                         SEQUENCE LISTING

<110>  Universitt Heidelberg
 
<120>  Artificial Antigen Presenting Molecules and Their Uses

<130>  6024/P/1010-WO

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Pro Arg Gly Pro Thr Ile Lys Pro Ser Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


<210>  2
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  3
<211>  217
<212>  PRT
<213>  Mus musculus

<400>  3

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val Leu Thr Ala Gln Thr Gln Thr His Arg Glu 
    50                  55                  60                  


Asp Tyr Gln Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            100                 105                 110         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        115                 120                 125             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    130                 135                 140                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
145                 150                 155                 160 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                165                 170                 175     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            180                 185                 190         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        195                 200                 205             


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    210                 215         


<210>  4
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein purifcation tag

<400>  5

Asp Pro Gly His His His His His His Ser Ser 
1               5                   10      


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein purification tag

<400>  6

Asp Pro Gly Trp Ser His Pro Gln Phe Glu Lys Ser Ser 
1               5                   10              


<210>  7
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially designed peptide spacer sequence

<400>  7

Asp Pro Gly Trp Ser His Pro Gln Phe Glu Lys Ser Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Ser Trp Ser 
            20                  25                  30          


His Pro Gln Phe Glu Lys Ser Ser 
        35                  40  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein purification tag with C-terminal cysteine residue

<400>  8

Asp Pro Gly Trp Ser His Pro Gln Phe Glu Lys Arg Ser Cys 
1               5                   10                  


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein purification tag

<400>  9

Asp Pro Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
1               5                   10                  15      


Glu Val 
        


<210>  10
<211>  9
<212>  PRT
<213>  Human cytomegalovirus

<400>  10

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Leu Leu Met Trp Ile Thr Gln Val 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Met Leu Gly Glu Phe Leu Lys Leu 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Human herpesvirus 4

<400>  13

Gly Leu Cys Thr Leu Val Ala Met Leu 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Influenza A virus

<400>  14

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus

<400>  15

Ser Leu Tyr Asn Thr Val Ala Thr Leu 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Human papillomavirus type 16

<400>  16

Tyr Met Leu Asp Leu Gln Pro Glu Thr 
1               5                   


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Ile Leu Ala Lys Phe Leu His Trp Leu 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Tyr Leu Ser Gly Ala Asn Leu Asn Leu 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Leu Leu Gly Arg Asn Ser Phe Glu Val 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Leu Ser Lys Ile Leu Asp Thr Val 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Thr Ala Pro Pro Val His Asn Val 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Tyr Val Asp Pro Val Ile Thr Ser Ile 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Leu Val Val Val Gly Ala Gly Gly Val 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  26

Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  27

Lys Leu Val Val Val Gly Ala Asp Gly Val 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  28

Lys Leu Val Val Val Gly Ala Gly Asp Val 
1               5                   10  


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially designed linker sequence

<400>  30

Gly Cys Gly Ser Gly Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  31
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asp Tyr 
        115                 120                 125             


Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala 
    130                 135                 140                 


Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln 
145                 150                 155                 160 


Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr 
                165                 170                 175     


Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr 
            180                 185                 190         


His Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys 
        195                 200                 205             


Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
    210                 215                 220                 


Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
225                 230                 235                 240 


Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
                245                 250                 255     


Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
            260                 265                 270         


Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro 
        275                 280                 285             


<210>  32
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asn Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Glu Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Glu Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro 
        275                 280             


<210>  33
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein sequence designed for combination with antigen 
       pepetide sequence to function as aAPM

<400>  33

Gly Cys Gly Ser Gly Gly Gly Gly Ala Pro Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
            20                  25                  30          


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
        35                  40                  45              


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
    50                  55                  60                  


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
65                  70                  75                  80  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
                85                  90                  95      


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
            100                 105                 110         


Arg Asp Met Arg Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ala Ser Gly Gly Gly Gly Gly Ser His Ser 
    130                 135                 140                 


Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro 
145                 150                 155                 160 


Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe 
                165                 170                 175     


Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile 
            180                 185                 190         


Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys 
        195                 200                 205             


Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Cys 
    210                 215                 220                 


Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly 
225                 230                 235                 240 


Cys Asn Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr 
                245                 250                 255     


Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser 
            260                 265                 270         


Trp Thr Ala Ala Glu Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu 
        275                 280                 285             


Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys 
    290                 295                 300                 


Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln 
305                 310                 315                 320 


Arg Thr Asp Ala Pro Lys Thr His Met Thr His His Ala Val Ser Asp 
                325                 330                 335     


His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu 
            340                 345                 350         


Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr 
        355                 360                 365             


Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp 
    370                 375                 380                 


Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His 
385                 390                 395                 400 


Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro 
                405                 410                 415     


Ser Ser Gln Pro Thr Ile Pro Thr Ser Gln Leu Thr Ser Glu Pro Arg 
            420                 425                 430         


Gly Pro Thr Ile Lys Pro Ser Pro Pro Cys Lys Cys Pro Ala Pro Asn 
        435                 440                 445             


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
    450                 455                 460                 


Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val Val Asp 
465                 470                 475                 480 


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
                485                 490                 495     


Val Glu Val Leu Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Gln 
            500                 505                 510         


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
        515                 520                 525             


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro 
    530                 535                 540                 


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
545                 550                 555                 560 


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
                565                 570                 575     


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
            580                 585                 590         


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
        595                 600                 605             


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
    610                 615                 620                 


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
625                 630                 635                 640 


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
                645                 650                 655     


Ser Arg Thr Pro Gly Lys Asp Pro Gly Trp Ser His Pro Gln Phe Glu 
            660                 665                 670         


Lys Ser Ser 
        675 


<210>  34
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  34

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  35
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificially designed linker sequence

<400>  35

Arg Ser Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Ala Ser Gly Gly Gly Gly 
            20                  25  


<210>  36
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asn Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Glu Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Ser Ser Gln Pro Thr Ile Pro 
        275                 280             


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially designed linker sequence

<400>  37

Thr Ser Gln Leu Thr Ser 
1               5       


<210>  38
<211>  233
<212>  PRT
<213>  Mus musculus

<400>  38

Glu Pro Arg Gly Pro Thr Ile Lys Pro Ser Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val Leu Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Gln Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             


<210>  39
<211>  18
<212>  PRT
<213>  Influenza A virus

<400>  39

Met Ala Lys Ala Asn Leu Leu Val Leu Leu Cys Ala Leu Ala Ala Ala 
1               5                   10                  15      


Asp Ala 
        


<210>  40
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  41
<211>  13
<212>  PRT
<213>  Human cytomegalovirus

<400>  41

Tyr Gln Glu Phe Phe Trp Asp Ala Asn Asp Ile Tyr Arg 
1               5                   10              


<210>  42
<211>  13
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  42

Met Ala Lys Thr Ile Ala Tyr Asp Glu Glu Ala Arg Arg 
1               5                   10              


<210>  43
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  43

Asp Asn Lys Ser Lys Ile Thr Ile Asp Ile His Phe Leu Glu Arg Lys 
1               5                   10                  15      


Met Gln His His 
            20  


<210>  44
<211>  13
<212>  PRT
<213>  Influenza A virus

<400>  44

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10              


<210>  45
<211>  12
<212>  PRT
<213>  Clostridium tetani

<400>  45

Gly Gln Ile Gly Asn Asp Pro Asn Arg Asp Ile Leu 
1               5                   10          


<210>  46
<211>  13
<212>  PRT
<213>  Human herpesvirus 4

<400>  46

Lys Glu Leu Lys Arg Gln Tyr Glu Lys Lys Leu Arg Gln 
1               5                   10              


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially designed protein linker

<400>  47

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly 
        


<210>  48
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  48

Pro Val Ser Lys Met Arg Met Ala Thr Pro Leu Leu Met Gln Ala 
1               5                   10                  15  


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially designed peptide linker sequence

<400>  49

Gly Ser Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Ser Gly Ser 
1               5                   10                  15      


<210>  50
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Asp Thr Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His 
            20                  25                  30          


Asn Gln Glu Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Leu Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His 
                85                  90                  95      


Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  51
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  51

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Asn 
            180                 185                 190         


<210>  52
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala 
            20                  25  


<210>  53
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  53

Lys Gln Leu Lys Lys Lys Leu Gln Ala Leu Lys Lys Lys Asn Ala Gln 
1               5                   10                  15      


Leu Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln 
            20                  25                  30  


<210>  54
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  54

Lys Gln Leu Glu Lys Glu Leu Gln Ala Leu Glu Lys Glu Asn Ala Gln 
1               5                   10                  15      


Leu Glu Trp Glu Leu Gln Ala Leu Glu Lys Glu Leu Ala Gln 
            20                  25                  30  


<210>  55
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially designed fusion protein

<400>  55

Gly Asp Thr Arg Pro Arg Phe Leu Glu Tyr Ser Thr Ser Glu Cys His 
1               5                   10                  15      


Phe Phe Asn Gly Thr Glu Arg Val Arg Tyr Leu Asp Arg Tyr Phe His 
            20                  25                  30          


Asn Gln Glu Glu Asn Val Arg Phe Asp Ser Asp Val Gly Glu Phe Arg 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Leu Leu Glu Gln Lys Arg Gly Arg Val Asp Asn Tyr Cys Arg 
65                  70                  75                  80  


His Asn Tyr Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val His 
                85                  90                  95      


Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Ser Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Gly Gln Glu Glu Lys Thr Gly Val Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile His Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Val Thr Ser Pro Leu Thr Val Glu Trp Arg Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys Asn Ser Gly Gly Gly Gly Ser Lys Gln Leu 
        195                 200                 205             


Lys Lys Lys Leu Gln Ala Leu Lys Lys Lys Asn Ala Gln Leu Lys Trp 
    210                 215                 220                 


Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln Ala Ser Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Ser Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val Leu Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Gln 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Lys Asp Pro Gly Leu Asn Asp Ile Phe Glu Ala 
465                 470                 475                 480 


Gln Lys Ile Glu Trp His Glu His His His His His His 
                485                 490             


<210>  56
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificially designed fusion protein

<400>  56

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Asn 
            180                 185                 190         


Ser Gly Gly Gly Gly Ser Lys Gln Leu Glu Lys Glu Leu Gln Ala Leu 
        195                 200                 205             


Glu Lys Glu Asn Ala Gln Leu Glu Trp Glu Leu Gln Ala Leu Glu Lys 
    210                 215                 220                 


Glu Leu Ala Gln Ala Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Ser 
225                 230                 235                 240 


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
            260                 265                 270         


Pro Met Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
        275                 280                 285             


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val Leu Thr Ala Gln 
    290                 295                 300                 


Thr Gln Thr His Arg Glu Asp Tyr Gln Ser Thr Leu Arg Val Val Ser 
305                 310                 315                 320 


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
                325                 330                 335     


Cys Lys Val Asn Asn Lys Ala Leu Pro Ala Pro Ile Glu Arg Thr Ile 
            340                 345                 350         


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
        355                 360                 365             


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
    370                 375                 380                 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
385                 390                 395                 400 


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
            420                 425                 430         


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
        435                 440                 445             


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Asp 
    450                 455                 460                 


Pro Gly Trp Ser His Pro Gln Phe Glu Lys Ser Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Ser Trp Ser His 
                485                 490                 495     


Pro Gln Phe Glu Lys Ser Ser 
            500             


<210>  57
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially designed nucleotide sequence encoding fusion 
       protein/aAPM

<400>  57
atggccaagg ccaacctgct cgtgctgctc tgcgccctgg cggccgctga cgccaacctg       60

gtgcccatgg tggccaccgt gggctgcgga tccggaggag gcggcgcgcc ggggtctgga      120

ggtggatcca tccagcgtac tccaaagatt caggtttact cacgtcatcc agcagagaat      180

ggaaagtcaa atttcctgaa ttgctatgtg tctgggtttc atccatccga cattgaagtt      240

gacttactga agaatggaga gagaattgaa aaagtggagc attcagactt gtctttcagc      300

aaggactggt ctttctatct cttgtactac actgaattca cccccactga aaaagatgag      360

tatgcctgcc gtgtgaacca tgtgactttg tcacagccca agatagttaa gtgggatcga      420

gacatgagat cggctagtgg tggtggtggt tctggtggtg gtggttctgg tggtggtggt      480

tctgctagcg gcggaggcgg ctcccactcc atgaggtatt tcttcacatc cgtgtcccgg      540

cccggccgcg gggagccccg cttcatcgca gtgggctacg tggacgacac gcagttcgtg      600

cggttcgaca gcgacgccgc gagccagagg atggagccgc gggcgccgtg gatagagcag      660

gagggtccag agtattggga cggggagaca cggaaagtga aggcccactc acagactcac      720

cgagtggacc tggggaccct gcgcggctgt tataaccaga gcgaggccgg ttctcacacc      780

gtccagagga tgtatggctg cgacgtgggg tcggactggc gcttcctccg cgggtaccac      840

cagtacgcct acgacggcaa ggattacatc gccctgaaag aggacctgcg ctcttggacc      900

gcggcggaca tggcagctca gaccaccaag cacaagtggg aggcggccca tgtggcggag      960

cagttgagag cctacctgga gggcacgtgc gtggagtggc tccgcagata cctggagaac     1020

gggaaggaga cgctgcagcg cacggacgcc cccaaaacgc atatgactca ccacgctgtc     1080

tctgaccatg aagccaccct gaggtgctgg gccctgagct tctaccctgc ggagatcaca     1140

ctgacctggc agcgggatgg ggaggaccag acccaggaca cggagctcgt ggagaccagg     1200

cctgcagggg atggaacctt ccagaagtgg gcggctgtgg tggtgccttc tggacaggag     1260

cagagataca cctgccatgt gcagcatgag ggtttgccca agcccctcac cctgagatgg     1320

gagccgtctt cccagcccac catccccact agccaattga ctagtgagcc cagaggaccc     1380

acaatcaagc cctctcctcc atgcaaatgc ccagcaccta acctcttggg tggaccatcc     1440

gtcttcatct tccctccaaa gatcaaggat gtactcatga tctccctgag ccccatggtc     1500

acatgtgtgg tggtggatgt gagcgaggat gacccagatg tccagatcag ctggttcgtg     1560

aacaacgtgg aagtactcac agctcagaca caaacccata gagaggatta ccagagtact     1620

ctccgggtgg tcagtgccct ccccatccag caccaggact ggatgagtgg caaggagttc     1680

aaatgcaagg tcaacaacaa agccctccca gcgcccatcg agagaaccat ctcaaaaccc     1740

aaagggtcag taagagctcc acaggtatat gtcttgcctc caccagaaga agagatgact     1800

aagaaacagg tcactctgac ctgcatggtc acagacttca tgcctgaaga catttacgtg     1860

gagtggacca acaacgggaa aacagagcta aactacaaga acactgaacc agtcctggac     1920

tctgatggtt cttacttcat gtacagcaag ctgagagtgg aaaagaagaa ctgggtggaa     1980

agaaatagct actcctgctc agtggtccac gagggtctgc acaatcacca cacgactaag     2040

agcttctccc ggactccggg taaggatccc gggtggagcc accctcagtt cgagaagtct     2100

agagggcccg tttaa                                                      2115


<210>  58
<211>  3273
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially designed nucleotide sequence encoding fusion 
       protein/aAPM

<400>  58
atgaagtggg tgaccttcat cagcctgctg ttcctgttct cgagcgctta ctccatggct       60

aagacaatcg cttacgatga ggaagccaga cggggttccg gaggaggcgg gagcggaggc      120

ggagggagtg gaggcggcgg atccggcggg gacaccagac cacgtttctt ggagtactct      180

acgtctgagt gtcatttctt caatgggacg gagcgggtgc ggtacctgga cagatacttc      240

cataaccagg aggagaacgt gcgcttcgac agcgacgtgg gggagttccg ggcggtgacg      300

gagctggggc ggcctgatgc cgagtactgg aacagccaga aggacctcct ggagcagaag      360

cggggccggg tggacaacta ctgcagacac aactacgggg ttgtggagag cttcacagtg      420

cagcggcgag tccatcctaa ggtgactgtg tatccttcaa agacccagcc cctgcagcac      480

cataacctcc tggtctgttc tgtgagtggt ttctatccag gcagcattga agtcaggtgg      540

ttccggaatg gccaggaaga gaagactggg gtggtgtcca caggcctgat ccacaatgga      600

gactggacct tccagaccct ggtgatgctg gaaacagttc ctcggagtgg agaggtttac      660

acctgccaag tggagcaccc aagcgtgaca agccctctca cagtggaatg gagagcacgg      720

tctgaatctg cacagagcaa gaattccggc ggaggcggat ccaagcagct gaagaaaaag      780

ctccaggccc tgaagaagaa aaacgcccag ctcaagtgga agctccaggc cctgaaaaag      840

aagctggccc aggctagcga gcccagaggg cccacaatca agccctctcc tccatgcaaa      900

tgcccagcac ctaacctctt gggtggacca tccgtcttca tcttccctcc aaagatcaag      960

gatgtactca tgatctccct gagccccatg gtcacatgtg tggtggtgga tgtgagcgag     1020

gatgacccag atgtccagat cagctggttc gtgaacaacg tggaagtact cacagctcag     1080

acacaaaccc atagagagga ttaccagagt actctccggg tggtcagtgc cctccccatc     1140

cagcaccagg actggatgag tggcaaggag ttcaaatgca aggtcaacaa caaagccctc     1200

ccagcgccca tcgagagaac catctcaaaa cccaaagggt cagtaagagc tccacaggta     1260

tatgtcttgc ctccaccaga agaagagatg actaagaaac aggtcactct gacctgcatg     1320

gtcacagact tcatgcctga agacatttac gtggagtgga ccaacaacgg gaaaacagag     1380

ctaaactaca agaacactga accagtcctg gactctgatg gttcttactt catgtacagc     1440

aagctgagag tggaaaagaa gaactgggtg gaaagaaata gctactcctg ctcagtggtc     1500

cacgagggtc tgcacaatca ccacacgact aagagcttct cccggactcc gggtaaggat     1560

cccgggctga acgacatctt cgaggctcag aaaatcgaat ggcacgagca ccatcaccat     1620

caccatggct ccggcgaggg cagaggaagc ttgctgacat gtggcgacgt ggaagagaac     1680

cctggcccta tggccataag tggagtccct gtgctaggat ttttcatcat agctgtgctg     1740

atgagcgctc aggaatcatg ggctatcaaa gaagaacatg tgatcatcca ggccgagttc     1800

tatctgaatc ctgaccaatc aggcgagttt atgtttgact ttgatggtga tgagattttc     1860

catgtggata tggcaaagaa ggagacggtc tggcggcttg aagaatttgg acgatttgcc     1920

agctttgagg ctcaaggtgc attggccaac atagctgtgg acaaagccaa cctggaaatc     1980

atgacaaagc gctccaacta tactccgatc accaatgtac ctccagaggt aactgtgctc     2040

acgaacagcc ctgtggaact gagagagccc aacgtcctca tctgtttcat cgacaagttc     2100

accccaccag tggtcaatgt cacgtggctt cgaaatggaa aacctgtcac cacaggagtg     2160

tcagagacag tcttcctgcc cagggaagac caccttttcc gcaagttcca ctatctcccc     2220

ttcctgccct caactgagga cgtttacgac tgcagggtgg agcactgggg cttggatgag     2280

cctcttctca agcactggga gtttgatgct ccaagccctc tcccagagac tacagagaat     2340

tccggcggag gcggatccaa gcagctcgaa aaggagctgc aagccctgga gaaggagaac     2400

gcccagctgg aatgggaact ccaggccctg gagaaagagc tggcccaggc tagcgagccc     2460

agagggccca caatcaagcc ctctcctcca tgcaaatgcc cagcacctaa cctcttgggt     2520

ggaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc     2580

cccatggtca catgtgtggt ggtggatgtg agcgaggatg acccagatgt ccagatcagc     2640

tggttcgtga acaacgtgga agtactcaca gctcagacac aaacccatag agaggattac     2700

cagagtactc tccgggtggt cagtgccctc cccatccagc accaggactg gatgagtggc     2760

aaggagttca aatgcaaggt caacaacaaa gccctcccag cgcccatcga gagaaccatc     2820

tcaaaaccca aagggtcagt aagagctcca caggtatatg tcttgcctcc accagaagaa     2880

gagatgacta agaaacaggt cactctgacc tgcatggtca cagacttcat gcctgaagac     2940

atttacgtgg agtggaccaa caacgggaaa acagagctaa actacaagaa cactgaacca     3000

gtcctggact ctgatggttc ttacttcatg tacagcaagc tgagagtgga aaagaagaac     3060

tgggtggaaa gaaatagcta ctcctgctca gtggtccacg agggtctgca caatcaccac     3120

acgactaaga gcttctcccg gactccgggt aaggatcccg ggtggagcca ccctcagttc     3180

gagaagtcta gtggcggagg aggctccgga ggcggaggca gcggcggagg aggcggatct     3240

agttggagcc accctcagtt cgagaaggtc tag                                  3273


