                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
 
<120> LIGHT-INDUCIBLE CRISPR/CAS9 SYSTEM FOR GENOME EDITING

<130> 048317-569001WO

<140> PCT/US2020/057256
<141> 2020-10-25

<150> 62/926,412
<151> 2019-10-25

<160> 64    

<170> PatentIn version 3.5

<210> 1
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
gcuauucucg cagcucacca guuuuagagc uaugcuguuu ug                          42


<210> 2
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
guuacuagac cuauagcuac guuuuagagc uaugcuguuu ug                          42


<210> 3
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
guaauuccag cgagaggcag guuuuagagc uaugcuguuu ug                          42


<210> 4
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
gacuuccucu augguggcgu guuuuagagc uaugcuguuu ug                          42


<210> 5
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
uccucuguau gauaucacag guuuuagagc uaugcuguuu ug                          42


<210> 6
<211> 33
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
ugauaucaca gguuuuagag cuaugcuguu uug                                    33


<210> 7
<211> 67
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210> 8
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
tggcggccta aggactcg                                                     18


<210> 9
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
gaagccggcc ttgcacatg                                                    19


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
cacaggagcc tcccggtttc                                                   20


<210> 11
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
cttcagggtg aggatgcctc tc                                                22


<210> 12
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 12
ctcacagcgc gcc                                                          13


<210> 13
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 13
tgctcagggc ttcttg                                                       16


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
ctcagtctga atcctgttaa c                                                 21


<210> 15
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
cctaaagtga actattgtat gag                                               23


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
gtgtctattg tttggcctag t                                                 21


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
gtgagaagga gactcattct                                                   20


<210> 18
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 18
tatcaagcac ggcag                                                        15


<210> 19
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 19
acctcagatc gttc                                                         14


<210> 20
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ttggcgggaa aaagaacgg                                                    19


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
tattcgctcc ggatctccct                                                   20


<210> 22
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gccagcggtc cgcaac                                                       16


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
gagagccttt cagagaagcg g                                                 21


<210> 24
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 24
tatctaactc gctg                                                         14


<210> 25
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      probe

<400> 25
ttgcccatag cagc                                                         14


<210> 26
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
tggcggccta aggactcg                                                     18


<210> 27
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
cttcagggtg aggatgcctc tc                                                22


<210> 28
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
ctcagtctga atcctgttaa c                                                 21


<210> 29
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
cacttctgaa acacttttct tac                                               23


<210> 30
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
ttggcgggaa aaagaacgg                                                    19


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
gagagccttt cagagaagcg g                                                 21


<210> 32
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
gtttccgagg cagcagttg                                                    19


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
gcatgataaa cgtcatcgcc c                                                 21


<210> 34
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
tcgtcggcag cgtcagatgt gtataagaga cagtggcggc ctaaggactc g                51


<210> 35
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
gtctcgtggg ctcggagatg tgtataagag acaggaagcc ggccttgcac atg              53


<210> 36
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
tcgtcggcag cgtcagatgt gtataagaga cagctcagtc tgaatcctgt taac             54


<210> 37
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
gtctcgtggg ctcggagatg tgtataagag acagcctaaa gtgaactatt gtatgag          57


<210> 38
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
tcgtcggcag cgtcagatgt gtataagaga caggggatcg cgctgagtat aaa              53


<210> 39
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
gtctcgtggg ctcggagatg tgtataagag acagtgggca aagtttcgtg ga               52


<210> 40
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
tcgtcggcag cgtcagatgt gtataagaga caggcccatc aaggggatct tga              53


<210> 41
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
aatgatacgg cgaccaccga gatctacacc tctctattcg tcggcagcgt c                51


<210> 42
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
aatgatacgg cgaccaccga gatctacact atcctcttcg tcggcagcgt c                51


<210> 43
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
aatgatacgg cgaccaccga gatctacacg taaggagtcg tcggcagcgt c                51


<210> 44
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
aatgatacgg cgaccaccga gatctacaca ctgcatatcg tcggcagcgt c                51


<210> 45
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
aatgatacgg cgaccaccga gatctacaca aggagtatcg tcggcagcgt c                51


<210> 46
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
aatgatacgg cgaccaccga gatctacacc taagccttcg tcggcagcgt c                51


<210> 47
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
aatgatacgg cgaccaccga gatctacacc gtctaattcg tcggcagcgt c                51


<210> 48
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
aatgatacgg cgaccaccga gatctacact ctctccgtcg tcggcagcgt c                51


<210> 49
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
caagcagaag acggcatacg agattcgcct tagtctcgtg ggctcgg                     47


<210> 50
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
caagcagaag acggcatacg agatctagta cggtctcgtg ggctcgg                     47


<210> 51
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
caagcagaag acggcatacg agatttctgc ctgtctcgtg ggctcgg                     47


<210> 52
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
caagcagaag acggcatacg agatgctcag gagtctcgtg ggctcgg                     47


<210> 53
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
caagcagaag acggcatacg agataggagt ccgtctcgtg ggctcgg                     47


<210> 54
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
caagcagaag acggcatacg agatcatgcc tagtctcgtg ggctcgg                     47


<210> 55
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
caagcagaag acggcatacg agatgtagag aggtctcgtg ggctcgg                     47


<210> 56
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
caagcagaag acggcatacg agatcagcct cggtctcgtg ggctcgg                     47


<210> 57
<211> 425
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      ACTB sequence

<400> 57
tggcggccta aggactcggc gcgccggaag tggccagggc gggggcgact tcggctcaca       60

gcgcgcccgg ctattctcgc agctcaccat ggatgatgat atcgccgcgc tcgtcgtcga      120

caacggctcc ggcatgtgca aggccggctt cgcgggcgac gatgcccccc gggccgtctt      180

cccctccatc gtggggcgcc ccaggcacca ggtaggggag ctggctgggt ggggcagccc      240

cgggagcggg cgggaggcaa gggcgctttc tctgcacagg agcctcccgg tttccggggt      300

gggggctgcg cccgtgctca gggcttcttg tcctttcctt cccagggcgt gatggtgggc      360

atgggtcaga agattcctat gtgggcgacg aggcccagag caagagaggc atcctcaccc      420

tgaag                                                                  425


<210> 58
<211> 427
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 58
tggcggccta aggactcggc gcgccggaag tggccagggc gggggcgact tcggctcaca       60

gcgcgcccgg ctattctcgc agctcaacca tggatgatga tatcgccgcg ctcgtcgtcg      120

acaacggctc cggcatgtgc aaggccggct tcgcgggcga cgatgccccc cgggccgtct      180

tcccctccat cgtggggcgc cccaggcacc aggtagggga gctggctggg tggggcagcc      240

ccgggagcgg gcgggaggca agggcgcttt ctctgcacag gagcctcccg gtttccgggg      300

tgggggctgc gcccgtgctc agggcttctt gtcctttcct tcccagggcg tgatggtggg      360

catgggtcag aaggattcct atgtgggcga cgaggcccag agcaagagag gcatcctcac      420

cctgaag                                                                427


<210> 59
<211> 412
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      MYC sequence

<400> 59
ttggcgggaa aaagaacgga gggagggatc gcgctgagta taaaagccgg ttttcggggc       60

tttatctaac tcgctgtagt aattccagcg agaggcagag ggagcgagcg ggcggccggc      120

tagggtggaa gagccgggcg agcagagctg cgctgcgggc gtcctgggaa gggagatccg      180

gagcgaatag ggggcttcgc ctctggccca gccctcccgc tgatccccca gccagcggtc      240

cgcaaccctt gccgcatcca cgaaactttg cccatagcag cgggcgggca ctttgcactg      300

gaacttacaa cacccgagca aggacgcgac tctcccgacg cggggaggct attctgccca      360

tttggggaca cttccccgcc gctgccagga cccgcttctc tgaaaggctc tc              412


<210> 60
<211> 413
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 60
ttggcgggaa aaagaacgga gggagggatc gcgctgagta taaaagccgg ttttcggggc       60

tttatctaac tcgctgtagt aattccagcg agaggccaga gggagcgagc gggcggccgg      120

ctagggtgga agagccgggc gagcagagct gcgctgcggg cgtcctggga agggagatcc      180

ggagcgaata gggggcttcg cctctggccc agccctcccg ctgatccccc agccagcggt      240

ccgcaaccct tgccgcatcc acgaaacttt gcccatagca gcgggcgggc actttgcact      300

ggaacttaca acacccgagc aaggacgcga ctctcccgac gcggggaggc tattctgccc      360

atttggggac acttccccgc cgctgccagg acccgcttct ctgaaaggct ctc             413


<210> 61
<211> 411
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 61
ttggcgggaa aaagaacgga gggagggatc gcgctgagta taaaagccgg ttttcggggc       60

tttatctaac tcgctgtagt aattccagcg agagcagagg gagcgagcgg gcggccggct      120

agggtggaag agccgggcga gcagagctgc gctgcgggcg tcctgggaag ggagatccgg      180

agcgaatagg gggcttcgcc tctggcccag ccctcccgct gatcccccag ccagcggtcc      240

gcaacccttg ccgcatccac gaaactttgc ccatagcagc gggcgggcac tttgcactgg      300

aacttacaac acccgagcaa ggacgcgact ctcccgacgc ggggaggcta ttctgcccat      360

ttggggacac ttccccgccg ctgccaggac ccgcttctct gaaaggctct c               411


<210> 62
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 62
gtctcgtggg ctcggagatg tgtataagag acagctgggg tctgggtagg taac             54


<210> 63
<211> 11
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      ACTB sequence

<400> 63
gctcaccatg g                                                            11


<210> 64
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
gctcaaccat gg                                                           12


