                         SEQUENCE LISTING

<110>  Monash University
 
<120>  Antibodies for binding plasmin

<130>  53096343AZD

<150>  AU2019904049
<151>  2019-10-28

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LCDR1 (protein)

<400>  1

Asp Ser Gly Ser 
1               


<210>  2
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LCDR2 (protein)

<400>  2

Gly Ser Asp 
1           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LCDR3 (protein)

<400>  3

Gly Thr Ala Asp Ser Ser Thr Thr Ala 
1               5                   


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HCDR1 (protein)

<400>  4

Gly Phe Ile Phe Ser Asp Tyr Gly 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HCDR2 (protein)

<400>  5

Ile Asp Asp Asp Gly Gly Gly Thr 
1               5               


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HCDR3 (protein)

<400>  6

Ala Lys Ala Val Gly Tyr Gly Cys Thr Tyr Leu Gly Tyr Ser Cys Ala 
1               5                   10                  15      


Gly Ser Ile Asp Ala 
            20      


<210>  7
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, VL (protein)

<400>  7

Gln Ala Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Thr Cys Ser Gly Gly Asp Ser Gly Ser Tyr Gly Trp 
            20                  25                  30          


Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Val Ile Tyr Gly 
        35                  40                  45              


Ser Asp Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Thr 
    50                  55                  60                  


Ser Gly Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp 
65                  70                  75                  80  


Glu Ala Ile Tyr Tyr Cys Gly Thr Ala Asp Ser Ser Thr Thr Ala Ala 
                85                  90                  95      


Gly Thr Thr Leu Thr Val Leu 
            100             


<210>  8
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, VH (protein)

<400>  8

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Gly Ser Gly Phe Ile Phe Ser Asp Tyr 
            20                  25                  30          


Gly Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asp Asp Asp Gly Gly Gly Thr Ser Tyr Tyr Ala Pro Ala 
    50                  55                  60                  


Val Lys Gly Arg Ala Thr Ile Ser Arg Asp Asn Gly Gln Ser Thr Val 
65                  70                  75                  80  


Arg Leu Gln Leu Asn Asn Leu Arg Ala Glu Asp Thr Gly Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Ala Val Gly Tyr Gly Cys Thr Tyr Leu Gly Tyr Ser Cys 
            100                 105                 110         


Ala Gly Ser Ile Asp Ala Trp Gly His Gly Thr Glu Val Ile Val Ser 
        115                 120                 125             


Ser 
    


<210>  9
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LCDR1 (DNA)

<400>  9
gatagcggct cc                                                           12


<210>  10
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LCDR2 (DNA)

<400>  10
ggctctgat                                                                9


<210>  11
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LCDR3 (DNA)

<400>  11
ggcaccgccg actctagcac cacagccg                                          28


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HCDR1 (DNA)

<400>  12
ggcttcatct tttctgacta cgga                                              24


<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HCDR2 (DNA)

<400>  13
atcgacgatg acggaggagg cacctcc                                           27


<210>  14
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HCDR3 (DNA)

<400>  14
gccaaggccg tgggctatgg ctgcacatac ctgggctatt cttgtgcagg cagcatcgac       60

gca                                                                     63


<210>  15
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, VL (DNA)

<400>  15
caggccgcac tgacccagcc tagctccgtg agcgccaacc caggcgagac agtgaagatc       60

acatgctccg gaggcgatag cggctcctac ggctggtatc agcagaaggc ccccggctcc      120

gcccctgtga ccgtgatcta cggctctgat aagcggccaa gcgacatccc ctcccgcttc      180

tctggcagca catccggctc taccaataca ctgaccatca caggcgtgca ggtggaggat      240

gaggccatct actattgcgg caccgccgac tctagcacca cagccgccgg caccacactg      300

acagtgctg                                                              309


<210>  16
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, VH (DNA)

<400>  16
gccgtgaccc tggatgagag cggaggaggc ctccagacac ccggcggcgc cctgagcctg       60

gtgtgcaagg gctccggctt catcttttct gactacggaa tgttttgggt gcgccaggcc      120

cccggcaagg gcctggagtg ggtggcagga atcgacgatg acggaggagg cacctcctac      180

tatgcacctg ccgtgaaggg aagggcaacc atcagcagag ataacggcca gagcaccgtg      240

aggctccagc tgaacaatct gagagccgag gacaccggca catactattg tgccaaggcc      300

gtgggctatg gctgcacata cctgggctat tcttgtgcag gcagcatcga cgcatggggc      360

cacggcaccg aagtgatcgt gagcagc                                          387


<210>  17
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LFR1 (protein)

<400>  17

Gln Ala Ala Leu Thr Gln Pro Ser Ser Val Ser Ala Asn Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Thr Cys Ser Gly Gly 
            20                  25  


<210>  18
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LFR2 (protein)

<400>  18

Tyr Gly Trp Tyr Gln Gln Lys Ala Pro Gly Ser Ala Pro Val Thr Val 
1               5                   10                  15      


Ile Tyr 
        


<210>  19
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LFR3 (protein)

<400>  19

Lys Arg Pro Ser Asp Ile Pro Ser Arg Phe Ser Gly Ser Thr Ser Gly 
1               5                   10                  15      


Ser Thr Asn Thr Leu Thr Ile Thr Gly Val Gln Val Glu Asp Glu Ala 
            20                  25                  30          


Ile Tyr Tyr Cys 
        35      


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LFR4 (protein)

<400>  20

Ala Gly Thr Thr Leu Thr Val Leu 
1               5               


<210>  21
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HFR1 (protein)

<400>  21

Ala Val Thr Leu Asp Glu Ser Gly Gly Gly Leu Gln Thr Pro Gly Gly 
1               5                   10                  15      


Ala Leu Ser Leu Val Cys Lys Gly Ser 
            20                  25  


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HFR2 (protein)

<400>  22

Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HFR3 (protein)

<400>  23

Ser Tyr Tyr Ala Pro Ala Val Lys Gly Arg Ala Thr Ile Ser Arg Asp 
1               5                   10                  15      


Asn Gly Gln Ser Thr Val Arg Leu Gln Leu Asn Asn Leu Arg Ala Glu 
            20                  25                  30          


Asp Thr Gly Thr Tyr Tyr Cys 
        35                  


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HFR4 (protein)

<400>  24

Trp Gly His Gly Thr Glu Val Ile Val Ser Ser 
1               5                   10      


<210>  25
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LFR1 (DNA)

<400>  25
caggccgcac tgacccagcc tagctccgtg agcgccaacc caggcgagac agtgaagatc       60

acatgctccg gaggc                                                        75


<210>  26
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LFR2 (DNA)

<400>  26
tacggctggt atcagcagaa ggcccccggc tccgcccctg tgaccgtgat ctac             54


<210>  27
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LFR3 (DNA)

<400>  27
aagcggccaa gcgacatccc ctcccgcttc tctggcagca catccggctc taccaataca       60

ctgaccatca caggcgtgca ggtggaggat gaggccatct actattgc                   108


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, LFR4 (DNA)

<400>  28
gccggcacca cactgacagt gctg                                              24


<210>  29
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HFR1 (DNA)

<400>  29
gccgtgaccc tggatgagag cggaggaggc ctccagacac ccggcggcgc cctgagcctg       60

gtgtgcaagg gctcc                                                        75


<210>  30
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HFR2 (DNA)

<400>  30
atgttttggg tgcgccaggc ccccggcaag ggcctggagt gggtggcagg a                51


<210>  31
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HFR3 (DNA)

<400>  31
tcctactatg cacctgccgt gaagggaagg gcaaccatca gcagagataa cggccagagc       60

accgtgaggc tccagctgaa caatctgaga gccgaggaca ccggcacata ctattgt         117


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody B10, HFR4 (DNA)

<400>  32
tggggccacg gcaccgaagt gatcgtgagc agc                                    33


<210>  33
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser Leu Phe Ser 
1               5                   10                  15      


Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu Cys Ala Ala 
            20                  25                  30          


Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe Gln Tyr His 
        35                  40                  45              


Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg Lys Ser Ser 
    50                  55                  60                  


Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys Lys Val Tyr 
65                  70                  75                  80  


Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg Gly Thr Met 
                85                  90                  95      


Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser Ser Thr Ser 
            100                 105                 110         


Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser Glu Gly Leu 
        115                 120                 125             


Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln Gly Pro Trp 
    130                 135                 140                 


Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys Asp Ile Leu 
145                 150                 155                 160 


Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn Tyr Asp Gly 
                165                 170                 175     


Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala Trp Asp Ser 
            180                 185                 190         


Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe Pro Asn Lys 
        195                 200                 205             


Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu Leu Arg Pro 
    210                 215                 220                 


Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu Cys Asp Ile 
225                 230                 235                 240 


Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr Tyr Gln Cys 
                245                 250                 255     


Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala Val Thr Val 
            260                 265                 270         


Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro His Thr His 
        275                 280                 285             


Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp Glu Asn Tyr 
    290                 295                 300                 


Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His Thr Thr Asn 
305                 310                 315                 320 


Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys Asp Ser Ser 
                325                 330                 335     


Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro Glu Leu Thr 
            340                 345                 350         


Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser Tyr Arg Gly 
        355                 360                 365             


Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser Trp Ser Ser 
    370                 375                 380                 


Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr Pro Asn Ala 
385                 390                 395                 400 


Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp Lys Gly Pro 
                405                 410                 415     


Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu 
            420                 425                 430         


Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro Pro Pro Val 
        435                 440                 445             


Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp Cys Met Phe 
    450                 455                 460                 


Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr Val Thr Gly 
465                 470                 475                 480 


Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg His Ser Ile 
                485                 490                 495     


Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn Tyr Cys 
            500                 505                 510         


Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr Thr Thr Asn 
        515                 520                 525             


Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys Ala Ala Pro 
    530                 535                 540                 


Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys Pro Gly 
545                 550                 555                 560 


Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro Trp Gln 
                565                 570                 575     


Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly Thr Leu 
            580                 585                 590         


Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu Lys Ser 
        595                 600                 605             


Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln Glu Val 
    610                 615                 620                 


Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu Phe Leu 
625                 630                 635                 640 


Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser Pro Ala 
                645                 650                 655     


Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro Asn Tyr 
            660                 665                 670         


Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly Glu Thr 
        675                 680                 685             


Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu Pro Val 
    690                 695                 700                 


Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly Arg Val 
705                 710                 715                 720 


Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr Asp Ser 
                725                 730                 735     


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys Asp Lys 
            740                 745                 750         


Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro 
        755                 760                 765             


Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr Trp Ile 
    770                 775                 780                 


Glu Gly Val Met Arg Asn Asn 
785                 790     


<210>  34
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  34

Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
1               5                   10                  15      


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
            20                  25                  30          


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly 
        35                  40                  45              


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    50                  55                  60                  


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
65                  70                  75                  80  


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
                85                  90                  95      


Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser 
            100                 105                 110         


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        115                 120                 125             


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    130                 135                 140                 


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
145                 150                 155                 160 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
                165                 170                 175     


Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            180                 185                 190         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        195                 200                 205             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    210                 215                 220                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
225                 230                 235                 240 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                245                 250 


