                         SEQUENCE LISTING

<110>  INTEGRATED DNA TECHNOLOGIES INC.
       WOODLEY, Jessica
       THOMMANDRU, Bernice
       DOBOSY, Joseph
       BEHLKE, Mark
       CLORE, Adam
       RETTIG, Garrett
       SUN, Beimeng
 
<120>  MODIFIED DOUBLE-STRANDED DONOR TEMPLATES

<130>  013670-9060-WO01

<140>  PCT/US2020/057105
<141>  2020-10-23

<150>  US 62/925,366
<151>  2019-10-24

<160>  235   

<170>  PatentIn version 3.5

<210>  1
<211>  1219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gattgcctca gatcacacta tctccacttg cccagccctg tggaagatta gcggccatgt       60

attccaatgt gataggaact gtaacctctg gaaaaaggta cgaattcgag ggcagaggca      120

gtctgctgac atgcggtgac gtggaagaga atcccggccc ttctagaatg gttagcaagg      180

gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg      240

gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc      300

tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc      360

tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct      420

tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg      480

gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg      540

agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag cttgagtaca      600

actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga      660

acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc      720

agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc      780

agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg      840

tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaactg tgccttctag      900

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac      960

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     1020

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     1080

caggcatgct ggggatgcgg tgggctctat ggcggtacca gaggggtgag ctttcccctt     1140

gcctgcccct actgggtttt gtgacctcca aaggactcac aggaatgacc tccaacacct     1200

ttgagaagac caggccctc                                                  1219


<210>  2
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
gattgcctca gatcacacta tctcc                                             25


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
gagggcctgg tcttctcaaa g                                                 21


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  4
gattgcctca gatcacacta tctcc                                             25


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  5
gagggcctgg tcttctcaaa g                                                 21


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  6
gattgcctca gatcacacta tctcc                                             25


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  7
gagggcctgg tcttctcaaa g                                                 21


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<400>  8
gattgcctca gatcacacta tctcc                                             25


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<400>  9
gagggcctgg tcttctcaaa g                                                 21


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Phosphorothioate 5'-3' linkage

<400>  10
gattgcctca gatcacacta tctcc                                             25


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Phosphorothioate 5'-3' linkage

<400>  11
gagggcctgg tcttctcaaa g                                                 21


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-TEG (triethylene glycol)

<400>  12
gattgcctca gatcacacta tctcc                                             25


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-TEG (triethylene glycol)

<400>  13
gagggcctgg tcttctcaaa g                                                 21


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-locked (2'-oxygen-4'-carbon methylene linkage)

<400>  14
gattgcctca gatcacacta tctcc                                             25


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-locked (2'-oxygen-4'-carbon methylene linkage)

<400>  15
gagggcctgg tcttctcaaa g                                                 21


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-Sp18 (hexaethylene glycol)

<400>  16
gattgcctca gatcacacta tctcc                                             25


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-Sp18 (hexaethylene glycol)

<400>  17
gagggcctgg tcttctcaaa g                                                 21


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-SpC3 (1,3-propanediol)

<400>  18
gattgcctca gatcacacta tctcc                                             25


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gagggcctgg tcttctcaaa g                                                 21


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  20
gattgcctca gatcacacta tctcc                                             25


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  21
gagggcctgg tcttctcaaa g                                                 21


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
acctctggaa aaaggtaaga                                                   20


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
agaaccagtt ttcaggcgg                                                    19


<210>  24
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
accgcatgtc agcagac                                                      17


<210>  25
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-FAM (5,6 fluorescein dye)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  ZEN fluorescent quencher is located between G9 and G10

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  3'-FQ (Iowa Black FQ fluorescent quencher)

<400>  25
tggaaaaagg tacgaattcg agggca                                            26


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
cgctaatctt ccacaggg                                                     18


<210>  27
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-FAM (5,6 fluorescein dye)

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  ZEN fluorescent quencher is located between A9 and A10

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  3'-FQ (Iowa Black FQ fluorescent quencher)

<400>  27
tctggaaaaa ggtagattgc ctcagatca                                         29


<210>  28
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
attccaatgt gataggaact gtaacctctg gaaaaaggta gaattcttag ctctgtttac       60

gtcccagcgg gcatgagagt aaagaggggt gagctttccc cttgcctgcc cctactgggt      120

tt                                                                     122


<210>  29
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
attccaatgt gataggaact gtaacc                                            26


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
aaacccagta ggggcaggc                                                    19


<210>  31
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  31
attccaatgt gataggaact gtaacc                                            26


<210>  32
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  32
aaacccagta ggggcaggc                                                    19


<210>  33
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  33
attccaatgt gataggaact gtaacc                                            26


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  34
aaacccagta ggggcaggc                                                    19


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Phosphorothioate 5'-3' linkage

<400>  35
attccaatgt gataggaact gtaacctctg                                        30


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Phosphorothioate 5'-3' linkage

<400>  36
aaacccagta ggggcaggc                                                    19


<210>  37
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  37
attccaatgt gataggaact gtaacc                                            26


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  38
aaacccagta ggggcaggc                                                    19


<210>  39
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-Sp18 (hexaethylene glycol)

<400>  39
attccaatgt gataggaact gtaacc                                            26


<210>  40
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-Sp18 (hexaethylene glycol)

<400>  40
aaacccagta ggggcaggc                                                    19


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  41
attccaatgt gataggaact gtaacctctg                                        30


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  42
aaacccagta ggggcaggc                                                    19


<210>  43
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  43
attccaatgt gataggaact gtaacctctg                                        30


<210>  44
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  44
aaacccagta ggggcaggc                                                    19


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
cttgtccctc tttgccttct ct                                                22


<210>  46
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
gggtggatct gagtggaaga aa                                                22


<210>  47
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
gcggccatgt attccaatgt gataggaact gtaacctctg gaaaaaggta gaattcttag       60

ctctgtttac gtcccagcgg gcatgagagt aaagaggggt gagctttccc cttgcctgcc      120

cctactgggt tttgtgacct cc                                               142


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gcggccatgt attccaatgt g                                                 21


<210>  49
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
ggaggtcaca aaacccagta gg                                                22


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  50
gcggccatgt attccaatgt g                                                 21


<210>  51
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  51
ggaggtcaca aaacccagta gg                                                22


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Phosphorothioate 5'-3' linkage

<400>  52
gcggccatgt attccaatgt g                                                 21


<210>  53
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Phosphorothioate 5'-3' linkage

<400>  53
ggaggtcaca aaacccagta gg                                                22


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
cctctaaggt ttgcttacga                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
aattatgggg attactagga                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
gccaaggact caaacccaga                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
ccccgttctc ctgtggattc                                                   20


<210>  58
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
aagaatgttg tgataaaagg tgatgct                                           27


<210>  59
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
acacatccat gggacttctg cctc                                              24


<210>  60
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
gataggaact gtaacctctg gaaaaaggta gaattcagag gggtgagctt tccccttgcc       60

tgcccc                                                                  66


<210>  61
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
ggggcaggca aggggaaagc tcacccctct gaattctacc tttttccaga ggttacagtt       60

cctatc                                                                  66


<210>  62
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate modification

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Hairpin Region

<400>  62
tcgttttcga gataggaact gtaacctctg gaaaaaggta gaattcagag gggtgagctt       60

tccccttgcc tgcccc                                                       76


<210>  63
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate modification

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Hairpin Region

<400>  63
tcgttttcga ggggcaggca aggggaaagc tcacccctct gaattctacc tttttccaga       60

ggttacagtt cctatc                                                       76


<210>  64
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate modification

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Hairpin Region

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified ribocytidine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methoxyethyl modified ribocytidine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  64
tcgttttcga gataggaact gtaacctctg gaaaaaggta gaattcagag gggtgagctt       60

tccccttgcc tgcccc                                                       76


<210>  65
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-phosphate modification

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Hairpin Region

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified ribocytidine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methoxyethyl modified ribocytidine

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  65
tcgttttcga ggggcaggca aggggaaagc tcacccctct gaattctacc tttttccaga       60

ggttacagtt cctatc                                                       76


<210>  66
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Non-template 2'-O-methoxyethyl modified riboadenosine

<400>  66
agataggaac tgtaacctct ggaaaaaggt agaattcaga ggggtgagct ttccccttgc       60

ctgcccc                                                                 67


<210>  67
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Non-template 2'-O-methoxyethyl modified riboadenosine

<400>  67
aggggcaggc aaggggaaag ctcacccctc tgaattctac ctttttccag aggttacagt       60

tcctatc                                                                 67


<210>  68
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  68
attccaatgt gataggaact gtaacc                                            26


<210>  69
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  69
aaacccagta ggggcaggc                                                    19


<210>  70
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-riboadenosine

<400>  70
attccaatgt gataggaact gtaacc                                            26


<210>  71
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-riboadenosine

<400>  71
aaacccagta ggggcaggc                                                    19


<210>  72
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-locked (2'-oxygen-4'-carbon methylene linkage)

<400>  72
attccaatgt gataggaact gtaacc                                            26


<210>  73
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-locked (2'-oxygen-4'-carbon methylene linkage)

<400>  73
aaacccagta ggggcaggc                                                    19


<210>  74
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methyl modified riboadenosine

<400>  74
attccaatgt gataggaact gtaacc                                            26


<210>  75
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  2'-O-methyl modified riboadenosine

<400>  75
aaacccagta ggggcaggc                                                    19


<210>  76
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-fluoro modified riboadenosine

<400>  76
attccaatgt gataggaact gtaacc                                            26


<210>  77
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-fluoro modified riboadenosine

<400>  77
aaacccagta ggggcaggc                                                    19


<210>  78
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Non-template 2'-O-methoxyethyl modified riboguanosine

<400>  78
gattccaatg tgataggaac tgtaacc                                           27


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Non-template 2'-O-methoxyethyl modified riboguanosine

<400>  79
gaaacccagt aggggcaggc                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
tgccctggta acggccaaag                                                   20


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
tcggacagaa aggcattcac a                                                 21


<210>  82
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
caacggcaaa gggagaactt aaac                                              24


<210>  83
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
agtgccttgt ctgtagtgtc aactcattgc tgccccttcc gaattcttag ctctgtttac       60

gtcccagcgg gcatgagagt aatagtaatc cccataattt agctctccat ttcatagtct      120

tt                                                                     122


<210>  84
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
aaggaggagg cctaaggatg gggcttttct gtcaccaatc gaattcttag ctctgtttac       60

gtcccagcgg gcatgagagt aactgtccct agtggcccca ctgtggggtg gaggggacag      120

at                                                                     122


<210>  85
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
tgccaagctc tccctcccag gatcctctct ggctccatcg gaattcttag ctctgtttac       60

gtcccagcgg gcatgagagt aataagcaaa ccttagaggt tctggcaagg agagagatgg      120

ct                                                                     122


<210>  86
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
aggccaatgg ggaggacatc gatgtcacct ccaatgacta gaattcttag ctctgtttac       60

gtcccagcgg gcatgagagt aagggtgggc aaccacaaac ccacgagggc agagtgctgc      120

tt                                                                     122


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
agtgccttgt ctgtagtgtc a                                                 21


<210>  88
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
aaagactatg aaatggagag ctaaattatg                                        30


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  89
agtgccttgt ctgtagtgtc a                                                 21


<210>  90
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  90
aaagactatg aaatggagag ctaaattatg                                        30


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  91
agtgccttgt ctgtagtgtc a                                                 21


<210>  92
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  92
aaagactatg aaatggagag ctaaattatg                                        30


<210>  93
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  93
agtgccttgt ctgtagtgtc a                                                 21


<210>  94
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  94
aaagactatg aaatggagag ctaaattatg                                        30


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  95
agtgccttgt ctgtagtgtc a                                                 21


<210>  96
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  96
aaagactatg aaatggagag ctaaattatg                                        30


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  97
agtgccttgt ctgtagtgtc a                                                 21


<210>  98
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  98
aaagactatg aaatggagag ctaaattatg                                        30


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99
aaggaggagg cctaaggatg g                                                 21


<210>  100
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100
atctgtcccc tccacccc                                                     18


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  101
aaggaggagg cctaaggatg g                                                 21


<210>  102
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  102
atctgtcccc tccacccc                                                     18


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  103
aaggaggagg cctaaggatg g                                                 21


<210>  104
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  104
atctgtcccc tccacccc                                                     18


<210>  105
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  105
aaggaggagg cctaaggatg g                                                 21


<210>  106
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  106
atctgtcccc tccacccc                                                     18


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  107
aaggaggagg cctaaggatg g                                                 21


<210>  108
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  108
atctgtcccc tccacccc                                                     18


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  109
aaggaggagg cctaaggatg g                                                 21


<210>  110
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  110
atctgtcccc tccacccc                                                     18


<210>  111
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  111
tgccaagctc tccctccc                                                     18


<210>  112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  112
agccatctct ctccttgcca g                                                 21


<210>  113
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  113
tgccaagctc tccctccc                                                     18


<210>  114
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  114
agccatctct ctccttgcca g                                                 21


<210>  115
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  115
tgccaagctc tccctccc                                                     18


<210>  116
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  116
agccatctct ctccttgcca g                                                 21


<210>  117
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  117
tgccaagctc tccctccc                                                     18


<210>  118
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  118
agccatctct ctccttgcca g                                                 21


<210>  119
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  119
tgccaagctc tccctccc                                                     18


<210>  120
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  120
agccatctct ctccttgcca g                                                 21


<210>  121
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  121
tgccaagctc tccctccc                                                     18


<210>  122
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  122
agccatctct ctccttgcca g                                                 21


<210>  123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  123
aggccaatgg ggaggacatc                                                   20


<210>  124
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124
aagcagcact ctgccctcg                                                    19


<210>  125
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  125
aggccaatgg ggaggacatc                                                   20


<210>  126
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  126
aagcagcact ctgccctcg                                                    19


<210>  127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  127
aggccaatgg ggaggacatc                                                   20


<210>  128
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<400>  128
aagcagcact ctgccctcg                                                    19


<210>  129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  129
aggccaatgg ggaggacatc                                                   20


<210>  130
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  130
aagcagcact ctgccctcg                                                    19


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  131
aggccaatgg ggaggacatc                                                   20


<210>  132
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<400>  132
aagcagcact ctgccctcg                                                    19


<210>  133
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  133
aggccaatgg ggaggacatc                                                   20


<210>  134
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  134
aagcagcact ctgccctcg                                                    19


<210>  135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135
aattatgggg attactagga                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136
ggggccacta gggacaggat                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137
cctctaaggt ttgcttacga                                                   20


<210>  138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138
gtcacctcca atgactaggg                                                   20


<210>  139
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  139
acactctttc cctacacgac gctcttccga tctcagaact gtccttcagg ttc              53


<210>  140
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140
gtgactggag ttcagacgtg tgctcttccg atctcactgt ttcatttcat ccgtg            55


<210>  141
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141
acactctttc cctacacgac gctcttccga tctgagagat ggctccagga aatg             54


<210>  142
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142
gtgactggag ttcagacgtg tgctcttccg atctcacttc aggacagcat gtttg            55


<210>  143
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  143
acactctttc cctacacgac gctcttccga tctgatcagt gaaacgcacc aga              53


<210>  144
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  144
gtgactggag ttcagacgtg tgctcttccg atctcctcct tcctagtctc ctgatatt         58


<210>  145
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  145
acactctttc cctacacgac gctcttccga tctagaagaa gaagggctcc ca               52


<210>  146
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  146
gtgactggag ttcagacgtg tgctcttccg atctcaggga gtggccagag t                51


<210>  147
<211>  502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  147
gattgcctca gatcacacta tctccacttg cccagccctg tggaagatta gcggccatgt       60

attccaatgt gataggaact gtaacctctg gaaaaaggta cgaattcgag ggcagaggca      120

gtctgctgac atgcggtgac gtggaagaga atcccggccc ttctagataa ctgtgccttc      180

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc      240

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg      300

tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa      360

tagcaggcat gctggggatg cggtgggctc tatggcggta ccagaggggt gagctttccc      420

cttgcctgcc cctactgggt tttgtgacct ccaaaggact cacaggaatg acctccaaca      480

cctttgagaa gaccaggccc tc                                               502


<210>  148
<211>  700
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  148
gattgcctca gatcacacta tctccacttg cccagccctg tggaagatta gcggccatgt       60

attccaatgt gataggaact gtaacctctg gaaaaaggta cgaattcgag ggcagaggca      120

gtctgctgac atgcggtgac gtggaagaga atcccggccc ttctagaatg gttagcaagg      180

gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg      240

gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc      300

tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc      360

tgacctaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc      420

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc      480

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg      540

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcggtacc      600

agaggggtga gctttcccct tgcctgcccc tactgggttt tgtgacctcc aaaggactca      660

caggaatgac ctccaacacc tttgagaaga ccaggccctc                            700


<210>  149
<211>  1219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  149
gattgcctca gatcacacta tctccacttg cccagccctg tggaagatta gcggccatgt       60

attccaatgt gataggaact gtaacctctg gaaaaaggta cgaattcgag ggcagaggca      120

gtctgctgac atgcggtgac gtggaagaga atcccggccc ttctagaatg gttagcaagg      180

gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg      240

gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc      300

tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccaccc      360

tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct      420

tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg      480

gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg      540

agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag cttgagtaca      600

actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga      660

acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc      720

agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc      780

agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg      840

tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaactg tgccttctag      900

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac      960

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     1020

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     1080

caggcatgct ggggatgcgg tgggctctat ggcggtacca gaggggtgag ctttcccctt     1140

gcctgcccct actgggtttt gtgacctcca aaggactcac aggaatgacc tccaacacct     1200

ttgagaagac caggccctc                                                  1219


<210>  150
<211>  502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  150
ctccctccct ggcccaggtg aaggtgtggt tccagaaccg gaggacaaag tacaaacggc       60

agaagctgga ggaggaaggg cctgagtccg agcagaagaa cgaattcgag ggcagaggca      120

gtctgctgac atgcggtgac gtggaagaga atcccggccc ttctagataa ctgtgccttc      180

tagttgccag ccatctgttg tttgcgcctc actcgtgcct tcattgaccc tggaaggtgc      240

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg      300

tcattctatt ctggcgtatc gagtggctca ggacagcaag agcgaggatt gggaagacaa      360

tagcaggcat gctggggatg cggtgggctc tatggcggta ccgaagggct cccatcacat      420

caaccggtgg cgcattgcca cgaagcaggc caatggggag gacatcgatg tcacctccaa      480

tgactagggt gggcaaccac aa                                               502


<210>  151
<211>  700
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  151
ctccctccct ggcccaggtg aaggtgtggt tccagaaccg gaggacaaag tacaaacggc       60

agaagctgga ggaggaaggg cctgagtccg agcagaagaa cgaattcgag ggcagaggca      120

gtctgctgac atgcggtgac gtggaagaga atcccggccc ttctagaatg gttagcaagg      180

gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg      240

gccacaagtt cagcgtgtcc ggcgagggag agggcgatgc cacctacggc aagctgaccc      300

tgaagttcat ctgcaccacc ggcaagctgc cagtgccctg gcctaccctc gtgaccaccc      360

tgacctaact gtgccttcta gttgccagcc atctgttgtt tgcgcctcac tcgtgccttc      420

attgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc      480

gcattgtctg agtaggtgtc attctattct ggcgtatcga gtggctcagg acagcaagag      540

cgaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcggtacc      600

gaagggctcc catcacatca accggtggcg cattgccacg aagcaggcca atggggagga      660

catcgatgtc acctccaatg actagggtgg gcaaccacaa                            700


<210>  152
<211>  1219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  152
ctccctccct ggcccaggtg aaggtgtggt tccagaaccg gaggacaaag tacaaacggc       60

agaagctgga ggaggaaggg cctgagtccg agcagaagaa cgaattcgag ggcagaggca      120

gtctgctgac atgcggtgac gtggaagaga atcccggccc ttctagaatg gttagcaagg      180

gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg      240

gccacaagtt cagcgtgtcc ggcgagggag agggcgatgc cacctacggc aagctgaccc      300

tgaagttcat ctgcaccacc ggcaagctgc cagtgccctg gcctaccctc gtgaccaccc      360

tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct      420

tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg      480

gcaactacaa gacccgtgcc gaggtgaagt tcgaaggcga caccctggtg aaccgcatcg      540

agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag cttgagtaca      600

actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga      660

acttcaagat ccgccacaac atcgaggacg gtagcgtgca gctcgctgac cactaccagc      720

agaacactcc tatcggagac ggtcctgtgc tgctgccaga caaccactac ctgagcacac      780

agtccgctct gagcaaagac cctaacgaga agcgcgatca catggtcctg ctggagttcg      840

tgacagccgc tgggatcact ctcggcatgg acgagctgta caagtaactg tgccttctag      900

ttgccagcca tctgttgttt gcgcctcact cgtgccttca ttgaccctgg aaggtgccac      960

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     1020

ttctattctg gcgtatcgag tggctcagga cagcaagagc gaggattggg aagacaatag     1080

caggcatgct ggggatgcgg tgggctctat ggcggtaccg aagggctccc atcacatcaa     1140

ccggtggcgc attgccacga agcaggccaa tggggaggac atcgatgtca cctccaatga     1200

ctagggtggg caaccacaa                                                  1219


<210>  153
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  153
gattgcctca gatcacacta tctccacttg cc                                     32


<210>  154
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  154
gagggcctgg tcttctcaaa ggtgttg                                           27


<210>  155
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  155
gattgcctca gatcacacta tctccacttg cc                                     32


<210>  156
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  156
gagggcctgg tcttctcaaa ggtgttg                                           27


<210>  157
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  157
ctccctccct ggcccaggtg aag                                               23


<210>  158
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  158
ttgtggttgc ccaccctagt cattgga                                           27


<210>  159
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  159
ctccctccct ggcccaggtg aag                                               23


<210>  160
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  160
ttgtggttgc ccaccctagt cattgga                                           27


<210>  161
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  161
gagtccgagc agaagaagaa                                                   20


<210>  162
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  162
tttctgttgg tgctgatatt gcctttatgt gattgctgta tgtctcc                     47


<210>  163
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  163
acttgcctgt cgctctatct tcgaatctgc caggtgctga ta                          42


<210>  164
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  164
tttctgttgg tgctgatatt gcctgtgctt tacccagttc tct                         43


<210>  165
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  165
acttgcctgt cgctctatct tcgctgggtc tctgacatct tt                          42


<210>  166
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (3)..(2)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  166
gattgcctca gatcacacta tctccacttg cc                                     32


<210>  167
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  167
gagggcctgg tcttctcaaa ggtgttg                                           27


<210>  168
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  168
gattgcctca gatcacacta tctccacttg cc                                     32


<210>  169
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  169
gagggcctgg tcttctcaaa ggtgttg                                           27


<210>  170
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified ribocytidine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  170
ctccctccct ggcccaggtg aag                                               23


<210>  171
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  171
ttgtggttgc ccaccctagt cattgga                                           27


<210>  172
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  172
ctccctccct ggcccaggtg aag                                               23


<210>  173
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  173
ttgtggttgc ccaccctagt cattgg                                            26


<210>  174
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  174
gtcgtaccga ctggtagatg acagcaaacc                                        30


<210>  175
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  175
ggtctcgact atacgcccgt tttcggatc                                         29


<210>  176
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  176
gtcgtaccga ctggtagatg acagcaaacc                                        30


<210>  177
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  177
ggtctcgact atacgcccgt tttcggatc                                         29


<210>  178
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  178
gtcgtaccga ctggtagatg acagcaaacc                                        30


<210>  179
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  179
ggtctcgact atacgcccgt tttcggatc                                         29


<210>  180
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  180
gtcgtaccga ctggtagatg acagcaaacc                                        30


<210>  181
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  181
ggtctcgact atacgcccgt tttcggatc                                         29


<210>  182
<211>  1180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  182
aacgaccact ttgtcaagct catttcctgg tatgtggctg gggccagaga ctggctctta       60

aaaagtgcag ggtctggcgc cctctggtgg ctggctcaga aaaagggccc tgacaactct      120

tttcatcttc taggtatgac aacgaatttg gctacagcaa cagggtggtg gacctcatgg      180

cccacatggc ctccaaggag ggatctggcg ccaccaattt cagcctgctg aaacaggctg      240

gcgacgtgga agagaaccct ggacctgtga gcaagggcga ggagctgttc accggggtgg      300

tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg      360

agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca      420

agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca      480

gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct      540

acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg      600

tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg      660

aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac aacgtctata      720

tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg      780

aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc      840

ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca      900

acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg      960

gcatggacga gctgtacaag taagacccct ggaccaccag ccccagcaag agcacaagag     1020

gaagagagag accctcactg ctggggagtc cctgccacac tcagtccccc accacactga     1080

atctcccctc ctcacagttg ccatgtagac cccttgaaga ggggaggggc ctagggagcc     1140

gcaccttgtc atgtaccatc aataaagtac cctgtgctca                           1180


<210>  183
<211>  1188
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  183
gtcgtaccga ctggtagatg acagcaaacc tgttcccttt tcggctctgc aacaccgcct       60

agaccgaccg gatacacggg tagggcttcc gctttacccg tctccctcct ggcgcttgtc      120

ctcctctccc agtcggcacc acagcggtgg ctgccgggcg tggtgtcggt gggtcggttg      180

gtttttgtct caccgttggt gtccgtgccg ttcagttgcc cgccatggct ggatctggtg      240

gtactagtgg aagcaagggt gaggagctgt tcaccggagt ggtgcctatc ctggtcgagc      300

tggacggcga cgtaaacggt cacaagttca gcgtgcgtgg tgagggcgag ggcgatgcca      360

ccaacggcaa gctgaccctg aagttcatct gcaccactgg caagctgcct gttccatggc      420

caaccctcgt gactacactg acctacggcg ttcagtgctt cagccgttac cctgaccata      480

tgaagcgtca cgacttcttc aagtctgcca tgcctgaagg ctacgtccag gagcgtacca      540

tcagcttcaa ggacgatggc acctacaaga ctcgtgccga ggtgaagttc gagggtgaca      600

ccctggtgaa ccgcatcgag ctgaagggta tcgacttcaa ggaggacggc aacatcctgg      660

gtcacaagct ggagtacaac ttcaacagcc acaacgtcta tatcaccgcc gacaagcaga      720

agaacggcat caaggccaac ttcaagattc gtcacaacgt ggaggacggt agcgtgcagc      780

tcgcagacca ctaccagcag aacacgccta tcggcgacgg tccagtgttg ctgccagaca      840

accactacct gagcacccag tccgtgctga gcaaagaccc gaacgagaag cgcgatcaca      900

tggtcctgct ggagttcgtg accgcagccg gtatcactgg aaccggtgct ggaagtggtg      960

agctggatcc gttcggcgcc cctgccggcg cccctggcgg tcccgcgctg gggaacggag     1020

tggccggcgc cggcgaagaa gacccggctg cggccttctt ggcgcagcaa gagagcgaga     1080

ttgcgggcat cgagaacgac gaggccttcg ccatcctgga cggcggcgcc cccgggcccc     1140

agccgcacgg cgagccgccg atccgaaaac gggcgtatag tcgagacc                  1188


<210>  184
<211>  1129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  184
tcaggggcgg ggcgccgccc ccggaagtac ttccccttaa aggctggggc ctgccggaaa       60

tggcgcagcg gcagggaggg gctcttcacc cagtccggca gttgaagctc ggcgctcggg      120

ttacccctgc agcgacgccc cctggtccca cagataccac tgctgctccc gccctttcgc      180

tcctcggccg cgcaatgggc ggatcgggtg ggactagtgg cagcaagggc gaggagctgt      240

tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc cacaagttca      300

gcgtgcgcgg cgagggcgag ggcgatgcca ccaacggcaa gctgaccctg aagttcatct      360

gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg acctacggcg      420

tgcagtgctt cagccgctac cccgaccaca tgaagcgcca cgacttcttc aagtccgcca      480

tgcccgaagg ctacgtccag gagcgcacca tcagcttcaa ggacgacggc acctacaaga      540

cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca      600

tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac ttcaacagcc      660

acaacgtcta tatcaccgcc gacaagcaga agaacggcat caaggccaac ttcaagatcc      720

gccacaacgt ggaggacggc agcgtgcagc tcgccgacca ctaccagcag aacaccccca      780

tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag tccgtgctga      840

gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg accgccgccg      900

ggatcactgg aaccggtgct ggaagtggta cacgcgacga cgagtacgac tacctcttta      960

aaggtgaggc catgggctct cgcactctac acagtcctcg ttcggggacc cgggccactc     1020

ccggtggacc ctcgtgccgg ccacccctgc actgatatag gcctccctca gcccttcctt     1080

tttgtgcggt tccgtctcct acccagctca gcctcttctc ccccgctca                 1129


<210>  185
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  185
cctccaagga gtaagacccc                                                   20


<210>  186
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  186
gaacggatcc agctcagcca                                                   20


<210>  187
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  187
ggtagtcgta ctcgtcgtcg                                                   20


<210>  188
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  188
acgaagtgtt ggatataagc cagactgtaa gtga                                   34


<210>  189
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  189
tctaagcaat tataagccat ttcacataaa actcttttag gttaaa                      46


<210>  190
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  190
acgaagtgtt ggatataagc cagactgtaa gtga                                   34


<210>  191
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  191
tctaagcaat tataagccat ttcacataaa actcttttag gttaaa                      46


<210>  192
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  192
gccctgtagt ctctctgtat gttatatgtc acattttgta a                           41


<210>  193
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  193
aagtaattca cttacagtct ggcttatatc caacacttcg                             40


<210>  194
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  194
gccctgtagt ctctctgtat gttatatgtc acattttgta a                           41


<210>  195
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  195
aagtaattca cttacagtct ggcttatatc caacacttcg                             40


<210>  196
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  196
agcttgctgg tgaaaaggac ccca                                              24


<210>  197
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  197
aatgtgcctc tctacaaata ttctctaagc aattataagc catttc                      46


<210>  198
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  198
agcttgctgg tgaaaaggac ccca                                              24


<210>  199
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  199
aatgtgcctc tctacaaata ttctctaagc aattataagc catttc                      46


<210>  200
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  200
acgtcagtct tctcttttgt aatgccctgt agtc                                   34


<210>  201
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  201
gatggttaaa tgattgacaa aaaaagtaat tcacttacag tctgg                       45


<210>  202
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  202
acgtcagtct tctcttttgt aatgccctgt agtc                                   34


<210>  203
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboguanosine

<400>  203
gatggttaaa tgattgacaa aaaaagtaat tcacttacag tctgg                       45


<210>  204
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  204
tgtagtctct ctgtatgtta tatgtcacat tttgtaatta acagct                      46


<210>  205
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  205
atttagataa agaaaacatc acttttaaat ctaatactgg caaatg                      46


<210>  206
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  206
tgtagtctct ctgtatgtta tatgtcacat tttgtaatta acagct                      46


<210>  207
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  207
atttagataa agaaaacatc acttttaaat ctaatactgg caaatg                      46


<210>  208
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  208
catggtacac tcagcacgga tgaaatgaaa cag                                    33


<210>  209
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  209
agcaattata agccatttca cataaaactc ttttaggtta aagatg                      46


<210>  210
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  210
catggtacac tcagcacgga tgaaatgaaa cag                                    33


<210>  211
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  211
agcaattata agccatttca cataaaactc ttttaggtta aagatg                      46


<210>  212
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  212
tctcagattc cagtttcagc aaatttgctt gatatgtaca gc                          42


<210>  213
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  213
tgaatagagt ggttgcacaa acttacggat catttg                                 36


<210>  214
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  214
atggtgagca agggcgagga gct                                               23


<210>  215
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  215
agagtgatcc cggcggcggt ca                                                22


<210>  216
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  216
cccacaattc gctctcacca aacctgag                                          28


<210>  217
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  217
agtagtaata gtagtagtat taaataattt gataaataat tttagcaata tagttttttg       60

t                                                                       61


<210>  218
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  218
cccacaattc gctctcacca aacctgag                                          28


<210>  219
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  219
agtagtaata gtagtagtat taaataattt gataaataat tttagcaata tagttttttg       60

t                                                                       61


<210>  220
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified ribocytidine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified ribocytidine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  220
cccacaattc gctctcacca aacctgag                                          28


<210>  221
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  221
agtagtaata gtagtagtat taaataattt gataaataat tttagcaata tagttttttg       60

t                                                                       61


<210>  222
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin moiety

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  222
cccacaattc gctctcacca aacctgag                                          28


<210>  223
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin moiety

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  223
agtagtaata gtagtagtat taaataattt gataaataat tttagcaata tagttttttg       60

t                                                                       61


<210>  224
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin moiety

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  224
ggtacaagtg gatttgacta attacgagtg gcttgataa                              39


<210>  225
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin moiety

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  225
aaacaatgca ctcacttctt cctagagaag agtacattc                              39


<210>  226
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  226
cctattaaat aaaagaataa gcagtattat taagtagccc tgcatttca                   49


<210>  227
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  227
catctgcttt tttcccgtgt cattctctgg actg                                   34


<210>  228
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  228
cccacaattc gctctcacca aacctgag                                          28


<210>  229
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  229
agtagtaata gtagtagtat taaataattt gataaataat tttagcaata tagttttttg       60

t                                                                       61


<210>  230
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  230
cccacaattc gctctcacca aacctgag                                          28


<210>  231
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<400>  231
agtagtaata gtagtagtat taaataattt gataaataat tttagcaata tagttttttg       60

t                                                                       61


<210>  232
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified ribocytidine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified ribocytidine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified ribocytidine

<400>  232
cccacaattc gctctcacca aacctgag                                          28


<210>  233
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-O-methoxyethyl modified riboadenosine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methoxyethyl modified riboguanosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-O-methoxyethyl modified 5-methyluridine (ribothymidine)

<400>  233
agtagtaata gtagtagtat taaataattt gataaataat tttagcaata tagttttttg       60

t                                                                       61


<210>  234
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin moiety

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  234
ccacaattcg ctctcaccaa acctgag                                           27


<210>  235
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  5'-biotin moiety

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Phosphorothioate 5'-3' linkage

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Phosphorothioate 5'-3' linkage

<400>  235
agtagtaata gtagtagtat taaataattt gataaataat tttagcaata tagttttttg       60

t                                                                       61


