                         SEQUENCE LISTING

<110>  MINOTAUR THERAPEUTICS, Inc.
 
<120>  CHIMERIC CYTOKINE MODIFIED ANTIBODIES AND METHODS OF USE THEREOF

<130>  165772000140

<150>  62/925,740
<151>  2019-10-24

<160>  180   

<170>  PatentIn version 3.5

<210>  1
<211>  114
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL-15

<400>  1

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  2
<211>  77
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IL15-Ralphasushi

<400>  2

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro 
65                  70                  75          


<210>  3
<211>  912
<212>  DNA
<213>  artificial sequence

<220>
<223>  IL-15 Ralphasushi_GSlinker_BLV1H12 light chain

<400>  3
atcacctgcc cacctccaat gagcgtggag cacgcagaca tctgggtgaa gtcttacagc       60

ctgtattccc gggagagata catctgcaac tctggcttca agcggaaggc cggcaccagc      120

tccctgacag agtgcgtgct gaacaaggcc accaatgtgg cccactggac aactccttcc      180

ctgaaatgta ttagagaccc cgccctggtg catcagagac ctgccccccc tggtggaggc      240

ggttcaggcg gaggtggatc ccaggccgtc ctgaaccagc caagcagcgt ctccgggtct      300

ctggggcagc gggtctcaat cacctgtagc gggtcttcct ccaatgtcgg caacggctac      360

gtgtcttggt atcagctgat ccctggcagt gccccacgaa ccctgatcta cggcgacaca      420

tccagagctt ctggggtccc cgatcggttc tcagggagca gatccggaaa cacagctact      480

ctgaccatca gctccctgca ggctgaggac gaagcagatt atttctgcgc atctgccgag      540

gactctagtt caaatgccgt gtttggaagc ggcaccacac tgacagtcct aggtcagccc      600

aaggctgccc cctcggtcac tctgttcccg ccctcctctg aggagcttca agccaacaag      660

gccacactgg tgtgtctcat aagtgacttc tacccgggag ccgtgacagt ggcctggaag      720

gcagatagca gccccgtcaa ggcgggagtg gagaccacca caccctccaa acaaagcaac      780

aacaagtacg cggccagcag ctatctgagc ctgacgcctg agcagtggaa gtcccacaga      840

agctacagct gccaggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctaca      900

gaatgttcat aa                                                          912


<210>  4
<211>  524
<212>  PRT
<213>  artificial sequence

<220>
<223>  IL2 receptor subunit beta

<400>  4

Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn 
1               5                   10                  15      


Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys 
            20                  25                  30          


Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu 
        35                  40                  45              


Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly 
    50                  55                  60                  


Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg 
65                  70                  75                  80  


Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp 
                85                  90                  95      


Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln 
            100                 105                 110         


Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser 
        115                 120                 125             


Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr 
    130                 135                 140                 


Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys 
145                 150                 155                 160 


Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln 
                165                 170                 175     


Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr 
            180                 185                 190         


Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala 
        195                 200                 205             


Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu 
    210                 215                 220                 


Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys 
225                 230                 235                 240 


Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro 
                245                 250                 255     


Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp 
            260                 265                 270         


Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro 
        275                 280                 285             


Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp 
    290                 295                 300                 


Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala 
305                 310                 315                 320 


Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly 
                325                 330                 335     


Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln 
            340                 345                 350         


Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly 
        355                 360                 365             


Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu 
    370                 375                 380                 


Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu 
385                 390                 395                 400 


Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr 
                405                 410                 415     


Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu 
            420                 425                 430         


Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro 
        435                 440                 445             


Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu 
    450                 455                 460                 


Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu 
465                 470                 475                 480 


Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg 
                485                 490                 495     


Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
            500                 505                 510         


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 


<210>  5
<211>  513
<212>  DNA
<213>  artificial sequence

<220>
<223>  BLV1H 12 heavy chain

<400>  5
caggtccagc tgagagagag cggcccttca ctggtcaagc catcccagac actgagcctg       60

acatgcacag caagcgggtt ttcactgagc gacaaggcag tgggatgggt ccgacaggca      120

ccaggaaaag ccctggaatg gctgggcagc atcgataccg gcgggaacac agggtacaat      180

cccggactga agagcagact gtccattacc aaggacaact ctaaaagtca ggtgtcactg      240

agcgtgagct ccgtcaccac agaggatagt gcaacttact attgcacctc tgtgcaccag      300

gaaactaaga aataccagag ctgtcctgac ggctatcggg agagatctga ttgcagtaat      360

aggccagctt gtggcacatc cgactgctgt cgcgtgtctg tcttcgggaa ctgcctgact      420

accctgcctg tgtcctactc ttatacctac aattatgaat ggcatgtgga tgtctgggga      480

cagggcctgc tggtgacagt ctctagtgct agc                                   513


<210>  6
<211>  1557
<212>  DNA
<213>  artificial sequence

<220>
<223>  (Sig Seq- VRegion - CH1CH2CH3) BLV1H12 V in human IgG

<400>  6
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag       60

gtgcagctgc gggagtcggg ccccagcctg atgaagccgt cacagaccct ctccctcacc      120

tgcacggtct ctggatcttc attgaacgac aagtctgtag gctgggtccg ccaggctcca      180

gggaaggcgc tgcagtggct cggtagtgtg gacactagtg gaaacacaga ctataaccca      240

ggcctgaaat cccggctcag catcaccaag gacaactcca agagccgaat ctctcttaca      300

gtgactggca tgacaactga agactcggcc acatactact gtacttctgt gcaccaggaa      360

acaaaaaaat accaaagttg tccggaggat tatacttata atccacgttg ccctcagcag      420

tatggttgga gtgactgtga ttgtatgggc gataggtttg ggggttactg tcgacaggat      480

ggttgtagta attatagtta tacttacaat tacgaatggc acgtcgatgt ctggggccaa      540

ggactcctgg tcaccgtctc ctcagctagc accaagggcc catcggtctt ccccctggca      600

ccctcctcca agagcacctc tgggggcaca gcggccctgg gctgcctggt caaggactac      660

ttccccgaac ctgtgacggt ctcgtggaac tcaggcgccc tgaccagcgg cgtgcacacc      720

ttcccggctg tcctacagtc ctcaggactc tactccctca gcagcgtggt gaccgtgccc      780

tccagcagct tgggcaccca gacctacatc tgcaacgtga atcacaagcc cagcaacacc      840

aaggtggaca agagagttga gcccaaatct tgtgacaaaa ctcacacatg cccaccgtgc      900

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      960

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1020

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1080

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1140

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1200

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1260

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1320

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1380

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag     1440

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1500

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtccccggg taaatga        1557


<210>  7
<211>  823
<212>  DNA
<213>  artificial sequence

<220>
<223>  B15 variable region plus signal peptide

<400>  7
gaattccacc atgggatggt catgtatcat cctttttcta gtagcaactg caaccggagt       60

acattcccag gtgcagctgc gcgagtcggg ccccagcctg gtgaagccgt cacagaccct      120

ctcgctcacc tgcacggcct ctggattctc attgagcgac aaggctgtag gctgggtccg      180

ccaggctcca gggaaggcgc tggagtggct cggtagtata gacactggtg gaaacacagg      240

ctataaccca ggcctgaaat cccggctcag catcaccaag gacaactcca agagtcaagt      300

ctctctgtca gtgagcagcg tgacaactga ggactcggcc acatactact gtacttctgt      360

gcaccaggaa acaaaaaaat accaaaccgg tggatcaaac tgggtgaatg taataagtga      420

tttgaaaaaa attgaagatc ttattcaatc tatgcatatt gatgctactt tatatacgga      480

aagtgatgtt caccccagtt gcaaagtaac agcaatgaag tgctttctct tggagttaca      540

agttatttca cttgagtccg gagatgcaag tattcatgat acagtagaaa atctgatcat      600

cctagcaaac aacagtttgt cttctaatgg gaatgtaaca gaatctggat gcaaagaatg      660

tgaggaactg gaggaaaaaa atattaaaga atttttgcag agttttgtac atattgtcca      720

aatgttcatc aacacttctg gttcaggatc ctatacttac aattacgaat ggcacgtcga      780

tgtctggggc caaggactcc tggtcaccgt ctcctcagct agc                        823


<210>  8
<211>  672
<212>  DNA
<213>  artificial sequence

<220>
<223>  BLV1H12 Light Chain

<400>  8
tcacgaattc gcaggccgtc ctgaaccagc caagcagcgt ctccgggtct ctggggcagc       60

gggtctcaat cacctgtagc gggtcttcct ccaatgtcgg caacggctac gtgtcttggt      120

atcagctgat ccctggcagt gccccacgaa ccctgatcta cggcgacaca tccagagctt      180

ctggggtccc cgatcggttc tcagggagca gatccggaaa cacagctact ctgaccatca      240

gctccctgca ggctgaggac gaagcagatt atttctgcgc atctgccgag gactctagtt      300

caaatgccgt gtttggaagc ggcaccacac tgacagtcct ggggcagccc aagagtcccc      360

cttcagtgac tctgttccca ccctctaccg aggaactgaa cggaaacaag gccacactgg      420

tgtgtctgat cagcgacttt taccctggat ccgtcactgt ggtctggaag gcagatggca      480

gcacaattac taggaacgtg gaaactaccc gcgcctccaa gcagtctaat agtaaatacg      540

ccgccagctc ctatctgagc ctgacctcta gtgattggaa gtccaaaggg tcatatagct      600

gcgaagtgac ccatgaaggc tcaaccgtga ctaagactgt gaaaccatcc gagtgctcct      660

aggctagctg gc                                                          672


<210>  9
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV1H 12 ascending stalk region

<400>  9

Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser 
1               5                   10          


<210>  10
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV1H 12 decending stalk region

<400>  10

Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val 
1               5                   10          


<210>  11
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  V2 alternative sequence

<400>  11

Trp Gly Gln Gly Leu Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  12
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  V1 Alternative B sequence of VH4-34_Q5RQ6E

<400>  12

Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95  


<210>  13
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  V1 Alternative B sequence of VH4-34_CDR1-G31DY32K_Q5RQ6E

<400>  13

Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95  


<210>  14
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  V1 Alternative B sequence of VH4-34_CDR2-E50S_Q5RQ6E

<400>  14

Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95  


<210>  15
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthesized: V1 Alternative B sequence of 
       VH4-34_CDR1-G31DY32K_CDR2-E50S_Q5RQ6E

<400>  15

Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Lys 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95  


<210>  16
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthesized: V1 Alternative B sequence of VH4-34_CDR1-Cow_Q5RQ6E

<400>  16

Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys 
            20                  25                  30          


Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95  


<210>  17
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthesized: V1 Alternative B sequence of VH4-34_CDR2-Cow_Q5RQ6E

<400>  17

Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Leu Gly Ser Ile Asp 
            20                  25                  30          


Thr Gly Gly Asn Thr Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp Ile 
        35                  40                  45              


Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95  


<210>  18
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthesized: V1 Alternative B sequence of 
       VH4-34_CDR1-Cow_CDR2-E50S_Q5RQ6E

<400>  18

Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys 
            20                  25                  30          


Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95  


<210>  19
<211>  95
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthesized: V1 Alternative N sequence of 
       VH4-34_CDR1-Cow_CDR2-Cow_Q5RQ6E

<400>  19

Gln Val Gln Leu Arg Glu Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys 
            20                  25                  30          


Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95  


<210>  20
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  V2 alternative sequence

<400>  20

Trp Gly His Gly Thr Ala Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  V2 alternative sequence

<400>  21

Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  V2 alternative sequence

<400>  22

Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  23
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  V2 alternative sequence

<400>  23

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  V2 alternative sequence

<400>  24

Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  25
<211>  61
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthesized: ultralong CDR3 sequence (BLV1H12)

<400>  25

Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Cys Pro Asp Gly Tyr 
1               5                   10                  15      


Arg Glu Arg Ser Asp Cys Ser Asn Arg Pro Ala Cys Gly Thr Ser Asp 
            20                  25                  30          


Cys Cys Arg Val Ser Val Phe Gly Asn Cys Leu Thr Thr Leu Pro Val 
        35                  40                  45              


Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp 
    50                  55                  60      


<210>  26
<211>  274
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV1H12 Heavy Chain

<400>  26

Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Ser Ile Asp Thr Gly Gly Asn Thr Gly Tyr Asn Pro Gly Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Ser Val His Gln Glu Thr Lys Lys Tyr Gln Ser Cys Pro Asp Gly Tyr 
            100                 105                 110         


Arg Glu Arg Ser Asp Cys Ser Asn Arg Pro Ala Cys Gly Thr Ser Asp 
        115                 120                 125             


Cys Cys Arg Val Ser Val Phe Gly Asn Cys Leu Thr Thr Leu Pro Val 
    130                 135                 140                 


Ser Tyr Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp Gly 
145                 150                 155                 160 


Gln Gly Leu Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys 
                165                 170                 175     


Val Tyr Pro Leu Ser Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val 
            180                 185                 190         


Thr Leu Gly Cys Leu Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val 
        195                 200                 205             


Thr Trp Asn Ser Gly Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala 
    210                 215                 220                 


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
225                 230                 235                 240 


Pro Gly Ser Thr Ser Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro 
                245                 250                 255     


Ala Ser Ser Thr Lys Val Asp Lys Ala Val Glu Pro Lys Ser Cys Asp 
            260                 265                 270         


Gly Ser 
        


<210>  27
<211>  216
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV1H12 Light Chain

<400>  27

Gln Ala Val Leu Asn Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Asn Gly 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Leu Ile Pro Gly Ser Ala Pro Arg Thr Leu 
        35                  40                  45              


Ile Tyr Gly Asp Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ser Ala Glu Asp Ser Ser 
                85                  90                  95      


Ser Asn Ala Val Phe Gly Ser Gly Thr Thr Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Pro Pro Ser Val Thr Leu Phe Pro Pro Ser Thr Glu Glu 
        115                 120                 125             


Leu Asn Gly Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ser Val Thr Val Val Trp Lys Ala Asp Gly Ser Thr Ile Thr 
145                 150                 155                 160 


Arg Asn Val Glu Thr Thr Arg Ala Ser Lys Gln Ser Asn Ser Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Ser Ser Asp Trp Lys Ser Lys 
            180                 185                 190         


Gly Ser Tyr Ser Cys Glu Val Thr His Glu Gly Ser Thr Val Thr Lys 
        195                 200                 205             


Thr Val Lys Pro Ser Glu Cys Ser 
    210                 215     


<210>  28
<211>  269
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV5B8 heavy chain

<400>  28

Gln Val Gln Leu Arg Glu Ser Gly Pro Ser Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Phe Ser Leu Ser Asp Lys 
            20                  25                  30          


Ala Val Gly Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Ser Ile Asp Thr Gly Gly Ser Thr Gly Tyr Asn Pro Gly Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Ser Val Ser Ser Val Thr Thr Glu Asp Ser Ala Thr Tyr Tyr Cys Thr 
                85                  90                  95      


Thr Val His Gln Glu Thr Arg Lys Thr Cys Ser Asp Gly Tyr Ile Ala 
            100                 105                 110         


Val Asp Ser Cys Gly Arg Gly Gln Ser Asp Gly Cys Val Asn Asp Cys 
        115                 120                 125             


Asn Ser Cys Tyr Tyr Gly Trp Arg Asn Cys Arg Arg Gln Pro Ala Ile 
    130                 135                 140                 


His Ser Tyr Glu Phe His Val Asp Ala Trp Gly Arg Gly Leu Leu Val 
145                 150                 155                 160 


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Lys Val Tyr Pro Leu Ser 
                165                 170                 175     


Ser Cys Cys Gly Asp Lys Ser Ser Ser Thr Val Thr Leu Gly Cys Leu 
            180                 185                 190         


Val Ser Ser Tyr Met Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
        195                 200                 205             


Ala Leu Lys Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
    210                 215                 220                 


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Gly Ser Thr Ser 
225                 230                 235                 240 


Gly Gln Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
                245                 250                 255     


Val Asp Lys Ala Val Glu Pro Lys Ser Cys Asp Gly Ser 
            260                 265                 


<210>  29
<211>  216
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV5B8 light chain

<400>  29

Gln Ala Val Leu Asn Gln Pro Ser Ser Val Ser Gly Ser Leu Gly Gln 
1               5                   10                  15      


Arg Val Ser Ile Thr Cys Ser Gly Ser Ser Ser Asn Val Gly Asn Gly 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Leu Ile Pro Gly Ser Ala Pro Arg Thr Leu 
        35                  40                  45              


Ile Tyr Gly Asp Thr Ser Arg Ala Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Phe Cys Ala Ser Ala Glu Asp Ser Ser 
                85                  90                  95      


Ser Asn Ala Val Phe Gly Ser Gly Thr Thr Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ser Pro Pro Ser Val Thr Leu Phe Pro Pro Ser Thr Glu Glu 
        115                 120                 125             


Leu Asn Gly Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ser Val Thr Val Val Trp Lys Ala Asp Gly Ser Thr Ile Thr 
145                 150                 155                 160 


Arg Asn Val Glu Thr Thr Arg Ala Ser Lys Gln Ser Asn Ser Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Ser Ser Asp Trp Lys Ser Lys 
            180                 185                 190         


Gly Ser Tyr Ser Cys Glu Val Thr His Glu Gly Ser Thr Val Thr Lys 
        195                 200                 205             


Thr Val Lys Pro Ser Glu Cys Ser 
    210                 215     


<210>  30
<211>  56
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV5B8 CDR3

<400>  30

Thr Val His Gln Glu Thr Arg Lys Thr Cys Ser Asp Gly Tyr Ile Ala 
1               5                   10                  15      


Val Asp Ser Cys Gly Arg Gly Gln Ser Asp Gly Cys Val Asn Asp Cys 
            20                  25                  30          


Asn Ser Cys Tyr Tyr Gly Trp Arg Asn Cys Arg Arg Gln Pro Ala Ile 
        35                  40                  45              


His Ser Tyr Glu Phe His Val Asp 
    50                  55      


<210>  31
<211>  57
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV5D3 CDR3

<400>  31

Ser Val Thr Gln Arg Thr His Val Ser Arg Ser Cys Pro Asp Gly Cys 
1               5                   10                  15      


Ser Asp Gly Asp Gly Cys Val Asp Gly Cys Cys Cys Ser Ala Tyr Arg 
            20                  25                  30          


Cys Tyr Thr Pro Gly Val Arg Asp Leu Ser Cys Thr Ser Tyr Ser Ile 
        35                  40                  45              


Thr Tyr Thr Tyr Glu Trp Asn Val Asp 
    50                  55          


<210>  32
<211>  58
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV8C11 CDR3

<400>  32

Thr Val His Gln Lys Thr Thr Arg Lys Thr Cys Cys Ser Asp Ala Tyr 
1               5                   10                  15      


Arg Tyr Asp Ser Gly Cys Gly Ser Gly Cys Asp Cys Cys Gly Ala Asp 
            20                  25                  30          


Cys Tyr Val Phe Gly Ala Cys Thr Phe Gly Leu Asp Ser Ser Tyr Ser 
        35                  40                  45              


Tyr Ile Tyr Ile Tyr Gln Trp Tyr Val Asp 
    50                  55              


<210>  33
<211>  56
<212>  PRT
<213>  artificial sequence

<220>
<223>  BF4E9 CDR3

<400>  33

Thr Val His Gln Ile Phe Cys Pro Asp Gly Tyr Ser Tyr Gly Tyr Gly 
1               5                   10                  15      


Cys Gly Tyr Gly Tyr Gly Cys Ser Gly Tyr Asp Cys Tyr Gly Tyr Gly 
            20                  25                  30          


Gly Tyr Gly Tyr Gly Gly Tyr Gly Gly Tyr Ser Ser Tyr Ser Tyr Ser 
        35                  40                  45              


Tyr Ser Tyr Glu Tyr Tyr Gly Asp 
    50                  55      


<210>  34
<211>  48
<212>  PRT
<213>  artificial sequence

<220>
<223>  BF1H1 CDR3

<400>  34

Thr Val His Pro Ser Pro Asp Gly Tyr Ser Tyr Gly Tyr Gly Cys Gly 
1               5                   10                  15      


Tyr Gly Tyr Gly Cys Ser Gly Tyr Asp Cys Tyr Gly Tyr Gly Gly Tyr 
            20                  25                  30          


Gly Tyr Gly Gly Tyr Gly Gly Tyr Ser Ser Tyr Ser Tyr Ser Tyr Ser 
        35                  40                  45              


<210>  35
<211>  48
<212>  PRT
<213>  artificial sequence

<220>
<223>  F18 CDR3

<400>  35

Thr Val His Gln Ile Arg Cys Pro Asp Gly Tyr Gly Tyr Gly Tyr Gly 
1               5                   10                  15      


Cys Gly Tyr Gly Ser Tyr Gly Tyr Ser Gly Tyr Asp Cys Tyr Gly Tyr 
            20                  25                  30          


Gly Gly Tyr Gly Gly Tyr Gly Gly Tyr Gly Gly Tyr Ser Ser Tyr Ser 
        35                  40                  45              


<210>  36
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  36

Thr Thr Val His Gln 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  37

Thr Ser Val His Gln 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  38

Ser Ser Val Thr Gln 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  39

Ser Thr Val His Gln 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  40

Ala Thr Val Arg Gln 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  41

Thr Thr Val Tyr Gln 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  42

Ser Pro Val His Gln 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  43

Ala Thr Val Tyr Gln 
1               5   


<210>  44
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  44

Ala Ser Cys Glu Asn Asp Ile Asn Gly Ser Thr Ala Leu Lys Ser Thr 
1               5                   10                  15      


Arg Ala Asn Asp 
            20  


<210>  45
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  45

Thr Asn Val His Gln 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  46

Ala Thr Val His Gln 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  47

Ser Thr Val Tyr Gln 
1               5   


<210>  48
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  48

Thr Ile Val His Gln 
1               5   


<210>  49
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  49

Ala Ile Val Tyr Gln 
1               5   


<210>  50
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  50

Thr Thr Val Phe Gln 
1               5   


<210>  51
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  51

Ala Ala Val Phe Gln 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  52

Gly Thr Val His Gln 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  53

Ala Ser Val His Gln 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  54

Thr Ala Val Phe Gln 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  55

Ala Thr Val Phe Gln 
1               5   


<210>  56
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  56

Ala Ala Ala His Gln 
1               5   


<210>  57
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  57

Val Trp Tyr Gln 
1               


<210>  58
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  58

Gly Thr Val Phe Gln 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  59

Thr Ala Val His Gln 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  60

Ile Thr Val His Gln 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  61

Ile Thr Ala His Gln 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  62

Val Thr Val His Gln 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  63

Ala Ala Val His Gln 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  64

Gly Thr Val Tyr Gln 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  65

Thr Thr Val Leu Gln 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  66

Thr Thr Thr His Gln 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  67

Thr Thr Asp Tyr Gln 
1               5   


<210>  68
<211>  99
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human heavy chain variable region sequence VH4-39

<400>  68

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg 
            


<210>  69
<211>  96
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human heavy chain variable region sequence 4-59*03

<400>  69

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


<210>  70
<211>  97
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human heavy chain variable region sequence 4-34*02

<400>  70

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  71
<211>  97
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human heavy chain variable region sequence 4-34*09

<400>  71

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  72
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  72

Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln 
1               5                   10      


<210>  73
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  73

Val His Gln Glu Thr Lys Lys Tyr Gln 
1               5                   


<210>  74
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  74

Ile His Ser Tyr Glu Phe 
1               5       


<210>  75
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  75

Ser Tyr Glu Phe 
1               


<210>  76
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  76

Tyr Thr Tyr Asn Tyr Glu 
1               5       


<210>  77
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  77

Tyr Thr Tyr Asn Tyr Glu Trp 
1               5           


<210>  78
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  78

Ser Tyr Thr Tyr Asn Tyr Glu Trp 
1               5               


<210>  79
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  79

Thr Tyr Asn Tyr Glu Trp 
1               5       


<210>  80
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  80

Ser Tyr Thr Tyr 
1               


<210>  81
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  81

Gly Ser Lys His Arg Leu Arg Asp Tyr Phe Leu Tyr Asn Glu 
1               5                   10                  


<210>  82
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  82

Gly Ser Lys His Arg Leu Arg Asp Tyr Phe Leu Tyr Asn 
1               5                   10              


<210>  83
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  83

Gly Ser Lys His Arg Leu Arg Asp Tyr Phe Leu Tyr 
1               5                   10          


<210>  84
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  84

Gly Ser Lys His Arg Leu Arg Asp Tyr Phe Leu 
1               5                   10      


<210>  85
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  85

Gly Ser Lys His Arg Leu Arg Asp Tyr Phe 
1               5                   10  


<210>  86
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  86

Gly Ser Lys His Arg Leu Arg Asp Tyr 
1               5                   


<210>  87
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  87

Gly Ser Lys His Arg Leu Arg Asp 
1               5               


<210>  88
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  88

Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn Tyr 
1               5                   10              


<210>  89
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  89

Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn 
1               5                   10          


<210>  90
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  90

Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr 
1               5                   10      


<210>  91
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  91

Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly 
1               5                   10  


<210>  92
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  92

Glu Ala Gly Gly Pro Asp Tyr Arg Asn 
1               5                   


<210>  93
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  93

Glu Ala Gly Gly Pro Asp Tyr Arg 
1               5               


<210>  94
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  94

Glu Ala Gly Gly Pro Asp Tyr 
1               5           


<210>  95
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  95

Glu Ala Gly Gly Pro Asp 
1               5       


<210>  96
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  96

Glu Ala Gly Gly Pro Ile Trp His Asp Asp Val Lys Tyr 
1               5                   10              


<210>  97
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  97

Glu Ala Gly Gly Pro Ile Trp His Asp Asp Val Lys 
1               5                   10          


<210>  98
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  98

Glu Ala Gly Gly Pro Ile Trp His Asp Asp Val 
1               5                   10      


<210>  99
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  99

Glu Ala Gly Gly Pro Ile Trp His Asp Asp 
1               5                   10  


<210>  100
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  100

Glu Ala Gly Gly Pro Ile Trp His Asp 
1               5                   


<210>  101
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  101

Glu Ala Gly Gly Pro Ile Trp His 
1               5               


<210>  102
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  102

Glu Ala Gly Gly Pro Ile Trp 
1               5           


<210>  103
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  103

Glu Ala Gly Gly Pro Ile 
1               5       


<210>  104
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  104

Gly Thr Asp Tyr Thr Ile Asp Asp Gln Gly Ile 
1               5                   10      


<210>  105
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  105

Gly Thr Asp Tyr Thr Ile Asp Asp Gln Gly 
1               5                   10  


<210>  106
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  106

Gly Thr Asp Tyr Thr Ile Asp Asp Gln 
1               5                   


<210>  107
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  107

Gly Thr Asp Tyr Thr Ile Asp Asp 
1               5               


<210>  108
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  108

Gly Thr Asp Tyr Thr Ile Asp 
1               5           


<210>  109
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  109

Gly Thr Asp Tyr Thr Ile 
1               5       


<210>  110
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  110

Asp Lys Gly Asp Ser Asp Tyr Asp Tyr Asn Leu 
1               5                   10      


<210>  111
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  111

Asp Lys Gly Asp Ser Asp Tyr Asp Tyr Asn 
1               5                   10  


<210>  112
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  112

Asp Lys Gly Asp Ser Asp Tyr Asp Tyr 
1               5                   


<210>  113
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  113

Asp Lys Gly Asp Ser Asp Tyr Asp 
1               5               


<210>  114
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  114

Asp Lys Gly Asp Ser Asp Tyr 
1               5           


<210>  115
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  115

Asp Lys Gly Asp Ser Asp 
1               5       


<210>  116
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  116

Tyr Gly Pro Asn Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp 
1               5                   10                  15      


Val 
    


<210>  117
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  117

Gly Pro Asn Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val 
1               5                   10                  15      


<210>  118
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  118

Pro Asn Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val 
1               5                   10                  15  


<210>  119
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  119

Asn Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val 
1               5                   10                  


<210>  120
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  120

Tyr Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val 
1               5                   10              


<210>  121
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  ASCENDING STALK STRAND

<400>  121

Glu Glu Trp Gly Asp Tyr Leu Ala Thr Leu Asp Val 
1               5                   10          


<210>  122
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  122

Tyr Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10                  15  


<210>  123
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  123

Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10                  


<210>  124
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  124

Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10              


<210>  125
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  125

Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10          


<210>  126
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  126

Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10      


<210>  127
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  127

Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10  


<210>  128
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  128

Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   


<210>  129
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  129

Tyr Asp Phe Asn Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10                  15  


<210>  130
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  130

Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10                  


<210>  131
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  131

Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10              


<210>  132
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  132

Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10          


<210>  133
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  133

Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10      


<210>  134
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  134

Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val 
1               5                   10  


<210>  135
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  135

Gln Gly Ile Arg Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val 
1               5                   10                  15      


<210>  136
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  136

Gly Ile Arg Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  137
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  137

Ile Arg Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  138
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  138

Arg Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val 
1               5                   10              


<210>  139
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  139

Tyr Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val 
1               5                   10          


<210>  140
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  140

Gln Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val 
1               5                   10      


<210>  141
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  141

Gly Ser Gly Thr Phe Trp Tyr Phe Asp Val 
1               5                   10  


<210>  142
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  142

Ser Gly Thr Phe Trp Tyr Phe Asp Val 
1               5                   


<210>  143
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  143

Gly Thr Phe Trp Tyr Phe Asp Val 
1               5               


<210>  144
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  144

Tyr Asn Leu Gly Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly 
1               5                   10              


<210>  145
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  145

Asn Leu Gly Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly 
1               5                   10          


<210>  146
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  146

Leu Gly Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly 
1               5                   10      


<210>  147
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  147

Gly Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly 
1               5                   10  


<210>  148
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  148

Tyr Ser Tyr Phe Tyr Tyr Met Asp Gly 
1               5                   


<210>  149
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  DESCENDING STALK STRAND

<400>  149

Ser Tyr Phe Tyr Tyr Met Asp Gly 
1               5               


<210>  150
<211>  2
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  150

Gly Ser 
1       


<210>  151
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  151

Gly Gly Ser 
1           


<210>  152
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  152

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  153
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  153

Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210>  154
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  154

Gly Gly Gly Gly Ser 
1               5   


<210>  155
<211>  662
<212>  DNA
<213>  artificial sequence

<220>
<223>  human light chain lambda region

<400>  155
tcacgaattc gcaggccgtc ctgaaccagc caagcagcgt ctccgggtct ctggggcagc       60

gggtctcaat cacctgtagc gggtcttcct ccaatgtcgg caacggctac gtgtcttggt      120

atcagctgat ccctggcagt gccccacgaa ccctgatcta cggcgacaca tccagagctt      180

ctggggtccc cgatcggttc tcagggagca gatccggaaa cacagctact ctgaccatca      240

gctccctgca ggctgaggac gaagcagatt atttctgcgc atctgccgag gactctagtt      300

caaatgccgt gtttggaagc ggcaccacac tgacagtcct aggtcagccc aaggctgccc      360

cctcggtcac tctgttcccg ccctcctctg aggagcttca agccaacaag gccacactgg      420

tgtgtctcat aagtgacttc tacccgggag ccgtgacagt ggcctggaag gcagatagca      480

gccccgtcaa ggcgggagtg gagaccacca caccctccaa acaaagcaac aacaagtacg      540

cggccagcag ctatctgagc ctgacgcctg agcagtggaa gtcccacaga agctacagct      600

gccaggtcac gcatgaaggg agcaccgtgg agaagacagt ggcccctaca gaatgttcat      660

aa                                                                     662


<210>  156
<211>  216
<212>  PRT
<213>  artificial sequence

<220>
<223>  human VL1-51

<400>  156

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Ala Glu Asp Ser Ser 
                85                  90                  95      


Ser Asn Ala Val Phe Gly Ser Gly Thr Thr Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  157
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  BLV1H12 ascending stalk region

<400>  157
tgtacttctg tgcaccagga aacaaaaaaa taccaaacc                              39


<210>  158
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV1H12 ascending stalk region

<400>  158

Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Thr 
1               5                   10          


<210>  159
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  BLV1H12 ascending stalk region

<400>  159

Cys Thr Ser Val His Gln Glu Thr Lys Lys Tyr Gln Thr 
1               5                   10              


<210>  160
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  Descending stalk region

<400>  160
tcctatactt acaattacga atggcacgtc gatgtctgg                              39


<210>  161
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Descending stalk region

<400>  161

Ser Tyr Thr Tyr Asn Tyr Glu Trp His Val Asp Val Trp 
1               5                   10              


<210>  162
<211>  117
<212>  DNA
<213>  artificial sequence

<220>
<223>  BLV1H12 knob sequence

<400>  162
tgtccggagg attatactta taatccacgt tgccctcagc agtatggttg gagtgactgt       60

gattgtatgg gcgataggtt tgggggttac tgtcgacagg atggttgtag taattat         117


<210>  163
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Coding sequencing for N-terminal GGS linker

<400>  163
ggtggatca                                                                9


<210>  164
<211>  9
<212>  DNA
<213>  artificial sequence

<220>
<223>  Coding sequence for C-terminal GSG linker

<400>  164
ggttcagga                                                                9


<210>  165
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL2

<400>  165

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  166
<211>  399
<212>  DNA
<213>  artificial sequence

<220>
<223>  IL2 coding sequence

<400>  166
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      360

tggattacct tttgtcaaag catcatctca acactgact                             399


<210>  167
<211>  513
<212>  DNA
<213>  artificial sequence

<220>
<223>  Chimeric ultralong bovine heavy chain sequence

<400>  167
caggtgcagc tgcgggagtc gggccccagc ctgatgaagc cgtcacagac cctctccctc       60

acctgcacgg tctctggatc ttcattgaac gacaagtctg taggctgggt ccgccaggct      120

ccagggaagg cgctgcagtg gctcggtagt gtggacacta gtggaaacac agactataac      180

ccaggcctga aatcccggct cagcatcacc aaggacaact ccaagagccg aatctctctt      240

acagtgactg gcatgacaac tgaagactcg gccacatact actgtacttc tgtgcaccag      300

gaaacaaaaa aataccaaag ttgtccggag gattatactt ataatccacg ttgccctcag      360

cagtatggtt ggagtgactg tgattgtatg ggcgataggt ttgggggtta ctgtcgacag      420

gatggttgta gtaattatag ttatacttac aattacgaat ggcacgtcga tgtctggggc      480

caaggactcc tggtcaccgt ctcctcagct agc                                   513


<210>  168
<211>  651
<212>  DNA
<213>  artificial sequence

<220>
<223>  BLV1H12 Light Chain-

<400>  168
caggccgtcc tgaaccagcc aagcagcgtc tccgggtctc tggggcagcg ggtctcaatc       60

acctgtagcg ggtcttcctc caatgtcggc aacggctacg tgtcttggta tcagctgatc      120

cctggcagtg ccccacgaac cctgatctac ggcgacacat ccagagcttc tggggtcccc      180

gatcggttct cagggagcag atccggaaac acagctactc tgaccatcag ctccctgcag      240

gctgaggacg aagcagatta tttctgcgca tctgccgagg actctagttc aaatgccgtg      300

tttggaagcg gcaccacact gacagtccta ggtcagccca aggctgcccc ctcggtcact      360

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcata a               651


<210>  169
<211>  311
<212>  DNA
<213>  artificial sequence

<220>
<223>  Human heavy chain variable region sequence 4-39

<400>  169
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagacac      300

acagtgaggg g                                                           311


<210>  170
<211>  288
<212>  DNA
<213>  artificial sequence

<220>
<223>  Human heavy chain variable region sequence 4-59*03

<400>  170
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agttactact ggagctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca attctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcg                   288


<210>  171
<211>  291
<212>  DNA
<213>  artificial sequence

<220>
<223>  Human heavy chain variable region sequence 4-34*09

<400>  171
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcacagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120

ccagggaagg gactggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180

ccgtccctca agagtcgagt taccatatca gtagacacgt ctaagaacca gttctccctg      240

aagctgagct ctgtgactgc cgcggacacg gccgtgtatt actgtgcgag a               291


<210>  172
<211>  290
<212>  DNA
<213>  artificial sequence

<220>
<223>  Human heavy chain variable region sequence 4-34*02

<400>  172
caggtgcagc tacaacagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag                 290


<210>  173
<211>  98
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human germline light chain variable region sequence VL1-47

<400>  173

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly 
        


<210>  174
<211>  99
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human germline light chain variable region sequence  VL1-40*1

<400>  174

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly 
            


<210>  175
<211>  98
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human germline light chain variable region sequence VL1-51*01

<400>  175

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala 
        


<210>  176
<211>  99
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human germline light chain variable region sequence VL2-18*02

<400>  176

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Arg Val Ser Trp Tyr Gln Gln Pro Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Phe 
            


<210>  177
<211>  296
<212>  DNA
<213>  artificial sequence

<220>
<223>  Human germline light chain variable region sequence VL1-47

<400>  177
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggtcc          296


<210>  178
<211>  299
<212>  DNA
<213>  artificial sequence

<220>
<223>  Human germline light chain variable region sequence  VL1-40*1

<400>  178
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggttc       299


<210>  179
<211>  296
<212>  DNA
<213>  artificial sequence

<220>
<223>  Human germline light chain variable region sequence VL1-51*01

<400>  179
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc       60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc      120

ccaggaacag cccccaaact cctcatttat gacaataata agcgaccctc agggattcct      180

gaccgattct ctggctccaa gtctggcacg tcagccaccc tgggcatcac cggactccag      240

actggggacg aggccgatta ttactgcgga acatgggata gcagcctgag tgctgg          296


<210>  180
<211>  297
<212>  DNA
<213>  artificial sequence

<220>
<223>  Human germline light chain variable region sequence VL2-18*02

<400>  180
cagtctgccc tgactcagcc tccctccgtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgacgttggt agttataacc gtgtctcctg gtaccagcag      120

cccccaggca cagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtc      180

cctgatcgct tctctgggtc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcagcag cactttc         297


