                         SEQUENCE LISTING

<110>  ҽҩϺ޹˾
 
<120>  PD-L1Ϸ

<130>  IEC196121PCT

<150>  CN201911044297.0
<151>  2019-10-30

<150>  CN202010765530.0
<151>  2020-07-31

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  1

Arg Thr Asp Ser Asn Ile Asn Gly Met His 
1               5                   10  


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  2

Thr Ile Phe Ile Asp Gly Asn Thr Ile 
1               5                   


<210>  3
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  3

Asp Val Ser Gly Tyr Gly Arg Ala 
1               5               


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  4

Arg Thr Asp Ser Asn Ile His Gly Met His 
1               5                   10  


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  5

Thr Ile Phe Ile Asp Leu Asn Thr Ile 
1               5                   


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  6

Arg Thr Asp Ser Asn Ile Phe Gly Met His 
1               5                   10  


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  7

Thr Ile Phe Ile Asp Ala Asn Thr Ile 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  8

Thr Ile Phe Ile Asp Gly Asn Thr Leu 
1               5                   


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  9

Asp Val Ser Gly Tyr Gly Arg Tyr 
1               5               


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  10

Arg Thr Asp Ser Asn Ile Asn Ser Met His 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  11

Thr Trp Phe Ile Asp Gly Asn Thr Ile 
1               5                   


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  12

Asp Glu Trp Met Tyr Gly Arg Ala 
1               5               


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  13

Arg Thr Asp Arg Asn Ile Asn Thr Met His 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  14

Arg Thr Tyr Ser Asn Ile Tyr Gly Met His 
1               5                   10  


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  15

Thr Ile Phe Ile Gly Ser Asn Thr Ile 
1               5                   


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  16

Arg Thr Gly Ser Asn Ile Tyr Gly Met His 
1               5                   10  


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  17

Thr Ile Phe Ile Asp Trp Asn Thr Ile 
1               5                   


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  18

Arg Thr Phe Ser Asn Ile Phe Gly Met His 
1               5                   10  


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  19

Thr Ile Phe Ile Thr Gly Asn Thr Ile 
1               5                   


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  20

Arg Thr Leu Ser Asn Ile Arg Gly Met His 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  21

Arg Arg Trp Ser Asn Ile His Gly Met His 
1               5                   10  


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  22

Ser Arg Phe Ile Thr Gly Asn Thr Ile 
1               5                   


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  23

Asp Val Arg Gly Tyr Gly Arg Ala 
1               5               


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  24

Pro Thr Ala Ser Asn Ile His Gly Met His 
1               5                   10  


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  25

Met Ile Phe Ile Thr Gly Leu Thr Ile 
1               5                   


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  26

Arg Thr Ala Ser Asn Ala Met Gly Met His 
1               5                   10  


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  27

Met Ile Phe Arg Asp Gly Asn Thr Ile 
1               5                   


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  28

Arg Thr Ala Gly Asn Ile His Gly Met His 
1               5                   10  


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  29

Ser Ile Phe Ile Thr Gly Asn Thr Ile 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  30

Arg Thr Ala Gly Tyr Ile His Gly Met His 
1               5                   10  


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  31

Met Ile Phe Gly Trp Gly Asn Thr Ile 
1               5                   


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  32

Gly Phe Thr Phe Ser Arg Arg Cys Lys Ala 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  33

Lys Ile Leu Thr Thr Ser Gly Ser Thr Tyr 
1               5                   10  


<210>  34
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  34

Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser Gly Ala 
1               5                   10                  15      


Phe Gln Tyr 
            


<210>  35
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  35

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Arg 
            20                  25                  30          


Cys Lys Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ala Lys Ile Leu Thr Thr Ser Gly Ser Thr Tyr Leu Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Ser Phe Glu Asp Pro Thr Cys Thr Leu Val Thr Ser Ser 
            100                 105                 110         


Gly Ala Phe Gln Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  36
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  36

Glu Val Gln Val Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Arg Thr Asp Ser Asn Ile Asn 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Asp Gly Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  37
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Asp Ser Asn Ile Asn 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Asp Gly Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  38
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Arg Thr Asp Ser Asn Ile Asn 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Asp Gly Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  39
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Arg Thr Asp Ser Asn Ile His 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Asp Leu Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  40
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Arg Thr Asp Ser Asn Ile Phe 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Asp Ala Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  41
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Arg Thr Asp Ser Asn Ile Asn 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Asp Gly Asn Thr Leu Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  42
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Arg Thr Asp Ser Asn Ile Asn 
            20                  25                  30          


Ser Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Trp Phe Ile Asp Gly Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Glu Trp Met Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  43
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Asp Arg Asn Ile Asn 
            20                  25                  30          


Thr Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Asp Leu Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  44
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Tyr Ser Asn Ile Tyr 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Gly Ser Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  45
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Gly Ser Asn Ile Tyr 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Asp Trp Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  46
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Phe Ser Asn Ile Phe 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Thr Gly Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  47
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Leu Ser Asn Ile Arg 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Thr Ile Phe Ile Asp Leu Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  48
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Arg Trp Ser Asn Ile His 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Ser Arg Phe Ile Thr Gly Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Arg Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  49
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Pro Thr Ala Ser Asn Ile His 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Met Ile Phe Ile Thr Gly Leu Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Ser Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  50
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  50

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Ala Ser Asn Ala Met 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Met Ile Phe Arg Asp Gly Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Arg Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  51
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Ala Gly Asn Ile His 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Phe Ile Thr Gly Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Arg Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  52
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Thr Ala Gly Tyr Ile His 
            20                  25                  30          


Gly Met His Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Gly Met Ile Phe Gly Trp Gly Asn Thr Ile Val Thr Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Asp Val Arg Gly Tyr Gly Arg Ala Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  53
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  53

Glu Val Gln Val Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser 
            20                  25  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  54

Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Asp Trp Val Gly 
1               5                   10                  


<210>  55
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  55

Val Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Phe Cys Ala Ala 
        35                  


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  56

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  57
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  58

Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val Gly 
1               5                   10                  


<210>  59
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  59

Val Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
1               5                   10                  15      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  60

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  61
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser 
            20                  25  


<210>  62
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  63
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  63

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ala 
1               5                   10                  


<210>  64
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  64

Leu Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
1               5                   10                  15      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys Ala Ala 
        35                  


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  65

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


