcaccactgc catagagagg                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  81
cccccctccg atggcagtgg                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  82
cggccaccac tgccatcgga                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  83
gactcacacc acagccgccg                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  84
cggactcaca ccacagccgc                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  85
gcggctgtgg tgtgagtccg                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  86
cggctgtggt gtgagtccgg                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  87
ggctgtggtg tgagtccggg                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  88
cggcggctgt ggtgtgagtc                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  89
cgggtgcaaa tggcgcgcta                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  90
acaaacagga cgaggagcag                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  91
ggacgaggag cagaggctta                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  92
cgaggagcag aggcttaagg                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  93
agaagacaag aaacgcaaag                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  94
agacaagaaa cgcaaagagg                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  95
gaaacgcaaa gaggaggagg                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  96
ggaggaggag gcagaggaca                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  sgRNA sequence

<400>  97
ggaggaggca gaggacaagg                                                   20


<210>  98
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  98
actatcatat gcttaccgta ac                                                22


<210>  99
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  99
ctacacgacg ctcttccgat ctaccctcgc agacattaaa gc                          42


<210>  100
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  100
cagacgtgtg ctcttccgat ctgtagatct gacgtacact ttcca                       45


<210>  101
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  101
ctacacgacg ctcttccgat ctctcagccc cgtttacctg                             40


<210>  102
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  102
cagacgtgtg ctcttccgat ctctgaggac gctatggatg                             40


<210>  103
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  103
ctacacgacg ctcttccgat ctgcagcaga gaaacaaatg aa                          42


<210>  104
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  104
cagacgtgtg ctcttccgat ctggacatct tcctcctcat ct                          42


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  105
tgcggggtgg cggtccccgg                                                   20


