                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF BRITISH COLUMBIA
       WITHERS, Stephen G.
       WAKARCHUK, Warren W.
       SIM, Lyann
 
<120>  COMPOSITIONS AND METHODS FOR SIALYLATED MUCIN-TYPE 
       O-GLYCOSYLATION OF THERAPEUTIC PROTEINS

<130>  P1696PC00

<150>  62/929,733
<151>  2019-11-01

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Leu Gly Ile 
    370                 375                 380                 


Glu Gly Arg Ile Ser Glu Phe Gly Ser Lys Lys Lys Asp Leu His His 
385                 390                 395                 400 


Ser Asn Gly Glu Glu Lys Ala Gln Ser Met Glu Thr Leu Pro Pro Gly 
                405                 410                 415     


Lys Val Arg Trp Pro Asp Phe Asn Gln Glu Ala Tyr Val Gly Gly Thr 
            420                 425                 430         


Met Val Arg Ser Gly Gln Asp Pro Tyr Ala Arg Asn Lys Phe Asn Gln 
        435                 440                 445             


Val Glu Ser Asp Lys Leu Arg Met Asp Arg Ala Ile Pro Asp Thr Arg 
    450                 455                 460                 


His Asp Gln Cys Gln Arg Lys Gln Trp Arg Val Asp Leu Pro Ala Thr 
465                 470                 475                 480 


Ser Val Val Ile Thr Phe His Asn Glu Ala Arg Ser Ala Leu Leu Arg 
                485                 490                 495     


Thr Val Val Ser Val Leu Lys Lys Ser Pro Pro His Leu Ile Lys Glu 
            500                 505                 510         


Ile Ile Leu Val Asp Asp Tyr Ser Asn Asp Pro Glu Asp Gly Ala Leu 
        515                 520                 525             


Leu Gly Lys Ile Glu Lys Val Arg Val Leu Arg Asn Asp Arg Arg Glu 
    530                 535                 540                 


Gly Leu Met Arg Ser Arg Val Arg Gly Ala Asp Ala Ala Gln Ala Lys 
545                 550                 555                 560 


Val Leu Thr Phe Leu Asp Ser His Cys Glu Cys Asn Glu His Trp Leu 
                565                 570                 575     


Glu Pro Leu Leu Glu Arg Val Ala Glu Asp Arg Thr Arg Val Val Ser 
            580                 585                 590         


Pro Ile Ile Asp Val Ile Asn Met Asp Asn Phe Gln Tyr Val Gly Ala 
        595                 600                 605             


Ser Ala Asp Leu Lys Gly Gly Phe Asp Trp Asn Leu Val Phe Lys Trp 
    610                 615                 620                 


Asp Tyr Met Thr Pro Glu Gln Arg Arg Ser Arg Gln Gly Asn Pro Val 
625                 630                 635                 640 


Ala Pro Ile Lys Thr Pro Met Ile Ala Gly Gly Leu Phe Val Met Asp 
                645                 650                 655     


Lys Phe Tyr Phe Glu Glu Leu Gly Lys Tyr Asp Met Met Met Asp Val 
            660                 665                 670         


Trp Gly Gly Glu Asn Leu Glu Ile Ser Phe Arg Val Trp Gln Cys Gly 
        675                 680                 685             


Gly Ser Leu Glu Ile Ile Pro Cys Ser Arg Val Gly His Val Phe Arg 
    690                 695                 700                 


Lys Gln His Pro Tyr Thr Phe Pro Gly Gly Ser Gly Thr Val Phe Ala 
705                 710                 715                 720 


Arg Asn Thr Arg Arg Ala Ala Glu Val Trp Met Asp Glu Tyr Lys Asn 
                725                 730                 735     


Phe Tyr Tyr Ala Ala Val Pro Ser Ala Arg Asn Val Pro Tyr Gly Asn 
            740                 745                 750         


Ile Gln Ser Arg Leu Glu Leu Arg Lys Lys Leu Ser Cys Lys Pro Phe 
        755                 760                 765             


Lys Trp Tyr Leu Glu Asn Val Tyr Pro Glu Leu Arg Val Pro Asp His 
    770                 775                 780                 


Gln Asp Ile Ala Phe Gly Ala Leu Gln Gln Gly Thr Asn Cys Leu Asp 
785                 790                 795                 800 


Thr Leu Gly His Phe Ala Asp Gly Val Val Gly Val Tyr Glu Cys His 
                805                 810                 815     


Asn Ala Gly Gly Asn Gln Glu Trp Ala Leu Thr Lys Glu Lys Ser Val 
            820                 825                 830         


Lys His Met Asp Leu Cys Leu Thr Val Val Asp Arg Ala Pro Gly Ser 
        835                 840                 845             


Leu Ile Lys Leu Gln Gly Cys Arg Glu Asn Asp Ser Arg Gln Lys Trp 
    850                 855                 860                 


Glu Gln Ile Glu Gly Asn Ser Lys Leu Arg His Val Gly Ser Asn Leu 
865                 870                 875                 880 


Cys Leu Asp Ser Arg Thr Ala Lys Ser Gly Gly Leu Ser Val Glu Val 
                885                 890                 895     


Cys Gly Pro Ala Leu Ser Gln Gln Trp Lys Phe Thr Leu Asn Leu Gln 
            900                 905                 910         


Gln 
    


<210>  2
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Arg Arg Ser Arg Met Leu Leu Cys Phe Ala Phe Leu Trp Val 
1               5                   10                  15      


Leu Gly Ile Ala Tyr Tyr Met Tyr Ser Gly Gly Gly Ser Ala Leu Ala 
            20                  25                  30          


Gly Gly Ala Gly Gly Gly Ala Gly Arg Lys Glu Asp Trp Asn Glu Ile 
        35                  40                  45              


Asp Pro Ile Lys Lys Lys Asp Leu His His Ser Asn Gly Glu Glu Lys 
    50                  55                  60                  


Ala Gln Ser Met Glu Thr Leu Pro Pro Gly Lys Val Arg Trp Pro Asp 
65                  70                  75                  80  


Phe Asn Gln Glu Ala Tyr Val Gly Gly Thr Met Val Arg Ser Gly Gln 
                85                  90                  95      


Asp Pro Tyr Ala Arg Asn Lys Phe Asn Gln Val Glu Ser Asp Lys Leu 
            100                 105                 110         


Arg Met Asp Arg Ala Ile Pro Asp Thr Arg His Asp Gln Cys Gln Arg 
        115                 120                 125             


Lys Gln Trp Arg Val Asp Leu Pro Ala Thr Ser Val Val Ile Thr Phe 
    130                 135                 140                 


His Asn Glu Ala Arg Ser Ala Leu Leu Arg Thr Val Val Ser Val Leu 
145                 150                 155                 160 


Lys Lys Ser Pro Pro His Leu Ile Lys Glu Ile Ile Leu Val Asp Asp 
                165                 170                 175     


Tyr Ser Asn Asp Pro Glu Asp Gly Ala Leu Leu Gly Lys Ile Glu Lys 
            180                 185                 190         


Val Arg Val Leu Arg Asn Asp Arg Arg Glu Gly Leu Met Arg Ser Arg 
        195                 200                 205             


Val Arg Gly Ala Asp Ala Ala Gln Ala Lys Val Leu Thr Phe Leu Asp 
    210                 215                 220                 


Ser His Cys Glu Cys Asn Glu His Trp Leu Glu Pro Leu Leu Glu Arg 
225                 230                 235                 240 


Val Ala Glu Asp Arg Thr Arg Val Val Ser Pro Ile Ile Asp Val Ile 
                245                 250                 255     


Asn Met Asp Asn Phe Gln Tyr Val Gly Ala Ser Ala Asp Leu Lys Gly 
            260                 265                 270         


Gly Phe Asp Trp Asn Leu Val Phe Lys Trp Asp Tyr Met Thr Pro Glu 
        275                 280                 285             


Gln Arg Arg Ser Arg Gln Gly Asn Pro Val Ala Pro Ile Lys Thr Pro 
    290                 295                 300                 


Met Ile Ala Gly Gly Leu Phe Val Met Asp Lys Phe Tyr Phe Glu Glu 
305                 310                 315                 320 


Leu Gly Lys Tyr Asp Met Met Met Asp Val Trp Gly Gly Glu Asn Leu 
                325                 330                 335     


Glu Ile Ser Phe Arg Val Trp Gln Cys Gly Gly Ser Leu Glu Ile Ile 
            340                 345                 350         


Pro Cys Ser Arg Val Gly His Val Phe Arg Lys Gln His Pro Tyr Thr 
        355                 360                 365             


Phe Pro Gly Gly Ser Gly Thr Val Phe Ala Arg Asn Thr Arg Arg Ala 
    370                 375                 380                 


Ala Glu Val Trp Met Asp Glu Tyr Lys Asn Phe Tyr Tyr Ala Ala Val 
385                 390                 395                 400 


Pro Ser Ala Arg Asn Val Pro Tyr Gly Asn Ile Gln Ser Arg Leu Glu 
                405                 410                 415     


Leu Arg Lys Lys Leu Ser Cys Lys Pro Phe Lys Trp Tyr Leu Glu Asn 
            420                 425                 430         


Val Tyr Pro Glu Leu Arg Val Pro Asp His Gln Asp Ile Ala Phe Gly 
        435                 440                 445             


Ala Leu Gln Gln Gly Thr Asn Cys Leu Asp Thr Leu Gly His Phe Ala 
    450                 455                 460                 


Asp Gly Val Val Gly Val Tyr Glu Cys His Asn Ala Gly Gly Asn Gln 
465                 470                 475                 480 


Glu Trp Ala Leu Thr Lys Glu Lys Ser Val Lys His Met Asp Leu Cys 
                485                 490                 495     


Leu Thr Val Val Asp Arg Ala Pro Gly Ser Leu Ile Lys Leu Gln Gly 
            500                 505                 510         


Cys Arg Glu Asn Asp Ser Arg Gln Lys Trp Glu Gln Ile Glu Gly Asn 
        515                 520                 525             


Ser Lys Leu Arg His Val Gly Ser Asn Leu Cys Leu Asp Ser Arg Thr 
    530                 535                 540                 


Ala Lys Ser Gly Gly Leu Ser Val Glu Val Cys Gly Pro Ala Leu Ser 
545                 550                 555                 560 


Gln Gln Trp Lys Phe Thr Leu Asn Leu Gln Gln 
                565                 570     


<210>  3
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Lys Phe Ala Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Ile 
1               5                   10                  15      


Trp Val Leu Leu Asp Met Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Glu Lys Lys Glu Arg Gly Leu Pro Ala Gly Asp Val Leu 
        35                  40                  45              


Glu Pro Val Gln Lys Pro His Glu Gly Pro Gly Glu Met Gly Lys Pro 
    50                  55                  60                  


Val Val Ile Pro Lys Glu Asp Gln Glu Lys Met Lys Glu Met Phe Lys 
65                  70                  75                  80  


Ile Asn Gln Phe Asn Leu Met Ala Ser Glu Met Ile Ala Leu Asn Arg 
                85                  90                  95      


Ser Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro 
            100                 105                 110         


Asp Asn Leu Pro Thr Thr Ser Val Val Ile Val Phe His Asn Glu Ala 
        115                 120                 125             


Trp Ser Thr Leu Leu Arg Thr Val His Ser Val Ile Asn Arg Ser Pro 
    130                 135                 140                 


Arg His Met Ile Glu Glu Ile Val Leu Val Asp Asp Ala Ser Glu Arg 
145                 150                 155                 160 


Asp Phe Leu Lys Arg Pro Leu Glu Ser Tyr Val Lys Lys Leu Lys Val 
                165                 170                 175     


Pro Val His Val Ile Arg Met Glu Gln Arg Ser Gly Leu Ile Arg Ala 
            180                 185                 190         


Arg Leu Lys Gly Ala Ala Val Ser Lys Gly Gln Val Ile Thr Phe Leu 
        195                 200                 205             


Asp Ala His Cys Glu Cys Thr Val Gly Trp Leu Glu Pro Leu Leu Ala 
    210                 215                 220                 


Arg Ile Lys His Asp Arg Arg Thr Val Val Cys Pro Ile Ile Asp Val 
225                 230                 235                 240 


Ile Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr 
                245                 250                 255     


Gly Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr 
        275                 280                 285             


Pro Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asp Tyr Phe Gln 
    290                 295                 300                 


Glu Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn 
305                 310                 315                 320 


Leu Glu Ile Ser Phe Arg Ile Trp Gln Cys Gly Gly Thr Leu Glu Ile 
                325                 330                 335     


Val Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr 
            340                 345                 350         


Thr Phe Pro Gly Gly Thr Gly Gln Ile Ile Asn Lys Asn Asn Arg Arg 
        355                 360                 365             


Leu Ala Glu Val Trp Met Asp Glu Phe Lys Asn Phe Phe Tyr Ile Ile 
    370                 375                 380                 


Ser Pro Gly Val Thr Lys Val Asp Tyr Gly Asp Ile Ser Ser Arg Val 
385                 390                 395                 400 


Gly Leu Arg His Lys Leu Gln Cys Lys Pro Phe Ser Trp Tyr Leu Glu 
                405                 410                 415     


Asn Ile Tyr Pro Asp Ser Gln Ile Pro Arg His Tyr Phe Ser Leu Gly 
            420                 425                 430         


Glu Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Ala Arg 
        435                 440                 445             


Lys Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly 
    450                 455                 460                 


Asn Gln Val Phe Ser Tyr Thr Ala Asn Lys Glu Ile Arg Thr Asp Asp 
465                 470                 475                 480 


Leu Cys Leu Asp Val Ser Lys Leu Asn Gly Pro Val Thr Met Leu Lys 
                485                 490                 495     


Cys His His Leu Lys Gly Asn Gln Leu Trp Glu Tyr Asp Pro Val Lys 
            500                 505                 510         


Leu Thr Leu Gln His Val Asn Ser Asn Gln Cys Leu Asp Lys Ala Thr 
        515                 520                 525             


Glu Glu Asp Ser Gln Val Pro Ser Ile Arg Asp Cys Asn Gly Ser Arg 
    530                 535                 540                 


Ser Gln Gln Trp Leu Leu Arg Asn Val Thr Leu Pro Glu Ile Phe 
545                 550                 555                 


<210>  4
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala His Leu Lys Arg Leu Val Lys Leu His Ile Lys Arg His Tyr 
1               5                   10                  15      


His Lys Lys Phe Trp Lys Leu Gly Ala Val Ile Phe Phe Phe Ile Ile 
            20                  25                  30          


Val Leu Val Leu Met Gln Arg Glu Val Ser Val Gln Tyr Ser Lys Glu 
        35                  40                  45              


Glu Ser Arg Met Glu Arg Asn Met Lys Asn Lys Asn Lys Met Leu Asp 
    50                  55                  60                  


Leu Met Leu Glu Ala Val Asn Asn Ile Lys Asp Ala Met Pro Lys Met 
65                  70                  75                  80  


Gln Ile Gly Ala Pro Val Arg Gln Asn Ile Asp Ala Gly Glu Arg Pro 
                85                  90                  95      


Cys Leu Gln Gly Tyr Tyr Thr Ala Ala Glu Leu Lys Pro Val Leu Asp 
            100                 105                 110         


Arg Pro Pro Gln Asp Ser Asn Ala Pro Gly Ala Ser Gly Lys Ala Phe 
        115                 120                 125             


Lys Thr Thr Asn Leu Ser Val Glu Glu Gln Lys Glu Lys Glu Arg Gly 
    130                 135                 140                 


Glu Ala Lys His Cys Phe Asn Ala Phe Ala Ser Asp Arg Ile Ser Leu 
145                 150                 155                 160 


His Arg Asp Leu Gly Pro Asp Thr Arg Pro Pro Glu Cys Ile Glu Gln 
                165                 170                 175     


Lys Phe Lys Arg Cys Pro Pro Leu Pro Thr Thr Ser Val Ile Ile Val 
            180                 185                 190         


Phe His Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val His Ser Val 
        195                 200                 205             


Leu Tyr Ser Ser Pro Ala Ile Leu Leu Lys Glu Ile Ile Leu Val Asp 
    210                 215                 220                 


Asp Ala Ser Val Asp Glu Tyr Leu His Asp Lys Leu Asp Glu Tyr Val 
225                 230                 235                 240 


Lys Gln Phe Ser Ile Val Lys Ile Val Arg Gln Arg Glu Arg Lys Gly 
                245                 250                 255     


Leu Ile Thr Ala Arg Leu Leu Gly Ala Thr Val Ala Thr Ala Glu Thr 
            260                 265                 270         


Leu Thr Phe Leu Asp Ala His Cys Glu Cys Phe Tyr Gly Trp Leu Glu 
        275                 280                 285             


Pro Leu Leu Ala Arg Ile Ala Glu Asn Tyr Thr Ala Val Val Ser Pro 
    290                 295                 300                 


Asp Ile Ala Ser Ile Asp Leu Asn Thr Phe Glu Phe Asn Lys Pro Ser 
305                 310                 315                 320 


Pro Tyr Gly Ser Asn His Asn Arg Gly Asn Phe Asp Trp Ser Leu Ser 
                325                 330                 335     


Phe Gly Trp Glu Ser Leu Pro Asp His Glu Lys Gln Arg Arg Lys Asp 
            340                 345                 350         


Glu Thr Tyr Pro Ile Lys Thr Pro Thr Phe Ala Gly Gly Leu Phe Ser 
        355                 360                 365             


Ile Ser Lys Glu Tyr Phe Glu Tyr Ile Gly Ser Tyr Asp Glu Glu Met 
    370                 375                 380                 


Glu Ile Trp Gly Gly Glu Asn Ile Glu Met Ser Phe Arg Val Trp Gln 
385                 390                 395                 400 


Cys Gly Gly Gln Leu Glu Ile Met Pro Cys Ser Val Val Gly His Val 
                405                 410                 415     


Phe Arg Ser Lys Ser Pro His Ser Phe Pro Lys Gly Thr Gln Val Ile 
            420                 425                 430         


Ala Arg Asn Gln Val Arg Leu Ala Glu Val Trp Met Asp Glu Tyr Lys 
        435                 440                 445             


Glu Ile Phe Tyr Arg Arg Asn Thr Asp Ala Ala Lys Ile Val Lys Gln 
    450                 455                 460                 


Lys Ala Phe Gly Asp Leu Ser Lys Arg Phe Glu Ile Lys His Arg Leu 
465                 470                 475                 480 


Gln Cys Lys Asn Phe Thr Trp Tyr Leu Asn Asn Ile Tyr Pro Glu Val 
                485                 490                 495     


Tyr Val Pro Asp Leu Asn Pro Val Ile Ser Gly Tyr Ile Lys Ser Val 
            500                 505                 510         


Gly Gln Pro Leu Cys Leu Asp Val Gly Glu Asn Asn Gln Gly Gly Lys 
        515                 520                 525             


Pro Leu Ile Met Tyr Thr Cys His Gly Leu Gly Gly Asn Gln Tyr Phe 
    530                 535                 540                 


Glu Tyr Ser Ala Gln His Glu Ile Arg His Asn Ile Gln Lys Glu Leu 
545                 550                 555                 560 


Cys Leu His Ala Ala Gln Gly Leu Val Gln Leu Lys Ala Cys Thr Tyr 
                565                 570                 575     


Lys Gly His Lys Thr Val Val Thr Gly Glu Gln Ile Trp Glu Ile Gln 
            580                 585                 590         


Lys Asp Gln Leu Leu Tyr Asn Pro Phe Leu Lys Met Cys Leu Ser Ala 
        595                 600                 605             


Asn Gly Glu His Pro Ser Leu Val Ser Cys Asn Pro Ser Asp Pro Leu 
    610                 615                 620                 


Gln Lys Trp Ile Leu Ser Gln Asn Asp 
625                 630             


<210>  5
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Val Arg Trp Thr Trp Ala Gly Lys Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Phe Leu Thr Val Ala Tyr Ile Phe Val Glu Leu Leu Val Ser Thr Phe 
            20                  25                  30          


His Ala Ser Ala Gly Ala Gly Arg Ala Arg Glu Leu Gly Ser Arg Arg 
        35                  40                  45              


Leu Ser Asp Leu Gln Lys Asn Thr Glu Asp Leu Ser Arg Pro Leu Tyr 
    50                  55                  60                  


Lys Lys Pro Pro Ala Asp Ser Arg Ala Leu Gly Glu Trp Gly Lys Ala 
65                  70                  75                  80  


Ser Lys Leu Gln Leu Asn Glu Asp Glu Leu Lys Gln Gln Glu Glu Leu 
                85                  90                  95      


Ile Glu Arg Tyr Ala Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser Leu 
            100                 105                 110         


His Arg His Ile Glu Asp Lys Arg Met Tyr Glu Cys Lys Ser Gln Lys 
        115                 120                 125             


Phe Asn Tyr Arg Thr Leu Pro Thr Thr Ser Val Ile Ile Ala Phe Tyr 
    130                 135                 140                 


Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Ile His Ser Val Leu Glu 
145                 150                 155                 160 


Thr Ser Pro Ala Val Leu Leu Lys Glu Ile Ile Leu Val Asp Asp Leu 
                165                 170                 175     


Ser Asp Arg Val Tyr Leu Lys Thr Gln Leu Glu Thr Tyr Ile Ser Asn 
            180                 185                 190         


Leu Asp Arg Val Arg Leu Ile Arg Thr Asn Lys Arg Glu Gly Leu Val 
        195                 200                 205             


Arg Ala Arg Leu Ile Gly Ala Thr Phe Ala Thr Gly Asp Val Leu Thr 
    210                 215                 220                 


Phe Leu Asp Cys His Cys Glu Cys Asn Ser Gly Trp Leu Glu Pro Leu 
225                 230                 235                 240 


Leu Glu Arg Ile Gly Arg Asp Glu Thr Ala Val Val Cys Pro Val Ile 
                245                 250                 255     


Asp Thr Ile Asp Trp Asn Thr Phe Glu Phe Tyr Met Gln Ile Gly Glu 
            260                 265                 270         


Pro Met Ile Gly Gly Phe Asp Trp Arg Leu Thr Phe Gln Trp His Ser 
        275                 280                 285             


Val Pro Lys Gln Glu Arg Asp Arg Arg Ile Ser Arg Ile Asp Pro Ile 
    290                 295                 300                 


Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys Tyr 
305                 310                 315                 320 


Phe Gln Tyr Leu Gly Thr Tyr Asp Thr Gly Met Glu Val Trp Gly Gly 
                325                 330                 335     


Glu Asn Leu Glu Leu Ser Phe Arg Val Trp Gln Cys Gly Gly Lys Leu 
            340                 345                 350         


Glu Ile His Pro Cys Ser His Val Gly His Val Phe Pro Lys Arg Ala 
        355                 360                 365             


Pro Tyr Ala Arg Pro Asn Phe Leu Gln Asn Thr Ala Arg Ala Ala Glu 
    370                 375                 380                 


Val Trp Met Asp Glu Tyr Lys Glu His Phe Tyr Asn Arg Asn Pro Pro 
385                 390                 395                 400 


Ala Arg Lys Glu Ala Tyr Gly Asp Ile Ser Glu Arg Lys Leu Leu Arg 
                405                 410                 415     


Glu Arg Leu Arg Cys Lys Ser Phe Asp Trp Tyr Leu Lys Asn Val Phe 
            420                 425                 430         


Pro Asn Leu His Val Pro Glu Asp Arg Pro Gly Trp His Gly Ala Ile 
        435                 440                 445             


Arg Ser Arg Gly Ile Ser Ser Glu Cys Leu Asp Tyr Asn Ser Pro Asp 
    450                 455                 460                 


Asn Asn Pro Thr Gly Ala Asn Leu Ser Leu Phe Gly Cys His Gly Gln 
465                 470                 475                 480 


Gly Gly Asn Gln Phe Phe Glu Tyr Thr Ser Asn Lys Glu Ile Arg Phe 
                485                 490                 495     


Asn Ser Val Thr Glu Leu Cys Ala Glu Val Pro Glu Gln Lys Asn Tyr 
            500                 505                 510         


Val Gly Met Gln Asn Cys Pro Lys Asp Gly Phe Pro Val Pro Ala Asn 
        515                 520                 525             


Ile Ile Trp His Phe Lys Glu Asp Gly Thr Ile Phe His Pro His Ser 
    530                 535                 540                 


Gly Leu Cys Leu Ser Ala Tyr Arg Thr Pro Glu Gly Arg Pro Asp Val 
545                 550                 555                 560 


Gln Met Arg Thr Cys Asp Ala Leu Asp Lys Asn Gln Ile Trp Ser Phe 
                565                 570                 575     


Glu Lys 
        


<210>  6
<211>  940
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Arg Ile Arg Lys Phe Phe Arg Gly Ser Gly Arg Val Leu Ala 
1               5                   10                  15      


Phe Ile Phe Val Ala Ser Val Ile Trp Leu Leu Phe Asp Met Ala Ala 
            20                  25                  30          


Leu Arg Leu Ser Phe Ser Glu Ile Asn Thr Arg Val Ile Lys Glu Asp 
        35                  40                  45              


Ile Val Arg Arg Glu Arg Ile Gly Phe Arg Val Gln Pro Asp Gln Gly 
    50                  55                  60                  


Lys Ile Phe Tyr Ser Ser Ile Lys Glu Met Lys Pro Pro Leu Arg Gly 
65                  70                  75                  80  


His Gly Lys Gly Ala Trp Gly Lys Glu Asn Val Arg Lys Thr Glu Glu 
                85                  90                  95      


Ser Val Leu Lys Val Glu Val Asp Leu Asp Gln Thr Gln Arg Glu Arg 
            100                 105                 110         


Lys Met Gln Asn Ala Leu Gly Arg Gly Lys Val Val Pro Leu Trp His 
        115                 120                 125             


Pro Ala His Leu Gln Thr Leu Pro Val Thr Pro Asn Lys Gln Lys Thr 
    130                 135                 140                 


Asp Gly Arg Gly Thr Lys Pro Glu Ala Ser Ser His Gln Gly Thr Pro 
145                 150                 155                 160 


Lys Gln Thr Thr Ala Gln Gly Ala Pro Lys Thr Ser Phe Ile Ala Ala 
                165                 170                 175     


Lys Gly Thr Gln Val Val Lys Ile Ser Val His Met Gly Arg Val Ser 
            180                 185                 190         


Leu Lys Gln Glu Pro Arg Lys Ser His Ser Pro Ser Ser Asp Thr Ser 
        195                 200                 205             


Lys Leu Ala Ala Glu Arg Asp Leu Asn Val Thr Ile Ser Leu Ser Thr 
    210                 215                 220                 


Asp Arg Pro Lys Gln Arg Ser Gln Ala Val Ala Asn Glu Arg Ala His 
225                 230                 235                 240 


Pro Ala Ser Thr Ala Val Pro Lys Ser Gly Glu Ala Met Ala Leu Asn 
                245                 250                 255     


Lys Thr Lys Thr Gln Ser Lys Glu Val Asn Ala Asn Lys His Lys Ala 
            260                 265                 270         


Asn Thr Ser Leu Pro Phe Pro Lys Phe Thr Val Asn Ser Asn Arg Leu 
        275                 280                 285             


Arg Lys Gln Ser Ile Asn Glu Thr Pro Leu Gly Ser Leu Ser Lys Asp 
    290                 295                 300                 


Asp Gly Ala Arg Gly Ala His Gly Lys Lys Leu Asn Phe Ser Glu Ser 
305                 310                 315                 320 


His Leu Val Ile Ile Thr Lys Glu Glu Glu Gln Lys Ala Asp Pro Lys 
                325                 330                 335     


Glu Val Ser Asn Ser Lys Thr Lys Thr Ile Phe Pro Lys Val Leu Gly 
            340                 345                 350         


Lys Ser Gln Ser Lys His Ile Ser Arg Asn Arg Ser Glu Met Ser Ser 
        355                 360                 365             


Ser Ser Leu Ala Pro His Arg Val Pro Leu Ser Gln Thr Asn His Ala 
    370                 375                 380                 


Leu Thr Gly Gly Leu Glu Pro Ala Lys Ile Asn Ile Thr Ala Lys Ala 
385                 390                 395                 400 


Pro Ser Thr Glu Tyr Asn Gln Ser His Ile Lys Ala Leu Leu Pro Glu 
                405                 410                 415     


Asp Ser Gly Thr His Gln Val Leu Arg Ile Asp Val Thr Leu Ser Pro 
            420                 425                 430         


Arg Asp Pro Lys Ala Pro Gly Gln Phe Gly Arg Pro Val Val Val Pro 
        435                 440                 445             


His Gly Lys Glu Lys Glu Ala Glu Arg Arg Trp Lys Glu Gly Asn Phe 
    450                 455                 460                 


Asn Val Tyr Leu Ser Asp Leu Ile Pro Val Asp Arg Ala Ile Glu Asp 
465                 470                 475                 480 


Thr Arg Pro Ala Gly Cys Ala Glu Gln Leu Val His Asn Asn Leu Pro 
                485                 490                 495     


Thr Thr Ser Val Ile Met Cys Phe Val Asp Glu Val Trp Ser Thr Leu 
            500                 505                 510         


Leu Arg Ser Val His Ser Val Ile Asn Arg Ser Pro Pro His Leu Ile 
        515                 520                 525             


Lys Glu Ile Leu Leu Val Asp Asp Phe Ser Thr Lys Asp Tyr Leu Lys 
    530                 535                 540                 


Asp Asn Leu Asp Lys Tyr Met Ser Gln Phe Pro Lys Val Arg Ile Leu 
545                 550                 555                 560 


Arg Leu Lys Glu Arg His Gly Leu Ile Arg Ala Arg Leu Ala Gly Ala 
                565                 570                 575     


Gln Asn Ala Thr Gly Asp Val Leu Thr Phe Leu Asp Ser His Val Glu 
            580                 585                 590         


Cys Asn Val Gly Trp Leu Glu Pro Leu Leu Glu Arg Val Tyr Leu Ser 
        595                 600                 605             


Arg Lys Lys Val Ala Cys Pro Val Ile Glu Val Ile Asn Asp Lys Asp 
    610                 615                 620                 


Met Ser Tyr Met Thr Val Asp Asn Phe Gln Arg Gly Ile Phe Val Trp 
625                 630                 635                 640 


Pro Met Asn Phe Gly Trp Arg Thr Ile Pro Pro Asp Val Ile Ala Lys 
                645                 650                 655     


Asn Arg Ile Lys Glu Thr Asp Thr Ile Arg Cys Pro Val Met Ala Gly 
            660                 665                 670         


Gly Leu Phe Ser Ile Asp Lys Ser Tyr Phe Phe Glu Leu Gly Thr Tyr 
        675                 680                 685             


Asp Pro Gly Leu Asp Val Trp Gly Gly Glu Asn Met Glu Leu Ser Phe 
    690                 695                 700                 


Lys Val Trp Met Cys Gly Gly Glu Ile Glu Ile Ile Pro Cys Ser Arg 
705                 710                 715                 720 


Val Gly His Ile Phe Arg Asn Asp Asn Pro Tyr Ser Phe Pro Lys Asp 
                725                 730                 735     


Arg Met Lys Thr Val Glu Arg Asn Leu Val Arg Val Ala Glu Val Trp 
            740                 745                 750         


Leu Asp Glu Tyr Lys Glu Leu Phe Tyr Gly His Gly Asp His Leu Ile 
        755                 760                 765             


Asp Gln Gly Leu Asp Val Gly Asn Leu Thr Gln Gln Arg Glu Leu Arg 
    770                 775                 780                 


Lys Lys Leu Lys Cys Lys Ser Phe Lys Trp Tyr Leu Glu Asn Val Phe 
785                 790                 795                 800 


Pro Asp Leu Arg Ala Pro Ile Val Arg Ala Ser Gly Val Leu Ile Asn 
                805                 810                 815     


Val Ala Leu Gly Lys Cys Ile Ser Ile Glu Asn Thr Thr Val Ile Leu 
            820                 825                 830         


Glu Asp Cys Asp Gly Ser Lys Glu Leu Gln Gln Phe Asn Tyr Thr Trp 
        835                 840                 845             


Leu Arg Leu Ile Lys Cys Gly Glu Trp Cys Ile Ala Pro Ile Pro Asp 
    850                 855                 860                 


Lys Gly Ala Val Arg Leu His Pro Cys Asp Asn Arg Asn Lys Gly Leu 
865                 870                 875                 880 


Lys Trp Leu His Lys Ser Thr Ser Val Phe His Pro Glu Leu Val Asn 
                885                 890                 895     


His Ile Val Phe Glu Asn Asn Gln Gln Leu Leu Cys Leu Glu Gly Asn 
            900                 905                 910         


Phe Ser Gln Lys Ile Leu Lys Val Ala Ala Cys Asp Pro Val Lys Pro 
        915                 920                 925             


Tyr Gln Lys Trp Lys Phe Glu Lys Tyr Tyr Glu Ala 
    930                 935                 940 


<210>  7
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Leu Leu Arg Arg Arg His Met Pro Leu Arg Leu Ala Met Val 
1               5                   10                  15      


Gly Cys Ala Phe Val Leu Phe Leu Phe Leu Leu His Arg Asp Val Ser 
            20                  25                  30          


Ser Arg Glu Glu Ala Thr Glu Lys Pro Trp Leu Lys Ser Leu Val Ser 
        35                  40                  45              


Arg Lys Asp His Val Leu Asp Leu Met Leu Glu Ala Met Asn Asn Leu 
    50                  55                  60                  


Arg Asp Ser Met Pro Lys Leu Gln Ile Arg Ala Pro Glu Ala Gln Gln 
65                  70                  75                  80  


Thr Leu Phe Ser Ile Asn Gln Ser Cys Leu Pro Gly Phe Tyr Thr Pro 
                85                  90                  95      


Ala Glu Leu Lys Pro Phe Trp Glu Arg Pro Pro Gln Asp Pro Asn Ala 
            100                 105                 110         


Pro Gly Ala Asp Gly Lys Ala Phe Gln Lys Ser Lys Trp Thr Pro Leu 
        115                 120                 125             


Glu Thr Gln Glu Lys Glu Glu Gly Tyr Lys Lys His Cys Phe Asn Ala 
    130                 135                 140                 


Phe Ala Ser Asp Arg Ile Ser Leu Gln Arg Ser Leu Gly Pro Asp Thr 
145                 150                 155                 160 


Arg Pro Pro Glu Cys Val Asp Gln Lys Phe Arg Arg Cys Pro Pro Leu 
                165                 170                 175     


Ala Thr Thr Ser Val Ile Ile Val Phe His Asn Glu Ala Trp Ser Thr 
            180                 185                 190         


Leu Leu Arg Thr Val Tyr Ser Val Leu His Thr Thr Pro Ala Ile Leu 
        195                 200                 205             


Leu Lys Glu Ile Ile Leu Val Asp Asp Ala Ser Thr Glu Glu His Leu 
    210                 215                 220                 


Lys Glu Lys Leu Glu Gln Tyr Val Lys Gln Leu Gln Val Val Arg Val 
225                 230                 235                 240 


Val Arg Gln Glu Glu Arg Lys Gly Leu Ile Thr Ala Arg Leu Leu Gly 
                245                 250                 255     


Ala Ser Val Ala Gln Ala Glu Val Leu Thr Phe Leu Asp Ala His Cys 
            260                 265                 270         


Glu Cys Phe His Gly Trp Leu Glu Pro Leu Leu Ala Arg Ile Ala Glu 
        275                 280                 285             


Asp Lys Thr Val Val Val Ser Pro Asp Ile Val Thr Ile Asp Leu Asn 
    290                 295                 300                 


Thr Phe Glu Phe Ala Lys Pro Val Gln Arg Gly Arg Val His Ser Arg 
305                 310                 315                 320 


Gly Asn Phe Asp Trp Ser Leu Thr Phe Gly Trp Glu Thr Leu Pro Pro 
                325                 330                 335     


His Glu Lys Gln Arg Arg Lys Asp Glu Thr Tyr Pro Ile Lys Ser Pro 
            340                 345                 350         


Thr Phe Ala Gly Gly Leu Phe Ser Ile Ser Lys Ser Tyr Phe Glu His 
        355                 360                 365             


Ile Gly Thr Tyr Asp Asn Gln Met Glu Ile Trp Gly Gly Glu Asn Val 
    370                 375                 380                 


Glu Met Ser Phe Arg Val Trp Gln Cys Gly Gly Gln Leu Glu Ile Ile 
385                 390                 395                 400 


Pro Cys Ser Val Val Gly His Val Phe Arg Thr Lys Ser Pro His Thr 
                405                 410                 415     


Phe Pro Lys Gly Thr Ser Val Ile Ala Arg Asn Gln Val Arg Leu Ala 
            420                 425                 430         


Glu Val Trp Met Asp Ser Tyr Lys Lys Ile Phe Tyr Arg Arg Asn Leu 
        435                 440                 445             


Gln Ala Ala Lys Met Ala Gln Glu Lys Ser Phe Gly Asp Ile Ser Glu 
    450                 455                 460                 


Arg Leu Gln Leu Arg Glu Gln Leu His Cys His Asn Phe Ser Trp Tyr 
465                 470                 475                 480 


Leu His Asn Val Tyr Pro Glu Met Phe Val Pro Asp Leu Thr Pro Thr 
                485                 490                 495     


Phe Tyr Gly Ala Ile Lys Asn Leu Gly Thr Asn Gln Cys Leu Asp Val 
            500                 505                 510         


Gly Glu Asn Asn Arg Gly Gly Lys Pro Leu Ile Met Tyr Ser Cys His 
        515                 520                 525             


Gly Leu Gly Gly Asn Gln Tyr Phe Glu Tyr Thr Thr Gln Arg Asp Leu 
    530                 535                 540                 


Arg His Asn Ile Ala Lys Gln Leu Cys Leu His Val Ser Lys Gly Ala 
545                 550                 555                 560 


Leu Gly Leu Gly Ser Cys His Phe Thr Gly Lys Asn Ser Gln Val Pro 
                565                 570                 575     


Lys Asp Glu Glu Trp Glu Leu Ala Gln Asp Gln Leu Ile Arg Asn Ser 
            580                 585                 590         


Gly Ser Gly Thr Cys Leu Thr Ser Gln Asp Lys Lys Pro Ala Met Ala 
        595                 600                 605             


Pro Cys Asn Pro Ser Asp Pro His Gln Leu Trp Leu Phe Val 
    610                 615                 620         


<210>  8
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Leu Lys Ile Gly Phe Ile Leu Arg Ser Leu Leu Val Val Gly 
1               5                   10                  15      


Ser Phe Leu Gly Leu Val Val Leu Trp Ser Ser Leu Thr Pro Arg Pro 
            20                  25                  30          


Asp Asp Pro Ser Pro Leu Ser Arg Met Arg Glu Asp Arg Asp Val Asn 
        35                  40                  45              


Asp Pro Met Pro Asn Arg Gly Gly Asn Gly Leu Ala Pro Gly Glu Asp 
    50                  55                  60                  


Arg Phe Lys Pro Val Val Pro Trp Pro His Val Glu Gly Val Glu Val 
65                  70                  75                  80  


Asp Leu Glu Ser Ile Arg Arg Ile Asn Lys Ala Lys Asn Glu Gln Glu 
                85                  90                  95      


His His Ala Gly Gly Asp Ser Gln Lys Asp Ile Met Gln Arg Gln Tyr 
            100                 105                 110         


Leu Thr Phe Lys Pro Gln Thr Phe Thr Tyr His Asp Pro Val Leu Arg 
        115                 120                 125             


Pro Gly Ile Leu Gly Asn Phe Glu Pro Lys Glu Pro Glu Pro Pro Gly 
    130                 135                 140                 


Val Val Gly Gly Pro Gly Glu Lys Ala Lys Pro Leu Val Leu Gly Pro 
145                 150                 155                 160 


Glu Phe Lys Gln Ala Ile Gln Ala Ser Ile Lys Glu Phe Gly Phe Asn 
                165                 170                 175     


Met Val Ala Ser Asp Met Ile Ser Leu Asp Arg Ser Val Asn Asp Leu 
            180                 185                 190         


Arg Gln Glu Glu Cys Lys Tyr Trp His Tyr Asp Glu Asn Leu Leu Thr 
        195                 200                 205             


Ser Ser Val Val Ile Val Phe His Asn Glu Gly Trp Ser Thr Leu Met 
    210                 215                 220                 


Arg Thr Val His Ser Val Ile Lys Arg Thr Pro Arg Lys Tyr Leu Ala 
225                 230                 235                 240 


Glu Ile Val Leu Ile Asp Asp Phe Ser Asn Lys Glu His Leu Lys Glu 
                245                 250                 255     


Lys Leu Asp Glu Tyr Ile Lys Leu Trp Asn Gly Leu Val Lys Val Phe 
            260                 265                 270         


Arg Asn Glu Arg Arg Glu Gly Leu Ile Gln Ala Arg Ser Ile Gly Ala 
        275                 280                 285             


Gln Lys Ala Lys Leu Gly Gln Val Leu Ile Tyr Leu Asp Ala His Cys 
    290                 295                 300                 


Glu Val Ala Val Asn Trp Tyr Ala Pro Leu Val Ala Pro Ile Ser Lys 
305                 310                 315                 320 


Asp Arg Thr Ile Cys Thr Val Pro Leu Ile Asp Val Ile Asn Gly Asn 
                325                 330                 335     


Thr Tyr Glu Ile Ile Pro Gln Gly Gly Gly Asp Glu Asp Gly Tyr Ala 
            340                 345                 350         


Arg Gly Ala Trp Asp Trp Ser Met Leu Trp Lys Arg Val Pro Leu Thr 
        355                 360                 365             


Pro Gln Glu Lys Arg Leu Arg Lys Thr Lys Thr Glu Pro Tyr Arg Ser 
    370                 375                 380                 


Pro Ala Met Ala Gly Gly Leu Phe Ala Ile Glu Arg Glu Phe Phe Phe 
385                 390                 395                 400 


Glu Leu Gly Leu Tyr Asp Pro Gly Leu Gln Ile Trp Gly Gly Glu Asn 
                405                 410                 415     


Phe Glu Ile Ser Tyr Lys Ile Trp Gln Cys Gly Gly Lys Leu Leu Phe 
            420                 425                 430         


Val Pro Cys Ser Arg Val Gly His Ile Tyr Arg Leu Glu Gly Trp Gln 
        435                 440                 445             


Gly Asn Pro Pro Pro Ile Tyr Val Gly Ser Ser Pro Thr Leu Lys Asn 
    450                 455                 460                 


Tyr Val Arg Val Val Glu Val Trp Trp Asp Glu Tyr Lys Asp Tyr Phe 
465                 470                 475                 480 


Tyr Ala Ser Arg Pro Glu Ser Gln Ala Leu Pro Tyr Gly Asp Ile Ser 
                485                 490                 495     


Glu Leu Lys Lys Phe Arg Glu Asp His Asn Cys Lys Ser Phe Lys Trp 
            500                 505                 510         


Phe Met Glu Glu Ile Ala Tyr Asp Ile Thr Ser His Tyr Pro Leu Pro 
        515                 520                 525             


Pro Lys Asn Val Asp Trp Gly Glu Ile Arg Gly Phe Glu Thr Ala Tyr 
    530                 535                 540                 


Cys Ile Asp Ser Met Gly Lys Thr Asn Gly Gly Phe Val Glu Leu Gly 
545                 550                 555                 560 


Pro Cys His Arg Met Gly Gly Asn Gln Leu Phe Arg Ile Asn Glu Ala 
                565                 570                 575     


Asn Gln Leu Met Gln Tyr Asp Gln Cys Leu Thr Lys Gly Ala Asp Gly 
            580                 585                 590         


Ser Lys Val Met Ile Thr His Cys Asn Leu Asn Glu Phe Lys Glu Trp 
        595                 600                 605             


Gln Tyr Phe Lys Asn Leu His Arg Phe Thr His Ile Pro Ser Gly Lys 
    610                 615                 620                 


Cys Leu Asp Arg Ser Glu Val Leu His Gln Val Phe Ile Ser Asn Cys 
625                 630                 635                 640 


Asp Ser Ser Lys Thr Thr Gln Lys Trp Glu Met Asn Asn Ile His Ser 
                645                 650                 655     


Val 
    


<210>  9
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Met Phe Trp Arg Lys Leu Pro Lys Ala Leu Phe Ile Gly Leu Thr 
1               5                   10                  15      


Leu Ala Ile Ala Val Asn Leu Leu Leu Val Phe Ser Ser Lys Gly Thr 
            20                  25                  30          


Leu Gln Asn Leu Phe Thr Gly Gly Leu His Arg Glu Leu Pro Leu His 
        35                  40                  45              


Leu Asn Lys Arg Tyr Gly Ala Val Ile Lys Arg Leu Ser His Leu Glu 
    50                  55                  60                  


Val Glu Leu Gln Asp Leu Lys Glu Ser Met Lys Leu Ala Leu Arg Gln 
65                  70                  75                  80  


Gln Glu Asn Val Asn Ser Thr Leu Lys Arg Ala Lys Asp Glu Val Arg 
                85                  90                  95      


Pro Leu Leu Lys Ala Met Glu Thr Lys Val Asn Glu Thr Lys Lys His 
            100                 105                 110         


Lys Thr Gln Met Lys Leu Phe Pro His Ser Gln Leu Phe Arg Gln Trp 
        115                 120                 125             


Gly Glu Asp Leu Ser Glu Ala Gln Gln Lys Ala Ala Gln Asp Leu Phe 
    130                 135                 140                 


Arg Lys Phe Gly Tyr Asn Ala Tyr Leu Ser Asn Gln Leu Pro Leu Asn 
145                 150                 155                 160 


Arg Thr Ile Pro Asp Thr Arg Asp Tyr Arg Cys Leu Arg Lys Thr Tyr 
                165                 170                 175     


Pro Ser Gln Leu Pro Ser Leu Ser Val Ile Leu Ile Phe Val Asn Glu 
            180                 185                 190         


Ala Leu Ser Ile Ile Gln Arg Ala Ile Thr Ser Ile Ile Asn Arg Thr 
        195                 200                 205             


Pro Ser Arg Leu Leu Lys Glu Ile Ile Leu Val Asp Asp Phe Ser Ser 
    210                 215                 220                 


Asn Gly Glu Leu Lys Val His Leu Asp Glu Lys Ile Lys Leu Tyr Asn 
225                 230                 235                 240 


Gln Lys Tyr Pro Gly Leu Leu Lys Ile Ile Arg His Pro Glu Arg Lys 
                245                 250                 255     


Gly Leu Ala Gln Ala Arg Asn Thr Gly Trp Glu Ala Ala Thr Ala Asp 
            260                 265                 270         


Val Val Ala Ile Leu Asp Ala His Ile Glu Val Asn Val Gly Trp Ala 
        275                 280                 285             


Glu Pro Ile Leu Ala Arg Ile Gln Glu Asp Arg Thr Val Ile Val Ser 
    290                 295                 300                 


Pro Val Phe Asp Asn Ile Arg Phe Asp Thr Phe Lys Leu Asp Lys Tyr 
305                 310                 315                 320 


Glu Leu Ala Val Asp Gly Phe Asn Trp Glu Leu Trp Cys Arg Tyr Asp 
                325                 330                 335     


Ala Leu Pro Gln Ala Trp Ile Asp Leu His Asp Val Thr Ala Pro Val 
            340                 345                 350         


Lys Ser Pro Ser Ile Met Gly Ile Leu Ala Ala Asn Arg His Phe Leu 
        355                 360                 365             


Gly Glu Ile Gly Ser Leu Asp Gly Gly Met Leu Ile Tyr Gly Gly Glu 
    370                 375                 380                 


Asn Val Glu Leu Ser Leu Arg Val Trp Gln Cys Gly Gly Lys Val Glu 
385                 390                 395                 400 


Ile Leu Pro Cys Ser Arg Ile Ala His Leu Glu Arg His His Lys Pro 
                405                 410                 415     


Tyr Ala Leu Asp Leu Thr Ala Ala Leu Lys Arg Asn Ala Leu Arg Val 
            420                 425                 430         


Ala Glu Ile Trp Met Asp Glu His Lys His Met Val Tyr Leu Ala Trp 
        435                 440                 445             


Asn Ile Pro Leu Gln Asn Ser Gly Ile Asp Phe Gly Asp Val Ser Ser 
    450                 455                 460                 


Arg Met Ala Leu Arg Glu Lys Leu Lys Cys Lys Thr Phe Asp Trp Tyr 
465                 470                 475                 480 


Leu Lys Asn Val Tyr Pro Leu Leu Lys Pro Leu His Thr Ile Val Gly 
                485                 490                 495     


Tyr Gly Arg Met Lys Asn Leu Leu Asp Glu Asn Val Cys Leu Asp Gln 
            500                 505                 510         


Gly Pro Val Pro Gly Asn Thr Pro Ile Met Tyr Tyr Cys His Glu Phe 
        515                 520                 525             


Ser Ser Gln Asn Val Tyr Tyr His Leu Thr Gly Glu Leu Tyr Val Gly 
    530                 535                 540                 


Gln Leu Ile Ala Glu Ala Ser Ala Ser Asp Arg Cys Leu Thr Asp Pro 
545                 550                 555                 560 


Gly Lys Ala Glu Lys Pro Thr Leu Glu Pro Cys Ser Lys Ala Ala Lys 
                565                 570                 575     


Asn Arg Leu His Ile Tyr Trp Asp Phe Lys Pro Gly Gly Ala Val Ile 
            580                 585                 590         


Asn Arg Asp Thr Lys Arg Cys Leu Glu Met Lys Lys Asp Leu Leu Gly 
        595                 600                 605             


Ser His Val Leu Val Leu Gln Thr Cys Ser Thr Gln Val Trp Glu Ile 
    610                 615                 620                 


Gln His Thr Val Arg Asp Trp Gly Gln Thr Asn Ser Gln 
625                 630                 635         


<210>  10
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Val Ala Arg Lys Ile Arg Thr Leu Leu Thr Val Asn Ile Leu 
1               5                   10                  15      


Val Phe Val Gly Ile Val Leu Phe Ser Val Tyr Cys Arg Leu Gln Gly 
            20                  25                  30          


Arg Ser Gln Glu Leu Val Arg Ile Val Ser Gly Asp Arg Arg Val Arg 
        35                  40                  45              


Ser Arg His Ala Lys Val Gly Thr Leu Gly Asp Arg Glu Ala Ile Leu 
    50                  55                  60                  


Gln Arg Leu Asp His Leu Glu Glu Val Val Tyr Asn Gln Leu Asn Gly 
65                  70                  75                  80  


Leu Ala Lys Pro Ile Gly Leu Val Glu Gly Pro Gly Gly Leu Gly Gln 
                85                  90                  95      


Gly Gly Leu Ala Ala Thr Leu Arg Asp Asp Gly Gln Glu Ala Glu Gly 
            100                 105                 110         


Lys Tyr Glu Glu Tyr Gly Tyr Asn Ala Gln Leu Ser Asp Arg Ile Ser 
        115                 120                 125             


Leu Asp Arg Ser Ile Pro Asp Tyr Arg Pro Arg Lys Cys Arg Gln Met 
    130                 135                 140                 


Ser Tyr Ala Gln Asp Leu Pro Gln Val Ser Val Val Phe Ile Phe Val 
145                 150                 155                 160 


Asn Glu Ala Leu Ser Val Ile Leu Arg Ser Val His Ser Val Val Asn 
                165                 170                 175     


His Thr Pro Ser Gln Leu Leu Lys Glu Val Ile Leu Val Asp Asp Asn 
            180                 185                 190         


Ser Asp Asn Val Glu Leu Lys Phe Asn Leu Asp Gln Tyr Val Asn Lys 
        195                 200                 205             


Arg Tyr Pro Gly Leu Val Lys Ile Val Arg Asn Ser Arg Arg Glu Gly 
    210                 215                 220                 


Leu Ile Arg Ala Arg Leu Gln Gly Trp Lys Ala Ala Thr Ala Pro Val 
225                 230                 235                 240 


Val Gly Phe Phe Asp Ala His Val Glu Phe Asn Thr Gly Trp Ala Glu 
                245                 250                 255     


Pro Ala Leu Ser Arg Ile Arg Glu Asp Arg Arg Arg Ile Val Leu Pro 
            260                 265                 270         


Ala Ile Asp Asn Ile Lys Tyr Ser Thr Phe Glu Val Gln Gln Tyr Ala 
        275                 280                 285             


Asn Ala Ala His Gly Tyr Asn Trp Gly Leu Arg Cys Met Tyr Ile Ile 
    290                 295                 300                 


Pro Pro Gln Asp Trp Leu Asp Arg Gly Asp Glu Ser Ala Pro Ile Arg 
305                 310                 315                 320 


Thr Pro Ala Met Ile Gly Cys Ser Phe Val Val Asp Arg Glu Tyr Phe 
                325                 330                 335     


Gly Asp Ile Gly Leu Leu Asp Pro Gly Met Glu Val Tyr Gly Gly Glu 
            340                 345                 350         


Asn Val Glu Leu Gly Met Arg Val Trp Gln Cys Gly Gly Ser Met Glu 
        355                 360                 365             


Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Thr Arg Lys Pro 
    370                 375                 380                 


Tyr Asn Asn Asp Ile Asp Tyr Tyr Ala Lys Arg Asn Ala Leu Arg Ala 
385                 390                 395                 400 


Ala Glu Val Trp Met Asp Asp Phe Lys Ser His Val Tyr Met Ala Trp 
                405                 410                 415     


Asn Ile Pro Met Ser Asn Pro Gly Val Asp Phe Gly Asp Val Ser Glu 
            420                 425                 430         


Arg Leu Ala Leu Arg Gln Arg Leu Lys Cys Arg Ser Phe Lys Trp Tyr 
        435                 440                 445             


Leu Glu Asn Val Tyr Pro Glu Met Arg Val Tyr Asn Asn Thr Leu Thr 
    450                 455                 460                 


Tyr Gly Glu Val Arg Asn Ser Lys Ala Ser Ala Tyr Cys Leu Asp Gln 
465                 470                 475                 480 


Gly Ala Glu Asp Gly Asp Arg Ala Ile Leu Tyr Pro Cys His Gly Met 
                485                 490                 495     


Ser Ser Gln Leu Val Arg Tyr Ser Ala Asp Gly Leu Leu Gln Leu Gly 
            500                 505                 510         


Pro Leu Gly Ser Thr Ala Phe Leu Pro Asp Ser Lys Cys Leu Val Asp 
        515                 520                 525             


Asp Gly Thr Gly Arg Met Pro Thr Leu Lys Lys Cys Glu Asp Val Ala 
    530                 535                 540                 


Arg Pro Thr Gln Arg Leu Trp Asp Phe Thr Gln Ser Gly Pro Ile Val 
545                 550                 555                 560 


Ser Arg Ala Thr Gly Arg Cys Leu Glu Val Glu Met Ser Lys Asp Ala 
                565                 570                 575     


Asn Phe Gly Leu Arg Leu Val Val Gln Arg Cys Ser Gly Gln Lys Trp 
            580                 585                 590         


Met Ile Arg Asn Trp Ile Lys His Ala Arg His 
        595                 600             


<210>  11
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Arg Lys Glu Lys Arg Leu Leu Gln Ala Val Ala Leu Val Leu 
1               5                   10                  15      


Ala Ala Leu Val Leu Leu Pro Asn Val Gly Leu Trp Ala Leu Tyr Arg 
            20                  25                  30          


Glu Arg Gln Pro Asp Gly Thr Pro Gly Gly Ser Gly Ala Ala Val Ala 
        35                  40                  45              


Pro Ala Ala Gly Gln Gly Ser His Ser Arg Gln Lys Lys Thr Phe Phe 
    50                  55                  60                  


Leu Gly Asp Gly Gln Lys Leu Lys Asp Trp His Asp Lys Glu Ala Ile 
65                  70                  75                  80  


Arg Arg Asp Ala Gln Arg Val Gly Asn Gly Glu Gln Gly Arg Pro Tyr 
                85                  90                  95      


Pro Met Thr Asp Ala Glu Arg Val Asp Gln Ala Tyr Arg Glu Asn Gly 
            100                 105                 110         


Phe Asn Ile Tyr Val Ser Asp Lys Ile Ser Leu Asn Arg Ser Leu Pro 
        115                 120                 125             


Asp Ile Arg His Pro Asn Cys Asn Ser Lys Arg Tyr Leu Glu Thr Leu 
    130                 135                 140                 


Pro Asn Thr Ser Ile Ile Ile Pro Phe His Asn Glu Gly Trp Ser Ser 
145                 150                 155                 160 


Leu Leu Arg Thr Val His Ser Val Leu Asn Arg Ser Pro Pro Glu Leu 
                165                 170                 175     


Val Ala Glu Ile Val Leu Val Asp Asp Phe Ser Asp Arg Glu His Leu 
            180                 185                 190         


Lys Lys Pro Leu Glu Asp Tyr Met Ala Leu Phe Pro Ser Val Arg Ile 
        195                 200                 205             


Leu Arg Thr Lys Lys Arg Glu Gly Leu Ile Arg Thr Arg Met Leu Gly 
    210                 215                 220                 


Ala Ser Val Ala Thr Gly Asp Val Ile Thr Phe Leu Asp Ser His Cys 
225                 230                 235                 240 


Glu Ala Asn Val Asn Trp Leu Pro Pro Leu Leu Asp Arg Ile Ala Arg 
                245                 250                 255     


Asn Arg Lys Thr Ile Val Cys Pro Met Ile Asp Val Ile Asp His Asp 
            260                 265                 270         


Asp Phe Arg Tyr Glu Thr Gln Ala Gly Asp Ala Met Arg Gly Ala Phe 
        275                 280                 285             


Asp Trp Glu Met Tyr Tyr Lys Arg Ile Pro Ile Pro Pro Glu Leu Gln 
    290                 295                 300                 


Lys Ala Asp Pro Ser Asp Pro Phe Glu Ser Pro Val Met Ala Gly Gly 
305                 310                 315                 320 


Leu Phe Ala Val Asp Arg Lys Trp Phe Trp Glu Leu Gly Gly Tyr Asp 
                325                 330                 335     


Pro Gly Leu Glu Ile Trp Gly Gly Glu Gln Tyr Glu Ile Ser Phe Lys 
            340                 345                 350         


Val Trp Met Cys Gly Gly Arg Met Glu Asp Ile Pro Cys Ser Arg Val 
        355                 360                 365             


Gly His Ile Tyr Arg Lys Tyr Val Pro Tyr Lys Val Pro Ala Gly Val 
    370                 375                 380                 


Ser Leu Ala Arg Asn Leu Lys Arg Val Ala Glu Val Trp Met Asp Glu 
385                 390                 395                 400 


Tyr Ala Glu Tyr Ile Tyr Gln Arg Arg Pro Glu Tyr Arg His Leu Ser 
                405                 410                 415     


Ala Gly Asp Val Ala Val Gln Lys Lys Leu Arg Ser Ser Leu Asn Cys 
            420                 425                 430         


Lys Ser Phe Lys Trp Phe Met Thr Lys Ile Ala Trp Asp Leu Pro Lys 
        435                 440                 445             


Phe Tyr Pro Pro Val Glu Pro Pro Ala Ala Ala Trp Gly Glu Ile Arg 
    450                 455                 460                 


Asn Val Gly Thr Gly Leu Cys Ala Asp Thr Lys His Gly Ala Leu Gly 
465                 470                 475                 480 


Ser Pro Leu Arg Leu Glu Gly Cys Val Arg Gly Arg Gly Glu Ala Ala 
                485                 490                 495     


Trp Asn Asn Met Gln Val Phe Thr Phe Thr Trp Arg Glu Asp Ile Arg 
            500                 505                 510         


Pro Gly Asp Pro Gln His Thr Lys Lys Phe Cys Phe Asp Ala Ile Ser 
        515                 520                 525             


His Thr Ser Pro Val Thr Leu Tyr Asp Cys His Ser Met Lys Gly Asn 
    530                 535                 540                 


Gln Leu Trp Lys Tyr Arg Lys Asp Lys Thr Leu Tyr His Pro Val Ser 
545                 550                 555                 560 


Gly Ser Cys Met Asp Cys Ser Glu Ser Asp His Arg Ile Phe Met Asn 
                565                 570                 575     


Thr Cys Asn Pro Ser Ser Leu Thr Gln Gln Trp Leu Phe Glu His Thr 
            580                 585                 590         


Asn Ser Thr Val Leu Glu Lys Phe Asn Arg Asn 
        595                 600             


<210>  12
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Ser Val Thr Val Arg Tyr Phe Cys Tyr Gly Cys Leu Phe Thr 
1               5                   10                  15      


Ser Ala Thr Trp Thr Val Leu Leu Phe Val Tyr Phe Asn Phe Ser Glu 
            20                  25                  30          


Val Thr Gln Pro Leu Lys Asn Val Pro Val Lys Gly Ser Gly Pro His 
        35                  40                  45              


Gly Pro Ser Pro Lys Lys Phe Tyr Pro Arg Phe Thr Arg Gly Pro Ser 
    50                  55                  60                  


Arg Val Leu Glu Pro Gln Phe Lys Ala Asn Lys Ile Asp Asp Val Ile 
65                  70                  75                  80  


Asp Ser Arg Val Glu Asp Pro Glu Glu Gly His Leu Lys Phe Ser Ser 
                85                  90                  95      


Glu Leu Gly Met Ile Phe Asn Glu Arg Asp Gln Glu Leu Arg Asp Leu 
            100                 105                 110         


Gly Tyr Gln Lys His Ala Phe Asn Met Leu Ile Ser Asp Arg Leu Gly 
        115                 120                 125             


Tyr His Arg Asp Val Pro Asp Thr Arg Asn Ala Ala Cys Lys Glu Lys 
    130                 135                 140                 


Phe Tyr Pro Pro Asp Leu Pro Ala Ala Ser Val Val Ile Cys Phe Tyr 
145                 150                 155                 160 


Asn Glu Ala Phe Ser Ala Leu Leu Arg Thr Val His Ser Val Ile Asp 
                165                 170                 175     


Arg Thr Pro Ala His Leu Leu His Glu Ile Ile Leu Val Asp Asp Asp 
            180                 185                 190         


Ser Asp Phe Asp Asp Leu Lys Gly Glu Leu Asp Glu Tyr Val Gln Lys 
        195                 200                 205             


Tyr Leu Pro Gly Lys Ile Lys Val Ile Arg Asn Thr Lys Arg Glu Gly 
    210                 215                 220                 


Leu Ile Arg Gly Arg Met Ile Gly Ala Ala His Ala Thr Gly Glu Val 
225                 230                 235                 240 


Leu Val Phe Leu Asp Ser His Cys Glu Val Asn Val Met Trp Leu Gln 
                245                 250                 255     


Pro Leu Leu Ala Ala Ile Arg Glu Asp Arg His Thr Val Val Cys Pro 
            260                 265                 270         


Val Ile Asp Ile Ile Ser Ala Asp Thr Leu Ala Tyr Ser Ser Ser Pro 
        275                 280                 285             


Val Val Arg Gly Gly Phe Asn Trp Gly Leu His Phe Lys Trp Asp Leu 
    290                 295                 300                 


Val Pro Leu Ser Glu Leu Gly Arg Ala Glu Gly Ala Thr Ala Pro Ile 
305                 310                 315                 320 


Lys Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Met Asn Arg Gln Tyr 
                325                 330                 335     


Phe His Glu Leu Gly Gln Tyr Asp Ser Gly Met Asp Ile Trp Gly Gly 
            340                 345                 350         


Glu Asn Leu Glu Ile Ser Phe Arg Ile Trp Met Cys Gly Gly Lys Leu 
        355                 360                 365             


Phe Ile Ile Pro Cys Ser Arg Val Gly His Ile Phe Arg Lys Arg Arg 
    370                 375                 380                 


Pro Tyr Gly Ser Pro Glu Gly Gln Asp Thr Met Thr His Asn Ser Leu 
385                 390                 395                 400 


Arg Leu Ala His Val Trp Leu Asp Glu Tyr Lys Glu Gln Tyr Phe Ser 
                405                 410                 415     


Leu Arg Pro Asp Leu Lys Thr Lys Ser Tyr Gly Asn Ile Ser Glu Arg 
            420                 425                 430         


Val Glu Leu Arg Lys Lys Leu Gly Cys Lys Ser Phe Lys Trp Tyr Leu 
        435                 440                 445             


Asp Asn Val Tyr Pro Glu Met Gln Ile Ser Gly Ser His Ala Lys Pro 
    450                 455                 460                 


Gln Gln Pro Ile Phe Val Asn Arg Gly Pro Lys Arg Pro Lys Val Leu 
465                 470                 475                 480 


Gln Arg Gly Arg Leu Tyr His Leu Gln Thr Asn Lys Cys Leu Val Ala 
                485                 490                 495     


Gln Gly Arg Pro Ser Gln Lys Gly Gly Leu Val Val Leu Lys Ala Cys 
            500                 505                 510         


Asp Tyr Ser Asp Pro Asn Gln Ile Trp Ile Tyr Asn Glu Glu His Glu 
        515                 520                 525             


Leu Val Leu Asn Ser Leu Leu Cys Leu Asp Met Ser Glu Thr Arg Ser 
    530                 535                 540                 


Ser Asp Pro Pro Arg Leu Met Lys Cys His Gly Ser Gly Gly Ser Gln 
545                 550                 555                 560 


Gln Trp Thr Phe Gly Lys Asn Asn Arg Leu Tyr Gln Val Ser Val Gly 
                565                 570                 575     


Gln Cys Leu Arg Ala Val Asp Pro Leu Gly Gln Lys Gly Ser Val Ala 
            580                 585                 590         


Met Ala Ile Cys Asp Gly Ser Ser Ser Gln Gln Trp His Leu Glu Gly 
        595                 600                 605             


<210>  13
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Trp Gly Arg Thr Ala Arg Arg Arg Cys Pro Arg Glu Leu Arg Arg 
1               5                   10                  15      


Gly Arg Glu Ala Leu Leu Val Leu Leu Ala Leu Leu Ala Leu Ala Gly 
            20                  25                  30          


Leu Gly Ser Val Leu Arg Ala Gln Arg Gly Ala Gly Ala Gly Ala Ala 
        35                  40                  45              


Glu Pro Gly Pro Pro Arg Thr Pro Arg Pro Gly Arg Arg Glu Pro Val 
    50                  55                  60                  


Met Pro Arg Pro Pro Val Pro Ala Asn Ala Leu Gly Ala Arg Gly Glu 
65                  70                  75                  80  


Ala Val Arg Leu Gln Leu Gln Gly Glu Glu Leu Arg Leu Gln Glu Glu 
                85                  90                  95      


Ser Val Arg Leu His Gln Ile Asn Ile Tyr Leu Ser Asp Arg Ile Ser 
            100                 105                 110         


Leu His Arg Arg Leu Pro Glu Arg Trp Asn Pro Leu Cys Lys Glu Lys 
        115                 120                 125             


Lys Tyr Asp Tyr Asp Asn Leu Pro Arg Thr Ser Val Ile Ile Ala Phe 
    130                 135                 140                 


Tyr Asn Glu Ala Trp Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Leu 
145                 150                 155                 160 


Glu Thr Ser Pro Asp Ile Leu Leu Glu Glu Val Ile Leu Val Asp Asp 
                165                 170                 175     


Tyr Ser Asp Arg Glu His Leu Lys Glu Arg Leu Ala Asn Glu Leu Ser 
            180                 185                 190         


Gly Leu Pro Lys Val Arg Leu Ile Arg Ala Asn Lys Arg Glu Gly Leu 
        195                 200                 205             


Val Arg Ala Arg Leu Leu Gly Ala Ser Ala Ala Arg Gly Asp Val Leu 
    210                 215                 220                 


Thr Phe Leu Asp Cys His Cys Glu Cys His Glu Gly Trp Leu Glu Pro 
225                 230                 235                 240 


Leu Leu Gln Arg Ile His Glu Glu Glu Ser Ala Val Val Cys Pro Val 
                245                 250                 255     


Ile Asp Val Ile Asp Trp Asn Thr Phe Glu Tyr Leu Gly Asn Ser Gly 
            260                 265                 270         


Glu Pro Gln Ile Gly Gly Phe Asp Trp Arg Leu Val Phe Thr Trp His 
        275                 280                 285             


Thr Val Pro Glu Arg Glu Arg Ile Arg Met Gln Ser Pro Val Asp Val 
    290                 295                 300                 


Ile Arg Ser Pro Thr Met Ala Gly Gly Leu Phe Ala Val Ser Lys Lys 
305                 310                 315                 320 


Tyr Phe Glu Tyr Leu Gly Ser Tyr Asp Thr Gly Met Glu Val Trp Gly 
                325                 330                 335     


Gly Glu Asn Leu Glu Phe Ser Phe Arg Ile Trp Gln Cys Gly Gly Val 
            340                 345                 350         


Leu Glu Thr His Pro Cys Ser His Val Gly His Val Phe Pro Lys Gln 
        355                 360                 365             


Ala Pro Tyr Ser Arg Asn Lys Ala Leu Ala Asn Ser Val Arg Ala Ala 
    370                 375                 380                 


Glu Val Trp Met Asp Glu Phe Lys Glu Leu Tyr Tyr His Arg Asn Pro 
385                 390                 395                 400 


Arg Ala Arg Leu Glu Pro Phe Gly Asp Val Thr Glu Arg Lys Gln Leu 
                405                 410                 415     


Arg Asp Lys Leu Gln Cys Lys Asp Phe Lys Trp Phe Leu Glu Thr Val 
            420                 425                 430         


Tyr Pro Glu Leu His Val Pro Glu Asp Arg Pro Gly Phe Phe Gly Met 
        435                 440                 445             


Leu Gln Asn Lys Gly Leu Thr Asp Tyr Cys Phe Asp Tyr Asn Pro Pro 
    450                 455                 460                 


Asp Glu Asn Gln Ile Val Gly His Gln Val Ile Leu Tyr Leu Cys His 
465                 470                 475                 480 


Gly Met Gly Gln Asn Gln Phe Phe Glu Tyr Thr Ser Gln Lys Glu Ile 
                485                 490                 495     


Arg Tyr Asn Thr His Gln Pro Glu Gly Cys Ile Ala Val Glu Ala Gly 
            500                 505                 510         


Met Asp Thr Leu Ile Met His Leu Cys Glu Glu Thr Ala Pro Glu Asn 
        515                 520                 525             


Gln Lys Phe Ile Leu Gln Glu Asp Gly Ser Leu Phe His Glu Gln Ser 
    530                 535                 540                 


Lys Lys Cys Val Gln Ala Ala Arg Lys Glu Ser Ser Asp Ser Phe Val 
545                 550                 555                 560 


Pro Leu Leu Arg Asp Cys Thr Asn Ser Asp His Gln Lys Trp Phe Phe 
                565                 570                 575     


Lys Glu Arg Met Leu 
            580     


<210>  14
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Arg Phe Val Tyr Cys Lys Val Val Leu Ala Thr Ser Leu Met 
1               5                   10                  15      


Trp Val Leu Val Asp Val Phe Leu Leu Leu Tyr Phe Ser Glu Cys Asn 
            20                  25                  30          


Lys Cys Asp Asp Lys Lys Glu Arg Ser Leu Leu Pro Ala Leu Arg Ala 
        35                  40                  45              


Val Ile Ser Arg Asn Gln Glu Gly Pro Gly Glu Met Gly Lys Ala Val 
    50                  55                  60                  


Leu Ile Pro Lys Asp Asp Gln Glu Lys Met Lys Glu Leu Phe Lys Ile 
65                  70                  75                  80  


Asn Gln Phe Asn Leu Met Ala Ser Asp Leu Ile Ala Leu Asn Arg Ser 
                85                  90                  95      


Leu Pro Asp Val Arg Leu Glu Gly Cys Lys Thr Lys Val Tyr Pro Asp 
            100                 105                 110         


Glu Leu Pro Asn Thr Ser Val Val Ile Val Phe His Asn Glu Ala Trp 
        115                 120                 125             


Ser Thr Leu Leu Arg Thr Val Tyr Ser Val Ile Asn Arg Ser Pro His 
    130                 135                 140                 


Tyr Leu Leu Ser Glu Val Ile Leu Val Asp Asp Ala Ser Glu Arg Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Thr Leu Glu Asn Tyr Val Lys Asn Leu Glu Val Pro 
                165                 170                 175     


Val Lys Ile Ile Arg Met Glu Glu Arg Ser Gly Leu Ile Arg Ala Arg 
            180                 185                 190         


Leu Arg Gly Ala Ala Ala Ser Lys Gly Gln Val Ile Thr Phe Leu Asp 
        195                 200                 205             


Ala His Cys Glu Cys Thr Leu Gly Trp Leu Glu Pro Leu Leu Ala Arg 
    210                 215                 220                 


Ile Lys Glu Asp Arg Lys Thr Val Val Cys Pro Ile Ile Asp Val Ile 
225                 230                 235                 240 


Ser Asp Asp Thr Phe Glu Tyr Met Ala Gly Ser Asp Met Thr Tyr Gly 
                245                 250                 255     


Gly Phe Asn Trp Lys Leu Asn Phe Arg Trp Tyr Pro Val Pro Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Arg Lys Gly Asp Arg Thr Leu Pro Val Arg Thr Pro 
        275                 280                 285             


Thr Met Ala Gly Gly Leu Phe Ser Ile Asp Arg Asn Tyr Phe Glu Glu 
    290                 295                 300                 


Ile Gly Thr Tyr Asp Ala Gly Met Asp Ile Trp Gly Gly Glu Asn Leu 
305                 310                 315                 320 


Glu Met Ser Phe Arg Ile Trp Gln Cys Gly Gly Ser Leu Glu Ile Val 
                325                 330                 335     


Thr Cys Ser His Val Gly His Val Phe Arg Lys Ala Thr Pro Tyr Thr 
            340                 345                 350         


Phe Pro Gly Gly Thr Gly His Val Ile Asn Lys Asn Asn Arg Arg Leu 
        355                 360                 365             


Ala Glu Val Trp Met Asp Glu Phe Lys Asp Phe Phe Tyr Ile Ile Ser 
    370                 375                 380                 


Pro Gly Val Val Lys Val Asp Tyr Gly Asp Val Ser Val Arg Lys Thr 
385                 390                 395                 400 


Leu Arg Glu Asn Leu Lys Cys Lys Pro Phe Ser Trp Tyr Leu Glu Asn 
                405                 410                 415     


Ile Tyr Pro Asp Ser Gln Ile Pro Arg Arg Tyr Tyr Ser Leu Gly Glu 
            420                 425                 430         


Ile Arg Asn Val Glu Thr Asn Gln Cys Leu Asp Asn Met Gly Arg Lys 
        435                 440                 445             


Glu Asn Glu Lys Val Gly Ile Phe Asn Cys His Gly Met Gly Gly Asn 
    450                 455                 460                 


Gln Val Phe Ser Tyr Thr Ala Asp Lys Glu Ile Arg Thr Asp Asp Leu 
465                 470                 475                 480 


Cys Leu Asp Val Ser Arg Leu Asn Gly Pro Val Ile Met Leu Lys Cys 
                485                 490                 495     


His His Met Arg Gly Asn Gln Leu Trp Glu Tyr Asp Ala Glu Arg Leu 
            500                 505                 510         


Thr Leu Arg His Val Asn Ser Asn Gln Cys Leu Asp Glu Pro Ser Glu 
        515                 520                 525             


Glu Asp Lys Met Val Pro Thr Met Gln Asp Cys Ser Gly Ser Arg Ser 
    530                 535                 540                 


Gln Gln Trp Leu Leu Arg Asn Met Thr Leu Gly Thr 
545                 550                 555     


<210>  15
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Arg Leu Thr Arg Arg Leu Val Leu Pro Val Phe Gly Val Leu 
1               5                   10                  15      


Trp Ile Thr Val Leu Leu Phe Phe Trp Val Thr Lys Arg Lys Leu Glu 
            20                  25                  30          


Val Pro Thr Gly Pro Glu Val Gln Thr Pro Lys Pro Ser Asp Ala Asp 
        35                  40                  45              


Trp Asp Asp Leu Trp Asp Gln Phe Asp Glu Arg Arg Tyr Leu Asn Ala 
    50                  55                  60                  


Lys Lys Trp Arg Val Gly Asp Asp Pro Tyr Lys Leu Tyr Ala Phe Asn 
65                  70                  75                  80  


Gln Arg Glu Ser Glu Arg Ile Ser Ser Asn Arg Ala Ile Pro Asp Thr 
                85                  90                  95      


Arg His Leu Arg Cys Thr Leu Leu Val Tyr Cys Thr Asp Leu Pro Pro 
            100                 105                 110         


Thr Ser Ile Ile Ile Thr Phe His Asn Glu Ala Arg Ser Thr Leu Leu 
        115                 120                 125             


Arg Thr Ile Arg Ser Val Leu Asn Arg Thr Pro Thr His Leu Ile Arg 
    130                 135                 140                 


Glu Ile Ile Leu Val Asp Asp Phe Ser Asn Asp Pro Asp Asp Cys Lys 
145                 150                 155                 160 


Gln Leu Ile Lys Leu Pro Lys Val Lys Cys Leu Arg Asn Asn Glu Arg 
                165                 170                 175     


Gln Gly Leu Val Arg Ser Arg Ile Arg Gly Ala Asp Ile Ala Gln Gly 
            180                 185                 190         


Thr Thr Leu Thr Phe Leu Asp Ser His Cys Glu Val Asn Arg Asp Trp 
        195                 200                 205             


Leu Gln Pro Leu Leu His Arg Val Lys Glu Asp Tyr Thr Arg Val Val 
    210                 215                 220                 


Cys Pro Val Ile Asp Ile Ile Asn Leu Asp Thr Phe Thr Tyr Ile Glu 
225                 230                 235                 240 


Ser Ala Ser Glu Leu Arg Gly Gly Phe Asp Trp Ser Leu His Phe Gln 
                245                 250                 255     


Trp Glu Gln Leu Ser Pro Glu Gln Lys Ala Arg Arg Leu Asp Pro Thr 
            260                 265                 270         


Glu Pro Ile Arg Thr Pro Ile Ile Ala Gly Gly Leu Phe Val Ile Asp 
        275                 280                 285             


Lys Ala Trp Phe Asp Tyr Leu Gly Lys Tyr Asp Met Asp Met Asp Ile 
    290                 295                 300                 


Trp Gly Gly Glu Asn Phe Glu Ile Ser Phe Arg Val Trp Met Cys Gly 
305                 310                 315                 320 


Gly Ser Leu Glu Ile Val Pro Cys Ser Arg Val Gly His Val Phe Arg 
                325                 330                 335     


Lys Lys His Pro Tyr Val Phe Pro Asp Gly Asn Ala Asn Thr Tyr Ile 
            340                 345                 350         


Lys Asn Thr Lys Arg Thr Ala Glu Val Trp Met Asp Glu Tyr Lys Gln 
        355                 360                 365             


Tyr Tyr Tyr Ala Ala Arg Pro Phe Ala Leu Glu Arg Pro Phe Gly Asn 
    370                 375                 380                 


Val Glu Ser Arg Leu Asp Leu Arg Lys Asn Leu Arg Cys Gln Ser Phe 
385                 390                 395                 400 


Lys Trp Tyr Leu Glu Asn Ile Tyr Pro Glu Leu Ser Ile Pro Lys Glu 
                405                 410                 415     


Ser Ser Ile Gln Lys Gly Asn Ile Arg Gln Arg Gln Lys Cys Leu Glu 
            420                 425                 430         


Ser Gln Arg Gln Asn Asn Gln Glu Thr Pro Asn Leu Lys Leu Ser Pro 
        435                 440                 445             


Cys Ala Lys Val Lys Gly Glu Asp Ala Lys Ser Gln Val Trp Ala Phe 
    450                 455                 460                 


Thr Tyr Thr Gln Gln Ile Leu Gln Glu Glu Leu Cys Leu Ser Val Ile 
465                 470                 475                 480 


Thr Leu Phe Pro Gly Ala Pro Val Val Leu Val Leu Cys Lys Asn Gly 
                485                 490                 495     


Asp Asp Arg Gln Gln Trp Thr Lys Thr Gly Ser His Ile Glu His Ile 
            500                 505                 510         


Ala Ser His Leu Cys Leu Asp Thr Asp Met Phe Gly Asp Gly Thr Glu 
        515                 520                 525             


Asn Gly Lys Glu Ile Val Val Asn Pro Cys Glu Ser Ser Leu Met Ser 
    530                 535                 540                 


Gln His Trp Asp Met Val Ser Ser 
545                 550         


<210>  16
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Leu Leu Arg Lys Arg Tyr Arg His Arg Pro Cys Arg Leu Gln Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Met Leu Gly Cys Val Leu Met Met Val Ala Met 
            20                  25                  30          


Leu His Pro Pro His His Thr Leu His Gln Thr Val Thr Ala Gln Ala 
        35                  40                  45              


Ser Lys His Ser Pro Glu Ala Arg Tyr Arg Leu Asp Phe Gly Glu Ser 
    50                  55                  60                  


Gln Asp Trp Val Leu Glu Ala Glu Asp Glu Gly Glu Glu Tyr Ser Pro 
65                  70                  75                  80  


Leu Glu Gly Leu Pro Pro Phe Ile Ser Leu Arg Glu Asp Gln Leu Leu 
                85                  90                  95      


Val Ala Val Ala Leu Pro Gln Ala Arg Arg Asn Gln Ser Gln Gly Arg 
            100                 105                 110         


Arg Gly Gly Ser Tyr Arg Leu Ile Lys Gln Pro Arg Arg Gln Asp Lys 
        115                 120                 125             


Glu Ala Pro Lys Arg Asp Trp Gly Ala Asp Glu Asp Gly Glu Val Ser 
    130                 135                 140                 


Glu Glu Glu Glu Leu Thr Pro Phe Ser Leu Asp Pro Arg Gly Leu Gln 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Arg Ile Pro Leu Gln Arg Ala Leu Pro Glu Val 
                165                 170                 175     


Arg His Pro Leu Cys Leu Gln Gln His Pro Gln Asp Ser Leu Pro Thr 
            180                 185                 190         


Ala Ser Val Ile Leu Cys Phe His Asp Glu Ala Trp Ser Thr Leu Leu 
        195                 200                 205             


Arg Thr Val His Ser Ile Leu Asp Thr Val Pro Arg Ala Phe Leu Lys 
    210                 215                 220                 


Glu Ile Ile Leu Val Asp Asp Leu Ser Gln Gln Gly Gln Leu Lys Ser 
225                 230                 235                 240 


Ala Leu Ser Glu Tyr Val Ala Arg Leu Glu Gly Val Lys Leu Leu Arg 
                245                 250                 255     


Ser Asn Lys Arg Leu Gly Ala Ile Arg Ala Arg Met Leu Gly Ala Thr 
            260                 265                 270         


Arg Ala Thr Gly Asp Val Leu Val Phe Met Asp Ala His Cys Glu Cys 
        275                 280                 285             


His Pro Gly Trp Leu Glu Pro Leu Leu Ser Arg Ile Ala Gly Asp Arg 
    290                 295                 300                 


Ser Arg Val Val Ser Pro Val Ile Asp Val Ile Asp Trp Lys Thr Phe 
305                 310                 315                 320 


Gln Tyr Tyr Pro Ser Lys Asp Leu Gln Arg Gly Val Leu Asp Trp Lys 
                325                 330                 335     


Leu Asp Phe His Trp Glu Pro Leu Pro Glu His Val Arg Lys Ala Leu 
            340                 345                 350         


Gln Ser Pro Ile Ser Pro Ile Arg Ser Pro Val Val Pro Gly Glu Val 
        355                 360                 365             


Val Ala Met Asp Arg His Tyr Phe Gln Asn Thr Gly Ala Tyr Asp Ser 
    370                 375                 380                 


Leu Met Ser Leu Arg Gly Gly Glu Asn Leu Glu Leu Ser Phe Lys Ala 
385                 390                 395                 400 


Trp Leu Cys Gly Gly Ser Val Glu Ile Leu Pro Cys Ser Arg Val Gly 
                405                 410                 415     


His Ile Tyr Gln Asn Gln Asp Ser His Ser Pro Leu Asp Gln Glu Ala 
            420                 425                 430         


Thr Leu Arg Asn Arg Val Arg Ile Ala Glu Thr Trp Leu Gly Ser Phe 
        435                 440                 445             


Lys Glu Thr Phe Tyr Lys His Ser Pro Glu Ala Phe Ser Leu Ser Lys 
    450                 455                 460                 


Ala Glu Lys Pro Asp Cys Met Glu Arg Leu Gln Leu Gln Arg Arg Leu 
465                 470                 475                 480 


Gly Cys Arg Thr Phe His Trp Phe Leu Ala Asn Val Tyr Pro Glu Leu 
                485                 490                 495     


Tyr Pro Ser Glu Pro Arg Pro Ser Phe Ser Gly Lys Leu His Asn Thr 
            500                 505                 510         


Gly Leu Gly Leu Cys Ala Asp Cys Gln Ala Glu Gly Asp Ile Leu Gly 
        515                 520                 525             


Cys Pro Met Val Leu Ala Pro Cys Ser Asp Ser Arg Gln Gln Gln Tyr 
    530                 535                 540                 


Leu Gln His Thr Ser Arg Lys Glu Ile His Phe Gly Ser Pro Gln His 
545                 550                 555                 560 


Leu Cys Phe Ala Val Arg Gln Glu Gln Val Ile Leu Gln Asn Cys Thr 
                565                 570                 575     


Glu Glu Gly Leu Ala Ile His Gln Gln His Trp Asp Phe Gln Glu Asn 
            580                 585                 590         


Gly Met Ile Val His Ile Leu Ser Gly Lys Cys Met Glu Ala Val Val 
        595                 600                 605             


Gln Glu Asn Asn Lys Asp Leu Tyr Leu Arg Pro Cys Asp Gly Lys Ala 
    610                 615                 620                 


Arg Gln Gln Trp Arg Phe Asp Gln Ile Asn Ala Val Asp Glu Arg 
625                 630                 635                 


<210>  17
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Arg Lys Ile Arg Ala Asn Ala Ile Ala Ile Leu Thr Val Ala Trp 
1               5                   10                  15      


Ile Leu Gly Thr Phe Tyr Tyr Leu Trp Gln Asp Asn Arg Ala His Ala 
            20                  25                  30          


Ala Ser Ser Gly Gly Arg Gly Ala Gln Arg Ala Gly Arg Arg Ser Glu 
        35                  40                  45              


Gln Leu Arg Glu Asp Arg Thr Ile Pro Leu Ile Val Thr Gly Thr Pro 
    50                  55                  60                  


Ser Lys Gly Phe Asp Glu Lys Ala Tyr Leu Ser Ala Lys Gln Leu Lys 
65                  70                  75                  80  


Ala Gly Glu Asp Pro Tyr Arg Gln His Ala Phe Asn Gln Leu Glu Ser 
                85                  90                  95      


Asp Lys Leu Ser Pro Asp Arg Pro Ile Arg Asp Thr Arg His Tyr Ser 
            100                 105                 110         


Cys Pro Ser Val Ser Tyr Ser Ser Asp Leu Pro Ala Thr Ser Val Ile 
        115                 120                 125             


Ile Thr Phe His Asn Glu Ala Arg Ser Thr Leu Leu Arg Thr Val Lys 
    130                 135                 140                 


Ser Val Leu Asn Arg Thr Pro Ala Asn Leu Ile Gln Glu Ile Ile Leu 
145                 150                 155                 160 


Val Asp Asp Phe Ser Ser Asp Pro Glu Asp Cys Leu Leu Leu Thr Arg 
                165                 170                 175     


Ile Pro Lys Val Lys Cys Leu Arg Asn Asp Arg Arg Glu Gly Leu Ile 
            180                 185                 190         


Arg Ser Arg Val Arg Gly Ala Asp Val Ala Ala Ala Thr Val Leu Thr 
        195                 200                 205             


Phe Leu Asp Ser His Cys Glu Val Asn Thr Glu Trp Leu Pro Pro Met 
    210                 215                 220                 


Leu Gln Arg Val Lys Glu Asp His Thr Arg Val Val Ser Pro Ile Ile 
225                 230                 235                 240 


Asp Val Ile Ser Leu Asp Asn Phe Ala Tyr Leu Ala Ala Ser Ala Asp 
                245                 250                 255     


Leu Arg Gly Gly Phe Asp Trp Ser Leu His Phe Lys Trp Glu Gln Ile 
            260                 265                 270         


Pro Leu Glu Gln Lys Met Thr Arg Thr Asp Pro Thr Arg Pro Ile Arg 
        275                 280                 285             


Thr Pro Val Ile Ala Gly Gly Ile Phe Val Ile Asp Lys Ser Trp Phe 
    290                 295                 300                 


Asn His Leu Gly Lys Tyr Asp Ala Gln Met Asp Ile Trp Gly Gly Glu 
305                 310                 315                 320 


Asn Phe Glu Leu Ser Phe Arg Val Trp Met Cys Gly Gly Ser Leu Glu 
                325                 330                 335     


Ile Val Pro Cys Ser Arg Val Gly His Val Phe Arg Lys Arg His Pro 
            340                 345                 350         


Tyr Asn Phe Pro Glu Gly Asn Ala Leu Thr Tyr Ile Arg Asn Thr Lys 
        355                 360                 365             


Arg Thr Ala Glu Val Trp Met Asp Glu Tyr Lys Gln Tyr Tyr Tyr Glu 
    370                 375                 380                 


Ala Arg Pro Ser Ala Ile Gly Lys Ala Phe Gly Ser Val Ala Thr Arg 
385                 390                 395                 400 


Ile Glu Gln Arg Lys Lys Met Asn Cys Lys Ser Phe Arg Trp Tyr Leu 
                405                 410                 415     


Glu Asn Val Tyr Pro Glu Leu Thr Val Pro Val Lys Glu Ala Leu Pro 
            420                 425                 430         


Gly Ile Ile Lys Gln Gly Val Asn Cys Leu Glu Ser Gln Gly Gln Asn 
        435                 440                 445             


Thr Ala Gly Asp Phe Leu Leu Gly Met Gly Ile Cys Arg Gly Ser Ala 
    450                 455                 460                 


Lys Asn Pro Gln Pro Ala Gln Ala Trp Leu Phe Ser Asp His Leu Ile 
465                 470                 475                 480 


Gln Gln Gln Gly Lys Cys Leu Ala Ala Thr Ser Thr Leu Met Ser Ser 
                485                 490                 495     


Pro Gly Ser Pro Val Ile Leu Gln Met Cys Asn Pro Arg Glu Gly Lys 
            500                 505                 510         


Gln Lys Trp Arg Arg Lys Gly Ser Phe Ile Gln His Ser Val Ser Gly 
        515                 520                 525             


Leu Cys Leu Glu Thr Lys Pro Ala Gln Leu Val Thr Ser Lys Cys Gln 
    530                 535                 540                 


Ala Asp Ala Gln Ala Gln Gln Trp Gln Leu Leu Pro His Thr 
545                 550                 555             


<210>  18
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ser Leu Arg Arg Val Lys Val Leu Leu Val Leu Asn Leu Ile 
1               5                   10                  15      


Ala Val Ala Gly Phe Val Leu Phe Leu Ala Lys Cys Arg Pro Ile Ala 
            20                  25                  30          


Val Arg Ser Gly Asp Ala Phe His Glu Ile Arg Pro Arg Ala Glu Val 
        35                  40                  45              


Ala Asn Leu Ser Ala His Ser Ala Ser Pro Ile Gln Asp Ala Val Leu 
    50                  55                  60                  


Lys Arg Leu Ser Leu Leu Glu Asp Ile Val Tyr Arg Gln Leu Asn Gly 
65                  70                  75                  80  


Leu Ser Lys Ser Leu Gly Leu Ile Glu Gly Tyr Gly Gly Arg Gly Lys 
                85                  90                  95      


Gly Gly Leu Pro Ala Thr Leu Ser Pro Ala Glu Glu Glu Lys Ala Lys 
            100                 105                 110         


Gly Pro His Glu Lys Tyr Gly Tyr Asn Ser Tyr Leu Ser Glu Lys Ile 
        115                 120                 125             


Ser Leu Asp Arg Ser Ile Pro Asp Tyr Arg Pro Thr Lys Cys Lys Glu 
    130                 135                 140                 


Leu Lys Tyr Ser Lys Asp Leu Pro Gln Ile Ser Ile Ile Phe Ile Phe 
145                 150                 155                 160 


Val Asn Glu Ala Leu Ser Val Ile Leu Arg Ser Val His Ser Ala Val 
                165                 170                 175     


Asn His Thr Pro Thr His Leu Leu Lys Glu Ile Ile Leu Val Asp Asp 
            180                 185                 190         


Asn Ser Asp Glu Glu Glu Leu Lys Val Pro Leu Glu Glu Tyr Val His 
        195                 200                 205             


Lys Arg Tyr Pro Gly Leu Val Lys Val Val Arg Asn Gln Lys Arg Glu 
    210                 215                 220                 


Gly Leu Ile Arg Ala Arg Ile Glu Gly Trp Lys Val Ala Thr Gly Gln 
225                 230                 235                 240 


Val Thr Gly Phe Phe Asp Ala His Val Glu Phe Thr Ala Gly Trp Ala 
                245                 250                 255     


Glu Pro Val Leu Ser Arg Ile Gln Glu Asn Arg Lys Arg Val Ile Leu 
            260                 265                 270         


Pro Ser Ile Asp Asn Ile Lys Gln Asp Asn Phe Glu Val Gln Arg Tyr 
        275                 280                 285             


Glu Asn Ser Ala His Gly Tyr Ser Trp Glu Leu Trp Cys Met Tyr Ile 
    290                 295                 300                 


Ser Pro Pro Lys Asp Trp Trp Asp Ala Gly Asp Pro Ser Leu Pro Ile 
305                 310                 315                 320 


Arg Thr Pro Ala Met Ile Gly Cys Ser Phe Val Val Asn Arg Lys Phe 
                325                 330                 335     


Phe Gly Glu Ile Gly Leu Leu Asp Pro Gly Met Asp Val Tyr Gly Gly 
            340                 345                 350         


Glu Asn Ile Glu Leu Gly Ile Lys Val Trp Leu Cys Gly Gly Ser Met 
        355                 360                 365             


Glu Val Leu Pro Cys Ser Arg Val Ala His Ile Glu Arg Lys Lys Lys 
    370                 375                 380                 


Pro Tyr Asn Ser Asn Ile Gly Phe Tyr Thr Lys Arg Asn Ala Leu Arg 
385                 390                 395                 400 


Val Ala Glu Val Trp Met Asp Asp Tyr Lys Ser His Val Tyr Ile Ala 
                405                 410                 415     


Trp Asn Leu Pro Leu Glu Asn Pro Gly Ile Asp Ile Gly Asp Val Ser 
            420                 425                 430         


Glu Arg Arg Ala Leu Arg Lys Ser Leu Lys Cys Lys Asn Phe Gln Trp 
        435                 440                 445             


Tyr Leu Asp His Val Tyr Pro Glu Met Arg Arg Tyr Asn Asn Thr Val 
    450                 455                 460                 


Ala Tyr Gly Glu Leu Arg Asn Asn Lys Ala Lys Asp Val Cys Leu Asp 
465                 470                 475                 480 


Gln Gly Pro Leu Glu Asn His Thr Ala Ile Leu Tyr Pro Cys His Gly 
                485                 490                 495     


Trp Gly Pro Gln Leu Ala Arg Tyr Thr Lys Glu Gly Phe Leu His Leu 
            500                 505                 510         


Gly Ala Leu Gly Thr Thr Thr Leu Leu Pro Asp Thr Arg Cys Leu Val 
        515                 520                 525             


Asp Asn Ser Lys Ser Arg Leu Pro Gln Leu Leu Asp Cys Asp Lys Val 
    530                 535                 540                 


Lys Ser Ser Leu Tyr Lys Arg Trp Asn Phe Ile Gln Asn Gly Ala Ile 
545                 550                 555                 560 


Met Asn Lys Gly Thr Gly Arg Cys Leu Glu Val Glu Asn Arg Gly Leu 
                565                 570                 575     


Ala Gly Ile Asp Leu Ile Leu Arg Ser Cys Thr Gly Gln Arg Trp Thr 
            580                 585                 590         


Ile Lys Asn Ser Ile Lys 
        595             


<210>  19
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Val Cys Thr Arg Lys Thr Lys Thr Leu Val Ser Thr Cys Val Ile 
1               5                   10                  15      


Leu Ser Gly Met Thr Asn Ile Ile Cys Leu Leu Tyr Val Gly Trp Val 
            20                  25                  30          


Thr Asn Tyr Ile Ala Ser Val Tyr Val Arg Gly Gln Glu Pro Ala Pro 
        35                  40                  45              


Asp Lys Lys Leu Glu Glu Asp Lys Gly Asp Thr Leu Lys Ile Ile Glu 
    50                  55                  60                  


Arg Leu Asp His Leu Glu Asn Val Ile Lys Gln His Ile Gln Glu Ala 
65                  70                  75                  80  


Pro Ala Lys Pro Glu Glu Ala Glu Ala Glu Pro Phe Thr Asp Ser Ser 
                85                  90                  95      


Leu Phe Ala His Trp Gly Gln Glu Leu Ser Pro Glu Gly Arg Arg Val 
            100                 105                 110         


Ala Leu Lys Gln Phe Gln Tyr Tyr Gly Tyr Asn Ala Tyr Leu Ser Asp 
        115                 120                 125             


Arg Leu Pro Leu Asp Arg Pro Leu Pro Asp Leu Arg Pro Ser Gly Cys 
    130                 135                 140                 


Arg Asn Leu Ser Phe Pro Asp Ser Leu Pro Glu Val Ser Ile Val Phe 
145                 150                 155                 160 


Ile Phe Val Asn Glu Ala Leu Ser Val Leu Leu Arg Ser Ile His Ser 
                165                 170                 175     


Ala Met Glu Arg Thr Pro Pro His Leu Leu Lys Glu Ile Ile Leu Val 
            180                 185                 190         


Asp Asp Asn Ser Ser Asn Glu Glu Leu Lys Glu Lys Leu Thr Glu Tyr 
        195                 200                 205             


Val Asp Lys Val Asn Ser Gln Lys Pro Gly Phe Ile Lys Val Val Arg 
    210                 215                 220                 


His Ser Lys Gln Glu Gly Leu Ile Arg Ser Arg Val Ser Gly Trp Arg 
225                 230                 235                 240 


Ala Ala Thr Ala Pro Val Val Ala Leu Phe Asp Ala His Val Glu Phe 
                245                 250                 255     


Asn Val Gly Trp Ala Glu Pro Val Leu Thr Arg Ile Lys Glu Asn Arg 
            260                 265                 270         


Lys Arg Ile Ile Ser Pro Ser Phe Asp Asn Ile Lys Tyr Asp Asn Phe 
        275                 280                 285             


Glu Ile Glu Glu Tyr Pro Leu Ala Ala Gln Gly Phe Asp Trp Glu Leu 
    290                 295                 300                 


Trp Cys Arg Tyr Leu Asn Pro Pro Lys Ala Trp Trp Lys Leu Glu Asn 
305                 310                 315                 320 


Ser Thr Ala Pro Ile Arg Ser Pro Ala Leu Ile Gly Cys Phe Ile Val 
                325                 330                 335     


Asp Arg Gln Tyr Phe Gln Glu Ile Gly Leu Leu Asp Glu Gly Met Glu 
            340                 345                 350         


Val Tyr Gly Gly Glu Asn Val Glu Leu Gly Ile Arg Val Trp Gln Cys 
        355                 360                 365             


Gly Gly Ser Val Glu Val Leu Pro Cys Ser Arg Ile Ala His Ile Glu 
    370                 375                 380                 


Arg Ala His Lys Pro Tyr Thr Glu Asp Leu Thr Ala His Val Arg Arg 
385                 390                 395                 400 


Asn Ala Leu Arg Val Ala Glu Val Trp Met Asp Glu Phe Lys Ser His 
                405                 410                 415     


Val Tyr Met Ala Trp Asn Ile Pro Gln Glu Asp Ser Gly Ile Asp Ile 
            420                 425                 430         


Gly Asp Ile Thr Ala Arg Lys Ala Leu Arg Lys Gln Leu Gln Cys Lys 
        435                 440                 445             


Thr Phe Arg Trp Tyr Leu Val Ser Val Tyr Pro Glu Met Arg Met Tyr 
    450                 455                 460                 


Ser Asp Ile Ile Ala Tyr Gly Val Leu Gln Asn Ser Leu Lys Thr Asp 
465                 470                 475                 480 


Leu Cys Leu Asp Gln Gly Pro Asp Thr Glu Asn Val Pro Ile Met Tyr 
                485                 490                 495     


Ile Cys His Gly Met Thr Pro Gln Asn Val Tyr Tyr Thr Ser Ser Gln 
            500                 505                 510         


Gln Ile His Val Gly Ile Leu Ser Pro Thr Val Asp Asp Asp Asp Asn 
        515                 520                 525             


Arg Cys Leu Val Asp Val Asn Ser Arg Pro Arg Leu Ile Glu Cys Ser 
    530                 535                 540                 


Tyr Ala Lys Ala Lys Arg Met Lys Leu His Trp Gln Phe Ser Gln Gly 
545                 550                 555                 560 


Gly Pro Ile Gln Asn Arg Lys Ser Lys Arg Cys Leu Glu Leu Gln Glu 
                565                 570                 575     


Asn Ser Asp Leu Glu Phe Gly Phe Gln Leu Val Leu Gln Lys Cys Ser 
            580                 585                 590         


Gly Gln His Trp Ser Ile Thr Asn Val Leu Arg Ser Leu Ala Ser 
        595                 600                 605         


<210>  20
<211>  601
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Arg Lys Gln Lys Arg Phe Leu Gln Met Thr Leu Leu Phe Thr 
1               5                   10                  15      


Val Ala Leu Ile Phe Leu Pro Asn Val Gly Leu Trp Ser Leu Tyr Lys 
            20                  25                  30          


Asp Lys His Leu Val Lys Ser Ala Glu Pro Gly Glu Gln Gln Thr Phe 
        35                  40                  45              


Pro Leu Gly Leu Gly Asp Gly Gln Phe Tyr Ser Trp Thr Asp Gly Leu 
    50                  55                  60                  


Arg Arg Lys Asp Trp His Asp Tyr Glu Ser Ile Gln Lys Glu Ala Met 
65                  70                  75                  80  


Arg Ser Gly Lys Gly Glu His Gly Lys Pro Tyr Pro Leu Thr Glu Glu 
                85                  90                  95      


Asp His Asp Asp Ser Ala Tyr Arg Glu Asn Gly Phe Asn Ile Phe Val 
            100                 105                 110         


Ser Asn Asn Ile Ala Leu Glu Arg Ser Leu Pro Asp Ile Arg His Ala 
        115                 120                 125             


Asn Cys Lys His Lys Met Tyr Leu Glu Arg Leu Pro Asn Thr Ser Ile 
    130                 135                 140                 


Ile Ile Pro Phe His Asn Glu Gly Trp Thr Ser Leu Leu Arg Thr Ile 
145                 150                 155                 160 


His Ser Ile Ile Asn Arg Thr Pro Gly Ser Leu Ile Ala Glu Ile Ile 
                165                 170                 175     


Leu Val Asp Asp Phe Ser Glu Arg Glu His Leu Lys Asp Lys Leu Glu 
            180                 185                 190         


Glu Tyr Met Ala Arg Phe Ser Lys Val Arg Ile Val Arg Thr Lys Lys 
        195                 200                 205             


Arg Glu Gly Leu Ile Arg Thr Arg Leu Leu Gly Ala Ser Met Ala Arg 
    210                 215                 220                 


Gly Glu Val Leu Thr Phe Leu Asp Ser His Cys Glu Val Asn Val Asn 
225                 230                 235                 240 


Trp Leu Pro Pro Leu Leu Asn Gln Ile Ala Leu Asn His Lys Thr Ile 
                245                 250                 255     


Val Cys Pro Met Ile Asp Val Ile Asp His Asn His Phe Gly Tyr Glu 
            260                 265                 270         


Ala Gln Ala Gly Asp Ala Met Arg Gly Ala Phe Asp Trp Glu Met Tyr 
        275                 280                 285             


Tyr Lys Arg Ile Pro Ile Pro Pro Glu Leu Gln Arg Ala Asp Pro Ser 
    290                 295                 300                 


Asp Pro Phe Glu Ser Pro Val Met Ala Gly Gly Leu Phe Ala Val Asp 
305                 310                 315                 320 


Arg Lys Trp Phe Trp Glu Leu Gly Gly Tyr Asp Pro Gly Leu Glu Ile 
                325                 330                 335     


Trp Gly Gly Glu Gln Tyr Glu Ile Ser Phe Lys Val Trp Met Cys Gly 
            340                 345                 350         


Gly Glu Met Phe Asp Val Pro Cys Ser Arg Val Gly His Ile Tyr Arg 
        355                 360                 365             


Lys Tyr Val Pro Tyr Lys Val Pro Ser Gly Thr Ser Leu Ala Arg Asn 
    370                 375                 380                 


Leu Lys Arg Val Ala Glu Thr Trp Met Asp Glu Phe Ala Glu Tyr Ile 
385                 390                 395                 400 


Tyr Gln Arg Arg Pro Glu Tyr Arg His Leu Ser Thr Gly Asp Ile Ser 
                405                 410                 415     


Ala Gln Lys Glu Leu Arg Lys Gln Leu Lys Cys Lys Asp Phe Lys Trp 
            420                 425                 430         


Phe Met Ala Ala Val Ala Trp Asp Val Pro Lys Tyr Tyr Pro Pro Val 
        435                 440                 445             


Glu Pro Pro Pro Ala Ala Trp Gly Glu Ile Arg Asn Val Ala Ala Asn 
    450                 455                 460                 


Leu Cys Val Asp Ser Lys His Gly Ala Thr Gly Thr Glu Leu Arg Leu 
465                 470                 475                 480 


Asp Ile Cys Val Lys Asp Gly Ser Glu Arg Thr Trp Ser His Glu Gln 
                485                 490                 495     


Leu Phe Thr Phe Gly Trp Arg Glu Asp Ile Arg Pro Gly Glu Pro Leu 
            500                 505                 510         


His Thr Arg Lys Phe Cys Phe Asp Ala Ile Ser His Asn Ser Pro Val 
        515                 520                 525             


Thr Leu Tyr Asp Cys His Gly Met Lys Gly Asn Gln Leu Trp Gly Tyr 
    530                 535                 540                 


Arg Lys Asp Arg Thr Leu Phe His Pro Val Ser Asn Ser Cys Met Asp 
545                 550                 555                 560 


Cys Asn Pro Ala Glu Lys Lys Ile Phe Met Ala Arg Cys Asp Pro Leu 
                565                 570                 575     


Ser Glu Thr Gln Gln Trp Ile Phe Glu His Ile Asn Met Thr Val Leu 
            580                 585                 590         


Glu Lys Phe Asn His His Ala Asn Ser 
        595                 600     


<210>  21
<211>  271
<212>  PRT
<213>  Campylobacter jejuni

<400>  21

Phe Lys Ile Ser Ile Ile Leu Pro Thr Tyr Asn Val Glu Gln Tyr Ile 
1               5                   10                  15      


Ala Arg Ala Ile Glu Ser Cys Ile Asn Gln Thr Phe Lys Asp Ile Glu 
            20                  25                  30          


Ile Ile Val Val Asp Asp Cys Gly Asn Asp Asn Ser Ile Asn Ile Ala 
        35                  40                  45              


Lys Glu Tyr Ser Lys Lys Asp Lys Arg Ile Lys Ile Ile His Asn Glu 
    50                  55                  60                  


Lys Asn Leu Gly Leu Leu Arg Ala Arg Tyr Glu Gly Val Lys Val Ala 
65                  70                  75                  80  


Asn Ser Pro Tyr Ile Met Phe Leu Asp Pro Asp Asp Tyr Leu Glu Leu 
                85                  90                  95      


Asn Ala Cys Glu Glu Cys Ile Lys Ile Leu Asp Glu Gln Asp Glu Val 
            100                 105                 110         


Asp Leu Val Phe Phe Asn Ala Ile Val Glu Ser Asn Val Ile Ser Tyr 
        115                 120                 125             


Lys Lys Phe Asp Phe Asn Ser Gly Phe Tyr Ser Lys Lys Glu Phe Val 
    130                 135                 140                 


Lys Lys Ile Ile Ala Lys Lys Asn Leu Tyr Trp Thr Met Trp Gly Lys 
145                 150                 155                 160 


Leu Ile Arg Lys Lys Leu Tyr Leu Glu Ala Phe Ala Ser Leu Arg Leu 
                165                 170                 175     


Glu Lys Asp Val Lys Ile Asn Met Ala Glu Asp Val Leu Leu Tyr Tyr 
            180                 185                 190         


Pro Met Leu Ser Gln Ala Gln Lys Ile Ala Tyr Met Asn Cys Asn Leu 
        195                 200                 205             


Tyr His Tyr Val Pro Asn Asn Asn Ser Ile Cys Asn Thr Lys Asn Glu 
    210                 215                 220                 


Val Leu Val Lys Asn Asn Ile Gln Glu Leu Gln Leu Val Leu Asn Tyr 
225                 230                 235                 240 


Leu Arg Gln Asn Tyr Ile Leu Asn Lys Tyr Cys Ser Val Leu Tyr Val 
                245                 250                 255     


Leu Ile Lys Tyr Leu Leu Tyr Ile Gln Ile Tyr Lys Ile Lys Pro 
            260                 265                 270     


<210>  22
<211>  388
<212>  PRT
<213>  Drosophila melanogaster

<400>  22

Met Thr Ala Asn Ser Leu Leu Gly Arg Ser Ile Leu Asn Glu Gly Arg 
1               5                   10                  15      


Ser Asn Lys Arg Ser Phe Val Ser Leu Ile Val Gly Leu Ile Val Gly 
            20                  25                  30          


Phe Cys Leu Ala Glu Leu Phe Val Tyr Ser Thr Pro Glu Arg Ser Glu 
        35                  40                  45              


Phe Met Pro Tyr Asp Gly His Arg His Gly Asp Val Asn Asp Ala His 
    50                  55                  60                  


His Ser His Asp Met Met Glu Met Ser Gly Pro Glu Gln Asp Val Gly 
65                  70                  75                  80  


Gly His Glu His Val His Glu Asn Ser Thr Ile Ala Glu Arg Leu Tyr 
                85                  90                  95      


Ser Glu Val Arg Val Leu Cys Trp Ile Met Thr Asn Pro Ser Asn His 
            100                 105                 110         


Gln Lys Lys Ala Arg His Val Lys Arg Thr Trp Gly Lys Arg Cys Asn 
        115                 120                 125             


Lys Leu Ile Phe Met Ser Ser Ala Lys Asp Asp Glu Leu Asp Ala Val 
    130                 135                 140                 


Ala Leu Pro Val Gly Glu Gly Arg Asn Asn Leu Trp Gly Lys Thr Lys 
145                 150                 155                 160 


Glu Ala Tyr Lys Tyr Ile Tyr Glu His His Ile Asn Asp Ala Asp Trp 
                165                 170                 175     


Phe Leu Lys Ala Asp Asp Asp Thr Tyr Thr Ile Val Glu Asn Met Arg 
            180                 185                 190         


Tyr Met Leu Tyr Pro Tyr Ser Pro Glu Thr Pro Val Tyr Phe Gly Cys 
        195                 200                 205             


Lys Phe Lys Pro Tyr Val Lys Gln Gly Tyr Met Ser Gly Gly Ala Gly 
    210                 215                 220                 


Tyr Val Leu Ser Arg Glu Ala Val Arg Arg Phe Val Val Glu Ala Leu 
225                 230                 235                 240 


Pro Asn Pro Lys Leu Cys Lys Ser Asp Asn Ser Gly Ala Glu Asp Val 
                245                 250                 255     


Glu Ile Gly Lys Cys Leu Gln Asn Val Asn Val Leu Ala Gly Asp Ser 
            260                 265                 270         


Arg Asp Ser Asn Gly Arg Gly Arg Phe Phe Pro Phe Val Pro Glu His 
        275                 280                 285             


His Leu Ile Pro Ser His Thr Asp Lys Lys Phe Trp Tyr Trp Gln Tyr 
    290                 295                 300                 


Ile Phe Tyr Lys Thr Asp Glu Gly Leu Asp Cys Cys Ser Asp Asn Ala 
305                 310                 315                 320 


Ile Ser Phe His Tyr Val Ser Pro Asn Gln Met Tyr Val Leu Asp Tyr 
                325                 330                 335     


Leu Ile Tyr His Leu Arg Pro Tyr Gly Ile Ile Asn Thr Pro Asp Ala 
            340                 345                 350         


Leu Pro Asn Lys Leu Ala Val Gly Glu Leu Met Pro Glu Ile Lys Glu 
        355                 360                 365             


Gln Ala Thr Glu Ser Thr Ser Asp Gly Val Ser Lys Arg Ser Ala Glu 
    370                 375                 380                 


Thr Lys Thr Gln 
385             


<210>  23
<211>  343
<212>  PRT
<213>  Drosophila melanogaster

<400>  23

Met Ser Glu Phe Met Pro Tyr Asp Gly His Arg His Gly Asp Val Asn 
1               5                   10                  15      


Asp Ala His His Ser His Asp Met Met Glu Met Ser Gly Pro Glu Gln 
            20                  25                  30          


Asp Val Gly Gly His Glu His Val His Glu Asn Ser Thr Ile Ala Glu 
        35                  40                  45              


Arg Leu Tyr Ser Glu Val Arg Val Leu Cys Trp Ile Met Thr Asn Pro 
    50                  55                  60                  


Ser Asn His Gln Lys Lys Ala Arg His Val Lys Arg Thr Trp Gly Lys 
65                  70                  75                  80  


Arg Cys Asn Lys Leu Ile Phe Met Ser Ser Ala Lys Asp Asp Glu Leu 
                85                  90                  95      


Asp Ala Val Ala Leu Pro Val Gly Glu Gly Arg Asn Asn Leu Trp Gly 
            100                 105                 110         


Lys Thr Lys Glu Ala Tyr Lys Tyr Ile Tyr Glu His His Ile Asn Asp 
        115                 120                 125             


Ala Asp Trp Phe Leu Lys Ala Asp Asp Asp Thr Tyr Thr Ile Val Glu 
    130                 135                 140                 


Asn Met Arg Tyr Met Leu Tyr Pro Tyr Ser Pro Glu Thr Pro Val Tyr 
145                 150                 155                 160 


Phe Gly Cys Lys Phe Lys Pro Tyr Val Lys Gln Gly Tyr Met Ser Gly 
                165                 170                 175     


Gly Ala Gly Tyr Val Leu Ser Arg Glu Ala Val Arg Arg Phe Val Val 
            180                 185                 190         


Glu Ala Leu Pro Asn Pro Lys Leu Cys Lys Ser Asp Asn Ser Gly Ala 
        195                 200                 205             


Glu Asp Val Glu Ile Gly Lys Cys Leu Gln Asn Val Asn Val Leu Ala 
    210                 215                 220                 


Gly Asp Ser Arg Asp Ser Asn Gly Arg Gly Arg Phe Phe Pro Phe Val 
225                 230                 235                 240 


Pro Glu His His Leu Ile Pro Ser His Thr Asp Lys Lys Phe Trp Tyr 
                245                 250                 255     


Trp Gln Tyr Ile Phe Tyr Lys Thr Asp Glu Gly Leu Asp Cys Cys Ser 
            260                 265                 270         


Asp Asn Ala Ile Ser Phe His Tyr Val Ser Pro Asn Gln Met Tyr Val 
        275                 280                 285             


Leu Asp Tyr Leu Ile Tyr His Leu Arg Pro Tyr Gly Ile Ile Asn Thr 
    290                 295                 300                 


Pro Asp Ala Leu Pro Asn Lys Leu Ala Val Gly Glu Leu Met Pro Glu 
305                 310                 315                 320 


Ile Lys Glu Gln Ala Thr Glu Ser Thr Ser Asp Gly Val Ser Lys Arg 
                325                 330                 335     


Ser Ala Glu Thr Lys Thr Gln 
            340             


<210>  24
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Arg Ser Gly Thr Asp Pro Gln Gln Arg Gln Gln Ala Ser Glu 
1               5                   10                  15      


Ala Asp Ala Ala Ala Ala Thr Phe Arg Ala Asn Asp His Gln His Ile 
            20                  25                  30          


Arg Tyr Asn Pro Leu Gln Asp Glu Trp Val Leu Val Ser Ala His Arg 
        35                  40                  45              


Met Lys Arg Pro Trp Gln Gly Gln Val Glu Pro Gln Leu Leu Lys Thr 
    50                  55                  60                  


Val Pro Arg His Asp Pro Leu Asn Pro Leu Cys Pro Gly Ala Ile Arg 
65                  70                  75                  80  


Ala Asn Gly Glu Val Asn Pro Gln Tyr Asp Ser Thr Phe Leu Phe Asp 
                85                  90                  95      


Asn Asp Phe Pro Ala Leu Gln Pro Asp Ala Pro Ser Pro Gly Pro Ser 
            100                 105                 110         


Asp His Pro Leu Phe Gln Ala Lys Ser Ala Arg Gly Val Cys Lys Val 
        115                 120                 125             


Met Cys Phe His Pro Trp Ser Asp Val Thr Leu Pro Leu Met Ser Val 
    130                 135                 140                 


Pro Glu Ile Arg Ala Val Val Asp Ala Trp Ala Ser Val Thr Glu Glu 
145                 150                 155                 160 


Leu Gly Ala Gln Tyr Pro Trp Val Gln Ile Phe Glu Asn Lys Gly Ala 
                165                 170                 175     


Met Met Gly Cys Ser Asn Pro His Pro His Cys Gln Val Trp Ala Ser 
            180                 185                 190         


Ser Phe Leu Pro Asp Ile Ala Gln Arg Glu Glu Arg Ser Gln Gln Ala 
        195                 200                 205             


Tyr Lys Ser Gln His Gly Glu Pro Leu Leu Met Glu Tyr Ser Arg Gln 
    210                 215                 220                 


Glu Leu Leu Arg Lys Glu Arg Leu Val Leu Thr Ser Glu His Trp Leu 
225                 230                 235                 240 


Val Leu Val Pro Phe Trp Ala Thr Trp Pro Tyr Gln Thr Leu Leu Leu 
                245                 250                 255     


Pro Arg Arg His Val Arg Arg Leu Pro Glu Leu Thr Pro Ala Glu Arg 
            260                 265                 270         


Asp Asp Leu Ala Ser Ile Met Lys Lys Leu Leu Thr Lys Tyr Asp Asn 
        275                 280                 285             


Leu Phe Glu Thr Ser Phe Pro Tyr Ser Met Gly Trp His Gly Ala Pro 
    290                 295                 300                 


Thr Gly Ser Glu Ala Gly Ala Asn Trp Asn His Trp Gln Leu His Ala 
305                 310                 315                 320 


His Tyr Tyr Pro Pro Leu Leu Arg Ser Ala Thr Val Arg Lys Phe Met 
                325                 330                 335     


Val Gly Tyr Glu Met Leu Ala Gln Ala Gln Arg Asp Leu Thr Pro Glu 
            340                 345                 350         


Gln Ala Ala Glu Arg Leu Arg Ala Leu Pro Glu Val His Tyr His Leu 
        355                 360                 365             


Gly Gln Lys Asp Arg Glu Thr Ala Thr Ile Ala 
    370                 375                 


<210>  25
<211>  328
<212>  PRT
<213>  Campylobacter jejuni

<400>  25

Met Lys Ile Leu Ile Ser Gly Gly Ala Gly Tyr Ile Gly Ser His Thr 
1               5                   10                  15      


Leu Arg Gln Phe Leu Lys Thr Asp His Glu Ile Cys Val Leu Asp Asn 
            20                  25                  30          


Leu Ser Lys Gly Ser Lys Ile Ala Ile Glu Asp Leu Gln Lys Thr Arg 
        35                  40                  45              


Ala Phe Lys Phe Phe Glu Gln Asp Leu Ser Asp Phe Gln Gly Val Lys 
    50                  55                  60                  


Ala Leu Phe Glu Arg Glu Lys Phe Asp Ala Ile Val His Phe Ala Ala 
65                  70                  75                  80  


Ser Ile Glu Val Phe Glu Ser Met Gln Asn Pro Leu Lys Tyr Tyr Met 
                85                  90                  95      


Asn Asn Thr Val Asn Thr Thr Asn Leu Ile Glu Thr Cys Leu Gln Thr 
            100                 105                 110         


Gly Val Asn Lys Phe Ile Phe Ser Ser Thr Ala Ala Thr Tyr Gly Glu 
        115                 120                 125             


Pro Gln Thr Pro Val Val Ser Glu Thr Ser Pro Leu Ala Pro Ile Asn 
    130                 135                 140                 


Pro Tyr Gly Arg Ser Lys Leu Met Ser Glu Glu Val Leu Arg Asp Ala 
145                 150                 155                 160 


Ser Met Ala Asn Pro Glu Phe Lys His Cys Ile Leu Arg Tyr Phe Asn 
                165                 170                 175     


Val Ala Gly Ala Cys Met Asp Tyr Thr Leu Gly Gln Arg Tyr Pro Lys 
            180                 185                 190         


Ala Thr Leu Leu Ile Lys Val Ala Ala Glu Cys Ala Ala Gly Lys Arg 
        195                 200                 205             


Asp Lys Leu Phe Ile Phe Gly Asp Asp Tyr Asp Thr Lys Asp Gly Thr 
    210                 215                 220                 


Cys Ile Arg Asp Phe Ile His Val Asp Asp Ile Ser Ser Ala His Leu 
225                 230                 235                 240 


Ala Ala Leu Asp Tyr Leu Lys Glu Asn Glu Ser Asn Val Phe Asn Val 
                245                 250                 255     


Gly Tyr Gly His Gly Phe Ser Val Lys Glu Val Ile Glu Ala Met Lys 
            260                 265                 270         


Lys Val Ser Gly Val Asp Phe Lys Val Glu Leu Ala Pro Arg Arg Ala 
        275                 280                 285             


Gly Asp Pro Ser Val Leu Ile Ser Asp Ala Ser Lys Ile Arg Asn Leu 
    290                 295                 300                 


Thr Ser Trp Gln Pro Lys Tyr Asp Asp Leu Glu Leu Ile Cys Lys Ser 
305                 310                 315                 320 


Ala Phe Asp Trp Glu Lys Gln Cys 
                325             


<210>  26
<211>  328
<212>  PRT
<213>  Campylobacter jejuni

<400>  26

Met Lys Ile Leu Ile Ser Gly Gly Ala Gly Tyr Ile Gly Ser His Thr 
1               5                   10                  15      


Leu Arg Gln Phe Leu Lys Thr Asp His Glu Ile Cys Val Leu Asp Asn 
            20                  25                  30          


Leu Ser Lys Gly Ser Lys Ile Ala Ile Glu Asp Leu Gln Lys Thr Arg 
        35                  40                  45              


Ala Phe Lys Phe Phe Glu Gln Asp Leu Ser Asp Phe Gln Gly Val Lys 
    50                  55                  60                  


Ala Leu Phe Glu Arg Glu Lys Phe Asp Ala Ile Val His Phe Ala Ala 
65                  70                  75                  80  


Ser Ile Glu Val Phe Glu Ser Met Gln Asn Pro Leu Lys Tyr Tyr Met 
                85                  90                  95      


Asn Asn Thr Val Asn Thr Thr Asn Leu Ile Glu Thr Cys Leu Gln Thr 
            100                 105                 110         


Gly Val Asn Lys Phe Ile Phe Ser Ser Thr Ala Ala Thr Tyr Gly Glu 
        115                 120                 125             


Pro Gln Thr Pro Val Val Ser Glu Thr Ser Pro Leu Ala Pro Ile Asn 
    130                 135                 140                 


Pro Tyr Gly Arg Ser Lys Leu Met Ser Glu Glu Val Leu Arg Asp Ala 
145                 150                 155                 160 


Ser Met Ala Asn Pro Glu Phe Lys His Cys Ile Leu Arg Tyr Phe Asn 
                165                 170                 175     


Val Ala Gly Ala Cys Met Asp Tyr Thr Leu Gly Gln Arg Tyr Pro Lys 
            180                 185                 190         


Ala Thr Leu Leu Ile Lys Val Ala Ala Glu Cys Ala Ala Gly Lys Arg 
        195                 200                 205             


Asp Lys Leu Phe Ile Phe Gly Asp Asp Tyr Asp Thr Lys Asp Gly Thr 
    210                 215                 220                 


Cys Ile Arg Asp Phe Ile His Val Asp Asp Ile Ser Ser Ala His Leu 
225                 230                 235                 240 


Ala Ala Leu Asp Tyr Leu Lys Glu Asn Glu Ser Asn Val Phe Asn Val 
                245                 250                 255     


Gly Tyr Gly His Gly Phe Ser Val Lys Glu Val Ile Glu Ala Met Lys 
            260                 265                 270         


Lys Val Ser Gly Val Asp Phe Lys Val Glu Leu Ala Pro Arg Arg Ala 
        275                 280                 285             


Gly Asp Pro Ser Val Leu Ile Ser Asp Ala Ser Lys Ile Arg Asn Leu 
    290                 295                 300                 


Thr Ser Trp Gln Pro Lys Tyr Asp Asp Leu Glu Leu Ile Cys Lys Ser 
305                 310                 315                 320 


Ala Phe Asp Trp Glu Lys Gln Cys 
                325             


<210>  27
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Glu Lys Val Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser 
1               5                   10                  15      


His Thr Val Leu Glu Leu Leu Glu Ala Gly Tyr Leu Pro Val Val Ile 
            20                  25                  30          


Asp Asn Phe His Asn Ala Phe Arg Gly Gly Gly Ser Leu Pro Glu Ser 
        35                  40                  45              


Leu Arg Arg Val Gln Glu Leu Thr Gly Arg Ser Val Glu Phe Glu Glu 
    50                  55                  60                  


Met Asp Ile Leu Asp Gln Gly Ala Leu Gln Arg Leu Phe Lys Lys Tyr 
65                  70                  75                  80  


Ser Phe Met Ala Val Ile His Phe Ala Gly Leu Lys Ala Val Gly Glu 
                85                  90                  95      


Ser Val Gln Lys Pro Leu Asp Tyr Tyr Arg Val Asn Leu Thr Gly Thr 
            100                 105                 110         


Ile Gln Leu Leu Glu Ile Met Lys Ala His Gly Val Lys Asn Leu Val 
        115                 120                 125             


Phe Ser Ser Ser Ala Thr Val Tyr Gly Asn Pro Gln Tyr Leu Pro Leu 
    130                 135                 140                 


Asp Glu Ala His Pro Thr Gly Gly Cys Thr Asn Pro Tyr Gly Lys Ser 
145                 150                 155                 160 


Lys Phe Phe Ile Glu Glu Met Ile Arg Asp Leu Cys Gln Ala Asp Lys 
                165                 170                 175     


Thr Trp Asn Ala Val Leu Leu Arg Tyr Phe Asn Pro Thr Gly Ala His 
            180                 185                 190         


Ala Ser Gly Cys Ile Gly Glu Asp Pro Gln Gly Ile Pro Asn Asn Leu 
        195                 200                 205             


Met Pro Tyr Val Ser Gln Val Ala Ile Gly Arg Arg Glu Ala Leu Asn 
    210                 215                 220                 


Val Phe Gly Asn Asp Tyr Asp Thr Glu Asp Gly Thr Gly Val Arg Asp 
225                 230                 235                 240 


Tyr Ile His Val Val Asp Leu Ala Lys Gly His Ile Ala Ala Leu Arg 
                245                 250                 255     


Lys Leu Lys Glu Gln Cys Gly Cys Arg Ile Tyr Asn Leu Gly Thr Gly 
            260                 265                 270         


Thr Gly Tyr Ser Val Leu Gln Met Val Gln Ala Met Glu Lys Ala Ser 
        275                 280                 285             


Gly Lys Lys Ile Pro Tyr Lys Val Val Ala Arg Arg Glu Gly Asp Val 
    290                 295                 300                 


Ala Ala Cys Tyr Ala Asn Pro Ser Leu Ala Gln Glu Glu Leu Gly Trp 
305                 310                 315                 320 


Thr Ala Ala Leu Gly Leu Asp Arg Met Cys Glu Asp Leu Trp Arg Trp 
                325                 330                 335     


Gln Lys Gln Asn Pro Ser Gly Phe Gly Thr Gln Ala 
            340                 345             


<210>  28
<211>  347
<212>  PRT
<213>  Mus musculus

<400>  28

Met Glu Lys Val Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser His 
1               5                   10                  15      


Thr Val Leu Glu Leu Leu Glu Ala Gly Tyr Ser Pro Val Val Ile Asp 
            20                  25                  30          


Asn Phe His Asn Ala Ile Arg Gly Glu Asp Ser Met Pro Glu Ser Leu 
        35                  40                  45              


Arg Arg Val Gln Glu Leu Thr Gly Arg Ser Val Glu Phe Glu Glu Met 
    50                  55                  60                  


Asp Ile Leu Asp Gln Ala Ala Leu Gln His Leu Phe Lys Lys His Ser 
65                  70                  75                  80  


Phe Lys Ala Val Ile His Phe Ala Gly Leu Lys Ala Val Gly Glu Ser 
                85                  90                  95      


Val Gln Lys Pro Leu Asp Tyr Tyr Arg Val Asn Leu Thr Gly Thr Ile 
            100                 105                 110         


Gln Leu Leu Glu Ile Met Arg Ala His Gly Val Lys Asn Leu Val Phe 
        115                 120                 125             


Ser Ser Ser Ala Thr Val Tyr Gly Asn Pro Gln Tyr Leu Pro Leu Asp 
    130                 135                 140                 


Glu Ala His Pro Thr Gly Gly Cys Thr Asn Pro Tyr Gly Lys Ser Lys 
145                 150                 155                 160 


Phe Phe Ile Glu Glu Met Ile Arg Asp Leu Cys Arg Ala Asp Thr Ala 
                165                 170                 175     


Trp Asn Ala Val Leu Leu Arg Tyr Phe Asn Pro Ile Gly Ala His Ala 
            180                 185                 190         


Ser Gly Arg Ile Gly Glu Asp Pro Gln Gly Ile Pro Asn Asn Leu Met 
        195                 200                 205             


Pro Tyr Val Ser Gln Val Ala Ile Gly Arg Arg Glu Ala Leu Asn Val 
    210                 215                 220                 


Phe Gly Asp Asp Tyr Ala Thr Glu Asp Gly Thr Gly Val Arg Asp Tyr 
225                 230                 235                 240 


Ile His Val Val Asp Leu Ala Lys Gly His Ile Ala Ala Leu Lys Lys 
                245                 250                 255     


Leu Lys Glu Gln Cys Gly Cys Arg Thr Tyr Asn Leu Gly Thr Gly Thr 
            260                 265                 270         


Gly Tyr Ser Val Leu Gln Met Val Gln Ala Met Glu Lys Ala Ser Gly 
        275                 280                 285             


Lys Lys Ile Pro Tyr Lys Val Val Ala Arg Arg Glu Gly Asp Val Ala 
    290                 295                 300                 


Ala Cys Tyr Ala Asn Pro Ser Leu Ala His Glu Glu Leu Gly Trp Thr 
305                 310                 315                 320 


Ala Ala Leu Gly Leu Asp Arg Met Cys Glu Asp Leu Trp Arg Trp Gln 
                325                 330                 335     


Lys Gln Asn Pro Ser Gly Phe Gly Ala Gln Ala 
            340                 345         


<210>  29
<211>  338
<212>  PRT
<213>  Escherichia coli

<400>  29

Met Arg Val Leu Val Thr Gly Gly Ser Gly Tyr Ile Gly Ser His Thr 
1               5                   10                  15      


Cys Val Gln Leu Leu Gln Asn Gly His Asp Val Ile Ile Leu Asp Asn 
            20                  25                  30          


Leu Cys Asn Ser Lys Arg Ser Val Leu Pro Val Ile Glu Arg Leu Gly 
        35                  40                  45              


Gly Lys His Pro Thr Phe Val Glu Gly Asp Ile Arg Asn Glu Ala Leu 
    50                  55                  60                  


Met Thr Glu Ile Leu His Asp His Ala Ile Asp Thr Val Ile His Phe 
65                  70                  75                  80  


Ala Gly Leu Lys Ala Val Gly Glu Ser Val Gln Lys Pro Leu Glu Tyr 
                85                  90                  95      


Tyr Asp Asn Asn Val Asn Gly Thr Leu Arg Leu Ile Ser Ala Met Arg 
            100                 105                 110         


Ala Ala Asn Val Lys Asn Phe Ile Phe Ser Ser Ser Ala Thr Val Tyr 
        115                 120                 125             


Gly Asp Gln Pro Lys Ile Pro Tyr Val Glu Ser Phe Pro Thr Gly Thr 
    130                 135                 140                 


Pro Gln Ser Pro Tyr Gly Lys Ser Lys Leu Met Val Glu Gln Ile Leu 
145                 150                 155                 160 


Thr Asp Leu Gln Lys Ala Gln Pro Asp Trp Ser Ile Ala Leu Leu Arg 
                165                 170                 175     


Tyr Phe Asn Pro Val Gly Ala His Pro Ser Gly Asp Met Gly Glu Asp 
            180                 185                 190         


Pro Gln Gly Ile Pro Asn Asn Leu Met Pro Tyr Ile Ala Gln Val Ala 
        195                 200                 205             


Val Gly Arg Arg Asp Ser Leu Ala Ile Phe Gly Asn Asp Tyr Pro Thr 
    210                 215                 220                 


Glu Asp Gly Thr Gly Val Arg Asp Tyr Ile His Val Met Asp Leu Ala 
225                 230                 235                 240 


Asp Gly His Val Val Ala Met Glu Lys Leu Ala Asn Lys Pro Gly Val 
                245                 250                 255     


His Ile Tyr Asn Leu Gly Ala Gly Val Gly Asn Ser Val Leu Asp Val 
            260                 265                 270         


Val Asn Ala Phe Ser Lys Ala Cys Gly Lys Pro Val Asn Tyr His Phe 
        275                 280                 285             


Ala Pro Arg Arg Glu Gly Asp Leu Pro Ala Tyr Trp Ala Asp Ala Ser 
    290                 295                 300                 


Lys Ala Asp Arg Glu Leu Asn Trp Arg Val Thr Arg Thr Leu Asp Glu 
305                 310                 315                 320 


Met Ala Gln Asp Thr Trp His Trp Gln Ser Arg His Pro Gln Gly Tyr 
                325                 330                 335     


Pro Asp 
        


<210>  30
<211>  216
<212>  PRT
<213>  Escherichia coli

<400>  30

Asp Asp Ala Ala Ile Gln Gln Thr Leu Ala Lys Met Gly Ile Lys Ser 
1               5                   10                  15      


Ser Asp Ile Gln Pro Ala Pro Val Ala Gly Met Lys Thr Val Leu Thr 
            20                  25                  30          


Asn Ser Gly Val Leu Tyr Ile Thr Asp Asp Gly Lys His Ile Ile Gln 
        35                  40                  45              


Gly Pro Met Tyr Asp Val Ser Gly Thr Ala Pro Val Asn Val Thr Asn 
    50                  55                  60                  


Lys Met Leu Leu Lys Gln Leu Asn Ala Leu Glu Lys Glu Met Ile Val 
65                  70                  75                  80  


Tyr Lys Ala Pro Gln Glu Lys His Val Ile Thr Val Phe Thr Asp Ile 
                85                  90                  95      


Thr Cys Gly Tyr Cys His Lys Leu His Glu Gln Met Ala Asp Tyr Asn 
            100                 105                 110         


Ala Leu Gly Ile Thr Val Arg Tyr Leu Ala Phe Pro Arg Gln Gly Leu 
        115                 120                 125             


Asp Ser Asp Ala Glu Lys Glu Met Lys Ala Ile Trp Cys Ala Lys Asp 
    130                 135                 140                 


Lys Asn Lys Ala Phe Asp Asp Val Met Ala Gly Lys Ser Val Ala Pro 
145                 150                 155                 160 


Ala Ser Cys Asp Val Asp Ile Ala Asp His Tyr Ala Leu Gly Val Gln 
                165                 170                 175     


Leu Gly Val Ser Gly Thr Pro Ala Val Val Leu Ser Asn Gly Thr Leu 
            180                 185                 190         


Val Pro Gly Tyr Gln Pro Pro Lys Glu Met Lys Glu Phe Leu Asp Glu 
        195                 200                 205             


His Gln Lys Met Thr Ser Gly Lys 
    210                 215     


<210>  31
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Arg Ala Gly Pro Ala Trp Leu Leu Leu Ala Ile Trp Val Val 
1               5                   10                  15      


Leu Pro Ser Trp Leu Ser Ser Ala Lys Val Ser Ser Leu Ile Glu Arg 
            20                  25                  30          


Ile Ser Asp Pro Lys Asp Leu Lys Lys Leu Leu Arg Thr Arg Asn Asn 
        35                  40                  45              


Val Leu Val Leu Tyr Ser Lys Ser Glu Val Ala Ala Glu Asn His Leu 
    50                  55                  60                  


Arg Leu Leu Ser Thr Val Ala Gln Ala Val Lys Gly Gln Gly Thr Ile 
65                  70                  75                  80  


Cys Trp Val Asp Cys Gly Asp Ala Glu Ser Arg Lys Leu Cys Lys Lys 
                85                  90                  95      


Met Lys Val Asp Leu Ser Pro Lys Asp Lys Lys Val Glu Leu Phe His 
            100                 105                 110         


Tyr Gln Asp Gly Ala Phe His Thr Glu Tyr Asn Arg Ala Val Thr Phe 
        115                 120                 125             


Lys Ser Ile Val Ala Phe Leu Lys Asp Pro Lys Gly Pro Pro Leu Trp 
    130                 135                 140                 


Glu Glu Asp Pro Gly Ala Lys Asp Val Val His Leu Asp Ser Glu Lys 
145                 150                 155                 160 


Asp Phe Arg Arg Leu Leu Lys Lys Glu Glu Lys Pro Leu Leu Ile Met 
                165                 170                 175     


Phe Tyr Ala Pro Trp Cys Ser Met Cys Lys Arg Met Met Pro His Phe 
            180                 185                 190         


Gln Lys Ala Ala Thr Gln Leu Arg Gly His Ala Val Leu Ala Gly Met 
        195                 200                 205             


Asn Val Tyr Ser Ser Glu Phe Glu Asn Ile Lys Glu Glu Tyr Ser Val 
    210                 215                 220                 


Arg Gly Phe Pro Thr Ile Cys Tyr Phe Glu Lys Gly Arg Phe Leu Phe 
225                 230                 235                 240 


Gln Tyr Asp Asn Tyr Gly Ser Thr Ala Glu Asp Ile Val Glu Trp Leu 
                245                 250                 255     


Lys Asn Pro Gln Pro Pro Gln Pro Gln Val Pro Glu Thr Pro Trp Ala 
            260                 265                 270         


Asp Glu Gly Gly Ser Val Tyr His Leu Thr Asp Glu Asp Phe Asp Gln 
        275                 280                 285             


Phe Val Lys Glu His Ser Ser Val Leu Val Met Phe His Ala Pro Trp 
    290                 295                 300                 


Cys Gly His Cys Lys Lys Met Lys Pro Glu Phe Glu Lys Ala Ala Glu 
305                 310                 315                 320 


Ala Leu His Gly Glu Ala Asp Ser Ser Gly Val Leu Ala Ala Val Asp 
                325                 330                 335     


Ala Thr Val Asn Lys Ala Leu Ala Glu Arg Phe His Ile Ser Glu Phe 
            340                 345                 350         


Pro Thr Leu Lys Tyr Phe Lys Asn Gly Glu Lys Tyr Ala Val Pro Val 
        355                 360                 365             


Leu Arg Thr Lys Lys Lys Phe Leu Glu Trp Met Gln Asn Pro Glu Ala 
    370                 375                 380                 


Pro Pro Pro Pro Glu Pro Thr Trp Glu Glu Gln Gln Thr Ser Val Leu 
385                 390                 395                 400 


His Leu Val Gly Asp Asn Phe Arg Glu Thr Leu Lys Lys Lys Lys His 
                405                 410                 415     


Thr Leu Val Met Phe Tyr Ala Pro Trp Cys Pro His Cys Lys Lys Val 
            420                 425                 430         


Ile Pro His Phe Thr Ala Thr Ala Asp Ala Phe Lys Asp Asp Arg Lys 
        435                 440                 445             


Ile Ala Cys Ala Ala Val Asp Cys Val Lys Asp Lys Asn Gln Asp Leu 
    450                 455                 460                 


Cys Gln Gln Glu Ala Val Lys Gly Tyr Pro Thr Phe His Tyr Tyr His 
465                 470                 475                 480 


Tyr Gly Lys Phe Ala Glu Lys Tyr Asp Ser Asp Arg Thr Glu Leu Gly 
                485                 490                 495     


Phe Thr Asn Tyr Ile Arg Ala Leu Arg Glu Gly Asp His Glu Arg Leu 
            500                 505                 510         


Gly Lys Lys Lys Glu Glu Leu 
        515                 


<210>  32
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  33
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210>  34
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Arg Pro Arg Lys Ala Phe Leu Leu Leu Leu Leu Leu Gly Leu Val 
1               5                   10                  15      


Gln Leu Leu Ala Val Ala Gly Ala Glu Gly Pro Asp Glu Asp Ser Ser 
            20                  25                  30          


Asn Arg Glu Asn Ala Ile Glu Asp Glu Glu Glu Glu Glu Glu Glu Asp 
        35                  40                  45              


Asp Asp Glu Glu Glu Asp Asp Leu Glu Val Lys Glu Glu Asn Gly Val 
    50                  55                  60                  


Leu Val Leu Asn Asp Ala Asn Phe Asp Asn Phe Val Ala Asp Lys Asp 
65                  70                  75                  80  


Thr Val Leu Leu Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
                85                  90                  95      


Phe Ala Pro Glu Tyr Glu Lys Ile Ala Asn Ile Leu Lys Asp Lys Asp 
            100                 105                 110         


Pro Pro Ile Pro Val Ala Lys Ile Asp Ala Thr Ser Ala Ser Val Leu 
        115                 120                 125             


Ala Ser Arg Phe Asp Val Ser Gly Tyr Pro Thr Ile Lys Ile Leu Lys 
    130                 135                 140                 


Lys Gly Gln Ala Val Asp Tyr Glu Gly Ser Arg Thr Gln Glu Glu Ile 
145                 150                 155                 160 


Val Ala Lys Val Arg Glu Val Ser Gln Pro Asp Trp Thr Pro Pro Pro 
                165                 170                 175     


Glu Val Thr Leu Val Leu Thr Lys Glu Asn Phe Asp Glu Val Val Asn 
            180                 185                 190         


Asp Ala Asp Ile Ile Leu Val Glu Phe Tyr Ala Pro Trp Cys Gly His 
        195                 200                 205             


Cys Lys Lys Leu Ala Pro Glu Tyr Glu Lys Ala Ala Lys Glu Leu Ser 
    210                 215                 220                 


Lys Arg Ser Pro Pro Ile Pro Leu Ala Lys Val Asp Ala Thr Ala Glu 
225                 230                 235                 240 


Thr Asp Leu Ala Lys Arg Phe Asp Val Ser Gly Tyr Pro Thr Leu Lys 
                245                 250                 255     


Ile Phe Arg Lys Gly Arg Pro Tyr Asp Tyr Asn Gly Pro Arg Glu Lys 
            260                 265                 270         


Tyr Gly Ile Val Asp Tyr Met Ile Glu Gln Ser Gly Pro Pro Ser Lys 
        275                 280                 285             


Glu Ile Leu Thr Leu Lys Gln Val Gln Glu Phe Leu Lys Asp Gly Asp 
    290                 295                 300                 


Asp Val Ile Ile Ile Gly Val Phe Lys Gly Glu Ser Asp Pro Ala Tyr 
305                 310                 315                 320 


Gln Gln Tyr Gln Asp Ala Ala Asn Asn Leu Arg Glu Asp Tyr Lys Phe 
                325                 330                 335     


His His Thr Phe Ser Thr Glu Ile Ala Lys Phe Leu Lys Val Ser Gln 
            340                 345                 350         


Gly Gln Leu Val Val Met Gln Pro Glu Lys Phe Gln Ser Lys Tyr Glu 
        355                 360                 365             


Pro Arg Ser His Met Met Asp Val Gln Gly Ser Thr Gln Asp Ser Ala 
    370                 375                 380                 


Ile Lys Asp Phe Val Leu Lys Tyr Ala Leu Pro Leu Val Gly His Arg 
385                 390                 395                 400 


Lys Val Ser Asn Asp Ala Lys Arg Tyr Thr Arg Arg Pro Leu Val Val 
                405                 410                 415     


Val Tyr Tyr Ser Val Asp Phe Ser Phe Asp Tyr Arg Ala Ala Thr Gln 
            420                 425                 430         


Phe Trp Arg Ser Lys Val Leu Glu Val Ala Lys Asp Phe Pro Glu Tyr 
        435                 440                 445             


Thr Phe Ala Ile Ala Asp Glu Glu Asp Tyr Ala Gly Glu Val Lys Asp 
    450                 455                 460                 


Leu Gly Leu Ser Glu Ser Gly Glu Asp Val Asn Ala Ala Ile Leu Asp 
465                 470                 475                 480 


Glu Ser Gly Lys Lys Phe Ala Met Glu Pro Glu Glu Phe Asp Ser Asp 
                485                 490                 495     


Thr Leu Arg Glu Phe Val Thr Ala Phe Lys Lys Gly Lys Leu Lys Pro 
            500                 505                 510         


Val Ile Lys Ser Gln Pro Val Pro Lys Asn Asn Lys Gly Pro Val Lys 
        515                 520                 525             


Val Val Val Gly Lys Thr Phe Asp Ser Ile Val Met Asp Pro Lys Lys 
    530                 535                 540                 


Asp Val Leu Ile Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Gln 
545                 550                 555                 560 


Leu Glu Pro Val Tyr Asn Ser Leu Ala Lys Lys Tyr Lys Gly Gln Lys 
                565                 570                 575     


Gly Leu Val Ile Ala Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser 
            580                 585                 590         


Asp Arg Tyr Lys Val Glu Gly Phe Pro Thr Ile Tyr Phe Ala Pro Ser 
        595                 600                 605             


Gly Asp Lys Lys Asn Pro Val Lys Phe Glu Gly Gly Asp Arg Asp Leu 
    610                 615                 620                 


Glu His Leu Ser Lys Phe Ile Glu Glu His Ala Thr Lys Leu Ser Arg 
625                 630                 635                 640 


Thr Lys Glu Glu Leu 
                645 


<210>  35
<211>  236
<212>  PRT
<213>  Escherichia coli

<400>  35

Met Lys Lys Gly Phe Met Leu Phe Thr Leu Leu Ala Ala Phe Ser Gly 
1               5                   10                  15      


Phe Ala Gln Ala Asp Asp Ala Ala Ile Gln Gln Thr Leu Ala Lys Met 
            20                  25                  30          


Gly Ile Lys Ser Ser Asp Ile Gln Pro Ala Pro Val Ala Gly Met Lys 
        35                  40                  45              


Thr Val Leu Thr Asn Ser Gly Val Leu Tyr Ile Thr Asp Asp Gly Lys 
    50                  55                  60                  


His Ile Ile Gln Gly Pro Met Tyr Asp Val Ser Gly Thr Ala Pro Val 
65                  70                  75                  80  


Asn Val Thr Asn Lys Met Leu Leu Lys Gln Leu Asn Ala Leu Glu Lys 
                85                  90                  95      


Glu Met Ile Val Tyr Lys Ala Pro Gln Glu Lys His Val Ile Thr Val 
            100                 105                 110         


Phe Thr Asp Ile Thr Cys Gly Tyr Cys His Lys Leu His Glu Gln Met 
        115                 120                 125             


Ala Asp Tyr Asn Ala Leu Gly Ile Thr Val Arg Tyr Leu Ala Phe Pro 
    130                 135                 140                 


Arg Gln Gly Leu Asp Ser Asp Ala Glu Lys Glu Met Lys Ala Ile Trp 
145                 150                 155                 160 


Cys Ala Lys Asp Lys Asn Lys Ala Phe Asp Asp Val Met Ala Gly Lys 
                165                 170                 175     


Ser Val Ala Pro Ala Ser Cys Asp Val Asp Ile Ala Asp His Tyr Ala 
            180                 185                 190         


Leu Gly Val Gln Leu Gly Val Ser Gly Thr Pro Ala Val Val Leu Ser 
        195                 200                 205             


Asn Gly Thr Leu Val Pro Gly Tyr Gln Pro Pro Lys Glu Met Lys Glu 
    210                 215                 220                 


Phe Leu Asp Glu His Gln Lys Met Thr Ser Gly Lys 
225                 230                 235     


<210>  36
<211>  1179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APO-3 hPDI-quiescin-sulfydryl oxidase fusion protein 
       (hPDI-QSOX1b)

<400>  36

Met Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
1               5                   10                  15      


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
            20                  25                  30          


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
        35                  40                  45              


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
    50                  55                  60                  


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
65                  70                  75                  80  


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
                85                  90                  95      


Gly Gly Met Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg 
            100                 105                 110         


Lys Ser Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val 
        115                 120                 125             


Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu 
    130                 135                 140                 


Tyr Ala Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg 
145                 150                 155                 160 


Leu Ala Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr 
                165                 170                 175     


Gly Val Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr 
            180                 185                 190         


Ala Ser Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val 
        195                 200                 205             


Asn Trp Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp 
    210                 215                 220                 


Gly Ala Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile 
225                 230                 235                 240 


Gly Phe Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln 
                245                 250                 255     


Ala Ala Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser 
            260                 265                 270         


Asp Val Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe 
        275                 280                 285             


Lys Lys Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys 
    290                 295                 300                 


Glu Asn Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile 
305                 310                 315                 320 


Glu Phe Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys 
                325                 330                 335     


Thr His Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly 
            340                 345                 350         


Lys Leu Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile 
        355                 360                 365             


Leu Phe Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu 
    370                 375                 380                 


Glu Phe Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile 
385                 390                 395                 400 


Thr Leu Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu 
                405                 410                 415     


Thr Ala Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys 
            420                 425                 430         


Ile Lys Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys 
        435                 440                 445             


Gln Pro Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe 
    450                 455                 460                 


Asp Glu Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly 
465                 470                 475                 480 


His Cys Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr 
                485                 490                 495     


Lys Asp His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn 
            500                 505                 510         


Glu Val Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe 
        515                 520                 525             


Pro Ala Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr 
    530                 535                 540                 


Leu Asp Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala 
545                 550                 555                 560 


Gly Asp Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp 
                565                 570                 575     


Met Glu Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu Pro Thr 
            580                 585                 590         


Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Ala Pro Arg Ser 
        595                 600                 605             


Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp Thr 
    610                 615                 620                 


Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu Phe 
625                 630                 635                 640 


Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp Lys 
                645                 650                 655     


Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu Ala 
            660                 665                 670         


Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp Phe 
        675                 680                 685             


Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr Lys 
    690                 695                 700                 


Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln Thr 
705                 710                 715                 720 


Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr Trp 
                725                 730                 735     


Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile Asp 
            740                 745                 750         


Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe Glu 
        755                 760                 765             


Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser Gln 
    770                 775                 780                 


His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn Val 
785                 790                 795                 800 


Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu Phe 
                805                 810                 815     


Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg Ser 
            820                 825                 830         


Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu Ala 
        835                 840                 845             


Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro Thr 
    850                 855                 860                 


Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu Glu 
865                 870                 875                 880 


Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro Val 
                885                 890                 895     


Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val Leu 
            900                 905                 910         


Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His Ser 
        915                 920                 925             


Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr Ser 
    930                 935                 940                 


Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu Ala 
945                 950                 955                 960 


Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe Arg 
                965                 970                 975     


Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val Gln 
            980                 985                 990         


Ala Ala Arg Gln Asn Val Asp His  Ser Gln Glu Ala Ala  Lys Ala Lys 
        995                 1000                 1005             


Glu Val  Leu Pro Ala Ile Arg  Gly Tyr Val His Tyr  Phe Phe Gly 
    1010                 1015                 1020             


Cys Arg  Asp Cys Ala Ser His  Phe Glu Gln Met Ala  Ala Ala Ser 
    1025                 1030                 1035             


Met His  Arg Val Gly Ser Pro  Asn Ala Ala Val Leu  Trp Leu Trp 
    1040                 1045                 1050             


Ser Ser  His Asn Arg Val Asn  Ala Arg Leu Ala Gly  Ala Pro Ser 
    1055                 1060                 1065             


Glu Asp  Pro Gln Phe Pro Lys  Val Gln Trp Pro Pro  Arg Glu Leu 
    1070                 1075                 1080             


Cys Ser  Ala Cys His Asn Glu  Arg Leu Asp Val Pro  Val Trp Asp 
    1085                 1090                 1095             


Val Glu  Ala Thr Leu Asn Phe  Leu Lys Ala His Phe  Ser Pro Ser 
    1100                 1105                 1110             


Asn Ile  Ile Leu Asp Phe Pro  Ala Ala Gly Ser Ala  Ala Arg Arg 
    1115                 1120                 1125             


Asp Val  Gln Asn Val Ala Ala  Ala Pro Glu Leu Ala  Met Gly Ala 
    1130                 1135                 1140             


Leu Glu  Leu Glu Ser Arg Asn  Ser Thr Leu Asp Pro  Gly Lys Pro 
    1145                 1150                 1155             


Glu Met  Met Lys Ser Pro Thr  Asn Thr Thr Pro His  Val Pro Ala 
    1160                 1165                 1170             


Glu Gly  Pro Glu Leu Ile 
    1175                 


<210>  37
<211>  300
<212>  PRT
<213>  Campylobacter jejuni

<400>  37

Met Thr Arg Thr Arg Met Glu Asn Glu Leu Ile Val Ser Lys Asn Met 
1               5                   10                  15      


Gln Asn Ile Ile Ile Ala Gly Asn Gly Pro Ser Leu Lys Asn Ile Asn 
            20                  25                  30          


Tyr Lys Arg Leu Pro Arg Glu Tyr Asp Val Phe Arg Cys Asn Gln Phe 
        35                  40                  45              


Tyr Phe Glu Asp Lys Tyr Tyr Leu Gly Lys Lys Ile Lys Ala Val Phe 
    50                  55                  60                  


Phe Asn Pro Gly Val Phe Leu Gln Gln Tyr His Thr Ala Lys Gln Leu 
65                  70                  75                  80  


Ile Leu Lys Asn Glu Tyr Glu Ile Lys Asn Ile Phe Cys Ser Thr Phe 
                85                  90                  95      


Asn Leu Pro Phe Ile Glu Ser Asn Asp Phe Leu His Gln Phe Tyr Asn 
            100                 105                 110         


Phe Phe Pro Asp Ala Lys Leu Gly Tyr Glu Val Ile Glu Asn Leu Lys 
        115                 120                 125             


Glu Phe Tyr Ala Tyr Ile Lys Tyr Asn Glu Ile Tyr Phe Asn Lys Arg 
    130                 135                 140                 


Ile Thr Ser Gly Val Tyr Met Cys Ala Ile Ala Ile Ala Leu Gly Tyr 
145                 150                 155                 160 


Lys Thr Ile Tyr Leu Cys Gly Ile Asp Phe Tyr Glu Gly Asp Val Ile 
                165                 170                 175     


Tyr Pro Phe Glu Ala Met Ser Thr Asn Ile Lys Thr Ile Phe Pro Gly 
            180                 185                 190         


Ile Lys Asp Phe Lys Pro Ser Asn Cys His Ser Lys Glu Tyr Asp Ile 
        195                 200                 205             


Glu Ala Leu Lys Leu Leu Lys Ser Ile Tyr Lys Val Asn Ile Tyr Ala 
    210                 215                 220                 


Leu Cys Asp Asp Ser Ile Leu Ala Asn His Phe Pro Leu Ser Ile Asn 
225                 230                 235                 240 


Ile Asn Asn Asn Phe Thr Leu Glu Asn Lys His Asn Asn Ser Ile Asn 
                245                 250                 255     


Asp Ile Leu Leu Thr Asp Asn Thr Pro Gly Val Ser Phe Tyr Lys Asn 
            260                 265                 270         


Gln Leu Lys Ala Asp Asn Lys Ile Met Leu Asn Phe Tyr Asn Ile Leu 
        275                 280                 285             


His Ser Lys Asp Asn Leu Ile Lys Phe Leu Asn Lys 
    290                 295                 300 


<210>  38
<211>  285
<212>  PRT
<213>  Sus scrofa domesticus

<400>  38

Met Arg Pro Cys Thr Cys Thr Arg Cys Ile Glu Glu Gln Arg Val Ser 
1               5                   10                  15      


Ala Trp Phe Asp Glu Arg Phe Asn Arg Ser Met Gln Pro Leu Leu Thr 
            20                  25                  30          


Ala Lys Asn Ala His Leu Glu Glu Asp Thr Tyr Lys Trp Trp Leu Arg 
        35                  40                  45              


Leu Gln Arg Glu Lys Gln Pro Asn Asn Leu Asn Asp Thr Ile Arg Glu 
    50                  55                  60                  


Leu Phe Gln Val Val Pro Gly Asn Val Asp Pro Leu Leu Glu Lys Arg 
65                  70                  75                  80  


Leu Val Ser Cys Arg Arg Cys Ala Val Val Gly Asn Ser Gly Asn Leu 
                85                  90                  95      


Lys Glu Ser Tyr Tyr Gly Pro Gln Ile Asp Ser His Asp Phe Val Leu 
            100                 105                 110         


Arg Met Asn Lys Ala Pro Thr Glu Gly Phe Glu Ala Asp Val Gly Ser 
        115                 120                 125             


Lys Thr Thr His His Phe Val Tyr Pro Glu Ser Phe Arg Glu Leu Ala 
    130                 135                 140                 


Gln Glu Val Ser Met Ile Leu Val Pro Phe Lys Thr Thr Asp Leu Glu 
145                 150                 155                 160 


Trp Val Ile Ser Ala Thr Thr Thr Gly Arg Ile Ser His Thr Tyr Val 
                165                 170                 175     


Pro Val Pro Ala Lys Ile Lys Val Lys Lys Glu Lys Ile Leu Ile Tyr 
            180                 185                 190         


His Pro Ala Phe Ile Lys Tyr Val Phe Asp Arg Trp Leu Gln Gly His 
        195                 200                 205             


Gly Arg Tyr Pro Ser Thr Gly Ile Leu Ser Val Ile Phe Ser Leu His 
    210                 215                 220                 


Ile Cys Asp Glu Val Asp Leu Tyr Gly Phe Gly Ala Asp Ser Lys Gly 
225                 230                 235                 240 


Asn Trp His His Tyr Trp Glu Asn Asn Pro Ser Ala Gly Ala Phe Arg 
                245                 250                 255     


Lys Thr Gly Val His Asp Gly Asp Phe Glu Ser Asn Val Thr Thr Ile 
            260                 265                 270         


Leu Ala Ser Ile Asn Lys Ile Arg Ile Phe Lys Gly Arg 
        275                 280                 285 


<210>  39
<211>  236
<212>  PRT
<213>  Campylobacter jejuni

<400>  39

Met Lys Lys Gly Phe Met Leu Phe Thr Leu Leu Ala Ala Phe Ser Gly 
1               5                   10                  15      


Phe Ala Gln Ala Asp Asp Ala Ala Ile Gln Gln Thr Leu Ala Lys Met 
            20                  25                  30          


Gly Ile Lys Ser Ser Asp Ile Gln Pro Ala Pro Val Ala Gly Met Lys 
        35                  40                  45              


Thr Val Leu Thr Asn Ser Gly Val Leu Tyr Ile Thr Asp Asp Gly Lys 
    50                  55                  60                  


His Ile Ile Gln Gly Pro Met Tyr Asp Val Ser Gly Thr Ala Pro Val 
65                  70                  75                  80  


Asn Val Thr Asn Lys Met Leu Leu Lys Gln Leu Asn Ala Leu Glu Lys 
                85                  90                  95      


Glu Met Ile Val Tyr Lys Ala Pro Gln Glu Lys His Val Ile Thr Val 
            100                 105                 110         


Phe Thr Asp Ile Thr Cys Gly Tyr Cys His Lys Leu His Glu Gln Met 
        115                 120                 125             


Ala Asp Tyr Asn Ala Leu Gly Ile Thr Val Arg Tyr Leu Ala Phe Pro 
    130                 135                 140                 


Arg Gln Gly Leu Asp Ser Asp Ala Glu Lys Glu Met Lys Ala Ile Trp 
145                 150                 155                 160 


Cys Ala Lys Asp Lys Asn Lys Ala Phe Asp Asp Val Met Ala Gly Lys 
                165                 170                 175     


Ser Val Ala Pro Ala Ser Cys Asp Val Asp Ile Ala Asp His Tyr Ala 
            180                 185                 190         


Leu Gly Val Gln Leu Gly Val Ser Gly Thr Pro Ala Val Val Leu Ser 
        195                 200                 205             


Asn Gly Thr Leu Val Pro Gly Tyr Gln Pro Pro Lys Glu Met Lys Glu 
    210                 215                 220                 


Phe Leu Asp Glu His Gln Lys Met Thr Ser Gly Lys 
225                 230                 235     


<210>  40
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Val Thr Leu Arg Lys Arg Thr Leu Lys Val Leu Thr Phe Leu Val 
1               5                   10                  15      


Leu Phe Ile Phe Leu Thr Ser Phe Phe Leu Asn Tyr Ser His Thr Met 
            20                  25                  30          


Val Ala Thr Thr Trp Phe Pro Lys Gln Met Val Leu Glu Leu Ser Glu 
        35                  40                  45              


Asn Leu Lys Arg Leu Ile Lys His Arg Pro Cys Thr Cys Thr His Cys 
    50                  55                  60                  


Ile Gly Gln Arg Lys Leu Ser Ala Trp Phe Asp Glu Arg Phe Asn Gln 
65                  70                  75                  80  


Thr Met Gln Pro Leu Leu Thr Ala Gln Asn Ala Leu Leu Glu Asp Asp 
                85                  90                  95      


Thr Tyr Arg Trp Trp Leu Arg Leu Gln Arg Glu Lys Lys Pro Asn Asn 
            100                 105                 110         


Leu Asn Asp Thr Ile Lys Glu Leu Phe Arg Val Val Pro Gly Asn Val 
        115                 120                 125             


Asp Pro Met Leu Glu Lys Arg Ser Val Gly Cys Arg Arg Cys Ala Val 
    130                 135                 140                 


Val Gly Asn Ser Gly Asn Leu Arg Glu Ser Ser Tyr Gly Pro Glu Ile 
145                 150                 155                 160 


Asp Ser His Asp Phe Val Leu Arg Met Asn Lys Ala Pro Thr Ala Gly 
                165                 170                 175     


Phe Glu Ala Asp Val Gly Thr Lys Thr Thr His His Leu Val Tyr Pro 
            180                 185                 190         


Glu Ser Phe Arg Glu Leu Gly Asp Asn Val Ser Met Ile Leu Val Pro 
        195                 200                 205             


Phe Lys Thr Ile Asp Leu Glu Trp Val Val Ser Ala Ile Thr Thr Gly 
    210                 215                 220                 


Thr Ile Ser His Thr Tyr Ile Pro Val Pro Ala Lys Ile Arg Val Lys 
225                 230                 235                 240 


Gln Asp Lys Ile Leu Ile Tyr His Pro Ala Phe Ile Lys Tyr Val Phe 
                245                 250                 255     


Asp Asn Trp Leu Gln Gly His Gly Arg Tyr Pro Ser Thr Gly Ile Leu 
            260                 265                 270         


Ser Val Ile Phe Ser Met His Val Cys Asp Glu Val Asp Leu Tyr Gly 
        275                 280                 285             


Phe Gly Ala Asp Ser Lys Gly Asn Trp His His Tyr Trp Glu Asn Asn 
    290                 295                 300                 


Pro Ser Ala Gly Ala Phe Arg Lys Thr Gly Val His Asp Ala Asp Phe 
305                 310                 315                 320 


Glu Ser Asn Val Thr Ala Thr Leu Ala Ser Ile Asn Lys Ile Arg Ile 
                325                 330                 335     


Phe Lys Gly Arg 
            340 


<210>  41
<211>  290
<212>  PRT
<213>  Campylobacter jejuni

<400>  41

Met Lys Lys Val Ile Ile Ala Gly Asn Gly Pro Ser Leu Lys Glu Ile 
1               5                   10                  15      


Asp Tyr Ser Arg Leu Pro Asn Asp Phe Asp Val Phe Arg Cys Asn Gln 
            20                  25                  30          


Phe Tyr Phe Glu Asp Lys Tyr Tyr Leu Gly Lys Lys Cys Lys Ala Val 
        35                  40                  45              


Phe Tyr Asn Pro Ile Leu Phe Phe Glu Gln Tyr Tyr Thr Leu Lys His 
    50                  55                  60                  


Leu Ile Gln Asn Gln Glu Tyr Glu Thr Glu Leu Ile Met Cys Ser Asn 
65                  70                  75                  80  


Tyr Asn Gln Ala His Leu Glu Asn Glu Asn Phe Val Lys Thr Phe Tyr 
                85                  90                  95      


Asp Tyr Phe Pro Asp Ala His Leu Gly Tyr Asp Phe Phe Lys Gln Leu 
            100                 105                 110         


Lys Asp Phe Asn Ala Tyr Phe Lys Phe His Glu Ile Tyr Phe Asn Gln 
        115                 120                 125             


Arg Ile Thr Ser Gly Val Tyr Met Cys Ala Val Ala Ile Ala Leu Gly 
    130                 135                 140                 


Tyr Lys Glu Ile Tyr Leu Ser Gly Ile Asp Phe Tyr Gln Asn Gly Ser 
145                 150                 155                 160 


Ser Tyr Ala Phe Asp Thr Lys Gln Lys Asn Leu Leu Lys Leu Ala Pro 
                165                 170                 175     


Asn Phe Lys Asn Asp Asn Ser His Tyr Ile Gly His Ser Lys Asn Thr 
            180                 185                 190         


Asp Ile Lys Ala Leu Glu Phe Leu Glu Lys Thr Tyr Lys Ile Lys Leu 
        195                 200                 205             


Tyr Cys Leu Cys Pro Asn Ser Leu Leu Ala Asn Phe Ile Glu Leu Ala 
    210                 215                 220                 


Pro Asn Leu Asn Ser Asn Phe Ile Ile Gln Glu Lys Asn Asn Tyr Thr 
225                 230                 235                 240 


Lys Asp Ile Leu Ile Pro Ser Ser Glu Ala Tyr Gly Lys Phe Ser Lys 
                245                 250                 255     


Asn Ile Asn Phe Lys Lys Ile Lys Ile Lys Glu Asn Ile Tyr Tyr Lys 
            260                 265                 270         


Leu Ile Lys Asp Leu Leu Arg Leu Pro Ser Asp Ile Lys His Tyr Phe 
        275                 280                 285             


Lys Gly 
    290 


<210>  42
<211>  260
<212>  PRT
<213>  Campylobacter jejuni

<400>  42

Met Lys Lys Val Ile Ile Ala Gly Asn Gly Pro Ser Leu Lys Glu Ile 
1               5                   10                  15      


Asp Tyr Ser Arg Leu Pro Asn Asp Phe Asp Val Phe Arg Cys Asn Gln 
            20                  25                  30          


Phe Tyr Phe Glu Asp Lys Tyr Tyr Leu Gly Lys Lys Cys Lys Ala Val 
        35                  40                  45              


Phe Tyr Asn Pro Ser Leu Phe Phe Glu Gln Tyr Tyr Thr Leu Lys His 
    50                  55                  60                  


Leu Ile Gln Asn Gln Glu Tyr Glu Thr Glu Leu Ile Met Cys Ser Asn 
65                  70                  75                  80  


Tyr Asn Gln Ala His Leu Glu Asn Glu Asn Phe Val Lys Thr Phe Tyr 
                85                  90                  95      


Asp Tyr Phe Pro Asp Ala His Leu Gly Tyr Asp Phe Phe Lys Gln Leu 
            100                 105                 110         


Lys Asp Phe Asn Ala Tyr Phe Lys Phe His Glu Ile Tyr Phe Asn Gln 
        115                 120                 125             


Arg Ile Thr Ser Gly Val Tyr Met Cys Ala Val Ala Ile Ala Leu Gly 
    130                 135                 140                 


Tyr Lys Glu Ile Tyr Leu Ser Gly Ile Asp Phe Tyr Gln Asn Gly Ser 
145                 150                 155                 160 


Ser Tyr Ala Phe Asp Thr Lys Gln Lys Asn Leu Leu Lys Leu Ala Pro 
                165                 170                 175     


Asn Phe Lys Asn Asp Asn Ser His Tyr Ile Gly His Ser Lys Asn Thr 
            180                 185                 190         


Asp Ile Lys Ala Leu Glu Phe Leu Glu Lys Thr Tyr Lys Ile Lys Leu 
        195                 200                 205             


Tyr Cys Leu Cys Pro Asn Ser Leu Leu Ala Asn Phe Ile Glu Leu Ala 
    210                 215                 220                 


Pro Asn Leu Asn Ser Asn Phe Ile Ile Gln Glu Lys Asn Asn Tyr Thr 
225                 230                 235                 240 


Lys Asp Ile Leu Ile Pro Ser Ser Glu Ala Tyr Gly Lys Phe Ser Lys 
                245                 250                 255     


Asn Ile Asn Phe 
            260 


<210>  43
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  43

Ser Lys Ala Ser Asn Ser Trp Thr Gly Lys Gly Gln Ala Cys Arg His 
1               5                   10                  15      


Leu Leu His Leu Ala Ile Gln Arg His Pro His Phe Arg Gly Leu Phe 
            20                  25                  30          


Asn Leu Ser Ile Pro Val Leu Leu Trp Gly Asp Leu Phe Thr Pro Ala 
        35                  40                  45              


Leu Trp Asp Arg Leu Ser Gln His Lys Ala Pro Tyr Gly Trp Arg Gly 
    50                  55                  60                  


Leu Ser His Gln Val Ile Ala Ser Thr Leu Ser Leu Leu Asn Gly Ser 
65                  70                  75                  80  


Glu Ser Ala Lys Leu Phe Ala Pro Pro Arg Asp Thr Pro Pro Lys Cys 
                85                  90                  95      


Ile Arg Cys Ala Val Val Gly Asn Gly Gly Ile Leu Asn Gly Ser Arg 
            100                 105                 110         


Gln Gly Pro Asn Ile Asp Ala His Asp Tyr Val Phe Arg Leu Asn Gly 
        115                 120                 125             


Ala Val Ile Lys Gly Phe Glu Arg Asp Val Gly Thr Lys Thr Ser Phe 
    130                 135                 140                 


Tyr Gly Phe Thr Val Asn Thr Met Lys Asn Ser Leu Val Ser Tyr Trp 
145                 150                 155                 160 


Asn Leu Gly Phe Thr Ser Val Pro Gln Gly Gln Asp Leu Gln Tyr Ile 
                165                 170                 175     


Phe Ile Pro Ser Asp Ile Arg Asp Tyr Val Met Leu Arg Ser Ala Ile 
            180                 185                 190         


Leu Gly Val Pro Val Pro Glu Gly Leu Asp Lys Gly Asp Arg Pro His 
        195                 200                 205             


Ala Tyr Phe Gly Pro Glu Ala Ser Ala Ser Lys Phe Lys Leu Leu His 
    210                 215                 220                 


Pro Asp Phe Ile Ser Tyr Leu Thr Glu Arg Phe Leu Lys Ser Lys Leu 
225                 230                 235                 240 


Ile Asn Thr His Phe Gly Asp Leu Tyr Met Pro Ser Thr Gly Ala Leu 
                245                 250                 255     


Met Leu Leu Thr Ala Leu His Thr Cys Asp Gln Val Ser Ala Tyr Gly 
            260                 265                 270         


Phe Ile Thr Ser Asn Tyr Trp Lys Phe Ser Asp His Tyr Phe Glu Arg 
        275                 280                 285             


Lys Met Lys Pro Leu Ile Phe Tyr Ala Asn His Asp Leu Ser Leu Glu 
    290                 295                 300                 


Ala Ala Leu Trp Arg Asp Leu His Lys Ala Gly Ile Leu Gln Leu Tyr 
305                 310                 315                 320 


Gln Arg 
        


<210>  44
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Thr Cys Leu Asp His His Phe Pro Thr Gly Ser Arg Pro Thr Val 
1               5                   10                  15      


Pro Gly Pro Leu His Phe Ser Gly Tyr Ser Ser Val Pro Asp Gly Lys 
            20                  25                  30          


Pro Leu Val Arg Glu Pro Cys Arg Ser Cys Ala Val Val Ser Ser Ser 
        35                  40                  45              


Gly Gln Met Leu Gly Ser Gly Leu Gly Ala Glu Ile Asp Ser Ala Glu 
    50                  55                  60                  


Cys Val Phe Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu Ala Asp 
65                  70                  75                  80  


Val Gly Gln Arg Ser Thr Leu Arg Val Val Ser His Thr Ser Val Pro 
                85                  90                  95      


Leu Leu Leu Arg Asn Tyr Ser His Tyr Phe Gln Lys Ala Arg Asp Thr 
            100                 105                 110         


Leu Tyr Met Val Trp Gly Gln Gly Arg His Met Asp Arg Val Leu Gly 
        115                 120                 125             


Gly Arg Thr Tyr Arg Thr Leu Leu Gln Leu Thr Arg Met Tyr Pro Gly 
    130                 135                 140                 


Leu Gln Val Tyr Thr Phe Thr Glu Arg Met Met Ala Tyr Cys Asp Gln 
145                 150                 155                 160 


Ile Phe Gln Asp Glu Thr Gly Lys Asn Arg Arg Gln Ser Gly Ser Phe 
                165                 170                 175     


Leu Ser Thr Gly Trp Phe Thr Met Ile Leu Ala Leu Glu Leu Cys Glu 
            180                 185                 190         


Glu Ile Val Val Tyr Gly Met Val Ser Asp Ser Tyr Cys Arg Glu Lys 
        195                 200                 205             


Ser His Pro Ser Val Pro Tyr His Tyr Phe Glu Lys Gly Arg Leu Asp 
    210                 215                 220                 


Glu Cys Gln Met Tyr Leu Ala His Glu Gln Ala Pro Arg Ser Ala His 
225                 230                 235                 240 


Arg Phe Ile Thr Glu Lys Ala Val Phe Ser Arg Trp Ala Lys Lys Arg 
                245                 250                 255     


Pro Ile Val Phe Ala His Pro Ser Trp Arg Thr Glu 
            260                 265             


<210>  45
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Gly Leu Pro Arg Gly Ser Phe Phe Trp Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Ala Ala Cys Ser Gly Leu Leu Phe Ala Leu Tyr Phe Ser Ala Val Gln 
            20                  25                  30          


Arg Tyr Pro Gly Pro Ala Ala Gly Ala Arg Asp Thr Thr Ser Phe Glu 
        35                  40                  45              


Ala Phe Phe Gln Ser Lys Ala Ser Asn Ser Trp Thr Gly Lys Gly Gln 
    50                  55                  60                  


Ala Cys Arg His Leu Leu His Leu Ala Ile Gln Arg His Pro His Phe 
65                  70                  75                  80  


Arg Gly Leu Phe Asn Leu Ser Ile Pro Val Leu Leu Trp Gly Asp Leu 
                85                  90                  95      


Phe Thr Pro Ala Leu Trp Asp Arg Leu Ser Gln His Lys Ala Pro Tyr 
            100                 105                 110         


Gly Trp Arg Gly Leu Ser His Gln Val Ile Ala Ser Thr Leu Ser Leu 
        115                 120                 125             


Leu Asn Gly Ser Glu Ser Ala Lys Leu Phe Ala Pro Pro Arg Asp Thr 
    130                 135                 140                 


Pro Pro Lys Cys Ile Arg Cys Ala Val Val Gly Asn Gly Gly Ile Leu 
145                 150                 155                 160 


Asn Gly Ser Arg Gln Gly Pro Asn Ile Asp Ala His Asp Tyr Val Phe 
                165                 170                 175     


Arg Leu Asn Gly Ala Val Ile Lys Gly Phe Glu Arg Asp Val Gly Thr 
            180                 185                 190         


Lys Thr Ser Phe Tyr Gly Phe Thr Val Asn Thr Met Lys Asn Ser Leu 
        195                 200                 205             


Val Ser Tyr Trp Asn Leu Gly Phe Thr Ser Val Pro Gln Gly Gln Asp 
    210                 215                 220                 


Leu Gln Tyr Ile Phe Ile Pro Ser Asp Ile Arg Asp Tyr Val Met Leu 
225                 230                 235                 240 


Arg Ser Ala Ile Leu Gly Val Pro Val Pro Glu Gly Leu Asp Lys Gly 
                245                 250                 255     


Asp Arg Pro His Ala Tyr Phe Gly Pro Glu Ala Ser Ala Ser Lys Phe 
            260                 265                 270         


Lys Leu Leu His Pro Asp Phe Ile Ser Tyr Leu Thr Glu Arg Phe Leu 
        275                 280                 285             


Lys Ser Lys Leu Ile Asn Thr His Phe Gly Asp Leu Tyr Met Pro Ser 
    290                 295                 300                 


Thr Gly Ala Leu Met Leu Leu Thr Ala Leu His Thr Cys Asp Gln Val 
305                 310                 315                 320 


Ser Ala Tyr Gly Phe Ile Thr Ser Asn Tyr Trp Lys Phe Ser Asp His 
                325                 330                 335     


Tyr Phe Glu Arg Lys Met Lys Pro Leu Ile Phe Tyr Ala Asn His Asp 
            340                 345                 350         


Leu Ser Leu Glu Ala Ala Leu Trp Arg Asp Leu His Lys Ala Gly Ile 
        355                 360                 365             


Leu Gln Leu Tyr Gln Arg 
    370                 


<210>  46
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Lys Ala Pro Gly Arg Leu Val Leu Ile Ile Leu Cys Ser Val Val 
1               5                   10                  15      


Phe Ser Ala Val Tyr Ile Leu Leu Cys Cys Trp Ala Gly Leu Pro Leu 
            20                  25                  30          


Cys Leu Ala Thr Cys Leu Asp His His Phe Pro Thr Gly Ser Arg Pro 
        35                  40                  45              


Thr Val Pro Gly Pro Leu His Phe Ser Gly Tyr Ser Ser Val Pro Asp 
    50                  55                  60                  


Gly Lys Pro Leu Val Arg Glu Pro Cys Arg Ser Cys Ala Val Val Ser 
65                  70                  75                  80  


Ser Ser Gly Gln Met Leu Gly Ser Gly Leu Gly Ala Glu Ile Asp Ser 
                85                  90                  95      


Ala Glu Cys Val Phe Arg Met Asn Gln Ala Pro Thr Val Gly Phe Glu 
            100                 105                 110         


Ala Asp Val Gly Gln Arg Ser Thr Leu Arg Val Val Ser His Thr Ser 
        115                 120                 125             


Val Pro Leu Leu Leu Arg Asn Tyr Ser His Tyr Phe Gln Lys Ala Arg 
    130                 135                 140                 


Asp Thr Leu Tyr Met Val Trp Gly Gln Gly Arg His Met Asp Arg Val 
145                 150                 155                 160 


Leu Gly Gly Arg Thr Tyr Arg Thr Leu Leu Gln Leu Thr Arg Met Tyr 
                165                 170                 175     


Pro Gly Leu Gln Val Tyr Thr Phe Thr Glu Arg Met Met Ala Tyr Cys 
            180                 185                 190         


Asp Gln Ile Phe Gln Asp Glu Thr Gly Lys Asn Arg Arg Gln Ser Gly 
        195                 200                 205             


Ser Phe Leu Ser Thr Gly Trp Phe Thr Met Ile Leu Ala Leu Glu Leu 
    210                 215                 220                 


Cys Glu Glu Ile Val Val Tyr Gly Met Val Ser Asp Ser Tyr Cys Arg 
225                 230                 235                 240 


Glu Lys Ser His Pro Ser Val Pro Tyr His Tyr Phe Glu Lys Gly Arg 
                245                 250                 255     


Leu Asp Glu Cys Gln Met Tyr Leu Ala His Glu Gln Ala Pro Arg Ser 
            260                 265                 270         


Ala His Arg Phe Ile Thr Glu Lys Ala Val Phe Ser Arg Trp Ala Lys 
        275                 280                 285             


Lys Arg Pro Ile Val Phe Ala His Pro Ser Trp Arg Thr Glu 
    290                 295                 300         


<210>  47
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Lys Thr Leu Met Arg His Gly Leu Ala Val Cys Leu Ala Leu Thr 
1               5                   10                  15      


Thr Met Cys Thr Ser Leu Leu Leu Val Tyr Ser Ser Leu Gly Gly Gln 
            20                  25                  30          


Lys Glu Arg Pro Pro Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Ala Ser Ala Thr Gly Ser Ser Gln Pro Ala Ala Glu Ser Ser Thr 
    50                  55                  60                  


Gln Gln Arg Pro Gly Val Pro Ala Gly Pro Arg Pro Leu Asp Gly Tyr 
65                  70                  75                  80  


Leu Gly Val Ala Asp His Lys Pro Leu Lys Met His Cys Arg Asp Cys 
                85                  90                  95      


Ala Leu Val Thr Ser Ser Gly His Leu Leu His Ser Arg Gln Gly Ser 
            100                 105                 110         


Gln Ile Asp Gln Thr Glu Cys Val Ile Arg Met Asn Asp Ala Pro Thr 
        115                 120                 125             


Arg Gly Tyr Gly Arg Asp Val Gly Asn Arg Thr Ser Leu Arg Val Ile 
    130                 135                 140                 


Ala His Ser Ser Ile Gln Arg Ile Leu Arg Asn Arg His Asp Leu Leu 
145                 150                 155                 160 


Asn Val Ser Gln Gly Thr Val Phe Ile Phe Trp Gly Pro Ser Ser Tyr 
                165                 170                 175     


Met Arg Arg Asp Gly Lys Gly Gln Val Tyr Asn Asn Leu His Leu Leu 
            180                 185                 190         


Ser Gln Val Leu Pro Arg Leu Lys Ala Phe Met Ile Thr Arg His Lys 
        195                 200                 205             


Met Leu Gln Phe Asp Glu Leu Phe Lys Gln Glu Thr Gly Lys Asp Arg 
    210                 215                 220                 


Lys Ile Ser Asn Thr Trp Leu Ser Thr Gly Trp Phe Thr Met Thr Ile 
225                 230                 235                 240 


Ala Leu Glu Leu Cys Asp Arg Ile Asn Val Tyr Gly Met Val Pro Pro 
                245                 250                 255     


Asp Phe Cys Arg Asp Pro Asn His Pro Ser Val Pro Tyr His Tyr Tyr 
            260                 265                 270         


Glu Pro Phe Gly Pro Asp Glu Cys Thr Met Tyr Leu Ser His Glu Arg 
        275                 280                 285             


Gly Arg Lys Gly Ser His His Arg Phe Ile Thr Glu Lys Arg Val Phe 
    290                 295                 300                 


Lys Asn Trp Ala Arg Thr Phe Asn Ile His Phe Phe Gln Pro Asp Trp 
305                 310                 315                 320 


Lys Pro Glu Ser Leu Ala Ile Asn His Pro Glu Asn Lys Pro Val Phe 
                325                 330                 335     


<210>  48
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Arg Ser Cys Leu Trp Arg Cys Arg His Leu Ser Gln Gly Val Gln 
1               5                   10                  15      


Trp Ser Leu Leu Leu Ala Val Leu Val Phe Phe Leu Phe Ala Leu Pro 
            20                  25                  30          


Ser Phe Ile Lys Glu Pro Gln Thr Lys Pro Ser Arg His Gln Arg Thr 
        35                  40                  45              


Glu Asn Ile Lys Glu Arg Ser Leu Gln Ser Leu Ala Lys Pro Lys Ser 
    50                  55                  60                  


Gln Ala Pro Thr Arg Ala Arg Arg Thr Thr Ile Tyr Ala Glu Pro Val 
65                  70                  75                  80  


Pro Glu Asn Asn Ala Leu Asn Thr Gln Thr Gln Pro Lys Ala His Thr 
                85                  90                  95      


Thr Gly Asp Arg Gly Lys Glu Ala Asn Gln Ala Pro Pro Glu Glu Gln 
            100                 105                 110         


Asp Lys Val Pro His Thr Ala Gln Arg Ala Ala Trp Lys Ser Pro Glu 
        115                 120                 125             


Lys Glu Lys Thr Met Val Asn Thr Leu Ser Pro Arg Gly Gln Asp Ala 
    130                 135                 140                 


Gly Met Ala Ser Gly Arg Thr Glu Ala Gln Ser Trp Lys Ser Gln Asp 
145                 150                 155                 160 


Thr Lys Thr Thr Gln Gly Asn Gly Gly Gln Thr Arg Lys Leu Thr Ala 
                165                 170                 175     


Ser Arg Thr Val Ser Glu Lys His Gln Gly Lys Ala Ala Thr Thr Ala 
            180                 185                 190         


Lys Thr Leu Ile Pro Lys Ser Gln His Arg Met Leu Ala Pro Thr Gly 
        195                 200                 205             


Ala Val Ser Thr Arg Thr Arg Gln Lys Gly Val Thr Thr Ala Val Ile 
    210                 215                 220                 


Pro Pro Lys Glu Lys Lys Pro Gln Ala Thr Pro Pro Pro Ala Pro Phe 
225                 230                 235                 240 


Gln Ser Pro Thr Thr Gln Arg Asn Gln Arg Leu Lys Ala Ala Asn Phe 
                245                 250                 255     


Lys Ser Glu Pro Arg Trp Asp Phe Glu Glu Lys Tyr Ser Phe Glu Ile 
            260                 265                 270         


Gly Gly Leu Gln Thr Thr Cys Pro Asp Ser Val Lys Ile Lys Ala Ser 
        275                 280                 285             


Lys Ser Leu Trp Leu Gln Lys Leu Phe Leu Pro Asn Leu Thr Leu Phe 
    290                 295                 300                 


Leu Asp Ser Arg His Phe Asn Gln Ser Glu Trp Asp Arg Leu Glu His 
305                 310                 315                 320 


Phe Ala Pro Pro Phe Gly Phe Met Glu Leu Asn Tyr Ser Leu Val Gln 
                325                 330                 335     


Lys Val Val Thr Arg Phe Pro Pro Val Pro Gln Gln Gln Leu Leu Leu 
            340                 345                 350         


Ala Ser Leu Pro Ala Gly Ser Leu Arg Cys Ile Thr Cys Ala Val Val 
        355                 360                 365             


Gly Asn Gly Gly Ile Leu Asn Asn Ser His Met Gly Gln Glu Ile Asp 
    370                 375                 380                 


Ser His Asp Tyr Val Phe Arg Leu Ser Gly Ala Leu Ile Lys Gly Tyr 
385                 390                 395                 400 


Glu Gln Asp Val Gly Thr Arg Thr Ser Phe Tyr Gly Phe Thr Ala Phe 
                405                 410                 415     


Ser Leu Thr Gln Ser Leu Leu Ile Leu Gly Asn Arg Gly Phe Lys Asn 
            420                 425                 430         


Val Pro Leu Gly Lys Asp Val Arg Tyr Leu His Phe Leu Glu Gly Thr 
        435                 440                 445             


Arg Asp Tyr Glu Trp Leu Glu Ala Leu Leu Met Asn Gln Thr Val Met 
    450                 455                 460                 


Ser Lys Asn Leu Phe Trp Phe Arg His Arg Pro Gln Glu Ala Phe Arg 
465                 470                 475                 480 


Glu Ala Leu His Met Asp Arg Tyr Leu Leu Leu His Pro Asp Phe Leu 
                485                 490                 495     


Arg Tyr Met Lys Asn Arg Phe Leu Arg Ser Lys Thr Leu Asp Gly Ala 
            500                 505                 510         


His Trp Arg Ile Tyr Arg Pro Thr Thr Gly Ala Leu Leu Leu Leu Thr 
        515                 520                 525             


Ala Leu Gln Leu Cys Asp Gln Val Ser Ala Tyr Gly Phe Ile Thr Glu 
    530                 535                 540                 


Gly His Glu Arg Phe Ser Asp His Tyr Tyr Asp Thr Ser Trp Lys Arg 
545                 550                 555                 560 


Leu Ile Phe Tyr Ile Asn His Asp Phe Lys Leu Glu Arg Glu Val Trp 
                565                 570                 575     


Lys Arg Leu His Asp Glu Gly Ile Ile Arg Leu Tyr Gln Arg Pro Gly 
            580                 585                 590         


Pro Gly Thr Ala Lys Ala Lys Asn 
        595                 600 


<210>  49
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Cys Ile Leu Lys Arg Lys Ser Val Ile Ala Val Ser Phe Ile 
1               5                   10                  15      


Ala Ala Phe Leu Phe Leu Leu Val Val Arg Leu Val Asn Glu Val Asn 
            20                  25                  30          


Phe Pro Leu Leu Leu Asn Cys Phe Gly Gln Pro Gly Thr Lys Trp Ile 
        35                  40                  45              


Pro Phe Ser Tyr Thr Tyr Arg Arg Pro Leu Arg Thr His Tyr Gly Tyr 
    50                  55                  60                  


Ile Asn Val Lys Thr Gln Glu Pro Leu Gln Leu Asp Cys Asp Leu Cys 
65                  70                  75                  80  


Ala Ile Val Ser Asn Ser Gly Gln Met Val Gly Gln Lys Val Gly Asn 
                85                  90                  95      


Glu Ile Asp Arg Ser Ser Cys Ile Trp Arg Met Asn Asn Ala Pro Thr 
            100                 105                 110         


Lys Gly Tyr Glu Glu Asp Val Gly Arg Met Thr Met Ile Arg Val Val 
        115                 120                 125             


Ser His Thr Ser Val Pro Leu Leu Leu Lys Asn Pro Asp Tyr Phe Phe 
    130                 135                 140                 


Lys Glu Ala Asn Thr Thr Ile Tyr Val Ile Trp Gly Pro Phe Arg Asn 
145                 150                 155                 160 


Met Arg Lys Asp Gly Asn Gly Ile Val Tyr Asn Met Leu Lys Lys Thr 
                165                 170                 175     


Val Gly Ile Tyr Pro Asn Ala Gln Ile Tyr Val Thr Thr Glu Lys Arg 
            180                 185                 190         


Met Ser Tyr Cys Asp Gly Val Phe Lys Lys Glu Thr Gly Lys Asp Arg 
        195                 200                 205             


Val Gln Ser Gly Ser Tyr Leu Ser Thr Gly Trp Phe Thr Phe Leu Leu 
    210                 215                 220                 


Ala Met Asp Ala Cys Tyr Gly Ile His Val Tyr Gly Met Ile Asn Asp 
225                 230                 235                 240 


Thr Tyr Cys Lys Thr Glu Gly Tyr Arg Lys Val Pro Tyr His Tyr Tyr 
                245                 250                 255     


Glu Gln Gly Arg Asp Glu Cys Asp Glu Tyr Phe Leu His Glu His Ala 
            260                 265                 270         


Pro Tyr Gly Gly His Arg Phe Ile Thr Glu Lys Lys Val Phe Ala Lys 
        275                 280                 285             


Trp Ala Lys Lys His Arg Ile Ile Phe Thr His Pro Asn Trp Thr Leu 
    290                 295                 300                 


Ser 
305 


<210>  50
<211>  333
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Cys Ser Arg Pro Pro Ser Gln Cys Glu Pro Thr Ser Leu Pro 
1               5                   10                  15      


Pro Gly Pro Pro Ala Gly Arg Arg His Leu Pro Leu Ser Arg Arg Arg 
            20                  25                  30          


Arg Glu Met Ser Ser Asn Lys Glu Gln Arg Ser Ala Val Phe Val Ile 
        35                  40                  45              


Leu Phe Ala Leu Ile Thr Ile Leu Ile Leu Tyr Ser Ser Asn Ser Ala 
    50                  55                  60                  


Asn Glu Val Phe His Tyr Gly Ser Leu Arg Gly Arg Ser Arg Arg Pro 
65                  70                  75                  80  


Val Asn Leu Lys Lys Trp Ser Ile Thr Asp Gly Tyr Val Pro Ile Leu 
                85                  90                  95      


Gly Asn Lys Thr Leu Pro Ser Arg Cys His Gln Cys Val Ile Val Ser 
            100                 105                 110         


Ser Ser Ser His Leu Leu Gly Thr Lys Leu Gly Pro Glu Ile Glu Arg 
        115                 120                 125             


Ala Glu Cys Thr Ile Arg Met Asn Asp Ala Pro Thr Thr Gly Tyr Ser 
    130                 135                 140                 


Ala Asp Val Gly Asn Lys Thr Thr Tyr Arg Val Val Ala His Ser Ser 
145                 150                 155                 160 


Val Phe Arg Val Leu Arg Arg Pro Gln Glu Phe Val Asn Arg Thr Pro 
                165                 170                 175     


Glu Thr Val Phe Ile Phe Trp Gly Pro Pro Ser Lys Met Gln Lys Pro 
            180                 185                 190         


Gln Gly Ser Leu Val Arg Val Ile Gln Arg Ala Gly Leu Val Phe Pro 
        195                 200                 205             


Asn Met Glu Ala Tyr Ala Val Ser Pro Gly Arg Met Arg Gln Phe Asp 
    210                 215                 220                 


Asp Leu Phe Arg Gly Glu Thr Gly Lys Asp Arg Glu Lys Ser His Ser 
225                 230                 235                 240 


Trp Leu Ser Thr Gly Trp Phe Thr Met Val Ile Ala Val Glu Leu Cys 
                245                 250                 255     


Asp His Val His Val Tyr Gly Met Val Pro Pro Asn Tyr Cys Ser Gln 
            260                 265                 270         


Arg Pro Arg Leu Gln Arg Met Pro Tyr His Tyr Tyr Glu Pro Lys Gly 
        275                 280                 285             


Pro Asp Glu Cys Val Thr Tyr Ile Gln Asn Glu His Ser Arg Lys Gly 
    290                 295                 300                 


Asn His His Arg Phe Ile Thr Glu Lys Arg Val Phe Ser Ser Trp Ala 
305                 310                 315                 320 


Gln Leu Tyr Gly Ile Thr Phe Ser His Pro Ser Trp Thr 
                325                 330             


<210>  51
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Lys Pro His Leu Lys Gln Trp Arg Gln Arg Met Leu Phe Gly Ile 
1               5                   10                  15      


Phe Ala Trp Gly Leu Leu Phe Leu Leu Ile Phe Ile Tyr Phe Thr Asp 
            20                  25                  30          


Ser Asn Pro Ala Glu Pro Val Pro Ser Ser Leu Ser Phe Leu Glu Thr 
        35                  40                  45              


Arg Arg Leu Leu Pro Val Gln Gly Lys Gln Arg Ala Ile Met Gly Ala 
    50                  55                  60                  


Ala His Glu Pro Ser Pro Pro Gly Gly Leu Asp Ala Arg Gln Ala Leu 
65                  70                  75                  80  


Pro Arg Ala His Pro Ala Gly Ser Phe His Ala Gly Pro Gly Asp Leu 
                85                  90                  95      


Gln Lys Trp Ala Gln Ser Gln Asp Gly Phe Glu His Lys Glu Phe Phe 
            100                 105                 110         


Ser Ser Gln Val Gly Arg Lys Ser Gln Ser Ala Phe Tyr Pro Glu Asp 
        115                 120                 125             


Asp Asp Tyr Phe Phe Ala Ala Gly Gln Pro Gly Trp His Ser His Thr 
    130                 135                 140                 


Gln Gly Thr Leu Gly Phe Pro Ser Pro Gly Glu Pro Gly Pro Arg Glu 
145                 150                 155                 160 


Gly Ala Phe Pro Ala Ala Gln Val Gln Arg Arg Arg Val Lys Lys Arg 
                165                 170                 175     


His Arg Arg Gln Arg Arg Ser His Val Leu Glu Glu Gly Asp Asp Gly 
            180                 185                 190         


Asp Arg Leu Tyr Ser Ser Met Ser Arg Ala Phe Leu Tyr Arg Leu Trp 
        195                 200                 205             


Lys Gly Asn Val Ser Ser Lys Met Leu Asn Pro Arg Leu Gln Lys Ala 
    210                 215                 220                 


Met Lys Asp Tyr Leu Thr Ala Asn Lys His Gly Val Arg Phe Arg Gly 
225                 230                 235                 240 


Lys Arg Glu Ala Gly Leu Ser Arg Ala Gln Leu Leu Cys Gln Leu Arg 
                245                 250                 255     


Ser Arg Ala Arg Val Arg Thr Leu Asp Gly Thr Glu Ala Pro Phe Ser 
            260                 265                 270         


Ala Leu Gly Trp Arg Arg Leu Val Pro Ala Val Pro Leu Ser Gln Leu 
        275                 280                 285             


His Pro Arg Gly Leu Arg Ser Cys Ala Val Val Met Ser Ala Gly Ala 
    290                 295                 300                 


Ile Leu Asn Ser Ser Leu Gly Glu Glu Ile Asp Ser His Asp Ala Val 
305                 310                 315                 320 


Leu Arg Phe Asn Ser Ala Pro Thr Arg Gly Tyr Glu Lys Asp Val Gly 
                325                 330                 335     


Asn Lys Thr Thr Ile Arg Ile Ile Asn Ser Gln Ile Leu Thr Asn Pro 
            340                 345                 350         


Ser His His Phe Ile Asp Ser Ser Leu Tyr Lys Asp Val Ile Leu Val 
        355                 360                 365             


Ala Trp Asp Pro Ala Pro Tyr Ser Ala Asn Leu Asn Leu Trp Tyr Lys 
    370                 375                 380                 


Lys Pro Asp Tyr Asn Leu Phe Thr Pro Tyr Ile Gln His Arg Gln Arg 
385                 390                 395                 400 


Asn Pro Asn Gln Pro Phe Tyr Ile Leu His Pro Lys Phe Ile Trp Gln 
                405                 410                 415     


Leu Trp Asp Ile Ile Gln Glu Asn Thr Lys Glu Lys Ile Gln Pro Asn 
            420                 425                 430         


Pro Pro Ser Ser Gly Phe Ile Gly Ile Leu Ile Met Met Ser Met Cys 
        435                 440                 445             


Arg Glu Val His Val Tyr Glu Tyr Ile Pro Ser Val Arg Gln Thr Glu 
    450                 455                 460                 


Leu Cys His Tyr His Glu Leu Tyr Tyr Asp Ala Ala Cys Thr Leu Gly 
465                 470                 475                 480 


Ala Tyr His Pro Leu Leu Tyr Glu Lys Leu Leu Val Gln Arg Leu Asn 
                485                 490                 495     


Met Gly Thr Gln Gly Asp Leu His Arg Lys Gly Lys Val Val Leu Pro 
            500                 505                 510         


Gly Phe Gln Ala Val His Cys Pro Ala Pro Ser Pro Val Ile Pro His 
        515                 520                 525             


Ser 
    


<210>  52
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ile His Thr Asn Leu Lys Lys Lys Phe Ser Cys Cys Val Leu Val 
1               5                   10                  15      


Phe Leu Leu Phe Ala Val Ile Cys Val Trp Lys Glu Lys Lys Lys Gly 
            20                  25                  30          


Ser Tyr Tyr Asp Ser Phe Lys Leu Gln Thr Lys Glu Phe Gln Val Leu 
        35                  40                  45              


Lys Ser Leu Gly Lys Leu Ala Met Gly Ser Asp Ser Gln Ser Val Ser 
    50                  55                  60                  


Ser Ser Ser Thr Gln Asp Pro His Arg Gly Arg Gln Thr Leu Gly Ser 
65                  70                  75                  80  


Leu Arg Gly Leu Ala Lys Ala Lys Pro Glu Ala Ser Phe Gln Val Trp 
                85                  90                  95      


Asn Lys Asp Ser Ser Ser Lys Asn Leu Ile Pro Arg Leu Gln Lys Ile 
            100                 105                 110         


Trp Lys Asn Tyr Leu Ser Met Asn Lys Tyr Lys Val Ser Tyr Lys Gly 
        115                 120                 125             


Pro Gly Pro Gly Ile Lys Phe Ser Ala Glu Ala Leu Arg Cys His Leu 
    130                 135                 140                 


Arg Asp His Val Asn Val Ser Met Val Glu Val Thr Asp Phe Pro Phe 
145                 150                 155                 160 


Asn Thr Ser Glu Trp Glu Gly Tyr Leu Pro Lys Glu Ser Ile Arg Thr 
                165                 170                 175     


Lys Ala Gly Pro Trp Gly Arg Cys Ala Val Val Ser Ser Ala Gly Ser 
            180                 185                 190         


Leu Lys Ser Ser Gln Leu Gly Arg Glu Ile Asp Asp His Asp Ala Val 
        195                 200                 205             


Leu Arg Phe Asn Gly Ala Pro Thr Ala Asn Phe Gln Gln Asp Val Gly 
    210                 215                 220                 


Thr Lys Thr Thr Ile Arg Leu Met Asn Ser Gln Leu Val Thr Thr Glu 
225                 230                 235                 240 


Lys Arg Phe Leu Lys Asp Ser Leu Tyr Asn Glu Gly Ile Leu Ile Val 
                245                 250                 255     


Trp Asp Pro Ser Val Tyr His Ser Asp Ile Pro Lys Trp Tyr Gln Asn 
            260                 265                 270         


Pro Asp Tyr Asn Phe Phe Asn Asn Tyr Lys Thr Tyr Arg Lys Leu His 
        275                 280                 285             


Pro Asn Gln Pro Phe Tyr Ile Leu Lys Pro Gln Met Pro Trp Glu Leu 
    290                 295                 300                 


Trp Asp Ile Leu Gln Glu Ile Ser Pro Glu Glu Ile Gln Pro Asn Pro 
305                 310                 315                 320 


Pro Ser Ser Gly Met Leu Gly Ile Ile Ile Met Met Thr Leu Cys Asp 
                325                 330                 335     


Gln Val Asp Ile Tyr Glu Phe Leu Pro Ser Lys Arg Lys Thr Asp Val 
            340                 345                 350         


Cys Tyr Tyr Tyr Gln Lys Phe Phe Asp Ser Ala Cys Thr Met Gly Ala 
        355                 360                 365             


Tyr His Pro Leu Leu Tyr Glu Lys Asn Leu Val Lys His Leu Asn Gln 
    370                 375                 380                 


Gly Thr Asp Glu Asp Ile Tyr Leu Leu Gly Lys Ala Thr Leu Pro Gly 
385                 390                 395                 400 


Phe Arg Thr Ile His Cys 
                405     


<210>  53
<211>  377
<212>  PRT
<213>  Neisseria meningitides

<400>  53

Met Lys Arg Ile Leu Cys Ile Thr Gly Thr Arg Ala Asp Phe Gly Lys 
1               5                   10                  15      


Leu Lys Pro Leu Leu Ala Tyr Ile Glu Asn His Pro Asp Leu Glu Leu 
            20                  25                  30          


His Leu Ile Val Thr Gly Met His Met Met Lys Thr Tyr Gly Arg Thr 
        35                  40                  45              


Tyr Lys Glu Val Thr Arg Glu Asn Tyr Gln His Thr Tyr Leu Phe Ser 
    50                  55                  60                  


Asn Gln Ile Gln Gly Glu Pro Met Gly Ala Val Leu Gly Asn Thr Ile 
65                  70                  75                  80  


Thr Phe Ile Ser Arg Leu Ser Asp Glu Ile Glu Pro Asp Met Val Met 
                85                  90                  95      


Ile His Gly Asp Arg Leu Glu Ala Leu Ala Gly Ala Ala Val Gly Ala 
            100                 105                 110         


Leu Ser Ser Arg Leu Val Cys His Ile Glu Gly Gly Glu Leu Ser Gly 
        115                 120                 125             


Thr Val Asp Asp Ser Ile Arg His Ser Ile Ser Lys Leu Ser His Ile 
    130                 135                 140                 


His Leu Val Ala Asn Glu Gln Ala Val Thr Arg Leu Val Gln Met Gly 
145                 150                 155                 160 


Glu Lys Arg Lys His Ile His Ile Ile Gly Ser Pro Asp Leu Asp Val 
                165                 170                 175     


Met Ala Ser Ser Thr Leu Pro Ser Leu Glu Glu Val Lys Glu Tyr Tyr 
            180                 185                 190         


Gly Leu Pro Tyr Glu Asn Tyr Gly Ile Ser Met Phe His Pro Val Thr 
        195                 200                 205             


Thr Glu Ala His Leu Met Pro Gln Tyr Ala Ala Gln Tyr Phe Lys Ala 
    210                 215                 220                 


Leu Glu Leu Ser Gly Gln Asn Ile Ile Ser Ile Tyr Pro Asn Asn Asp 
225                 230                 235                 240 


Thr Gly Thr Glu Ser Ile Leu Gln Glu Leu Leu Lys Tyr Gln Ser Asp 
                245                 250                 255     


Lys Phe Ile Ala Phe Pro Ser Ile Arg Phe Glu Tyr Phe Leu Val Leu 
            260                 265                 270         


Leu Lys His Ala Lys Phe Met Val Gly Asn Ser Ser Ala Gly Ile Arg 
        275                 280                 285             


Glu Ala Pro Leu Tyr Gly Val Pro Ser Ile Asp Val Gly Thr Arg Gln 
    290                 295                 300                 


Ser Asn Arg His Met Gly Lys Ser Ile Ile His Thr Asp Tyr Glu Thr 
305                 310                 315                 320 


Lys Asn Ile Phe Asp Ala Ile Gln Gln Ala Cys Ser Leu Gly Lys Phe 
                325                 330                 335     


Glu Ala Asp Asp Thr Phe Asn Gly Gly Asp Thr Arg Thr Ser Thr Glu 
            340                 345                 350         


Arg Phe Ala Glu Val Ile Asn Asn Pro Glu Thr Trp Asn Val Ser Ala 
        355                 360                 365             


Gln Lys Arg Phe Ile Asp Leu Asn Leu 
    370                 375         


<210>  54
<211>  228
<212>  PRT
<213>  Neisseria meningitides

<400>  54

Met Glu Lys Gln Asn Ile Ala Val Ile Leu Ala Arg Gln Asn Ser Lys 
1               5                   10                  15      


Gly Leu Pro Leu Lys Asn Leu Arg Lys Met Asn Gly Ile Ser Leu Leu 
            20                  25                  30          


Gly His Thr Ile Asn Ala Ala Ile Ser Ser Lys Cys Phe Asp Arg Ile 
        35                  40                  45              


Ile Val Ser Thr Asp Gly Gly Leu Ile Ala Glu Glu Ala Lys Asn Phe 
    50                  55                  60                  


Gly Val Glu Val Val Leu Arg Pro Ala Glu Leu Ala Ser Asp Thr Ala 
65                  70                  75                  80  


Ser Ser Ile Ser Gly Val Ile His Ala Leu Glu Thr Ile Gly Ser Asn 
                85                  90                  95      


Ser Gly Thr Val Thr Leu Leu Gln Pro Thr Ser Pro Leu Arg Thr Gly 
            100                 105                 110         


Ala His Ile Arg Glu Ala Phe Ser Leu Phe Asp Glu Lys Ile Lys Gly 
        115                 120                 125             


Ser Val Val Ser Ala Cys Pro Met Glu His His Pro Leu Lys Thr Leu 
    130                 135                 140                 


Leu Gln Ile Asn Asn Gly Glu Tyr Ala Pro Met Arg His Leu Ser Asp 
145                 150                 155                 160 


Leu Glu Gln Pro Arg Gln Gln Leu Pro Gln Ala Phe Arg Pro Asn Gly 
                165                 170                 175     


Ala Ile Tyr Ile Asn Asp Thr Ala Ser Leu Ile Ala Asn Asn Cys Phe 
            180                 185                 190         


Phe Ile Ala Pro Thr Lys Leu Tyr Ile Met Ser His Gln Asp Ser Ile 
        195                 200                 205             


Asp Ile Asp Thr Glu Leu Asp Leu Gln Gln Ala Glu Asn Ile Leu Asn 
    210                 215                 220                 


His Lys Glu Ser 
225             


<210>  55
<211>  349
<212>  PRT
<213>  Neisseria meningitides

<400>  55

Met Gln Asn Asn Asn Glu Phe Lys Ile Gly Asn Arg Ser Val Gly Tyr 
1               5                   10                  15      


Asn His Glu Pro Leu Ile Ile Cys Glu Ile Gly Ile Asn His Glu Gly 
            20                  25                  30          


Ser Leu Lys Thr Ala Phe Glu Met Val Asp Ala Ala Tyr Asn Ala Gly 
        35                  40                  45              


Ala Glu Val Val Lys His Gln Thr His Ile Val Glu Asp Glu Met Ser 
    50                  55                  60                  


Asp Glu Ala Lys Gln Val Ile Pro Gly Asn Ala Asp Val Ser Ile Tyr 
65                  70                  75                  80  


Glu Ile Met Glu Arg Cys Ala Leu Asn Glu Glu Asp Glu Ile Lys Leu 
                85                  90                  95      


Lys Glu Tyr Val Glu Ser Lys Gly Met Ile Phe Ile Ser Thr Pro Phe 
            100                 105                 110         


Ser Arg Ala Ala Ala Leu Arg Leu Gln Arg Met Asp Ile Pro Ala Tyr 
        115                 120                 125             


Lys Ile Gly Ser Gly Glu Cys Asn Asn Tyr Pro Leu Ile Lys Leu Val 
    130                 135                 140                 


Ala Ser Phe Gly Lys Pro Ile Ile Leu Ser Thr Gly Met Asn Ser Ile 
145                 150                 155                 160 


Glu Ser Ile Lys Lys Ser Val Glu Ile Ile Arg Glu Ala Gly Val Pro 
                165                 170                 175     


Tyr Ala Leu Leu His Cys Thr Asn Ile Tyr Pro Thr Pro Tyr Glu Asp 
            180                 185                 190         


Val Arg Leu Gly Gly Met Asn Asp Leu Ser Glu Ala Phe Pro Asp Ala 
        195                 200                 205             


Ile Ile Gly Leu Ser Asp His Thr Leu Asp Asn Tyr Ala Cys Leu Gly 
    210                 215                 220                 


Ala Val Ala Leu Gly Gly Ser Ile Leu Glu Arg His Phe Thr Asp Arg 
225                 230                 235                 240 


Met Asp Arg Pro Gly Pro Asp Ile Val Cys Ser Met Asn Pro Asp Thr 
                245                 250                 255     


Phe Lys Glu Leu Lys Gln Gly Ala His Ala Leu Lys Leu Ala Arg Gly 
            260                 265                 270         


Gly Lys Lys Asp Thr Ile Ile Ala Gly Glu Lys Pro Thr Lys Asp Phe 
        275                 280                 285             


Ala Phe Ala Ser Val Val Ala Asp Lys Asp Ile Lys Lys Gly Glu Leu 
    290                 295                 300                 


Leu Ser Gly Asp Asn Leu Trp Val Lys Arg Pro Gly Asn Gly Asp Phe 
305                 310                 315                 320 


Ser Val Asn Glu Tyr Glu Thr Leu Phe Gly Lys Val Ala Ala Cys Asn 
                325                 330                 335     


Ile Arg Lys Gly Ala Gln Ile Lys Lys Thr Asp Ile Glu 
            340                 345                 


<210>  56
<211>  10475
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Operon OGO-3

<400>  56
cggtacatgt tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga       60

aaggttttgc gccattcgat ggtgtcctgg cacgacaggt ttcccgactg gaaagcgggc      120

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac      180

tttatgcttc cggctcgtat aatgtgtgga attgtgagcg gataacaatt tcacacagga      240

aacaggatcg atccatcgat gagcttactc cccatccccc tgttgacaat taatcatcgg      300

ctcgtataat gtgtggaatt gtgagcggat aacaatttca cacaggaaac aggatcagct      360

tactccccat ccccctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag      420

cggataacaa tttcacacag gaaacaggat ccatcgatgc ttaggaggtc agatgaaaat      480

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga      540

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa      600

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg      660

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga      720

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa      780

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct      840

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa      900

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc      960

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     1020

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     1080

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     1140

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     1200

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     1260

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     1320

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     1380

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     1440

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     1500

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     1560

agacgcgcag actaattcga gctcgaacaa caacaacaat aacaataaca acaacctcgg     1620

gatcgaggga aggatttcag agttcggttc caaaaagaaa gaccttcatc acagcaatgg     1680

agaagagaaa gcacaaagca tggagaccct ccctccaggg aaagtacggt ggccagactt     1740

taaccaggaa gcttatgttg gagggacgat ggtccgctcc gggcaggacc cttacgcccg     1800

caacaagttc aaccaggtgg agagtgataa gcttcgaatg gacagagcca tccctgacac     1860

ccggcatgac cagtgtcagc ggaagcagtg gcgggtggat ctgccggcca ccagcgtggt     1920

gatcacgttt cacaatgaag ccaggtcggc cctactcagg accgtggtca gcgtgcttaa     1980

gaaaagcccg ccccatctca taaaagaaat catcttggtg gatgactaca gcaatgatcc     2040

tgaggacggg gctctcttgg ggaaaattga gaaagtgcga gttcttagaa atgatcgacg     2100

agaaggcctc atgcgctcac gggttcgggg ggccgatgct gcccaagcca aggtcctgac     2160

cttcctggac agtcactgcg agtgtaatga gcactggctg gagcccctcc tggaaagggt     2220

ggcggaggac aggactcggg ttgtgtcacc catcatcgat gtcattaata tggacaactt     2280

tcagtatgtg ggggcatctg ctgacttgaa gggcggtttt gattggaact tggtattcaa     2340

gtgggattac atgacgcctg agcagagaag gtcccggcag gggaacccag tcgcccctat     2400

aaaaaccccc atgattgctg gtgggctgtt tgtgatggat aagttctatt ttgaagaact     2460

ggggaagtac gacatgatga tggatgtgtg gggaggagag aacctagaga tctcgttccg     2520

cgtgtggcag tgtggtggca gcctggagat catcccgtgc agccgtgtgg gacacgtgtt     2580

ccggaagcag cacccctaca cgttcccggg tggcagtggc actgtctttg cccgaaacac     2640

ccgccgggca gcagaggtct ggatggatga atacaaaaat ttctattatg cagcagtgcc     2700

ttctgctaga aacgttcctt atggaaatat tcagagcaga ttggagctta ggaagaaact     2760

cagctgcaag cctttcaaat ggtaccttga aaatgtctat ccagagttaa gggttccaga     2820

ccatcaggat atagcttttg gggccttgca gcagggaact aactgcctcg acactttggg     2880

acactttgct gatggtgtgg ttggagttta tgaatgtcac aatgctgggg gaaaccagga     2940

atgggccttg acgaaggaga agtcggtgaa gcacatggat ttgtgcctta ctgtggtgga     3000

ccgggcaccg ggctctctta taaagctgca gggctgccga gaaaatgaca gcagacagaa     3060

atgggaacag atcgagggca actccaagct gaggcacgtg ggcagcaacc tgtgcctgga     3120

cagtcgcacg gccaagagcg ggggcctaag cgtggaggtg tgtggcccgg ccctttcgca     3180

gcagtggaag ttcacgctca acctgcagca gtagtctaga aggaggtatt atgaaaattc     3240

ttattagcgg tggtgcaggt tatataggtt ctcatacttt aagacaattt ttaaaaacag     3300

atcatgaaat ttgtgtttta gataatcttt ctaagggttc taaaatcgca atagaagatt     3360

tgcaaaaaac aagagctttt aaatttttcg aacaagattt aagtgatttt caaggcgtaa     3420

aagcattgtt tgagagagaa aaatttgacg ctattgtgca ttttgcagca agcattgaag     3480

tttttgaaag tatgcaaaat cctttaaaat attatatgaa caacactgtt aatacgacaa     3540

atctcatcga aacttgtttg caaactggag tgaataaatt tatattttct tcaacggcgg     3600

ccacttatgg cgaaccacaa actcccgttg tgagcgaaac aagtccttta gcacctatta     3660

atccttatgg gcgtagtaag cttatgagtg aagaagtttt gcgtgatgca agtatggcaa     3720

atcctgaatt taagcattgt attttaagat attttaatgt tgcaggtgct tgtatggatt     3780

atactttagg acaacgctat ccaaaagcga ctttgcttat aaaagttgca gctgaatgtg     3840

ccgcaggaaa acgtgataaa cttttcatat ttggcgatga ttatgataca aaagatggta     3900

cttgcataag agattttatc catgtagatg atatttcaag tgcacattta gcggctttgg     3960

attatttaaa agagaatgaa agcaatgttt ttaatgtagg ttatggacat ggttttagcg     4020

taaaagaagt gattgaagcg atgaaaaaag ttagcggagt ggattttaaa gtagaacttg     4080

ccccacgccg tgcgggtgat cctagtgtat tgatttctga tgcaagtaaa atcagaaatc     4140

ttacttcttg gcagcctaaa tatgatgatt tagagcttat ttgtaaatct gcttttgatt     4200

gggaaaaaca gtgttaataa gcatgcggaa acagtcgaca ggaggtatta tggatgatgc     4260

ggcgattcag cagaccctgg ccaaaatggg cattaaaagc agcgatattc agccggcacc     4320

ggtggcgggt atgaaaaccg tgctgaccaa cagcggcgtg ctgtatatca ccgatgatgg     4380

caaacatatc attcagggcc cgatgtatga tgtgagcggc accgcaccgg tgaacgtgac     4440

caacaaaatg ctgctgaaac agctgaacgc gctggaaaaa gaaatgatcg tgtataaagc     4500

gccgcaggaa aaacacgtta ttaccgtgtt taccgatatt acctgcggct attgccataa     4560

actgcatgag caaatggcgg attataacgc gctgggcatt accgtgcgtt atctggcctt     4620

tccgcgtcag ggcctggata gcgatgccga aaaggaaatg aaagcgatct ggtgcgcgaa     4680

agataaaaac aaagcgttcg atgatgtgat ggcgggcaaa agcgttgcgc cggcgagctg     4740

tgatgtggat attgcggatc attatgcgct gggcgtgcag ctgggtgtta gcggcacccc     4800

ggcggtggtt ctgagcaacg gcaccctggt gccgggttat cagccgccga aagagatgaa     4860

agaatttctg gatgaacacc agaaaatgac cagcggcaaa taatggcaaa tattctgaaa     4920

tgagctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag cggataacaa     4980

tttcacacag gaaacagcca gtccgtttag gtgttttcac gagcaattga ccaacaagga     5040

ccatagatta tgaaaatcga agaaggtaaa ctggtaatct ggattaacgg cgataaaggc     5100

tataacggtc tcgctgaagt cggtaagaaa ttcgagaaag ataccggaat taaagtcacc     5160

gttgagcatc cggataaact ggaagagaaa ttcccacagg ttgcggcaac tggcgatggc     5220

cctgacatta tcttctgggc acacgaccgc tttggtggct acgctcaatc tggcctgttg     5280

gctgaaatca ccccggacaa agcgttccag gacaagctgt atccgtttac ctgggatgcc     5340

gtacgttaca acggcaagct gattgcttac ccgatcgctg ttgaagcgtt atcgctgatt     5400

tataacaaag atctgctgcc gaacccgcca aaaacctggg aagagatccc ggcgctggat     5460

aaagaactga aagcgaaagg taagagcgcg ctgatgttca acctgcaaga accgtacttc     5520

acctggccgc tgattgctgc tgacgggggt tatgcgttca agtatgaaaa cggcaagtac     5580

gacattaaag acgtgggcgt ggataacgct ggcgcgaaag cgggtctgac cttcctggtt     5640

gacctgatta aaaacaaaca catgaatgca gacaccgatt actccatcgc agaagctgcc     5700

tttaataaag gcgaaacagc gatgaccatc aacggcccgt gggcatggtc caacatcgac     5760

accagcaaag tgaattatgg tgtaacggta ctgccgacct tcaagggtca accatccaaa     5820

ccgttcgttg gcgtgctgag cgcaggtatt aacgccgcca gtccgaacaa agagctggca     5880

aaagagttcc tcgaaaacta tctgctgact gatgaaggtc tggaagcggt taataaagac     5940

aaaccgctgg gtgccgtagc gctgaagtct tacgaggaag agttggtgaa agatccgcgt     6000

attgccgcca ctatggaaaa cgcccagaaa ggtgaaatca tgccgaacat cccgcagatg     6060

tccgctttct ggtatgccgt gcgtactgcg gtgatcaacg ccgccagcgg tcgtcagact     6120

gtcgatgaag ccctgaaaga cgcgcagact aattcgagct cgaacaacaa caacaataac     6180

aataacaaca acctcgggat cgagggaagg atttcacata tgcgcccatg cacatgcact     6240

cgctgtattg aagagcaacg cgtatccgcc tggtttgatg aacgttttaa tcgctccatg     6300

cagcctctgt taaccgctaa aaacgcccat ttagaagaag atacctataa gtggtggctc     6360

cgcctgcaac gtgaaaaaca acccaacaac cttaacgaca ccattcgcga actgttccag     6420

gtagttcccg gtaatgtgga cccactgttg gaaaaacgtc ttgtttcatg tcgtcgttgc     6480

gccgtagttg gcaactcagg taaccttaaa gaaagctatt atggaccaca aattgattct     6540

catgatttcg tattacgcat gaataaagcc cccacagaag gtttcgaagc tgacgttggc     6600

agtaaaacaa cccaccattt tgtataccct gaatcctttc gcgaacttgc ccaagaagtt     6660

tctatgatcc ttgtaccgtt taaaactact gatctcgaat gggtcatttc agcaactact     6720

accggtcgca tttcccacac ctacgttcct gtacctgcca aaattaaagt caaaaaagaa     6780

aaaattttaa tctaccaccc agcatttatt aaatacgtgt ttgaccgttg gcttcaaggt     6840

cacggccgtt atccatccac cggcatctta agcgtaattt tttcactcca catctgcgat     6900

gaagtcgatc tctacggttt cggggccgat tcaaaaggaa actggcatca ctattgggaa     6960

aataatcctt cagctggcgc atttcgtaaa actggagttc atgatggaga tttcgaaagc     7020

aatgtgacca ccattttagc cagtattaat aagattcgca tttttaaagg tcgctaagat     7080

ccatcgatgc ttaggaggtc atatgatgtt taaaatttca atcatcttac caacttataa     7140

tgtggaacaa tatatagcaa gggcaataga aagctgtatc aatcagactt ttaaagatat     7200

agaaataatt gtagttgatg attgtggaaa tgataatagt ataaatatag ccaaagaata     7260

ctctaaaaaa gacaaaagaa taaaaataat ccacaatgaa aaaaacttag gtcttttaag     7320

agcaagatat gaaggtgtga aagtagcaaa ctctccttat ataatgtttt tagatcctga     7380

tgattatttg gaactaaatg cttgtgaaga gtgtataaaa attttagatg aacaggatga     7440

agttgattta gtgtttttca atgctattgt tgaaagtaat gttatttcat ataaaaagtt     7500

tgactttaat tctggttttt atagcaaaaa agagtttgta aaaaaaatta ttgcaaagaa     7560

aaatttatat tggactatgt gggggaaact tataagaaag aaattgtatt tagaagcttt     7620

tgcgagttta agactcgaga aagatgttaa aatcaatatg gctgaagatg tattgttata     7680

ttatccaatg ttaagtcaag ctcaaaaaat agcatatatg aactgtaatt tatatcatta     7740

cgtgcctaat aataattcaa tttgtaatac taagaatgaa gtgcttgtta aaaataatat     7800

tcaagagttg cagttggttt taaactattt aaggcaaaat tatattttaa acaagtattg     7860

tagcgttctc tatgtgctaa ttaaatattt gctatatatt caaatatata aaataaaacc     7920

gtgagaattc cctgatcgat gataagctgt caaacatgag cagatctgag cccgcctaat     7980

gagcgggctt ttttttcaga tctgcttgaa gacgaaaggg cctcgtgata cggagctcga     8040

attcactggc cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta     8100

atcgccttgc agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg     8160

atcgcccttc ccaacagttg cgcagcctga atggcgaatg gcgcctgatg cggtattttc     8220

tccttacgca tctgtgcggt atttcacacc gcatctggtg cactctcagt acaatctgct     8280

ctgatgccgc atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac     8340

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     8400

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac     8460

gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca atattttatc     8520

tgattaataa gatgatcttc ttgagatcgt tttggtctgc gcgtaatctc ttgctctgaa     8580

aacgaaaaaa ccgccttgca gggcggtttt tcgaaggttc tctgagctac caactctttg     8640

aaccgaggta actggcttgg aggagcgcag tcaccaaaac ttgtcctttc agtttagcct     8700

taaccggcgc atgacttcaa gactaactcc tctaaatcaa ttaccagtgg ctgctgccag     8760

tggtgctttt gcatgtcttt ccgggttgga ctcaagacga tagttaccgg ataaggcgca     8820

gcggtcggac tgaacggggg gttcgtgcat acagtccagc ttggagcgaa ctgcctaccc     8880

ggaactgagt gtcaggcgtg gaatgagaca aacgcggcca taacagcgga atgacaccgg     8940

taaaccgaaa ggcaggaaca ggagagcgca cgagggagcc gccaggggga aacgcctggt     9000

atctttatag tcctgtcggg tttcgccacc actgatttga gcgtcagatt tcgtgatgct     9060

tgtcaggggg gcggagccta tggaaaaacg gctttgccgc ggccctctca cttccctgtt     9120

aagtatcttc ctggcatctt ccaggaaatc tccgccccgt tcgtaagcca tttccgctcg     9180

ccgcagtcga acgaccgagc gtagcgagtc agtgagcgag gaagcggaat atatcctgta     9240

tcacatattc tgctgacgca ccggtgcagc cttttttctc ctgccacatg aagcacttca     9300

ctgacaccct catcagtgcc aacatagtaa gccagtatac actccgctag cgctgatgtc     9360

cggcggtgct tttgccgtta cgcaccaccc cgtcagtagc tgaacaggag ggacagctga     9420

tagaaacaga agccactgga gcacctcaaa aacaccatca tacactaaat cagtaagttg     9480

gcagcatcac ccgacgcact ttgcgccgaa taaatacctg tgacggaaga tcacttcgca     9540

gaataaataa atcctggtgt ccctgttgat accgggaagc cctgggccaa cttttggcga     9600

aaatgagacg ttgatcggca cgtaagaggt tccaactttc accataatga aataagatca     9660

ctaccgggcg tattttttga gttatcgaga ttttcaggag ctaaggaagc taaaatggag     9720

aaaaaaatca ctggatatac caccgttgat atatcccaat ggcatcgtaa agaacatttt     9780

gaggcatttc agtcagttgc tcaatgtacc tataaccaga ccgttcagct ggatattacg     9840

gcctttttaa agaccgtaaa gaaaaataag cacaagtttt atccggcctt tattcacatt     9900

cttgcccgcc tgatgaatgc tcatccggaa ttccgtatgg caatgaaaga cggtgagctg     9960

gtgatatggg atagtgttca cccttgttac accgttttcc atgagcaaac tgaaacgttt    10020

tcatcgctct ggagtgaata ccacgacgat ttccggcagt ttctacacat atattcgcaa    10080

gatgtggcgt gttacggtga aaacctggcc tatttcccta aagggtttat tgagaatatg    10140

tttttcgtct cagccaatcc ctgggtgagt ttcaccagtt ttgatttaaa cgtggccaat    10200

atggacaact tcttcgcccc cgttttcacc atgggcaaat attatacgca aggcgacaag    10260

gtgctgatgc cgctggcgat tcaggttcat catgccgtct gtgatggctt ccatgtcggc    10320

agaatgctta atgaattaca acagtactgc gatgagtggc agggcggggc gtaatttttt    10380

taaggcagtt attggtgccc ttaaacgcct ggtgctacgc ctgaataagt gataataagc    10440

ggatgaatgg cagaaattcg aaagcaaatt cgacc                               10475


<210>  57
<211>  9368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Operon OGO-4

<400>  57
cggtacatgt tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga       60

aaggttttgc gccattcgat ggtgtcctgg cacgacaggt ttcccgactg gaaagcgggc      120

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac      180

tttatgcttc cggctcgtat aatgtgtgga attgtgagcg gataacaatt tcacacagga      240

aacaggatcg atccatcgat gagcttactc cccatccccc tgttgacaat taatcatcgg      300

ctcgtataat gtgtggaatt gtgagcggat aacaatttca cacaggaaac aggatcagct      360

tactccccat ccccctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag      420

cggataacaa tttcacacag gaaacaggat ccatcgatgc ttaggaggtc agatgaaaat      480

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga      540

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa      600

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg      660

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga      720

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa      780

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct      840

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa      900

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc      960

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     1020

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     1080

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     1140

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     1200

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     1260

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     1320

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     1380

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     1440

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     1500

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     1560

agacgcgcag actaattcga gctcgaacaa caacaacaat aacaataaca acaacctcgg     1620

gatcgaggga aggatttcag agttcggttc caaaaagaaa gaccttcatc acagcaatgg     1680

agaagagaaa gcacaaagca tggagaccct ccctccaggg aaagtacggt ggccagactt     1740

taaccaggaa gcttatgttg gagggacgat ggtccgctcc gggcaggacc cttacgcccg     1800

caacaagttc aaccaggtgg agagtgataa gcttcgaatg gacagagcca tccctgacac     1860

ccggcatgac cagtgtcagc ggaagcagtg gcgggtggat ctgccggcca ccagcgtggt     1920

gatcacgttt cacaatgaag ccaggtcggc cctactcagg accgtggtca gcgtgcttaa     1980

gaaaagcccg ccccatctca taaaagaaat catcttggtg gatgactaca gcaatgatcc     2040

tgaggacggg gctctcttgg ggaaaattga gaaagtgcga gttcttagaa atgatcgacg     2100

agaaggcctc atgcgctcac gggttcgggg ggccgatgct gcccaagcca aggtcctgac     2160

cttcctggac agtcactgcg agtgtaatga gcactggctg gagcccctcc tggaaagggt     2220

ggcggaggac aggactcggg ttgtgtcacc catcatcgat gtcattaata tggacaactt     2280

tcagtatgtg ggggcatctg ctgacttgaa gggcggtttt gattggaact tggtattcaa     2340

gtgggattac atgacgcctg agcagagaag gtcccggcag gggaacccag tcgcccctat     2400

aaaaaccccc atgattgctg gtgggctgtt tgtgatggat aagttctatt ttgaagaact     2460

ggggaagtac gacatgatga tggatgtgtg gggaggagag aacctagaga tctcgttccg     2520

cgtgtggcag tgtggtggca gcctggagat catcccgtgc agccgtgtgg gacacgtgtt     2580

ccggaagcag cacccctaca cgttcccggg tggcagtggc actgtctttg cccgaaacac     2640

ccgccgggca gcagaggtct ggatggatga atacaaaaat ttctattatg cagcagtgcc     2700

ttctgctaga aacgttcctt atggaaatat tcagagcaga ttggagctta ggaagaaact     2760

cagctgcaag cctttcaaat ggtaccttga aaatgtctat ccagagttaa gggttccaga     2820

ccatcaggat atagcttttg gggccttgca gcagggaact aactgcctcg acactttggg     2880

acactttgct gatggtgtgg ttggagttta tgaatgtcac aatgctgggg gaaaccagga     2940

atgggccttg acgaaggaga agtcggtgaa gcacatggat ttgtgcctta ctgtggtgga     3000

ccgggcaccg ggctctctta taaagctgca gggctgccga gaaaatgaca gcagacagaa     3060

atgggaacag atcgagggca actccaagct gaggcacgtg ggcagcaacc tgtgcctgga     3120

cagtcgcacg gccaagagcg ggggcctaag cgtggaggtg tgtggcccgg ccctttcgca     3180

gcagtggaag ttcacgctca acctgcagca gtagtctaga aggaggtatt atgaaaattc     3240

ttattagcgg tggtgcaggt tatataggtt ctcatacttt aagacaattt ttaaaaacag     3300

atcatgaaat ttgtgtttta gataatcttt ctaagggttc taaaatcgca atagaagatt     3360

tgcaaaaaac aagagctttt aaatttttcg aacaagattt aagtgatttt caaggcgtaa     3420

aagcattgtt tgagagagaa aaatttgacg ctattgtgca ttttgcagca agcattgaag     3480

tttttgaaag tatgcaaaat cctttaaaat attatatgaa caacactgtt aatacgacaa     3540

atctcatcga aacttgtttg caaactggag tgaataaatt tatattttct tcaacggcgg     3600

ccacttatgg cgaaccacaa actcccgttg tgagcgaaac aagtccttta gcacctatta     3660

atccttatgg gcgtagtaag cttatgagtg aagaagtttt gcgtgatgca agtatggcaa     3720

atcctgaatt taagcattgt attttaagat attttaatgt tgcaggtgct tgtatggatt     3780

atactttagg acaacgctat ccaaaagcga ctttgcttat aaaagttgca gctgaatgtg     3840

ccgcaggaaa acgtgataaa cttttcatat ttggcgatga ttatgataca aaagatggta     3900

cttgcataag agattttatc catgtagatg atatttcaag tgcacattta gcggctttgg     3960

attatttaaa agagaatgaa agcaatgttt ttaatgtagg ttatggacat ggttttagcg     4020

taaaagaagt gattgaagcg atgaaaaaag ttagcggagt ggattttaaa gtagaacttg     4080

ccccacgccg tgcgggtgat cctagtgtat tgatttctga tgcaagtaaa atcagaaatc     4140

ttacttcttg gcagcctaaa tatgatgatt tagagcttat ttgtaaatct gcttttgatt     4200

gggaaaaaca gtgttaataa gcatgcggaa acagtcgaca ggaggtatta tggatgatgc     4260

ggcgattcag cagaccctgg ccaaaatggg cattaaaagc agcgatattc agccggcacc     4320

ggtggcgggt atgaaaaccg tgctgaccaa cagcggcgtg ctgtatatca ccgatgatgg     4380

caaacatatc attcagggcc cgatgtatga tgtgagcggc accgcaccgg tgaacgtgac     4440

caacaaaatg ctgctgaaac agctgaacgc gctggaaaaa gaaatgatcg tgtataaagc     4500

gccgcaggaa aaacacgtta ttaccgtgtt taccgatatt acctgcggct attgccataa     4560

actgcatgag caaatggcgg attataacgc gctgggcatt accgtgcgtt atctggcctt     4620

tccgcgtcag ggcctggata gcgatgccga aaaggaaatg aaagcgatct ggtgcgcgaa     4680

agataaaaac aaagcgttcg atgatgtgat ggcgggcaaa agcgttgcgc cggcgagctg     4740

tgatgtggat attgcggatc attatgcgct gggcgtgcag ctgggtgtta gcggcacccc     4800

ggcggtggtt ctgagcaacg gcaccctggt gccgggttat cagccgccga aagagatgaa     4860

agaatttctg gatgaacacc agaaaatgac cagcggcaaa taatggcaaa tattctgaaa     4920

tgagctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag cggataacaa     4980

tttcacacag gaaacagcca gtccgtttag gtgttttcac gagcaattga ccaacaagga     5040

ccatagatta tgtttaaaat ttcaatcatc ttaccaactt ataatgtgga acaatatata     5100

gcaagggcaa tagaaagctg tatcaatcag acttttaaag atatagaaat aattgtagtt     5160

gatgattgtg gaaatgataa tagtataaat atagccaaag aatactctaa aaaagacaaa     5220

agaataaaaa taatccacaa tgaaaaaaac ttaggtcttt taagagcaag atatgaaggt     5280

gtgaaagtag caaactctcc ttatataatg tttttagatc ctgatgatta tttggaacta     5340

aatgcttgtg aagagtgtat aaaaatttta gatgaacagg atgaagttga tttagtgttt     5400

ttcaatgcta ttgttgaaag taatgttatt tcatataaaa agtttgactt taattctggt     5460

ttttatagca aaaaagagtt tgtaaaaaaa attattgcaa agaaaaattt atattggact     5520

atgtggggga aacttataag aaagaaattg tatttagaag cttttgcgag tttaagactc     5580

gagaaagatg ttaaaatcaa tatggctgaa gatgtattgt tatattatcc aatgttaagt     5640

caagctcaaa aaatagcata tatgaactgt aatttatatc attacgtgcc taataataat     5700

tcaatttgta atactaagaa tgaagtgctt gttaaaaata atattcaaga gttgcagttg     5760

gttttaaact atttaaggca aaattatatt ttaaacaagt attgtagcgt tctctatgtg     5820

ctaattaaat atttgctata tattcaaata tataaaataa aaccgtgaga attctctaga     5880

aataattttg tttaacttta agaaggagat ataccatgac aaggactaga atggaaaatg     5940

aactcattgt tagtaaaaat atgcaaaata taatcatagc aggaaatgga cctagcctaa     6000

aaaatattaa ttataaaaga ctgcctagag aatatgatgt ttttaggtgt aaccagtttt     6060

attttgaaga taagtattat ttaggaaaaa agattaaagc agtatttttt aatcctggtg     6120

tctttttaca acagtatcac actgcaaaac aacttatact aaaaaatgag tatgaaataa     6180

aaaatatttt ttgctctaca tttaatttac cttttattga aagcaatgat tttttacatc     6240

aattttataa ttttttcccc gatgcaaaac ttggctatga agttattgaa aaccttaaag     6300

aattttatgc ttatataaaa tacaatgaaa tttatttcaa taaaagaatt acttcgggcg     6360

tctatatgtg tgcaattgct attgcattag gatataaaac catctattta tgtggcattg     6420

atttttatga aggagatgtt atttatcctt ttgaagctat gagtacaaat ataaaaacaa     6480

tctttcctgg aataaaagat ttcaaacctt caaattgtca ttctaaggaa tacgatatag     6540

aagcattaaa attgttaaaa tcaatataca aagttaatat ctacgcattg tgtgatgatt     6600

ctattttggc aaatcatttt cctttatcaa ttaatattaa taacaatttc actttagaaa     6660

ataagcataa taattctata aatgatattt tattgactga taatactcct ggcgtaagtt     6720

tttataaaaa tcaacttaaa gctgataata aaattatgct taatttttat aatattcttc     6780

attctaaaga taatttaatt aaatttttaa acaaataagt cgacctgcag aatgataagc     6840

tgtcaaacat gagcagatct gagcccgcct aatgagcggg cttttttttc agatctgctt     6900

gaagacgaaa gggcctcgtg atacggagct cgaattcact ggccgtcgtt ttacaacgtc     6960

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     7020

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     7080

tgaatggcga atggcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac     7140

accgcatctg gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc     7200

gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt     7260

acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac     7320

cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga     7380

taataatggt ttcttagacg tcaatatttt atctgattaa taagatgatc ttcttgagat     7440

cgttttggtc tgcgcgtaat ctcttgctct gaaaacgaaa aaaccgcctt gcagggcggt     7500

ttttcgaagg ttctctgagc taccaactct ttgaaccgag gtaactggct tggaggagcg     7560

cagtcaccaa aacttgtcct ttcagtttag ccttaaccgg cgcatgactt caagactaac     7620

tcctctaaat caattaccag tggctgctgc cagtggtgct tttgcatgtc tttccgggtt     7680

ggactcaaga cgatagttac cggataaggc gcagcggtcg gactgaacgg ggggttcgtg     7740

catacagtcc agcttggagc gaactgccta cccggaactg agtgtcaggc gtggaatgag     7800

acaaacgcgg ccataacagc ggaatgacac cggtaaaccg aaaggcagga acaggagagc     7860

gcacgaggga gccgccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     7920

accactgatt tgagcgtcag atttcgtgat gcttgtcagg ggggcggagc ctatggaaaa     7980

acggctttgc cgcggccctc tcacttccct gttaagtatc ttcctggcat cttccaggaa     8040

atctccgccc cgttcgtaag ccatttccgc tcgccgcagt cgaacgaccg agcgtagcga     8100

gtcagtgagc gaggaagcgg aatatatcct gtatcacata ttctgctgac gcaccggtgc     8160

agcctttttt ctcctgccac atgaagcact tcactgacac cctcatcagt gccaacatag     8220

taagccagta tacactccgc tagcgctgat gtccggcggt gcttttgccg ttacgcacca     8280

ccccgtcagt agctgaacag gagggacagc tgatagaaac agaagccact ggagcacctc     8340

aaaaacacca tcatacacta aatcagtaag ttggcagcat cacccgacgc actttgcgcc     8400

gaataaatac ctgtgacgga agatcacttc gcagaataaa taaatcctgg tgtccctgtt     8460

gataccggga agccctgggc caacttttgg cgaaaatgag acgttgatcg gcacgtaaga     8520

ggttccaact ttcaccataa tgaaataaga tcactaccgg gcgtattttt tgagttatcg     8580

agattttcag gagctaagga agctaaaatg gagaaaaaaa tcactggata taccaccgtt     8640

gatatatccc aatggcatcg taaagaacat tttgaggcat ttcagtcagt tgctcaatgt     8700

acctataacc agaccgttca gctggatatt acggcctttt taaagaccgt aaagaaaaat     8760

aagcacaagt tttatccggc ctttattcac attcttgccc gcctgatgaa tgctcatccg     8820

gaattccgta tggcaatgaa agacggtgag ctggtgatat gggatagtgt tcacccttgt     8880

tacaccgttt tccatgagca aactgaaacg ttttcatcgc tctggagtga ataccacgac     8940

gatttccggc agtttctaca catatattcg caagatgtgg cgtgttacgg tgaaaacctg     9000

gcctatttcc ctaaagggtt tattgagaat atgtttttcg tctcagccaa tccctgggtg     9060

agtttcacca gttttgattt aaacgtggcc aatatggaca acttcttcgc ccccgttttc     9120

accatgggca aatattatac gcaaggcgac aaggtgctga tgccgctggc gattcaggtt     9180

catcatgccg tctgtgatgg cttccatgtc ggcagaatgc ttaatgaatt acaacagtac     9240

tgcgatgagt ggcagggcgg ggcgtaattt ttttaaggca gttattggtg cccttaaacg     9300

cctggtgcta cgcctgaata agtgataata agcggatgaa tggcagaaat tcgaaagcaa     9360

attcgacc                                                              9368


<210>  58
<211>  9308
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Operon OGO-5

<400>  58
cggtacatgt tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga       60

aaggttttgc gccattcgat ggtgtcctgg cacgacaggt ttcccgactg gaaagcgggc      120

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac      180

tttatgcttc cggctcgtat aatgtgtgga attgtgagcg gataacaatt tcacacagga      240

aacaggatcg atccatcgat gagcttactc cccatccccc tgttgacaat taatcatcgg      300

ctcgtataat gtgtggaatt gtgagcggat aacaatttca cacaggaaac aggatcagct      360

tactccccat ccccctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag      420

cggataacaa tttcacacag gaaacaggat ccatcgatgc ttaggaggtc agatgaaaat      480

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga      540

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa      600

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg      660

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga      720

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa      780

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct      840

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa      900

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc      960

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     1020

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     1080

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     1140

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     1200

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     1260

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     1320

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     1380

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     1440

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     1500

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     1560

agacgcgcag actaattcga gctcgaacaa caacaacaat aacaataaca acaacctcgg     1620

gatcgaggga aggatttcag agttcggttc caaaaagaaa gaccttcatc acagcaatgg     1680

agaagagaaa gcacaaagca tggagaccct ccctccaggg aaagtacggt ggccagactt     1740

taaccaggaa gcttatgttg gagggacgat ggtccgctcc gggcaggacc cttacgcccg     1800

caacaagttc aaccaggtgg agagtgataa gcttcgaatg gacagagcca tccctgacac     1860

ccggcatgac cagtgtcagc ggaagcagtg gcgggtggat ctgccggcca ccagcgtggt     1920

gatcacgttt cacaatgaag ccaggtcggc cctactcagg accgtggtca gcgtgcttaa     1980

gaaaagcccg ccccatctca taaaagaaat catcttggtg gatgactaca gcaatgatcc     2040

tgaggacggg gctctcttgg ggaaaattga gaaagtgcga gttcttagaa atgatcgacg     2100

agaaggcctc atgcgctcac gggttcgggg ggccgatgct gcccaagcca aggtcctgac     2160

cttcctggac agtcactgcg agtgtaatga gcactggctg gagcccctcc tggaaagggt     2220

ggcggaggac aggactcggg ttgtgtcacc catcatcgat gtcattaata tggacaactt     2280

tcagtatgtg ggggcatctg ctgacttgaa gggcggtttt gattggaact tggtattcaa     2340

gtgggattac atgacgcctg agcagagaag gtcccggcag gggaacccag tcgcccctat     2400

aaaaaccccc atgattgctg gtgggctgtt tgtgatggat aagttctatt ttgaagaact     2460

ggggaagtac gacatgatga tggatgtgtg gggaggagag aacctagaga tctcgttccg     2520

cgtgtggcag tgtggtggca gcctggagat catcccgtgc agccgtgtgg gacacgtgtt     2580

ccggaagcag cacccctaca cgttcccggg tggcagtggc actgtctttg cccgaaacac     2640

ccgccgggca gcagaggtct ggatggatga atacaaaaat ttctattatg cagcagtgcc     2700

ttctgctaga aacgttcctt atggaaatat tcagagcaga ttggagctta ggaagaaact     2760

cagctgcaag cctttcaaat ggtaccttga aaatgtctat ccagagttaa gggttccaga     2820

ccatcaggat atagcttttg gggccttgca gcagggaact aactgcctcg acactttggg     2880

acactttgct gatggtgtgg ttggagttta tgaatgtcac aatgctgggg gaaaccagga     2940

atgggccttg acgaaggaga agtcggtgaa gcacatggat ttgtgcctta ctgtggtgga     3000

ccgggcaccg ggctctctta taaagctgca gggctgccga gaaaatgaca gcagacagaa     3060

atgggaacag atcgagggca actccaagct gaggcacgtg ggcagcaacc tgtgcctgga     3120

cagtcgcacg gccaagagcg ggggcctaag cgtggaggtg tgtggcccgg ccctttcgca     3180

gcagtggaag ttcacgctca acctgcagca gtagtctaga aggaggtatt atgaaaattc     3240

ttattagcgg tggtgcaggt tatataggtt ctcatacttt aagacaattt ttaaaaacag     3300

atcatgaaat ttgtgtttta gataatcttt ctaagggttc taaaatcgca atagaagatt     3360

tgcaaaaaac aagagctttt aaatttttcg aacaagattt aagtgatttt caaggcgtaa     3420

aagcattgtt tgagagagaa aaatttgacg ctattgtgca ttttgcagca agcattgaag     3480

tttttgaaag tatgcaaaat cctttaaaat attatatgaa caacactgtt aatacgacaa     3540

atctcatcga aacttgtttg caaactggag tgaataaatt tatattttct tcaacggcgg     3600

ccacttatgg cgaaccacaa actcccgttg tgagcgaaac aagtccttta gcacctatta     3660

atccttatgg gcgtagtaag cttatgagtg aagaagtttt gcgtgatgca agtatggcaa     3720

atcctgaatt taagcattgt attttaagat attttaatgt tgcaggtgct tgtatggatt     3780

atactttagg acaacgctat ccaaaagcga ctttgcttat aaaagttgca gctgaatgtg     3840

ccgcaggaaa acgtgataaa cttttcatat ttggcgatga ttatgataca aaagatggta     3900

cttgcataag agattttatc catgtagatg atatttcaag tgcacattta gcggctttgg     3960

attatttaaa agagaatgaa agcaatgttt ttaatgtagg ttatggacat ggttttagcg     4020

taaaagaagt gattgaagcg atgaaaaaag ttagcggagt ggattttaaa gtagaacttg     4080

ccccacgccg tgcgggtgat cctagtgtat tgatttctga tgcaagtaaa atcagaaatc     4140

ttacttcttg gcagcctaaa tatgatgatt tagagcttat ttgtaaatct gcttttgatt     4200

gggaaaaaca gtgttaataa gcatgcggaa acagtcgaca ggaggtatta tggatgatgc     4260

ggcgattcag cagaccctgg ccaaaatggg cattaaaagc agcgatattc agccggcacc     4320

ggtggcgggt atgaaaaccg tgctgaccaa cagcggcgtg ctgtatatca ccgatgatgg     4380

caaacatatc attcagggcc cgatgtatga tgtgagcggc accgcaccgg tgaacgtgac     4440

caacaaaatg ctgctgaaac agctgaacgc gctggaaaaa gaaatgatcg tgtataaagc     4500

gccgcaggaa aaacacgtta ttaccgtgtt taccgatatt acctgcggct attgccataa     4560

actgcatgag caaatggcgg attataacgc gctgggcatt accgtgcgtt atctggcctt     4620

tccgcgtcag ggcctggata gcgatgccga aaaggaaatg aaagcgatct ggtgcgcgaa     4680

agataaaaac aaagcgttcg atgatgtgat ggcgggcaaa agcgttgcgc cggcgagctg     4740

tgatgtggat attgcggatc attatgcgct gggcgtgcag ctgggtgtta gcggcacccc     4800

ggcggtggtt ctgagcaacg gcaccctggt gccgggttat cagccgccga aagagatgaa     4860

agaatttctg gatgaacacc agaaaatgac cagcggcaaa taatggcaaa tattctgaaa     4920

tgagctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag cggataacaa     4980

tttcacacag gaaacagcca gtccgtttag gtgttttcac gagcaattga ccaacaagga     5040

ccatagattc atatgcgccc atgcacatgc actcgctgta ttgaagagca acgcgtatcc     5100

gcctggtttg atgaacgttt taatcgctcc atgcagcctc tgttaaccgc taaaaacgcc     5160

catttagaag aagataccta taagtggtgg ctccgcctgc aacgtgaaaa acaacccaac     5220

aaccttaacg acaccattcg cgaactgttc caggtagttc ccggtaatgt ggacccactg     5280

ttggaaaaac gtcttgtttc atgtcgtcgt tgcgccgtag ttggcaactc aggtaacctt     5340

aaagaaagct attatggacc acaaattgat tctcatgatt tcgtattacg catgaataaa     5400

gcccccacag aaggtttcga agctgacgtt ggcagtaaaa caacccacca ttttgtatac     5460

cctgaatcct ttcgcgaact tgcccaagaa gtttctatga tccttgtacc gtttaaaact     5520

actgatctcg aatgggtcat ttcagcaact actaccggtc gcatttccca cacctacgtt     5580

cctgtacctg ccaaaattaa agtcaaaaaa gaaaaaattt taatctacca cccagcattt     5640

attaaatacg tgtttgaccg ttggcttcaa ggtcacggcc gttatccatc caccggcatc     5700

ttaagcgtaa ttttttcact ccacatctgc gatgaagtcg atctctacgg tttcggggcc     5760

gattcaaaag gaaactggca tcactattgg gaaaataatc cttcagctgg cgcatttcgt     5820

aaaactggag ttcatgatgg agatttcgaa agcaatgtga ccaccatttt agccagtatt     5880

aataagattc gcatttttaa aggtcgctaa gatccatcga tgcttaggag gtcatatgat     5940

gtttaaaatt tcaatcatct taccaactta taatgtggaa caatatatag caagggcaat     6000

agaaagctgt atcaatcaga cttttaaaga tatagaaata attgtagttg atgattgtgg     6060

aaatgataat agtataaata tagccaaaga atactctaaa aaagacaaaa gaataaaaat     6120

aatccacaat gaaaaaaact taggtctttt aagagcaaga tatgaaggtg tgaaagtagc     6180

aaactctcct tatataatgt ttttagatcc tgatgattat ttggaactaa atgcttgtga     6240

agagtgtata aaaattttag atgaacagga tgaagttgat ttagtgtttt tcaatgctat     6300

tgttgaaagt aatgttattt catataaaaa gtttgacttt aattctggtt tttatagcaa     6360

aaaagagttt gtaaaaaaaa ttattgcaaa gaaaaattta tattggacta tgtgggggaa     6420

acttataaga aagaaattgt atttagaagc ttttgcgagt ttaagactcg agaaagatgt     6480

taaaatcaat atggctgaag atgtattgtt atattatcca atgttaagtc aagctcaaaa     6540

aatagcatat atgaactgta atttatatca ttacgtgcct aataataatt caatttgtaa     6600

tactaagaat gaagtgcttg ttaaaaataa tattcaagag ttgcagttgg ttttaaacta     6660

tttaaggcaa aattatattt taaacaagta ttgtagcgtt ctctatgtgc taattaaata     6720

tttgctatat attcaaatat ataaaataaa accgtgagaa ttccctgatc gatgataagc     6780

tgtcaaacat gagcagatct gagcccgcct aatgagcggg cttttttttc agatctgctt     6840

gaagacgaaa gggcctcgtg atacggagct cgaattcact ggccgtcgtt ttacaacgtc     6900

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     6960

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     7020

tgaatggcga atggcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac     7080

accgcatctg gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc     7140

gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt     7200

acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac     7260

cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga     7320

taataatggt ttcttagacg tcaatatttt atctgattaa taagatgatc ttcttgagat     7380

cgttttggtc tgcgcgtaat ctcttgctct gaaaacgaaa aaaccgcctt gcagggcggt     7440

ttttcgaagg ttctctgagc taccaactct ttgaaccgag gtaactggct tggaggagcg     7500

cagtcaccaa aacttgtcct ttcagtttag ccttaaccgg cgcatgactt caagactaac     7560

tcctctaaat caattaccag tggctgctgc cagtggtgct tttgcatgtc tttccgggtt     7620

ggactcaaga cgatagttac cggataaggc gcagcggtcg gactgaacgg ggggttcgtg     7680

catacagtcc agcttggagc gaactgccta cccggaactg agtgtcaggc gtggaatgag     7740

acaaacgcgg ccataacagc ggaatgacac cggtaaaccg aaaggcagga acaggagagc     7800

gcacgaggga gccgccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     7860

accactgatt tgagcgtcag atttcgtgat gcttgtcagg ggggcggagc ctatggaaaa     7920

acggctttgc cgcggccctc tcacttccct gttaagtatc ttcctggcat cttccaggaa     7980

atctccgccc cgttcgtaag ccatttccgc tcgccgcagt cgaacgaccg agcgtagcga     8040

gtcagtgagc gaggaagcgg aatatatcct gtatcacata ttctgctgac gcaccggtgc     8100

agcctttttt ctcctgccac atgaagcact tcactgacac cctcatcagt gccaacatag     8160

taagccagta tacactccgc tagcgctgat gtccggcggt gcttttgccg ttacgcacca     8220

ccccgtcagt agctgaacag gagggacagc tgatagaaac agaagccact ggagcacctc     8280

aaaaacacca tcatacacta aatcagtaag ttggcagcat cacccgacgc actttgcgcc     8340

gaataaatac ctgtgacgga agatcacttc gcagaataaa taaatcctgg tgtccctgtt     8400

gataccggga agccctgggc caacttttgg cgaaaatgag acgttgatcg gcacgtaaga     8460

ggttccaact ttcaccataa tgaaataaga tcactaccgg gcgtattttt tgagttatcg     8520

agattttcag gagctaagga agctaaaatg gagaaaaaaa tcactggata taccaccgtt     8580

gatatatccc aatggcatcg taaagaacat tttgaggcat ttcagtcagt tgctcaatgt     8640

acctataacc agaccgttca gctggatatt acggcctttt taaagaccgt aaagaaaaat     8700

aagcacaagt tttatccggc ctttattcac attcttgccc gcctgatgaa tgctcatccg     8760

gaattccgta tggcaatgaa agacggtgag ctggtgatat gggatagtgt tcacccttgt     8820

tacaccgttt tccatgagca aactgaaacg ttttcatcgc tctggagtga ataccacgac     8880

gatttccggc agtttctaca catatattcg caagatgtgg cgtgttacgg tgaaaacctg     8940

gcctatttcc ctaaagggtt tattgagaat atgtttttcg tctcagccaa tccctgggtg     9000

agtttcacca gttttgattt aaacgtggcc aatatggaca acttcttcgc ccccgttttc     9060

accatgggca aatattatac gcaaggcgac aaggtgctga tgccgctggc gattcaggtt     9120

catcatgccg tctgtgatgg cttccatgtc ggcagaatgc ttaatgaatt acaacagtac     9180

tgcgatgagt ggcagggcgg ggcgtaattt ttttaaggca gttattggtg cccttaaacg     9240

cctggtgcta cgcctgaata agtgataata agcggatgaa tggcagaaat tcgaaagcaa     9300

attcgacc                                                              9308


<210>  59
<211>  9320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Operon OGO-6

<400>  59
cggtacatgt tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga       60

aaggttttgc gccattcgat ggtgtcctgg cacgacaggt ttcccgactg gaaagcgggc      120

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac      180

tttatgcttc cggctcgtat aatgtgtgga attgtgagcg gataacaatt tcacacagga      240

aacaggatcg atccatcgat gagcttactc cccatccccc tgttgacaat taatcatcgg      300

ctcgtataat gtgtggaatt gtgagcggat aacaatttca cacaggaaac aggatcagct      360

tactccccat ccccctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag      420

cggataacaa tttcacacag gaaacaggat ccatcgatgc ttaggaggtc agatgaaaat      480

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga      540

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa      600

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg      660

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga      720

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa      780

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct      840

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa      900

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc      960

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     1020

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     1080

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     1140

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     1200

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     1260

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     1320

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     1380

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     1440

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     1500

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     1560

agacgcgcag actaattcga gctcgaacaa caacaacaat aacaataaca acaacctcgg     1620

gatcgaggga aggatttcag agttcggttc caaaaagaaa gaccttcatc acagcaatgg     1680

agaagagaaa gcacaaagca tggagaccct ccctccaggg aaagtacggt ggccagactt     1740

taaccaggaa gcttatgttg gagggacgat ggtccgctcc gggcaggacc cttacgcccg     1800

caacaagttc aaccaggtgg agagtgataa gcttcgaatg gacagagcca tccctgacac     1860

ccggcatgac cagtgtcagc ggaagcagtg gcgggtggat ctgccggcca ccagcgtggt     1920

gatcacgttt cacaatgaag ccaggtcggc cctactcagg accgtggtca gcgtgcttaa     1980

gaaaagcccg ccccatctca taaaagaaat catcttggtg gatgactaca gcaatgatcc     2040

tgaggacggg gctctcttgg ggaaaattga gaaagtgcga gttcttagaa atgatcgacg     2100

agaaggcctc atgcgctcac gggttcgggg ggccgatgct gcccaagcca aggtcctgac     2160

cttcctggac agtcactgcg agtgtaatga gcactggctg gagcccctcc tggaaagggt     2220

ggcggaggac aggactcggg ttgtgtcacc catcatcgat gtcattaata tggacaactt     2280

tcagtatgtg ggggcatctg ctgacttgaa gggcggtttt gattggaact tggtattcaa     2340

gtgggattac atgacgcctg agcagagaag gtcccggcag gggaacccag tcgcccctat     2400

aaaaaccccc atgattgctg gtgggctgtt tgtgatggat aagttctatt ttgaagaact     2460

ggggaagtac gacatgatga tggatgtgtg gggaggagag aacctagaga tctcgttccg     2520

cgtgtggcag tgtggtggca gcctggagat catcccgtgc agccgtgtgg gacacgtgtt     2580

ccggaagcag cacccctaca cgttcccggg tggcagtggc actgtctttg cccgaaacac     2640

ccgccgggca gcagaggtct ggatggatga atacaaaaat ttctattatg cagcagtgcc     2700

ttctgctaga aacgttcctt atggaaatat tcagagcaga ttggagctta ggaagaaact     2760

cagctgcaag cctttcaaat ggtaccttga aaatgtctat ccagagttaa gggttccaga     2820

ccatcaggat atagcttttg gggccttgca gcagggaact aactgcctcg acactttggg     2880

acactttgct gatggtgtgg ttggagttta tgaatgtcac aatgctgggg gaaaccagga     2940

atgggccttg acgaaggaga agtcggtgaa gcacatggat ttgtgcctta ctgtggtgga     3000

ccgggcaccg ggctctctta taaagctgca gggctgccga gaaaatgaca gcagacagaa     3060

atgggaacag atcgagggca actccaagct gaggcacgtg ggcagcaacc tgtgcctgga     3120

cagtcgcacg gccaagagcg ggggcctaag cgtggaggtg tgtggcccgg ccctttcgca     3180

gcagtggaag ttcacgctca acctgcagca gtagtctaga aggaggtatt atgaaaattc     3240

ttattagcgg tggtgcaggt tatataggtt ctcatacttt aagacaattt ttaaaaacag     3300

atcatgaaat ttgtgtttta gataatcttt ctaagggttc taaaatcgca atagaagatt     3360

tgcaaaaaac aagagctttt aaatttttcg aacaagattt aagtgatttt caaggcgtaa     3420

aagcattgtt tgagagagaa aaatttgacg ctattgtgca ttttgcagca agcattgaag     3480

tttttgaaag tatgcaaaat cctttaaaat attatatgaa caacactgtt aatacgacaa     3540

atctcatcga aacttgtttg caaactggag tgaataaatt tatattttct tcaacggcgg     3600

ccacttatgg cgaaccacaa actcccgttg tgagcgaaac aagtccttta gcacctatta     3660

atccttatgg gcgtagtaag cttatgagtg aagaagtttt gcgtgatgca agtatggcaa     3720

atcctgaatt taagcattgt attttaagat attttaatgt tgcaggtgct tgtatggatt     3780

atactttagg acaacgctat ccaaaagcga ctttgcttat aaaagttgca gctgaatgtg     3840

ccgcaggaaa acgtgataaa cttttcatat ttggcgatga ttatgataca aaagatggta     3900

cttgcataag agattttatc catgtagatg atatttcaag tgcacattta gcggctttgg     3960

attatttaaa agagaatgaa agcaatgttt ttaatgtagg ttatggacat ggttttagcg     4020

taaaagaagt gattgaagcg atgaaaaaag ttagcggagt ggattttaaa gtagaacttg     4080

ccccacgccg tgcgggtgat cctagtgtat tgatttctga tgcaagtaaa atcagaaatc     4140

ttacttcttg gcagcctaaa tatgatgatt tagagcttat ttgtaaatct gcttttgatt     4200

gggaaaaaca gtgttaataa gcatgcggaa acagtcgaca ggaggtatta tggatgatgc     4260

ggcgattcag cagaccctgg ccaaaatggg cattaaaagc agcgatattc agccggcacc     4320

ggtggcgggt atgaaaaccg tgctgaccaa cagcggcgtg ctgtatatca ccgatgatgg     4380

caaacatatc attcagggcc cgatgtatga tgtgagcggc accgcaccgg tgaacgtgac     4440

caacaaaatg ctgctgaaac agctgaacgc gctggaaaaa gaaatgatcg tgtataaagc     4500

gccgcaggaa aaacacgtta ttaccgtgtt taccgatatt acctgcggct attgccataa     4560

actgcatgag caaatggcgg attataacgc gctgggcatt accgtgcgtt atctggcctt     4620

tccgcgtcag ggcctggata gcgatgccga aaaggaaatg aaagcgatct ggtgcgcgaa     4680

agataaaaac aaagcgttcg atgatgtgat ggcgggcaaa agcgttgcgc cggcgagctg     4740

tgatgtggat attgcggatc attatgcgct gggcgtgcag ctgggtgtta gcggcacccc     4800

ggcggtggtt ctgagcaacg gcaccctggt gccgggttat cagccgccga aagagatgaa     4860

agaatttctg gatgaacacc agaaaatgac cagcggcaaa taatggcaaa tattctgaaa     4920

tgagctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag cggataacaa     4980

tttcacacag gaaacagcca gtccgtttag gtgttttcac gagcaattga ccaacaagga     5040

ccatagatta tgtttaaaat ttcaatcatc ttaccaactt ataatgtgga acaatatata     5100

gcaagggcaa tagaaagctg tatcaatcag acttttaaag atatagaaat aattgtagtt     5160

gatgattgtg gaaatgataa tagtataaat atagccaaag aatactctaa aaaagacaaa     5220

agaataaaaa taatccacaa tgaaaaaaac ttaggtcttt taagagcaag atatgaaggt     5280

gtgaaagtag caaactctcc ttatataatg tttttagatc ctgatgatta tttggaacta     5340

aatgcttgtg aagagtgtat aaaaatttta gatgaacagg atgaagttga tttagtgttt     5400

ttcaatgcta ttgttgaaag taatgttatt tcatataaaa agtttgactt taattctggt     5460

ttttatagca aaaaagagtt tgtaaaaaaa attattgcaa agaaaaattt atattggact     5520

atgtggggga aacttataag aaagaaattg tatttagaag cttttgcgag tttaagactc     5580

gagaaagatg ttaaaatcaa tatggctgaa gatgtattgt tatattatcc aatgttaagt     5640

caagctcaaa aaatagcata tatgaactgt aatttatatc attacgtgcc taataataat     5700

tcaatttgta atactaagaa tgaagtgctt gttaaaaata atattcaaga gttgcagttg     5760

gttttaaact atttaaggca aaattatatt ttaaacaagt attgtagcgt tctctatgtg     5820

ctaattaaat atttgctata tattcaaata tataaaataa aaccgtgaga attctctaga     5880

aataattttg tttaacttta agaaggagat ataccatgcg cccatgcaca tgcactcgct     5940

gtattgaaga gcaacgcgta tccgcctggt ttgatgaacg ttttaatcgc tccatgcagc     6000

ctctgttaac cgctaaaaac gcccatttag aagaagatac ctataagtgg tggctccgcc     6060

tgcaacgtga aaaacaaccc aacaacctta acgacaccat tcgcgaactg ttccaggtag     6120

ttcccggtaa tgtggaccca ctgttggaaa aacgtcttgt ttcatgtcgt cgttgcgccg     6180

tagttggcaa ctcaggtaac cttaaagaaa gctattatgg accacaaatt gattctcatg     6240

atttcgtatt acgcatgaat aaagccccca cagaaggttt cgaagctgac gttggcagta     6300

aaacaaccca ccattttgta taccctgaat cctttcgcga acttgcccaa gaagtttcta     6360

tgatccttgt accgtttaaa actactgatc tcgaatgggt catttcagca actactaccg     6420

gtcgcatttc ccacacctac gttcctgtac ctgccaaaat taaagtcaaa aaagaaaaaa     6480

ttttaatcta ccacccagca tttattaaat acgtgtttga ccgttggctt caaggtcacg     6540

gccgttatcc atccaccggc atcttaagcg taattttttc actccacatc tgcgatgaag     6600

tcgatctcta cggtttcggg gccgattcaa aaggaaactg gcatcactat tgggaaaata     6660

atccttcagc tggcgcattt cgtaaaactg gagttcatga tggagatttc gaaagcaatg     6720

tgaccaccat tttagccagt attaataaga ttcgcatttt taaaggtcgc taagatccat     6780

cgattgataa gctgtcaaac atgagcagat ctgagcccgc ctaatgagcg ggcttttttt     6840

tcagatctgc ttgaagacga aagggcctcg tgatacggag ctcgaattca ctggccgtcg     6900

ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac     6960

atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac     7020

agttgcgcag cctgaatggc gaatggcgcc tgatgcggta ttttctcctt acgcatctgt     7080

gcggtatttc acaccgcatc tggtgcactc tcagtacaat ctgctctgat gccgcatagt     7140

taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc     7200

cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt     7260

caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg     7320

ttaatgtcat gataataatg gtttcttaga cgtcaatatt ttatctgatt aataagatga     7380

tcttcttgag atcgttttgg tctgcgcgta atctcttgct ctgaaaacga aaaaaccgcc     7440

ttgcagggcg gtttttcgaa ggttctctga gctaccaact ctttgaaccg aggtaactgg     7500

cttggaggag cgcagtcacc aaaacttgtc ctttcagttt agccttaacc ggcgcatgac     7560

ttcaagacta actcctctaa atcaattacc agtggctgct gccagtggtg cttttgcatg     7620

tctttccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cggactgaac     7680

ggggggttcg tgcatacagt ccagcttgga gcgaactgcc tacccggaac tgagtgtcag     7740

gcgtggaatg agacaaacgc ggccataaca gcggaatgac accggtaaac cgaaaggcag     7800

gaacaggaga gcgcacgagg gagccgccag ggggaaacgc ctggtatctt tatagtcctg     7860

tcgggtttcg ccaccactga tttgagcgtc agatttcgtg atgcttgtca ggggggcgga     7920

gcctatggaa aaacggcttt gccgcggccc tctcacttcc ctgttaagta tcttcctggc     7980

atcttccagg aaatctccgc cccgttcgta agccatttcc gctcgccgca gtcgaacgac     8040

cgagcgtagc gagtcagtga gcgaggaagc ggaatatatc ctgtatcaca tattctgctg     8100

acgcaccggt gcagcctttt ttctcctgcc acatgaagca cttcactgac accctcatca     8160

gtgccaacat agtaagccag tatacactcc gctagcgctg atgtccggcg gtgcttttgc     8220

cgttacgcac caccccgtca gtagctgaac aggagggaca gctgatagaa acagaagcca     8280

ctggagcacc tcaaaaacac catcatacac taaatcagta agttggcagc atcacccgac     8340

gcactttgcg ccgaataaat acctgtgacg gaagatcact tcgcagaata aataaatcct     8400

ggtgtccctg ttgataccgg gaagccctgg gccaactttt ggcgaaaatg agacgttgat     8460

cggcacgtaa gaggttccaa ctttcaccat aatgaaataa gatcactacc gggcgtattt     8520

tttgagttat cgagattttc aggagctaag gaagctaaaa tggagaaaaa aatcactgga     8580

tataccaccg ttgatatatc ccaatggcat cgtaaagaac attttgaggc atttcagtca     8640

gttgctcaat gtacctataa ccagaccgtt cagctggata ttacggcctt tttaaagacc     8700

gtaaagaaaa ataagcacaa gttttatccg gcctttattc acattcttgc ccgcctgatg     8760

aatgctcatc cggaattccg tatggcaatg aaagacggtg agctggtgat atgggatagt     8820

gttcaccctt gttacaccgt tttccatgag caaactgaaa cgttttcatc gctctggagt     8880

gaataccacg acgatttccg gcagtttcta cacatatatt cgcaagatgt ggcgtgttac     8940

ggtgaaaacc tggcctattt ccctaaaggg tttattgaga atatgttttt cgtctcagcc     9000

aatccctggg tgagtttcac cagttttgat ttaaacgtgg ccaatatgga caacttcttc     9060

gcccccgttt tcaccatggg caaatattat acgcaaggcg acaaggtgct gatgccgctg     9120

gcgattcagg ttcatcatgc cgtctgtgat ggcttccatg tcggcagaat gcttaatgaa     9180

ttacaacagt actgcgatga gtggcagggc ggggcgtaat ttttttaagg cagttattgg     9240

tgcccttaaa cgcctggtgc tacgcctgaa taagtgataa taagcggatg aatggcagaa     9300

attcgaaagc aaattcgacc                                                 9320


<210>  60
<211>  10147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Operon OGO-7

<400>  60
cggtacatgt tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga       60

aaggttttgc gccattcgat ggtgtcctgg cacgacaggt ttcccgactg gaaagcgggc      120

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac      180

tttatgcttc cggctcgtat aatgtgtgga attgtgagcg gataacaatt tcacacagga      240

aacaggatcg atccatcgat gagcttactc cccatccccc tgttgacaat taatcatcgg      300

ctcgtataat gtgtggaatt gtgagcggat aacaatttca cacaggaaac aggatcagct      360

tactccccat ccccctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag      420

cggataacaa tttcacacag gaaacaggat ccatcgatgc ttaggaggtc agatgaaaat      480

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga      540

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa      600

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg      660

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga      720

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa      780

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct      840

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa      900

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc      960

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     1020

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     1080

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     1140

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     1200

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     1260

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     1320

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     1380

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     1440

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     1500

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     1560

agacgcgcag actaattcga gctcgaacaa caacaacaat aacaataaca acaacctcgg     1620

gatcgaggga aggatttcag agttcggttc caaaaagaaa gaccttcatc acagcaatgg     1680

agaagagaaa gcacaaagca tggagaccct ccctccaggg aaagtacggt ggccagactt     1740

taaccaggaa gcttatgttg gagggacgat ggtccgctcc gggcaggacc cttacgcccg     1800

caacaagttc aaccaggtgg agagtgataa gcttcgaatg gacagagcca tccctgacac     1860

ccggcatgac cagtgtcagc ggaagcagtg gcgggtggat ctgccggcca ccagcgtggt     1920

gatcacgttt cacaatgaag ccaggtcggc cctactcagg accgtggtca gcgtgcttaa     1980

gaaaagcccg ccccatctca taaaagaaat catcttggtg gatgactaca gcaatgatcc     2040

tgaggacggg gctctcttgg ggaaaattga gaaagtgcga gttcttagaa atgatcgacg     2100

agaaggcctc atgcgctcac gggttcgggg ggccgatgct gcccaagcca aggtcctgac     2160

cttcctggac agtcactgcg agtgtaatga gcactggctg gagcccctcc tggaaagggt     2220

ggcggaggac aggactcggg ttgtgtcacc catcatcgat gtcattaata tggacaactt     2280

tcagtatgtg ggggcatctg ctgacttgaa gggcggtttt gattggaact tggtattcaa     2340

gtgggattac atgacgcctg agcagagaag gtcccggcag gggaacccag tcgcccctat     2400

aaaaaccccc atgattgctg gtgggctgtt tgtgatggat aagttctatt ttgaagaact     2460

ggggaagtac gacatgatga tggatgtgtg gggaggagag aacctagaga tctcgttccg     2520

cgtgtggcag tgtggtggca gcctggagat catcccgtgc agccgtgtgg gacacgtgtt     2580

ccggaagcag cacccctaca cgttcccggg tggcagtggc actgtctttg cccgaaacac     2640

ccgccgggca gcagaggtct ggatggatga atacaaaaat ttctattatg cagcagtgcc     2700

ttctgctaga aacgttcctt atggaaatat tcagagcaga ttggagctta ggaagaaact     2760

cagctgcaag cctttcaaat ggtaccttga aaatgtctat ccagagttaa gggttccaga     2820

ccatcaggat atagcttttg gggccttgca gcagggaact aactgcctcg acactttggg     2880

acactttgct gatggtgtgg ttggagttta tgaatgtcac aatgctgggg gaaaccagga     2940

atgggccttg acgaaggaga agtcggtgaa gcacatggat ttgtgcctta ctgtggtgga     3000

ccgggcaccg ggctctctta taaagctgca gggctgccga gaaaatgaca gcagacagaa     3060

atgggaacag atcgagggca actccaagct gaggcacgtg ggcagcaacc tgtgcctgga     3120

cagtcgcacg gccaagagcg ggggcctaag cgtggaggtg tgtggcccgg ccctttcgca     3180

gcagtggaag ttcacgctca acctgcagca gtagtctaga aggaggtatt atgaaaattc     3240

ttattagcgg tggtgcaggt tatataggtt ctcatacttt aagacaattt ttaaaaacag     3300

atcatgaaat ttgtgtttta gataatcttt ctaagggttc taaaatcgca atagaagatt     3360

tgcaaaaaac aagagctttt aaatttttcg aacaagattt aagtgatttt caaggcgtaa     3420

aagcattgtt tgagagagaa aaatttgacg ctattgtgca ttttgcagca agcattgaag     3480

tttttgaaag tatgcaaaat cctttaaaat attatatgaa caacactgtt aatacgacaa     3540

atctcatcga aacttgtttg caaactggag tgaataaatt tatattttct tcaacggcgg     3600

ccacttatgg cgaaccacaa actcccgttg tgagcgaaac aagtccttta gcacctatta     3660

atccttatgg gcgtagtaag cttatgagtg aagaagtttt gcgtgatgca agtatggcaa     3720

atcctgaatt taagcattgt attttaagat attttaatgt tgcaggtgct tgtatggatt     3780

atactttagg acaacgctat ccaaaagcga ctttgcttat aaaagttgca gctgaatgtg     3840

ccgcaggaaa acgtgataaa cttttcatat ttggcgatga ttatgataca aaagatggta     3900

cttgcataag agattttatc catgtagatg atatttcaag tgcacattta gcggctttgg     3960

attatttaaa agagaatgaa agcaatgttt ttaatgtagg ttatggacat ggttttagcg     4020

taaaagaagt gattgaagcg atgaaaaaag ttagcggagt ggattttaaa gtagaacttg     4080

ccccacgccg tgcgggtgat cctagtgtat tgatttctga tgcaagtaaa atcagaaatc     4140

ttacttcttg gcagcctaaa tatgatgatt tagagcttat ttgtaaatct gcttttgatt     4200

gggaaaaaca gtgttaataa gcatgcggaa acagtcgaca ggaggtatta tggatgatgc     4260

ggcgattcag cagaccctgg ccaaaatggg cattaaaagc agcgatattc agccggcacc     4320

ggtggcgggt atgaaaaccg tgctgaccaa cagcggcgtg ctgtatatca ccgatgatgg     4380

caaacatatc attcagggcc cgatgtatga tgtgagcggc accgcaccgg tgaacgtgac     4440

caacaaaatg ctgctgaaac agctgaacgc gctggaaaaa gaaatgatcg tgtataaagc     4500

gccgcaggaa aaacacgtta ttaccgtgtt taccgatatt acctgcggct attgccataa     4560

actgcatgag caaatggcgg attataacgc gctgggcatt accgtgcgtt atctggcctt     4620

tccgcgtcag ggcctggata gcgatgccga aaaggaaatg aaagcgatct ggtgcgcgaa     4680

agataaaaac aaagcgttcg atgatgtgat ggcgggcaaa agcgttgcgc cggcgagctg     4740

tgatgtggat attgcggatc attatgcgct gggcgtgcag ctgggtgtta gcggcacccc     4800

ggcggtggtt ctgagcaacg gcaccctggt gccgggttat cagccgccga aagagatgaa     4860

agaatttctg gatgaacacc agaaaatgac cagcggcaaa taatggcaaa tattctgaaa     4920

tgagctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag cggataacaa     4980

tttcacacag gaaacagcca gtccgtttag gtgttttcac gagcaattga ccaacaagga     5040

ccatagattc atatgcgccc atgcacatgc actcgctgta ttgaagagca acgcgtatcc     5100

gcctggtttg atgaacgttt taatcgctcc atgcagcctc tgttaaccgc taaaaacgcc     5160

catttagaag aagataccta taagtggtgg ctccgcctgc aacgtgaaaa acaacccaac     5220

aaccttaacg acaccattcg cgaactgttc caggtagttc ccggtaatgt ggacccactg     5280

ttggaaaaac gtcttgtttc atgtcgtcgt tgcgccgtag ttggcaactc aggtaacctt     5340

aaagaaagct attatggacc acaaattgat tctcatgatt tcgtattacg catgaataaa     5400

gcccccacag aaggtttcga agctgacgtt ggcagtaaaa caacccacca ttttgtatac     5460

cctgaatcct ttcgcgaact tgcccaagaa gtttctatga tccttgtacc gtttaaaact     5520

actgatctcg aatgggtcat ttcagcaact actaccggtc gcatttccca cacctacgtt     5580

cctgtacctg ccaaaattaa agtcaaaaaa gaaaaaattt taatctacca cccagcattt     5640

attaaatacg tgtttgaccg ttggcttcaa ggtcacggcc gttatccatc caccggcatc     5700

ttaagcgtaa ttttttcact ccacatctgc gatgaagtcg atctctacgg tttcggggcc     5760

gattcaaaag gaaactggca tcactattgg gaaaataatc cttcagctgg cgcatttcgt     5820

aaaactggag ttcatgatgg agatttcgaa agcaatgtga ccaccatttt agccagtatt     5880

aataagattc gcatttttaa aggtcgctaa gatccatcga tgcttaggag gtcatatgat     5940

gtttaaaatt tcaatcatct taccaactta taatgtggaa caatatatag caagggcaat     6000

agaaagctgt atcaatcaga cttttaaaga tatagaaata attgtagttg atgattgtgg     6060

aaatgataat agtataaata tagccaaaga atactctaaa aaagacaaaa gaataaaaat     6120

aatccacaat gaaaaaaact taggtctttt aagagcaaga tatgaaggtg tgaaagtagc     6180

aaactctcct tatataatgt ttttagatcc tgatgattat ttggaactaa atgcttgtga     6240

agagtgtata aaaattttag atgaacagga tgaagttgat ttagtgtttt tcaatgctat     6300

tgttgaaagt aatgttattt catataaaaa gtttgacttt aattctggtt tttatagcaa     6360

aaaagagttt gtaaaaaaaa ttattgcaaa gaaaaattta tattggacta tgtgggggaa     6420

acttataaga aagaaattgt atttagaagc ttttgcgagt ttaagactcg agaaagatgt     6480

taaaatcaat atggctgaag atgtattgtt atattatcca atgttaagtc aagctcaaaa     6540

aatagcatat atgaactgta atttatatca ttacgtgcct aataataatt caatttgtaa     6600

tactaagaat gaagtgcttg ttaaaaataa tattcaagag ttgcagttgg ttttaaacta     6660

tttaaggcaa aattatattt taaacaagta ttgtagcgtt ctctatgtgc taattaaata     6720

tttgctatat attcaaatat ataaaataaa accgtgagaa ttccctggta taagaaggag     6780

atatacatat gacctgcctg gatcaccact tcccgaccgg ttctcgtccg accgttccgg     6840

gtccgctgca cttcagcggt tatagtagcg ttccggatgg taaaccgctg gttcgtgaac     6900

cgtgtcgtag ctgcgctgtg gtttcttctt ctggccagat gctgggtagt ggtctgggtg     6960

cggaaattga ttctgctgaa tgtgttttcc gtatgaacca agccccgact gttggttttg     7020

aagctgatgt tggtcagcgt tctaccctgc gtgttgtttc ccacacctct gttccgctgc     7080

tgctgcgtaa ctatagccat tatttccaaa aagcgcgtga taccctgtat atggtttggg     7140

gtcagggtcg tcacatggat cgtgttctgg gtggtcgtac ctatcgtacc ctgctgcagc     7200

tgacccgtat gtatccgggt ctgcaggttt acaccttcac cgaacgtatg atggcatact     7260

gtgatcagat ctttcaggat gaaactggca aaaaccgtcg tcagagcggt tctttcctgt     7320

ctactggttg gtttacgatg atcctggctc tggaactgtg tgaagaaatc gttgtttatg     7380

gtatggtttc cgatagctat tgccgtgaaa aaagccaccc gtctgttccg tatcattact     7440

ttgaaaaagg tcgtctggat gaatgccaga tgtacctggc acatgaacag gctccgcgtt     7500

ctgctcatcg ttttatcact gaaaaagcag ttttctctcg ttgggctaaa aaacgtccga     7560

ttgtttttgc acacccgtct tggcgtaccg aataagtcga gtctggatcg atgataagct     7620

gtcaaacatg agcagatctg agcccgccta atgagcgggc ttttttttca gatctgcttg     7680

aagacgaaag ggcctcgtga tacggagctc gaattcactg gccgtcgttt tacaacgtcg     7740

tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc     7800

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct     7860

gaatggcgaa tggcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     7920

ccgcatctgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg     7980

acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta     8040

cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc     8100

gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     8160

aataatggtt tcttagacgt caatatttta tctgattaat aagatgatct tcttgagatc     8220

gttttggtct gcgcgtaatc tcttgctctg aaaacgaaaa aaccgccttg cagggcggtt     8280

tttcgaaggt tctctgagct accaactctt tgaaccgagg taactggctt ggaggagcgc     8340

agtcaccaaa acttgtcctt tcagtttagc cttaaccggc gcatgacttc aagactaact     8400

cctctaaatc aattaccagt ggctgctgcc agtggtgctt ttgcatgtct ttccgggttg     8460

gactcaagac gatagttacc ggataaggcg cagcggtcgg actgaacggg gggttcgtgc     8520

atacagtcca gcttggagcg aactgcctac ccggaactga gtgtcaggcg tggaatgaga     8580

caaacgcggc cataacagcg gaatgacacc ggtaaaccga aaggcaggaa caggagagcg     8640

cacgagggag ccgccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     8700

ccactgattt gagcgtcaga tttcgtgatg cttgtcaggg gggcggagcc tatggaaaaa     8760

cggctttgcc gcggccctct cacttccctg ttaagtatct tcctggcatc ttccaggaaa     8820

tctccgcccc gttcgtaagc catttccgct cgccgcagtc gaacgaccga gcgtagcgag     8880

tcagtgagcg aggaagcgga atatatcctg tatcacatat tctgctgacg caccggtgca     8940

gccttttttc tcctgccaca tgaagcactt cactgacacc ctcatcagtg ccaacatagt     9000

aagccagtat acactccgct agcgctgatg tccggcggtg cttttgccgt tacgcaccac     9060

cccgtcagta gctgaacagg agggacagct gatagaaaca gaagccactg gagcacctca     9120

aaaacaccat catacactaa atcagtaagt tggcagcatc acccgacgca ctttgcgccg     9180

aataaatacc tgtgacggaa gatcacttcg cagaataaat aaatcctggt gtccctgttg     9240

ataccgggaa gccctgggcc aacttttggc gaaaatgaga cgttgatcgg cacgtaagag     9300

gttccaactt tcaccataat gaaataagat cactaccggg cgtatttttt gagttatcga     9360

gattttcagg agctaaggaa gctaaaatgg agaaaaaaat cactggatat accaccgttg     9420

atatatccca atggcatcgt aaagaacatt ttgaggcatt tcagtcagtt gctcaatgta     9480

cctataacca gaccgttcag ctggatatta cggccttttt aaagaccgta aagaaaaata     9540

agcacaagtt ttatccggcc tttattcaca ttcttgcccg cctgatgaat gctcatccgg     9600

aattccgtat ggcaatgaaa gacggtgagc tggtgatatg ggatagtgtt cacccttgtt     9660

acaccgtttt ccatgagcaa actgaaacgt tttcatcgct ctggagtgaa taccacgacg     9720

atttccggca gtttctacac atatattcgc aagatgtggc gtgttacggt gaaaacctgg     9780

cctatttccc taaagggttt attgagaata tgtttttcgt ctcagccaat ccctgggtga     9840

gtttcaccag ttttgattta aacgtggcca atatggacaa cttcttcgcc cccgttttca     9900

ccatgggcaa atattatacg caaggcgaca aggtgctgat gccgctggcg attcaggttc     9960

atcatgccgt ctgtgatggc ttccatgtcg gcagaatgct taatgaatta caacagtact    10020

gcgatgagtg gcagggcggg gcgtaatttt tttaaggcag ttattggtgc ccttaaacgc    10080

ctggtgctac gcctgaataa gtgataataa gcggatgaat ggcagaaatt cgaaagcaaa    10140

ttcgacc                                                              10147


<210>  61
<211>  10158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Operon OGO-8

<400>  61
cggtacatgt tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga       60

aaggttttgc gccattcgat ggtgtcctgg cacgacaggt ttcccgactg gaaagcgggc      120

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac      180

tttatgcttc cggctcgtat aatgtgtgga attgtgagcg gataacaatt tcacacagga      240

aacaggatcg atccatcgat gagcttactc cccatccccc tgttgacaat taatcatcgg      300

ctcgtataat gtgtggaatt gtgagcggat aacaatttca cacaggaaac aggatcagct      360

tactccccat ccccctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag      420

cggataacaa tttcacacag gaaacaggat ccatcgatgc ttaggaggtc agatgaaaat      480

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga      540

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa      600

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg      660

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga      720

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa      780

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct      840

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa      900

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc      960

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     1020

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     1080

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     1140

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     1200

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     1260

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     1320

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     1380

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     1440

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     1500

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     1560

agacgcgcag actaattcga gctcgaacaa caacaacaat aacaataaca acaacctcgg     1620

gatcgaggga aggatttcag agttcggttc caaaaagaaa gaccttcatc acagcaatgg     1680

agaagagaaa gcacaaagca tggagaccct ccctccaggg aaagtacggt ggccagactt     1740

taaccaggaa gcttatgttg gagggacgat ggtccgctcc gggcaggacc cttacgcccg     1800

caacaagttc aaccaggtgg agagtgataa gcttcgaatg gacagagcca tccctgacac     1860

ccggcatgac cagtgtcagc ggaagcagtg gcgggtggat ctgccggcca ccagcgtggt     1920

gatcacgttt cacaatgaag ccaggtcggc cctactcagg accgtggtca gcgtgcttaa     1980

gaaaagcccg ccccatctca taaaagaaat catcttggtg gatgactaca gcaatgatcc     2040

tgaggacggg gctctcttgg ggaaaattga gaaagtgcga gttcttagaa atgatcgacg     2100

agaaggcctc atgcgctcac gggttcgggg ggccgatgct gcccaagcca aggtcctgac     2160

cttcctggac agtcactgcg agtgtaatga gcactggctg gagcccctcc tggaaagggt     2220

ggcggaggac aggactcggg ttgtgtcacc catcatcgat gtcattaata tggacaactt     2280

tcagtatgtg ggggcatctg ctgacttgaa gggcggtttt gattggaact tggtattcaa     2340

gtgggattac atgacgcctg agcagagaag gtcccggcag gggaacccag tcgcccctat     2400

aaaaaccccc atgattgctg gtgggctgtt tgtgatggat aagttctatt ttgaagaact     2460

ggggaagtac gacatgatga tggatgtgtg gggaggagag aacctagaga tctcgttccg     2520

cgtgtggcag tgtggtggca gcctggagat catcccgtgc agccgtgtgg gacacgtgtt     2580

ccggaagcag cacccctaca cgttcccggg tggcagtggc actgtctttg cccgaaacac     2640

ccgccgggca gcagaggtct ggatggatga atacaaaaat ttctattatg cagcagtgcc     2700

ttctgctaga aacgttcctt atggaaatat tcagagcaga ttggagctta ggaagaaact     2760

cagctgcaag cctttcaaat ggtaccttga aaatgtctat ccagagttaa gggttccaga     2820

ccatcaggat atagcttttg gggccttgca gcagggaact aactgcctcg acactttggg     2880

acactttgct gatggtgtgg ttggagttta tgaatgtcac aatgctgggg gaaaccagga     2940

atgggccttg acgaaggaga agtcggtgaa gcacatggat ttgtgcctta ctgtggtgga     3000

ccgggcaccg ggctctctta taaagctgca gggctgccga gaaaatgaca gcagacagaa     3060

atgggaacag atcgagggca actccaagct gaggcacgtg ggcagcaacc tgtgcctgga     3120

cagtcgcacg gccaagagcg ggggcctaag cgtggaggtg tgtggcccgg ccctttcgca     3180

gcagtggaag ttcacgctca acctgcagca gtagtctagg tataagaagg agatatacat     3240

atgacctgcc tggatcacca cttcccgacc ggttctcgtc cgaccgttcc gggtccgctg     3300

cacttcagcg gttatagtag cgttccggat ggtaaaccgc tggttcgtga accgtgtcgt     3360

agctgcgctg tggtttcttc ttctggccag atgctgggta gtggtctggg tgcggaaatt     3420

gattctgctg aatgtgtttt ccgtatgaac caagccccga ctgttggttt tgaagctgat     3480

gttggtcagc gttctaccct gcgtgttgtt tcccacacct ctgttccgct gctgctgcgt     3540

aactatagcc attatttcca aaaagcgcgt gataccctgt atatggtttg gggtcagggt     3600

cgtcacatgg atcgtgttct gggtggtcgt acctatcgta ccctgctgca gctgacccgt     3660

atgtatccgg gtctgcaggt ttacaccttc accgaacgta tgatggcata ctgtgatcag     3720

atctttcagg atgaaactgg caaaaaccgt cgtcagagcg gttctttcct gtctactggt     3780

tggtttacga tgatcctggc tctggaactg tgtgaagaaa tcgttgttta tggtatggtt     3840

tccgatagct attgccgtga aaaaagccac ccgtctgttc cgtatcatta ctttgaaaaa     3900

ggtcgtctgg atgaatgcca gatgtacctg gcacatgaac aggctccgcg ttctgctcat     3960

cgttttatca ctgaaaaagc agttttctct cgttgggcta aaaaacgtcc gattgttttt     4020

gcacacccgt cttggcgtac cgaataagtc gagtctggta aagaaaccga aggaggtatt     4080

atgaaaattc ttattagcgg tggtgcaggt tatataggtt ctcatacttt aagacaattt     4140

ttaaaaacag atcatgaaat ttgtgtttta gataatcttt ctaagggttc taaaatcgca     4200

atagaagatt tgcaaaaaac aagagctttt aaatttttcg aacaagattt aagtgatttt     4260

caaggcgtaa aagcattgtt tgagagagaa aaatttgacg ctattgtgca ttttgcagca     4320

agcattgaag tttttgaaag tatgcaaaat cctttaaaat attatatgaa caacactgtt     4380

aatacgacaa atctcatcga aacttgtttg caaactggag tgaataaatt tatattttct     4440

tcaacggcgg ccacttatgg cgaaccacaa actcccgttg tgagcgaaac aagtccttta     4500

gcacctatta atccttatgg gcgtagtaag cttatgagtg aagaagtttt gcgtgatgca     4560

agtatggcaa atcctgaatt taagcattgt attttaagat attttaatgt tgcaggtgct     4620

tgtatggatt atactttagg acaacgctat ccaaaagcga ctttgcttat aaaagttgca     4680

gctgaatgtg ccgcaggaaa acgtgataaa cttttcatat ttggcgatga ttatgataca     4740

aaagatggta cttgcataag agattttatc catgtagatg atatttcaag tgcacattta     4800

gcggctttgg attatttaaa agagaatgaa agcaatgttt ttaatgtagg ttatggacat     4860

ggttttagcg taaaagaagt gattgaagcg atgaaaaaag ttagcggagt ggattttaaa     4920

gtagaacttg ccccacgccg tgcgggtgat cctagtgtat tgatttctga tgcaagtaaa     4980

atcagaaatc ttacttcttg gcagcctaaa tatgatgatt tagagcttat ttgtaaatct     5040

gcttttgatt gggaaaaaca gtgttaataa gcatgcggaa acagtcgaca ggaggtatta     5100

tggatgatgc ggcgattcag cagaccctgg ccaaaatggg cattaaaagc agcgatattc     5160

agccggcacc ggtggcgggt atgaaaaccg tgctgaccaa cagcggcgtg ctgtatatca     5220

ccgatgatgg caaacatatc attcagggcc cgatgtatga tgtgagcggc accgcaccgg     5280

tgaacgtgac caacaaaatg ctgctgaaac agctgaacgc gctggaaaaa gaaatgatcg     5340

tgtataaagc gccgcaggaa aaacacgtta ttaccgtgtt taccgatatt acctgcggct     5400

attgccataa actgcatgag caaatggcgg attataacgc gctgggcatt accgtgcgtt     5460

atctggcctt tccgcgtcag ggcctggata gcgatgccga aaaggaaatg aaagcgatct     5520

ggtgcgcgaa agataaaaac aaagcgttcg atgatgtgat ggcgggcaaa agcgttgcgc     5580

cggcgagctg tgatgtggat attgcggatc attatgcgct gggcgtgcag ctgggtgtta     5640

gcggcacccc ggcggtggtt ctgagcaacg gcaccctggt gccgggttat cagccgccga     5700

aagagatgaa agaatttctg gatgaacacc agaaaatgac cagcggcaaa taatggcaaa     5760

tattctgaaa tgagctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag     5820

cggataacaa tttcacacag gaaacagcca gtccgtttag gtgttttcac gagcaattga     5880

ccaacaagga ccatagattc atatgcgccc atgcacatgc actcgctgta ttgaagagca     5940

acgcgtatcc gcctggtttg atgaacgttt taatcgctcc atgcagcctc tgttaaccgc     6000

taaaaacgcc catttagaag aagataccta taagtggtgg ctccgcctgc aacgtgaaaa     6060

acaacccaac aaccttaacg acaccattcg cgaactgttc caggtagttc ccggtaatgt     6120

ggacccactg ttggaaaaac gtcttgtttc atgtcgtcgt tgcgccgtag ttggcaactc     6180

aggtaacctt aaagaaagct attatggacc acaaattgat tctcatgatt tcgtattacg     6240

catgaataaa gcccccacag aaggtttcga agctgacgtt ggcagtaaaa caacccacca     6300

ttttgtatac cctgaatcct ttcgcgaact tgcccaagaa gtttctatga tccttgtacc     6360

gtttaaaact actgatctcg aatgggtcat ttcagcaact actaccggtc gcatttccca     6420

cacctacgtt cctgtacctg ccaaaattaa agtcaaaaaa gaaaaaattt taatctacca     6480

cccagcattt attaaatacg tgtttgaccg ttggcttcaa ggtcacggcc gttatccatc     6540

caccggcatc ttaagcgtaa ttttttcact ccacatctgc gatgaagtcg atctctacgg     6600

tttcggggcc gattcaaaag gaaactggca tcactattgg gaaaataatc cttcagctgg     6660

cgcatttcgt aaaactggag ttcatgatgg agatttcgaa agcaatgtga ccaccatttt     6720

agccagtatt aataagattc gcatttttaa aggtcgctaa gatccatcga tgcttaggag     6780

gtcatatgat gtttaaaatt tcaatcatct taccaactta taatgtggaa caatatatag     6840

caagggcaat agaaagctgt atcaatcaga cttttaaaga tatagaaata attgtagttg     6900

atgattgtgg aaatgataat agtataaata tagccaaaga atactctaaa aaagacaaaa     6960

gaataaaaat aatccacaat gaaaaaaact taggtctttt aagagcaaga tatgaaggtg     7020

tgaaagtagc aaactctcct tatataatgt ttttagatcc tgatgattat ttggaactaa     7080

atgcttgtga agagtgtata aaaattttag atgaacagga tgaagttgat ttagtgtttt     7140

tcaatgctat tgttgaaagt aatgttattt catataaaaa gtttgacttt aattctggtt     7200

tttatagcaa aaaagagttt gtaaaaaaaa ttattgcaaa gaaaaattta tattggacta     7260

tgtgggggaa acttataaga aagaaattgt atttagaagc ttttgcgagt ttaagactcg     7320

agaaagatgt taaaatcaat atggctgaag atgtattgtt atattatcca atgttaagtc     7380

aagctcaaaa aatagcatat atgaactgta atttatatca ttacgtgcct aataataatt     7440

caatttgtaa tactaagaat gaagtgcttg ttaaaaataa tattcaagag ttgcagttgg     7500

ttttaaacta tttaaggcaa aattatattt taaacaagta ttgtagcgtt ctctatgtgc     7560

taattaaata tttgctatat attcaaatat ataaaataaa accgtgagaa ttccctgatc     7620

gatgataagc tgtcaaacat gagcagatct gagcccgcct aatgagcggg cttttttttc     7680

agatctgctt gaagacgaaa gggcctcgtg atacggagct cgaattcact ggccgtcgtt     7740

ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat     7800

ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag     7860

ttgcgcagcc tgaatggcga atggcgcctg atgcggtatt ttctccttac gcatctgtgc     7920

ggtatttcac accgcatctg gtgcactctc agtacaatct gctctgatgc cgcatagtta     7980

agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg     8040

gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca     8100

ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt tttataggtt     8160

aatgtcatga taataatggt ttcttagacg tcaatatttt atctgattaa taagatgatc     8220

ttcttgagat cgttttggtc tgcgcgtaat ctcttgctct gaaaacgaaa aaaccgcctt     8280

gcagggcggt ttttcgaagg ttctctgagc taccaactct ttgaaccgag gtaactggct     8340

tggaggagcg cagtcaccaa aacttgtcct ttcagtttag ccttaaccgg cgcatgactt     8400

caagactaac tcctctaaat caattaccag tggctgctgc cagtggtgct tttgcatgtc     8460

tttccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg gactgaacgg     8520

ggggttcgtg catacagtcc agcttggagc gaactgccta cccggaactg agtgtcaggc     8580

gtggaatgag acaaacgcgg ccataacagc ggaatgacac cggtaaaccg aaaggcagga     8640

acaggagagc gcacgaggga gccgccaggg ggaaacgcct ggtatcttta tagtcctgtc     8700

gggtttcgcc accactgatt tgagcgtcag atttcgtgat gcttgtcagg ggggcggagc     8760

ctatggaaaa acggctttgc cgcggccctc tcacttccct gttaagtatc ttcctggcat     8820

cttccaggaa atctccgccc cgttcgtaag ccatttccgc tcgccgcagt cgaacgaccg     8880

agcgtagcga gtcagtgagc gaggaagcgg aatatatcct gtatcacata ttctgctgac     8940

gcaccggtgc agcctttttt ctcctgccac atgaagcact tcactgacac cctcatcagt     9000

gccaacatag taagccagta tacactccgc tagcgctgat gtccggcggt gcttttgccg     9060

ttacgcacca ccccgtcagt agctgaacag gagggacagc tgatagaaac agaagccact     9120

ggagcacctc aaaaacacca tcatacacta aatcagtaag ttggcagcat cacccgacgc     9180

actttgcgcc gaataaatac ctgtgacgga agatcacttc gcagaataaa taaatcctgg     9240

tgtccctgtt gataccggga agccctgggc caacttttgg cgaaaatgag acgttgatcg     9300

gcacgtaaga ggttccaact ttcaccataa tgaaataaga tcactaccgg gcgtattttt     9360

tgagttatcg agattttcag gagctaagga agctaaaatg gagaaaaaaa tcactggata     9420

taccaccgtt gatatatccc aatggcatcg taaagaacat tttgaggcat ttcagtcagt     9480

tgctcaatgt acctataacc agaccgttca gctggatatt acggcctttt taaagaccgt     9540

aaagaaaaat aagcacaagt tttatccggc ctttattcac attcttgccc gcctgatgaa     9600

tgctcatccg gaattccgta tggcaatgaa agacggtgag ctggtgatat gggatagtgt     9660

tcacccttgt tacaccgttt tccatgagca aactgaaacg ttttcatcgc tctggagtga     9720

ataccacgac gatttccggc agtttctaca catatattcg caagatgtgg cgtgttacgg     9780

tgaaaacctg gcctatttcc ctaaagggtt tattgagaat atgtttttcg tctcagccaa     9840

tccctgggtg agtttcacca gttttgattt aaacgtggcc aatatggaca acttcttcgc     9900

ccccgttttc accatgggca aatattatac gcaaggcgac aaggtgctga tgccgctggc     9960

gattcaggtt catcatgccg tctgtgatgg cttccatgtc ggcagaatgc ttaatgaatt    10020

acaacagtac tgcgatgagt ggcagggcgg ggcgtaattt ttttaaggca gttattggtg    10080

cccttaaacg cctggtgcta cgcctgaata agtgataata agcggatgaa tggcagaaat    10140

tcgaaagcaa attcgacc                                                  10158


<210>  62
<211>  10324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Operon OGO-9

<400>  62
cggtacatgt tcaccaccct gaattgactc tcttccgggc gctatcatgc cataccgcga       60

aaggttttgc gccattcgat ggtgtcctgg cacgacaggt ttcccgactg gaaagcgggc      120

agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca ggctttacac      180

tttatgcttc cggctcgtat aatgtgtgga attgtgagcg gataacaatt tcacacagga      240

aacaggatcg atccatcgat gagcttactc cccatccccc tgttgacaat taatcatcgg      300

ctcgtataat gtgtggaatt gtgagcggat aacaatttca cacaggaaac aggatcagct      360

tactccccat ccccctgttg acaattaatc atcggctcgt ataatgtgtg gaattgtgag      420

cggataacaa tttcacacag gaaacaggat ccatcgatgc ttaggaggtc agatgaaaat      480

cgaagaaggt aaactggtaa tctggattaa cggcgataaa ggctataacg gtctcgctga      540

agtcggtaag aaattcgaga aagataccgg aattaaagtc accgttgagc atccggataa      600

actggaagag aaattcccac aggttgcggc aactggcgat ggccctgaca ttatcttctg      660

ggcacacgac cgctttggtg gctacgctca atctggcctg ttggctgaaa tcaccccgga      720

caaagcgttc caggacaagc tgtatccgtt tacctgggat gccgtacgtt acaacggcaa      780

gctgattgct tacccgatcg ctgttgaagc gttatcgctg atttataaca aagatctgct      840

gccgaacccg ccaaaaacct gggaagagat cccggcgctg gataaagaac tgaaagcgaa      900

aggtaagagc gcgctgatgt tcaacctgca agaaccgtac ttcacctggc cgctgattgc      960

tgctgacggg ggttatgcgt tcaagtatga aaacggcaag tacgacatta aagacgtggg     1020

cgtggataac gctggcgcga aagcgggtct gaccttcctg gttgacctga ttaaaaacaa     1080

acacatgaat gcagacaccg attactccat cgcagaagct gcctttaata aaggcgaaac     1140

agcgatgacc atcaacggcc cgtgggcatg gtccaacatc gacaccagca aagtgaatta     1200

tggtgtaacg gtactgccga ccttcaaggg tcaaccatcc aaaccgttcg ttggcgtgct     1260

gagcgcaggt attaacgccg ccagtccgaa caaagagctg gcaaaagagt tcctcgaaaa     1320

ctatctgctg actgatgaag gtctggaagc ggttaataaa gacaaaccgc tgggtgccgt     1380

agcgctgaag tcttacgagg aagagttggc gaaagatcca cgtattgccg ccactatgga     1440

aaacgcccag aaaggtgaaa tcatgccgaa catcccgcag atgtccgctt tctggtatgc     1500

cgtgcgtact gcggtgatca acgccgccag cggtcgtcag actgtcgatg aagccctgaa     1560

agacgcgcag actaattcga gctcgaacaa caacaacaat aacaataaca acaacctcgg     1620

gatcgaggga aggatttcag agttcggttc caaaaagaaa gaccttcatc acagcaatgg     1680

agaagagaaa gcacaaagca tggagaccct ccctccaggg aaagtacggt ggccagactt     1740

taaccaggaa gcttatgttg gagggacgat ggtccgctcc gggcaggacc cttacgcccg     1800

caacaagttc aaccaggtgg agagtgataa gcttcgaatg gacagagcca tccctgacac     1860

ccggcatgac cagtgtcagc ggaagcagtg gcgggtggat ctgccggcca ccagcgtggt     1920

gatcacgttt cacaatgaag ccaggtcggc cctactcagg accgtggtca gcgtgcttaa     1980

gaaaagcccg ccccatctca taaaagaaat catcttggtg gatgactaca gcaatgatcc     2040

tgaggacggg gctctcttgg ggaaaattga gaaagtgcga gttcttagaa atgatcgacg     2100

agaaggcctc atgcgctcac gggttcgggg ggccgatgct gcccaagcca aggtcctgac     2160

cttcctggac agtcactgcg agtgtaatga gcactggctg gagcccctcc tggaaagggt     2220

ggcggaggac aggactcggg ttgtgtcacc catcatcgat gtcattaata tggacaactt     2280

tcagtatgtg ggggcatctg ctgacttgaa gggcggtttt gattggaact tggtattcaa     2340

gtgggattac atgacgcctg agcagagaag gtcccggcag gggaacccag tcgcccctat     2400

aaaaaccccc atgattgctg gtgggctgtt tgtgatggat aagttctatt ttgaagaact     2460

ggggaagtac gacatgatga tggatgtgtg gggaggagag aacctagaga tctcgttccg     2520

cgtgtggcag tgtggtggca gcctggagat catcccgtgc agccgtgtgg gacacgtgtt     2580

ccggaagcag cacccctaca cgttcccggg tggcagtggc actgtctttg cccgaaacac     2640

ccgccgggca gcagaggtct ggatggatga atacaaaaat ttctattatg cagcagtgcc     2700

ttctgctaga aacgttcctt atggaaatat tcagagcaga ttggagctta ggaagaaact     2760

cagctgcaag cctttcaaat ggtaccttga aaatgtctat ccagagttaa gggttccaga     2820

ccatcaggat atagcttttg gggccttgca gcagggaact aactgcctcg acactttggg     2880

acactttgct gatggtgtgg ttggagttta tgaatgtcac aatgctgggg gaaaccagga     2940

atgggccttg acgaaggaga agtcggtgaa gcacatggat ttgtgcctta ctgtggtgga     3000

ccgggcaccg ggctctctta taaagctgca gggctgccga gaaaatgaca gcagacagaa     3060

atgggaacag atcgagggca actccaagct gaggcacgtg ggcagcaacc tgtgcctgga     3120

cagtcgcacg gccaagagcg ggggcctaag cgtggaggtg tgtggcccgg ccctttcgca     3180

gcagtggaag ttcacgctca acctgcagca gtagtctagg tataagaagg agatatacat     3240

atgatgtcta aggcatccaa cagctggacg ggtaagggtc aagcatgtcg tcacctgctg     3300

catctggcta tccaacgtca ccctcacttc cgtggtctgt tcaacctgag catcccagtt     3360

ctgctgtggg gtgatctgtt cacgcctgca ctgtgggatc gtctgtctca gcataaagca     3420

ccgtatggtt ggcgtggtct gtctcatcag gtaatcgcat ctaccctgtc tctgctgaac     3480

ggtagcgaaa gcgctaagct gttcgctcca ccacgtgata ccccgccgaa atgtatccgt     3540

tgcgctgtag taggtaacgg tggtatcctg aacggttctc gtcagggtcc gaatatcgat     3600

gctcacgatt acgtcttccg tctgaatggc gctgtcatca agggcttcga gcgtgatgtg     3660

ggtaccaaaa cctccttcta cggcttcacc gtgaacacca tgaaaaacag cctggtgtcc     3720

tactggaacc tgggcttcac ctccgtgccg cagggtcagg atctgcagta tatcttcatc     3780

ccgtctgaca tccgtgacta cgttatgctg cgctccgcca tcctgggcgt tccggttccg     3840

gaaggcctgg ataaaggcga ccgcccgcat gcgtattttg gcccggaagc ctctgcgtct     3900

aaatttaaac tgctgcaccc ggactttatt tcttatctga ctgaacgctt cctgaaatcc     3960

aaactgatta acacccactt cggcgacctg tacatgccgt ccactggcgc gctgatgctg     4020

ctgactgccc tgcacacttg cgaccaggtt agcgcctatg gctttattac tagcaactac     4080

tggaaattca gcgaccacta ctttgagcgc aaaatgaaac cgctgatttt ttacgcgaac     4140

cacgacctgt ccctggaagc ggcgctgtgg cgcgacctgc acaaagcggg cattctgcag     4200

ctgtaccagc gctaagtcga gtctggtaaa gaaacaagga ggtattatga aaattcttat     4260

tagcggtggt gcaggttata taggttctca tactttaaga caatttttaa aaacagatca     4320

tgaaatttgt gttttagata atctttctaa gggttctaaa atcgcaatag aagatttgca     4380

aaaaacaaga gcttttaaat ttttcgaaca agatttaagt gattttcaag gcgtaaaagc     4440

attgtttgag agagaaaaat ttgacgctat tgtgcatttt gcagcaagca ttgaagtttt     4500

tgaaagtatg caaaatcctt taaaatatta tatgaacaac actgttaata cgacaaatct     4560

catcgaaact tgtttgcaaa ctggagtgaa taaatttata ttttcttcaa cggcggccac     4620

ttatggcgaa ccacaaactc ccgttgtgag cgaaacaagt cctttagcac ctattaatcc     4680

ttatgggcgt agtaagctta tgagtgaaga agttttgcgt gatgcaagta tggcaaatcc     4740

tgaatttaag cattgtattt taagatattt taatgttgca ggtgcttgta tggattatac     4800

tttaggacaa cgctatccaa aagcgacttt gcttataaaa gttgcagctg aatgtgccgc     4860

aggaaaacgt gataaacttt tcatatttgg cgatgattat gatacaaaag atggtacttg     4920

cataagagat tttatccatg tagatgatat ttcaagtgca catttagcgg ctttggatta     4980

tttaaaagag aatgaaagca atgtttttaa tgtaggttat ggacatggtt ttagcgtaaa     5040

agaagtgatt gaagcgatga aaaaagttag cggagtggat tttaaagtag aacttgcccc     5100

acgccgtgcg ggtgatccta gtgtattgat ttctgatgca agtaaaatca gaaatcttac     5160

ttcttggcag cctaaatatg atgatttaga gcttatttgt aaatctgctt ttgattggga     5220

aaaacagtgt taataagcat gcggaaacag tcgacaggag gtattatgga tgatgcggcg     5280

attcagcaga ccctggccaa aatgggcatt aaaagcagcg atattcagcc ggcaccggtg     5340

gcgggtatga aaaccgtgct gaccaacagc ggcgtgctgt atatcaccga tgatggcaaa     5400

catatcattc agggcccgat gtatgatgtg agcggcaccg caccggtgaa cgtgaccaac     5460

aaaatgctgc tgaaacagct gaacgcgctg gaaaaagaaa tgatcgtgta taaagcgccg     5520

caggaaaaac acgttattac cgtgtttacc gatattacct gcggctattg ccataaactg     5580

catgagcaaa tggcggatta taacgcgctg ggcattaccg tgcgttatct ggcctttccg     5640

cgtcagggcc tggatagcga tgccgaaaag gaaatgaaag cgatctggtg cgcgaaagat     5700

aaaaacaaag cgttcgatga tgtgatggcg ggcaaaagcg ttgcgccggc gagctgtgat     5760

gtggatattg cggatcatta tgcgctgggc gtgcagctgg gtgttagcgg caccccggcg     5820

gtggttctga gcaacggcac cctggtgccg ggttatcagc cgccgaaaga gatgaaagaa     5880

tttctggatg aacaccagaa aatgaccagc ggcaaataat ggcaaatatt ctgaaatgag     5940

ctgttgacaa ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc     6000

acacaggaaa cagccagtcc gtttaggtgt tttcacgagc aattgaccaa caaggaccat     6060

agattcatat gcgcccatgc acatgcactc gctgtattga agagcaacgc gtatccgcct     6120

ggtttgatga acgttttaat cgctccatgc agcctctgtt aaccgctaaa aacgcccatt     6180

tagaagaaga tacctataag tggtggctcc gcctgcaacg tgaaaaacaa cccaacaacc     6240

ttaacgacac cattcgcgaa ctgttccagg tagttcccgg taatgtggac ccactgttgg     6300

aaaaacgtct tgtttcatgt cgtcgttgcg ccgtagttgg caactcaggt aaccttaaag     6360

aaagctatta tggaccacaa attgattctc atgatttcgt attacgcatg aataaagccc     6420

ccacagaagg tttcgaagct gacgttggca gtaaaacaac ccaccatttt gtataccctg     6480

aatcctttcg cgaacttgcc caagaagttt ctatgatcct tgtaccgttt aaaactactg     6540

atctcgaatg ggtcatttca gcaactacta ccggtcgcat ttcccacacc tacgttcctg     6600

tacctgccaa aattaaagtc aaaaaagaaa aaattttaat ctaccaccca gcatttatta     6660

aatacgtgtt tgaccgttgg cttcaaggtc acggccgtta tccatccacc ggcatcttaa     6720

gcgtaatttt ttcactccac atctgcgatg aagtcgatct ctacggtttc ggggccgatt     6780

caaaaggaaa ctggcatcac tattgggaaa ataatccttc agctggcgca tttcgtaaaa     6840

ctggagttca tgatggagat ttcgaaagca atgtgaccac cattttagcc agtattaata     6900

agattcgcat ttttaaaggt cgctaagatc catcgatgct taggaggtca tatgatgttt     6960

aaaatttcaa tcatcttacc aacttataat gtggaacaat atatagcaag ggcaatagaa     7020

agctgtatca atcagacttt taaagatata gaaataattg tagttgatga ttgtggaaat     7080

gataatagta taaatatagc caaagaatac tctaaaaaag acaaaagaat aaaaataatc     7140

cacaatgaaa aaaacttagg tcttttaaga gcaagatatg aaggtgtgaa agtagcaaac     7200

tctccttata taatgttttt agatcctgat gattatttgg aactaaatgc ttgtgaagag     7260

tgtataaaaa ttttagatga acaggatgaa gttgatttag tgtttttcaa tgctattgtt     7320

gaaagtaatg ttatttcata taaaaagttt gactttaatt ctggttttta tagcaaaaaa     7380

gagtttgtaa aaaaaattat tgcaaagaaa aatttatatt ggactatgtg ggggaaactt     7440

ataagaaaga aattgtattt agaagctttt gcgagtttaa gactcgagaa agatgttaaa     7500

atcaatatgg ctgaagatgt attgttatat tatccaatgt taagtcaagc tcaaaaaata     7560

gcatatatga actgtaattt atatcattac gtgcctaata ataattcaat ttgtaatact     7620

aagaatgaag tgcttgttaa aaataatatt caagagttgc agttggtttt aaactattta     7680

aggcaaaatt atattttaaa caagtattgt agcgttctct atgtgctaat taaatatttg     7740

ctatatattc aaatatataa aataaaaccg tgagaattcc ctgatcgatg ataagctgtc     7800

aaacatgagc agatctgagc ccgcctaatg agcgggcttt tttttcagat ctgcttgaag     7860

acgaaagggc ctcgtgatac ggagctcgaa ttcactggcc gtcgttttac aacgtcgtga     7920

ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc ctttcgccag     7980

ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc gcagcctgaa     8040

tggcgaatgg cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg     8100

catctggtgc actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca     8160

cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag     8220

acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa     8280

acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat     8340

aatggtttct tagacgtcaa tattttatct gattaataag atgatcttct tgagatcgtt     8400

ttggtctgcg cgtaatctct tgctctgaaa acgaaaaaac cgccttgcag ggcggttttt     8460

cgaaggttct ctgagctacc aactctttga accgaggtaa ctggcttgga ggagcgcagt     8520

caccaaaact tgtcctttca gtttagcctt aaccggcgca tgacttcaag actaactcct     8580

ctaaatcaat taccagtggc tgctgccagt ggtgcttttg catgtctttc cgggttggac     8640

tcaagacgat agttaccgga taaggcgcag cggtcggact gaacgggggg ttcgtgcata     8700

cagtccagct tggagcgaac tgcctacccg gaactgagtg tcaggcgtgg aatgagacaa     8760

acgcggccat aacagcggaa tgacaccggt aaaccgaaag gcaggaacag gagagcgcac     8820

gagggagccg ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacca     8880

ctgatttgag cgtcagattt cgtgatgctt gtcagggggg cggagcctat ggaaaaacgg     8940

ctttgccgcg gccctctcac ttccctgtta agtatcttcc tggcatcttc caggaaatct     9000

ccgccccgtt cgtaagccat ttccgctcgc cgcagtcgaa cgaccgagcg tagcgagtca     9060

gtgagcgagg aagcggaata tatcctgtat cacatattct gctgacgcac cggtgcagcc     9120

ttttttctcc tgccacatga agcacttcac tgacaccctc atcagtgcca acatagtaag     9180

ccagtataca ctccgctagc gctgatgtcc ggcggtgctt ttgccgttac gcaccacccc     9240

gtcagtagct gaacaggagg gacagctgat agaaacagaa gccactggag cacctcaaaa     9300

acaccatcat acactaaatc agtaagttgg cagcatcacc cgacgcactt tgcgccgaat     9360

aaatacctgt gacggaagat cacttcgcag aataaataaa tcctggtgtc cctgttgata     9420

ccgggaagcc ctgggccaac ttttggcgaa aatgagacgt tgatcggcac gtaagaggtt     9480

ccaactttca ccataatgaa ataagatcac taccgggcgt attttttgag ttatcgagat     9540

tttcaggagc taaggaagct aaaatggaga aaaaaatcac tggatatacc accgttgata     9600

tatcccaatg gcatcgtaaa gaacattttg aggcatttca gtcagttgct caatgtacct     9660

ataaccagac cgttcagctg gatattacgg cctttttaaa gaccgtaaag aaaaataagc     9720

acaagtttta tccggccttt attcacattc ttgcccgcct gatgaatgct catccggaat     9780

tccgtatggc aatgaaagac ggtgagctgg tgatatggga tagtgttcac ccttgttaca     9840

ccgttttcca tgagcaaact gaaacgtttt catcgctctg gagtgaatac cacgacgatt     9900

tccggcagtt tctacacata tattcgcaag atgtggcgtg ttacggtgaa aacctggcct     9960

atttccctaa agggtttatt gagaatatgt ttttcgtctc agccaatccc tgggtgagtt    10020

tcaccagttt tgatttaaac gtggccaata tggacaactt cttcgccccc gttttcacca    10080

tgggcaaata ttatacgcaa ggcgacaagg tgctgatgcc gctggcgatt caggttcatc    10140

atgccgtctg tgatggcttc catgtcggca gaatgcttaa tgaattacaa cagtactgcg    10200

atgagtggca gggcggggcg taattttttt aaggcagtta ttggtgccct taaacgcctg    10260

gtgctacgcc tgaataagtg ataataagcg gatgaatggc agaaattcga aagcaaattc    10320

gacc                                                                 10324


<210>  63
<211>  3332
<212>  DNA
<213>  Neisseria meningitides


<220>
<221>  misc_feature
<222>  (1058)..(1058)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1991)..(1991)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2025)..(2025)
<223>  n is a, c, g, or t

<400>  63
cacgacaggt ttcccgactg gaaagcgggc agtgagcgca acgcaattaa tgtgagttag       60

ctcactcatt aggcacccca ggctttacac tttatgcttc cggctcgtat aatgtgtgga      120

attgtgagcg gataacaatt tcacacagga aacaggatcg atccatcgat gagcttactc      180

cccatccccc tgttgacaat taatcatcgg ctcgtataat gtgtggaatt gtgagcggat      240

aacaatttca cacaggaaac aggatcagct tactccccat ccccctgttg acaattaatc      300

atcggctcgt ataatgtgtg gaattgtgag cggataacaa tttcacacag gaaacaggat      360

ccatcgatgc ttaggaggtc atatgaaaag aattctttgc attacaggta ccagagccga      420

cttcggcaag ctaaaacctt tattagccta tattgaaaat cacccagacc ttgaattgca      480

tttgattgta actggtatgc acatgatgaa aacctatggc agaacctaca aggaagtaac      540

tcgagaaaac tatcaacata catatctgtt ttcaaatcaa atccaaggtg aaccaatggg      600

tgccgtttta ggcaatacca ttacgtttat ctctcgtcta tctgatgaaa ttgaacctga      660

tatggtcatg attcacggcg accgtttaga agcactagca ggcgcagctg taggtgcatt      720

aagcagccgt ttagtttgcc atatcgaagg tggtgaacta tctggtacag tagatgactc      780

cattcgtcat tctattagta aactttctca tatccacttg gtagcaaatg aacaagctgt      840

cactcgccta gtgcaaatgg gagaaaaaag aaagcatatt cacatcatcg gctcccccga      900

tttagatgtt atggcctctt ccaccctccc atccttagaa gaagtcaaag aatattacgg      960

tttaccatac gaaaattatg gtatttctat gtttcacccc gtgactacag aagcacattt     1020

aatgccacaa tatgcggccc aatatttcaa agcattanaa ttaagtggcc aaaatatcat     1080

tagcatctac cctaataatg acactggcac tgaaagtatt ctgcaagaat tattaaaata     1140

tcaatctgat aaatttattg catttccttc cattcgattt gaatattttt tagtcttatt     1200

gaaacatgct aaatttatgg tcggcaactc aagtgcaggt attagagaag ctcctctcta     1260

cggtgtccct tcaattgatg ttggtacacg ccaaagtaac cgccacatgg gaaaatctat     1320

tattcataca gattatgaaa ctaaaaatat ctttgatgcg attcaacaag catgtagttt     1380

aggcaaattt gaagcagatg atacctttaa tggcggagat actcgcacca gcacagaaag     1440

atttgctgaa gtaatcaaca atcctgaaac gtggaatgtt tctgctcaaa aacgttttat     1500

cgatttgaat ctttaaatta tggaaaaaca aaatattgcg gttatacttg cgcgccaaaa     1560

ctccaaagga ttgccattaa aaaatctccg gaaaatgaat ggcatatcat tacttggtca     1620

tacaattaat gctgctatat catcaaagtg ttttgaccgc ataattgttt cgactgatgg     1680

cgggttaatt gcagaagaag ctaaaaattt cggtgtcgaa gtcgtcctac gccctgcaga     1740

gctggcctcc gatacagcca gctctatttc aggtgtaata catgctttag aaacaattgg     1800

cagtaattcc ggcacagtaa ccctattaca accaaccagt ccattacgca caggggctca     1860

tattcgtgaa gctttttctc tatttgatga gaaaataaaa ggaagcgttg tctctgcatg     1920

tccaatggag catcatccac taaaaaccct gcttcaaatc aataatggcg aatatgcccc     1980

catgcgccat ntaagcgatt tggagcagcc tcgccaacaa ttacntcagg catttaggcc     2040

taatggtgca atttacatta atgatactgc ttcactaatt gcaaataatt gtttttttat     2100

cgccccaacc aaactttata ttatgtctca tcaagactct atcgatattg atactgagct     2160

tgatttacaa caggcagaaa acattcttaa tcacaaggaa agctaaatgc aaaacaacaa     2220

cgaatttaaa attggtaatc gttcagtagg ttacaaccac gaaccattga ttatctgtga     2280

aatcggcatc aatcatgaag gctctttaaa aacagctttt gaaatggttg atgctgccta     2340

taatgcaggc gctgaagttg ttaaacatca aacacacatc gttgaagacg aaatgtctga     2400

tgaggccaaa caagtcattc caggcaatgc agatgtctct atttatgaaa ttatggaacg     2460

ttgcgccctg aatgaagaag atgagattaa attaaaagaa tacgtagaga gtaagggtat     2520

gatttttatc agtactcctt tctctcgtgc agctgcttta cgattacaac gtatggatat     2580

tccagcatat aaaatcggct ctggcgaatg taataactac ccattaatta aactggtggc     2640

ctcttttggt aagcctatta ttctctctac cggcatgaat tctattgaaa gcatcaaaaa     2700

gtcggtagaa attattcgag aagcaggggt accttatgct ttgcttcact gtaccaacat     2760

ctacccaacc ccttacgaag atgttcgatt gggtggtatg aacgatttat ctgaagcctt     2820

tccagacgca atcattggcc tgtctgacca taccttagat aactatgctt gcttaggagc     2880

agtagcttta ggcggttcga ttttagagcg tcactttact gaccgcatgg atcgcccagg     2940

tccggatatt gtatgctcta tgaatccgga tacttttaaa gagctcaagc aaggcgctca     3000

tgctttaaaa ttggcacgcg gcggcaaaaa agacacgatt atcgcgggag aaaagccaac     3060

taaagatttc gcctttgcat ctgtcgtagc agataaagac attaaaaaag gagaactgtt     3120

gtccggagat aacctatggg ttaaacgccc aggcaatgga gacttcagcg tcaacgaata     3180

tgaaacatta tttggtaagg tcgctgcttg caatattcgc aaaggtgctc aaatcaaaaa     3240

aactgatatt gaataagtcg actctagagg atccccgggt accgagctcg aattcactgg     3300

ccgtcgtttt acaacgtcgt gactgggaaa ac                                   3332


<210>  64
<211>  1032
<212>  DNA
<213>  Drosophila melanogaster

<400>  64
atgagcgaat ttatgccgta tgatggtcac cgccatggtg atgttaatga tgcacatcat       60

agccacgaca tgatggaaat gagcggtccg gaacaggatg ttggtggtca tgaacatgtg      120

catgaaaata gcaccattgc agaacgtctg tatagcgaag ttcgtgttct gtgttggatt      180

atgaccaatc cgagcaacca tcagaaaaaa gcacgtcatg ttaaacgtac ctggggtaaa      240

cgttgcaaca aactgatttt tatgagcagc gccaaagatg atgaactgga tgcagttgca      300

ctgccggttg gtgaaggtcg taataatctg tggggtaaaa ccaaagaggc ctacaaatat      360

atctacgaac accatatcaa cgatgccgat tggtttctga aagcagatga tgatacctat      420

accatcgtgg aaaacatgcg ctatatgctg tatccgtata gtccggaaac accggtttat      480

tttggctgta aattcaaacc gtacgtgaaa cagggttata tgagcggtgg tgcaggttat      540

gttctgagcc gtgaagcagt tcgtcgtttt gttgttgaag cactgccgaa tccgaaactg      600

tgtaaaagcg ataatagcgg tgccgaagat gtggaaattg gtaaatgtct gcagaatgtt      660

aatgttctgg caggcgatag ccgtgatagc aatggtcgtg gtcgtttttt tccgtttgtg      720

ccggaacatc atctgattcc gagccatacc gacaaaaaat tctggtattg gcagtatatt      780

ttctataaaa ccgatgaagg cctggattgt tgtagcgata atgcaatcag ctttcattat      840

gttagcccga atcagatgta tgtgctggat tatctgatct atcatctgcg tccgtatggc      900

attattaaca caccggatgc cctgccgaat aaactggcag ttggtgaact gatgccggaa      960

attaaagaac aggcaaccga aagcaccagt gatggtgtta gcaaacgtag cgcagaaacc     1020

aaaacccagt aa                                                         1032


<210>  65
<211>  783
<212>  DNA
<213>  Campylobacter jejuni

<400>  65
atgaaaaaag ttattattgc tggaaatgga ccaagtttaa aagaaattga ttattcaaga       60

ctaccaaatg attttgatgt atttagatgt aatcaatttt attttgaaga taaatactat      120

cttggtaaaa aatgcaaggc agtattttac aatcctagtc ttttttttga acaatactac      180

actttaaaac atttaatcca aaatcaagaa tatgagaccg aactaattat gtgttctaat      240

tacaaccaag ctcatctaga aaatgaaaat tttgtaaaaa ctttttacga ttattttcct      300

gatgctcatt tgggatatga ttttttcaaa caacttaaag attttaatgc ttattttaaa      360

tttcacgaaa tttatttcaa tcaaagaatt acctcagggg tctatatgtg tgcagtagcc      420

atagccctag gatacaaaga aatttatctt tcgggaattg atttttatca aaatgggtca      480

tcttatgctt ttgatactaa acaaaaaaat cttttaaaat tggctcctaa ttttaaaaat      540

gataattcac actatattgg acatagtaaa aatacagata taaaagcttt agaatttcta      600

gaaaaaactt acaaaataaa actatattgc ttatgtccta acagtctttt agcaaatttt      660

atagaactag cgccaaattt aaattcaaat tttatcatac aagaaaaaaa taactacact      720

aaagatatac tcataccttc tagtgaggct tatggaaaat tttcaaaaaa tattaatttt      780

taa                                                                    783


<210>  66
<211>  3543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APO-3 hPDI-quescin-sulfydryl oxidase fusion protein (hPDI-QSOX1b)

<400>  66
atgtctgact ctgaagttaa ccaggaagct aaaccagaag ttaaaccgga agtgaaaccg       60

gaaacccaca tcaacctgaa agttagcgac ggctcttctg aaatcttctt taaaattaaa      120

aagaccactc cgctgcgtcg tctgatggaa gcgttcgcta aacgtcaggg taaagaaatg      180

gattctctgc gcttcctgta tgatggcatc cgtattcagg ctgaccaaac cccggaagat      240

ctggatatgg aagataacga tatcattgaa gcgcaccgtg aacaaatcgg cggcatggac      300

gcaccggaag aagaagacca cgtcctggtt ctgcgtaaat ctaacttcgc ggaagcgctg      360

gcggcgcaca aatacctgct ggttgaattc tacgcgccgt ggtgcggtca ctgcaaagct      420

ctggcgccgg aatacgctaa agccgctggc aaactgaaag ctgaaggttc cgaaatccgc      480

ttggctaaag tagacgcaac tgaagaatct gacctggcac agcagtacgg tgttcgtggc      540

tacccgacca tcaaattctt ccgtaacggt gacaccgcta gccctaagga atataccgca      600

ggccgtgaag ctgatgatat tgttaactgg ctgaaaaaac gtaccggccc ggcggcaacc      660

accctgcctg acggtgctgc ggctgaatcc ctggttgaat cttccgaagt cgcggtaatt      720

ggcttcttca aagatgtgga atctgatagc gctaaacagt tcctgcaggc cgctgaagca      780

atcgatgata tcccgttcgg tatcacctct aactctgacg tattctctaa ataccagctg      840

gataaagatg gcgtagttct gtttaaaaaa ttcgacgaag gtcgtaacaa cttcgaaggt      900

gaagtaacca aagaaaacct gctggacttc attaaacaca accagctgcc gctggttatt      960

gaattcaccg agcagactgc tcctaaaatc ttcggtggcg aaattaagac tcacatcctg     1020

ctgttcttgc cgaaaagcgt gtctgattac gacggtaaac tgagcaactt caaaaccgcg     1080

gcagagtctt tcaaaggtaa aatcttgttc atcttcatcg acagcgacca cactgataac     1140

cagcgtatcc tggaattctt cggtctgaag aaggaagaat gtccggcggt tcgcctgatc     1200

accctggaag aagaaatgac taaatataaa ccggagtctg aagaactgac tgctgaacgc     1260

atcaccgaat tctgccaccg ctttctggaa ggcaaaatca aaccgcacct gatgagccag     1320

gaactgccag aggactggga taaacagccg gttaaggtgc tggttggtaa aaactttgag     1380

gatgttgctt ttgacgaaaa gaaaaacgtg ttcgttgagt tctatgcgcc gtggtgcggc     1440

cactgcaaac agctggcacc gatctgggac aaactcggcg agacctacaa agatcatgag     1500

aacatcgtaa tcgcgaaaat ggactccacc gcgaatgaag ttgaagcagt taaagtgcac     1560

tctttcccga ccctgaaatt tttcccggcg tccgctgacc gtaccgtgat tgactacaac     1620

ggtgaacgca ccctggacgg ctttaaaaaa ttcctggaat ccggtggtca ggatggtgct     1680

ggtgatgatg acgatctgga agaccttgaa gaagctgaag agccggatat ggaagaagat     1740

gatgatcaga aggcggtgaa ggatgaactg ccgaccccga cccctaccac tccgactccg     1800

accccgacta ccgctccgcg ttctgcactg tacagcccat ctgacccact gaccctgctg     1860

caggcggata ccgttcgtgg cgccgtactg ggttcccgca gcgcctgggc ggttgaattc     1920

ttcgcgtcct ggtgtggcca ctgtatcgca ttcgctccga cttggaaagc gctggctgaa     1980

gatgttaaag cctggcgccc ggcgctgtac ctggcggcgc tggactgcgc ggaagaaact     2040

aactccgcag tgtgccgtga tttcaatatc ccaggtttcc cgaccgtacg cttctttaaa     2100

gcatttacca aaaacggttc cggcgcagta ttcccggtag caggtgctga tgttcagact     2160

ctgcgtgaac gtctgattga cgcgctggaa tctcaccatg acacctggcc accggcatgt     2220

ccgccgctgg aacctgccaa actggaggaa attgatggct tcttcgcgcg taacaacgaa     2280

gaatatctgg cactgatctt cgaaaagggc ggttcttacc tgggtcgcga agtggctctg     2340

gacctgagcc aacacaaagg tgttgctgtt cgtcgtgttc tgaacactga agcaaacgta     2400

gtgcgtaaat tcggtgtgac tgacttccct agctgctacc tgctgtttcg taacggttct     2460

gttagtcgtg ttccggttct gatggaatca cgctccttct acactgcata tctgcagcgc     2520

ctctccggtc tgacccgtga agccgcgcag accactgttg caccgaccac cgctaacaaa     2580

atcgcaccga ccgtttggaa gctcgccgac cgcagcaaga tctatatggc tgacctggaa     2640

tctgccttgc actacatcct gcgcattgaa gtaggtcgct tcccggtact ggagggccag     2700

cgcctggtcg cactgaaaaa attcgtagcg gtcctggcta aatatttccc tggtcgtccg     2760

ctggttcaga acttcctgca cagcgttaat gaatggctga aacgtcagaa acgtaacaaa     2820

atcccgtata gcttcttcaa aaccgcactg gatgaccgta aagaaggcgc ggtcctcgct     2880

aaaaaagtta actggattgg ttgccagggt agcgaaccgc atttccgtgg tttcccgtgc     2940

tctctgtggg tcctgttcca cttcctgact gtgcaggcgg ctcgccagaa cgtggaccac     3000

tctcaggaag ctgcgaaagc gaaagaagtc ctgccggcga tccgtggtta cgttcactac     3060

ttctttggct gtcgtgactg cgctagccac tttgaacaga tggcggccgc ttccatgcac     3120

cgtgtaggtt ccccgaacgc tgccgtgctg tggctgtggt ccagccacaa ccgtgttaac     3180

gctcgtctgg cgggtgcacc gtctgaagat ccgcagttcc cgaaagttca gtggccgccg     3240

cgtgaactgt gcagcgcttg ccataacgaa cgcctggacg tgccggtgtg ggacgttgaa     3300

gctaccctga acttcctgaa agctcacttc tctccgtcta acatcatcct cgacttcccg     3360

gcagcgggta gcgcggcacg tcgtgatgtt cagaacgttg cggcagctcc ggaactggcg     3420

atgggcgccc tggaactgga atcccgtaac tccaccctgg atccgggtaa accggaaatg     3480

atgaaatctc cgaccaacac caccccgcac gttccggctg aaggtccgga actgatctaa     3540

taa                                                                   3543


<210>  67
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS23-IF

<400>  67
gggatcggaa ttcgagctcc acgacaggtt tcccgactg                              39


<210>  68
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS23-VR

<400>  68
cagtcgggaa acctgtcgtg gagctcgaat tccgatccc                              39


<210>  69
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS23-VF

<400>  69
caacgtcgtg actgggaaaa ccatggcgcc taacctaaac tgac                        44


<210>  70
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS23-IR

<400>  70
gtcagtttag gttaggcgcc atggttttcc cagtcacgac gttg                        44


<210>  71
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS24_F

<400>  71
gaaggagata taccatgaca aggactagaa tg                                     32


<210>  72
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS24_R

<400>  72
cattctagtc cttgtcatgg tatatctcct tc                                     32


<210>  73
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS19-VF

<400>  73
tatattcaaa tatataaaat aaaaccgtga gaattccctg caggtaatta aataagcttc       60


<210>  74
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS19-VR

<400>  74
gagtgcatgt gcatgggcgc atatgtgaaa tccttccctc gatcc                       45


<210>  75
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS19-1F

<400>  75
ggatcgaggg aaggatttca catatgcgcc catgcacatg cactc                       45


<210>  76
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS19-1R

<400>  76
ctcctaagca tcgatggatc ttagcgacct ttaaaaatgc gaatcttatt                  50


<210>  77
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS19-2F

<400>  77
aataagattc gcatttttaa aggtcgctaa gatccatcga tgcttaggag                  50


<210>  78
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS19-2R

<400>  78
gaagcttatt taattacctg cagggaattc tcacggtttt attttatata tttgaatata       60


<210>  79
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS25_VF

<400>  79
taaaaccgtg agaattccct gatcgatgat aagctgtcaa acatg                       45


<210>  80
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS25_VaR_VF

<400>  80
catccataat acctcctgtc gactgtttcc gcatgcttat taac                        44


<210>  81
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS25_IaF

<400>  81
gttaataagc atgcggaaac agtcgacagg aggtattatg gatg                        44


<210>  82
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS25_IaR

<400>  82
gctcatttca gaatatttgc cattatttgc cgctggtcat ttt                         43


<210>  83
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS25_IbF

<400>  83
aaaatgacca gcggcaaata atggcaaata ttctgaaatg agc                         43


<210>  84
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS25_IR

<400>  84
catgtttgac agcttatcat cgatcaggga attctcacgg tttta                       45


<210>  85
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS25_IbF

<400>  85
aattgaccaa caaggaccat agattcatat gcgcccatgc acat                        44


<210>  86
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS25_VbR

<400>  86
atgtgcatgg gcgcatatga atctatggtc cttgttggtc aatt                        44


<210>  87
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS26_IF

<400>  87
attgaccaac aaggaccata gattatgttt aaaatttcaa tcatcttacc a                51


<210>  88
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS26_IR

<400>  88
gctcatgttt gacagcttat cattctgcag gtcgacttat ttgtt                       45


<210>  89
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS26_VF

<400>  89
aacaaataag tcgacctgca gaatgataag ctgtcaaaca tgagc                       45


<210>  90
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS26_VR

<400>  90
tggtaagatg attgaaattt taaacataat ctatggtcct tgttggtcaa t                51


<210>  91
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS47_VF

<400>  91
gattcgcatt tttaaaggtc gctaaatcga tgataagctg tcaaacatga g                51


<210>  92
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS47_VR

<400>  92
cgctcatatg tatatctcct tcttaaagct agactactgc tgcaggttga g                51


<210>  93
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS47_1F

<400>  93
ctcaacctgc agcagtagtc tagctttaag aaggagatat acatatgagc g                51


<210>  94
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS47_1R

<400>  94
cgctaataag aattttcata atacctcctt ttactgggtt ttggtttctg cg               52


<210>  95
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS47_2F

<400>  95
cgcagaaacc aaaacccagt aaaaggaggt attatgaaaa ttcttattag cg               52


<210>  96
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS47_2R

<400>  96
ctcatgtttg acagcttatc atcgatttag cgacctttaa aaatgcgaat c                51


<210>  97
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS44-IF

<400>  97
ctcaacctgc agcagtagtc taggtataag aaggagatat acatatgacc tgc              53


<210>  98
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS44_VR

<400>  98
gcaggtcata tgtatatctc cttcttatac ctagactact gctgcaggtt gag              53


<210>  99
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS44_VF

<400>  99
gtcgagtctg gtaaagaaac cgaaggaggt attatgaaaa ttcttattag cg               52


<210>  100
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS44_IR

<400>  100
cgctaataag aattttcata atacctcctt cggtttcttt accagactcg ac               52


<210>  101
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS45_IF

<400>  101
ctcaacctgc agcagtagtc taggtataag aaggagatat acatatgatg tctaagg          57


<210>  102
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS45_VR

<400>  102
ccttagacat catatgtata tctccttctt atacctagac tactgctgca ggttgag          57


<210>  103
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS45b_VF

<400>  103
gctaagtcga gtctggtaaa gaaacaagga ggtattatga aaattcttat tagcg            55


<210>  104
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS45b_IR

<400>  104
cgctaataag aattttcata atacctcctt gtttctttac cagactcgac ttagc            55


<210>  105
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS39_IF

<400>  105
ataaaaccgt gagaattccc tggtataaga aggagatata catatgaaaa aag              53


<210>  106
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS39_VR

<400>  106
cttttttcat atgtatatct ccttcttata ccagggaatt ctcacggttt tat              53


<210>  107
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS39_VF

<400>  107
caaaaaatat taatttttaa gtcgagtctg gatcgatgat aagctgtcaa acatg            55


<210>  108
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer LS39_IR

<400>  108
catgtttgac agcttatcat cgatccagac tcgacttaaa aattaatatt ttttg            55


