                         SEQUENCE LISTING

<110>  Gemini Therapeutics Inc.
 
<120>  METHODS FOR TREATING PATIENTS HAVING CFH MUTATIONS WITH 
       CFH-ENCODING VECTORS

<130>  GEM-016WO

<150>  62/925,073
<151>  2019-10-23

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  1381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 1 Codon Optimized Human Factor H Like 1 (FHL1)

<400>  1
gcggccgcca ccatgagact tctagcaaag attatttgcc ttatgttatg ggctatttgt       60

gtagcagaag attgcaatga acttcctcca agaagaaata cagaaattct gacaggttcc      120

tggtctgacc aaacatatcc agaaggcacc caggctatct ataaatgccg ccctggatat      180

agatctcttg gaaatgtaat aatggtatgc aggaagggag aatgggttgc tcttaatcca      240

ttaaggaaat gtcagaaaag gccctgtgga catcctggag atactccttt tggtactttt      300

acccttacag gaggaaatgt gtttgaatat ggtgtaaaag ctgtgtatac atgtaatgag      360

gggtatcaat tgctaggtga gattaattac cgtgaatgtg acacagatgg atggaccaat      420

gatattccta tatgtgaagt tgtgaagtgt ttaccagtga cagcaccaga gaatggaaaa      480

attgtcagta gtgcaatgga accagatcgg gaataccatt ttggacaagc agtacggttt      540

gtatgtaact caggctacaa gattgaagga gatgaagaaa tgcattgttc agacgatggt      600

ttttggagta aagagaaacc aaagtgtgtg gaaatttcat gcaaatcccc agatgttata      660

aatggatctc ctatatctca gaagattatt tataaggaga atgaacgatt tcaatataaa      720

tgtaacatgg gttatgaata cagtgaaaga ggagatgctg tatgcactga atctggatgg      780

cgtccgttgc cttcatgtga agaaaaatca tgtgataatc cttatattcc aaatggtgac      840

tactcacctt taaggattaa acacagaact ggagatgaaa tcacgtacca gtgtagaaat      900

ggtttttatc ctgcaacccg gggaaataca gcaaaatgca caagtactgg ctggatacct      960

gctccgagat gtaccttgaa accttgtgat tatccagaca ttaaacatgg aggtctatat     1020

catgagaata tgcgtagacc atactttcca gtagctgtag gaaaatatta ctcctattac     1080

tgtgatgaac attttgagac tccgtcagga agttactggg atcacattca ttgcacacaa     1140

gatggatggt cgccagcagt accatgcctc agaaaatgtt attttcctta tttggaaaat     1200

ggatataatc aaaattatgg aagaaagttt gtacagggta aatctataga cgttgcctgc     1260

catcctggct acgctcttcc aaaagcgcag accacagtta catgtatgga gaatggctgg     1320

tctcctactc ccagatgcat ccgtgtcagc tttaccctct aataagcttg gatccagatc     1380

t                                                                     1381


<210>  2
<211>  1381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 2-Codon Optimized Human Factor H Like 1 (FHL1)

<400>  2
gcggccgcca ccatgagact gctggctaaa attatctgcc tgatgctgtg ggctatctgc       60

gtcgctgagg attgtaacga gctgcccccc cggagaaata cagagatcct gaccggctct      120

tggagcgacc agacatatcc cgagggcacc caggccatct acaagtgcag gcctggctat      180

cgctctctgg gcaacgtgat catggtgtgc aggaagggag agtgggtggc cctgaatccc      240

ctgaggaagt gccagaagcg cccttgtgga cacccaggcg acacaccctt cggcaccttt      300

acactgaccg gcggcaacgt gttcgagtac ggcgtgaagg ccgtgtatac ctgcaacgag      360

ggctaccagc tgctgggcga gatcaattac agagagtgtg acacagatgg ctggaccaac      420

gatatcccta tctgcgaggt ggtgaagtgt ctgcctgtga ccgccccaga gaatggcaag      480

atcgtgagct ccgccatgga gccagacagg gagtatcact tcggccaggc cgtgcgcttc      540

gtgtgcaact ccggctacaa gatcgagggc gatgaggaga tgcactgtag cgacgatggc      600

ttctggtcca aggagaagcc caagtgcgtg gagatcagct gtaagtcccc tgacgtgatc      660

aatggctctc caatcagcca gaagatcatc tataaggaga acgagaggtt tcagtacaag      720

tgcaatatgg gctacgagta ttctgagagg ggcgatgccg tgtgcacaga gagcggatgg      780

cggcccctgc cttcctgcga ggagaagtct tgtgacaacc cttatatccc aaatggcgat      840

tacagcccac tgcggatcaa gcacagaaca ggcgatgaga tcacctatca gtgccggaac      900

ggcttttacc ccgccacaag aggcaatacc gccaagtgta catccaccgg atggatccca      960

gcaccaagat gcaccctgaa gccctgtgac tatcctgata tcaagcacgg cggcctgtat     1020

cacgagaaca tgagacggcc ctacttccct gtggccgtgg gcaagtacta ttcctactat     1080

tgcgacgagc actttgagac accctccggc tcttactggg accacatcca ctgtacccag     1140

gatggatgga gccccgcagt gccatgcctg aggaagtgtt acttccctta tctggagaat     1200

ggctacaacc agaattatgg ccgcaagttt gtgcagggca agagcatcga tgtggcatgc     1260

cacccaggat acgcactgcc aaaggcacag accacagtga cctgtatgga aaacggctgg     1320

tcccctaccc ctcgctgtat cagagtgtca ttcaccctgt aataagcttg gatccagatc     1380

t                                                                     1381


<210>  3
<211>  1381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 3-Non-Codon Optimized Human Factor H Like 1 (FHL1)

<400>  3
gcggccgcca ccatgagact tctagcaaag attatttgcc ttatgttatg ggctatttgt       60

gtagcagaag attgcaatga acttcctcca agaagaaata cagaaattct gacaggttcc      120

tggtctgacc aaacatatcc agaaggcacc caggctatct ataaatgccg ccctggatat      180

cgaagtcttg gaaatgtaat aatggtatgc aggaagggag aatgggttgc tcttaatcca      240

ttaaggaaat gtcagaaaag gccctgtgga catcctggag atactccttt tggtactttt      300

acccttacag gaggaaatgt gtttgaatat ggtgtaaaag ctgtgtatac atgtaatgag      360

gggtatcaat tgctaggtga gattaattac cgtgaatgtg acacagatgg atggaccaat      420

gatattccta tatgtgaagt tgtgaagtgt ttaccagtga cagcaccaga gaatggaaaa      480

attgtcagta gtgcaatgga accagatcgg gaataccatt ttggacaagc agtacggttt      540

gtatgtaact caggctacaa gattgaagga gatgaagaaa tgcattgttc agacgatggt      600

ttttggagta aagagaaacc aaagtgtgtg gaaatttcat gcaaatcccc agatgttata      660

aatggatctc ctatatctca gaagattatt tataaggaga atgaacgatt tcaatataaa      720

tgtaacatgg gttatgaata cagtgaaaga ggagatgctg tatgcactga atctggatgg      780

cgtccgttgc cttcatgtga agaaaaatca tgtgataatc cttatattcc aaatggtgac      840

tactcacctt taaggattaa acacagaact ggagatgaaa tcacgtacca gtgtagaaat      900

ggtttttatc ctgcaacccg gggaaataca gcaaaatgca caagtactgg ctggatacct      960

gctccgagat gtaccttgaa accttgtgat tatccagaca ttaaacatgg aggtctatat     1020

catgagaata tgcgtagacc atactttcca gtagctgtag gaaaatatta ctcctattac     1080

tgtgatgaac attttgagac tccgtcagga agttactggg atcacattca ttgcacacaa     1140

gatggatggt cgccagcagt accatgcctc agaaaatgtt attttcctta tttggaaaat     1200

ggatataatc aaaattatgg aagaaagttt gtacagggta aatctataga cgttgcctgc     1260

catcctggct acgctcttcc aaaagcgcag accacagtta catgtatgga gaatggctgg     1320

tctcctactc ccagatgcat ccgtgtcagc tttaccctct aataagcttg gatccagatc     1380

t                                                                     1381


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 4: SFTL Sequence

<400>  4

Ser Phe Thr Leu 
1               


<210>  5
<211>  3696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 5-CFH Nucleotide Sequence

<400>  5
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat       60

tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa      120

acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga      180

aatgtaataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt      240

cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga      300

ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg      360

ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata      420

tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt      480

gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca      540

ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa      600

gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct      660

atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt      720

tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct      780

tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta      840

aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct      900

gcaacccggg gaaatacagc aaaatgcaca agtactggct ggatacctgc tccgagatgt      960

accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg     1020

cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat     1080

tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg     1140

ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa     1200

aattatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac     1260

gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc     1320

agatgcatcc gtgtcaaaac atgttccaaa tcaagtatag atattgagaa tgggtttatt     1380

tctgaatctc agtatacata tgccttaaaa gaaaaagcga aatatcaatg caaactagga     1440

tatgtaacag cagatggtga aacatcagga tcaattacat gtgggaaaga tggatggtca     1500

gctcaaccca cgtgcattaa atcttgtgat atcccagtat ttatgaatgc cagaactaaa     1560

aatgacttca catggtttaa gctgaatgac acattggact atgaatgcca tgatggttat     1620

gaaagcaata ctggaagcac cactggttcc atagtgtgtg gttacaatgg ttggtctgat     1680

ttacccatat gttatgaaag agaatgcgaa cttcctaaaa tagatgtaca cttagttcct     1740

gatcgcaaga aagaccagta taaagttgga gaggtgttga aattctcctg caaaccagga     1800

tttacaatag ttggacctaa ttccgttcag tgctaccact ttggattgtc tcctgacctc     1860

ccaatatgta aagagcaagt acaatcatgt ggtccacctc ctgaactcct caatgggaat     1920

gttaaggaaa aaacgaaaga agaatatgga cacagtgaag tggtggaata ttattgcaat     1980

cctagatttc taatgaaggg acctaataaa attcaatgtg ttgatggaga gtggacaact     2040

ttaccagtgt gtattgtgga ggagagtacc tgtggagata tacctgaact tgaacatggc     2100

tgggcccagc tttcttcccc tccttattac tatggagatt cagtggaatt caattgctca     2160

gaatcattta caatgattgg acacagatca attacgtgta ttcatggagt atggacccaa     2220

cttccccagt gtgtggcaat agataaactt aagaagtgca aatcatcaaa tttaattata     2280

cttgaggaac atttaaaaaa caagaaggaa ttcgatcata attctaacat aaggtacaga     2340

tgtagaggaa aagaaggatg gatacacaca gtctgcataa atggaagatg ggatccagaa     2400

gtgaactgct caatggcaca aatacaatta tgcccacctc cacctcagat tcccaattct     2460

cacaatatga caaccacact gaattatcgg gatggagaaa aagtatctgt tctttgccaa     2520

gaaaattatc taattcagga aggagaagaa attacatgca aagatggaag atggcagtca     2580

ataccactct gtgttgaaaa aattccatgt tcacaaccac ctcagataga acacggaacc     2640

attaattcat ccaggtcttc acaagaaagt tatgcacatg ggactaaatt gagttatact     2700

tgtgagggtg gtttcaggat atctgaagaa aatgaaacaa catgctacat gggaaaatgg     2760

agttctccac ctcagtgtga aggccttcct tgtaaatctc cacctgagat ttctcatggt     2820

gttgtagctc acatgtcaga cagttatcag tatggagaag aagttacgta caaatgtttt     2880

gaaggttttg gaattgatgg gcctgcaatt gcaaaatgct taggagaaaa atggtctcac     2940

cctccatcat gcataaaaac agattgtctc agtttaccta gctttgaaaa tgccataccc     3000

atgggagaga agaaggatgt gtataaggcg ggtgagcaag tgacttacac ttgtgcaaca     3060

tattacaaaa tggatggagc cagtaatgta acatgcatta atagcagatg gacaggaagg     3120

ccaacatgca gagacacctc ctgtgtgaat ccgcccacag tacaaaatgc ttatatagtg     3180

tcgagacaga tgagtaaata tccatctggt gagagagtac gttatcaatg taggagccct     3240

tatgaaatgt ttggggatga agaagtgatg tgtttaaatg gaaactggac ggaaccacct     3300

caatgcaaag attctacagg aaaatgtggg ccccctccac ctattgacaa tggggacatt     3360

acttcattcc cgttgtcagt atatgctcca gcttcatcag ttgagtacca atgccagaac     3420

ttgtatcaac ttgagggtaa caagcgaata acatgtagaa atggacaatg gtcagaacca     3480

ccaaaatgct tacatccgtg tgtaatatcc cgagaaatta tggaaaatta taacatagca     3540

ttaaggtgga cagccaaaca gaagctttat tcgagaacag gtgaatcagt tgaatttgtg     3600

tgtaaacggg gatatcgtct ttcatcacgt tctcacacat tgcgaacaac atgttgggat     3660

gggaaactgg agtatccaac ttgtgcaaaa agatag                               3696


<210>  6
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 6-CRALBP Promoter

<400>  6
acgcgttaac tagtaccctg gtggtggtgg tggggggggg ggggtgctct ctcagcaacc       60

ccaccccggg atcttgagga gaaagagggc agagaaaaga gggaatggga ctggcccaga      120

tcccagcccc acagccgggc ttccacatgg ccgagcagga actccagagc aggagcacac      180

aaaggagggc tttgatgcgc ctccagccag gcccaggcct ctcccctctc ccctttctct      240

ctgggtcttc ctttgcccca ctgagggcct cctgtgagcc cgatttaacg gaaactgtgg      300

gcggtgagaa gttccttatg acacactaat cccaacctgc tgaccggacc acgcctccag      360

cggagggaac ctctagagct ccaggacatt caggtaccag gtagccccaa ggaggagctg      420

ccgaccatcg at                                                          432


<210>  7
<211>  7296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 7-Representative CFH AAV vector (with CRALBP Promoter)

<400>  7
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgttaact agtaccctgg tggtggtggt      180

gggggggggg gggtgctctc tcagcaaccc caccccggga tcttgaggag aaagagggca      240

gagaaaagag ggaatgggac tggcccagat cccagcccca cagccgggct tccacatggc      300

cgagcaggaa ctccagagca ggagcacaca aaggagggct ttgatgcgcc tccagccagg      360

cccaggcctc tcccctctcc cctttctctc tgggtcttcc tttgccccac tgagggcctc      420

ctgtgagccc gatttaacgg aaactgtggg cggtgagaag ttccttatga cacactaatc      480

ccaacctgct gaccggacca cgcctccagc ggagggaacc tctagagctc caggacattc      540

aggtaccagg tagccccaag gaggagctgc cgaccatcga tagctgcagg cggccgccgc      600

caccatgaga cttctagcaa agattatttg ccttatgtta tgggctattt gtgtagcaga      660

agattgcaat gaacttcctc caagaagaaa tacagaaatt ctgacaggtt cctggtctga      720

ccaaacatat ccagaaggca cccaggctat ctataaatgc cgccctggat atagatctct      780

tggaaatgta ataatggtat gcaggaaggg agaatgggtt gctcttaatc cattaaggaa      840

atgtcagaaa aggccctgtg gacatcctgg agatactcct tttggtactt ttacccttac      900

aggaggaaat gtgtttgaat atggtgtaaa agctgtgtat acatgtaatg aggggtatca      960

attgctaggt gagattaatt accgtgaatg tgacacagat ggatggacca atgatattcc     1020

tatatgtgaa gttgtgaagt gtttaccagt gacagcacca gagaatggaa aaattgtcag     1080

tagtgcaatg gaaccagatc gggaatacca ttttggacaa gcagtacggt ttgtatgtaa     1140

ctcaggctac aagattgaag gagatgaaga aatgcattgt tcagacgatg gtttttggag     1200

taaagagaaa ccaaagtgtg tggaaatttc atgcaaatcc ccagatgtta taaatggatc     1260

tcctatatct cagaagatta tttataagga gaatgaacga tttcaatata aatgtaacat     1320

gggttatgaa tacagtgaaa gaggagatgc tgtatgcact gaatctggat ggcgtccgtt     1380

gccttcatgt gaagaaaaat catgtgataa tccttatatt ccaaatggtg actactcacc     1440

tttaaggatt aaacacagaa ctggagatga aatcacgtac cagtgtagaa atggttttta     1500

tcctgcaacc cggggaaata cagcaaaatg cacaagtact ggctggatac ctgctccgag     1560

atgtaccttg aaaccttgtg attatccaga cattaaacat ggaggtctat atcatgagaa     1620

tatgcgtaga ccatactttc cagtagctgt aggaaaatat tactcctatt actgtgatga     1680

acattttgag actccgtcag gaagttactg ggatcacatt cattgcacac aagatggatg     1740

gtcgccagca gtaccatgcc tcagaaaatg ttattttcct tatttggaaa atggatataa     1800

tcaaaattat ggaagaaagt ttgtacaggg taaatctata gacgttgcct gccatcctgg     1860

ctacgctctt ccaaaagcgc agaccacagt tacatgtatg gagaatggct ggtctcctac     1920

tcccagatgc atccgtgtca aaacatgttc caaatcaagt atagatattg agaatgggtt     1980

tatttctgaa tctcagtata catatgcctt aaaagaaaaa gcgaaatatc aatgcaaact     2040

aggatatgta acagcagatg gtgaaacatc aggatcaatt acatgtggga aagatggatg     2100

gtcagctcaa cccacgtgca ttaaatcttg tgatatccca gtatttatga atgccagaac     2160

taaaaatgac ttcacatggt ttaagctgaa tgacacattg gactatgaat gccatgatgg     2220

ttatgaaagc aatactggaa gcaccactgg ttccatagtg tgtggttaca atggttggtc     2280

tgatttaccc atatgttatg aaagagaatg cgaacttcct aaaatagatg tacacttagt     2340

tcctgatcgc aagaaagacc agtataaagt tggagaggtg ttgaaattct cctgcaaacc     2400

aggatttaca atagttggac ctaattccgt tcagtgctac cactttggat tgtctcctga     2460

cctcccaata tgtaaagagc aagtacaatc atgtggtcca cctcctgaac tcctcaatgg     2520

gaatgttaag gaaaaaacga aagaagaata tggacacagt gaagtggtgg aatattattg     2580

caatcctaga tttctaatga agggacctaa taaaattcaa tgtgttgatg gagagtggac     2640

aactttacca gtgtgtattg tggaggagag tacctgtgga gatatacctg aacttgaaca     2700

tggctgggcc cagctttctt cccctcctta ttactatgga gattcagtgg aattcaattg     2760

ctcagaatca tttacaatga ttggacacag atcaattacg tgtattcatg gagtatggac     2820

ccaacttccc cagtgtgtgg caatagataa acttaagaag tgcaaatcat caaatttaat     2880

tatacttgag gaacatttaa aaaacaagaa ggaattcgat cataattcta acataaggta     2940

cagatgtaga ggaaaagaag gatggataca cacagtctgc ataaatggaa gatgggatcc     3000

agaagtgaac tgctcaatgg cacaaataca attatgccca cctccacctc agattcccaa     3060

ttctcacaat atgacaacca cactgaatta tcgggatgga gaaaaagtat ctgttctttg     3120

ccaagaaaat tatctaattc aggaaggaga agaaattaca tgcaaagatg gaagatggca     3180

gtcaatacca ctctgtgttg aaaaaattcc atgttcacaa ccacctcaga tagaacacgg     3240

aaccattaat tcatccaggt cttcacaaga aagttatgca catgggacta aattgagtta     3300

tacttgtgag ggtggtttca ggatatctga agaaaatgaa acaacatgct acatgggaaa     3360

atggagttct ccacctcagt gtgaaggcct tccttgtaaa tctccacctg agatttctca     3420

tggtgttgta gctcacatgt cagacagtta tcagtatgga gaagaagtta cgtacaaatg     3480

ttttgaaggt tttggaattg atgggcctgc aattgcaaaa tgcttaggag aaaaatggtc     3540

tcaccctcca tcatgcataa aaacagattg tctcagttta cctagctttg aaaatgccat     3600

acccatggga gagaagaagg atgtgtataa ggcgggtgag caagtgactt acacttgtgc     3660

aacatattac aaaatggatg gagccagtaa tgtaacatgc attaatagca gatggacagg     3720

aaggccaaca tgcagagaca cctcctgtgt gaatccgccc acagtacaaa atgcttatat     3780

agtgtcgaga cagatgagta aatatccatc tggtgagaga gtacgttatc aatgtaggag     3840

cccttatgaa atgtttgggg atgaagaagt gatgtgttta aatggaaact ggacggaacc     3900

acctcaatgc aaagattcta caggaaaatg tgggccccct ccacctattg acaatgggga     3960

cattacttca ttcccgttgt cagtatatgc tccagcttca tcagttgagt accaatgcca     4020

gaacttgtat caacttgagg gtaacaagcg aataacatgt agaaatggac aatggtcaga     4080

accaccaaaa tgcttacatc cgtgtgtaat atcccgagaa attatggaaa attataacat     4140

agcattaagg tggacagcca aacagaagct ttattcgaga acaggtgaat cagttgaatt     4200

tgtgtgtaaa cggggatatc gtctttcatc acgttctcac acattgcgaa caacatgttg     4260

ggatgggaaa ctggagtatc caacttgtgc aaaaagatag ctgtgccttc tagttgccag     4320

ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact     4380

gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt     4440

ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat     4500

gctggggatg cggtgggctc tatgggttaa ctcgagggat cccggaccga gcggccgcag     4560

gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc     4620

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga     4680

gcgcgcagct gcctgcaggg gcgcctgatg cggtattttc tccttacgca tctgtgcggt     4740

atttcacacc gcatacgtca aagcaaccat agtacgcgcc ctgtagcggc gcattaagcg     4800

cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg     4860

ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc     4920

taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa     4980

aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc     5040

ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac     5100

tcaaccctat ctcgggctat tcttttgatt tataagggat tttgccgatt tcggcctatt     5160

ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt     5220

ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc     5280

cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg     5340

cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat     5400

caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca     5460

tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc     5520

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct     5580

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg     5640

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg     5700

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc     5760

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca     5820

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac     5880

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa     5940

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg     6000

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt     6060

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg     6120

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc     6180

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga     6240

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta     6300

ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc     6360

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg     6420

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt     6480

cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa     6540

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     6600

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     6660

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     6720

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     6780

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     6840

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     6900

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     6960

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     7020

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     7080

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     7140

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     7200

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     7260

ggttcctggc cttttgctgg ccttttgctc acatgt                               7296


<210>  8
<211>  226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 8-EF1a Promoter

<400>  8
acgcgttaac tagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg       60

ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt      120

cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt      180

cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacag                     226


<210>  9
<211>  7096
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 9-Representative CFH AAV vector (EF1a promoter)

<400>  9
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgttaact agtgggcaga gcgcacatcg      180

cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg      240

tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt      300

gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt      360

gccgccagaa cacagatcga tagctgcagg cggccgccgc caccatgaga cttctagcaa      420

agattatttg ccttatgtta tgggctattt gtgtagcaga agattgcaat gaacttcctc      480

caagaagaaa tacagaaatt ctgacaggtt cctggtctga ccaaacatat ccagaaggca      540

cccaggctat ctataaatgc cgccctggat atagatctct tggaaatgta ataatggtat      600

gcaggaaggg agaatgggtt gctcttaatc cattaaggaa atgtcagaaa aggccctgtg      660

gacatcctgg agatactcct tttggtactt ttacccttac aggaggaaat gtgtttgaat      720

atggtgtaaa agctgtgtat acatgtaatg aggggtatca attgctaggt gagattaatt      780

accgtgaatg tgacacagat ggatggacca atgatattcc tatatgtgaa gttgtgaagt      840

gtttaccagt gacagcacca gagaatggaa aaattgtcag tagtgcaatg gaaccagatc      900

gggaatacca ttttggacaa gcagtacggt ttgtatgtaa ctcaggctac aagattgaag      960

gagatgaaga aatgcattgt tcagacgatg gtttttggag taaagagaaa ccaaagtgtg     1020

tggaaatttc atgcaaatcc ccagatgtta taaatggatc tcctatatct cagaagatta     1080

tttataagga gaatgaacga tttcaatata aatgtaacat gggttatgaa tacagtgaaa     1140

gaggagatgc tgtatgcact gaatctggat ggcgtccgtt gccttcatgt gaagaaaaat     1200

catgtgataa tccttatatt ccaaatggtg actactcacc tttaaggatt aaacacagaa     1260

ctggagatga aatcacgtac cagtgtagaa atggttttta tcctgcaacc cggggaaata     1320

cagcaaaatg cacaagtact ggctggatac ctgctccgag atgtaccttg aaaccttgtg     1380

attatccaga cattaaacat ggaggtctat atcatgagaa tatgcgtaga ccatactttc     1440

cagtagctgt aggaaaatat tactcctatt actgtgatga acattttgag actccgtcag     1500

gaagttactg ggatcacatt cattgcacac aagatggatg gtcgccagca gtaccatgcc     1560

tcagaaaatg ttattttcct tatttggaaa atggatataa tcaaaattat ggaagaaagt     1620

ttgtacaggg taaatctata gacgttgcct gccatcctgg ctacgctctt ccaaaagcgc     1680

agaccacagt tacatgtatg gagaatggct ggtctcctac tcccagatgc atccgtgtca     1740

aaacatgttc caaatcaagt atagatattg agaatgggtt tatttctgaa tctcagtata     1800

catatgcctt aaaagaaaaa gcgaaatatc aatgcaaact aggatatgta acagcagatg     1860

gtgaaacatc aggatcaatt acatgtggga aagatggatg gtcagctcaa cccacgtgca     1920

ttaaatcttg tgatatccca gtatttatga atgccagaac taaaaatgac ttcacatggt     1980

ttaagctgaa tgacacattg gactatgaat gccatgatgg ttatgaaagc aatactggaa     2040

gcaccactgg ttccatagtg tgtggttaca atggttggtc tgatttaccc atatgttatg     2100

aaagagaatg cgaacttcct aaaatagatg tacacttagt tcctgatcgc aagaaagacc     2160

agtataaagt tggagaggtg ttgaaattct cctgcaaacc aggatttaca atagttggac     2220

ctaattccgt tcagtgctac cactttggat tgtctcctga cctcccaata tgtaaagagc     2280

aagtacaatc atgtggtcca cctcctgaac tcctcaatgg gaatgttaag gaaaaaacga     2340

aagaagaata tggacacagt gaagtggtgg aatattattg caatcctaga tttctaatga     2400

agggacctaa taaaattcaa tgtgttgatg gagagtggac aactttacca gtgtgtattg     2460

tggaggagag tacctgtgga gatatacctg aacttgaaca tggctgggcc cagctttctt     2520

cccctcctta ttactatgga gattcagtgg aattcaattg ctcagaatca tttacaatga     2580

ttggacacag atcaattacg tgtattcatg gagtatggac ccaacttccc cagtgtgtgg     2640

caatagataa acttaagaag tgcaaatcat caaatttaat tatacttgag gaacatttaa     2700

aaaacaagaa ggaattcgat cataattcta acataaggta cagatgtaga ggaaaagaag     2760

gatggataca cacagtctgc ataaatggaa gatgggatcc agaagtgaac tgctcaatgg     2820

cacaaataca attatgccca cctccacctc agattcccaa ttctcacaat atgacaacca     2880

cactgaatta tcgggatgga gaaaaagtat ctgttctttg ccaagaaaat tatctaattc     2940

aggaaggaga agaaattaca tgcaaagatg gaagatggca gtcaatacca ctctgtgttg     3000

aaaaaattcc atgttcacaa ccacctcaga tagaacacgg aaccattaat tcatccaggt     3060

cttcacaaga aagttatgca catgggacta aattgagtta tacttgtgag ggtggtttca     3120

ggatatctga agaaaatgaa acaacatgct acatgggaaa atggagttct ccacctcagt     3180

gtgaaggcct tccttgtaaa tctccacctg agatttctca tggtgttgta gctcacatgt     3240

cagacagtta tcagtatgga gaagaagtta cgtacaaatg ttttgaaggt tttggaattg     3300

atgggcctgc aattgcaaaa tgcttaggag aaaaatggtc tcaccctcca tcatgcataa     3360

aaacagattg tctcagttta cctagctttg aaaatgccat acccatggga gagaagaagg     3420

atgtgtataa ggcgggtgag caagtgactt acacttgtgc aacatattac aaaatggatg     3480

gagccagtaa tgtaacatgc attaatagca gatggacagg aaggccaaca tgcagagaca     3540

cctcctgtgt gaatccgccc acagtacaaa atgcttatat agtgtcgaga cagatgagta     3600

aatatccatc tggtgagaga gtacgttatc aatgtaggag cccttatgaa atgtttgggg     3660

atgaagaagt gatgtgttta aatggaaact ggacggaacc acctcaatgc aaagattcta     3720

caggaaaatg tgggccccct ccacctattg acaatgggga cattacttca ttcccgttgt     3780

cagtatatgc tccagcttca tcagttgagt accaatgcca gaacttgtat caacttgagg     3840

gtaacaagcg aataacatgt agaaatggac aatggtcaga accaccaaaa tgcttacatc     3900

cgtgtgtaat atcccgagaa attatggaaa attataacat agcattaagg tggacagcca     3960

aacagaagct ttattcgaga acaggtgaat cagttgaatt tgtgtgtaaa cggggatatc     4020

gtctttcatc acgttctcac acattgcgaa caacatgttg ggatgggaaa ctggagtatc     4080

caacttgtgc aaaaagatag ctgtgccttc tagttgccag ccatctgttg tttgcccctc     4140

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     4200

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     4260

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc     4320

tatgggttaa ctcgagggat cccggaccga gcggccgcag gaacccctag tgatggagtt     4380

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     4440

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagct gcctgcaggg     4500

gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc gcatacgtca     4560

aagcaaccat agtacgcgcc ctgtagcggc gcattaagcg cggcgggtgt ggtggttacg     4620

cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc tttcttccct     4680

tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg gctcccttta     4740

gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgattt gggtgatggt     4800

tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt ggagtccacg     4860

ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat ctcgggctat     4920

tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa tgagctgatt     4980

taacaaaaat ttaacgcgaa ttttaacaaa atattaacgt ttacaatttt atggtgcact     5040

ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc gccaacaccc     5100

gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc     5160

gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgagacga     5220

aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag     5280

acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa     5340

atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat     5400

tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg     5460

gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa     5520

gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt     5580

gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt     5640

ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat     5700

tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg     5760

acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta     5820

cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat     5880

catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag     5940

cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa     6000

ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca     6060

ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc     6120

ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt     6180

atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc     6240

gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat     6300

atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt     6360

tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac     6420

cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc     6480

ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca     6540

actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta     6600

gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct     6660

ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg     6720

gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc     6780

acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta     6840

tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg     6900

gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt     6960

cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg     7020

cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg     7080

ccttttgctc acatgt                                                     7096


<210>  10
<211>  150
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 10-SV40i Intron

<400>  10
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctaggcc tgtacggaag tgttacttct      120

gctctaaaag ctgcggaatt gtacccgcgg                                       150


<210>  11
<211>  7246
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 11-Representative CFH AAV vector (with EF1a promoter 
       and SV40i intron)

<400>  11
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgttaact agtgggcaga gcgcacatcg      180

cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg      240

tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt tcccgagggt      300

gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg caacgggttt      360

gccgccagaa cacaggtaag tttagtcttt ttgtctttta tttcaggtcc cggatccggt      420

ggtggtgcaa atcaaagaac tgctcctcag tggatgttgc ctttacttct aggcctgtac      480

ggaagtgtta cttctgctct aaaagctgcg gaattgtacc cgcggatcga tagctgcagg      540

cggccgccgc caccatgaga cttctagcaa agattatttg ccttatgtta tgggctattt      600

gtgtagcaga agattgcaat gaacttcctc caagaagaaa tacagaaatt ctgacaggtt      660

cctggtctga ccaaacatat ccagaaggca cccaggctat ctataaatgc cgccctggat      720

atagatctct tggaaatgta ataatggtat gcaggaaggg agaatgggtt gctcttaatc      780

cattaaggaa atgtcagaaa aggccctgtg gacatcctgg agatactcct tttggtactt      840

ttacccttac aggaggaaat gtgtttgaat atggtgtaaa agctgtgtat acatgtaatg      900

aggggtatca attgctaggt gagattaatt accgtgaatg tgacacagat ggatggacca      960

atgatattcc tatatgtgaa gttgtgaagt gtttaccagt gacagcacca gagaatggaa     1020

aaattgtcag tagtgcaatg gaaccagatc gggaatacca ttttggacaa gcagtacggt     1080

ttgtatgtaa ctcaggctac aagattgaag gagatgaaga aatgcattgt tcagacgatg     1140

gtttttggag taaagagaaa ccaaagtgtg tggaaatttc atgcaaatcc ccagatgtta     1200

taaatggatc tcctatatct cagaagatta tttataagga gaatgaacga tttcaatata     1260

aatgtaacat gggttatgaa tacagtgaaa gaggagatgc tgtatgcact gaatctggat     1320

ggcgtccgtt gccttcatgt gaagaaaaat catgtgataa tccttatatt ccaaatggtg     1380

actactcacc tttaaggatt aaacacagaa ctggagatga aatcacgtac cagtgtagaa     1440

atggttttta tcctgcaacc cggggaaata cagcaaaatg cacaagtact ggctggatac     1500

ctgctccgag atgtaccttg aaaccttgtg attatccaga cattaaacat ggaggtctat     1560

atcatgagaa tatgcgtaga ccatactttc cagtagctgt aggaaaatat tactcctatt     1620

actgtgatga acattttgag actccgtcag gaagttactg ggatcacatt cattgcacac     1680

aagatggatg gtcgccagca gtaccatgcc tcagaaaatg ttattttcct tatttggaaa     1740

atggatataa tcaaaattat ggaagaaagt ttgtacaggg taaatctata gacgttgcct     1800

gccatcctgg ctacgctctt ccaaaagcgc agaccacagt tacatgtatg gagaatggct     1860

ggtctcctac tcccagatgc atccgtgtca aaacatgttc caaatcaagt atagatattg     1920

agaatgggtt tatttctgaa tctcagtata catatgcctt aaaagaaaaa gcgaaatatc     1980

aatgcaaact aggatatgta acagcagatg gtgaaacatc aggatcaatt acatgtggga     2040

aagatggatg gtcagctcaa cccacgtgca ttaaatcttg tgatatccca gtatttatga     2100

atgccagaac taaaaatgac ttcacatggt ttaagctgaa tgacacattg gactatgaat     2160

gccatgatgg ttatgaaagc aatactggaa gcaccactgg ttccatagtg tgtggttaca     2220

atggttggtc tgatttaccc atatgttatg aaagagaatg cgaacttcct aaaatagatg     2280

tacacttagt tcctgatcgc aagaaagacc agtataaagt tggagaggtg ttgaaattct     2340

cctgcaaacc aggatttaca atagttggac ctaattccgt tcagtgctac cactttggat     2400

tgtctcctga cctcccaata tgtaaagagc aagtacaatc atgtggtcca cctcctgaac     2460

tcctcaatgg gaatgttaag gaaaaaacga aagaagaata tggacacagt gaagtggtgg     2520

aatattattg caatcctaga tttctaatga agggacctaa taaaattcaa tgtgttgatg     2580

gagagtggac aactttacca gtgtgtattg tggaggagag tacctgtgga gatatacctg     2640

aacttgaaca tggctgggcc cagctttctt cccctcctta ttactatgga gattcagtgg     2700

aattcaattg ctcagaatca tttacaatga ttggacacag atcaattacg tgtattcatg     2760

gagtatggac ccaacttccc cagtgtgtgg caatagataa acttaagaag tgcaaatcat     2820

caaatttaat tatacttgag gaacatttaa aaaacaagaa ggaattcgat cataattcta     2880

acataaggta cagatgtaga ggaaaagaag gatggataca cacagtctgc ataaatggaa     2940

gatgggatcc agaagtgaac tgctcaatgg cacaaataca attatgccca cctccacctc     3000

agattcccaa ttctcacaat atgacaacca cactgaatta tcgggatgga gaaaaagtat     3060

ctgttctttg ccaagaaaat tatctaattc aggaaggaga agaaattaca tgcaaagatg     3120

gaagatggca gtcaatacca ctctgtgttg aaaaaattcc atgttcacaa ccacctcaga     3180

tagaacacgg aaccattaat tcatccaggt cttcacaaga aagttatgca catgggacta     3240

aattgagtta tacttgtgag ggtggtttca ggatatctga agaaaatgaa acaacatgct     3300

acatgggaaa atggagttct ccacctcagt gtgaaggcct tccttgtaaa tctccacctg     3360

agatttctca tggtgttgta gctcacatgt cagacagtta tcagtatgga gaagaagtta     3420

cgtacaaatg ttttgaaggt tttggaattg atgggcctgc aattgcaaaa tgcttaggag     3480

aaaaatggtc tcaccctcca tcatgcataa aaacagattg tctcagttta cctagctttg     3540

aaaatgccat acccatggga gagaagaagg atgtgtataa ggcgggtgag caagtgactt     3600

acacttgtgc aacatattac aaaatggatg gagccagtaa tgtaacatgc attaatagca     3660

gatggacagg aaggccaaca tgcagagaca cctcctgtgt gaatccgccc acagtacaaa     3720

atgcttatat agtgtcgaga cagatgagta aatatccatc tggtgagaga gtacgttatc     3780

aatgtaggag cccttatgaa atgtttgggg atgaagaagt gatgtgttta aatggaaact     3840

ggacggaacc acctcaatgc aaagattcta caggaaaatg tgggccccct ccacctattg     3900

acaatgggga cattacttca ttcccgttgt cagtatatgc tccagcttca tcagttgagt     3960

accaatgcca gaacttgtat caacttgagg gtaacaagcg aataacatgt agaaatggac     4020

aatggtcaga accaccaaaa tgcttacatc cgtgtgtaat atcccgagaa attatggaaa     4080

attataacat agcattaagg tggacagcca aacagaagct ttattcgaga acaggtgaat     4140

cagttgaatt tgtgtgtaaa cggggatatc gtctttcatc acgttctcac acattgcgaa     4200

caacatgttg ggatgggaaa ctggagtatc caacttgtgc aaaaagatag ctgtgccttc     4260

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc     4320

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg     4380

tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa     4440

tagcaggcat gctggggatg cggtgggctc tatgggttaa ctcgagggat cccggaccga     4500

gcggccgcag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     4560

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     4620

gagcgagcga gcgcgcagct gcctgcaggg gcgcctgatg cggtattttc tccttacgca     4680

tctgtgcggt atttcacacc gcatacgtca aagcaaccat agtacgcgcc ctgtagcggc     4740

gcattaagcg cggcgggtgt ggtggttacg cgcagcgtga ccgctacact tgccagcgcc     4800

ctagcgcccg ctcctttcgc tttcttccct tcctttctcg ccacgttcgc cggctttccc     4860

cgtcaagctc taaatcgggg gctcccttta gggttccgat ttagtgcttt acggcacctc     4920

gaccccaaaa aacttgattt gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg     4980

gtttttcgcc ctttgacgtt ggagtccacg ttctttaata gtggactctt gttccaaact     5040

ggaacaacac tcaaccctat ctcgggctat tcttttgatt tataagggat tttgccgatt     5100

tcggcctatt ggttaaaaaa tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa     5160

atattaacgt ttacaatttt atggtgcact ctcagtacaa tctgctctga tgccgcatag     5220

ttaagccagc cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc     5280

ccggcatccg cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt     5340

tcaccgtcat caccgaaacg cgcgagacga aagggcctcg tgatacgcct atttttatag     5400

gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg     5460

cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga     5520

caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat     5580

ttccgtgtcg cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca     5640

gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc     5700

gaactggatc tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca     5760

atgatgagca cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg     5820

caagagcaac tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca     5880

gtcacagaaa agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata     5940

accatgagtg ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag     6000

ctaaccgctt ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg     6060

gagctgaatg aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca     6120

acaacgttgc gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta     6180

atagactgga tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct     6240

ggctggttta ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca     6300

gcactggggc cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag     6360

gcaactatgg atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat     6420

tggtaactgt cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt     6480

taatttaaaa ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa     6540

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     6600

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     6660

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     6720

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     6780

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     6840

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     6900

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     6960

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     7020

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     7080

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     7140

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     7200

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgt                    7246


<210>  12
<211>  476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 12-HSP70 Promoter

<400>  12
actagtcctg cagggccgcc cactccccct tcctctcagg gtccctgtcc cctccagtga       60

atcccagaag actctggaga gttctgagca gggggcggca ctctggcctc tgattggtcc      120

aaggaaggct ggggggcagg acgggaggcg aaaaccctgg aatattcccg acctggcagc      180

ctcatcgagc tcggtgattg gctcagaagg gaaaaggcgg gtctccgtga cgacttataa      240

aagcccaggg gcaagcggtc cggataacgg ctagcctgag gagctgctgc gacagtccac      300

tacctttttc gagagtgact cccgttgtcc caaggcttcc cagagcgaac ctgtgcggct      360

gcaggcaccg gcgcgtcgag tttccggcgt ccggaaggac cgagctcttc tcgcggatcc      420

agtgttccgt ttccagcccc caatctcaga gcggagccga cagagagcag ggaacc          476


<210>  13
<211>  7344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 13-Representative CFH AAV Vector (with HSP70 Promoter)

<400>  13
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgcg ttaactagtc ctgcagggcc gcccactccc      180

ccttcctctc agggtccctg tcccctccag tgaatcccag aagactctgg agagttctga      240

gcagggggcg gcactctggc ctctgattgg tccaaggaag gctggggggc aggacgggag      300

gcgaaaaccc tggaatattc ccgacctggc agcctcatcg agctcggtga ttggctcaga      360

agggaaaagg cgggtctccg tgacgactta taaaagccca ggggcaagcg gtccggataa      420

cggctagcct gaggagctgc tgcgacagtc cactaccttt ttcgagagtg actcccgttg      480

tcccaaggct tcccagagcg aacctgtgcg gctgcaggca ccggcgcgtc gagtttccgg      540

cgtccggaag gaccgagctc ttctcgcgga tccagtgttc cgtttccagc ccccaatctc      600

agagcggagc cgacagagag cagggaaccc tgcagatcga tgcggccgca ccatgagact      660

tctagcaaag attatttgcc ttatgttatg ggctatttgt gtagcagaag attgcaatga      720

acttcctcca agaagaaata cagaaattct gacaggttcc tggtctgacc aaacatatcc      780

agaaggcacc caggctatct ataaatgccg ccctggatat agatctcttg gaaatgtaat      840

aatggtatgc aggaagggag aatgggttgc tcttaatcca ttaaggaaat gtcagaaaag      900

gccctgtgga catcctggag atactccttt tggtactttt acccttacag gaggaaatgt      960

gtttgaatat ggtgtaaaag ctgtgtatac atgtaatgag gggtatcaat tgctaggtga     1020

gattaattac cgtgaatgtg acacagatgg atggaccaat gatattccta tatgtgaagt     1080

tgtgaagtgt ttaccagtga cagcaccaga gaatggaaaa attgtcagta gtgcaatgga     1140

accagatcgg gaataccatt ttggacaagc agtacggttt gtatgtaact caggctacaa     1200

gattgaagga gatgaagaaa tgcattgttc agacgatggt ttttggagta aagagaaacc     1260

aaagtgtgtg gaaatttcat gcaaatcccc agatgttata aatggatctc ctatatctca     1320

gaagattatt tataaggaga atgaacgatt tcaatataaa tgtaacatgg gttatgaata     1380

cagtgaaaga ggagatgctg tatgcactga atctggatgg cgtccgttgc cttcatgtga     1440

agaaaaatca tgtgataatc cttatattcc aaatggtgac tactcacctt taaggattaa     1500

acacagaact ggagatgaaa tcacgtacca gtgtagaaat ggtttttatc ctgcaacccg     1560

gggaaataca gcaaaatgca caagtactgg ctggatacct gctccgagat gtaccttgaa     1620

accttgtgat tatccagaca ttaaacatgg aggtctatat catgagaata tgcgtagacc     1680

atactttcca gtagctgtag gaaaatatta ctcctattac tgtgatgaac attttgagac     1740

tccgtcagga agttactggg atcacattca ttgcacacaa gatggatggt cgccagcagt     1800

accatgcctc agaaaatgtt attttcctta tttggaaaat ggatataatc aaaattatgg     1860

aagaaagttt gtacagggta aatctataga cgttgcctgc catcctggct acgctcttcc     1920

aaaagcgcag accacagtta catgtatgga gaatggctgg tctcctactc ccagatgcat     1980

ccgtgtcaaa acatgttcca aatcaagtat agatattgag aatgggttta tttctgaatc     2040

tcagtataca tatgccttaa aagaaaaagc gaaatatcaa tgcaaactag gatatgtaac     2100

agcagatggt gaaacatcag gatcaattac atgtgggaaa gatggatggt cagctcaacc     2160

cacgtgcatt aaatcttgtg atatcccagt atttatgaat gccagaacta aaaatgactt     2220

cacatggttt aagctgaatg acacattgga ctatgaatgc catgatggtt atgaaagcaa     2280

tactggaagc accactggtt ccatagtgtg tggttacaat ggttggtctg atttacccat     2340

atgttatgaa agagaatgcg aacttcctaa aatagatgta cacttagttc ctgatcgcaa     2400

gaaagaccag tataaagttg gagaggtgtt gaaattctcc tgcaaaccag gatttacaat     2460

agttggacct aattccgttc agtgctacca ctttggattg tctcctgacc tcccaatatg     2520

taaagagcaa gtacaatcat gtggtccacc tcctgaactc ctcaatggga atgttaagga     2580

aaaaacgaaa gaagaatatg gacacagtga agtggtggaa tattattgca atcctagatt     2640

tctaatgaag ggacctaata aaattcaatg tgttgatgga gagtggacaa ctttaccagt     2700

gtgtattgtg gaggagagta cctgtggaga tatacctgaa cttgaacatg gctgggccca     2760

gctttcttcc cctccttatt actatggaga ttcagtggaa ttcaattgct cagaatcatt     2820

tacaatgatt ggacacagat caattacgtg tattcatgga gtatggaccc aacttcccca     2880

gtgtgtggca atagataaac ttaagaagtg caaatcatca aatttaatta tacttgagga     2940

acatttaaaa aacaagaagg aattcgatca taattctaac ataaggtaca gatgtagagg     3000

aaaagaagga tggatacaca cagtctgcat aaatggaaga tgggatccag aagtgaactg     3060

ctcaatggca caaatacaat tatgcccacc tccacctcag attcccaatt ctcacaatat     3120

gacaaccaca ctgaattatc gggatggaga aaaagtatct gttctttgcc aagaaaatta     3180

tctaattcag gaaggagaag aaattacatg caaagatgga agatggcagt caataccact     3240

ctgtgttgaa aaaattccat gttcacaacc acctcagata gaacacggaa ccattaattc     3300

atccaggtct tcacaagaaa gttatgcaca tgggactaaa ttgagttata cttgtgaggg     3360

tggtttcagg atatctgaag aaaatgaaac aacatgctac atgggaaaat ggagttctcc     3420

acctcagtgt gaaggccttc cttgtaaatc tccacctgag atttctcatg gtgttgtagc     3480

tcacatgtca gacagttatc agtatggaga agaagttacg tacaaatgtt ttgaaggttt     3540

tggaattgat gggcctgcaa ttgcaaaatg cttaggagaa aaatggtctc accctccatc     3600

atgcataaaa acagattgtc tcagtttacc tagctttgaa aatgccatac ccatgggaga     3660

gaagaaggat gtgtataagg cgggtgagca agtgacttac acttgtgcaa catattacaa     3720

aatggatgga gccagtaatg taacatgcat taatagcaga tggacaggaa ggccaacatg     3780

cagagacacc tcctgtgtga atccgcccac agtacaaaat gcttatatag tgtcgagaca     3840

gatgagtaaa tatccatctg gtgagagagt acgttatcaa tgtaggagcc cttatgaaat     3900

gtttggggat gaagaagtga tgtgtttaaa tggaaactgg acggaaccac ctcaatgcaa     3960

agattctaca ggaaaatgtg ggccccctcc acctattgac aatggggaca ttacttcatt     4020

cccgttgtca gtatatgctc cagcttcatc agttgagtac caatgccaga acttgtatca     4080

acttgagggt aacaagcgaa taacatgtag aaatggacaa tggtcagaac caccaaaatg     4140

cttacatccg tgtgtaatat cccgagaaat tatggaaaat tataacatag cattaaggtg     4200

gacagccaaa cagaagcttt attcgagaac aggtgaatca gttgaatttg tgtgtaaacg     4260

gggatatcgt ctttcatcac gttctcacac attgcgaaca acatgttggg atgggaaact     4320

ggagtatcca acttgtgcaa aaagatagct gtgccttcta gttgccagcc atctgttgtt     4380

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     4440

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     4500

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg     4560

gtgggctcta tgggttaact cgagggatcc cggaccgagc ggccgcagga acccctagtg     4620

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag     4680

gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc     4740

ctgcaggggc gcctgatgcg gtattttctc cttacgcatc tgtgcggtat ttcacaccgc     4800

atacgtcaaa gcaaccatag tacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg     4860

tggttacgcg cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt     4920

tcttcccttc ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc     4980

tccctttagg gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgatttgg     5040

gtgatggttc acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg     5100

agtccacgtt ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct     5160

cgggctattc ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg     5220

agctgattta acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaattttat     5280

ggtgcactct cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc     5340

caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag     5400

ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg     5460

cgagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg     5520

tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat     5580

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc     5640

aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct     5700

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     5760

atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta     5820

agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc     5880

tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca     5940

tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg     6000

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     6060

ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca     6120

tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa     6180

acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa     6240

ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg gaggcggata     6300

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     6360

ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc     6420

cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata     6480

gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt     6540

actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga     6600

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     6660

cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa     6720

tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag     6780

agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg     6840

tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat     6900

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     6960

ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg     7020

gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc     7080

gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa     7140

gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc     7200

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     7260

caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct     7320

tttgctggcc ttttgctcac atgt                                            7344


<210>  14
<211>  272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 14-sCBA Promoter

<400>  14
actagtcccc acgttctgct tcactctccc catctccccc ccctccccac ccccaatttt       60

gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg ggggggggcg      120

cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga gaggtgcggc      180

ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc ggcggcggcg      240

gcggccctat aaaaagcgaa gcgcgcggcg gg                                    272


<210>  15
<211>  7300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 15-Representative CFH AAV Vector (with sCBA Promoter 
       and SV40i Intron)

<400>  15
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgttaact agtccccacg ttctgcttca      180

ctctccccat ctcccccccc tccccacccc caattttgta tttatttatt ttttaattat      240

tttgtgcagc gatgggggcg gggggggggg gggggcgcgc gccaggcggg gcggggcggg      300

gcgaggggcg gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc      360

tccgaaagtt tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg      420

cgcggcgggg taagtttagt ctttttgtct tttatttcag gtcccggatc cggtggtggt      480

gcaaatcaaa gaactgctcc tcagtggatg ttgcctttac ttctaggcct gtacggaagt      540

gttacttctg ctctaaaagc tgcggaattg tacccgcgga tcgatagctg caggcggccg      600

ccgccaccat gagacttcta gcaaagatta tttgccttat gttatgggct atttgtgtag      660

cagaagattg caatgaactt cctccaagaa gaaatacaga aattctgaca ggttcctggt      720

ctgaccaaac atatccagaa ggcacccagg ctatctataa atgccgccct ggatatagat      780

ctcttggaaa tgtaataatg gtatgcagga agggagaatg ggttgctctt aatccattaa      840

ggaaatgtca gaaaaggccc tgtggacatc ctggagatac tccttttggt acttttaccc      900

ttacaggagg aaatgtgttt gaatatggtg taaaagctgt gtatacatgt aatgaggggt      960

atcaattgct aggtgagatt aattaccgtg aatgtgacac agatggatgg accaatgata     1020

ttcctatatg tgaagttgtg aagtgtttac cagtgacagc accagagaat ggaaaaattg     1080

tcagtagtgc aatggaacca gatcgggaat accattttgg acaagcagta cggtttgtat     1140

gtaactcagg ctacaagatt gaaggagatg aagaaatgca ttgttcagac gatggttttt     1200

ggagtaaaga gaaaccaaag tgtgtggaaa tttcatgcaa atccccagat gttataaatg     1260

gatctcctat atctcagaag attatttata aggagaatga acgatttcaa tataaatgta     1320

acatgggtta tgaatacagt gaaagaggag atgctgtatg cactgaatct ggatggcgtc     1380

cgttgccttc atgtgaagaa aaatcatgtg ataatcctta tattccaaat ggtgactact     1440

cacctttaag gattaaacac agaactggag atgaaatcac gtaccagtgt agaaatggtt     1500

tttatcctgc aacccgggga aatacagcaa aatgcacaag tactggctgg atacctgctc     1560

cgagatgtac cttgaaacct tgtgattatc cagacattaa acatggaggt ctatatcatg     1620

agaatatgcg tagaccatac tttccagtag ctgtaggaaa atattactcc tattactgtg     1680

atgaacattt tgagactccg tcaggaagtt actgggatca cattcattgc acacaagatg     1740

gatggtcgcc agcagtacca tgcctcagaa aatgttattt tccttatttg gaaaatggat     1800

ataatcaaaa ttatggaaga aagtttgtac agggtaaatc tatagacgtt gcctgccatc     1860

ctggctacgc tcttccaaaa gcgcagacca cagttacatg tatggagaat ggctggtctc     1920

ctactcccag atgcatccgt gtcaaaacat gttccaaatc aagtatagat attgagaatg     1980

ggtttatttc tgaatctcag tatacatatg ccttaaaaga aaaagcgaaa tatcaatgca     2040

aactaggata tgtaacagca gatggtgaaa catcaggatc aattacatgt gggaaagatg     2100

gatggtcagc tcaacccacg tgcattaaat cttgtgatat cccagtattt atgaatgcca     2160

gaactaaaaa tgacttcaca tggtttaagc tgaatgacac attggactat gaatgccatg     2220

atggttatga aagcaatact ggaagcacca ctggttccat agtgtgtggt tacaatggtt     2280

ggtctgattt acccatatgt tatgaaagag aatgcgaact tcctaaaata gatgtacact     2340

tagttcctga tcgcaagaaa gaccagtata aagttggaga ggtgttgaaa ttctcctgca     2400

aaccaggatt tacaatagtt ggacctaatt ccgttcagtg ctaccacttt ggattgtctc     2460

ctgacctccc aatatgtaaa gagcaagtac aatcatgtgg tccacctcct gaactcctca     2520

atgggaatgt taaggaaaaa acgaaagaag aatatggaca cagtgaagtg gtggaatatt     2580

attgcaatcc tagatttcta atgaagggac ctaataaaat tcaatgtgtt gatggagagt     2640

ggacaacttt accagtgtgt attgtggagg agagtacctg tggagatata cctgaacttg     2700

aacatggctg ggcccagctt tcttcccctc cttattacta tggagattca gtggaattca     2760

attgctcaga atcatttaca atgattggac acagatcaat tacgtgtatt catggagtat     2820

ggacccaact tccccagtgt gtggcaatag ataaacttaa gaagtgcaaa tcatcaaatt     2880

taattatact tgaggaacat ttaaaaaaca agaaggaatt cgatcataat tctaacataa     2940

ggtacagatg tagaggaaaa gaaggatgga tacacacagt ctgcataaat ggaagatggg     3000

atccagaagt gaactgctca atggcacaaa tacaattatg cccacctcca cctcagattc     3060

ccaattctca caatatgaca accacactga attatcggga tggagaaaaa gtatctgttc     3120

tttgccaaga aaattatcta attcaggaag gagaagaaat tacatgcaaa gatggaagat     3180

ggcagtcaat accactctgt gttgaaaaaa ttccatgttc acaaccacct cagatagaac     3240

acggaaccat taattcatcc aggtcttcac aagaaagtta tgcacatggg actaaattga     3300

gttatacttg tgagggtggt ttcaggatat ctgaagaaaa tgaaacaaca tgctacatgg     3360

gaaaatggag ttctccacct cagtgtgaag gccttccttg taaatctcca cctgagattt     3420

ctcatggtgt tgtagctcac atgtcagaca gttatcagta tggagaagaa gttacgtaca     3480

aatgttttga aggttttgga attgatgggc ctgcaattgc aaaatgctta ggagaaaaat     3540

ggtctcaccc tccatcatgc ataaaaacag attgtctcag tttacctagc tttgaaaatg     3600

ccatacccat gggagagaag aaggatgtgt ataaggcggg tgagcaagtg acttacactt     3660

gtgcaacata ttacaaaatg gatggagcca gtaatgtaac atgcattaat agcagatgga     3720

caggaaggcc aacatgcaga gacacctcct gtgtgaatcc gcccacagta caaaatgctt     3780

atatagtgtc gagacagatg agtaaatatc catctggtga gagagtacgt tatcaatgta     3840

ggagccctta tgaaatgttt ggggatgaag aagtgatgtg tttaaatgga aactggacgg     3900

aaccacctca atgcaaagat tctacaggaa aatgtgggcc ccctccacct attgacaatg     3960

gggacattac ttcattcccg ttgtcagtat atgctccagc ttcatcagtt gagtaccaat     4020

gccagaactt gtatcaactt gagggtaaca agcgaataac atgtagaaat ggacaatggt     4080

cagaaccacc aaaatgctta catccgtgtg taatatcccg agaaattatg gaaaattata     4140

acatagcatt aaggtggaca gccaaacaga agctttattc gagaacaggt gaatcagttg     4200

aatttgtgtg taaacgggga tatcgtcttt catcacgttc tcacacattg cgaacaacat     4260

gttgggatgg gaaactggag tatccaactt gtgcaaaaag atagctgtgc cttctagttg     4320

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     4380

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     4440

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     4500

gcatgctggg gatgcggtgg gctctatggg ttaactcgag ggatcccgga ccgagcggcc     4560

gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     4620

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga     4680

gcgagcgcgc agctgcctgc aggggcgcct gatgcggtat tttctcctta cgcatctgtg     4740

cggtatttca caccgcatac gtcaaagcaa ccatagtacg cgccctgtag cggcgcatta     4800

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     4860

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     4920

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     4980

aaaaaacttg atttgggtga tggttcacgt agtgggccat cgccctgata gacggttttt     5040

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     5100

acactcaacc ctatctcggg ctattctttt gatttataag ggattttgcc gatttcggcc     5160

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta     5220

acgtttacaa ttttatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc     5280

cagccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca     5340

tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg     5400

tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat     5460

gtcatgataa taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga     5520

acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa     5580

ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt     5640

gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg     5700

ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg     5760

gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg     5820

agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag     5880

caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca     5940

gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg     6000

agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc     6060

gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg     6120

aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg     6180

ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca attaatagac     6240

tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg     6300

tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg     6360

gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact     6420

atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa     6480

ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca tttttaattt     6540

aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag     6600

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     6660

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     6720

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     6780

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct     6840

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     6900

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     6960

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     7020

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     7080

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     7140

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     7200

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     7260

ttacggttcc tggccttttg ctggcctttt gctcacatgt                           7300


<210>  16
<211>  353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 16-hAAT1 Promoter

<400>  16
gttaacggct gcccactggg catttcatag gtggctcagt cctcttccct ctgcagctgg       60

ccccagaaac ctgccagtta ttggtgccag gtctgtgcca ggagggcgag gcctgtcatt      120

tctagtaatc ctctgggcag tgtgactgta cctcttgcgg caactcaaag ggagagggtg      180

acttgtcccg ggtcacagag ctgaaagggc aggtacaaca ggtgacatgc cgggctgtct      240

gagtttatga gggcccagtc ttgtgtctgc cgggcaatga gcaaggctcc ttcctgtcca      300

agctccccgc ccctccccag cctactgcct ccacccgaag tctacttcct ggg             353


<210>  17
<211>  7229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 17-Representative CFH AAV Vector (with hAAT1 promoter)

<400>  17
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtgttaa cggctgccca ctgggcattt      180

cataggtggc tcagtcctct tccctctgca gctggcccca gaaacctgcc agttattggt      240

gccaggtctg tgccaggagg gcgaggcctg tcatttctag taatcctctg ggcagtgtga      300

ctgtacctct tgcggcaact caaagggaga gggtgacttg tcccgggtca cagagctgaa      360

agggcaggta caacaggtga catgccgggc tgtctgagtt tatgagggcc cagtcttgtg      420

tctgccgggc aatgagcaag gctccttcct gtccaagctc cccgcccctc cccagcctac      480

tgcctccacc cgaagtctac ttcctgggat cgatagctgc aggcggccgc cgccaccatg      540

agacttctag caaagattat ttgccttatg ttatgggcta tttgtgtagc agaagattgc      600

aatgaacttc ctccaagaag aaatacagaa attctgacag gttcctggtc tgaccaaaca      660

tatccagaag gcacccaggc tatctataaa tgccgccctg gatatagatc tcttggaaat      720

gtaataatgg tatgcaggaa gggagaatgg gttgctctta atccattaag gaaatgtcag      780

aaaaggccct gtggacatcc tggagatact ccttttggta cttttaccct tacaggagga      840

aatgtgtttg aatatggtgt aaaagctgtg tatacatgta atgaggggta tcaattgcta      900

ggtgagatta attaccgtga atgtgacaca gatggatgga ccaatgatat tcctatatgt      960

gaagttgtga agtgtttacc agtgacagca ccagagaatg gaaaaattgt cagtagtgca     1020

atggaaccag atcgggaata ccattttgga caagcagtac ggtttgtatg taactcaggc     1080

tacaagattg aaggagatga agaaatgcat tgttcagacg atggtttttg gagtaaagag     1140

aaaccaaagt gtgtggaaat ttcatgcaaa tccccagatg ttataaatgg atctcctata     1200

tctcagaaga ttatttataa ggagaatgaa cgatttcaat ataaatgtaa catgggttat     1260

gaatacagtg aaagaggaga tgctgtatgc actgaatctg gatggcgtcc gttgccttca     1320

tgtgaagaaa aatcatgtga taatccttat attccaaatg gtgactactc acctttaagg     1380

attaaacaca gaactggaga tgaaatcacg taccagtgta gaaatggttt ttatcctgca     1440

acccggggaa atacagcaaa atgcacaagt actggctgga tacctgctcc gagatgtacc     1500

ttgaaacctt gtgattatcc agacattaaa catggaggtc tatatcatga gaatatgcgt     1560

agaccatact ttccagtagc tgtaggaaaa tattactcct attactgtga tgaacatttt     1620

gagactccgt caggaagtta ctgggatcac attcattgca cacaagatgg atggtcgcca     1680

gcagtaccat gcctcagaaa atgttatttt ccttatttgg aaaatggata taatcaaaat     1740

tatggaagaa agtttgtaca gggtaaatct atagacgttg cctgccatcc tggctacgct     1800

cttccaaaag cgcagaccac agttacatgt atggagaatg gctggtctcc tactcccaga     1860

tgcatccgtg tcaaaacatg ttccaaatca agtatagata ttgagaatgg gtttatttct     1920

gaatctcagt atacatatgc cttaaaagaa aaagcgaaat atcaatgcaa actaggatat     1980

gtaacagcag atggtgaaac atcaggatca attacatgtg ggaaagatgg atggtcagct     2040

caacccacgt gcattaaatc ttgtgatatc ccagtattta tgaatgccag aactaaaaat     2100

gacttcacat ggtttaagct gaatgacaca ttggactatg aatgccatga tggttatgaa     2160

agcaatactg gaagcaccac tggttccata gtgtgtggtt acaatggttg gtctgattta     2220

cccatatgtt atgaaagaga atgcgaactt cctaaaatag atgtacactt agttcctgat     2280

cgcaagaaag accagtataa agttggagag gtgttgaaat tctcctgcaa accaggattt     2340

acaatagttg gacctaattc cgttcagtgc taccactttg gattgtctcc tgacctccca     2400

atatgtaaag agcaagtaca atcatgtggt ccacctcctg aactcctcaa tgggaatgtt     2460

aaggaaaaaa cgaaagaaga atatggacac agtgaagtgg tggaatatta ttgcaatcct     2520

agatttctaa tgaagggacc taataaaatt caatgtgttg atggagagtg gacaacttta     2580

ccagtgtgta ttgtggagga gagtacctgt ggagatatac ctgaacttga acatggctgg     2640

gcccagcttt cttcccctcc ttattactat ggagattcag tggaattcaa ttgctcagaa     2700

tcatttacaa tgattggaca cagatcaatt acgtgtattc atggagtatg gacccaactt     2760

ccccagtgtg tggcaataga taaacttaag aagtgcaaat catcaaattt aattatactt     2820

gaggaacatt taaaaaacaa gaaggaattc gatcataatt ctaacataag gtacagatgt     2880

agaggaaaag aaggatggat acacacagtc tgcataaatg gaagatggga tccagaagtg     2940

aactgctcaa tggcacaaat acaattatgc ccacctccac ctcagattcc caattctcac     3000

aatatgacaa ccacactgaa ttatcgggat ggagaaaaag tatctgttct ttgccaagaa     3060

aattatctaa ttcaggaagg agaagaaatt acatgcaaag atggaagatg gcagtcaata     3120

ccactctgtg ttgaaaaaat tccatgttca caaccacctc agatagaaca cggaaccatt     3180

aattcatcca ggtcttcaca agaaagttat gcacatggga ctaaattgag ttatacttgt     3240

gagggtggtt tcaggatatc tgaagaaaat gaaacaacat gctacatggg aaaatggagt     3300

tctccacctc agtgtgaagg ccttccttgt aaatctccac ctgagatttc tcatggtgtt     3360

gtagctcaca tgtcagacag ttatcagtat ggagaagaag ttacgtacaa atgttttgaa     3420

ggttttggaa ttgatgggcc tgcaattgca aaatgcttag gagaaaaatg gtctcaccct     3480

ccatcatgca taaaaacaga ttgtctcagt ttacctagct ttgaaaatgc catacccatg     3540

ggagagaaga aggatgtgta taaggcgggt gagcaagtga cttacacttg tgcaacatat     3600

tacaaaatgg atggagccag taatgtaaca tgcattaata gcagatggac aggaaggcca     3660

acatgcagag acacctcctg tgtgaatccg cccacagtac aaaatgctta tatagtgtcg     3720

agacagatga gtaaatatcc atctggtgag agagtacgtt atcaatgtag gagcccttat     3780

gaaatgtttg gggatgaaga agtgatgtgt ttaaatggaa actggacgga accacctcaa     3840

tgcaaagatt ctacaggaaa atgtgggccc cctccaccta ttgacaatgg ggacattact     3900

tcattcccgt tgtcagtata tgctccagct tcatcagttg agtaccaatg ccagaacttg     3960

tatcaacttg agggtaacaa gcgaataaca tgtagaaatg gacaatggtc agaaccacca     4020

aaatgcttac atccgtgtgt aatatcccga gaaattatgg aaaattataa catagcatta     4080

aggtggacag ccaaacagaa gctttattcg agaacaggtg aatcagttga atttgtgtgt     4140

aaacggggat atcgtctttc atcacgttct cacacattgc gaacaacatg ttgggatggg     4200

aaactggagt atccaacttg tgcaaaaaga tagctgtgcc ttctagttgc cagccatctg     4260

ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc actgtccttt     4320

cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct attctggggg     4380

gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg catgctgggg     4440

atgcggtggg ctctatgggt taactcgagg gatcccggac cgagcggccg caggaacccc     4500

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     4560

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     4620

gctgcctgca ggggcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac     4680

accgcatacg tcaaagcaac catagtacgc gccctgtagc ggcgcattaa gcgcggcggg     4740

tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt     4800

cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg     4860

ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga     4920

tttgggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac     4980

gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc     5040

tatctcgggc tattcttttg atttataagg gattttgccg atttcggcct attggttaaa     5100

aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa cgtttacaat     5160

tttatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca     5220

cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag     5280

acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa     5340

acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat     5400

aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg     5460

tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat     5520

gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat     5580

tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt     5640

aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag     5700

cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa     5760

agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg     5820

ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct     5880

tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac     5940

tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca     6000

caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat     6060

accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact     6120

attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc     6180

ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga     6240

taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg     6300

taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg     6360

aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca     6420

agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta     6480

ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca     6540

ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg     6600

cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga     6660

tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa     6720

tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc     6780

tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg     6840

tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac     6900

ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct     6960

acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc     7020

ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg     7080

gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg     7140

ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct     7200

ggccttttgc tggccttttg ctcacatgt                                       7229


<210>  18
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 18-ALB Promoter

<400>  18
gttaacacgc gttaactagt cagttccaga tggtaaatat acacaaggga tttagtcaaa       60

caattttttg gcaagaatat tatgaatttt gtaatcggtt ggcagccaat gaaatacaaa      120

gatgagtcta gttaataatc tacaattatt ggttaaaga                             159


<210>  19
<211>  7035
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 19-Representative CFH AAV Vector (with ALB Promoter)

<400>  19
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtgttaa cacgcgttaa ctagtcagtt      180

ccagatggta aatatacaca agggatttag tcaaacaatt ttttggcaag aatattatga      240

attttgtaat cggttggcag ccaatgaaat acaaagatga gtctagttaa taatctacaa      300

ttattggtta aagaatcgat agctgcaggc ggccgccgcc accatgagac ttctagcaaa      360

gattatttgc cttatgttat gggctatttg tgtagcagaa gattgcaatg aacttcctcc      420

aagaagaaat acagaaattc tgacaggttc ctggtctgac caaacatatc cagaaggcac      480

ccaggctatc tataaatgcc gccctggata tagatctctt ggaaatgtaa taatggtatg      540

caggaaggga gaatgggttg ctcttaatcc attaaggaaa tgtcagaaaa ggccctgtgg      600

acatcctgga gatactcctt ttggtacttt tacccttaca ggaggaaatg tgtttgaata      660

tggtgtaaaa gctgtgtata catgtaatga ggggtatcaa ttgctaggtg agattaatta      720

ccgtgaatgt gacacagatg gatggaccaa tgatattcct atatgtgaag ttgtgaagtg      780

tttaccagtg acagcaccag agaatggaaa aattgtcagt agtgcaatgg aaccagatcg      840

ggaataccat tttggacaag cagtacggtt tgtatgtaac tcaggctaca agattgaagg      900

agatgaagaa atgcattgtt cagacgatgg tttttggagt aaagagaaac caaagtgtgt      960

ggaaatttca tgcaaatccc cagatgttat aaatggatct cctatatctc agaagattat     1020

ttataaggag aatgaacgat ttcaatataa atgtaacatg ggttatgaat acagtgaaag     1080

aggagatgct gtatgcactg aatctggatg gcgtccgttg ccttcatgtg aagaaaaatc     1140

atgtgataat ccttatattc caaatggtga ctactcacct ttaaggatta aacacagaac     1200

tggagatgaa atcacgtacc agtgtagaaa tggtttttat cctgcaaccc ggggaaatac     1260

agcaaaatgc acaagtactg gctggatacc tgctccgaga tgtaccttga aaccttgtga     1320

ttatccagac attaaacatg gaggtctata tcatgagaat atgcgtagac catactttcc     1380

agtagctgta ggaaaatatt actcctatta ctgtgatgaa cattttgaga ctccgtcagg     1440

aagttactgg gatcacattc attgcacaca agatggatgg tcgccagcag taccatgcct     1500

cagaaaatgt tattttcctt atttggaaaa tggatataat caaaattatg gaagaaagtt     1560

tgtacagggt aaatctatag acgttgcctg ccatcctggc tacgctcttc caaaagcgca     1620

gaccacagtt acatgtatgg agaatggctg gtctcctact cccagatgca tccgtgtcaa     1680

aacatgttcc aaatcaagta tagatattga gaatgggttt atttctgaat ctcagtatac     1740

atatgcctta aaagaaaaag cgaaatatca atgcaaacta ggatatgtaa cagcagatgg     1800

tgaaacatca ggatcaatta catgtgggaa agatggatgg tcagctcaac ccacgtgcat     1860

taaatcttgt gatatcccag tatttatgaa tgccagaact aaaaatgact tcacatggtt     1920

taagctgaat gacacattgg actatgaatg ccatgatggt tatgaaagca atactggaag     1980

caccactggt tccatagtgt gtggttacaa tggttggtct gatttaccca tatgttatga     2040

aagagaatgc gaacttccta aaatagatgt acacttagtt cctgatcgca agaaagacca     2100

gtataaagtt ggagaggtgt tgaaattctc ctgcaaacca ggatttacaa tagttggacc     2160

taattccgtt cagtgctacc actttggatt gtctcctgac ctcccaatat gtaaagagca     2220

agtacaatca tgtggtccac ctcctgaact cctcaatggg aatgttaagg aaaaaacgaa     2280

agaagaatat ggacacagtg aagtggtgga atattattgc aatcctagat ttctaatgaa     2340

gggacctaat aaaattcaat gtgttgatgg agagtggaca actttaccag tgtgtattgt     2400

ggaggagagt acctgtggag atatacctga acttgaacat ggctgggccc agctttcttc     2460

ccctccttat tactatggag attcagtgga attcaattgc tcagaatcat ttacaatgat     2520

tggacacaga tcaattacgt gtattcatgg agtatggacc caacttcccc agtgtgtggc     2580

aatagataaa cttaagaagt gcaaatcatc aaatttaatt atacttgagg aacatttaaa     2640

aaacaagaag gaattcgatc ataattctaa cataaggtac agatgtagag gaaaagaagg     2700

atggatacac acagtctgca taaatggaag atgggatcca gaagtgaact gctcaatggc     2760

acaaatacaa ttatgcccac ctccacctca gattcccaat tctcacaata tgacaaccac     2820

actgaattat cgggatggag aaaaagtatc tgttctttgc caagaaaatt atctaattca     2880

ggaaggagaa gaaattacat gcaaagatgg aagatggcag tcaataccac tctgtgttga     2940

aaaaattcca tgttcacaac cacctcagat agaacacgga accattaatt catccaggtc     3000

ttcacaagaa agttatgcac atgggactaa attgagttat acttgtgagg gtggtttcag     3060

gatatctgaa gaaaatgaaa caacatgcta catgggaaaa tggagttctc cacctcagtg     3120

tgaaggcctt ccttgtaaat ctccacctga gatttctcat ggtgttgtag ctcacatgtc     3180

agacagttat cagtatggag aagaagttac gtacaaatgt tttgaaggtt ttggaattga     3240

tgggcctgca attgcaaaat gcttaggaga aaaatggtct caccctccat catgcataaa     3300

aacagattgt ctcagtttac ctagctttga aaatgccata cccatgggag agaagaagga     3360

tgtgtataag gcgggtgagc aagtgactta cacttgtgca acatattaca aaatggatgg     3420

agccagtaat gtaacatgca ttaatagcag atggacagga aggccaacat gcagagacac     3480

ctcctgtgtg aatccgccca cagtacaaaa tgcttatata gtgtcgagac agatgagtaa     3540

atatccatct ggtgagagag tacgttatca atgtaggagc ccttatgaaa tgtttgggga     3600

tgaagaagtg atgtgtttaa atggaaactg gacggaacca cctcaatgca aagattctac     3660

aggaaaatgt gggccccctc cacctattga caatggggac attacttcat tcccgttgtc     3720

agtatatgct ccagcttcat cagttgagta ccaatgccag aacttgtatc aacttgaggg     3780

taacaagcga ataacatgta gaaatggaca atggtcagaa ccaccaaaat gcttacatcc     3840

gtgtgtaata tcccgagaaa ttatggaaaa ttataacata gcattaaggt ggacagccaa     3900

acagaagctt tattcgagaa caggtgaatc agttgaattt gtgtgtaaac ggggatatcg     3960

tctttcatca cgttctcaca cattgcgaac aacatgttgg gatgggaaac tggagtatcc     4020

aacttgtgca aaaagatagc tgtgccttct agttgccagc catctgttgt ttgcccctcc     4080

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     4140

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     4200

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc ggtgggctct     4260

atgggttaac tcgagggatc ccggaccgag cggccgcagg aacccctagt gatggagttg     4320

gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga     4380

cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagctg cctgcagggg     4440

cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catacgtcaa     4500

agcaaccata gtacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc     4560

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt     4620

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag     4680

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgatttg ggtgatggtt     4740

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt     4800

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcgggctatt     4860

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt     4920

aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttta tggtgcactc     4980

tcagtacaat ctgctctgat gccgcatagt taagccagcc ccgacacccg ccaacacccg     5040

ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg     5100

tctccgggag ctgcatgtgt cagaggtttt caccgtcatc accgaaacgc gcgagacgaa     5160

agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg gtttcttaga     5220

cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta tttttctaaa     5280

tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt caataatatt     5340

gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc ttttttgcgg     5400

cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa gatgctgaag     5460

atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt aagatccttg     5520

agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg     5580

gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc atacactatt     5640

ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg gatggcatga     5700

cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg gccaacttac     5760

ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac atgggggatc     5820

atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca aacgacgagc     5880

gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta actggcgaac     5940

tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat aaagttgcag     6000

gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa tctggagccg     6060

gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag ccctcccgta     6120

tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat agacagatcg     6180

ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt tactcatata     6240

tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg aagatccttt     6300

ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga gcgtcagacc     6360

ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta atctgctgct     6420

tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa gagctaccaa     6480

ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact gtccttctag     6540

tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca tacctcgctc     6600

tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt accgggttgg     6660

actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca     6720

cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag cgtgagctat     6780

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     6840

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     6900

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     6960

ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc ttttgctggc     7020

cttttgctca catgt                                                      7035


<210>  20
<211>  496
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 20-PCK1 Promoter

<400>  20
gttaacagcc cccagttagg ttaggcattt ccaatctttg ccaataagcc acatatttgc       60

ccaagttagg gtgcatcctt cccatgaact ttgactgtga cctttgacta tggggtgaca      120

tcttatagct gtggtgtttt gccaaccagc agctcttggt acacaaaatg tgctgctagc      180

aggtgccccg gccaaccttg tccttgaccc acctgcctgt taagaaaagg gtgttgtgtt      240

ttgcaacagc agtaaaatgg gtcaaggttt agtcagttgg aagttgtgtc aaaactcact      300

atggttggtt gagggctcga agtctcccag cattcattaa caactatctg ttcaatgatt      360

atctccctgg ggcgtgttgc agtgagttgg cccaaagcat aactgaccct ggccgtgatc      420

cagagacctg ccccctgacg tcagtggcga gcctccctgg gtgcagctga ggggcagggc      480

tattcttttc cacagt                                                      496


<210>  21
<211>  7372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 21-Representative CFH AAV Vector (with PCK1Promoter)

<400>  21
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca cgcgtgttaa cagcccccag ttaggttagg      180

catttccaat ctttgccaat aagccacata tttgcccaag ttagggtgca tccttcccat      240

gaactttgac tgtgaccttt gactatgggg tgacatctta tagctgtggt gttttgccaa      300

ccagcagctc ttggtacaca aaatgtgctg ctagcaggtg ccccggccaa ccttgtcctt      360

gacccacctg cctgttaaga aaagggtgtt gtgttttgca acagcagtaa aatgggtcaa      420

ggtttagtca gttggaagtt gtgtcaaaac tcactatggt tggttgaggg ctcgaagtct      480

cccagcattc attaacaact atctgttcaa tgattatctc cctggggcgt gttgcagtga      540

gttggcccaa agcataactg accctggccg tgatccagag acctgccccc tgacgtcagt      600

ggcgagcctc cctgggtgca gctgaggggc agggctattc ttttccacag tatcgatagc      660

tgcaggcggc cgccgccacc atgagacttc tagcaaagat tatttgcctt atgttatggg      720

ctatttgtgt agcagaagat tgcaatgaac ttcctccaag aagaaataca gaaattctga      780

caggttcctg gtctgaccaa acatatccag aaggcaccca ggctatctat aaatgccgcc      840

ctggatatag atctcttgga aatgtaataa tggtatgcag gaagggagaa tgggttgctc      900

ttaatccatt aaggaaatgt cagaaaaggc cctgtggaca tcctggagat actccttttg      960

gtacttttac ccttacagga ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat     1020

gtaatgaggg gtatcaattg ctaggtgaga ttaattaccg tgaatgtgac acagatggat     1080

ggaccaatga tattcctata tgtgaagttg tgaagtgttt accagtgaca gcaccagaga     1140

atggaaaaat tgtcagtagt gcaatggaac cagatcggga ataccatttt ggacaagcag     1200

tacggtttgt atgtaactca ggctacaaga ttgaaggaga tgaagaaatg cattgttcag     1260

acgatggttt ttggagtaaa gagaaaccaa agtgtgtgga aatttcatgc aaatccccag     1320

atgttataaa tggatctcct atatctcaga agattattta taaggagaat gaacgatttc     1380

aatataaatg taacatgggt tatgaataca gtgaaagagg agatgctgta tgcactgaat     1440

ctggatggcg tccgttgcct tcatgtgaag aaaaatcatg tgataatcct tatattccaa     1500

atggtgacta ctcaccttta aggattaaac acagaactgg agatgaaatc acgtaccagt     1560

gtagaaatgg tttttatcct gcaacccggg gaaatacagc aaaatgcaca agtactggct     1620

ggatacctgc tccgagatgt accttgaaac cttgtgatta tccagacatt aaacatggag     1680

gtctatatca tgagaatatg cgtagaccat actttccagt agctgtagga aaatattact     1740

cctattactg tgatgaacat tttgagactc cgtcaggaag ttactgggat cacattcatt     1800

gcacacaaga tggatggtcg ccagcagtac catgcctcag aaaatgttat tttccttatt     1860

tggaaaatgg atataatcaa aattatggaa gaaagtttgt acagggtaaa tctatagacg     1920

ttgcctgcca tcctggctac gctcttccaa aagcgcagac cacagttaca tgtatggaga     1980

atggctggtc tcctactccc agatgcatcc gtgtcaaaac atgttccaaa tcaagtatag     2040

atattgagaa tgggtttatt tctgaatctc agtatacata tgccttaaaa gaaaaagcga     2100

aatatcaatg caaactagga tatgtaacag cagatggtga aacatcagga tcaattacat     2160

gtgggaaaga tggatggtca gctcaaccca cgtgcattaa atcttgtgat atcccagtat     2220

ttatgaatgc cagaactaaa aatgacttca catggtttaa gctgaatgac acattggact     2280

atgaatgcca tgatggttat gaaagcaata ctggaagcac cactggttcc atagtgtgtg     2340

gttacaatgg ttggtctgat ttacccatat gttatgaaag agaatgcgaa cttcctaaaa     2400

tagatgtaca cttagttcct gatcgcaaga aagaccagta taaagttgga gaggtgttga     2460

aattctcctg caaaccagga tttacaatag ttggacctaa ttccgttcag tgctaccact     2520

ttggattgtc tcctgacctc ccaatatgta aagagcaagt acaatcatgt ggtccacctc     2580

ctgaactcct caatgggaat gttaaggaaa aaacgaaaga agaatatgga cacagtgaag     2640

tggtggaata ttattgcaat cctagatttc taatgaaggg acctaataaa attcaatgtg     2700

ttgatggaga gtggacaact ttaccagtgt gtattgtgga ggagagtacc tgtggagata     2760

tacctgaact tgaacatggc tgggcccagc tttcttcccc tccttattac tatggagatt     2820

cagtggaatt caattgctca gaatcattta caatgattgg acacagatca attacgtgta     2880

ttcatggagt atggacccaa cttccccagt gtgtggcaat agataaactt aagaagtgca     2940

aatcatcaaa tttaattata cttgaggaac atttaaaaaa caagaaggaa ttcgatcata     3000

attctaacat aaggtacaga tgtagaggaa aagaaggatg gatacacaca gtctgcataa     3060

atggaagatg ggatccagaa gtgaactgct caatggcaca aatacaatta tgcccacctc     3120

cacctcagat tcccaattct cacaatatga caaccacact gaattatcgg gatggagaaa     3180

aagtatctgt tctttgccaa gaaaattatc taattcagga aggagaagaa attacatgca     3240

aagatggaag atggcagtca ataccactct gtgttgaaaa aattccatgt tcacaaccac     3300

ctcagataga acacggaacc attaattcat ccaggtcttc acaagaaagt tatgcacatg     3360

ggactaaatt gagttatact tgtgagggtg gtttcaggat atctgaagaa aatgaaacaa     3420

catgctacat gggaaaatgg agttctccac ctcagtgtga aggccttcct tgtaaatctc     3480

cacctgagat ttctcatggt gttgtagctc acatgtcaga cagttatcag tatggagaag     3540

aagttacgta caaatgtttt gaaggttttg gaattgatgg gcctgcaatt gcaaaatgct     3600

taggagaaaa atggtctcac cctccatcat gcataaaaac agattgtctc agtttaccta     3660

gctttgaaaa tgccataccc atgggagaga agaaggatgt gtataaggcg ggtgagcaag     3720

tgacttacac ttgtgcaaca tattacaaaa tggatggagc cagtaatgta acatgcatta     3780

atagcagatg gacaggaagg ccaacatgca gagacacctc ctgtgtgaat ccgcccacag     3840

tacaaaatgc ttatatagtg tcgagacaga tgagtaaata tccatctggt gagagagtac     3900

gttatcaatg taggagccct tatgaaatgt ttggggatga agaagtgatg tgtttaaatg     3960

gaaactggac ggaaccacct caatgcaaag attctacagg aaaatgtggg ccccctccac     4020

ctattgacaa tggggacatt acttcattcc cgttgtcagt atatgctcca gcttcatcag     4080

ttgagtacca atgccagaac ttgtatcaac ttgagggtaa caagcgaata acatgtagaa     4140

atggacaatg gtcagaacca ccaaaatgct tacatccgtg tgtaatatcc cgagaaatta     4200

tggaaaatta taacatagca ttaaggtgga cagccaaaca gaagctttat tcgagaacag     4260

gtgaatcagt tgaatttgtg tgtaaacggg gatatcgtct ttcatcacgt tctcacacat     4320

tgcgaacaac atgttgggat gggaaactgg agtatccaac ttgtgcaaaa agatagctgt     4380

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga     4440

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag     4500

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     4560

agacaatagc aggcatgctg gggatgcggt gggctctatg ggttaactcg agggatcccg     4620

gaccgagcgg ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     4680

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     4740

ctcagtgagc gagcgagcgc gcagctgcct gcaggggcgc ctgatgcggt attttctcct     4800

tacgcatctg tgcggtattt cacaccgcat acgtcaaagc aaccatagta cgcgccctgt     4860

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     4920

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     4980

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     5040

cacctcgacc ccaaaaaact tgatttgggt gatggttcac gtagtgggcc atcgccctga     5100

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     5160

caaactggaa caacactcaa ccctatctcg ggctattctt ttgatttata agggattttg     5220

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt     5280

aacaaaatat taacgtttac aattttatgg tgcactctca gtacaatctg ctctgatgcc     5340

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     5400

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     5460

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     5520

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     5580

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     5640

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     5700

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     5760

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     5820

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     5880

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     5940

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     6000

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     6060

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     6120

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     6180

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     6240

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     6300

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     6360

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     6420

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     6480

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     6540

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     6600

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     6660

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     6720

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     6780

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     6840

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     6900

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     6960

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     7020

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     7080

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     7140

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     7200

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     7260

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     7320

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gt             7372


<210>  22
<211>  4681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 22-Representative FHL AAV Vector (with EF1a Promoter)

<400>  22
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccggg gcagagcgca catcgcccac agtccccgag      180

aagttggggg gaggggtcgg caattgaacc ggtgcctaga gaaggtggcg cggggtaaac      240

tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg agaaccgtat      300

ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc cagaacacag      360

accggtctcg aaggcctgca ggcggccgcc gccaccatga atgagacttc tagcaaagat      420

tatttgcctt atgttatggg ctatttgtgt agcagaagat tgcaatgaac ttcctccaag      480

aagaaataca gaaattctga caggttcctg gtctgaccaa acatatccag aaggcaccca      540

ggctatctat aaatgccgcc ctggatatag atctcttgga aatgtaataa tggtatgcag      600

gaagggagaa tgggttgctc ttaatccatt aaggaaatgt cagaaaaggc cctgtggaca      660

tcctggagat actccttttg gtacttttac ccttacagga ggaaatgtgt ttgaatatgg      720

tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg ctaggtgaga ttaattaccg      780

tgaatgtgac acagatggat ggaccaatga tattcctata tgtgaagttg tgaagtgttt      840

accagtgaca gcaccagaga atggaaaaat tgtcagtagt gcaatggaac cagatcggga      900

ataccatttt ggacaagcag tacggtttgt atgtaactca ggctacaaga ttgaaggaga      960

tgaagaaatg cattgttcag acgatggttt ttggagtaaa gagaaaccaa agtgtgtgga     1020

aatttcatgc aaatccccag atgttataaa tggatctcct atatctcaga agattattta     1080

taaggagaat gaacgatttc aatataaatg taacatgggt tatgaataca gtgaaagagg     1140

agatgctgta tgcactgaat ctggatggcg tccgttgcct tcatgtgaag aaaaatcatg     1200

tgataatcct tatattccaa atggtgacta ctcaccttta aggattaaac acagaactgg     1260

agatgaaatc acgtaccagt gtagaaatgg tttttatcct gcaacccggg gaaatacagc     1320

aaaatgcaca agtactggct ggatacctgc tccgagatgt accttgaaac cttgtgatta     1380

tccagacatt aaacatggag gtctatatca tgagaatatg cgtagaccat actttccagt     1440

agctgtagga aaatattact cctattactg tgatgaacat tttgagactc cgtcaggaag     1500

ttactgggat cacattcatt gcacacaaga tggatggtcg ccagcagtac catgcctcag     1560

aaaatgttat tttccttatt tggaaaatgg atataatcaa aatcatggaa gaaagtttgt     1620

acagggtaaa tctatagacg ttgcctgcca tcctggctac gctcttccaa aagcgcagac     1680

cacagttaca tgtatggaga atggctggtc tcctactccc agatgcatcc gtgtcagctt     1740

taccctctga taagatatcg atacattgat gagtttggac aaaccacaac tagaatgcag     1800

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata     1860

agctgcaata aacaagatat cgttaactcg agggatccca cgtgctgatt ttgtaggtaa     1920

ccacgtgcgg accgagcggc cgcaggaacc cctagtgatg gagttggcca ctccctctct     1980

gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc     2040

ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg caggggcgcc tgatgcggta     2100

ttttctcctt acgcatctgt gcggtatttc acaccgcata cgtcaaagca accatagtac     2160

gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct     2220

acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg     2280

ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt     2340

gctttacggc acctcgaccc caaaaaactt gatttgggtg atggttcacg tagtgggcca     2400

tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga     2460

ctcttgttcc aaactggaac aacactcaac cctatctcgg gctattcttt tgatttataa     2520

gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac     2580

gcgaatttta acaaaatatt aacgtttaca attttatggt gcactctcag tacaatctgc     2640

tctgatgccg catagttaag ccagccccga cacccgccaa cacccgctga cgcgccctga     2700

cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc     2760

atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata     2820

cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact     2880

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     2940

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     3000

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     3060

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     3120

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     3180

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     3240

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     3300

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     3360

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     3420

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     3480

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     3540

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     3600

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     3660

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     3720

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     3780

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     3840

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     3900

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     3960

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     4020

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     4080

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     4140

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     4200

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     4260

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     4320

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     4380

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     4440

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     4500

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     4560

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     4620

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     4680

t                                                                     4681


<210>  23
<211>  4607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 23-Representative FHL AAV Vector (with ALB Promoter)

<400>  23
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca gttccagatg gtaaatatac acaagggatt      180

tagtcaaaca attttttggc aagaatatta tgaattttgt aatcggttgg cagccaatga      240

aatacaaaga tgagtctagt taataatcta caattattgg ttaaagaccg gtctcgaagg      300

cctgcaggcg gccgccgcca ccatgaatga gacttctagc aaagattatt tgccttatgt      360

tatgggctat ttgtgtagca gaagattgca atgaacttcc tccaagaaga aatacagaaa      420

ttctgacagg ttcctggtct gaccaaacat atccagaagg cacccaggct atctataaat      480

gccgccctgg atatagatct cttggaaatg taataatggt atgcaggaag ggagaatggg      540

ttgctcttaa tccattaagg aaatgtcaga aaaggccctg tggacatcct ggagatactc      600

cttttggtac ttttaccctt acaggaggaa atgtgtttga atatggtgta aaagctgtgt      660

atacatgtaa tgaggggtat caattgctag gtgagattaa ttaccgtgaa tgtgacacag      720

atggatggac caatgatatt cctatatgtg aagttgtgaa gtgtttacca gtgacagcac      780

cagagaatgg aaaaattgtc agtagtgcaa tggaaccaga tcgggaatac cattttggac      840

aagcagtacg gtttgtatgt aactcaggct acaagattga aggagatgaa gaaatgcatt      900

gttcagacga tggtttttgg agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat      960

ccccagatgt tataaatgga tctcctatat ctcagaagat tatttataag gagaatgaac     1020

gatttcaata taaatgtaac atgggttatg aatacagtga aagaggagat gctgtatgca     1080

ctgaatctgg atggcgtccg ttgccttcat gtgaagaaaa atcatgtgat aatccttata     1140

ttccaaatgg tgactactca cctttaagga ttaaacacag aactggagat gaaatcacgt     1200

accagtgtag aaatggtttt tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta     1260

ctggctggat acctgctccg agatgtacct tgaaaccttg tgattatcca gacattaaac     1320

atggaggtct atatcatgag aatatgcgta gaccatactt tccagtagct gtaggaaaat     1380

attactccta ttactgtgat gaacattttg agactccgtc aggaagttac tgggatcaca     1440

ttcattgcac acaagatgga tggtcgccag cagtaccatg cctcagaaaa tgttattttc     1500

cttatttgga aaatggatat aatcaaaatc atggaagaaa gtttgtacag ggtaaatcta     1560

tagacgttgc ctgccatcct ggctacgctc ttccaaaagc gcagaccaca gttacatgta     1620

tggagaatgg ctggtctcct actcccagat gcatccgtgt cagctttacc ctctgataag     1680

atatcgatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     1740

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     1800

agatatcgtt aactcgaggg atcccacgtg ctgattttgt aggtaaccac gtgcggaccg     1860

agcggccgca ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     1920

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     1980

tgagcgagcg agcgcgcagc tgcctgcagg ggcgcctgat gcggtatttt ctccttacgc     2040

atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg     2100

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     2160

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     2220

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     2280

cgaccccaaa aaacttgatt tgggtgatgg ttcacgtagt gggccatcgc cctgatagac     2340

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac     2400

tggaacaaca ctcaacccta tctcgggcta ttcttttgat ttataaggga ttttgccgat     2460

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa     2520

aatattaacg tttacaattt tatggtgcac tctcagtaca atctgctctg atgccgcata     2580

gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct     2640

cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt     2700

ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata     2760

ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt     2820

gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag     2880

acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca     2940

tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc     3000

agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat     3060

cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc     3120

aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg     3180

gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc     3240

agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat     3300

aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga     3360

gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc     3420

ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc     3480

aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt     3540

aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc     3600

tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc     3660

agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca     3720

ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca     3780

ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt     3840

ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta     3900

acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg     3960

agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc     4020

ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag     4080

cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa     4140

gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc     4200

cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc     4260

gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta     4320

caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag     4380

aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct     4440

tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga     4500

gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc     4560

ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgt                   4607


<210>  24
<211>  4607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 24-Representative FHL AAV Vector (with AAT1 Promoter)

<400>  24
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgca gttccagatg gtaaatatac acaagggatt      180

tagtcaaaca attttttggc aagaatatta tgaattttgt aatcggttgg cagccaatga      240

aatacaaaga tgagtctagt taataatcta caattattgg ttaaagaccg gtctcgaagg      300

cctgcaggcg gccgccgcca ccatgaatga gacttctagc aaagattatt tgccttatgt      360

tatgggctat ttgtgtagca gaagattgca atgaacttcc tccaagaaga aatacagaaa      420

ttctgacagg ttcctggtct gaccaaacat atccagaagg cacccaggct atctataaat      480

gccgccctgg atatagatct cttggaaatg taataatggt atgcaggaag ggagaatggg      540

ttgctcttaa tccattaagg aaatgtcaga aaaggccctg tggacatcct ggagatactc      600

cttttggtac ttttaccctt acaggaggaa atgtgtttga atatggtgta aaagctgtgt      660

atacatgtaa tgaggggtat caattgctag gtgagattaa ttaccgtgaa tgtgacacag      720

atggatggac caatgatatt cctatatgtg aagttgtgaa gtgtttacca gtgacagcac      780

cagagaatgg aaaaattgtc agtagtgcaa tggaaccaga tcgggaatac cattttggac      840

aagcagtacg gtttgtatgt aactcaggct acaagattga aggagatgaa gaaatgcatt      900

gttcagacga tggtttttgg agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat      960

ccccagatgt tataaatgga tctcctatat ctcagaagat tatttataag gagaatgaac     1020

gatttcaata taaatgtaac atgggttatg aatacagtga aagaggagat gctgtatgca     1080

ctgaatctgg atggcgtccg ttgccttcat gtgaagaaaa atcatgtgat aatccttata     1140

ttccaaatgg tgactactca cctttaagga ttaaacacag aactggagat gaaatcacgt     1200

accagtgtag aaatggtttt tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta     1260

ctggctggat acctgctccg agatgtacct tgaaaccttg tgattatcca gacattaaac     1320

atggaggtct atatcatgag aatatgcgta gaccatactt tccagtagct gtaggaaaat     1380

attactccta ttactgtgat gaacattttg agactccgtc aggaagttac tgggatcaca     1440

ttcattgcac acaagatgga tggtcgccag cagtaccatg cctcagaaaa tgttattttc     1500

cttatttgga aaatggatat aatcaaaatc atggaagaaa gtttgtacag ggtaaatcta     1560

tagacgttgc ctgccatcct ggctacgctc ttccaaaagc gcagaccaca gttacatgta     1620

tggagaatgg ctggtctcct actcccagat gcatccgtgt cagctttacc ctctgataag     1680

atatcgatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt     1740

tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca     1800

agatatcgtt aactcgaggg atcccacgtg ctgattttgt aggtaaccac gtgcggaccg     1860

agcggccgca ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     1920

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     1980

tgagcgagcg agcgcgcagc tgcctgcagg ggcgcctgat gcggtatttt ctccttacgc     2040

atctgtgcgg tatttcacac cgcatacgtc aaagcaacca tagtacgcgc cctgtagcgg     2100

cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac ttgccagcgc     2160

cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg ccggctttcc     2220

ccgtcaagct ctaaatcggg ggctcccttt agggttccga tttagtgctt tacggcacct     2280

cgaccccaaa aaacttgatt tgggtgatgg ttcacgtagt gggccatcgc cctgatagac     2340

ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct tgttccaaac     2400

tggaacaaca ctcaacccta tctcgggcta ttcttttgat ttataaggga ttttgccgat     2460

ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga attttaacaa     2520

aatattaacg tttacaattt tatggtgcac tctcagtaca atctgctctg atgccgcata     2580

gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct     2640

cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt     2700

ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata     2760

ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt     2820

gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag     2880

acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca     2940

tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc     3000

agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat     3060

cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc     3120

aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg     3180

gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc     3240

agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat     3300

aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga     3360

gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc     3420

ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc     3480

aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt     3540

aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc     3600

tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc     3660

agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca     3720

ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca     3780

ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt     3840

ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta     3900

acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg     3960

agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc     4020

ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag     4080

cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa     4140

gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc     4200

cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc     4260

gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta     4320

caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag     4380

aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct     4440

tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga     4500

gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc     4560

ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgt                   4607


<210>  25
<211>  4845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 25-Representative FHL AAV Vector (with EF1a.SV40i 
       Promoter)

<400>  25
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgac gcgttaacta gtgggcagag cgcacatcgc      180

ccacagtccc cgagaagttg gggggagggg tcggcaattg aaccggtgcc tagagaaggt      240

ggcgcggggt aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg      300

ggggagaacc gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg      360

ccgccagaac acaggtaagt ttagtctttt tgtcttttat ttcaggtccc ggatccggtg      420

gtggtgcaaa tcaaagaact gctcctcagt ggatgttgcc tttacttcta ggcctgtacg      480

gaagtgttac ttctgctcta aaagctgcgg aattgtaccc gcggaccggt ctcgaaggcc      540

tgcaggcggc cgccgccacc atgaatgaga cttctagcaa agattatttg ccttatgtta      600

tgggctattt gtgtagcaga agattgcaat gaacttcctc caagaagaaa tacagaaatt      660

ctgacaggtt cctggtctga ccaaacatat ccagaaggca cccaggctat ctataaatgc      720

cgccctggat atagatctct tggaaatgta ataatggtat gcaggaaggg agaatgggtt      780

gctcttaatc cattaaggaa atgtcagaaa aggccctgtg gacatcctgg agatactcct      840

tttggtactt ttacccttac aggaggaaat gtgtttgaat atggtgtaaa agctgtgtat      900

acatgtaatg aggggtatca attgctaggt gagattaatt accgtgaatg tgacacagat      960

ggatggacca atgatattcc tatatgtgaa gttgtgaagt gtttaccagt gacagcacca     1020

gagaatggaa aaattgtcag tagtgcaatg gaaccagatc gggaatacca ttttggacaa     1080

gcagtacggt ttgtatgtaa ctcaggctac aagattgaag gagatgaaga aatgcattgt     1140

tcagacgatg gtttttggag taaagagaaa ccaaagtgtg tggaaatttc atgcaaatcc     1200

ccagatgtta taaatggatc tcctatatct cagaagatta tttataagga gaatgaacga     1260

tttcaatata aatgtaacat gggttatgaa tacagtgaaa gaggagatgc tgtatgcact     1320

gaatctggat ggcgtccgtt gccttcatgt gaagaaaaat catgtgataa tccttatatt     1380

ccaaatggtg actactcacc tttaaggatt aaacacagaa ctggagatga aatcacgtac     1440

cagtgtagaa atggttttta tcctgcaacc cggggaaata cagcaaaatg cacaagtact     1500

ggctggatac ctgctccgag atgtaccttg aaaccttgtg attatccaga cattaaacat     1560

ggaggtctat atcatgagaa tatgcgtaga ccatactttc cagtagctgt aggaaaatat     1620

tactcctatt actgtgatga acattttgag actccgtcag gaagttactg ggatcacatt     1680

cattgcacac aagatggatg gtcgccagca gtaccatgcc tcagaaaatg ttattttcct     1740

tatttggaaa atggatataa tcaaaatcat ggaagaaagt ttgtacaggg taaatctata     1800

gacgttgcct gccatcctgg ctacgctctt ccaaaagcgc agaccacagt tacatgtatg     1860

gagaatggct ggtctcctac tcccagatgc atccgtgtca gctttaccct ctgataagat     1920

atcgatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     1980

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     2040

atatcgttaa ctcgagggat cccacgtgct gattttgtag gtaaccacgt gcggaccgag     2100

cggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     2160

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     2220

agcgagcgag cgcgcagctg cctgcagggg cgcctgatgc ggtattttct ccttacgcat     2280

ctgtgcggta tttcacaccg catacgtcaa agcaaccata gtacgcgccc tgtagcggcg     2340

cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc     2400

tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc     2460

gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg     2520

accccaaaaa acttgatttg ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg     2580

tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg     2640

gaacaacact caaccctatc tcgggctatt cttttgattt ataagggatt ttgccgattt     2700

cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa     2760

tattaacgtt tacaatttta tggtgcactc tcagtacaat ctgctctgat gccgcatagt     2820

taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc     2880

cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt     2940

caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg     3000

ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc     3060

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     3120

aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt     3180

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     3240

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     3300

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     3360

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     3420

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     3480

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     3540

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     3600

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     3660

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     3720

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     3780

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     3840

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag     3900

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     3960

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     4020

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt     4080

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     4140

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     4200

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     4260

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     4320

gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga     4380

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     4440

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     4500

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     4560

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa     4620

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     4680

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     4740

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     4800

cctttttacg gttcctggcc ttttgctggc cttttgctca catgt                     4845


<210>  26
<211>  5441
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 26-Representative FHL AAV Vector (with CAG Promoter)

<400>  26
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgtt ggcaaagaat tctgcagtcg acggtaccgc      180

gggcccggga tccaccggtc gccaccatgg tgcgctcctc caagaacgtc atcaaggagt      240

tcatgcgctt caaggtgcgc atggagggca ccgtgaacgg ccacgagttc gagatcgagg      300

gcgagggcga gggccgcccc tacgagggcc acaacaccgt gaagctgaag gtgaccaagg      360

gcggccccct gcccttcgcc tgggacatcc tgtcccccca gttccagtac ggctccaagg      420

tgtacgtgaa gcaccccgcc gacatccccg actacaagaa gctgtccttc cccgagggct      480

tcaagtggga gcgcgtgatg aacttcgagg acggcggcgt ggtgaccgtg acccaggact      540

cctccctgca ggacggctgc ttcatctaca aggtgaagtt catcggcgtg aacttcccct      600

ccgacggccc cgtaatgcag aagaagacca tgggctggga ggcctccacc gagcgcctgt      660

acccccgcga cggcgtgctg aagggcgaga tccacaaggc cctgaagctg aaggacggcg      720

gccactacct ggtggagttc aagtccatct acatggccaa gaagcccgtg cagctgcccg      780

gctactacta cgtggactcc aagctggaca tcacctccca caacgaggac tacaccatcg      840

tggagcagta cgagcgcacc gagggccgcc accacctgtt cctgtagcgg ccgcactcct      900

caggtgcagg ctgcctatca gaaggtggtg gctggtgtgg ccaatgccct ggctcacaaa      960

taccactgag atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     1020

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     1080

ttgtgtctct cactcggaag gacatatggg agggcaaatc accggtctcg aaggcctgca     1140

ggcggccgcc gccaccatga atgagacttc tagcaaagat tatttgcctt atgttatggg     1200

ctatttgtgt agcagaagat tgcaatgaac ttcctccaag aagaaataca gaaattctga     1260

caggttcctg gtctgaccaa acatatccag aaggcaccca ggctatctat aaatgccgcc     1320

ctggatatag atctcttgga aatgtaataa tggtatgcag gaagggagaa tgggttgctc     1380

ttaatccatt aaggaaatgt cagaaaaggc cctgtggaca tcctggagat actccttttg     1440

gtacttttac ccttacagga ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat     1500

gtaatgaggg gtatcaattg ctaggtgaga ttaattaccg tgaatgtgac acagatggat     1560

ggaccaatga tattcctata tgtgaagttg tgaagtgttt accagtgaca gcaccagaga     1620

atggaaaaat tgtcagtagt gcaatggaac cagatcggga ataccatttt ggacaagcag     1680

tacggtttgt atgtaactca ggctacaaga ttgaaggaga tgaagaaatg cattgttcag     1740

acgatggttt ttggagtaaa gagaaaccaa agtgtgtgga aatttcatgc aaatccccag     1800

atgttataaa tggatctcct atatctcaga agattattta taaggagaat gaacgatttc     1860

aatataaatg taacatgggt tatgaataca gtgaaagagg agatgctgta tgcactgaat     1920

ctggatggcg tccgttgcct tcatgtgaag aaaaatcatg tgataatcct tatattccaa     1980

atggtgacta ctcaccttta aggattaaac acagaactgg agatgaaatc acgtaccagt     2040

gtagaaatgg tttttatcct gcaacccggg gaaatacagc aaaatgcaca agtactggct     2100

ggatacctgc tccgagatgt accttgaaac cttgtgatta tccagacatt aaacatggag     2160

gtctatatca tgagaatatg cgtagaccat actttccagt agctgtagga aaatattact     2220

cctattactg tgatgaacat tttgagactc cgtcaggaag ttactgggat cacattcatt     2280

gcacacaaga tggatggtcg ccagcagtac catgcctcag aaaatgttat tttccttatt     2340

tggaaaatgg atataatcaa aatcatggaa gaaagtttgt acagggtaaa tctatagacg     2400

ttgcctgcca tcctggctac gctcttccaa aagcgcagac cacagttaca tgtatggaga     2460

atggctggtc tcctactccc agatgcatcc gtgtcagctt taccctctga taagatatcg     2520

atacattgat gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg     2580

tgaaatttgt gatgctattg ctttatttgt aaccattata agctgcaata aacaagatat     2640

cgttaactcg agggatccca cgtgctgatt ttgtaggtaa ccacgtgcgg accgagcggc     2700

cgcaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     2760

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg     2820

agcgagcgcg cagctgcctg caggggcgcc tgatgcggta ttttctcctt acgcatctgt     2880

gcggtatttc acaccgcata cgtcaaagca accatagtac gcgccctgta gcggcgcatt     2940

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     3000

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     3060

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     3120

caaaaaactt gatttgggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     3180

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     3240

aacactcaac cctatctcgg gctattcttt tgatttataa gggattttgc cgatttcggc     3300

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt     3360

aacgtttaca attttatggt gcactctcag tacaatctgc tctgatgccg catagttaag     3420

ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc     3480

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc     3540

gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa     3600

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg     3660

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata     3720

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg     3780

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac     3840

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact     3900

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat     3960

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga     4020

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac     4080

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat     4140

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac     4200

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct     4260

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac     4320

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga     4380

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg     4440

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact     4500

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac     4560

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta     4620

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt     4680

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga     4740

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc     4800

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt     4860

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc     4920

gcagatacca aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc     4980

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg     5040

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg     5100

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga     5160

actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc     5220

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg     5280

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg     5340

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt     5400

tttacggttc ctggcctttt gctggccttt tgctcacatg t                         5441


<210>  27
<211>  4895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 27-Representative FHL AAV Vector (with CRALBP 
       Promoter)

<400>  27
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgac gcgttaacta gtaccctggt ggtggtggtg      180

gggggggggg ggtgctctct cagcaacccc accccgggat cttgaggaga aagagggcag      240

agaaaagagg gaatgggact ggcccagatc ccagccccac agccgggctt ccacatggcc      300

gagcaggaac tccagagcag gagcacacaa aggagggctt tgatgcgcct ccagccaggc      360

ccaggcctct cccctctccc ctttctctct gggtcttcct ttgccccact gagggcctcc      420

tgtgagcccg atttaacgga aactgtgggc ggtgagaagt tccttatgac acactaatcc      480

caacctgctg accggaccac gcctccagcg gagggaacct ctagagctcc aggacattca      540

ggtaccaggt agccccaagg aggagctgcc gaccaccggt ctcgaaggcc tgcaggcggc      600

cgccgccacc atgaatgaga cttctagcaa agattatttg ccttatgtta tgggctattt      660

gtgtagcaga agattgcaat gaacttcctc caagaagaaa tacagaaatt ctgacaggtt      720

cctggtctga ccaaacatat ccagaaggca cccaggctat ctataaatgc cgccctggat      780

atagatctct tggaaatgta ataatggtat gcaggaaggg agaatgggtt gctcttaatc      840

cattaaggaa atgtcagaaa aggccctgtg gacatcctgg agatactcct tttggtactt      900

ttacccttac aggaggaaat gtgtttgaat atggtgtaaa agctgtgtat acatgtaatg      960

aggggtatca attgctaggt gagattaatt accgtgaatg tgacacagat ggatggacca     1020

atgatattcc tatatgtgaa gttgtgaagt gtttaccagt gacagcacca gagaatggaa     1080

aaattgtcag tagtgcaatg gaaccagatc gggaatacca ttttggacaa gcagtacggt     1140

ttgtatgtaa ctcaggctac aagattgaag gagatgaaga aatgcattgt tcagacgatg     1200

gtttttggag taaagagaaa ccaaagtgtg tggaaatttc atgcaaatcc ccagatgtta     1260

taaatggatc tcctatatct cagaagatta tttataagga gaatgaacga tttcaatata     1320

aatgtaacat gggttatgaa tacagtgaaa gaggagatgc tgtatgcact gaatctggat     1380

ggcgtccgtt gccttcatgt gaagaaaaat catgtgataa tccttatatt ccaaatggtg     1440

actactcacc tttaaggatt aaacacagaa ctggagatga aatcacgtac cagtgtagaa     1500

atggttttta tcctgcaacc cggggaaata cagcaaaatg cacaagtact ggctggatac     1560

ctgctccgag atgtaccttg aaaccttgtg attatccaga cattaaacat ggaggtctat     1620

atcatgagaa tatgcgtaga ccatactttc cagtagctgt aggaaaatat tactcctatt     1680

actgtgatga acattttgag actccgtcag gaagttactg ggatcacatt cattgcacac     1740

aagatggatg gtcgccagca gtaccatgcc tcagaaaatg ttattttcct tatttggaaa     1800

atggatataa tcaaaatcat ggaagaaagt ttgtacaggg taaatctata gacgttgcct     1860

gccatcctgg ctacgctctt ccaaaagcgc agaccacagt tacatgtatg gagaatggct     1920

ggtctcctac tcccagatgc atccgtgtca gctttaccct ctgataagat atcgatacat     1980

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat     2040

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag atatcgttaa     2100

ctcgagggat cccacgtgct gattttgtag gtaaccacgt gcggaccgag cggccgcagg     2160

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg     2220

ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag     2280

cgcgcagctg cctgcagggg cgcctgatgc ggtattttct ccttacgcat ctgtgcggta     2340

tttcacaccg catacgtcaa agcaaccata gtacgcgccc tgtagcggcg cattaagcgc     2400

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc     2460

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct     2520

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa     2580

acttgatttg ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc     2640

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact     2700

caaccctatc tcgggctatt cttttgattt ataagggatt ttgccgattt cggcctattg     2760

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt     2820

tacaatttta tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc     2880

ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc     2940

ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc     3000

accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat     3060

gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc     3120

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     3180

ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc     3240

ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt     3300

gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct     3360

caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac     3420

ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact     3480

cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa     3540

gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga     3600

taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt     3660

tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga     3720

agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg     3780

caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat     3840

ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat     3900

tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc     3960

agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga     4020

tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc     4080

agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag     4140

gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc     4200

gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt     4260

tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt     4320

gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat     4380

accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc     4440

accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa     4500

gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg     4560

ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag     4620

atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag     4680

gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa     4740

cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt     4800

gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg     4860

gttcctggcc ttttgctggc cttttgctca catgt                                4895


<210>  28
<211>  6045
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 28-Representative FHL AAV Vector (with hRPE65 
       Promoter)

<400>  28
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgta tatttattga agtttaatat tgtgtttgtg      180

atacagaagt atttgcttta attctaaata aaaattttat gcttttattg ctggtttaag      240

aagatttgga ttatccttgt actttgagga gaagtttctt atttgaaata ttttggaaac      300

aggtctttta atgtggaaag atagatatta atctcctctt ctattactct ccaagatcca      360

acaaaagtga ttataccccc caaaatatga tggtagtatc ttatactacc atcattttat      420

aggcataggg ctcttagctg caaataatgg aactaactct aataaagcag aacgcaaata      480

ttgtaaatat tagagagcta acaatctctg ggatggctaa aggatggagc ttggaggcta      540

cccagccagt aacaatattc cgggctccac tgttgaatgg agacactaca actgccttgg      600

atgggcagag atattatgga tgctaagccc caggtgctac cattaggact tctaccactg      660

tccctaacgg gtggagccca tcacatgcct atgccctcac tgtaaggaaa tgaagctact      720

gttgtatatc ttgggaagca cttggattaa ttgttataca gttttgttga agaagacccc      780

tagggtaagt agccataact gcacactaaa tttaaaattg ttaatgagtt tctcaaaaaa      840

aatgttaagg ttgttagctg gtatagtata tatcttgcct gttttccaag gacttctttg      900

ggcagtacct tgtctgtgct ggcaagcaac tgagacttaa tgaaagagta ttggagatat      960

gaatgaattg atgctgtata ctctcagagt gccaaacata taccaatgga caagaaggtg     1020

aggcagagag cagacaggca ttagtgacaa gcaaagatat gcagaatttc attctcagca     1080

aatcaaaagt cctcaacctg gttggaagaa tattggcact gaatggtatc aataaggttg     1140

ctagagaggg ttagaggtgc acaatgtgct tccataacat tttatacttc tccaatctta     1200

gcactaatca aacatggttg aatactttgt ttactataac tcttacagag ttataagatc     1260

tgtgaagaca gggacaggga caatacccat ctctgtctgg ttcataggtg gtatgtaata     1320

gatattttta aaaataagtg agttaatgaa tgagggtgag aatgaaggca cagaggtatt     1380

agggggaggt gggccccaga gaatggtgcc aaggtccagt ggggtgactg ggatcagctc     1440

aggcctgacg ctggccactc ccacctagct cctttctttc taatctgttc tcattctcct     1500

tgggaaggat tgaggtctct ggaaaacagc caaacaactg ttatgggaac agcaagccca     1560

aataaagcca agcatcaggg ggatctgaga gctgaaagca acttctgttc cccctccctc     1620

agctgaaggg gtggggaagg gctcccaaag ccataactcc ttttaaggga tttagaaggc     1680

ataaaaaggc ccctggctga gaacttcctt cttcattctg cagtaccggt ctcgaaggcc     1740

tgcaggcggc cgccgccacc atgaatgaga cttctagcaa agattatttg ccttatgtta     1800

tgggctattt gtgtagcaga agattgcaat gaacttcctc caagaagaaa tacagaaatt     1860

ctgacaggtt cctggtctga ccaaacatat ccagaaggca cccaggctat ctataaatgc     1920

cgccctggat atagatctct tggaaatgta ataatggtat gcaggaaggg agaatgggtt     1980

gctcttaatc cattaaggaa atgtcagaaa aggccctgtg gacatcctgg agatactcct     2040

tttggtactt ttacccttac aggaggaaat gtgtttgaat atggtgtaaa agctgtgtat     2100

acatgtaatg aggggtatca attgctaggt gagattaatt accgtgaatg tgacacagat     2160

ggatggacca atgatattcc tatatgtgaa gttgtgaagt gtttaccagt gacagcacca     2220

gagaatggaa aaattgtcag tagtgcaatg gaaccagatc gggaatacca ttttggacaa     2280

gcagtacggt ttgtatgtaa ctcaggctac aagattgaag gagatgaaga aatgcattgt     2340

tcagacgatg gtttttggag taaagagaaa ccaaagtgtg tggaaatttc atgcaaatcc     2400

ccagatgtta taaatggatc tcctatatct cagaagatta tttataagga gaatgaacga     2460

tttcaatata aatgtaacat gggttatgaa tacagtgaaa gaggagatgc tgtatgcact     2520

gaatctggat ggcgtccgtt gccttcatgt gaagaaaaat catgtgataa tccttatatt     2580

ccaaatggtg actactcacc tttaaggatt aaacacagaa ctggagatga aatcacgtac     2640

cagtgtagaa atggttttta tcctgcaacc cggggaaata cagcaaaatg cacaagtact     2700

ggctggatac ctgctccgag atgtaccttg aaaccttgtg attatccaga cattaaacat     2760

ggaggtctat atcatgagaa tatgcgtaga ccatactttc cagtagctgt aggaaaatat     2820

tactcctatt actgtgatga acattttgag actccgtcag gaagttactg ggatcacatt     2880

cattgcacac aagatggatg gtcgccagca gtaccatgcc tcagaaaatg ttattttcct     2940

tatttggaaa atggatataa tcaaaatcat ggaagaaagt ttgtacaggg taaatctata     3000

gacgttgcct gccatcctgg ctacgctctt ccaaaagcgc agaccacagt tacatgtatg     3060

gagaatggct ggtctcctac tcccagatgc atccgtgtca gctttaccct ctgataagat     3120

atcgatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     3180

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     3240

atatcgttaa ctcgagggat cccacgtgct gattttgtag gtaaccacgt gcggaccgag     3300

cggccgcagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     3360

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     3420

agcgagcgag cgcgcagctg cctgcagggg cgcctgatgc ggtattttct ccttacgcat     3480

ctgtgcggta tttcacaccg catacgtcaa agcaaccata gtacgcgccc tgtagcggcg     3540

cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc     3600

tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc     3660

gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg     3720

accccaaaaa acttgatttg ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg     3780

tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg     3840

gaacaacact caaccctatc tcgggctatt cttttgattt ataagggatt ttgccgattt     3900

cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa     3960

tattaacgtt tacaatttta tggtgcactc tcagtacaat ctgctctgat gccgcatagt     4020

taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc     4080

cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt     4140

caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg     4200

ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc     4260

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac     4320

aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt     4380

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag     4440

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     4500

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     4560

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     4620

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     4680

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     4740

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     4800

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     4860

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     4920

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     4980

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     5040

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag     5100

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     5160

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     5220

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt     5280

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     5340

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     5400

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     5460

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     5520

gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga     5580

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     5640

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     5700

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     5760

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa     5820

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     5880

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     5940

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     6000

cctttttacg gttcctggcc ttttgctggc cttttgctca catgt                     6045


<210>  29
<211>  4948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 29-Representative FHL AAV Vector (with HSP70 Promoter)

<400>  29
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgtt aactagtcct gcagggccgc ccactccccc      180

ttcctctcag ggtccctgtc ccctccagtg aatcccagaa gactctggag agttctgagc      240

agggggcggc actctggcct ctgattggtc caaggaaggc tggggggcag gacgggaggc      300

gaaaaccctg gaatattccc gacctggcag cctcatcgag ctcggtgatt ggctcagaag      360

ggaaaaggcg ggtctccgtg acgacttata aaagcccagg ggcaagcggt ccggataacg      420

gctagcctga ggagctgctg cgacagtcca ctaccttttt cgagagtgac tcccgttgtc      480

ccaaggcttc ccagagcgaa cctgtgcggc tgcaggcacc ggcgcgtcga gtttccggcg      540

tccggaagga ccgagctctt ctcgcggatc cagtgttccg tttccagccc ccaatctcag      600

agcggagccg acagagagca gggaaccacc ggtctcgaag gcctgcaggc ggccgccgcc      660

accatgaatg agacttctag caaagattat ttgccttatg ttatgggcta tttgtgtagc      720

agaagattgc aatgaacttc ctccaagaag aaatacagaa attctgacag gttcctggtc      780

tgaccaaaca tatccagaag gcacccaggc tatctataaa tgccgccctg gatatagatc      840

tcttggaaat gtaataatgg tatgcaggaa gggagaatgg gttgctctta atccattaag      900

gaaatgtcag aaaaggccct gtggacatcc tggagatact ccttttggta cttttaccct      960

tacaggagga aatgtgtttg aatatggtgt aaaagctgtg tatacatgta atgaggggta     1020

tcaattgcta ggtgagatta attaccgtga atgtgacaca gatggatgga ccaatgatat     1080

tcctatatgt gaagttgtga agtgtttacc agtgacagca ccagagaatg gaaaaattgt     1140

cagtagtgca atggaaccag atcgggaata ccattttgga caagcagtac ggtttgtatg     1200

taactcaggc tacaagattg aaggagatga agaaatgcat tgttcagacg atggtttttg     1260

gagtaaagag aaaccaaagt gtgtggaaat ttcatgcaaa tccccagatg ttataaatgg     1320

atctcctata tctcagaaga ttatttataa ggagaatgaa cgatttcaat ataaatgtaa     1380

catgggttat gaatacagtg aaagaggaga tgctgtatgc actgaatctg gatggcgtcc     1440

gttgccttca tgtgaagaaa aatcatgtga taatccttat attccaaatg gtgactactc     1500

acctttaagg attaaacaca gaactggaga tgaaatcacg taccagtgta gaaatggttt     1560

ttatcctgca acccggggaa atacagcaaa atgcacaagt actggctgga tacctgctcc     1620

gagatgtacc ttgaaacctt gtgattatcc agacattaaa catggaggtc tatatcatga     1680

gaatatgcgt agaccatact ttccagtagc tgtaggaaaa tattactcct attactgtga     1740

tgaacatttt gagactccgt caggaagtta ctgggatcac attcattgca cacaagatgg     1800

atggtcgcca gcagtaccat gcctcagaaa atgttatttt ccttatttgg aaaatggata     1860

taatcaaaat catggaagaa agtttgtaca gggtaaatct atagacgttg cctgccatcc     1920

tggctacgct cttccaaaag cgcagaccac agttacatgt atggagaatg gctggtctcc     1980

tactcccaga tgcatccgtg tcagctttac cctctgataa gatatcgata cattgatgag     2040

tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat     2100

gctattgctt tatttgtaac cattataagc tgcaataaac aagatatcgt taactcgagg     2160

gatcccacgt gctgattttg taggtaacca cgtgcggacc gagcggccgc aggaacccct     2220

agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc     2280

aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag     2340

ctgcctgcag gggcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     2400

ccgcatacgt caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt     2460

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc     2520

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg     2580

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat     2640

ttgggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg     2700

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct     2760

atctcgggct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa     2820

aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt     2880

ttatggtgca ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac     2940

ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga     3000

caagctgtga ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa     3060

cgcgcgagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata     3120

atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     3180

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     3240

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     3300

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     3360

aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc     3420

ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa     3480

gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc     3540

cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt     3600

acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact     3660

gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac     3720

aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata     3780

ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta     3840

ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg     3900

gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat     3960

aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt     4020

aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga     4080

aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa     4140

gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag     4200

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     4260

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     4320

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     4380

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     4440

actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct     4500

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     4560

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     4620

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     4680

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     4740

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     4800

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     4860

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     4920

gccttttgct ggccttttgc tcacatgt                                        4948


<210>  30
<211>  4959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 30-Representative FHL AAV Vector (with PCK1 Promoter)

<400>  30
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc tgcggccgag cccccagtta ggttaggcat ttccaatctt      180

tgccaataag ccacatattt gcccaagtta gggtgcatcc ttcccatgaa ctttgactgt      240

gacctttgac tatggggtga catcttatag ctgtggtgtt ttgccaacca gcagctcttg      300

gtacacaaaa tgtgctgcta gcaggtgccc cggccaacct tgtccttgac ccacctgcct      360

gttaagaaaa gggtgttgtg ttttgcaaca gcagtaaaat gggtcaaggt ttagtcagtt      420

ggaagttgtg tcaaaactca ctatggttgg ttgagggctc gaagtctccc agcattcatt      480

aacaactatc tgttcaatga ttatctccct ggggcgtgtt gcagtgagtt ggcccaaagc      540

ataactgacc ctggccgtga tccagagacc tgccccctga cgtcagtggc gagcctccct      600

gggtgcagct gaggggcagg gctattcttt tccacagtac cggtctcgaa ggcctgcagg      660

cggccgccgc caccatgaat gagacttcta gcaaagatta tttgccttat gttatgggct      720

atttgtgtag cagaagattg caatgaactt cctccaagaa gaaatacaga aattctgaca      780

ggttcctggt ctgaccaaac atatccagaa ggcacccagg ctatctataa atgccgccct      840

ggatatagat ctcttggaaa tgtaataatg gtatgcagga agggagaatg ggttgctctt      900

aatccattaa ggaaatgtca gaaaaggccc tgtggacatc ctggagatac tccttttggt      960

acttttaccc ttacaggagg aaatgtgttt gaatatggtg taaaagctgt gtatacatgt     1020

aatgaggggt atcaattgct aggtgagatt aattaccgtg aatgtgacac agatggatgg     1080

accaatgata ttcctatatg tgaagttgtg aagtgtttac cagtgacagc accagagaat     1140

ggaaaaattg tcagtagtgc aatggaacca gatcgggaat accattttgg acaagcagta     1200

cggtttgtat gtaactcagg ctacaagatt gaaggagatg aagaaatgca ttgttcagac     1260

gatggttttt ggagtaaaga gaaaccaaag tgtgtggaaa tttcatgcaa atccccagat     1320

gttataaatg gatctcctat atctcagaag attatttata aggagaatga acgatttcaa     1380

tataaatgta acatgggtta tgaatacagt gaaagaggag atgctgtatg cactgaatct     1440

ggatggcgtc cgttgccttc atgtgaagaa aaatcatgtg ataatcctta tattccaaat     1500

ggtgactact cacctttaag gattaaacac agaactggag atgaaatcac gtaccagtgt     1560

agaaatggtt tttatcctgc aacccgggga aatacagcaa aatgcacaag tactggctgg     1620

atacctgctc cgagatgtac cttgaaacct tgtgattatc cagacattaa acatggaggt     1680

ctatatcatg agaatatgcg tagaccatac tttccagtag ctgtaggaaa atattactcc     1740

tattactgtg atgaacattt tgagactccg tcaggaagtt actgggatca cattcattgc     1800

acacaagatg gatggtcgcc agcagtacca tgcctcagaa aatgttattt tccttatttg     1860

gaaaatggat ataatcaaaa tcatggaaga aagtttgtac agggtaaatc tatagacgtt     1920

gcctgccatc ctggctacgc tcttccaaaa gcgcagacca cagttacatg tatggagaat     1980

ggctggtctc ctactcccag atgcatccgt gtcagcttta ccctctgata agatatcgat     2040

acattgatga gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg     2100

aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa caagatatcg     2160

ttaactcgag ggatcccacg tgctgatttt gtaggtaacc acgtgcggac cgagcggccg     2220

caggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     2280

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     2340

cgagcgcgca gctgcctgca ggggcgcctg atgcggtatt ttctccttac gcatctgtgc     2400

ggtatttcac accgcatacg tcaaagcaac catagtacgc gccctgtagc ggcgcattaa     2460

gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc gccctagcgc     2520

ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag     2580

ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac ctcgacccca     2640

aaaaacttga tttgggtgat ggttcacgta gtgggccatc gccctgatag acggtttttc     2700

gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa actggaacaa     2760

cactcaaccc tatctcgggc tattcttttg atttataagg gattttgccg atttcggcct     2820

attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac aaaatattaa     2880

cgtttacaat tttatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc     2940

agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     3000

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     3060

catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg     3120

tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa     3180

cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac     3240

cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg     3300

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc     3360

tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg     3420

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga     3480

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc     3540

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag     3600

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga     3660

gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg     3720

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga     3780

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt     3840

tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact     3900

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt     3960

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg     4020

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta     4080

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac     4140

tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat ttttaattta     4200

aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt     4260

tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt     4320

tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt     4380

gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc     4440

agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg     4500

tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg     4560

ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt     4620

cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac     4680

tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg     4740

acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg     4800

gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat     4860

ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt     4920

tacggttcct ggccttttgc tggccttttg ctcacatgt                            4959


<210>  31
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 31-CAG Promoter

<400>  31
gttaacttgg caaagaattc tgcagtcgac ggtaccgcgg gcccgggatc caccggtcgc       60

caccatggtg cgctcctcca agaacgtcat caaggagttc atgcgcttca aggtgcgcat      120

ggagggcacc gtgaacggcc acgagttcga gatcgagggc gagggcgagg gccgccccta      180

cgagggccac aacaccgtga agctgaaggt gaccaagggc ggccccctgc ccttcgcctg      240

ggacatcctg tccccccagt tccagtacgg ctccaaggtg tacgtgaagc accccgccga      300

catccccgac tacaagaagc tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa      360

cttcgaggac ggcggcgtgg tgaccgtgac ccaggactcc tccctgcagg acggctgctt      420

catctacaag gtgaagttca tcggcgtgaa cttcccctcc gacggccccg taatgcagaa      480

gaagaccatg ggctgggagg cctccaccga gcgcctgtac ccccgcgacg gcgtgctgaa      540

gggcgagatc cacaaggccc tgaagctgaa ggacggcggc cactacctgg tggagttcaa      600

gtccatctac atggccaaga agcccgtgca gctgcccggc tactactacg tggactccaa      660

gctggacatc acctcccaca acgaggacta caccatcgtg gagcagtacg agcgcaccga      720

gggccgccac cacctgttcc tgtagcggcc gcactcctca ggtgcaggct gcctatcaga      780

aggtggtggc tggtgtggcc aatgccctgg ctcacaaata ccactgagat ctttttccct      840

ctgccaaaaa ttatggggac atcatgaagc cccttgagca tctgacttct ggctaataaa      900

ggaaatttat tttcattgca atagtgtgtt ggaatttttt gtgtctctca ctcggaagga      960

catatgggag ggcaaatc                                                    978


<210>  32
<211>  1585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 32- hRPE65 Promoter

<400>  32
gttaactata tttattgaag tttaatattg tgtttgtgat acagaagtat ttgctttaat       60

tctaaataaa aattttatgc ttttattgct ggtttaagaa gatttggatt atccttgtac      120

tttgaggaga agtttcttat ttgaaatatt ttggaaacag gtcttttaat gtggaaagat      180

agatattaat ctcctcttct attactctcc aagatccaac aaaagtgatt atacccccca      240

aaatatgatg gtagtatctt atactaccat cattttatag gcatagggct cttagctgca      300

aataatggaa ctaactctaa taaagcagaa cgcaaatatt gtaaatatta gagagctaac      360

aatctctggg atggctaaag gatggagctt ggaggctacc cagccagtaa caatattccg      420

ggctccactg ttgaatggag acactacaac tgccttggat gggcagagat attatggatg      480

ctaagcccca ggtgctacca ttaggacttc taccactgtc cctaacgggt ggagcccatc      540

acatgcctat gccctcactg taaggaaatg aagctactgt tgtatatctt gggaagcact      600

tggattaatt gttatacagt tttgttgaag aagaccccta gggtaagtag ccataactgc      660

acactaaatt taaaattgtt aatgagtttc tcaaaaaaaa tgttaaggtt gttagctggt      720

atagtatata tcttgcctgt tttccaagga cttctttggg cagtaccttg tctgtgctgg      780

caagcaactg agacttaatg aaagagtatt ggagatatga atgaattgat gctgtatact      840

ctcagagtgc caaacatata ccaatggaca agaaggtgag gcagagagca gacaggcatt      900

agtgacaagc aaagatatgc agaatttcat tctcagcaaa tcaaaagtcc tcaacctggt      960

tggaagaata ttggcactga atggtatcaa taaggttgct agagagggtt agaggtgcac     1020

aatgtgcttc cataacattt tatacttctc caatcttagc actaatcaaa catggttgaa     1080

tactttgttt actataactc ttacagagtt ataagatctg tgaagacagg gacagggaca     1140

atacccatct ctgtctggtt cataggtggt atgtaataga tatttttaaa aataagtgag     1200

ttaatgaatg agggtgagaa tgaaggcaca gaggtattag ggggaggtgg gccccagaga     1260

atggtgccaa ggtccagtgg ggtgactggg atcagctcag gcctgacgct ggccactccc     1320

acctagctcc tttctttcta atctgttctc attctccttg ggaaggattg aggtctctgg     1380

aaaacagcca aacaactgtt atgggaacag caagcccaaa taaagccaag catcaggggg     1440

atctgagagc tgaaagcaac ttctgttccc cctccctcag ctgaaggggt ggggaagggc     1500

tcccaaagcc ataactcctt ttaagggatt tagaaggcat aaaaaggccc ctggctgaga     1560

acttccttct tcattctgca gttgg                                           1585


<210>  33
<211>  1230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 33- CFH Amino Acid Sequence

<400>  33

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  
    1220                 1225                 1230 


<210>  34
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 34- FHL1 Amino Acid Sequence

<400>  34

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  35

<400>  35
000

<210>  36
<211>  223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 36- MECP Promoter Sequence

<400>  36
ggccgaaatg gacaggaaat ctcgccaatt gacggcatcg ccgctgagac tcccccctcc       60

cccgtcctcc ccgtcccagc ccggccatca cagccaatga cgggcgggct cgcagcggcg      120

ccgagggcgg ggcgcgggcg cgcaggtgca gcagcgcgcg ggccggccaa gagggcgggg      180

cgcgacgtcg gccgtgcggg gtcccggcgt cggcggcgcg cgc                        223


<210>  37
<211>  1213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 37- Exemplary CFH Amino Acid Sequence

<400>  37

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 


Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     


Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         


His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             


Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn His 
    370                 375                 380                 


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys 
            420                 425                 430         


Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr 
        435                 440                 445             


Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val 
    450                 455                 460                 


Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly 
465                 470                 475                 480 


Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro Val Phe 
                485                 490                 495     


Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu Asn Asp 
            500                 505                 510         


Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr Gly Ser 
        515                 520                 525             


Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp Leu Pro 
    530                 535                 540                 


Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val His Leu 
545                 550                 555                 560 


Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu Lys 
                565                 570                 575     


Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val Gln 
            580                 585                 590         


Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln 
        595                 600                 605             


Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys 
    610                 615                 620                 


Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr 
625                 630                 635                 640 


Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val 
                645                 650                 655     


Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr 
            660                 665                 670         


Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        675                 680                 685             


Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    690                 695                 700                 


Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
705                 710                 715                 720 


Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                725                 730                 735     


Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            740                 745                 750         


Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        755                 760                 765             


Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    770                 775                 780                 


Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
785                 790                 795                 800 


Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                805                 810                 815     


Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            820                 825                 830         


Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        835                 840                 845             


Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    850                 855                 860                 


Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
865                 870                 875                 880 


Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                885                 890                 895     


Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            900                 905                 910         


Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        915                 920                 925             


Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    930                 935                 940                 


Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
945                 950                 955                 960 


Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                965                 970                 975     


Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            980                 985                 990         


Gly Glu Gln Val Thr Tyr Thr Cys  Ala Thr Tyr Tyr Lys  Met Asp Gly 
        995                 1000                 1005             


Ala Ser  Asn Val Thr Cys Ile  Asn Ser Arg Trp Thr  Gly Arg Pro 
    1010                 1015                 1020             


Thr Cys  Arg Asp Thr Ser Cys  Val Asn Pro Pro Thr  Val Gln Asn 
    1025                 1030                 1035             


Ala Tyr  Ile Val Ser Arg Gln  Met Ser Lys Tyr Pro  Ser Gly Glu 
    1040                 1045                 1050             


Arg Val  Arg Tyr Gln Cys Arg  Ser Pro Tyr Glu Met  Phe Gly Asp 
    1055                 1060                 1065             


Glu Glu  Val Met Cys Leu Asn  Gly Asn Trp Thr Glu  Pro Pro Gln 
    1070                 1075                 1080             


Cys Lys  Asp Ser Thr Gly Lys  Cys Gly Pro Pro Pro  Pro Ile Asp 
    1085                 1090                 1095             


Asn Gly  Asp Ile Thr Ser Phe  Pro Leu Ser Val Tyr  Ala Pro Ala 
    1100                 1105                 1110             


Ser Ser  Val Glu Tyr Gln Cys  Gln Asn Leu Tyr Gln  Leu Glu Gly 
    1115                 1120                 1125             


Asn Lys  Arg Ile Thr Cys Arg  Asn Gly Gln Trp Ser  Glu Pro Pro 
    1130                 1135                 1140             


Lys Cys  Leu His Pro Cys Val  Ile Ser Arg Glu Ile  Met Glu Asn 
    1145                 1150                 1155             


Tyr Asn  Ile Ala Leu Arg Trp  Thr Ala Lys Gln Lys  Leu Tyr Ser 
    1160                 1165                 1170             


Arg Thr  Gly Glu Ser Val Glu  Phe Val Cys Lys Arg  Gly Tyr Arg 
    1175                 1180                 1185             


Leu Ser  Ser Arg Ser His Thr  Leu Arg Thr Thr Cys  Trp Asp Gly 
    1190                 1195                 1200             


Lys Leu  Glu Tyr Pro Thr Cys  Ala Lys Arg 
    1205                 1210             


<210>  38
<211>  1231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 38- Exemplary Precursor CFH Amino Acid Sequence

<400>  38

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  39
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 39- CFH (1-4) Amino Acid Sequence

<400>  39

Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly 
1               5                   10                  15      


Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys 
            20                  25                  30          


Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg 
        35                  40                  45              


Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg 
    50                  55                  60                  


Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr 
65                  70                  75                  80  


Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn 
                85                  90                  95      


Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr 
            100                 105                 110         


Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu 
        115                 120                 125             


Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu 
    130                 135                 140                 


Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn 
145                 150                 155                 160 


Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp 
                165                 170                 175     


Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys 
            180                 185                 190         


Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr 
        195                 200                 205             


Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr 
    210                 215                 220                 


Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu 
225                 230                 235                 240 


Pro Ser Cys Glu Glu Lys 
                245     


<210>  40
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 40- CFH (1-5) Amino Acid Sequence

<400>  40

Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly 
1               5                   10                  15      


Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys 
            20                  25                  30          


Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg 
        35                  40                  45              


Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg 
    50                  55                  60                  


Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr 
65                  70                  75                  80  


Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn 
                85                  90                  95      


Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr 
            100                 105                 110         


Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu 
        115                 120                 125             


Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu 
    130                 135                 140                 


Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn 
145                 150                 155                 160 


Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp 
                165                 170                 175     


Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys 
            180                 185                 190         


Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr 
        195                 200                 205             


Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr 
    210                 215                 220                 


Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu 
225                 230                 235                 240 


Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly 
                245                 250                 255     


Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr 
            260                 265                 270         


Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala 
        275                 280                 285             


Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu Lys 
    290                 295                 300                 


<210>  41
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 41- CFH (1-7) Amino Acid Sequence

<400>  41

Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr Gly 
1               5                   10                  15      


Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr Lys 
            20                  25                  30          


Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys Arg 
        35                  40                  45              


Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys Arg 
    50                  55                  60                  


Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu Thr 
65                  70                  75                  80  


Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys Asn 
                85                  90                  95      


Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp Thr 
            100                 105                 110         


Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys Leu 
        115                 120                 125             


Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met Glu 
    130                 135                 140                 


Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys Asn 
145                 150                 155                 160 


Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp Asp 
                165                 170                 175     


Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys Lys 
            180                 185                 190         


Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile Tyr 
        195                 200                 205             


Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu Tyr 
    210                 215                 220                 


Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu 
225                 230                 235                 240 


Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn Gly 
                245                 250                 255     


Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile Thr 
            260                 265                 270         


Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr Ala 
        275                 280                 285             


Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu Lys 
    290                 295                 300                 


Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu Asn 
305                 310                 315                 320 


Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser Tyr 
                325                 330                 335     


Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp His 
            340                 345                 350         


Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu Arg 
        355                 360                 365             


Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr Gly 
    370                 375                 380                 


Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro Gly 
385                 390                 395                 400 


Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn Gly 
                405                 410                 415     


Trp Ser Pro Thr Pro Arg Cys Ile Arg Val 
            420                 425     


<210>  42
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 42- CFH (19-20) Amino Acid Sequence

<400>  42

Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr 
1               5                   10                  15      


Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln 
            20                  25                  30          


Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg 
        35                  40                  45              


Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile 
    50                  55                  60                  


Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala 
65                  70                  75                  80  


Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys 
                85                  90                  95      


Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr 
            100                 105                 110         


Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
        115                 120                 125     


<210>  43
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 43- CFH (18-20) Amino Acid Sequence

<400>  43

Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val Ser Arg 
1               5                   10                  15      


Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg 
            20                  25                  30          


Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly 
        35                  40                  45              


Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly 
    50                  55                  60                  


Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser 
65                  70                  75                  80  


Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr 
                85                  90                  95      


Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser 
            100                 105                 110         


Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met 
        115                 120                 125             


Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr 
    130                 135                 140                 


Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg 
145                 150                 155                 160 


Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys 
                165                 170                 175     


Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
            180                 185 


