                         SEQUENCE LISTING

<110>  MICROCURES, INC.
 
<120>  METHODS AND AGENTS FOR ENHANCING T CELL THERAPIES

<130>  P-589147-PC

<140>  PCT/US20/57231
<141>  2020-10-23

<150>  62/926,238
<151>  2019-10-25

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand

<400>  1
uuacacagua uuaaagcgau u                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand

<400>  2
ucgcuuuaau acuguguaau u                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand

<400>  3
caucugaaac cuagggucuu u                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand

<400>  4
agacccuagg uuucagaugu u                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand

<400>  5
gugacuuaug cuaggaggau u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand

<400>  6
uccuccuagc auaagucacu u                                                 21


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand

<400>  7
ggucagaagc agaauguauu u                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand

<400>  8
auacauucug cuucugaccu u                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is deoxythymidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  n is deoxythymidine

<400>  9
cgccggccca caaguuggan n                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand


<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is deoxythymidine


<220>
<221>  modified_base
<222>  (21)..(21)
<223>  n is deoxythymidine

<400>  10
uccaacuugu gggccggcgn n                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to mouse fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is deoxythymidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  n is deoxythymidine

<400>  11
cagcucgagc ccuuugacan n                                                 21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to mouse fidgetin-like 2, antisense strand


<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is deoxythymidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  n is deoxythymidine

<400>  12
ugucaaaggg cucgagcugn n                                                 21


<210>  13
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to rat fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is deoxythymidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  n is deoxythymidine

<400>  13
ccuccaaccu ccucaagagn n                                                 21


<210>  14
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to rat fidgetin-like 2, antisense strand


<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is deoxythymidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  n is deoxythymidine

<400>  14
cucuugagga gguuggaggn n                                                 21


<210>  15
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to pig fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is deoxythymidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  n is deoxythymidine

<400>  15
cguugcugcu caucagcgan n                                                 21


<210>  16
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to pig fidgetin-like 2, sense antisense strand


<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is deoxythymidine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  n is deoxythymidine

<400>  16
ucgcugauga gcagcaacgn n                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-fluorodeoxyuridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is 2'-fluorodeoxydeoxycytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n is 2'-fluorodeoxycytidine

<400>  17
nnnnnnagua uuaaagcgat t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand
       5' phosphodiester cap

<400>  18
ucgcuuuaauacuguguaatt                                                   21


<210>  19
<211>  4711
<212>  DNA
<213>  Human

<400>  19
agtgagctat ggggacacta ctgcactgta gcctgggcaa cagagcaaga ccttgtctca       60

aaaatgtata tatattttgg gctttttttc ctaaaacggg aactacaaca gcatatttgc      120

gagctgatga gagtgaccca gcagagaggg aaatggatca gctctgttga agatgcactg      180

gacaccagaa cacgcccagc ccctcaacca gtggccagag cagcacctgg acgtctcctc      240

caccaccccg tcgccggccc acaagttgga gttgccccct gggggtcgcc aacgctgcca      300

ctacgcttgg gcacacgacg acatctcagc cctcactgcc tccaacctcc taaagcgcta      360

tgcagagaag tactctgggg tcttggattc tccctacgag cgtccggccc tgggcgggta      420

cagcgacgcc tccttcctca acggcgccaa aggggatccc gagccctggc cagggccgga      480

gccaccctac cccttggcct cactccacga aggcctccca ggaaccaaat cgggcggtgg      540

cggcggttcc ggggccctgg ggggctcccc agttttagcc gggaacctcc ctgaacccct      600

ctacgccggc aatgcgtgcg ggggcccatc ggcggcgccc gagtacgcgg ccggctacgg      660

cggggggtac ctggcgccgg gttactgcgc gcagacgggc gccgcgctgc ccccgccgcc      720

cccggccgcg ctcctgcagc ccccaccgcc tccggggtac gggccctcag cgccgctgta      780

caactatccc gcagggggct acgcagcgca gcccggctat ggcgcgctcc cgccgccccc      840

aggcccaccc ccggccccct acctgacccc gggcctgccc gcgcccacgc ccctgcccgc      900

gccggcaccg cccaccgcct atggcttccc cacggccgcg ccgggtgccg aatccgggct      960

gtcgctgaag cgcaaggccg ccgacgaggg gcccgagggc cgctaccgca agtacgcgta     1020

cgagcccgcc aaggcccccg tggctgacgg agcctcctac cccgccgcgg acaacggcga     1080

atgtcggggc aacgggttcc gggccaagcc gccaggagcc gcggaggagg cgtcgggcaa     1140

gtacggtggc ggcgtccccc tcaaggtcct gggctccccc gtctacggcc cgcaactgga     1200

gccctttgaa aagttcccgg agcgggcccc ggctcctcgt ggggggttcg ccgtgccgtc     1260

gggggagact cccaaaggcg tggaccctgg ggccctggag ctggtgacga gcaagatggt     1320

ggactgcggg cccccggtgc agtgggcgga tgtggcgggc cagggcgcgc tcaaggcggc     1380

gctggaggag gagctggtgt ggcccctgct caggccgccc gcctacccgg gcagcctgcg     1440

cccgccgcgg accgtcctgc tctttgggcc gcggggcgcg ggcaaagcgc tgctgggccg     1500

ctgcctcgcc acgcagctgg gcgccacgct gttgcgcctg cgcggcgcga ccctggctgc     1560

gcccggcgcc gccgagggcg cgcgcctcct ccaggccgcc ttcgcggccg cgcgctgccg     1620

cccaccctcc gtactcctca tcagcgagct agaggcgctg ctccccgccc gggacgacgg     1680

cgcggcggca gggggcgcgc tgcaggtgcc gctcctggcc tgcctggacg ggggctgcgg     1740

cgcgggggct gacggcgtgc tggttgtggg caccacctcg cggcccgcgg ctctggacga     1800

ggcgacccgc cggcgcttct ctctccgctt ctacgtggcg ctgcccgaca gcccggcccg     1860

cgggcagatc ctgcagcggg cgctggccca gcagggctgc gcgctcagtg agcgggaact     1920

ggcggcgctg gtgcagggca cgcagggctt ctctgggggc gagctggggc agctgtgcca     1980

gcaggcggcg gccggggcgg gcctcccggg gctgcagcgc cccctctcct acaaggacct     2040

ggaggcggcg ctggccaagg tgggccctag ggcctctgcc aaggaactgg actcgttcgt     2100

ggagtgggac aaaatgtacg gctccggaca ctgacggcgc gcgggggagg ccgcgggagc     2160

cgcagtccct ccgtccccgc cgcctccgcg tgggagggat gtcactgact aaacccggct     2220

ggcaggggct ggagtggtga atgtgggatc ggggacagga ggggtctgcc ggtggatatt     2280

ttttttttcg tgggaaggaa aatgcttctg ccaggcagat gccatatgcg ccgtgtactc     2340

aggtttttcc tatttattgt ggactggaag ctcgccatct ccgcccggca gaccgggcag     2400

atccggcatg ggctggcacc cggggcctta agaactcctg ctctcttgcc acaacgcttt     2460

tgtctcctcg ctatctgaat ggcaccctcc ttctccctca ctctctccat cccattctct     2520

gcattctctt ggttttctct cccttttgct ttgtcgctga cacccctgcc caccccatgc     2580

tggccctgtt tctctcctgc ccctccctcc ccagctctcc atccctcacc ctctgtgctt     2640

ctgtctccat ccctggctct ccagcgtccc tggccttttg gtccctgagc tttaatgcct     2700

ttccctgcct tctgttctta tttggactgc agtggccctt tgcaggagct ctggaggccc     2760

aggggctgag gaggagggtt acccctctac ccatctgaaa cctagggtct agggggatca     2820

aggaaaaaaa gtccccaaag aaggggaatt ttttgtttgt ttttgagggg agatcccaga     2880

aatgtagctt gtttcatatt ttagtcttct tatttttgta aaatgtgtag aatttgctgt     2940

ttttcttttt cttttgacaa ctcaggaaga aactgacctc agaaagaatg ttagactttg     3000

gctgctctcc tgtgtgcccc tcacacctgc cccctccccc ccactccatc caggggacca     3060

aattctccca gacactcaaa aaatgagact tacggggaag gggagaggaa gacccagagg     3120

cctcagtgaa accccagcta ttcctggtca gaagcagaat gtattcctaa gggcttcctc     3180

cccagggccg aggcctaggc atgaatgtgg ggagtgggct gtggggtttg agagaaggga     3240

ggccttattc ctctcctgct gctccccacc ccctgcccca cccaacccct ccgctgagtg     3300

ttttctgtga agggctatcc agagttagga tgcccttgcc caattccttc ctgagaccca     3360

gaaggtaggg tgggagggcc caaatgggaa ggtgacctaa gcagaaagtc tccagaaagg     3420

tcatgtcccc tggccctgcc ttggcagagg tccccagtga cttatgctag gaggattcca     3480

tctgggtaga cagtctggcc acaaaatcag ctactggacc tcagccatct ctgctggagg     3540

ctctgaggag gagtgagcat ccctcacttg tgggggctct gtgaggaaat gtgccttccc     3600

cattcccccg gagtcctagg tctggagctc cagggctggg agagggtgag ggagatgggc     3660

aggggtgttt tctctgacct tgggggctta gtctcagtcc tgcctgaact ttccactagg     3720

cttggaaccc ttccaagaac catatttctc tccttcccac caattttccc ttgatgaggc     3780

tttagcagtt tgctcccacc acccccagcc catttcacaa ctctgatctt agtccaaagc     3840

aggggacacg cccccccacc accacttttt ctctctccca tctcagcctc ctgtgcagtt     3900

ccttgcctgc ccgtgcattt cctagagtct actgcctccc ccctggctgg gagggtgtct     3960

gggggggatc tttcaggggc cctggcaccc agggcctgtg ctggcctagg agtgctgacc     4020

agaaggctgc tctgttcccc cccacccccg ttgctttctg gccccctctt tggagccagc     4080

cacccacagg gctttggtgc ctcagaagca gtgggctgcc gggtcacagc cgcaggctgc     4140

aaaagaccct cggagggagc atggagtgag gggttctctc tcaggtgtgt atgtattggg     4200

gggtgggggt gggtggaggg tgtcagggaa gttggggtgg gatcccagcc ttcccttcaa     4260

gaggcaggga gctctgggag gtggagtccc caccgctttc tctactaggc tcctcctgtt     4320

ccccaggctt ggggagcttt gcacaaggag actgccccca gcctagtggc acctacctca     4380

tgggctctgg ggcaggtagg ggaagggcca gtccagctct ggtaatgctg gggggaggca     4440

taccaaagaa tccaggggca gggagtgggg agggtgactt ccgagctggc ctctcccctt     4500

cctctaccca gactggggct gggatcctct cctcccgctg taaccatttc tacctcattt     4560

tgctgcgtgt tgtacatgga cgtatttatc tcctgtctga cgatgctctg cagttgtggt     4620

ctgtctacct cagaagagac tgtattttaa aagaaagtat tacacagtat taaagcgatg     4680

acatgtggtt tgcaaaaaaa aaaaaaaaaa a                                    4711


<210>  20
<211>  653
<212>  PRT
<213>  Human

<400>  20

Met His Trp Thr Pro Glu His Ala Gln Pro Leu Asn Gln Trp Pro Glu 
1               5                   10                  15      


Gln His Leu Asp Val Ser Ser Thr Thr Pro Ser Pro Ala His Lys Leu 
            20                  25                  30          


Glu Leu Pro Pro Gly Gly Arg Gln Arg Cys His Tyr Ala Trp Ala His 
        35                  40                  45              


Asp Asp Ile Ser Ala Leu Thr Ala Ser Asn Leu Leu Lys Arg Tyr Ala 
    50                  55                  60                  


Glu Lys Tyr Ser Gly Val Leu Asp Ser Pro Tyr Glu Arg Pro Ala Leu 
65                  70                  75                  80  


Gly Gly Tyr Ser Asp Ala Ser Phe Leu Asn Gly Ala Lys Gly Asp Pro 
                85                  90                  95      


Glu Pro Trp Pro Gly Pro Glu Pro Pro Tyr Pro Leu Ala Ser Leu His 
            100                 105                 110         


Glu Gly Leu Pro Gly Thr Lys Ser Gly Gly Gly Gly Gly Ser Gly Ala 
        115                 120                 125             


Leu Gly Gly Ser Pro Val Leu Ala Gly Asn Leu Pro Glu Pro Leu Tyr 
    130                 135                 140                 


Ala Gly Asn Ala Cys Gly Gly Pro Ser Ala Ala Pro Glu Tyr Ala Ala 
145                 150                 155                 160 


Gly Tyr Gly Gly Gly Tyr Leu Ala Pro Gly Tyr Cys Ala Gln Thr Gly 
                165                 170                 175     


Ala Ala Leu Pro Pro Pro Pro Pro Ala Ala Leu Leu Gln Pro Pro Pro 
            180                 185                 190         


Pro Pro Gly Tyr Gly Pro Ser Ala Pro Leu Tyr Asn Tyr Pro Ala Gly 
        195                 200                 205             


Gly Tyr Ala Ala Gln Pro Gly Tyr Gly Ala Leu Pro Pro Pro Pro Gly 
    210                 215                 220                 


Pro Pro Pro Ala Pro Tyr Leu Thr Pro Gly Leu Pro Ala Pro Thr Pro 
225                 230                 235                 240 


Leu Pro Ala Pro Ala Pro Pro Thr Ala Tyr Gly Phe Pro Thr Ala Ala 
                245                 250                 255     


Pro Gly Ala Glu Ser Gly Leu Ser Leu Lys Arg Lys Ala Ala Asp Glu 
            260                 265                 270         


Gly Pro Glu Gly Arg Tyr Arg Lys Tyr Ala Tyr Glu Pro Ala Lys Ala 
        275                 280                 285             


Pro Val Ala Asp Gly Ala Ser Tyr Pro Ala Ala Asp Asn Gly Glu Cys 
    290                 295                 300                 


Arg Gly Asn Gly Phe Arg Ala Lys Pro Pro Gly Ala Ala Glu Glu Ala 
305                 310                 315                 320 


Ser Gly Lys Tyr Gly Gly Gly Val Pro Leu Lys Val Leu Gly Ser Pro 
                325                 330                 335     


Val Tyr Gly Pro Gln Leu Glu Pro Phe Glu Lys Phe Pro Glu Arg Ala 
            340                 345                 350         


Pro Ala Pro Arg Gly Gly Phe Ala Val Pro Ser Gly Glu Thr Pro Lys 
        355                 360                 365             


Gly Val Asp Pro Gly Ala Leu Glu Leu Val Thr Ser Lys Met Val Asp 
    370                 375                 380                 


Cys Gly Pro Pro Val Gln Trp Ala Asp Val Ala Gly Gln Gly Ala Leu 
385                 390                 395                 400 


Lys Ala Ala Leu Glu Glu Glu Leu Val Trp Pro Leu Leu Arg Pro Pro 
                405                 410                 415     


Ala Tyr Pro Gly Ser Leu Arg Pro Pro Arg Thr Val Leu Leu Phe Gly 
            420                 425                 430         


Pro Arg Gly Ala Gly Lys Ala Leu Leu Gly Arg Cys Leu Ala Thr Gln 
        435                 440                 445             


Leu Gly Ala Thr Leu Leu Arg Leu Arg Gly Ala Thr Leu Ala Ala Pro 
    450                 455                 460                 


Gly Ala Ala Glu Gly Ala Arg Leu Leu Gln Ala Ala Phe Ala Ala Ala 
465                 470                 475                 480 


Arg Cys Arg Pro Pro Ser Val Leu Leu Ile Ser Glu Leu Glu Ala Leu 
                485                 490                 495     


Leu Pro Ala Arg Asp Asp Gly Ala Ala Ala Gly Gly Ala Leu Gln Val 
            500                 505                 510         


Pro Leu Leu Ala Cys Leu Asp Gly Gly Cys Gly Ala Gly Ala Asp Gly 
        515                 520                 525             


Val Leu Val Val Gly Thr Thr Ser Arg Pro Ala Ala Leu Asp Glu Ala 
    530                 535                 540                 


Thr Arg Arg Arg Phe Ser Leu Arg Phe Tyr Val Ala Leu Pro Asp Ser 
545                 550                 555                 560 


Pro Ala Arg Gly Gln Ile Leu Gln Arg Ala Leu Ala Gln Gln Gly Cys 
                565                 570                 575     


Ala Leu Ser Glu Arg Glu Leu Ala Ala Leu Val Gln Gly Thr Gln Gly 
            580                 585                 590         


Phe Ser Gly Gly Glu Leu Gly Gln Leu Cys Gln Gln Ala Ala Ala Gly 
        595                 600                 605             


Ala Gly Leu Pro Gly Leu Gln Arg Pro Leu Ser Tyr Lys Asp Leu Glu 
    610                 615                 620                 


Ala Ala Leu Ala Lys Val Gly Pro Arg Ala Ser Ala Lys Glu Leu Asp 
625                 630                 635                 640 


Ser Phe Val Glu Trp Asp Lys Met Tyr Gly Ser Gly His 
                645                 650             


<210>  21
<211>  4535
<212>  DNA
<213>  Human

<400>  21
gggtttgaaa ttccaacatg gcagaggctg cagtccgtct tcccttcaaa aacttggaat       60

gatttcaaat cataggcacc ttcacttaac cctagcttcc attcatcagc aaacacatcg      120

gatcgatgct acgctaacct atcgggttct ctctccgcgc gttcaggtta aatgaatacc      180

tgacgaaagg gcccacgttt caaggcagtg acatttgata gctgagagga aaagtggctt      240

taatgaaaag caacctttgg aattcctgct tgtgagaaat ccaattcagc tttttgtgct      300

gccagcaaga aatgatcagt agcaccagtg tttatggctt gaagatgcag tggacgccag      360

agcatgccca gtggccagaa cagcactttg acatcacctc aaccactcgg tctcctgccc      420

acaaagttga agcctacaga ggtcatctgc agcgcaccta tcagtacgcc tgggcgaatg      480

atgacatatc tgctctgact gcatccaacc tactaaaaaa atatgcagag aagtattccg      540

gcattttgga aggtcctgtg gaccgacccg tactcagcaa ctattcggac acaccatcag      600

gactagtgaa cggtcggaaa aatgaaagtg aaccctggca gccttccttg aattcagaag      660

ctgtttatcc catgaactgt gttccggatg ttatcactgc cagcaaagct ggagtcagtt      720

cagccctccc tccagcagat gtctctgcga gtataggaag ctctcctggg gtagccagca      780

acctgacaga acctagttat tcaagtagta cctgtggaag ccacactgta cccagtcttc      840

atgcagggct cccatctcag gaatatgccc caggatacaa cggatcatat ttgcattcta      900

cttatagtag ccagccagca cctgcacttc cttcacctca tccgtctcct ttgcatagct      960

ctgggctact acagccccca ccaccacctc ctccgccacc agccttggtc ccaggctaca     1020

atgggacttc taacctctcc agttacagct atccgtctgc tagctatcct cctcagactg     1080

ctgtggggtc tgggtacagc cctggggggg caccgcctcc gccttcagcg tacctgcctt     1140

caggaattcc tgctcccacc cccctacccc ccaccactgt tcctggctac acctaccagg     1200

gccatggttt gacacctatt gcaccgtcgg ctctgacaaa cagttcagca agttctctca     1260

aaaggaaagc tttctacatg gcagggcaag gagatatgga ctccagttat ggaaattaca     1320

gctatggcca acagagatct acacagagtc ctatgtacag aatgcccgac aacagcattt     1380

caaacacaaa tcgggggaat ggctttgaca gaagtgctga aacatcatcc ttagcattta     1440

agccaacgaa gcagctaatg tcctctgaac agcaaaggaa attcagcagc cagtccagta     1500

gggctctgac ccctccttcc tacagtactg ctaaaaattc attgggatca agatccagtg     1560

aatcctttgg gaagtacaca tcgccagtaa tgagtgagca tggggacgag cacaggcagc     1620

tcctctctca cccaatgcaa ggccctggac tccgtgcagc tacctcatcc aaccactctg     1680

tggacgagca actgaagaat actgacacgc acctcatcga cctggtaacc aatgagatta     1740

tcacccaagg acctccagtg gactggaatg acattgctgg tctcgacctg gtgaaggctg     1800

tcattaaaga ggaggtttta tggccagtgt tgaggtcaga cgcgttcagt ggactgacgg     1860

ccttacctcg gagcatcctt ttatttggac ctcgggggac aggcaaaaca ttattgggca     1920

gatgcatcgc tagtcagctg ggggccacat ttttcaaaat tgccggttct ggactagtcg     1980

ccaagtggtt aggagaagca gagaaaatta tccatgcctc ttttcttgtg gccaggtgtc     2040

gccagccctc ggtgattttt gttagtgaca ttgacatgct tctctcctct caagtgaatg     2100

aggaacatag tccagtcagt cggatgagaa ccgaatttct gatgcaactg gacactgtac     2160

taacttcggc tgaggaccaa atcgtagtaa tttgtgccac cagtaaacca gaagaaatag     2220

atgaatccct tcggaggtac ttcatgaaac gacttttaat cccacttcct gacagcacag     2280

cgaggcacca gataatagta caactgctct cacagcacaa ttactgtctc aatgacaagg     2340

agtttgcact gctcgtccag cgcacagaag gcttttctgg actagatgtg gctcatttgt     2400

gtcaggaagc agtggtgggc cccctccatg ccatgccagc cacagacctt tcagccatta     2460

tgcccagcca gttgaggccc gttacatatc aagactttga aaatgctttc tgcaagattc     2520

agcctagcat atctcaaaag gagcttgata tgtatgttga atggaacaaa atgtttggtt     2580

gcagtcagtg ataacttctt tagaaaaaaa aaatgtaatg aatgttggca cacacacata     2640

aaacctgcta catagggaat agagcccctt tccagtagag tttaaattgc aaagggtact     2700

ggggaagatg acgattaagt tgcatcttta gagtcagggt agatttggag gaaaagtgca     2760

tcaaatgaga gcttctgatt tgaaagcccc agatgacaga aagcatatgt ggatgctcag     2820

ttctgttcaa gctagacaac actcaccaag gagcaaggtg caagtgtgtt gatttcagaa     2880

ggacatgaac ctcgtgtgtt gattccattc tgctgttctc gagatttagt tgctgtcaag     2940

tgcctggagt ggtgctttat tttttgtttg cctcacaatt acattggtgg catgtgctaa     3000

tataaagagc tttaacttca aacattattg gactaaagag atgaacagtt gtgttatgac     3060

agaaaaccag atttttgcca ttttaagagc aacagtattc ctcaatcctg tctgttctgc     3120

agtattaagc taagaacagg taaaacaggg taacggtaat ctggacctta atttctgcag     3180

ttcatttctt ttaatgttct tgtctgcaaa aactcaggaa agtgattgtg atttgtacag     3240

tacctcaaag gaatgtgttg aaagcactat gtactgctga gagtaatagg ataggcttca     3300

atgttacttt atattaaaat gtatgtttac ctcaacaatt ggaaaatagc aaggaaaatt     3360

actttgaatg tatccagaaa aatactgaag tgtgatacaa ctgaatattt acagtttaaa     3420

gtagaaatgg aaggattttt ttaagttctt ttactaatta tggggaatta accagagcag     3480

aataattctt tatgtcaata actgcaagag ttcttagtac attgctcctt gataattaag     3540

tgaaaatgtt cttaaaaggt acactggtta attgaaagct acttattcag tttgtgttag     3600

tgtctagacc tgtcagccac aagacctgtt taggaccctg aaagtcacag tacctaaaaa     3660

ctatgactgc ctttttattg cataggtggt agtggtggtg atggtggtgg tagtttgcaa     3720

gttatctctt aaaactgctg ggaatggtgt cattctattc actaatctag cttatagact     3780

tgccgtgctg tttgatagaa tgcagaggat agcaaccaaa acaaatacac aaataaataa     3840

aaacaaaaac caaccaacaa accaacttac atacacatat atatatccac aaagaacctc     3900

tccatctcct ccccttcttt ttgactccac tcttgtcagt gcaattttgc ttctcatttt     3960

gaaatctggg ctgtagtgct cctgctttat ttctacctca gttttgttac atttctcttg     4020

gaaagtaaag tagaaaattg gaagtggaca cacacactgc aatgtagctt gccaaacatg     4080

ttactttgtt ttcttccatc tttcaccgta aatctagttt ccaaagacat cagcatttgt     4140

gcttacttcc acctcagtct accagcccca cccctaccca tggcataagt ggcatttttc     4200

ttaatttcct atttttctcc tgctctctgt caagttgttc tttgtatcct ttaatgcttt     4260

atgtgcaacc tttcattgat agtgggctga tgtttggcaa tgcttctgaa ctgtcacaga     4320

gcaggctgta gctttccaca gccactgccc atgcataagc agaacagcct ggccttttga     4380

atgtattttc ctgggttttt tccccttttc tttttttagt ttagagatgc agtaacaaaa     4440

ctgttgcaaa gcactggcat tttatgtatt caataaataa gtgatgtaca tttttaaaaa     4500

aatttaaata aatgcaatga gaagccccaa gaaag                                4535


<210>  22
<211>  759
<212>  PRT
<213>  Human

<400>  22

Met Ile Ser Ser Thr Ser Val Tyr Gly Leu Lys Met Gln Trp Thr Pro 
1               5                   10                  15      


Glu His Ala Gln Trp Pro Glu Gln His Phe Asp Ile Thr Ser Thr Thr 
            20                  25                  30          


Arg Ser Pro Ala His Lys Val Glu Ala Tyr Arg Gly His Leu Gln Arg 
        35                  40                  45              


Thr Tyr Gln Tyr Ala Trp Ala Asn Asp Asp Ile Ser Ala Leu Thr Ala 
    50                  55                  60                  


Ser Asn Leu Leu Lys Lys Tyr Ala Glu Lys Tyr Ser Gly Ile Leu Glu 
65                  70                  75                  80  


Gly Pro Val Asp Arg Pro Val Leu Ser Asn Tyr Ser Asp Thr Pro Ser 
                85                  90                  95      


Gly Leu Val Asn Gly Arg Lys Asn Glu Ser Glu Pro Trp Gln Pro Ser 
            100                 105                 110         


Leu Asn Ser Glu Ala Val Tyr Pro Met Asn Cys Val Pro Asp Val Ile 
        115                 120                 125             


Thr Ala Ser Lys Ala Gly Val Ser Ser Ala Leu Pro Pro Ala Asp Val 
    130                 135                 140                 


Ser Ala Ser Ile Gly Ser Ser Pro Gly Val Ala Ser Asn Leu Thr Glu 
145                 150                 155                 160 


Pro Ser Tyr Ser Ser Ser Thr Cys Gly Ser His Thr Val Pro Ser Leu 
                165                 170                 175     


His Ala Gly Leu Pro Ser Gln Glu Tyr Ala Pro Gly Tyr Asn Gly Ser 
            180                 185                 190         


Tyr Leu His Ser Thr Tyr Ser Ser Gln Pro Ala Pro Ala Leu Pro Ser 
        195                 200                 205             


Pro His Pro Ser Pro Leu His Ser Ser Gly Leu Leu Gln Pro Pro Pro 
    210                 215                 220                 


Pro Pro Pro Pro Pro Pro Ala Leu Val Pro Gly Tyr Asn Gly Thr Ser 
225                 230                 235                 240 


Asn Leu Ser Ser Tyr Ser Tyr Pro Ser Ala Ser Tyr Pro Pro Gln Thr 
                245                 250                 255     


Ala Val Gly Ser Gly Tyr Ser Pro Gly Gly Ala Pro Pro Pro Pro Ser 
            260                 265                 270         


Ala Tyr Leu Pro Ser Gly Ile Pro Ala Pro Thr Pro Leu Pro Pro Thr 
        275                 280                 285             


Thr Val Pro Gly Tyr Thr Tyr Gln Gly His Gly Leu Thr Pro Ile Ala 
    290                 295                 300                 


Pro Ser Ala Leu Thr Asn Ser Ser Ala Ser Ser Leu Lys Arg Lys Ala 
305                 310                 315                 320 


Phe Tyr Met Ala Gly Gln Gly Asp Met Asp Ser Ser Tyr Gly Asn Tyr 
                325                 330                 335     


Ser Tyr Gly Gln Gln Arg Ser Thr Gln Ser Pro Met Tyr Arg Met Pro 
            340                 345                 350         


Asp Asn Ser Ile Ser Asn Thr Asn Arg Gly Asn Gly Phe Asp Arg Ser 
        355                 360                 365             


Ala Glu Thr Ser Ser Leu Ala Phe Lys Pro Thr Lys Gln Leu Met Ser 
    370                 375                 380                 


Ser Glu Gln Gln Arg Lys Phe Ser Ser Gln Ser Ser Arg Ala Leu Thr 
385                 390                 395                 400 


Pro Pro Ser Tyr Ser Thr Ala Lys Asn Ser Leu Gly Ser Arg Ser Ser 
                405                 410                 415     


Glu Ser Phe Gly Lys Tyr Thr Ser Pro Val Met Ser Glu His Gly Asp 
            420                 425                 430         


Glu His Arg Gln Leu Leu Ser His Pro Met Gln Gly Pro Gly Leu Arg 
        435                 440                 445             


Ala Ala Thr Ser Ser Asn His Ser Val Asp Glu Gln Leu Lys Asn Thr 
    450                 455                 460                 


Asp Thr His Leu Ile Asp Leu Val Thr Asn Glu Ile Ile Thr Gln Gly 
465                 470                 475                 480 


Pro Pro Val Asp Trp Asn Asp Ile Ala Gly Leu Asp Leu Val Lys Ala 
                485                 490                 495     


Val Ile Lys Glu Glu Val Leu Trp Pro Val Leu Arg Ser Asp Ala Phe 
            500                 505                 510         


Ser Gly Leu Thr Ala Leu Pro Arg Ser Ile Leu Leu Phe Gly Pro Arg 
        515                 520                 525             


Gly Thr Gly Lys Thr Leu Leu Gly Arg Cys Ile Ala Ser Gln Leu Gly 
    530                 535                 540                 


Ala Thr Phe Phe Lys Ile Ala Gly Ser Gly Leu Val Ala Lys Trp Leu 
545                 550                 555                 560 


Gly Glu Ala Glu Lys Ile Ile His Ala Ser Phe Leu Val Ala Arg Cys 
                565                 570                 575     


Arg Gln Pro Ser Val Ile Phe Val Ser Asp Ile Asp Met Leu Leu Ser 
            580                 585                 590         


Ser Gln Val Asn Glu Glu His Ser Pro Val Ser Arg Met Arg Thr Glu 
        595                 600                 605             


Phe Leu Met Gln Leu Asp Thr Val Leu Thr Ser Ala Glu Asp Gln Ile 
    610                 615                 620                 


Val Val Ile Cys Ala Thr Ser Lys Pro Glu Glu Ile Asp Glu Ser Leu 
625                 630                 635                 640 


Arg Arg Tyr Phe Met Lys Arg Leu Leu Ile Pro Leu Pro Asp Ser Thr 
                645                 650                 655     


Ala Arg His Gln Ile Ile Val Gln Leu Leu Ser Gln His Asn Tyr Cys 
            660                 665                 670         


Leu Asn Asp Lys Glu Phe Ala Leu Leu Val Gln Arg Thr Glu Gly Phe 
        675                 680                 685             


Ser Gly Leu Asp Val Ala His Leu Cys Gln Glu Ala Val Val Gly Pro 
    690                 695                 700                 


Leu His Ala Met Pro Ala Thr Asp Leu Ser Ala Ile Met Pro Ser Gln 
705                 710                 715                 720 


Leu Arg Pro Val Thr Tyr Gln Asp Phe Glu Asn Ala Phe Cys Lys Ile 
                725                 730                 735     


Gln Pro Ser Ile Ser Gln Lys Glu Leu Asp Met Tyr Val Glu Trp Asn 
            740                 745                 750         


Lys Met Phe Gly Cys Ser Gln 
        755                 


<210>  23
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA to human fidgetin-like 2

<400>  23
caccgctgga gccctttgac aagttctcga gaacttgtca aagggctcca gctttt           56


<210>  24
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin

<400>  24
acuagugaac ggucggma                                                     18


<210>  25
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin

<400>  25
gcagagaagu auuccggca                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin

<400>  26
ggccaugguu ugacaccua                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin

<400>  27
aguugaggcc cguuacaua                                                    19


<210>  28
<211>  13024
<212>  DNA
<213>  Human

<400>  28
gtcagtcccc gcgcttttcg gaggctgcca gcgtcccaca ccagccgcag gtaggatgcg       60

gtgacgggag gcggggcagg ggcgctgctg acccctgtgg agcatcaggg ttggggcgta      120

ggggagaggc gggcgtgtgc ctctggaatg ctgggggtcg cggggcggtg acttcgcggg      180

aggccgtggg aggcgggagc caggcagtgg ctgtgccctt ttgcttctgt cttagcggga      240

gggtggctga cccgctagcc cagaaccaga ctcatccagg attaggaagc tggggcccgg      300

cgtggacggc aggctcgggg ccaggtctgc gggcggcttc ctttggcaga gcctgtccgg      360

gggcggggcc gcttaccgca ggcatttact gggcccagcg gggctctggg cgcccacagc      420

gggggtcagt cagttcccct gtgacccagg caagctctta atctctgtga tgagaaagaa      480

gggctcatac ctttcagggg tcatcgtgag gaatcagaag aagcagtatt ttatagagta      540

ttttctaagt gctgagtcct ctgtctagtg ctttgcagaa ttaaaatacc ttgtcagctc      600

agtgatgttg ctgcgcttct tttataggtg aaaaccggca gaaagacatt aagagatttt      660

cctgcagtca ctgctggcag atgatagagc caggatttga aagcaggcag cctggctcca      720

gaccctgtgc tcttaactcc cgttttgcat caagaacaga atcctatgaa aggcttgcac      780

agtgcttggt actgagtagg cactccgtca gtattttagt agctattatt ccaaaggaca      840

ctgtattcta ggtactaaga caatgtgaat ggaatggaaa acaattcctc cctgcagaag      900

ccaactgtct aggaagacag ataatgacat tattaaaata atcagaacat tggcaaaata      960

aagaagattg aaatgcagtt catatgacag tgctaattaa tcatactttt tagatctagg     1020

aaaggccata aaggttaaat tgacttggaa atggtaaaca agacaatggt tgtgtcactg     1080

atcggtgatg gccagttttt ggttatcctt atttgccatt taaatgattg aattgaaagg     1140

aagaagtaag acttggaaga tgaatattga aggaaaggtg aagatggaaa agagaagggg     1200

gtttattctg agaacagtga ctagaactct gaggtatggt agaaatttca ggataacaga     1260

tgataaaggg gaatgaagcc atggagagga agagaatgat aatattaatt gtgaaagttt     1320

gtgtcaagtg ttttctgagt cacctttctt tcagtttctc atttctagta ttgtataaat     1380

gagtttaaca tcaaaatggt atagtgaaaa aaaggatgaa ctgcttgaca gaagaggtca     1440

gatctagttt tgactctagc ttatttagct ttacagcttt aaataaatta cagtgtcttt     1500

aaagctctgg atcttaagtt ttctaattgt tttttaaaca aagatttgtg aacacctact     1560

tacaatgtga caaatgtctt tgtaaggcat tatgggagat aaaagctgca ttaaacctgg     1620

ctgttgtact tacaagtaat ttggaaggca aaatttcaaa tacttgaacc taaagtaggg     1680

tttcttggtt ttcatttaat tgaaatactg ttaggaaaca aaaatttttc ataaattttt     1740

cttgtggata tgtaagtaaa ttctatatat ctagcaatat gatacatcta tagttctgtt     1800

taaaggtaac aatgtgagga agcttatgcg aataacttga cagaagaaat ctaaagtaaa     1860

agcattttcc tagtaggcta gcttgttctc ttatttcatt tattgtaaca gtttcacttt     1920

ttaataatta tgtgaaatta ggaaacagat attctagggc attctgttta gggtgatgaa     1980

cttattcatg aatgttatta aaaccattta aatatgccat agtttaaatt tgtgatccat     2040

gctgttcaat ctgtgaccta ggatagcagc atcaaggagc attgtgtaca tgcagaagtg     2100

cacagtacct ggagtgaaac tgcttgtgtt cgatttctga taccattcat aactggctgt     2160

gtgatctcaa gtaagttctt taagtctctc agcctcggtt tgtacatttg tgtgataagg     2220

ataatgatag ttttcagatt attttcatag tcattgcttg atttgattct tccaatggtt     2280

cctctcactt tgcagataag aaaactgaag aaccagctgg gcgcggtagc tcacgcctgt     2340

aatcccagca ctttgggagg ctgaggcggg tggattacct gaggtcagga gttcaagacc     2400

agcctgacta acatggcgaa accccatctc tactaaaaat ataaaaatta tccaggggtg     2460

gtggcaggtg cctgtaatcc cagctacttg ggaagctggg gcaggagaag cacttgaacc     2520

cgcgaggtgg aggttgcagt gagctgagag cgccactgcc ctccagcagc ctgggtgaca     2580

gagcgagaca ctgtctcaaa aaaaaataat aataaaataa aaataaacca tcagtgatag     2640

taaaaagctc acttaagctc attcacctag ttttatagat cagacttaaa cctcttgttt     2700

attttgtttt gctttatgta tctatagttc cattgttttt aaaatttaaa attaatttta     2760

aaccttatga atgctttccc tacagataaa attatgtaac tagaacaatt taactcatat     2820

aaattattat ttaatcaagt ccttaatttt gaagacttca tattgatatg tcttgaatac     2880

ttgaaatcta tagttaacta gatatttctc ttataacctg tccttataaa tctacattat     2940

aaataaaaag tccagtgtcc cttccttcag attagcagaa gtttcaaaat tacatttaaa     3000

gtattttctt tgttttcctt catactgatt ttcattttta ttgtttgtta tagaacctct     3060

aaaatgcaga cctccagctc tagatctgtg cacctgagtg aatggcagaa gaattacttc     3120

gcaattacat ctggcatatg taccggaccg aaggcagatg cataccgtgc acagatatta     3180

cgcattcagt atgcatgggc aaactctgag atttcccagg tctgtgctac caaactgttc     3240

aaaaaatatg cagagaaata ttctgcaatt attgattctg acaatgttga atctgggttg     3300

aataattatg cagaaaacat tttaactttg gcaggatctc aacaaacaga tagtgacaag     3360

tggcagtctg gattgtcaat aaataatgtt ttcaaaatga gtagtgtaca gaagatgatg     3420

caagctggca aaaaattcaa agactctctg ttggaacctg ctcttgcatc agtggtaatc     3480

cataaggagg ccactgtctt tgatcttcct aaatttagtg tttgtggtag ttctcaagag     3540

agtgactcat tacctaactc agctcatgat cgagaccgga cccaagactt cccggagagc     3600

aatcgtttga aactccttca gaatgcccag ccacctatgg tgactaacac tgctaggact     3660

tgtcctacat tctcagcacc tgtaggtgag tcagctactg caaaattcca tgtcacacca     3720

ttgtttggaa atgtcaaaaa ggaaaatcac agctctgcaa aagaaaacat aggacttaat     3780

gtgttcttat ctaaccagtc ttgttttcct gctgcctgtg aaaatccaca gaggaagtct     3840

ttttatggtt ctggcaccat tgatgcactt tccaatccaa tactgaataa ggcttgtagt     3900

aaaacagaag ataatggccc aaaggaggat agcagcctgc ctacatttaa aactgcaaaa     3960

gaacaattat gggtagatca gcaaaaaaag taccaccaac ctcagcgtgc atcagggtct     4020

tcatatggtg gtgtaaaaaa gtctctagga gctagtagat cccgagggat acttggaaag     4080

tttgttcctc ctatacccaa gcaagatggg ggagagcaga atggaggaat gcaatgtaag     4140

ccttatgggg caggacctac agaaccagca catccagttg atgagcgtct gaagaacttg     4200

gagccaaaga tgattgaact tattatgaat gagattatgg atcatggacc tccagtaaat     4260

tgggaagata ttgcaggagt agaatttgct aaagccacca taaaggaaat agttgtgtgg     4320

cccatgttga ggccagacat ctttactggt ttaaggggac cccctaaagg aattttgctc     4380

tttggtcctc ctgggactgg taaaactcta attggcaagt gcattgctag tcagtctggg     4440

gcaacattct ttagcatctc tgcttcatcc ttaacttcta aatgggtagg tgagggggag     4500

aaaatggtcc gtgcattgtt tgctgttgca aggtgtcagc aaccagctgt gatatttatt     4560

gacgaaattg attccttgtt atctcaacgg ggagatggtg agcatgaatc ttctagaagg     4620

ataaaaacag aatttttagt tcaattagat ggagcaacaa catcttctga agatcgtatc     4680

ctagtggtgg gagcaacaaa tcggccacaa gaaattgatg aggctgcccg gagaagattg     4740

gtgaaaaggc tttatattcc cctcccagaa gcttcagcca ggaaacagat agtaattaat     4800

ctaatgtcca aagagcagtg ttgcctcagt gaagaagaaa ttgaacagat tgtacagcag     4860

tctgatgcgt tttcaggagc agacatgaca cagctttgca gggaggcttc tcttggtcct     4920

attcgcagtt tacaaactgc tgacattgct accataacac cggatcaagt tcgacccata     4980

gcttacattg attttgaaaa tgcttttaga actgtgcgac ctagtgtttc tccaaaagat     5040

ttagagcttt atgaaaactg gaacaaaact tttggttgtg gaaagtaagt gggatacttg     5100

gaatcaaggc atctctgtag tacagtcttc tttatttttt agcatagaaa gttggggatg     5160

tgttaattgt atttttaaga atatattcta agttctgtac ttcaaataat agcacagatt     5220

ttacatctga ttgacatagt gtatgttaat gtaagttttg ctttccagtg attacctgat     5280

acgtaagcct atttgaacaa agtgagaatg aacttttgtt tctaagaagt ctttatcttg     5340

aagctatata acatgaaaag tgagctcaaa ttttttttag ttgaagatta catataaagt     5400

tgtgtctgat taatattcat cttttattga agaaagtgcc ttctgatggc cacataattc     5460

ttaatgtcag ctagtataat ggtttacatt tggacaaagt attgcttagt gttatttaag     5520

tagatttaag atctcaaagc taaagtgcca atttttactt tcttcagcca atttgttacc     5580

tcttttatgg tttttaattt ttatcaggac taacattttc agaaatagca aggtgtgatc     5640

tagtattaga ttcacagaac tgaaaggtta attaagaatg ttggttattt tcacgggagc     5700

gtgtgatatt taacattaat attttatttg acactacagc ctgtaatact gctctctttc     5760

aaaaacaagt tttcagattt ttataacaga cccattttgt tttatgaaac atgttcatta     5820

cagaaacatg agaaaataga gataagtaaa aagaataaaa gtcactatta tcctaccact     5880

ttgcgggaca cactattaat atttaagcat agattcttcc agatgttttg ttttatacag     5940

cagtaggatt gtgtaatgta ttctctcttg tagcctattc ttcaaagcgt atcttcactt     6000

tccatgttaa cataaatgtc cttttatgat tgtctaggat tccatggatg gatggaatat     6060

aattgagtca tctggtagag cgcatatagg acaggacgct aggttgttta tcttttgttt     6120

attgtaaagg aactatgtgg gatgcatttg gtgatctttt taaaaaatgt ataaatttct     6180

tgagtaattc ctggattaaa gaatatgcac tttttaaagc ttttggcttg cattctaaat     6240

tgtcctcttg aaaaagtagt tcctgtgtaa aactccatct gcactgaatc agagctatgg     6300

cagcattggg cagtaggcag ttttggtatt tgttggcatt ctttttgcat ttattcaaaa     6360

aactgaaggt agtgaacgta gagcaatgaa caacacaaat atccttggtc tcgtggaggt     6420

tatatttaag ttctaatgtt ttctcttgtg aacagtgcaa tttgaaatga caaattgaaa     6480

cacttttagt tgttgaattt agacagtttg tgtatatagt ttaaattttt attcttggtt     6540

tgccttctgt ttttatgtta aaagattgtt gcaattttta gtttttccct ttgtaatatg     6600

tgattgtctt tcattagaat tcattttttg ttttgttttg gttattttga aacagtctcg     6660

ctgtgttgcc taggctggag tgcagtggtg tgatctcagc tcactgcaac ctctgcctcc     6720

tgggttccag tgattcttgt gcctcagtct cccttgtagc tgagaccaca ggtttgcacc     6780

accacaccca gctaattttt gtatttttaa tcgagatggg gtttcaccat gttgcccagg     6840

ctgctctcga actcctggcc tcaaacgatc cacccacctc agcctcctga agtgttggga     6900

ttacaggcat gagccaccac gcctggcctt ttttattaga atttggacgt taaacttctt     6960

gtcttcagtt cttagttata tcttttaaca tcctaaaaca ttccacaata ttcattactg     7020

tctttatccc tttctatttc tatataaaca gcactataaa cttggtttct ttggtattga     7080

tgtcaaggaa ttctctagtt tttctttctt ggtgtttaat tgcagatcac tcccaccttc     7140

ttgggtctag ctatttagat ttatcagcat ttgccctcta gctgttaatg ttttatttag     7200

ctctgaaatt tggtcttaat atttattatc agtttttttc agttacagct tctgccagcc     7260

ctgactttaa gctcccttga tcaccagcca cagggccact tctttctatg gagtttagaa     7320

attgtgacaa ggagagaaag tctagttggt ttagctcatc ttggattaag cagagcccat     7380

gtctctcttg ttagctcaag aaatggtctt tcctgaatta aggtctactc tgttaaataa     7440

gaatctaaac ctgaaaggaa tagtcaggat attttaaagc tggaaagaaa atttgagctg     7500

gggagtcaac tgttgtttct acgttatacc acagagaagc tttctttgtc tcaacacttt     7560

gtgattttga gtgtttctga agcagttgga taggaagctt actgaaactt taagattgct     7620

tactctcgcc acatgcgatt gtcttcatcg aatataataa tcttggatta aattatctca     7680

agtgtggcac tgccctgtct ttagctattg tttcagaaac atgaatgcta gcctgatatt     7740

taatgtcttc aaaaattaca ttcccttagt agaaatacac attttactaa acatgtcact     7800

tggttatggt attaatgctt aacaattttg atatgaatat ggtaattcta atttatgatt     7860

tcaggccttc ttaaatcttt attatacatc taataataat atatgatcct tttgatatgt     7920

attcattctg tggtaaattt ctaattttct gaaattttaa ctcattttct caattctaaa     7980

atatctctca ggtgtgcctt tcatattgac aagctggtct taatggaatc atagtctaaa     8040

gatcatgggc tgtggagcca aatagacctg ttgaattctg gctctgtcat ttactggtga     8100

ctgttggtta cttaattatt caatctcaat tctaaagtga gaatagttta tacctgtctt     8160

gttggagagt gaggattaaa tagtaaaata cagatttaaa aggcctggtt catgttttat     8220

gattgtgcct cttctttgaa tctgccttga ttttgctctt gttgctgtga aggatctttt     8280

cagctatttt gtgtggttgt cctagctcat tctgcttagt gtttgtggta tttgcatcat     8340

attattagag atcatatgcc atctatcttt agttttgtgg aaaaattcta attccaaaga     8400

aatatctctt agttatgttt ctccttttct acactttaga acttttttaa aggtctgtcc     8460

cagattatta tttttctcta ctcatgctta tatgttattt attggtctcc atttttactc     8520

tcccagtgtt tttttaaggg acactttaca gcccaccttt agggatctga ttaaaagaaa     8580

ggattctatc aaggtccatg gcaaaaggac aggttggata aagataacat ctttttactt     8640

ccttcttata ttcctagttc ttgaccttag ttggggagct ggtggtgagg gagcacattt     8700

taaacagttt aagcaggtga ggccatcttg aaggtttgcc ccagcagcct gggtgaatgg     8760

agggagtctt gggagaatag ataagatgca gtcaccactt ttaactcttg cccttaaaaa     8820

atacttttac aacacggctt ataatggaaa gagcattaaa atggacatta gaaaactgcc     8880

agtgattcta accttagaga gtttgtacag actccgtaag atttgttttt ttagtgataa     8940

agggaaattg tactggtcat tccttaataa cacatccaga tttctgttat cacttaccaa     9000

aaatttatga atttgagaat tgcttacaca gtatcaggtg ctgggtactg ggaggtacaa     9060

aacaaagtat agtcaggtaa gggctaactt tattactaat ttggctcatt ataaaaacaa     9120

cgggaaaaca tgaagagagg gctttattaa ggagttaagt cagcataatg gaccacttaa     9180

tatataataa ccacttaaga gaaaaagaaa aattaggaag tccacataag gtggcgtttt     9240

ataaaggcaa catgctgttg ttaagggcac ttgggccatt ggtgttttgt gacagctggg     9300

ctcaggcatc tcaacaagca gcggtgtgcc tgctgaccaa cagggcctgc cacggccagt     9360

gaaacacagc tattagagct ctctcaatcc atttctgctc agaaatgtag agatggcagg     9420

ggaaacgtag ctaagtccca ggttcctcgg atatggcgag ggcaagcact cccatattat     9480

aacaacctgt gcagtcagtg agtccagagc agaggccttg tctcctcctt tgctcacctt     9540

cactcactgc cctggactgt caggccccag ttctcatccc catgtgtgat gaagccatgc     9600

agtcccagag agggagccat cagcgcttgg tagtctcatg ctttagtgtc agagttgcac     9660

cttacctttg tatccaagaa atgcatgcag ctcaactttc ccttaaaagg cttctaggaa     9720

aaaactaccc cagcattttt tttcccccag aagaatatat tagcttaata ataaaaggta     9780

tagtaacaaa ctttccattt aaaatagtgg cctaagccac aaatttacct ttcctgcccg     9840

tatgtgcaaa attttcattg aaatgaaaaa atacacacta agaatcaatc cagtgtgatg     9900

ttggaaaaga gagaaggtta ccattttcaa atatgacagg tgtttctgga ggtcacaagg     9960

caaatggtac tgggttgttg gaatccctga gctaaataat ggctgtgaaa atgccagatg    10020

agattggtta tctcagcagt gcctgggctg tacccctagc ttaggcagca aaataggctg    10080

tgggccagtg gtctggtatc tgaaaggatt gccaagacaa gccttgcgga gctcatgccc    10140

aactgttctt gtggaaccac tgggaagtgg agttccctaa atcaggggga gtcatttaca    10200

gtcgcctggc ttttgtgggc cctgcagcct gagaagtgag tcaggatggc aggtacttgg    10260

ttgccacgtt agacagaagc acaagtattt gatgaagcag tggaacttct tgatgtaact    10320

cactcctgtc tcggtaactt tttacctact tccacatttt tttaagggtc gacccccact    10380

tcctacagtt tctctatatc cttgccactg acacatgcag gcttacgcca agacatagag    10440

gaggtcttgc tcacgccaca gttaacacat ctctatccat ggctgggcaa tatgaaagac    10500

aattgctaag gaagctttct cctgtcagca tactgatcac ttttaaagta taacttaaca    10560

ttacttcccc ttgtaaaaat cctccaatag attcccatct aaatgaaaat aaaatccaaa    10620

ttccttccta gagccaaata tcatttctct tcactctcct ttcttacttt ccttcatccc    10680

actggatctt aaggtgcaac aaacatgttt ctcatatagg aagtgtggta ggcagaattc    10740

tgaagatgtt cctccaagag acccatcccc tgcttattca gtcaaatcta ggtactgctg    10800

ggaagggact ttgcagaggt aatgcggtta cagacctgca gatagggagg ttatcttgaa    10860

ttatttgtgt agggccaatc taatttcaca agtccttaaa agcagagaat gttctctggc    10920

tggttagaga agaggagggc taaagaggca gaagaaagat gtggcagaga ggatgtccaa    10980

gattccgagc atgagaagga ttttctctga agttgcagct ctgtgaatca ggagcccatg    11040

cacgaaggct ggagagaagt ctctaggagc tgacaggagc ctccagacaa tagccaacaa    11100

aaaccagagg tgtcagtcct agaactgcat agaagggaat tctgccagca acctaaataa    11160

gccaggaagc ctcacccaga ggttccagat gagaatccag gccggctgac accttgattt    11220

cagtcttatg ggacccagag cagagaaact ggtagagact cctatacttc tgatgtacag    11280

aactgtgggg tcataactgt gtgtggttct aagctgctaa gtttatggta gtttgttaca    11340

gcagcaatgt ggggtaggga acattacact gttctttgag tgtggaaagc tcttccttac    11400

agctgctgct tcaagttagt aaaatataat ttctccagca agacctcctt tgaccactgg    11460

ggagatagcc tccactaact tccaacacgt gcatgccatc actatcatat tatcctacat    11520

tttttattgg taactgttac taactgaaaa tacttatgct tactgtcttt gtctctaatc    11580

ctatttcaca cccattagaa agttctttac agctagggac tttatgtgca cttcacaacc    11640

atgcaagatt catgagactt ctgaaaaacc caacatcatg agaggcaccc agagaagaag    11700

cagagtgatt cccatcaaag aaaaccattg attcaggaga ctgagtagag ctttagaaag    11760

tctcgatccc agaagacatg gtagccacca aattaaaata ggcagctatt gtattagtat    11820

attgttacat aacaatatca ccacaaactt agtgacttta aacaacacac attaatgacc    11880

ttgtagtttc tttcaggctt agctgggtcc tctgcttcag ggacccacag ggctgcaatg    11940

aaggtgttgg tcaggactgt ggtctcatct gaggcttgtt ggggaaggat ccacttctca    12000

gctcacatgg tggttgggca acattcagtt tcttacagat ggctggacag agggcctcag    12060

ttcttgccat ctgttggctg gaggttgccc tcagttcctt gccatgtagg cattccagtg    12120

tggctgcttg cttcctcaaa gccggcaggg gagagagcct ttccagtagc acagatgtta    12180

ctatcttctg taatgtaatc acacaggcaa cactttgtca tctttgctgt attctgtagg    12240

gtgagagcaa gacacaggtc cttcccactc ttagggaagg gtattaaaaa tgacaactac    12300

caggaggtag ggatcatgga gcctgcttca gaatctatca cagctgtgaa ataaaggccc    12360

aggaaacaag aattctaatg gttaaaataa aaatcttagt ggaagaactg aatttttaaa    12420

atggaaaggg ctgaaacaag atagttaaaa ggaagaataa gctgtggaat tattttacaa    12480

tcttcagcag acagagctag agtgaggagt taagtagtat gacagattcc aggtaactaa    12540

tatccatata atggggaatc tatagaaagt aaaaaggaga gaggtagatg ataattgcat    12600

tattgagagc agataattct tctgagtgaa atacatagtt catatcaaaa gcatctactg    12660

agtgtgtggt gttatatata tatgtaggtt tttcatccag ggttctttgg ctcataactc    12720

ccacagccct tacacagtct tgttataatg ttggatgtgt taggcctcag gtaggcctct    12780

ggtgttctgc cctccttcca ctctaatatt ctcccacctt tctgattgtg ggtcttaaga    12840

ctcaaaattc caagaggaca gggttcagag agcttcccaa tagctgaaca tgtggaggtt    12900

ccgggagagt ggtgtgccca ggtagggcat ggaagcttca agcctcttcc cccatacctt    12960

gccctagcgt ttcttcgtct gtattttttc cagtatagag caataaactg gtgaactaag    13020

tgtt                                                                 13024


<210>  29
<211>  674
<212>  PRT
<213>  Human

<400>  29

Met Gln Thr Ser Ser Ser Arg Ser Val His Leu Ser Glu Trp Gln Lys 
1               5                   10                  15      


Asn Tyr Phe Ala Ile Thr Ser Gly Ile Cys Thr Gly Pro Lys Ala Asp 
            20                  25                  30          


Ala Tyr Arg Ala Gln Ile Leu Arg Ile Gln Tyr Ala Trp Ala Asn Ser 
        35                  40                  45              


Glu Ile Ser Gln Val Cys Ala Thr Lys Leu Phe Lys Lys Tyr Ala Glu 
    50                  55                  60                  


Lys Tyr Ser Ala Ile Ile Asp Ser Asp Asn Val Glu Ser Gly Leu Asn 
65                  70                  75                  80  


Asn Tyr Ala Glu Asn Ile Leu Thr Leu Ala Gly Ser Gln Gln Thr Asp 
                85                  90                  95      


Ser Asp Lys Trp Gln Ser Gly Leu Ser Ile Asn Asn Val Phe Lys Met 
            100                 105                 110         


Ser Ser Val Gln Lys Met Met Gln Ala Gly Lys Lys Phe Lys Asp Ser 
        115                 120                 125             


Leu Leu Glu Pro Ala Leu Ala Ser Val Val Ile His Lys Glu Ala Thr 
    130                 135                 140                 


Val Phe Asp Leu Pro Lys Phe Ser Val Cys Gly Ser Ser Gln Glu Ser 
145                 150                 155                 160 


Asp Ser Leu Pro Asn Ser Ala His Asp Arg Asp Arg Thr Gln Asp Phe 
                165                 170                 175     


Pro Glu Ser Asn Arg Leu Lys Leu Leu Gln Asn Ala Gln Pro Pro Met 
            180                 185                 190         


Val Thr Asn Thr Ala Arg Thr Cys Pro Thr Phe Ser Ala Pro Val Gly 
        195                 200                 205             


Glu Ser Ala Thr Ala Lys Phe His Val Thr Pro Leu Phe Gly Asn Val 
    210                 215                 220                 


Lys Lys Glu Asn His Ser Ser Ala Lys Glu Asn Ile Gly Leu Asn Val 
225                 230                 235                 240 


Phe Leu Ser Asn Gln Ser Cys Phe Pro Ala Ala Cys Glu Asn Pro Gln 
                245                 250                 255     


Arg Lys Ser Phe Tyr Gly Ser Gly Thr Ile Asp Ala Leu Ser Asn Pro 
            260                 265                 270         


Ile Leu Asn Lys Ala Cys Ser Lys Thr Glu Asp Asn Gly Pro Lys Glu 
        275                 280                 285             


Asp Ser Ser Leu Pro Thr Phe Lys Thr Ala Lys Glu Gln Leu Trp Val 
    290                 295                 300                 


Asp Gln Gln Lys Lys Tyr His Gln Pro Gln Arg Ala Ser Gly Ser Ser 
305                 310                 315                 320 


Tyr Gly Gly Val Lys Lys Ser Leu Gly Ala Ser Arg Ser Arg Gly Ile 
                325                 330                 335     


Leu Gly Lys Phe Val Pro Pro Ile Pro Lys Gln Asp Gly Gly Glu Gln 
            340                 345                 350         


Asn Gly Gly Met Gln Cys Lys Pro Tyr Gly Ala Gly Pro Thr Glu Pro 
        355                 360                 365             


Ala His Pro Val Asp Glu Arg Leu Lys Asn Leu Glu Pro Lys Met Ile 
    370                 375                 380                 


Glu Leu Ile Met Asn Glu Ile Met Asp His Gly Pro Pro Val Asn Trp 
385                 390                 395                 400 


Glu Asp Ile Ala Gly Val Glu Phe Ala Lys Ala Thr Ile Lys Glu Ile 
                405                 410                 415     


Val Val Trp Pro Met Leu Arg Pro Asp Ile Phe Thr Gly Leu Arg Gly 
            420                 425                 430         


Pro Pro Lys Gly Ile Leu Leu Phe Gly Pro Pro Gly Thr Gly Lys Thr 
        435                 440                 445             


Leu Ile Gly Lys Cys Ile Ala Ser Gln Ser Gly Ala Thr Phe Phe Ser 
    450                 455                 460                 


Ile Ser Ala Ser Ser Leu Thr Ser Lys Trp Val Gly Glu Gly Glu Lys 
465                 470                 475                 480 


Met Val Arg Ala Leu Phe Ala Val Ala Arg Cys Gln Gln Pro Ala Val 
                485                 490                 495     


Ile Phe Ile Asp Glu Ile Asp Ser Leu Leu Ser Gln Arg Gly Asp Gly 
            500                 505                 510         


Glu His Glu Ser Ser Arg Arg Ile Lys Thr Glu Phe Leu Val Gln Leu 
        515                 520                 525             


Asp Gly Ala Thr Thr Ser Ser Glu Asp Arg Ile Leu Val Val Gly Ala 
    530                 535                 540                 


Thr Asn Arg Pro Gln Glu Ile Asp Glu Ala Ala Arg Arg Arg Leu Val 
545                 550                 555                 560 


Lys Arg Leu Tyr Ile Pro Leu Pro Glu Ala Ser Ala Arg Lys Gln Ile 
                565                 570                 575     


Val Ile Asn Leu Met Ser Lys Glu Gln Cys Cys Leu Ser Glu Glu Glu 
            580                 585                 590         


Ile Glu Gln Ile Val Gln Gln Ser Asp Ala Phe Ser Gly Ala Asp Met 
        595                 600                 605             


Thr Gln Leu Cys Arg Glu Ala Ser Leu Gly Pro Ile Arg Ser Leu Gln 
    610                 615                 620                 


Thr Ala Asp Ile Ala Thr Ile Thr Pro Asp Gln Val Arg Pro Ile Ala 
625                 630                 635                 640 


Tyr Ile Asp Phe Glu Asn Ala Phe Arg Thr Val Arg Pro Ser Val Ser 
                645                 650                 655     


Pro Lys Asp Leu Glu Leu Tyr Glu Asn Trp Asn Lys Thr Phe Gly Cys 
            660                 665                 670         


Gly Lys 
        


<210>  30
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 1

<400>  30
agugauuacc ugauacgua                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 1

<400>  31
gugcacagau auuacgcau                                                    19


<210>  32
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 1

<400>  32
gaauaaggcu uguaguma                                                     18


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 1

<400>  33
ggaucaaguu cgacccaua                                                    19


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand

<400>  34
uuacacagua uuaaagcgat t                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       5' phosphodiester cap


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methylcytidine

<400>  35
nngcuuuaau acuguguaat t                                                 21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand
       5' phosphodiester cap
       Phosphorothioate bond between nucleotides 1 and 2 and between 
       nucleotides 2 and 3


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyuridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methylcytidine

<400>  36
nngcuuuaau acuguguaat t                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand
       5' phosphodiester cap


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-fluorodeoxydeoxycytidine

<400>  37
nngcuuuaau acuguguaat t                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand 
       5' phosphodiester cap
       Phosphorothioate bond between nucleotides 1 and 2 and between 
       nucleotides 2 and 3

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-fluorodeoxydeoxycytidine

<400>  38
nngcuuuaau acuguguaat t                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       5' phosphodiester cap
       Phosphorothioate bond between nucleotides 1 and 2 and between 
       nucleotides 2 and 3


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  1 n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<400>  39
nngcuuuaau annnnnnnnt t                                                 21


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand 
       5' phosphodiester cap
       Phosphorothioate bond between nucleotides 1 and 2

<400>  40
ucgcuuuaau acuguguaat t                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       5' phosphodiester cap

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-fluorodeoxydeoxycytidine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is 2'-fluorodeoxydeoxycytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n is 2'-fluorodeoxydeoxycytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<400>  41
nnnnnnnaan nnngnnnnnt t                                                 21


<210>  42
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (21)..(21)
<223>  n is 2'-O-methyluridine

<400>  42
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  43
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       5' phosphodiester cap


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is 2'-O-methyluridine

<400>  43
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is deoxycytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is deoxyguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is deoxyadenosine

<400>  44
nnnnnnnnnn nnnnnnnnnt t                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is deoxycytidine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<400>  45
nnnnnnnnnn nnnnnnnnnt t                                                 21


<210>  46
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand

<400>  46
uuacacagua uuaaagcga                                                    19


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       5' phosphodiester cap
       Phosphorothioate bond between nucleotides 1 and 2

<400>  47
ucgcuuuaau acuguguaat t                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand
       5' phosphodiester cap

<400>  48
ucgcuuuaau acuguguaat t                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       5' phosphodiester cap
       Phosphorothioate bond between nucleotides 1 and 2 and between 
       nucleotides 2 and 3

<400>  49
ucgcuuuaau acuguguaat t                                                 21


<210>  50
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methyluridine

<400>  50
nnacacagua uuaaagcga                                                    19


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand
       5' phosphodiester cap
       Phosphorothioate bond between nucleotides 1 and 2


<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<400>  51
ucgcuuuaau acugugunnt t                                                 21


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand
       5' phosphodiester cap

<400>  52
ucgcuuuaau acuguguaat t                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       5' phosphodiester cap
       Phosphorothioate bond between nucleotides 1 and 2 and between 
       nucleotides 2 and 3 and between nucleotides 19 and 20

<400>  53
ucgcuuuaau acuguguaat t                                                 21


<210>  54
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is locked uridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is locked uridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is locked adenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is locked cytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is locked adenosine

<400>  54
nnnnncagua uuaaagcgat t                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       5' phosphodiester cap


<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is locked uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is locked guanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is locked uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is locked adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is locked adenosine

<400>  55
ucgcuuuaau acugnnnnnt t                                                 21


<210>  56
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is locked adenosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is 2'-fluorodeoxydeoxycytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is locked adenosine

<400>  56
nnnnncagua uuaaagcga                                                    19


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       5' phosphodiester cap
       Phosphorothioate bond between nucleotides 1 and 2


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methylguanosine

<400>  57
nnncuuuaau acuguguaat t                                                 21


<210>  58
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-fluorodeoxydeoxycytidine

<400>  58
nngcuuuaau acuguguaat t                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand
       Phosphorothioate bond between nucleotides 1 and 2 and between 
       nucleotides 2 and 3

<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-fluorodeoxydeoxycytidine

<400>  59
nngcuuuaau acuguguaat t                                                 21


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 
       Phosphorothioate bond between nucleotides 1 and 2 and between 
       nucleotides 2 and 3


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  1 n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<400>  60
nngcuuuaau annnnnnnnt t                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand 
       Phosphorothioate bond between nucleotides 1 and 2

<400>  61
ucgcuuuaau acuguguaat t                                                 21


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-fluorodeoxydeoxycytidine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is 2'-fluorodeoxydeoxycytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n is 2'-fluorodeoxydeoxycytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is 2'-fluorodeoxydeoxyuridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<400>  62
nnnnnnnaan nnngnnnnnt t                                                 21


<210>  63
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (7)..(7)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is 2'-O-methylguanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (20)..(20)
<223>  n is 2'-O-methyluridine

<400>  63
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  64
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand
       Phosphorothioate bond between nucleotides 1 and 2

<400>  64
ucgcuuuaau acuguguaat t                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand

<400>  65
ucgcuuuaau acuguguaat t                                                 21


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand
       Phosphorothioate bond between nucleotides 1 and 2 and between 
       nucleotides 2 and 3

<400>  66
ucgcuuuaau acuguguaat t                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand
       Phosphorothioate bond between nucleotides 1 and 2


<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is 2'-O-methyladenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is 2'-O-methyladenosine

<400>  67
ucgcuuuaau acugugunnt t                                                 21


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, sense strand

<400>  68
ucgcuuuaau acuguguaat t                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand
       Phosphorothioate bond between nucleotides 1 and 2 and between 
       nucleotides 2 and 3 and between nucleotides 19 and 20

<400>  69
ucgcuuuaau acuguguaat t                                                 21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand 


<220>
<221>  modified_base
<222>  (15)..(15)
<223>  n is locked uridine

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  n is locked guanosine

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  n is locked uridine

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  n is locked adenosine

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  n is locked adenosine

<400>  70
ucgcuuuaau acugnnnnnt t                                                 21 


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand
       Phosphorothioate bond between nucleotides 1 and 2


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  n is 2'-O-methyluridine

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  n is 2'-O-methylcytidine

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  n is 2'-O-methylguanosine

<400>  71
nnncuuuaau acuguguaat t                                                 21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA to human fidgetin-like 2, antisense strand


<400>  72
ucgcuuuaauacuguguaatt                                                   21




