                         SEQUENCE LISTING

<110>  Shire Human Genetic Therapies, Inc.
 
<120>  ADENO-ASSOCIATED VIRUS VECTORS BASED GENE THERAPY FOR HEREDITARY 
       ANGIOEDEMA

<130>  SHR-2012WO

<140>  PCT/US20/56984
<141>  2020-10-23

<150>  US 62/924,877
<151>  2019-10-23

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210>  2
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1 wild type sequence

<400>  2
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga tcttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc cagatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

tga                                                                   1503


<210>  3
<211>  1503
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga tcttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc cagatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

tag                                                                   1503


<210>  4
<211>  1503
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized SERPING1 HA03

<400>  4
atggccagca ggctgaccct gctgaccctg ctgctgctgc tgctggctgg agacagggcc       60

agcagcaacc ccaatgccac cagcagcagc agccaggacc ctgagagcct gcaggacagg      120

ggagagggca aggtggctac cacagtgatc agcaagatgc tgtttgtgga gcccatcctg      180

gaggtgagca gcctgcccac caccaacagc accaccaaca gtgccaccaa gatcacagcc      240

aacaccacag atgagcccac cacccagccc accacagagc ccaccaccca gcccaccatc      300

cagcccaccc agcccaccac ccagctgccc acagacagcc ccacccagcc caccacaggc      360

agcttctgcc ctggccctgt gaccctgtgc agtgacctgg agagccacag cacagaggct      420

gtgctgggag atgccctggt ggacttcagc ctgaagctgt accatgcctt cagtgccatg      480

aagaaggtgg agaccaacat ggccttcagc cccttcagca ttgccagcct gctgacccag      540

gtgctgctgg gagctggaga gaacaccaag accaacctgg agagcatcct gagctacccc      600

aaggacttca cctgtgtgca ccaggccctg aagggcttca ccaccaaggg agtgaccagt      660

gtgagccaga tcttccacag ccctgacctg gccatcaggg acacctttgt gaatgccagc      720

aggaccctgt acagcagcag ccccagggtg ctgagcaaca acagtgatgc caacctggag      780

ctgatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctggacagc      840

ctgcccagtg acaccaggct ggtgctgctg aatgccatct acctgagtgc caagtggaag      900

accacctttg accccaagaa gaccaggatg gagcccttcc acttcaagaa cagtgtgatc      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc acttcattga ccagaccctg     1020

aaggccaagg tgggccagct tcagcttagc cacaacctga gcctggtgat cctggtgccc     1080

cagaacctga agcacaggct ggaggacatg gagcaggccc tgagccccag tgtgttcaag     1140

gccatcatgg agaagctgga gatgagcaag ttccagccca ccctgctgac cctgcccagg     1200

atcaaggtga ccaccagcca ggacatgctg agcatcatgg agaagctgga gttctttgac     1260

ttcagctatg acctgaacct gtgtggcctg acagaggacc ctgacctgca agtcagtgcc     1320

atgcagcacc agacagtgct ggagctgaca gagacaggag tggaggctgc tgctgccagt     1380

gccatcagtg tggccaggac cctgctggtg tttgaggtgc agcagccctt cctgtttgtg     1440

ctgtgggacc agcagcacaa gttccctgtg ttcatgggca gggtgtatga ccccagggcc     1500

tag                                                                   1503


<210>  5
<211>  1503
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized SERPING1 HA04

<400>  5
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggagaaggca aggtggcaac aacagttatc tccaagatgc tatttgttga acccatcctg      180

gaggtttcca gcttgcctac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggc      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggct      420

gtgttgggag atgctttggt agatttctcc ctgaagctct accatgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca ttgccagcct ccttacccag      540

gtcctgctgg gggctggaga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca tcaggccctg aagggcttca ctaccaaagg tgtcacctca      660

gtctctcaga tcttccatag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgatgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctagacagt      840

ctgccctctg ataccaggct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaggccaaag tgggccagct ccagctgtcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatagact tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actacccagg     1200

atcaaagtga ctaccagcca ggatatgctc tcaatcatgg agaaattgga attctttgat     1260

ttttcttatg accttaacct gtgtggcctg acagaggacc cagatcttca ggtttctgct     1320

atgcagcatc agacagtgct ggaactgaca gagactggag tggaggctgc tgcagcctca     1380

gccatctctg tggccaggac cctgctggtc tttgaagtgc agcagccctt cctctttgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatgggca gagtatatga ccccagggcc     1500

tag                                                                   1503


<210>  6
<211>  1503
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon-optimized SERPING1 HA05

<400>  6
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggacagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggacc cagagagcct ccaagacaga      120

ggagaaggca aggtggcaac aacagtcatc tccaagatgc tctttgtgga acccatcctg      180

gaggtctcca gcctccctac aaccaactca acaaccaatt cagccaccaa gataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagactctc ctacccagcc cactactggc      360

tccttctgcc caggacctgt cactctctgc tctgacctgg agagccactc aacagaggct      420

gtgctgggag atgctctggt ggacttctcc ctgaagctct accatgcctt ctcagcaatg      480

aagaaagtgg agaccaacat ggccttttcc ccattcagca ttgccagcct cctgacccag      540

gtcctgctgg gggctggaga gaacaccaag acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca tcaggccctg aagggcttca ctaccaaggg tgtcacctca      660

gtctctcaga tcttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctgt acagcagcag ccccagagtc ctcagcaaca acagtgatgc caacctggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctggacagc      840

ctgccctctg acaccaggct ggtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaagaa ctcagtcata      960

aaggtgccca tgatgaatag caagaaatac cctgtggccc acttcattga ccaaactctc     1020

aaggccaagg tgggccagct ccagctgtcc cacaatctga gcctggtgat cctggtgccc     1080

cagaacctga agcacagact ggaagacatg gaacaggctc tcagcccttc tgtcttcaag     1140

gccatcatgg agaagctgga gatgtccaag ttccagccca ctctcctcac actccccagg     1200

atcaaggtca ctaccagcca ggacatgctc tcaatcatgg agaagctgga attctttgac     1260

ttttcttatg acctgaacct gtgtggcctg acagaggacc cagatctcca ggtctctgct     1320

atgcagcacc agacagtgct ggaactgaca gagactggag tggaggctgc tgcagcctca     1380

gccatctctg tggccaggac cctgctggtc tttgaagtgc agcagccctt cctctttgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatgggca gagtgtatga ccccagggcc     1500

tag                                                                   1503


<210>  7
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA06

<400>  7
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggacagggcc       60

tcctcaaacc ccaatgccac cagctccagc tcccaggacc cagagagcct ccaggacagg      120

ggggaaggca aggtggctac cacagtcatc tccaagatgc tctttgtgga gcccatcctg      180

gaggtctcca gcctccccac caccaactca accaccaact cagccaccaa gatcacagcc      240

aacaccactg atgagcccac cacacagccc accacagagc ccaccaccca gcccaccatc      300

cagcccaccc agcccaccac ccagctcccc acagactccc ccacccagcc caccactggc      360

tccttctgcc caggccctgt caccctctgc tctgacctgg agagccactc aacagaggct      420

gtgctggggg atgccctggt ggacttctcc ctgaagctct accatgcctt ctcagccatg      480

aagaaggtgg agaccaacat ggccttctcc cccttcagca ttgccagcct cctgacccag      540

gtcctgctgg gggctgggga gaacaccaag accaacctgg agagcatcct ctcctacccc      600

aaggacttca cctgtgtcca tcaggccctg aagggcttca ccaccaaggg agtcacctca      660

gtctcccaga tcttccacag cccagacctg gccatcaggg acacctttgt gaatgcctcc      720

aggaccctgt acagcagcag ccccagggtc ctcagcaaca acagtgatgc caacctggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagcaggct gctggacagc      840

ctgccctctg acaccaggct ggtcctcctc aatgccatct acctgagtgc caagtggaag      900

accacctttg atcccaagaa gaccaggatg gaacccttcc acttcaagaa ctcagtcatc      960

aaggtgccca tgatgaacag caagaagtac cctgtggccc acttcattga ccagaccctc     1020

aaggccaagg tgggccagct ccagctgtcc cacaacctga gcctggtgat cctggtgccc     1080

cagaacctga agcacaggct ggaggacatg gaacaggccc tcagcccctc tgtcttcaag     1140

gccatcatgg agaagctgga gatgtccaag ttccagccca ccctcctcac cctccccagg     1200

atcaaggtga ccaccagcca ggacatgctc tcaatcatgg agaagctgga gttctttgac     1260

ttctcctatg acctgaacct gtgtggcctg acagaggacc cagatctcca ggtctctgcc     1320

atgcagcacc agacagtgct ggaactgaca gagactggag tggaggctgc tgcagcctca     1380

gccatctctg tggccaggac cctgctggtc tttgaagtgc agcagccctt cctctttgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatgggca gggtgtatga ccccagggcc     1500

tag                                                                   1503


<210>  8
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA11

<400>  8
atggcatcaa ggctgaccct tctcaccctg ctcctgctgc ttctggctgg ggacagagcc       60

tccagcaacc ccaatgccac ctccagcagc tctcaagatc cagagtccct gcaagaccgg      120

ggagaaggca aggtggctac cacagtcatc tccaagatgc tctttgtgga acccatcctg      180

gaagtgtcct ccctccccac cactaactcc accacaaact ctgccactaa gatcacagcc      240

aacactacag atgagccaac tacccagcct acaacagagc ctaccaccca accaaccatc      300

cagccaaccc agcccaccac tcagctgccc acagacagcc caacacagcc cacaactggc      360

tccttctgcc ctggccctgt gaccctctgc agtgacttgg aaagccacag caccgaggct      420

gtgctgggag atgctctggt ggacttttct ctcaagctgt accatgcttt ctcagcaatg      480

aagaaagtag agaccaacat ggccttcagc cccttttcca ttgccagcct cctcactcaa      540

gtgctcctgg gggctggaga gaataccaaa accaacctgg agagcatcct ctcctacccc      600

aaggacttca cctgtgtgca ccaagccctg aaaggcttca caaccaaggg ggtgacttct      660

gtctcccaga tcttccactc tccagacctg gccatcagag acaccttcgt gaatgcaagt      720

aggaccctct acagctcctc cccaagggtg ctgtccaaca attctgatgc caatctggag      780

ctcatcaaca cctgggtggc caagaacaca aacaacaaga tttctaggct cctggactcc      840

ctgccttctg acacaagact ggttctgctg aatgctatct acctgtctgc aaagtggaag      900

accacctttg accccaaaaa gacaaggatg gagcccttcc attttaagaa ttcagtgatc      960

aaggtgccca tgatgaacag caagaagtac cctgttgccc acttcattga ccaaacactg     1020

aaggccaaag tgggccagct ccagctttcc cacaacctca gcctggtgat tctggtcccc     1080

cagaacttga agcaccggct ggaggacatg gagcaagcac tgagccccag tgtcttcaag     1140

gcaatcatgg aaaaactgga gatgtccaaa ttccagccca ctctgttgac cttgcccaga     1200

atcaaagtca ccaccagcca agatatgctg agtatcatgg agaagcttga gttctttgat     1260

ttctcctatg atctgaacct gtgtggcctg acagaagacc ctgacctcca agtcagtgcc     1320

atgcagcacc agacagtgtt ggagctgact gagactggtg tggaggcagc agccgcctca     1380

gccatctctg tggccagaac cctgctggtg tttgaggtgc agcagccttt cctgtttgtc     1440

ctgtgggacc agcaacacaa gttcccagtg ttcatgggca gagtgtatga cccaagggcc     1500

tga                                                                   1503


<210>  9
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA12

<400>  9
atggcaagca gactgacctt gctgacactg ctccttctcc tgctggctgg agaccgggcc       60

agcagcaacc ccaatgccac ttcttcctcc agtcaagacc cagagtccct gcaagacaga      120

ggagaaggca aggttgctac cactgtgatc tccaagatgc tgttcgtgga gcccatcctg      180

gaagtgtcca gcctgcccac cactaactcc accacaaaca gtgccaccaa aatcacagcc      240

aacactacag atgagccaac cacccaacca accacagaac ccacaacaca gcctaccatc      300

cagcctactc agcccaccac ccagcttcct acagactccc ccacccagcc aacaactggc      360

tccttctgcc ctggccctgt gactctgtgc tctgacctgg agagccacag caccgaggct      420

gtgctgggag atgctctggt ggacttctcc ctgaaactgt accacgcctt ttcagccatg      480

aagaaagtag agaccaacat ggccttcagc ccctttagca ttgcctccct cctcactcaa      540

gttctgctgg gggctgggga gaacacaaag accaacctgg aaagcatcct ctcctacccc      600

aaggacttca cctgtgtgca ccaagcactc aagggcttca caaccaaggg ggtgaccagt      660

gtctcccaga tcttccattc cccagacctg gccatcagag acacatttgt gaatgcatcc      720

agaaccctct acagctcctc tccaagggtg ctgtccaaca actcagatgc caatcttgag      780

ctgatcaaca cctgggtggc caaaaatacc aataacaaga tctcaaggct gctggacagc      840

ctccccagtg acaccagact tgtgctcctg aatgctatct acctgtctgc aaagtggaag      900

actacctttg atcccaaaaa gacaaggatg gagcctttcc acttcaagaa ctctgtcatc      960

aaagtgccca tgatgaacag caagaagtac cctgttgccc actttattga tcagaccctg     1020

aaggccaagg tgggccagct ccagctgtcc cacaaccttt ctctggtgat tctggtcccc     1080

cagaacctga agcacagatt ggaagacatg gagcaagccc tgagcccttc agtgtttaag     1140

gcaatcatgg agaagctgga gatgtccaaa ttccagccca ctctcctcac cctgcctagg     1200

atcaaggtca ccaccagcca agatatgctc tctatcatgg aaaagttgga gttctttgac     1260

ttttcctatg atctgaacct ctgtggcctg actgaggacc ctgacctcca agtgtcagca     1320

atgcagcacc agacagtgct ggagctcaca gagactgggg tggaagccgc agcagcctct     1380

gccatctctg tggctaggac ccttctggtc tttgaggtgc agcagccctt cctgtttgtc     1440

ctgtgggacc agcaacacaa gttcccagtg ttcatgggca gagtgtatga ccccagagcc     1500

tga                                                                   1503


<210>  10
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA13

<400>  10
atggcatcta ggctgacctt gctcactctg ctgcttctcc tcctggctgg agaccgggcc       60

tccagcaacc ccaatgctac ctcctccagt tcccaagatc cagagtccct gcaagacaga      120

ggagaaggca aggtggcaac cactgtcatc agcaagatgc tgtttgtgga acccatcctg      180

gaagtgtcca gcctccccac aaccaactcc accacaaatt cagccaccaa gatcactgcc      240

aacacaactg atgagcccac cacccaacca accacagagc caactaccca gcccaccatc      300

cagcccactc agcctaccac ccagcttcct actgacagcc caacacagcc aaccactggc      360

tccttctgcc ctggccctgt gaccctgtgc tctgacttgg aaagccacag cactgaagct      420

gtgctgggag atgctctggt ggacttttcc ctcaagctgt accacgcctt ctctgcaatg      480

aagaaggttg agaccaacat ggccttttct cccttcagca ttgccagcct gctgactcaa      540

gtgctgctgg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcctacccc      600

aaagatttca cctgtgtgca ccaagccctg aaaggcttca caacaaaggg ggtcacctct      660

gtctcccaga tcttccattc ccctgacctg gccatcagag acaccttcgt gaatgccagc      720

agaaccctct acagcagctc cccaagggtg ctctccaaca attctgatgc caatctggag      780

ctcatcaaca cctgggtggc caaaaacact aacaacaaga tttccagact cctggactcc      840

ctgcccagtg acacaaggtt ggtcctcctg aatgcaatct acctgtctgc taagtggaag      900

accacctttg atcccaagaa aaccagaatg gaaccattcc actttaagaa ctcagtgatc      960

aaggtcccca tgatgaacag caaaaagtac cctgttgccc acttcattga tcagaccctg     1020

aaggccaagg tgggccagct ccagctgtcc cacaacctct ctctggtcat tctggtgccc     1080

cagaacttga agcaccggct ggaagatatg gagcaagcac tgagcccctc tgtgttcaag     1140

gcaattatgg agaagcttga gatgtccaag ttccagccta cactgctcac cctgcctagg     1200

atcaaagtga ctaccagcca agacatgctc tcaatcatgg agaaactgga gttctttgac     1260

ttctcctatg atctgaacct gtgtggcctg actgaggacc cagacctcca agtcagtgcc     1320

atgcagcacc agacagtgtt ggagctgaca gaaactgggg tggaggcagc agccgcctct     1380

gccatcagtg tggctaggac cctgttggtg tttgaggtgc agcagccctt tctctttgtc     1440

ctgtgggacc agcaacacaa gtttcctgtc ttcatgggca gagtgtatga ccccagagcc     1500

tga                                                                   1503


<210>  11
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA14

<400>  11
atggccagca gactcaccct cctcactctg ctcctgcttc tgctggctgg ggaccgggcc       60

tctagcaacc ccaatgccac cagctcctcc agccaagatc cagaatctct gcaagacaga      120

ggagaaggca aggttgccac tactgtgatc agcaagatgc tctttgtgga gcccatcctg      180

gaagtgagca gcctccccac taccaacagc accactaact cagctaccaa gatcacagcc      240

aataccacag atgaacccac cacacagcct acaacagaac ctaccactca acccaccatc      300

cagcctactc agcccaccac ccagctgccc acagactccc caacccagcc aacaactggc      360

tccttctgcc ctggccctgt cacactctgc agtgacttgg agagccacag cactgaggct      420

gtgctgggag atgccctggt ggacttttcc ctcaagctct accacgcctt ctcagcaatg      480

aagaaagtag agaccaacat ggcattctct cctttcagca ttgcctccct gctgacccaa      540

gtcctcctgg gggctggaga gaacactaaa accaatcttg agtccatcct ctcctacccc      600

aaggacttca cctgtgtcca ccaagcactg aaaggcttca caaccaaagg agtgacctct      660

gtgtcccaga tcttccattc ccctgatctg gccatcagag acaccttcgt gaatgcttcc      720

agaaccttgt acagctctag cccaagggtg ctgtccaaca attctgatgc taatctggag      780

ctgatcaaca cctgggtggc caaaaacaca aacaacaaga tttctaggct cctggacagc      840

ctgccttctg acacaaggct ggttctgctg aatgcaatct acctgtctgc aaagtggaag      900

accacctttg accccaaaaa gacaaggatg gagccattcc acttcaagaa cagtgtcatc      960

aaagtgccca tgatgaactc caagaagtac ccagtggccc atttcattga tcagaccctg     1020

aaggccaagg tgggccagct ccagctttcc cacaacctct cactggtgat tctggtcccc     1080

cagaacctga agcaccggct ggaagatatg gagcaagccc tcagccccag tgtgtttaag     1140

gctatcatgg agaagctgga gatgtccaaa ttccagccca ctctcctgac actgccaagg     1200

atcaaggtca ccacctccca agacatgctg tcaatcatgg aaaaactgga gttctttgat     1260

ttctcctatg acctgaacct gtgtggcctg actgaggacc ctgacctcca agtgtctgcc     1320

atgcagcacc agacagtgct ggagctcaca gagactgggg tggaagccgc tgctgcctca     1380

gccatctcag tggctaggac cctgctggtc tttgaggtgc agcagccctt cctgtttgtc     1440

ctgtgggacc agcaacacaa gttccctgtg ttcatgggca gagtgtatga tcccagagcc     1500

tga                                                                   1503


<210>  12
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA15

<400>  12
atggcatcta ggctgacact gctcaccttg ctcctgctgc ttctggctgg ggacagagct       60

tcctccaacc ccaacgccac ctccagctct tcccaagacc ctgagtctct gcaagatagg      120

ggggagggca aggtggctac cacagtcatc agcaagatgc tctttgtgga acccatcctg      180

gaagtgagca gcctccccac taccaatagc accaccaaca gtgccacaaa gatcacagcc      240

aacactacag atgagccaac cactcagccc acaacagagc ctactaccca gcccaccatc      300

cagcccacac agcctaccac ccagcttcct acagacagcc ccactcaacc caccactggc      360

tccttctgcc ctggccctgt gaccctctgc agtgacttgg agagccacag cactgaggct      420

gtgctgggag atgctctggt ggacttttcc ctcaagctct accacgcctt ctctgcaatg      480

aagaaggttg agaccaacat ggcctttagc ccattcagca ttgcctcctt gctgacccaa      540

gtcctgctgg gggctggaga gaacaccaaa acaaatcttg agtccatcct ctcctacccc      600

aaagacttca cctgtgtgca ccaagcactg aaaggcttca caaccaaggg ggtgacttct      660

gtgtcccaga tcttccactc tcctgacctg gccatcagag acacctttgt caatgccagc      720

agaacccttt acagctcctc cccaagagtc ctcagcaaca attctgatgc caatctggag      780

ctgatcaaca cctgggtggc aaaaaacaca aacaacaaga tttccagact cctggactcc      840

ctgccttctg acacaaggct ggttctgctg aatgctatct acctgtctgc caagtggaag      900

accacatttg accccaagaa aaccagaatg gagcccttcc atttcaagaa ctcagtgatc      960

aaggtcccca tgatgaacag caaaaagtac cctgttgccc acttcattga tcagaccctg     1020

aaggccaaag tgggccagct ccagctgtcc cacaacctga gcctggtcat tctggtgccc     1080

cagaacctga agcacagact ggaagatatg gagcaagccc tgagcccttc agtctttaag     1140

gcaatcatgg agaagctgga gatgtccaag ttccagccaa ctctcctcac tctgcccaga     1200

atcaaagtca ccaccagcca agacatgctg agtatcatgg aaaaactgga gttctttgat     1260

ttctcctatg acctgaacct ctgtggcctg actgaggacc cagacctcca agtgtctgcc     1320

atgcagcacc agacagtgct ggagctcaca gaaactggtg tggaggccgc tgctgcctca     1380

gccatcagtg tggcccgcac cctgttggtg tttgaggtgc agcagccttt cctgttcgtg     1440

ctgtgggacc agcaacacaa gtttccagtg ttcatgggca gagtgtatga tccaagggcc     1500

tga                                                                   1503


<210>  13
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA16

<400>  13
atggcctcta ggctcaccct gctgacactg ctgctcctcc tgctggctgg agaccgggcc       60

agcagcaacc ccaatgctac cagctcctcc agtcaagacc ctgagtccct gcaagacaga      120

ggagaaggca aggttgccac tacagtcatc tccaagatgc tgtttgtaga gcccatcctg      180

gaagtgtcca gcctgcctac caccaatagc accaccaaca gtgccaccaa gatcacagcc      240

aataccacag atgagccaac cacccagcct acaacagagc ctaccactca acccaccatc      300

cagccaacac agcctactac ccagctgccc acagacagcc caactcagcc caccactggc      360

tccttctgcc ctggccctgt cacactctgc agtgacctgg aaagccacag cactgaggct      420

gtgctgggag atgctctggt ggacttttct ctgaaactgt accacgcctt ctctgcaatg      480

aagaaagtgg agaccaacat ggcattctcc ccattcagca ttgcctcctt gctgacccaa      540

gtgctcctgg gggctgggga gaacacaaaa acaaacctgg agagcatcct ctcctacccc      600

aaggacttca cctgtgtgca ccaagccctc aagggcttca caaccaaagg agtgacctct      660

gtgagccaga tcttccattc ccctgacctg gccattaggg acaccttcgt gaatgcaagc      720

cggaccctct acagcagctc tccaagagtc ctgtccaaca attctgatgc caacctagag      780

ctgatcaaca cctgggtggc aaagaacact aacaacaaga tttccagact cctggactcc      840

ctcccatctg acacaaggct ggtcctcctg aatgccatct acctgtctgc taagtggaag      900

accacatttg accccaaaaa gacaaggatg gaacccttcc acttcaaaaa ctcagtgatc      960

aaagtcccca tgatgaacag caagaagtac cctgtggccc atttcattga tcagaccctg     1020

aaggccaagg tgggccagct ccagctttcc cacaacctca gccttgtgat tctggtgccc     1080

cagaacttga agcacagact ggaggacatg gagcaagccc tgagccccag tgtcttcaag     1140

gcaatcatgg agaaacttga gatgtccaaa ttccagccca ctctgctcac tctccccaga     1200

atcaaggtca ccacctccca agatatgctc tcaattatgg agaagctgga gttctttgat     1260

ttttcctatg atctgaacct gtgtggcctg actgaagatc cagacctcca agtctctgcc     1320

atgcagcacc agacagtgtt ggagctcaca gaaactgggg tggaagccgc tgctgcctca     1380

gccatcagtg tggctaggac cctgttggtg tttgaggtgc agcagccctt tctctttgtg     1440

ctgtgggacc agcaacacaa gttcccagtg ttcatgggca gagtgtatga cccaagggcc     1500

tga                                                                   1503


<210>  14
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA17

<400>  14
atggcatccc gcctgaccct cctcaccctg cttctgctcc tgctggctgg agatagggcc       60

tccagcaacc ccaatgcaac cagcagctcc agccaagacc ctgagtccct gcaagacaga      120

ggagaaggca aggttgccac cactgtgatt tccaagatgc tgtttgtgga acccatcctg      180

gaagtgagca gcctcccaac aaccaacagc accaccaata gtgccacaaa aattacagcc      240

aataccacag atgagcctac cactcagcct acaacagaac ccaccaccca gcctaccatc      300

cagccgaccc agccaaccac acagctcccc actgactccc ccacacagcc caccactggc      360

tccttctgcc ctggacctgt gactctgtgc tctgacctgg aatctcactc cactgaggct      420

gtgctggggg atgctctggt ggatttttcc ctcaagctct accatgcctt ctctgccatg      480

aagaaggtgg agaccaacat ggccttttct cccttttcca ttgccagcct cctgacccaa      540

gtgctcctgg gagctgggga gaacaccaag accaaccttg agagcattct gtcctacccc      600

aaggacttta cctgtgtgca ccaagccctg aaaggcttca ccaccaaagg ggtgacctct      660

gtctcccaga tcttccacag ccctgatctg gccattaggg acacctttgt caatgcttcc      720

agaactctct attcttcctc cccacgggtc ctctccaaca attcagatgc caacctggag      780

ctgatcaaca cctgggtggc caaaaacaca aacaacaaga tctcaaggct cctggacagc      840

ctccccagtg acacacggct ggtgctcctg aatgccatct acctgtctgc caagtggaag      900

accacttttg acccaaaaaa gacaaggatg gagcccttcc atttcaagaa cagtgtgatc      960

aaggtcccca tgatgaatag caagaaatac cctgttgccc acttcattga tcagaccctg     1020

aaggccaaag tgggccagct gcagttgtcc cacaacctca gcctggtcat actggtgccc     1080

cagaacctga agcataggct ggaagacatg gaacaagcac tgagcccctc agtgttcaaa     1140

gctatcatgg agaagctgga gatgtccaaa ttccagccca ccctgttgac cctgcctagg     1200

atcaaagtca ccacctccca agatatgctc tcaataatgg agaaactgga gttctttgat     1260

ttctcctatg atctcaatct gtgtggcctg actgaagatc cagacctcca agtctcagca     1320

atgcagcacc agacagtcct ggagctcaca gagactggtg tggaggcggc agcagcctca     1380

gccatctctg tggccagaac cctgctggtg tttgaggtgc agcagccctt cctgtttgtt     1440

ctgtgggacc agcagcataa gtttcctgtc ttcatgggta gggtgtatga ccccagagcc     1500

tga                                                                   1503


<210>  15
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA18

<400>  15
atggccagca gactcaccct gctgaccctg ctcctcctgc tcctggctgg ggacagagcc       60

tcctccaacc ccaatgcaac ctcctccagc tcccaagacc ctgagtccct gcaagatagg      120

ggagaaggca aggttgccac tactgtcata agcaagatgc tgtttgttga acccatcttg      180

gaggtgtcca gtctccccac cacaaacagc accaccaact ctgccaccaa gatcactgcc      240

aataccacag atgaacccac cactcagccc acaactgagc ccaccaccca gccaaccata      300

cagcctacac agccaacaac ccagctgccc actgactccc caacccagcc taccactggc      360

agcttctgcc ctggtcctgt caccctctgc agtgacctgg aaagccatag cacagaggct      420

gtgctggggg atgctctggt ggacttctcc ctcaaactct accatgcttt ttctgcaatg      480

aagaaggtgg aaaccaacat ggccttcagc cccttctcca ttgccagcct cttgacccaa      540

gtgctcctgg gagctggaga gaacactaag actaatctgg agagcatcct ctcctacccc      600

aaagacttca cctgtgtgca ccaagccctg aagggcttca ccaccaaagg agtgacctct      660

gtctcccaga tcttccattc ccctgacctg gccataaggg acacctttgt gaatgcctct      720

aggaccctgt actccagctc tcctcgggtc ctcagcaaca actcagatgc caacctggag      780

ctcatcaaca cctgggtggc caaaaatacc aataacaaga tttcccgcct cctggattcc      840

ctgccctctg acacacgcct ggtgctcctg aatgccatct acctgagtgc caagtggaag      900

accacctttg atcccaagaa aaccagaatg gagcctttcc actttaagaa ttcagtcatt      960

aaagtgccca tgatgaattc caagaagtat cctgtggctc acttcattga ccagaccctc     1020

aaggccaagg taggtcagct ccagctgagc cacaacctca gcctggtgat cctggtcccc     1080

cagaacctga aacataggct ggaggacatg gaacaagcac tgtccccatc agtcttcaag     1140

gctatcatgg agaagctgga gatgagcaaa ttccagccca cactgctgac cttgcctagg     1200

atcaaggtca ccaccagcca agatatgctc tcaattatgg agaaactgga attctttgac     1260

ttttcctatg acctcaatct gtgtggcctg acagaagatc cagatctcca agtcagtgcc     1320

atgcagcacc agacagtgct ggagctgact gaaactgggg tggaggcagc ggcagcctca     1380

gccatttctg tggcaaggac cctgctggtg tttgaagtgc agcagccctt tctctttgtc     1440

ctgtgggatc agcagcacaa gtttccagtg ttcatgggcc gggtgtatga tccaagggcc     1500

tga                                                                   1503


<210>  16
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA19

<400>  16
atggcctccc ggctgaccct tctcaccctg ctcctgctgc ttctggctgg ggaccgggcc       60

agcagcaacc ccaatgctac cagctcttca tcacaagacc ctgagagcct gcaagacaga      120

ggagaaggca aggttgccac tactgtgatc agcaagatgc tcttcgtgga gcccatcctg      180

gaagtgtctt ctctgcccac aaccaactcc accacaaatt ctgccaccaa aatcacagcc      240

aataccactg atgaacccac cactcaaccc accacagagc caacaacaca gccaaccatc      300

cagcctaccc agcctaccac ccagcttcct acagacagcc caactcagcc cacaactggc      360

tccttctgcc ctgggcctgt caccctgtgc tctgacttgg aaagccacag caccgaggct      420

gtgctgggag atgctctggt ggacttttct ttgaagctct accacgcctt cagtgccatg      480

aagaaagtag agaccaacat ggcattcagc cccttttcca ttgcttccct gttgacccaa      540

gtgctccttg gagctggaga gaacactaaa accaatcttg agtccatcct ctcctacccc      600

aaagacttca cctgtgtgca ccaagcactg aaaggcttca caaccaaggg ggtgacctca      660

gtgtcccaga tcttccattc cccagacctg gccattaggg acacatttgt gaatgcaagc      720

agaactctgt acagctccag ccctagggtg ctgtccaaca attcagatgc caacttggag      780

ctcatcaaca cctgggtggc caaaaacaca aacaacaaga tctccagact cctggactcc      840

ctccccagtg acaccagact ggttctgctg aatgccatct acctgtcagc caagtggaag      900

accacctttg accccaagaa gacaaggatg gaaccattcc actttaagaa cagtgtcatc      960

aaagtgccca tgatgaacag caaaaagtac cctgtggccc acttcattga tcagaccctc     1020

aaggcaaagg tgggccagct gcagctctcc cacaacctca gccttgtgat tctggtcccc     1080

cagaacctga agcacagact ggaggacatg gaacaagccc tgtctccttc agtcttcaag     1140

gccatcatgg agaagctgga gatgtccaag ttccagccca ctctcctcac actgcctaga     1200

atcaaggtca ctacctctca agatatgctg agcatcatgg agaaactgga gttctttgat     1260

ttctcctatg acctcaacct gtgtggcctg acagaagatc cagatttgca agtttctgca     1320

atgcagcacc agacagtgct agagctgact gagactggtg tggaagctgc tgcagcctct     1380

gctatctctg tggcaagaac cttgctggtg tttgaggtgc agcagccctt cctgtttgtc     1440

ctgtgggacc agcaacacaa gtttccagtg ttcatgggca gagtgtatga tcccagagcc     1500

tga                                                                   1503


<210>  17
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized SERPING1 HA20

<400>  17
atggcatcca gactcacact gctcactctg ctgcttctgt tgctggctgg agaccgggcc       60

tccagcaacc ccaacgccac ttcttcctcc agtcaagatc ctgagagtct ccaagacaga      120

ggagaaggca aggttgctac cactgtgatt tccaagatgc tctttgtgga gcccatcttg      180

gaagtgagct ccctgcctac caccaattcc accacaaatt cagccaccaa aatcaccgcc      240

aacactacag atgagccaac cacccagccc acgacagagc ctacaactca gcccaccatc      300

cagcctactc aaccaacaac acagctcccc acagacagcc ccacccagcc aactactggc      360

tccttctgcc ctgggcccgt gaccctctgc agtgaccttg agagccacag caccgaggct      420

gtgctgggag atgctctggt ggacttttct ctgaagctgt accatgcttt ctctgcaatg      480

aagaaagtag agaccaacat ggccttcagt cccttttcca ttgccagcct gctgacccaa      540

gtgctcctgg gcgctgggga gaacacaaaa accaacctgg agtccatcct ctcctacccc      600

aaggatttca cctgtgtgca ccaagccctg aagggcttca caaccaaggg ggtcacctct      660

gtgtcccaga tcttccattc cccagacctg gccatcagag acaccttcgt gaatgcttcc      720

cgcaccctct acagcagctc tcctcgagtg ctatccaaca attctgatgc caatctggag      780

ctcatcaaca cctgggtggc aaagaataca aacaacaaga tcagccggct gctggactcc      840

ctcccttctg acacaaggct ggtcctcctg aatgccatct acctgtctgc caagtggaag      900

accacatttg atcccaaaaa gacaagaatg gaaccattcc actttaagaa ctccgtgatc      960

aaagtcccca tgatgaacag caagaagtac cctgtggccc acttcattga tcagaccctg     1020

aaagccaaag tgggccagct gcagctttcc cacaacctgt ccttggtcat cctggtgccc     1080

cagaacctca agcaccgcct ggaagatatg gaacaagcac tcagcccatc tgtcttcaag     1140

gccattatgg agaaactgga gatgtccaaa ttccagccca ctctcctcac cctgcccaga     1200

atcaaggtga ctaccagcca agacatgctg agcatcatgg agaagctcga gttctttgac     1260

ttctcctatg acctcaactt gtgtggcctg actgaggacc ctgatctgca agtcagtgcc     1320

atgcagcacc agacagtgtt ggagctgaca gaaactggtg tggaagctgc tgcagcctct     1380

gctatctcag tggctcggac cttgcttgtg tttgaggtgc agcaaccctt cctgtttgtc     1440

ctgtgggacc agcagcataa gtttccagtg ttcatgggcc gggtgtatga tccaagagcc     1500

tga                                                                   1503


<210>  18
<211>  218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3X CRM8

<400>  18
gggggaggct gctggtgaat attaaccaag gtcaccccag ttatcggagg agcaaacagg       60

ggctaagtcc accgggggag gctgctggtg aatattaacc aaggtcaccc cagttatcgg      120

aggagcaaac aggggctaag tccaccgggg gaggctgctg gtgaatatta accaaggtca      180

ccccagttat cggaggagca aacaggggct aagtccac                              218


<210>  19
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MVM Intron

<400>  19
ctaaggtaag ttggcgccgt ttaagggatg gttggttggt ggggtattaa tgtttaatta       60

ccttttttac aggcctg                                                      77


<210>  20
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SERPING1 exon1-intron1-partially exon2

<400>  20
ctgatttaca ggaactcaca ccagcgatca atcttcctta atttgtaact gggcagtgtc       60

ccgggccagc caatagctaa gactgccccc cccgcacccc accctccctg accctggggg      120

actctctact cagtctgcac tggagctgcc tggtgaccag aagtttggag taggtttggt      180

gctgggcagg ggtggggagt agggtggaaa gcatggagtg aagaggtcta gggagggggt      240

ctcctcaccc ccgccttcct gcccgccttg atctcggggg tctctatagg cttgcttcca      300

cctgggactt ctgcctcctc ctaccccagc ccctcccgcc tcaggcctgt tgtgctcagc      360

cccccaggac ctcccctccc ccacgcctct ggcctcattg tttggttaaa gcaggacccc      420

ctccccctcc caccacctcc cctccgactg aacagatgga cagagacccg ggcccacggg      480

gagaggaagg gccagccggt gccgggaaag ggaagcggtt tggggaaaac aaaacagagg      540

gaggagccag ggagaaggtg gccccaggag ggaggaggag ggaattcgct aagagggact      600

ggggcctgag acggaatggg ggcgggcccc gggcggggtg ggggcccctg ggctcccagg      660

gtgggagctg gctccgaggc tggctggctc cgcaggtccg ctgacgtcgc cgcccag         717


<210>  21
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGHpA

<400>  21
cctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc       60

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa      120

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg      180

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggaa            234


<210>  22
<211>  592
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE WT

<400>  22
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaagctga cgtcctttcc atggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210>  23
<211>  248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE3

<400>  23
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggtgtt                                                               248


<210>  24
<211>  602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPREmut6delATG

<400>  24
gataatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactttgtt       60

gctcctttta cgctttgtgg atacgctgct ttattgcctt tgtatcttgc tattgcttcc      120

cgtttggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct ttttgaggag      180

ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc      240

actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc      300

cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg      360

ctgttgggca ctgacaattc cgtggtgttg tcggggaaat catcgtcctt tccttggctg      420

ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc      480

ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt      540

cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc gcatcggact      600

ag                                                                     602


<210>  25
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRE4

<400>  25
gagttaatgt gtaatgagac ggggagaaaa caggagagcc cagaatgacc tggatgctga       60

tcactgaaca taccctaccc ccagtaaaac aaattcagaa aacagcttcc gcccgtcccc      120

tcccaatgga gggctctggc aggaaaagag gtgaataaga ggcttctacc agggtaaagg      180

ttgaaggcac ctggtcattt gatcacctta tcagttctag gcagtgatta gccaatattg      240

agtcagcagg ggcaatagcc ctggcccttg tctcactcct gttgggggtg ggggaggggg      300

agaggtacat tcccaggttc aaagcatttg ggtgaaatca gttaaataga tatcagaagc      360

ttttgtatct ttcacccttt tgccccccaa gcatactcgc tgagtatgtg gaacattcct      420

gagggt                                                                 426


<210>  26
<211>  267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRE6

<400>  26
aggggggccc ctggggctga cagggactgg aagctctgag ctggccagag ggatgttgca       60

atcctgccag ggtcttgtct atgctgtcct tttcacaacc atccccctac tgccaggctg      120

acacgtggtt gcgggggcac aaggccagcc aacctagagt ctgaggctag gcggaggaca      180

ccctccccac cagctgccag ggtcactggc ggtcaaaggc agctggtggg gaaggcattg      240

gactccagcc ttgggggacg gatgtag                                          267


<210>  27
<211>  233
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hTTR

<400>  27
aaatgaccta ttaagaatat ttcatagaac gaatgttccg atgctctaat ctctctagac       60

aaggttcata tttgtatggg ttacttattc tctctttgtt gactaagtca ataatcagaa      120

tcagcaggtt tgcagtcaga ttggcaggga taagcagcct agctcaggag aagtgagtat      180

aaaagcccca ggctgggagc agccatcaca gaagtccact cattcttggc agg             233


<210>  28
<211>  222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mod_mTTR

<400>  28
gtctgtctgc acatttcgta gagcgagtgt tccgatactc taatctccct aggcaaggtt       60

catattgact taggttactt attctccttt tgttgactaa gtcaataatc agaatccagc      120

aggtttggag tcagcttggc agggatcagc agccttgggt tggaaggagg gggtataaaa      180

gccccttcac caggagaagc cgtcacacag atccacaagc tc                         222


<210>  29
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT mTTR

<400>  29
ggtagctcta gaggatcccc gtctgtctgc acatttcgta gagcgagtgt tccgatactc       60

taatctccct aggcaaggtt catatttgtg taggttactt attctccttt tgttgactaa      120

gtcaataatc agaatcagca ggtttggagt cagcttggca gggatcagca gcctgggttg      180

gaaggagggg gtataaaagc cccttcacca ggagaagccg tcacacaga                  229


