                         SEQUENCE LISTING

<110>  Monash University
 
<120>  Anti-mullerian hormone polypeptides

<130>  530671PCT

<150>  AU2019904097
<151>  2019-10-30

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Asp Leu Pro Leu Thr Ser Leu Ala Leu Val Leu Ser Ala Leu 
1               5                   10                  15      


Gly Ala Leu Leu Gly Thr Glu Ala Leu Arg Ala Glu Glu Pro Ala Val 
            20                  25                  30          


Gly Thr Ser Gly Leu Ile Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly 
        35                  40                  45              


Ser Pro Gln Glu Pro Leu Cys Leu Val Ala Leu Gly Gly Asp Ser Asn 
    50                  55                  60                  


Gly Ser Ser Ser Pro Leu Arg Val Val Gly Ala Leu Ser Ala Tyr Glu 
65                  70                  75                  80  


Gln Ala Phe Leu Gly Ala Val Gln Arg Ala Arg Trp Gly Pro Arg Asp 
                85                  90                  95      


Leu Ala Thr Phe Gly Val Cys Asn Thr Gly Asp Arg Gln Ala Ala Leu 
            100                 105                 110         


Pro Ser Leu Arg Arg Leu Gly Ala Trp Leu Arg Asp Pro Gly Gly Gln 
        115                 120                 125             


Arg Leu Val Val Leu His Leu Glu Glu Val Thr Trp Glu Pro Thr Pro 
    130                 135                 140                 


Ser Leu Arg Phe Gln Glu Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu 
145                 150                 155                 160 


Leu Ala Leu Leu Val Leu Tyr Pro Gly Pro Gly Pro Glu Val Thr Val 
                165                 170                 175     


Thr Arg Ala Gly Leu Pro Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp 
            180                 185                 190         


Thr Arg Tyr Leu Val Leu Ala Val Asp Arg Pro Ala Gly Ala Trp Arg 
        195                 200                 205             


Gly Ser Gly Leu Ala Leu Thr Leu Gln Pro Arg Gly Glu Asp Ser Arg 
    210                 215                 220                 


Leu Ser Thr Ala Arg Leu Gln Ala Leu Leu Phe Gly Asp Asp His Arg 
225                 230                 235                 240 


Cys Phe Thr Arg Met Thr Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu 
                245                 250                 255     


Pro Ala Pro Leu Pro Ala His Gly Gln Leu Asp Thr Val Pro Phe Pro 
            260                 265                 270         


Pro Pro Arg Pro Ser Ala Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp 
        275                 280                 285             


Pro Phe Leu Glu Thr Leu Thr Arg Leu Val Arg Ala Leu Arg Val Pro 
    290                 295                 300                 


Pro Ala Arg Ala Ser Ala Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu 
305                 310                 315                 320 


Ala Gly Phe Pro Gln Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu 
                325                 330                 335     


Glu Arg Leu Leu Asp Gly Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro 
            340                 345                 350         


Thr Ala Ala Thr Thr Gly Asp Pro Ala Pro Leu His Asp Pro Thr Ser 
        355                 360                 365             


Ala Pro Trp Ala Thr Ala Leu Ala Arg Arg Val Ala Ala Glu Leu Gln 
    370                 375                 380                 


Ala Ala Ala Ala Glu Leu Arg Ser Leu Pro Gly Leu Pro Pro Ala Thr 
385                 390                 395                 400 


Ala Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly 
                405                 410                 415     


Gly Leu Gly Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln 
            420                 425                 430         


Gly Leu Arg Val Glu Trp Arg Gly Arg Asp Pro Arg Gly Pro Gly Arg 
        435                 440                 445             


Ala Gln Arg Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu 
    450                 455                 460                 


Arg Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro 
465                 470                 475                 480 


Glu Thr Tyr Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln 
                485                 490                 495     


Ser Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys 
            500                 505                 510         


Met Gln Ala Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro 
        515                 520                 525             


Thr Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile 
    530                 535                 540                 


Ser Ala His His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
545                 550                 555                 560 


<210>  2
<211>  554
<212>  PRT
<213>  Mus musculus

<400>  2

Met Gln Gly Pro His Leu Ser Pro Leu Val Leu Leu Leu Ala Thr Met 
1               5                   10                  15      


Gly Ala Val Leu Gln Pro Glu Ala Val Glu Asn Leu Ala Thr Asn Thr 
            20                  25                  30          


Arg Gly Leu Ile Phe Leu Glu Asp Glu Leu Trp Pro Pro Ser Ser Pro 
        35                  40                  45              


Pro Glu Pro Leu Cys Leu Val Thr Val Arg Gly Glu Gly Asn Thr Ser 
    50                  55                  60                  


Arg Ala Ser Leu Arg Val Val Gly Gly Leu Asn Ser Tyr Glu Tyr Ala 
65                  70                  75                  80  


Phe Leu Glu Ala Val Gln Glu Ser Arg Trp Gly Pro Gln Asp Leu Ala 
                85                  90                  95      


Thr Phe Gly Val Cys Ser Thr Asp Ser Gln Ala Thr Leu Pro Ala Leu 
            100                 105                 110         


Gln Arg Leu Gly Ala Trp Leu Gly Glu Thr Gly Glu Gln Gln Leu Leu 
        115                 120                 125             


Val Leu His Leu Ala Glu Val Ile Trp Glu Pro Glu Leu Leu Leu Lys 
    130                 135                 140                 


Phe Gln Glu Pro Pro Pro Gly Gly Ala Ser Arg Trp Glu Gln Ala Leu 
145                 150                 155                 160 


Leu Val Leu Tyr Pro Gly Pro Gly Pro Gln Val Thr Val Thr Gly Thr 
                165                 170                 175     


Gly Leu Arg Gly Thr Gln Asn Leu Cys Pro Thr Arg Asp Thr Arg Tyr 
            180                 185                 190         


Leu Val Leu Thr Val Asp Phe Pro Ala Gly Ala Trp Ser Gly Ser Gly 
        195                 200                 205             


Leu Ile Leu Thr Leu Gln Pro Ser Arg Glu Gly Ala Thr Leu Ser Ile 
    210                 215                 220                 


Asp Gln Leu Gln Ala Phe Leu Phe Gly Ser Asp Ser Arg Cys Phe Thr 
225                 230                 235                 240 


Arg Met Thr Pro Thr Leu Val Val Leu Pro Pro Ala Glu Pro Ser Pro 
                245                 250                 255     


Gln Pro Ala His Gly Gln Leu Asp Thr Met Pro Phe Pro Gln Pro Gly 
            260                 265                 270         


Leu Ser Leu Glu Pro Glu Ala Leu Pro His Ser Ala Asp Pro Phe Leu 
        275                 280                 285             


Glu Thr Leu Thr Arg Leu Val Arg Ala Leu Arg Gly Pro Leu Thr Gln 
    290                 295                 300                 


Ala Ser Asn Thr Gln Leu Ala Leu Asp Pro Gly Ala Leu Ala Ser Phe 
305                 310                 315                 320 


Pro Gln Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu Gly Arg Leu 
                325                 330                 335     


Leu Asp Trp Glu Glu Pro Leu Leu Leu Leu Leu Ser Pro Ala Ala Ala 
            340                 345                 350         


Thr Glu Arg Glu Pro Met Pro Leu His Gly Pro Ala Ser Ala Pro Trp 
        355                 360                 365             


Ala Ala Gly Leu Gln Arg Arg Val Ala Val Glu Leu Gln Ala Ala Ala 
    370                 375                 380                 


Ser Glu Leu Arg Asp Leu Pro Gly Leu Pro Pro Thr Ala Pro Pro Leu 
385                 390                 395                 400 


Leu Ala Arg Leu Leu Ala Leu Cys Pro Asn Asp Ser Arg Ser Ser Gly 
                405                 410                 415     


Asp Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg 
            420                 425                 430         


Ala Glu Trp His Gly Arg Glu Gly Arg Gly Arg Thr Gly Arg Ser Ala 
        435                 440                 445             


Gly Thr Gly Thr Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser Val Asp 
    450                 455                 460                 


Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln Ala Asn 
465                 470                 475                 480 


Asn Cys Gln Gly Ala Cys Ala Trp Pro Gln Ser Asp Arg Asn Pro Arg 
                485                 490                 495     


Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala Arg Gly Ala 
            500                 505                 510         


Ala Leu Gly Arg Leu Pro Cys Cys Val Pro Thr Ala Tyr Ala Gly Lys 
        515                 520                 525             


Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His His Val Pro 
    530                 535                 540                 


Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
545                 550                 


<210>  3
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified AMH precursor

<400>  3

Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Ile Ser Gly Ser Ala 
1               5                   10                  15      


Phe Ser His His His His His His Pro Ala Val Gly Thr Ser Gly Leu 
            20                  25                  30          


Ile Phe Arg Glu Asp Leu Asp Trp Pro Pro Gly Ser Pro Gln Glu Pro 
        35                  40                  45              


Leu Cys Leu Val Ala Leu Gly Gly Asp Ser Asn Gly Ser Ser Ser Pro 
    50                  55                  60                  


Leu Arg Val Val Gly Ala Leu Ser Ala Tyr Glu Gln Ala Phe Leu Gly 
65                  70                  75                  80  


Ala Val Gln Arg Ala Arg Trp Gly Pro Arg Asp Leu Ala Thr Phe Gly 
                85                  90                  95      


Val Cys Asn Thr Gly Asp Arg Gln Ala Ala Leu Pro Ser Leu Arg Arg 
            100                 105                 110         


Leu Gly Ala Trp Leu Gln Asp Pro Gly Gly Gln Arg Leu Val Val Leu 
        115                 120                 125             


His Leu Glu Glu Val Thr Trp Glu Pro Thr Pro Ser Leu Arg Phe Gln 
    130                 135                 140                 


Glu Pro Pro Pro Gly Gly Ala Gly Pro Pro Glu Leu Ala Leu Leu Val 
145                 150                 155                 160 


Leu Tyr Pro Gly Pro Gly Pro Glu Val Thr Val Thr Arg Ala Gly Leu 
                165                 170                 175     


Pro Gly Ala Gln Ser Leu Cys Pro Ser Arg Asp Thr Arg Tyr Leu Val 
            180                 185                 190         


Leu Ala Val Asp Arg Pro Ala Gly Ala Trp Arg Gly Ser Gly Leu Ala 
        195                 200                 205             


Leu Thr Leu Gln Pro Arg Gly Glu Asp Ser Arg Leu Ser Thr Ala Arg 
    210                 215                 220                 


Leu Gln Ala Leu Leu Phe Gly Asp Asp His Arg Cys Phe Thr Arg Met 
225                 230                 235                 240 


Thr Pro Ala Leu Leu Leu Leu Pro Arg Ser Glu Pro Ala Pro Leu Pro 
                245                 250                 255     


Ala His Gly Gln Leu Asp Thr Val Pro Phe Pro Pro Pro Arg Pro Ser 
            260                 265                 270         


Ala Glu Leu Glu Glu Ser Pro Pro Ser Ala Asp Pro Phe Leu Glu Thr 
        275                 280                 285             


Leu Thr Arg Leu Val Arg Ala Leu Arg Val Pro Pro Ala Arg Ala Ser 
    290                 295                 300                 


Ala Pro Arg Leu Ala Leu Asp Pro Asp Ala Leu Ala Gly Phe Pro Gln 
305                 310                 315                 320 


Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Leu Glu Arg Leu Leu Asp 
                325                 330                 335     


Gly Glu Glu Pro Leu Leu Leu Leu Leu Arg Pro Thr Ala Ala Thr Thr 
            340                 345                 350         


Gly Asp Pro Ala Pro Leu His Asp Pro Thr Ser Ala Pro Trp Ala Thr 
        355                 360                 365             


Ala Leu Ala Arg Arg Val Ala Ala Glu Leu Gln Ala Ala Ala Ala Glu 
    370                 375                 380                 


Leu Arg Ser Leu Pro Gly Leu Pro Pro Ala Thr Ala Pro Leu Leu Ala 
385                 390                 395                 400 


Arg Leu Leu Ala Leu Cys Pro Gly Gly Pro Gly Gly Leu Gly Asp Pro 
                405                 410                 415     


Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg Val Glu 
            420                 425                 430         


Trp Arg Gly Arg Asp Pro Arg Gly Pro Gly Ile Ser Ser Arg Lys Lys 
        435                 440                 445             


Arg Ser Val Ser Ser Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys 
    450                 455                 460                 


Ala Leu Arg Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu 
465                 470                 475                 480 


Ile Pro Glu Thr Tyr Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp 
                485                 490                 495     


Pro Gln Ser Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu 
            500                 505                 510         


Leu Lys Met Gln Ala Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys 
        515                 520                 525             


Val Pro Thr Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu 
    530                 535                 540                 


Arg Ile Ser Ala His His Val Pro Asn Met Val Ala Thr Glu Cys Gly 
545                 550                 555                 560 


Cys Arg 
        


<210>  4
<211>  1689
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified AMH precursor

<400>  4
atgaagtggg taacctttct cctcctcctc ttcatctccg gttctgcctt ttcccatcat       60

catcatcatc atccagctgt gggcaccagt ggcctcatct tccgagaaga cttggactgg      120

cctccaggca gcccacaaga gcctctgtgc ctggtggcac tgggcgggga cagcaatggc      180

agcagctccc ccctgcgggt ggtgggggct ctaagcgcct atgagcaggc cttcctgggg      240

gctgtgcaga gggcccgctg gggcccccga gacctggcca ccttcggggt ctgcaacacc      300

ggtgacaggc aggctgcctt gccctctcta cggcggctgg gggcctggct gcaggaccct      360

ggggggcagc gcctggtggt cctacacctg gaggaagtga cctgggagcc aacaccctcg      420

ctgaggttcc aggagccccc gcctggagga gctggccccc cagagctggc gctgctggtg      480

ctgtaccctg ggcctggccc tgaggtcact gtgacgaggg ctgggctgcc aggtgcccag      540

agcctctgcc cctcccgaga cacccgctac ctggtgttag cggtggaccg ccctgcgggg      600

gcctggcgcg gctccgggct ggccttgacc ctgcagcccc gcggagagga ctcccggctg      660

agtaccgccc ggctgcaggc actgctgttc ggcgacgacc accgctgctt cacacggatg      720

accccggccc tgctcctgct gccgcggtcc gagcccgcgc cgctgcctgc gcacggccag      780

ctggacaccg tgcccttccc gccgcccagg ccatccgcgg aactggagga gtcgccaccc      840

agcgcagacc ccttcctgga gacgctcacg cgcctggtgc gggcgctgcg ggtccccccg      900

gcccgggcct ccgcgccgcg cctggccctg gatccggacg cgctggccgg cttcccgcag      960

ggcctagtca acctgtcgga ccccgcggcg ctggagcgcc tactcgacgg cgaggagccg     1020

ctgctgctgc tgctgaggcc cactgcggcc accaccgggg atcctgcgcc cctgcacgac     1080

cccacgtcgg cgccgtgggc cacggccctg gcgcgccgcg tggctgctga actgcaagcg     1140

gcggctgccg agctgcgaag cctcccgggt ctgcctccgg ccacagcccc gctgctggcg     1200

cgcctgctcg cgctctgtcc aggaggcccc ggcggcctcg gcgatcccct gcgagcgctg     1260

ctgctcctga aggcgctgca gggcctgcgc gtggagtggc gcgggcggga tccgcgcggg     1320

ccgggtatct catcgagaaa gaaacgctca gtctcatcaa gcgcgggggc caccgccgcc     1380

gacgggccgt gcgcgctgcg cgagctcagc gtagacctcc gcgccgagcg ctccgtactc     1440

atccccgaga cctaccaggc caacaattgc cagggcgtgt gcggctggcc tcagtccgac     1500

cgcaacccgc gctacggcaa ccacgtggtg ctgctgctga agatgcaggc ccgtggggcc     1560

gccctggcgc gcccaccctg ctgcgtgccc accgcctacg cgggcaagct gctcatcagc     1620

ctgtcggagg agcgcatcag cgcgcaccac gtgcccaaca tggtggccac cgagtgtggc     1680

tgccggtaa                                                             1689


<210>  5
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified mature AMH sequence

<400>  5

Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
1               5                   10                  15      


Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
            20                  25                  30          


Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser Asp Arg 
        35                  40                  45              


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
    50                  55                  60                  


Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr 
65                  70                  75                  80  


Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
                85                  90                  95      


His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            100                 105                 


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  processing site

<400>  6

Ile Ser Ser Arg Lys Lys Arg Ser Val Ser Ser 
1               5                   10      


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  7

Met Arg Asp Leu Pro Leu Thr Ser Leu Ala Leu Val Leu Ser Ala Leu 
1               5                   10                  15      


Gly Ala Leu Leu Gly Thr Glu Ala Leu 
            20                  25  


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  8

Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Ile Ser Gly Ser Ala 
1               5                   10                  15      


Phe Ser 
        


<210>  9
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMH analogue

<400>  9

Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
1               5                   10                  15      


Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
            20                  25                  30          


Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser Asp Arg 
        35                  40                  45              


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
    50                  55                  60                  


Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr 
65                  70                  75                  80  


Ala Lys Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
                85                  90                  95      


His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            100                 105                 


<210>  10
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMH analogue

<400>  10

Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
1               5                   10                  15      


Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
            20                  25                  30          


Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser Asp Arg 
        35                  40                  45              


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
    50                  55                  60                  


Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr 
65                  70                  75                  80  


Ala Ser Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
                85                  90                  95      


His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            100                 105                 


<210>  11
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMH analogue

<400>  11

Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
1               5                   10                  15      


Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
            20                  25                  30          


Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser Asp Arg 
        35                  40                  45              


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
    50                  55                  60                  


Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr 
65                  70                  75                  80  


Ala Ala Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
                85                  90                  95      


His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            100                 105                 


<210>  12
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMH analogue

<400>  12

Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
1               5                   10                  15      


Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
            20                  25                  30          


Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser Asp Arg 
        35                  40                  45              


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
    50                  55                  60                  


Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr 
65                  70                  75                  80  


Ala His Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
                85                  90                  95      


His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            100                 105                 


<210>  13
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMH analogue

<400>  13

Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
1               5                   10                  15      


Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
            20                  25                  30          


Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser Asp Arg 
        35                  40                  45              


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
    50                  55                  60                  


Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr 
65                  70                  75                  80  


Ala Gly Lys Met Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
                85                  90                  95      


His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            100                 105                 


<210>  14
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMH analogue

<400>  14

Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
1               5                   10                  15      


Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
            20                  25                  30          


Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser Asp Arg 
        35                  40                  45              


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
    50                  55                  60                  


Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr 
65                  70                  75                  80  


Ala Ala Lys Met Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
                85                  90                  95      


His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            100                 105                 


<210>  15
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMH analogue

<400>  15

Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
1               5                   10                  15      


Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
            20                  25                  30          


Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro Gln Ser Asp Arg 
        35                  40                  45              


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
    50                  55                  60                  


Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr 
65                  70                  75                  80  


Ala Ala Lys Met Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
                85                  90                  95      


Lys Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            100                 105                 


<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  16

Met Lys Val Ser Val Ala Ala Leu Ser Cys Leu Met Leu Val Thr Ala 
1               5                   10                  15      


Leu Gly Ser Gln Ala 
            20      


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  17

Met Leu Gln Asn Ser Ala Val Leu Leu Leu Leu Val Ile Ser Ala Ser 
1               5                   10                  15      


Ala 
    


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  18

Met Leu Leu Gln Ala Phe Leu Phe Leu Leu Ala Gly Phe Ala Ala Lys 
1               5                   10                  15      


Ile Ser Ala 
            


<210>  19
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  19

Met Lys Trp Val Ser Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Ser Leu Glu Lys Arg 
            20                  


<210>  20
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  20

Met Lys Trp Val Ser Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Ser Leu Asp Lys Arg 
            20                  


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  21

Met Asn Ile Phe Tyr Ile Phe Leu Phe Leu Leu Ser Phe Val Gln Gly 
1               5                   10                  15      


Ser Leu Asp Lys Arg 
            20      


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  22

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  23

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala 
            20                  25                  


<210>  24
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  24

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly 
            20          


<210>  25
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal sequence

<400>  25

Met Leu Pro Leu Cys Leu Val Ala Ala Leu Leu Leu Ala Ala Gly Pro 
1               5                   10                  15      


Gly Pro Ser Leu Gly 
            20      


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  26

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  27
<211>  1665
<212>  DNA
<213>  Mus musculus

<400>  27
atgcaggggc cacacctctc tccactggta ctgctgctag cgactatggg ggctgtgtta       60

cagcctgagg cggttgaaaa cctggccacc aataccaggg gcctcatctt ccttgaagat      120

gagctctggc cccccagcag cccccctgaa cctttgtgcc tggtgacagt gagaggagag      180

gggaacacaa gcagagcttc cctgagggtg gtggggggtc tgaacagcta tgagtatgcc      240

ttcctggagg ctgtccagga gtctcgctgg ggaccccaag acctggccac cttcggagtc      300

tgcagcactg actcccaggc taccctgcct gccctgcagc gccttggggc ctggctaggg      360

gagactggag aacagcagtt gctagtccta catctggctg aagtgatatg ggagcccgag      420

ctcttgctga agttccaaga gcctccacct gggggagcca gccgctggga gcaggccctg      480

ttagtgctat accctggacc aggcccccag gtcacagtca cagggactgg actgcggggc      540

acacagaacc tctgccctac tcgggacacc cgctatttgg tgctaaccgt ggacttccca      600

gcgggggcct ggagcggctc gggcctcatc ttaacccttc aaccaagcag agaaggtgcc      660

accctgagca tcgatcagct gcaagccttt ctatttggct ctgattcccg ctgtttcacg      720

cggatgactc ccaccctggt ggtgctgcca cccgccgagc cgtcaccgca gccagcacac      780

ggccagctgg acaccatgcc tttcccgcag cctggactgt ccctggagcc tgaggccctg      840

ccacacagcg ccgacccctt cctagagacc ctcactcgct tggttcgtgc tctgcgggga      900

cctctgaccc aggcttcgaa cacgcaactg gccctggacc ctggtgcgct ggccagcttc      960

ccacagggcc tggtcaacct gtcagacccc gcagcactgg gacgcctgct cgactgggag     1020

gaacccctat tactgctgct gtcacccgct gcggccacgg agagggaacc tatgccgctg     1080

cacggccccg cttctgctcc ctgggcagcg ggcctgcaac gcagggtggc agtggagctg     1140

caggcggcag cctcagagct gcgggacctc ccgggtctgc cacccacagc tcccccgctg     1200

ctggcgcgcc tgctagcgct gtgtcccaac gactcccgca gctccgggga cccgctgcgc     1260

gcgctgctgc tgctaaaggc gctgcagggc ttacgtgccg agtggcatgg gcgggaaggg     1320

cgtgggagaa cggggcgcag cgcggggaca gggacagacg ggccttgcgc gctgcgcgag     1380

ctgagtgtag atctgcgcgc ggagcgttca gtgctcatcc cggagaccta ccaagccaac     1440

aactgccaag gcgcctgcgc gtggccgcag tctgaccgta atccgcgcta cgggaaccac     1500

gtggtgctgc tgctaaaaat gcaggctcgc ggggctgccc tgggccgcct gccctgctgc     1560

gtgcccactg cctacgcggg caagctgctc atcagcctgt ccgaggagcg catcagcgcg     1620

caccacgtgc ccaacatggt agccaccgag tgcggctgcc ggtga                     1665


<210>  28
<211>  1722
<212>  DNA
<213>  Equus caballus

<400>  28
atgcgggctc cgtctctctc gtggctggcg cttgtgctgt cagctgtggg ggctctgctg       60

agggccggga cccccggaga agaggtctcc agcaccccag ctttgcctgg ggagccagcc      120

acaggcaccg ggggcctcat cttccaccag gactgggact ggccgccagg cagcccccaa      180

gaacccctgg ggtgcttggt gacgctggac gagggtggca accagagcag cgccccgctg      240

cgggtggcgg gggccctgag cggctacgag caggccttcc tggaggccgt gcagcgcacc      300

cactggagcc cccgcgacct gcccaccttc ggggtctgct cccctgccga ccggcaggcg      360

gccgtaccat ctctgcagcg cctgcaggcc tggctggggg caccctgggg gcagcggctg      420

gtggtcctgc acctggagga agtgatgtgg gagccgacgc cctcgctgag gttccaggag      480

cccccatctg gaggagccaa ccccctggag ccagcgctgc tggtgctgta cgccgggccc      540

ggccctgagg tcactgtcac gggggccggg ctgccagggg cccagagcct ctgcccgtcc      600

ccggacaccc gctacctggc gctggccgtc gaccacccag cacgggcctg gcgccaccct      660

gggctcatcc tgaccctgca gcctcgcgga gacggtgccc ccctgagcac ggcccagctg      720

cagacgctgc tgttcggcgc cgacccccgc tgcttcacgc ggatgacccc cgccctgttc      780

ctgctgcagc ggccggggcc cgcgcccatg cccgcgcacg gccgactcga cacggtgccc      840

ttcccgccag ccaggccgtc cccggagccc gaggagccgc ggcccagcgc cgaccccttc      900

ctggagacgc tcacgcgcct ggtgcgcgcg ctgcgggggc ccccgactcc ggcctcgccg      960

ccacgcctgg ccctggaccc gggcgcgctg gccagcttcc cgcagggcct ggtcaacctg     1020

tcggaccccg cggcgctgga gcgcctgctc gacggcgagg agccgctgct gctgctgctg     1080

ccgcccaccg cggccgctgc cggggacccc gcgccattgc cggaccccgc gtcggcgccc     1140

tgggccgcgg gcctggcgcg ccgcgtggcc gccgagctgc aggcggcggc ggccgagctg     1200

cgcagcctcc cggggctgcc ccccgccgca gagccgctgc tggcgcgcct gctcgcactg     1260

tgcccggggg acgccgagga ccagggcggc ccgggcggcc cgctgcgcgc gctgctgctg     1320

ctgaaggcgc tgcaaggcct gcgcgccgag tggcgcgggc gcgagcggag cgggcccggg     1380

cgggcgcagc gcaacgcggg ggccggggcc gccgacgggc cgtgcgcgct gcgcgagctg     1440

cgcgtggact tgcgcgccga gcgctccgtg ctcatccccg agacgtacca ggccaacaac     1500

tgccagggcg cgtgcggctg gccgcagtcg gaccgcaacc cgcgctacgg caaccacgtg     1560

gtgctgctgc taaagatgca ggcccgcggc gccgccctgg cgcgcgcgcc ctgctgcgtg     1620

cccactgcct acgcgggcaa gctgctcatc agcctgtccg aggagcgcat cagcgcgcac     1680

cacgtgccca acatggtggc caccgagtgc ggctgccggt ga                        1722


<210>  29
<211>  1719
<212>  DNA
<213>  Canis lupus familiaris

<400>  29
atgggggctc tggcgctctg gccgctggcc ctggcgctgt cggggatggg gcccctgctg       60

ggagccgagg cccccggagg tgaggtctcg ggcaccccag cctcgcccgg agagccggcc      120

acaggcactg ggggtctcct cttccagcca gactgggact ggccgcctag cgccccacaa      180

gaccccctgt gcctggtgac cctggacaag ggaggcaacg ggagcagccc cccgcttcgg      240

gtggcggggg ccctccgagg ctacgagcac accttcctcg aggccgtgcg gcgagcccgc      300

tggggtcccc acgacctggc caccttcggg gcctgcgccg ccagcgacgg ccggaccacc      360

cagctctccc tgcggcagct gcaagcctgg ctgggggcgc ccggggggcg gcggctggtg      420

gtgctgcacc tggaggaagt gacatgggag ccagcgctgt cgctgaagtt ccaggagccc      480

ccacctggag gagccagtcc cctagagctg gcgctgctgg tgctctaccc tgggccaggc      540

cctgaggtcg ctgtcaccgg ggctggactg ccaggcaccc agaacctttg ccggtcccgg      600

aacacgcgct acctggtgct ggccctggac cacccggtgg gggcctggca cagccctagg      660

gtcaccctga ccgtgcacgc ccgaggagac ggtgccccgc tgagcacccc ccagctgcag      720

gagctgctgt tcgggcccga tgcccgctgc ttcacgcgga tgacgcccgc gctgctcgtg      780

ctgcggctgc ccgggcccac ggcggtgccg gcgcgcggcc tgctggacct cgtgcccttc      840

ccgccgccca ggccctcccg ggagcccgcg gagccccctc ccagcgcaga ccccttcctg      900

gagacgctca cgcgcctggt gcgcgccctg cgcgggccgc cgacccccgc ctcgccgccg      960

cgcctggccc tggaccccgg cgcgctggcg ggcttcccgc agggcctgct caacctgtcg     1020

gaccccgcga cacaggagcg cctgctgggc ggcgaggagc ccctgctgct gctgctgcca     1080

ccccccacgg ccgcggccgg gccccccgcg ccgccgcccc gccccgcgtc cgcgccctgg     1140

gccgcgggcc tcgccctgcg cgtggccgcc gagctgcggg ccgcggccgc cgagctccgc     1200

gggctcccgg ggctgccccc cgccgccgcg ccgctgctgg agcgcctgct cgccctctgc     1260

cccgggggct cggggggctc ggggggctcg ggggacccgc tgcgcgcgct gctgctgctc     1320

aaggcgttgc agggcctgcg cgccgagtgg cgcgggcggg agcggggcgg gcccccccgg     1380

gcgcagcgca gcgcgggggc gggggcggcc gacgggccct gcgcgctgcg cgagctgagc     1440

gtggacctgc gcgccgagcg ctccgtgctc atccccgaga cctaccaggc caacaactgc     1500

cagggcgcgt gcgggtggcc gcagtccgac cgcaacccgc gctacggcaa ccacgtggtg     1560

ctgctgctca agatgcaggc ccgcggcgcc gcgctggctc gcccgccctg ctgcgtgccc     1620

acggcctacg gcggcaagct gctcatcagc ctgtcggagg agcgcatcag cgcgcaccac     1680

gtgcccaaca tggtggccac cgagtgcggc tgccggtga                            1719


<210>  30
<211>  1767
<212>  DNA
<213>  Felis catus

<400>  30
atgcctggtc tgctctctcc gccggccctg gtgctgtcgg tgatgggggc tctgctgatg       60

gccggggacc ctggggaaga ggtctccagc accccggccc tgcctggagg gccagccaca      120

ggcaccgggg gtctcatctt ccacccggat tgggactggc agcccccggg cagtccccaa      180

gaccccctgt gcctggtgac gctggacagg ggtggtaacg ggagcggctc cccgcttcgg      240

gtggtggggg cgctgagagg ctacgagcac gccttcctcg aggctgtgcg gcgggcccgc      300

tggggtcccc acggcctggc caccttcgga gtttgcaccc ccagggacag gcaggccgcc      360

ccgttctctc tgcggcagct gcaggcgtgg ctgggggagc ccggggggcg gcggctggtg      420

gtgctgcacc tggaggaagt gacatgggag ccgacaccct cactgaagtt ccaggagccc      480

ccgcctggag gggccggtcc cctagagctg gcgatgctgg tgctgtaccc tggccctggc      540

cccgaggtca cggtcacagg ggctgggctg ccaggcaccc agagcctctg tcagtcccgg      600

gacacccgct acctggtgct ggcggtggac cacccagaag gggcctggcg cagccccggg      660

ctcaccctga ccctgcaacc ccgcagagac ggtgcgcccc tgagcaccgc ccagctgcag      720

gagctgctgt tcggccccga cccccgctgc ttcacacgca tgaccccggc gctgctcctg      780

ctgccggggc ccgcgcctgc accgctgccc gcgcgtggcc tgctggacca agtgcctctc      840

ccgccgccca ggccctccca ggagcaggcg cccgaggagc cacggtccag cgccgacccc      900

ttcctggaga cgctcacgcg cctggtgcgc gcgctgcggg ggcccccggc ccaggcctcg      960

ccggcgcgcc tggccctgga ccccggcgcg ctggccggct tcccgcaggg cctggtcaac     1020

ctgtcggacc ccgcggcgca ggagcgcctg ctcaacggcg gcgacgagcc gctgctgctg     1080

cttctgctgc cacccgccac gcccaccgcc gccgccgccg ccgccgggga ccccgcgccg     1140

ccgcgcggcc cggcgtccgc gccctgggcc gccggcctag cgcgtcgcgt ggccgccgag     1200

ctgcaggccg cggccgccga gctgcgaggg ctcccggggc tgccgccggc cgccacgccg     1260

ctgctggcgc gcctgctcgc gctgtgcccc ggggattcgg gggactcggg ggacccgggg     1320

gccccccccg gcggcccggg cggcccgctg cgcgcgctgc tgctgctcaa ggcgctgcag     1380

ggtctgcgcg cggagtggcg cgggcgcgag caggccggac cggcgcgggc acagcgcagc     1440

gcgggggccg gggcggccga cgggccgtgc gcgctgcgcg agctgagcgt ggacctgcgc     1500

gccgagcgct ccgtgctcat cccggagacg taccaggcca acaactgcca gggcgcgtgc     1560

ggctggccgc agtccgaccg caacccgcgc tacggcaacc acgtggtgct gctgctcaag     1620

atgcaggccc gcggcgccgc cctggcgcgc ccgccctgct gcgtgcccac ggcctacgcg     1680

ggcaagctcc tcatcagcct gtcggaggag cgcatcagcg cgcaccacgt gcccaacatg     1740

gtggccaccg agtgcggctg ccggtga                                         1767


<210>  31
<211>  573
<212>  PRT
<213>  Equus caballus

<400>  31

Met Arg Ala Pro Ser Leu Ser Trp Leu Ala Leu Val Leu Ser Ala Val 
1               5                   10                  15      


Gly Ala Leu Leu Arg Ala Gly Thr Pro Gly Glu Glu Val Ser Ser Thr 
            20                  25                  30          


Pro Ala Leu Pro Gly Glu Pro Ala Thr Gly Thr Gly Gly Leu Ile Phe 
        35                  40                  45              


His Gln Asp Trp Asp Trp Pro Pro Gly Ser Pro Gln Glu Pro Leu Gly 
    50                  55                  60                  


Cys Leu Val Thr Leu Asp Glu Gly Gly Asn Gln Ser Ser Ala Pro Leu 
65                  70                  75                  80  


Arg Val Ala Gly Ala Leu Ser Gly Tyr Glu Gln Ala Phe Leu Glu Ala 
                85                  90                  95      


Val Gln Arg Thr His Trp Ser Pro Arg Asp Leu Pro Thr Phe Gly Val 
            100                 105                 110         


Cys Ser Pro Ala Asp Arg Gln Ala Ala Val Pro Ser Leu Gln Arg Leu 
        115                 120                 125             


Gln Ala Trp Leu Gly Ala Pro Trp Gly Gln Arg Leu Val Val Leu His 
    130                 135                 140                 


Leu Glu Glu Val Met Trp Glu Pro Thr Pro Ser Leu Arg Phe Gln Glu 
145                 150                 155                 160 


Pro Pro Ser Gly Gly Ala Asn Pro Leu Glu Pro Ala Leu Leu Val Leu 
                165                 170                 175     


Tyr Ala Gly Pro Gly Pro Glu Val Thr Val Thr Gly Ala Gly Leu Pro 
            180                 185                 190         


Gly Ala Gln Ser Leu Cys Pro Ser Pro Asp Thr Arg Tyr Leu Ala Leu 
        195                 200                 205             


Ala Val Asp His Pro Ala Arg Ala Trp Arg His Pro Gly Leu Ile Leu 
    210                 215                 220                 


Thr Leu Gln Pro Arg Gly Asp Gly Ala Pro Leu Ser Thr Ala Gln Leu 
225                 230                 235                 240 


Gln Thr Leu Leu Phe Gly Ala Asp Pro Arg Cys Phe Thr Arg Met Thr 
                245                 250                 255     


Pro Ala Leu Phe Leu Leu Gln Arg Pro Gly Pro Ala Pro Met Pro Ala 
            260                 265                 270         


His Gly Arg Leu Asp Thr Val Pro Phe Pro Pro Ala Arg Pro Ser Pro 
        275                 280                 285             


Glu Pro Glu Glu Pro Arg Pro Ser Ala Asp Pro Phe Leu Glu Thr Leu 
    290                 295                 300                 


Thr Arg Leu Val Arg Ala Leu Arg Gly Pro Pro Thr Pro Ala Ser Pro 
305                 310                 315                 320 


Pro Arg Leu Ala Leu Asp Pro Gly Ala Leu Ala Ser Phe Pro Gln Gly 
                325                 330                 335     


Leu Val Asn Leu Ser Asp Pro Ala Ala Leu Glu Arg Leu Leu Asp Gly 
            340                 345                 350         


Glu Glu Pro Leu Leu Leu Leu Leu Pro Pro Thr Ala Ala Ala Ala Gly 
        355                 360                 365             


Asp Pro Ala Pro Leu Pro Asp Pro Ala Ser Ala Pro Trp Ala Ala Gly 
    370                 375                 380                 


Leu Ala Arg Arg Val Ala Ala Glu Leu Gln Ala Ala Ala Ala Glu Leu 
385                 390                 395                 400 


Arg Ser Leu Pro Gly Leu Pro Pro Ala Ala Glu Pro Leu Leu Ala Arg 
                405                 410                 415     


Leu Leu Ala Leu Cys Pro Gly Asp Ala Glu Asp Gln Gly Gly Pro Gly 
            420                 425                 430         


Gly Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg 
        435                 440                 445             


Ala Glu Trp Arg Gly Arg Glu Arg Ser Gly Pro Gly Arg Ala Gln Arg 
    450                 455                 460                 


Asn Ala Gly Ala Gly Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu 
465                 470                 475                 480 


Arg Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr 
                485                 490                 495     


Gln Ala Asn Asn Cys Gln Gly Ala Cys Gly Trp Pro Gln Ser Asp Arg 
            500                 505                 510         


Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala 
        515                 520                 525             


Arg Gly Ala Ala Leu Ala Arg Ala Pro Cys Cys Val Pro Thr Ala Tyr 
    530                 535                 540                 


Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His 
545                 550                 555                 560 


His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
                565                 570             


<210>  32
<211>  572
<212>  PRT
<213>  Canis lupus familiaris

<400>  32

Met Gly Ala Leu Ala Leu Trp Pro Leu Ala Leu Ala Leu Ser Gly Met 
1               5                   10                  15      


Gly Pro Leu Leu Gly Ala Glu Ala Pro Gly Gly Glu Val Ser Gly Thr 
            20                  25                  30          


Pro Ala Ser Pro Gly Glu Pro Ala Thr Gly Thr Gly Gly Leu Leu Phe 
        35                  40                  45              


Gln Pro Asp Trp Asp Trp Pro Pro Ser Ala Pro Gln Asp Pro Leu Cys 
    50                  55                  60                  


Leu Val Thr Leu Asp Lys Gly Gly Asn Gly Ser Ser Pro Pro Leu Arg 
65                  70                  75                  80  


Val Ala Gly Ala Leu Arg Gly Tyr Glu His Thr Phe Leu Glu Ala Val 
                85                  90                  95      


Arg Arg Ala Arg Trp Gly Pro His Asp Leu Ala Thr Phe Gly Ala Cys 
            100                 105                 110         


Ala Ala Ser Asp Gly Arg Thr Thr Gln Leu Ser Leu Arg Gln Leu Gln 
        115                 120                 125             


Ala Trp Leu Gly Ala Pro Gly Gly Arg Arg Leu Val Val Leu His Leu 
    130                 135                 140                 


Glu Glu Val Thr Trp Glu Pro Ala Leu Ser Leu Lys Phe Gln Glu Pro 
145                 150                 155                 160 


Pro Pro Gly Gly Ala Ser Pro Leu Glu Leu Ala Leu Leu Val Leu Tyr 
                165                 170                 175     


Pro Gly Pro Gly Pro Glu Val Ala Val Thr Gly Ala Gly Leu Pro Gly 
            180                 185                 190         


Thr Gln Asn Leu Cys Arg Ser Arg Asn Thr Arg Tyr Leu Val Leu Ala 
        195                 200                 205             


Leu Asp His Pro Val Gly Ala Trp His Ser Pro Arg Val Thr Leu Thr 
    210                 215                 220                 


Val His Ala Arg Gly Asp Gly Ala Pro Leu Ser Thr Pro Gln Leu Gln 
225                 230                 235                 240 


Glu Leu Leu Phe Gly Pro Asp Ala Arg Cys Phe Thr Arg Met Thr Pro 
                245                 250                 255     


Ala Leu Leu Val Leu Arg Leu Pro Gly Pro Thr Ala Val Pro Ala Arg 
            260                 265                 270         


Gly Leu Leu Asp Leu Val Pro Phe Pro Pro Pro Arg Pro Ser Arg Glu 
        275                 280                 285             


Pro Ala Glu Pro Pro Pro Ser Ala Asp Pro Phe Leu Glu Thr Leu Thr 
    290                 295                 300                 


Arg Leu Val Arg Ala Leu Arg Gly Pro Pro Thr Pro Ala Ser Pro Pro 
305                 310                 315                 320 


Arg Leu Ala Leu Asp Pro Gly Ala Leu Ala Gly Phe Pro Gln Gly Leu 
                325                 330                 335     


Leu Asn Leu Ser Asp Pro Ala Thr Gln Glu Arg Leu Leu Gly Gly Glu 
            340                 345                 350         


Glu Pro Leu Leu Leu Leu Leu Pro Pro Pro Thr Ala Ala Ala Gly Pro 
        355                 360                 365             


Pro Ala Pro Pro Pro Arg Pro Ala Ser Ala Pro Trp Ala Ala Gly Leu 
    370                 375                 380                 


Ala Leu Arg Val Ala Ala Glu Leu Arg Ala Ala Ala Ala Glu Leu Arg 
385                 390                 395                 400 


Gly Leu Pro Gly Leu Pro Pro Ala Ala Ala Pro Leu Leu Glu Arg Leu 
                405                 410                 415     


Leu Ala Leu Cys Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Asp 
            420                 425                 430         


Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg Ala 
        435                 440                 445             


Glu Trp Arg Gly Arg Glu Arg Gly Gly Pro Pro Arg Ala Gln Arg Ser 
    450                 455                 460                 


Ala Gly Ala Gly Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser 
465                 470                 475                 480 


Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln 
                485                 490                 495     


Ala Asn Asn Cys Gln Gly Ala Cys Gly Trp Pro Gln Ser Asp Arg Asn 
            500                 505                 510         


Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala Arg 
        515                 520                 525             


Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr Gly 
    530                 535                 540                 


Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His His 
545                 550                 555                 560 


Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
                565                 570         


<210>  33
<211>  588
<212>  PRT
<213>  Felis catus

<400>  33

Met Pro Gly Leu Leu Ser Pro Pro Ala Leu Val Leu Ser Val Met Gly 
1               5                   10                  15      


Ala Leu Leu Met Ala Gly Asp Pro Gly Glu Glu Val Ser Ser Thr Pro 
            20                  25                  30          


Ala Leu Pro Gly Gly Pro Ala Thr Gly Thr Gly Gly Leu Ile Phe His 
        35                  40                  45              


Pro Asp Trp Asp Trp Gln Pro Pro Gly Ser Pro Gln Asp Pro Leu Cys 
    50                  55                  60                  


Leu Val Thr Leu Asp Arg Gly Gly Asn Gly Ser Gly Ser Pro Leu Arg 
65                  70                  75                  80  


Val Val Gly Ala Leu Arg Gly Tyr Glu His Ala Phe Leu Glu Ala Val 
                85                  90                  95      


Arg Arg Ala Arg Trp Gly Pro His Gly Leu Ala Thr Phe Gly Val Cys 
            100                 105                 110         


Thr Pro Arg Asp Arg Gln Ala Ala Pro Phe Ser Leu Arg Gln Leu Gln 
        115                 120                 125             


Ala Trp Leu Gly Glu Pro Gly Gly Arg Arg Leu Val Val Leu His Leu 
    130                 135                 140                 


Glu Glu Val Thr Trp Glu Pro Thr Pro Ser Leu Lys Phe Gln Glu Pro 
145                 150                 155                 160 


Pro Pro Gly Gly Ala Gly Pro Leu Glu Leu Ala Met Leu Val Leu Tyr 
                165                 170                 175     


Pro Gly Pro Gly Pro Glu Val Thr Val Thr Gly Ala Gly Leu Pro Gly 
            180                 185                 190         


Thr Gln Ser Leu Cys Gln Ser Arg Asp Thr Arg Tyr Leu Val Leu Ala 
        195                 200                 205             


Val Asp His Pro Glu Gly Ala Trp Arg Ser Pro Gly Leu Thr Leu Thr 
    210                 215                 220                 


Leu Gln Pro Arg Arg Asp Gly Ala Pro Leu Ser Thr Ala Gln Leu Gln 
225                 230                 235                 240 


Glu Leu Leu Phe Gly Pro Asp Pro Arg Cys Phe Thr Arg Met Thr Pro 
                245                 250                 255     


Ala Leu Leu Leu Leu Pro Gly Pro Ala Pro Ala Pro Leu Pro Ala Arg 
            260                 265                 270         


Gly Leu Leu Asp Gln Val Pro Leu Pro Pro Pro Arg Pro Ser Gln Glu 
        275                 280                 285             


Gln Ala Pro Glu Glu Pro Arg Ser Ser Ala Asp Pro Phe Leu Glu Thr 
    290                 295                 300                 


Leu Thr Arg Leu Val Arg Ala Leu Arg Gly Pro Pro Ala Gln Ala Ser 
305                 310                 315                 320 


Pro Ala Arg Leu Ala Leu Asp Pro Gly Ala Leu Ala Gly Phe Pro Gln 
                325                 330                 335     


Gly Leu Val Asn Leu Ser Asp Pro Ala Ala Gln Glu Arg Leu Leu Asn 
            340                 345                 350         


Gly Gly Asp Glu Pro Leu Leu Leu Leu Leu Leu Pro Pro Ala Thr Pro 
        355                 360                 365             


Thr Ala Ala Ala Ala Ala Ala Gly Asp Pro Ala Pro Pro Arg Gly Pro 
    370                 375                 380                 


Ala Ser Ala Pro Trp Ala Ala Gly Leu Ala Arg Arg Val Ala Ala Glu 
385                 390                 395                 400 


Leu Gln Ala Ala Ala Ala Glu Leu Arg Gly Leu Pro Gly Leu Pro Pro 
                405                 410                 415     


Ala Ala Thr Pro Leu Leu Ala Arg Leu Leu Ala Leu Cys Pro Gly Asp 
            420                 425                 430         


Ser Gly Asp Ser Gly Asp Pro Gly Ala Pro Pro Gly Gly Pro Gly Gly 
        435                 440                 445             


Pro Leu Arg Ala Leu Leu Leu Leu Lys Ala Leu Gln Gly Leu Arg Ala 
    450                 455                 460                 


Glu Trp Arg Gly Arg Glu Gln Ala Gly Pro Ala Arg Ala Gln Arg Ser 
465                 470                 475                 480 


Ala Gly Ala Gly Ala Ala Asp Gly Pro Cys Ala Leu Arg Glu Leu Ser 
                485                 490                 495     


Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile Pro Glu Thr Tyr Gln 
            500                 505                 510         


Ala Asn Asn Cys Gln Gly Ala Cys Gly Trp Pro Gln Ser Asp Arg Asn 
        515                 520                 525             


Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu Lys Met Gln Ala Arg 
    530                 535                 540                 


Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val Pro Thr Ala Tyr Ala 
545                 550                 555                 560 


Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg Ile Ser Ala His His 
                565                 570                 575     


Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys Arg 
            580                 585             


<210>  34
<211>  1683
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Thr Gly Cys Gly Gly Gly Ala Cys Cys Thr Gly Cys Cys Thr Cys 
1               5                   10                  15      


Thr Cys Ala Cys Cys Ala Gly Cys Cys Thr Gly Gly Cys Cys Cys Thr 
            20                  25                  30          


Ala Gly Thr Gly Cys Thr Gly Thr Cys Thr Gly Cys Cys Cys Thr Gly 
        35                  40                  45              


Gly Gly Gly Gly Cys Thr Cys Thr Gly Cys Thr Gly Gly Gly Gly Ala 
    50                  55                  60                  


Cys Thr Gly Ala Gly Gly Cys Cys Cys Thr Cys Ala Gly Ala Gly Cys 
65                  70                  75                  80  


Ala Gly Ala Gly Gly Ala Gly Cys Cys Ala Gly Cys Thr Gly Thr Gly 
                85                  90                  95      


Gly Gly Cys Ala Cys Cys Ala Gly Thr Gly Gly Cys Cys Thr Cys Ala 
            100                 105                 110         


Thr Cys Thr Thr Cys Cys Gly Ala Gly Ala Ala Gly Ala Cys Thr Thr 
        115                 120                 125             


Gly Gly Ala Cys Thr Gly Gly Cys Cys Thr Cys Cys Ala Gly Gly Cys 
    130                 135                 140                 


Ala Gly Cys Cys Cys Ala Cys Ala Ala Gly Ala Gly Cys Cys Thr Cys 
145                 150                 155                 160 


Thr Gly Thr Gly Cys Cys Thr Gly Gly Thr Gly Gly Cys Ala Cys Thr 
                165                 170                 175     


Gly Gly Gly Cys Gly Gly Gly Gly Ala Cys Ala Gly Cys Ala Ala Thr 
            180                 185                 190         


Gly Gly Cys Ala Gly Cys Ala Gly Cys Thr Cys Cys Cys Cys Cys Cys 
        195                 200                 205             


Thr Gly Cys Gly Gly Gly Thr Gly Gly Thr Gly Gly Gly Gly Gly Cys 
    210                 215                 220                 


Thr Cys Thr Ala Ala Gly Cys Gly Cys Cys Thr Ala Thr Gly Ala Gly 
225                 230                 235                 240 


Cys Ala Gly Gly Cys Cys Thr Thr Cys Cys Thr Gly Gly Gly Gly Gly 
                245                 250                 255     


Cys Cys Gly Thr Gly Cys Ala Gly Ala Gly Gly Gly Cys Cys Cys Gly 
            260                 265                 270         


Cys Thr Gly Gly Gly Gly Cys Cys Cys Cys Cys Gly Ala Gly Ala Cys 
        275                 280                 285             


Cys Thr Gly Gly Cys Cys Ala Cys Cys Thr Thr Cys Gly Gly Gly Gly 
    290                 295                 300                 


Thr Cys Thr Gly Cys Ala Ala Cys Ala Cys Cys Gly Gly Thr Gly Ala 
305                 310                 315                 320 


Cys Ala Gly Gly Cys Ala Gly Gly Cys Thr Gly Cys Cys Thr Thr Gly 
                325                 330                 335     


Cys Cys Cys Thr Cys Thr Cys Thr Ala Cys Gly Gly Cys Gly Gly Cys 
            340                 345                 350         


Thr Gly Gly Gly Gly Gly Cys Cys Thr Gly Gly Cys Thr Gly Cys Gly 
        355                 360                 365             


Gly Gly Ala Cys Cys Cys Thr Gly Gly Gly Gly Gly Gly Cys Ala Gly 
    370                 375                 380                 


Cys Gly Cys Cys Thr Gly Gly Thr Gly Gly Thr Cys Cys Thr Ala Cys 
385                 390                 395                 400 


Ala Cys Cys Thr Gly Gly Ala Gly Gly Ala Ala Gly Thr Gly Ala Cys 
                405                 410                 415     


Cys Thr Gly Gly Gly Ala Gly Cys Cys Ala Ala Cys Ala Cys Cys Cys 
            420                 425                 430         


Thr Cys Gly Cys Thr Gly Ala Gly Gly Thr Thr Cys Cys Ala Gly Gly 
        435                 440                 445             


Ala Gly Cys Cys Cys Cys Cys Gly Cys Cys Thr Gly Gly Ala Gly Gly 
    450                 455                 460                 


Ala Gly Cys Thr Gly Gly Cys Cys Cys Cys Cys Cys Ala Gly Ala Gly 
465                 470                 475                 480 


Cys Thr Gly Gly Cys Gly Cys Thr Gly Cys Thr Gly Gly Thr Gly Cys 
                485                 490                 495     


Thr Gly Thr Ala Cys Cys Cys Thr Gly Gly Gly Cys Cys Thr Gly Gly 
            500                 505                 510         


Cys Cys Cys Thr Gly Ala Gly Gly Thr Cys Ala Cys Thr Gly Thr Gly 
        515                 520                 525             


Ala Cys Gly Ala Gly Gly Gly Cys Thr Gly Gly Gly Cys Thr Gly Cys 
    530                 535                 540                 


Cys Gly Gly Gly Thr Gly Cys Cys Cys Ala Gly Ala Gly Cys Cys Thr 
545                 550                 555                 560 


Cys Thr Gly Cys Cys Cys Cys Thr Cys Cys Cys Gly Ala Gly Ala Cys 
                565                 570                 575     


Ala Cys Cys Cys Gly Cys Thr Ala Cys Cys Thr Gly Gly Thr Gly Thr 
            580                 585                 590         


Thr Ala Gly Cys Gly Gly Thr Gly Gly Ala Cys Cys Gly Cys Cys Cys 
        595                 600                 605             


Thr Gly Cys Gly Gly Gly Gly Gly Cys Cys Thr Gly Gly Cys Gly Cys 
    610                 615                 620                 


Gly Gly Cys Thr Cys Cys Gly Gly Gly Cys Thr Gly Gly Cys Cys Thr 
625                 630                 635                 640 


Thr Gly Ala Cys Cys Cys Thr Gly Cys Ala Gly Cys Cys Cys Cys Gly 
                645                 650                 655     


Cys Gly Gly Ala Gly Ala Gly Gly Ala Cys Thr Cys Cys Cys Gly Gly 
            660                 665                 670         


Cys Thr Gly Ala Gly Thr Ala Cys Cys Gly Cys Cys Cys Gly Gly Cys 
        675                 680                 685             


Thr Gly Cys Ala Gly Gly Cys Ala Cys Thr Gly Cys Thr Gly Thr Thr 
    690                 695                 700                 


Cys Gly Gly Cys Gly Ala Cys Gly Ala Cys Cys Ala Cys Cys Gly Cys 
705                 710                 715                 720 


Thr Gly Cys Thr Thr Cys Ala Cys Ala Cys Gly Gly Ala Thr Gly Ala 
                725                 730                 735     


Cys Cys Cys Cys Gly Gly Cys Cys Cys Thr Gly Cys Thr Cys Cys Thr 
            740                 745                 750         


Gly Cys Thr Gly Cys Cys Gly Cys Gly Gly Thr Cys Cys Gly Ala Gly 
        755                 760                 765             


Cys Cys Cys Gly Cys Gly Cys Cys Gly Cys Thr Gly Cys Cys Thr Gly 
    770                 775                 780                 


Cys Gly Cys Ala Cys Gly Gly Cys Cys Ala Gly Cys Thr Gly Gly Ala 
785                 790                 795                 800 


Cys Ala Cys Cys Gly Thr Gly Cys Cys Cys Thr Thr Cys Cys Cys Gly 
                805                 810                 815     


Cys Cys Gly Cys Cys Cys Ala Gly Gly Cys Cys Ala Thr Cys Cys Gly 
            820                 825                 830         


Cys Gly Gly Ala Ala Cys Thr Cys Gly Ala Gly Gly Ala Gly Thr Cys 
        835                 840                 845             


Gly Cys Cys Ala Cys Cys Cys Ala Gly Cys Gly Cys Ala Gly Ala Cys 
    850                 855                 860                 


Cys Cys Cys Thr Thr Cys Cys Thr Gly Gly Ala Gly Ala Cys Gly Cys 
865                 870                 875                 880 


Thr Cys Ala Cys Gly Cys Gly Cys Cys Thr Gly Gly Thr Gly Cys Gly 
                885                 890                 895     


Gly Gly Cys Gly Cys Thr Gly Cys Gly Gly Gly Thr Cys Cys Cys Cys 
            900                 905                 910         


Cys Cys Gly Gly Cys Cys Cys Gly Gly Gly Cys Cys Thr Cys Cys Gly 
        915                 920                 925             


Cys Gly Cys Cys Gly Cys Gly Cys Cys Thr Gly Gly Cys Cys Cys Thr 
    930                 935                 940                 


Gly Gly Ala Thr Cys Cys Gly Gly Ala Cys Gly Cys Gly Cys Thr Gly 
945                 950                 955                 960 


Gly Cys Cys Gly Gly Cys Thr Thr Cys Cys Cys Gly Cys Ala Gly Gly 
                965                 970                 975     


Gly Cys Cys Thr Ala Gly Thr Cys Ala Ala Cys Cys Thr Gly Thr Cys 
            980                 985                 990         


Gly Gly Ala Cys Cys Cys Cys Gly  Cys Gly Gly Cys Gly  Cys Thr Gly 
        995                 1000                 1005             


Gly Ala  Gly Cys Gly Cys Cys  Thr Ala Cys Thr Cys  Gly Ala Cys 
    1010                 1015                 1020             


Gly Gly  Cys Gly Ala Gly Gly  Ala Gly Cys Cys Gly  Cys Thr Gly 
    1025                 1030                 1035             


Cys Thr  Gly Cys Thr Gly Cys  Thr Gly Cys Thr Gly  Ala Gly Gly 
    1040                 1045                 1050             


Cys Cys  Cys Ala Cys Thr Gly  Cys Gly Gly Cys Cys  Ala Cys Cys 
    1055                 1060                 1065             


Ala Cys  Cys Gly Gly Gly Gly  Ala Thr Cys Cys Thr  Gly Cys Gly 
    1070                 1075                 1080             


Cys Cys  Cys Cys Thr Gly Cys  Ala Cys Gly Ala Cys  Cys Cys Cys 
    1085                 1090                 1095             


Ala Cys  Gly Thr Cys Gly Gly  Cys Gly Cys Cys Gly  Thr Gly Gly 
    1100                 1105                 1110             


Gly Cys  Cys Ala Cys Gly Gly  Cys Cys Cys Thr Gly  Gly Cys Gly 
    1115                 1120                 1125             


Cys Gly  Cys Cys Gly Cys Gly  Thr Gly Gly Cys Thr  Gly Cys Thr 
    1130                 1135                 1140             


Gly Ala  Ala Cys Thr Gly Cys  Ala Ala Gly Cys Gly  Gly Cys Gly 
    1145                 1150                 1155             


Gly Cys  Thr Gly Cys Cys Gly  Ala Gly Cys Thr Gly  Cys Gly Ala 
    1160                 1165                 1170             


Ala Gly  Cys Cys Thr Cys Cys  Cys Gly Gly Gly Thr  Cys Thr Gly 
    1175                 1180                 1185             


Cys Cys  Thr Cys Cys Gly Gly  Cys Cys Ala Cys Ala  Gly Cys Cys 
    1190                 1195                 1200             


Cys Cys  Gly Cys Thr Gly Cys  Thr Gly Gly Cys Gly  Cys Gly Cys 
    1205                 1210                 1215             


Cys Thr  Gly Cys Thr Cys Gly  Cys Gly Cys Thr Cys  Thr Gly Cys 
    1220                 1225                 1230             


Cys Cys  Ala Gly Gly Thr Gly  Gly Cys Cys Cys Cys  Gly Gly Cys 
    1235                 1240                 1245             


Gly Gly  Cys Cys Thr Cys Gly  Gly Cys Gly Ala Thr  Cys Cys Cys 
    1250                 1255                 1260             


Cys Thr  Gly Cys Gly Ala Gly  Cys Gly Cys Thr Gly  Cys Thr Gly 
    1265                 1270                 1275             


Cys Thr  Cys Cys Thr Gly Ala  Ala Gly Gly Cys Gly  Cys Thr Gly 
    1280                 1285                 1290             


Cys Ala  Gly Gly Gly Cys Cys  Thr Gly Cys Gly Cys  Gly Thr Gly 
    1295                 1300                 1305             


Gly Ala  Gly Thr Gly Gly Cys  Gly Cys Gly Gly Gly  Cys Gly Gly 
    1310                 1315                 1320             


Gly Ala  Thr Cys Cys Gly Cys  Gly Cys Gly Gly Gly  Cys Cys Gly 
    1325                 1330                 1335             


Gly Gly  Thr Cys Gly Gly Gly  Cys Ala Cys Ala Gly  Cys Gly Cys 
    1340                 1345                 1350             


Ala Gly  Cys Gly Cys Gly Gly  Gly Gly Gly Cys Cys  Ala Cys Cys 
    1355                 1360                 1365             


Gly Cys  Cys Gly Cys Cys Gly  Ala Cys Gly Gly Gly  Cys Cys Gly 
    1370                 1375                 1380             


Thr Gly  Cys Gly Cys Gly Cys  Thr Gly Cys Gly Cys  Gly Ala Gly 
    1385                 1390                 1395             


Cys Thr  Cys Ala Gly Cys Gly  Thr Ala Gly Ala Cys  Cys Thr Cys 
    1400                 1405                 1410             


Cys Gly  Cys Gly Cys Cys Gly  Ala Gly Cys Gly Cys  Thr Cys Cys 
    1415                 1420                 1425             


Gly Thr  Ala Cys Thr Cys Ala  Thr Cys Cys Cys Cys  Gly Ala Gly 
    1430                 1435                 1440             


Ala Cys  Cys Thr Ala Cys Cys  Ala Gly Gly Cys Cys  Ala Ala Cys 
    1445                 1450                 1455             


Ala Ala  Thr Thr Gly Cys Cys  Ala Gly Gly Gly Cys  Gly Thr Gly 
    1460                 1465                 1470             


Thr Gly  Cys Gly Gly Cys Thr  Gly Gly Cys Cys Thr  Cys Ala Gly 
    1475                 1480                 1485             


Thr Cys  Cys Gly Ala Cys Cys  Gly Cys Ala Ala Cys  Cys Cys Gly 
    1490                 1495                 1500             


Cys Gly  Cys Thr Ala Cys Gly  Gly Cys Ala Ala Cys  Cys Ala Cys 
    1505                 1510                 1515             


Gly Thr  Gly Gly Thr Gly Cys  Thr Gly Cys Thr Gly  Cys Thr Gly 
    1520                 1525                 1530             


Ala Ala  Gly Ala Thr Gly Cys  Ala Gly Gly Thr Cys  Cys Gly Thr 
    1535                 1540                 1545             


Gly Gly  Gly Gly Cys Cys Gly  Cys Cys Cys Thr Gly  Gly Cys Gly 
    1550                 1555                 1560             


Cys Gly  Cys Cys Cys Ala Cys  Cys Cys Thr Gly Cys  Thr Gly Cys 
    1565                 1570                 1575             


Gly Thr  Gly Cys Cys Cys Ala  Cys Cys Gly Cys Cys  Thr Ala Cys 
    1580                 1585                 1590             


Gly Cys  Gly Gly Gly Cys Ala  Ala Gly Cys Thr Gly  Cys Thr Cys 
    1595                 1600                 1605             


Ala Thr  Cys Ala Gly Cys Cys  Thr Gly Thr Cys Gly  Gly Ala Gly 
    1610                 1615                 1620             


Gly Ala  Gly Cys Gly Cys Ala  Thr Cys Ala Gly Cys  Gly Cys Gly 
    1625                 1630                 1635             


Cys Ala  Cys Cys Ala Cys Gly  Thr Gly Cys Cys Cys  Ala Ala Cys 
    1640                 1645                 1650             


Ala Thr  Gly Gly Thr Gly Gly  Cys Cys Ala Cys Cys  Gly Ala Gly 
    1655                 1660                 1665             


Thr Gly  Thr Gly Gly Cys Thr  Gly Cys Cys Gly Gly  Thr Gly Ala 
    1670                 1675                 1680             


<210>  35
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mature processed AMH

<400>  35
agcgcggggg ccaccgccgc cgacgggccg tgcgcgctgc gcgagctcag cgtagacctc       60

cgcgccgagc gctccgtact catccccgag acctaccagg ccaacaattg ccagggcgtg      120

tgcggctggc ctcagtccga ccgcaacccg cgctacggca accacgtggt gctgctgctg      180

aagatgcagg tccgtggggc cgccctggcg cgcccaccct gctgcgtgcc caccgcctac      240

gcgggcaagc tgctcatcag cctgtcggag gagcgcatca gcgcgcacca cgtgcccaac      300

atggtggcca ccgagtgtgg ctgccggtga                                       330


<210>  36
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature processed AMH

<400>  36

Ser Val Ser Ser Ser Ala Gly Ala Thr Ala Ala Asp Gly Pro Cys Ala 
1               5                   10                  15      


Leu Arg Glu Leu Ser Val Asp Leu Arg Ala Glu Arg Ser Val Leu Ile 
            20                  25                  30          


Pro Glu Thr Tyr Gln Ala Asn Asn Cys Gln Gly Val Cys Gly Trp Pro 
        35                  40                  45              


Gln Ser Asp Arg Asn Pro Arg Tyr Gly Asn His Val Val Leu Leu Leu 
    50                  55                  60                  


Lys Met Gln Ala Arg Gly Ala Ala Leu Ala Arg Pro Pro Cys Cys Val 
65                  70                  75                  80  


Pro Thr Ala Tyr Ala Gly Lys Leu Leu Ile Ser Leu Ser Glu Glu Arg 
                85                  90                  95      


Ile Ser Ala His His Val Pro Asn Met Val Ala Thr Glu Cys Gly Cys 
            100                 105                 110         


Arg 
    


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site


<220>
<221>  X
<222>  (1)..(1)
<223>  X is absent or isoleucine

<220>
<221>  X
<222>  (2)..(2)
<223>  X is absent or serine

<220>
<221>  X
<222>  (3)..(3)
<223>  X is absent or serine

<220>
<221>  X
<222>  (8)..(8)
<223>  X is absent or serine

<220>
<221>  X
<222>  (9)..(9)
<223>  X is absent or isoleucine

<220>
<221>  X
<222>  (10)..(10)
<223>  X is absent or serine

<220>
<221>  X
<222>  (11)..(11)
<223>  X is absent or serine

<400>  37

Xaa Xaa Xaa Arg Lys Lys Arg Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  38

Arg Lys Lys Arg 
1               


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  39

Ile Ser Ser Arg Lys Lys Arg 
1               5           


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  40

Arg Lys Lys Arg Ser Val Ser Ser 
1               5               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal extension

<400>  41

Ser Val Ser Ser 
1               


