                         SEQUENCE LISTING

<110>  The Trustees of The University of Pennsylvania
 
<120>  COMPOSITIONS FOR DRG-SPECIFIC REDUCTION OF TRANSGENE EXPRESSION

<130>  UPN-20-9316.PCT

<150>  US 63/043,600
<151>  2020-06-24

<150>  US 63/038,514
<151>  2020-06-12

<150>  US 63/023,602
<151>  2020-05-12

<150>  US 63/005,894
<151>  2020-04-06

<150>  US 62/972,404
<151>  2020-02-10

<150>  PCT/US19/67872
<151>  2019-12-20

<150>  US 62/934,915
<151>  2019-11-13

<150>  US 62/924,970
<151>  2019-10-23

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-183 target

<400>  1
agtgaattct accagtgcca ta                                                22


<210>  2
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mirR-96 target

<400>  2
agcaaaaatg tgctagtgcc aaa                                               23


<210>  3
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miR-182 target

<400>  3
agtgtgagtt ctaccattgc caaa                                              24


<210>  4
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miR-145 target

<400>  4
agggattcct gggaaaactg gac                                               23


<210>  5
<211>  4
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Spacer (i)

<400>  5
ggat                                                                     4


<210>  6
<211>  6
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Spacer (ii)

<400>  6
cacgtg                                                                   6


<210>  7
<211>  6
<212>  DNA
<213>  Artificial sequence

<220>
<223>  spacer iii

<400>  7
gcatgc                                                                   6


<210>  8
<211>  2211
<212>  DNA
<213>  adeno-associated virus hu68


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  8
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc agt         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gaa ggc att cgc gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro           
            20                  25                  30                    

aag gca aat caa caa cat caa gac aac gct cgg ggt ctt gtg ctt ccg        144
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggt tac aaa tac ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg        192
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gaa gca gac gcg gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aag gcc gga gac aac ccg tac ctc aag tac aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttc cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro           
        115                 120                 125                       

ctt ggt ctg gtt gag gaa gcg gct aag acg gct cct gga aag aag agg        432
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

cct gta gag cag tct cct cag gaa ccg gac tcc tcc gtg ggt att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly           
145                 150                 155                 160           

aaa tcg ggt gca cag ccc gct aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac aca gag tca gtc ccc gac cct caa cca atc gga gaa cct ccc        576
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro           
            180                 185                 190                   

gca gcc ccc tca ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc        624
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca gtg gca gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc        672
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser           
    210                 215                 220                           

tcg gga aat tgg cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aat cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc aac agc aca tct gga gga tct tca aat gac aac        816
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn           
            260                 265                 270                   

gcc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac aga        864
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg           
        275                 280                 285                       

ttc cac tgc cac ttc tca cca cgt gac tgg caa aga ctc atc aac aac        912
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn           
    290                 295                 300                           

aac tgg gga ttc cgg cct aag cga ctc aac ttc aag ctc ttc aac att        960
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile           
305                 310                 315                 320           

cag gtc aaa gag gtt acg gac aac aat gga gtc aag acc atc gct aat       1008
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn           
                325                 330                 335               

aac ctt acc agc acg gtc cag gtc ttc acg gac tca gac tat cag ctc       1056
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu           
            340                 345                 350                   

ccg tac gtg ctc ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca       1104
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro           
        355                 360                 365                       

gcg gac gtt ttc atg att cct cag tac ggg tat cta acg ctt aat gat       1152
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp           
    370                 375                 380                           

gga agc caa gcc gtg ggt cgt tcg tcc ttt tac tgc ctg gaa tat ttc       1200
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe           
385                 390                 395                 400           

ccg tcg caa atg cta aga acg ggt aac aac ttc cag ttc agc tac gag       1248
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu           
                405                 410                 415               

ttt gag aac gta cct ttc cat agc agc tat gct cac agc caa agc ctg       1296
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu           
            420                 425                 430                   

gac cga ctc atg aat cca ctc atc gac caa tac ttg tac tat ctc tca       1344
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser           
        435                 440                 445                       

aag act att aac ggt tct gga cag aat caa caa acg cta aaa ttc agt       1392
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser           
    450                 455                 460                           

gtg gcc gga ccc agc aac atg gct gtc cag gga aga aac tac ata cct       1440
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro           
465                 470                 475                 480           

gga ccc agc tac cga caa caa cgt gtc tca acc act gtg act caa aac       1488
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn           
                485                 490                 495               

aac aac agc gaa ttt gct tgg cct gga gct tct tct tgg gct ctc aat       1536
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn           
            500                 505                 510                   

gga cgt aat agc ttg atg aat cct gga cct gct atg gcc agc cac aaa       1584
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys           
        515                 520                 525                       

gaa gga gag gac cgt ttc ttt cct ttg tct gga tct tta att ttt ggc       1632
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly           
    530                 535                 540                           

aaa caa gga act gga aga gac aac gtg gat gcg gac aaa gtc atg ata       1680
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile           
545                 550                 555                 560           

acc aac gaa gaa gaa att aaa act acc aac cca gta gca acg gag tcc       1728
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser           
                565                 570                 575               

tat gga caa gtg gcc aca aac cac cag agt gcc caa gca cag gcg cag       1776
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln           
            580                 585                 590                   

acc ggc tgg gtt caa aac caa gga ata ctt ccg ggt atg gtt tgg cag       1824
Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gat gtg tac ctg caa gga ccc att tgg gcc aaa att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gac ggc aac ttt cac cct tct ccg ctg atg gga ggg ttt gga atg       1920
Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac aca cct gta cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

gat cct cca acg gct ttc aac aag gac aag ctg aac tct ttc atc acc       2016
Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr           
            660                 665                 670                   

cag tat tct act ggc caa gtc agc gtg gag att gag tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aag gaa aac agc aag cgc tgg aac ccg gag atc cag tac act tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat tac aag tct aat aat gtt gaa ttt gct gtt aat act gaa ggt gtt       2160
Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val           
705                 710                 715                 720           

tat tct gaa ccc cgc ccc att ggc acc aga tac ctg act cgt aat ctg       2208
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu           
                725                 730                 735               

taa                                                                   2211


<210>  9
<211>  736
<212>  PRT
<213>  adeno-associated virus hu68

<400>  9

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  10
<211>  3198
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.eGFP.miR145.rBG.ITR


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' - AAV2 - ITR

<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5' - AAV2 - ITR

<220>
<221>  promoter
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (1979)..(2698)
<223>  eGFP gene

<220>
<221>  misc_feature
<222>  (2705)..(2727)
<223>  miR145

<220>
<221>  misc_feature
<222>  (2728)..(2731)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2732)..(2754)
<223>  miR145

<220>
<221>  misc_feature
<222>  (2755)..(2760)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2761)..(2783)
<223>  miR145

<220>
<221>  misc_feature
<222>  (2784)..(2789)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2790)..(2812)
<223>  miR145

<220>
<221>  misc_feature
<222>  (2981)..(3198)
<223>  3' ITR

<400>  10
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattacttaa tacgactcac tataggctag taatacgact cactatagat     1980

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2040

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2100

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2160

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     2220

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     2280

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     2340

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     2400

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     2460

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     2520

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2580

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     2640

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaagg     2700

taccagggat tcctgggaaa actggacgga tagggattcc tgggaaaact ggaccacgtg     2760

agggattcct gggaaaactg gacgcatgca gggattcctg ggaaaactgg acgcggccgc     2820

ctcgaggacg gggtgaacta cgcctgagga tccgatcttt ttccctctgc caaaaattat     2880

ggggacatca tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc     2940

attgcaatag tgtgttggaa ttttttgtgt ctctcactcg gaagcaattc gttgatctga     3000

atttcgacca cccataatac ccattaccct ggtagataag tagcatggcg ggttaatcat     3060

taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     3120

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     3180

gagcgagcga gcgcgcag                                                   3198


<210>  11
<211>  3202
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.eGFP.miR182.rGB.ITR


<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5' ITR (AAV2)

<220>
<221>  misc_feature
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  misc_feature
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (958)..(1930)
<223>  chicken beta-actin intron

<220>
<221>  misc_feature
<222>  (1979)..(2698)
<223>  eGFP coding sequence

<220>
<221>  misc_feature
<222>  (2705)..(2728)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2729)..(2732)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2733)..(2756)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2757)..(2760)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2763)..(2786)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2787)..(2792)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2793)..(2816)
<223>  miR182

<220>
<221>  polyA_signal
<222>  (2858)..(2984)

<220>
<221>  misc_feature
<222>  (3073)..(3202)
<223>  3' ITR

<400>  11
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattacttaa tacgactcac tataggctag taatacgact cactatagat     1980

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2040

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2100

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2160

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     2220

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     2280

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     2340

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     2400

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     2460

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     2520

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2580

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     2640

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaagg     2700

taccagtgtg agttctacca ttgccaaagg atagtgtgag ttctaccatt gccaaacacg     2760

tgagtgtgag ttctaccatt gccaaagcat gcagtgtgag ttctaccatt gccaaagcgg     2820

ccgcctcgag gacggggtga actacgcctg aggatccgat ctttttccct ctgccaaaaa     2880

ttatggggac atcatgaagc cccttgagca tctgacttct ggctaataaa ggaaatttat     2940

tttcattgca atagtgtgtt ggaatttttt gtgtctctca ctcggaagca attcgttgat     3000

ctgaatttcg accacccata atacccatta ccctggtaga taagtagcat ggcgggttaa     3060

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3120

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3180

cagtgagcga gcgagcgcgc ag                                              3202


<210>  12
<211>  3198
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.eGFP.miRNA96.rBG.ITR


<220>
<221>  misc_feature
<222>  (1979)..(2699)
<223>  eGFP coding sequence

<220>
<221>  misc_feature
<222>  (2705)..(2727)
<223>  miR96

<220>
<221>  misc_feature
<222>  (2728)..(2731)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2732)..(2754)
<223>  miR96

<220>
<221>  misc_feature
<222>  (2755)..(2760)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2761)..(2783)
<223>  miR96

<220>
<221>  misc_feature
<222>  (2784)..(2789)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2790)..(2812)
<223>  miR96

<400>  12
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattacttaa tacgactcac tataggctag taatacgact cactatagat     1980

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2040

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2100

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2160

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     2220

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     2280

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     2340

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     2400

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     2460

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     2520

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2580

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     2640

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaagg     2700

taccagcaaa aatgtgctag tgccaaagga tagcaaaaat gtgctagtgc caaacacgtg     2760

agcaaaaatg tgctagtgcc aaagcatgca gcaaaaatgt gctagtgcca aagcggccgc     2820

ctcgaggacg gggtgaacta cgcctgagga tccgatcttt ttccctctgc caaaaattat     2880

ggggacatca tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc     2940

attgcaatag tgtgttggaa ttttttgtgt ctctcactcg gaagcaattc gttgatctga     3000

atttcgacca cccataatac ccattaccct ggtagataag tagcatggcg ggttaatcat     3060

taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     3120

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     3180

gagcgagcga gcgcgcag                                                   3198


<210>  13
<211>  3194
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.eGFP.miRNA183.rBG.ITR


<220>
<221>  misc_feature
<222>  (1979)..(2698)
<223>  eGFP coding sequence

<220>
<221>  misc_feature
<222>  (2705)..(2726)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (2727)..(2730)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2731)..(2752)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (2753)..(2758)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2781)..(2786)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2787)..(2808)
<223>  miRNA183

<400>  13
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattacttaa tacgactcac tataggctag taatacgact cactatagat     1980

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2040

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2100

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2160

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     2220

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     2280

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     2340

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     2400

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     2460

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     2520

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2580

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     2640

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaagg     2700

taccagtgaa ttctaccagt gccataggat agtgaattct accagtgcca tacacgtgag     2760

tgaattctac cagtgccata gcatgcagtg aattctacca gtgccatagc ggccgcctcg     2820

aggacggggt gaactacgcc tgaggatccg atctttttcc ctctgccaaa aattatgggg     2880

acatcatgaa gccccttgag catctgactt ctggctaata aaggaaattt attttcattg     2940

caatagtgtg ttggaatttt ttgtgtctct cactcggaag caattcgttg atctgaattt     3000

cgaccaccca taatacccat taccctggta gataagtagc atggcgggtt aatcattaac     3060

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     3120

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     3180

gagcgagcgc gcag                                                       3194


<210>  14
<211>  4300
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.hIDUAcoV1.rBG.ITR


<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  misc_feature
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  misc_feature
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (836)..(839)
<223>  TATA

<220>
<221>  misc_feature
<222>  (958)..(1930)
<223>  chicken beta-actin intron

<220>
<221>  CDS
<222>  (1943)..(3901)
<223>  hIDUAcoV1

<220>
<221>  misc_feature
<222>  (3908)..(3922)
<223>  3UTR insertion site

<220>
<221>  misc_feature
<222>  (3956)..(4082)
<223>  Rabbit globin poly A

<220>
<221>  misc_feature
<222>  (4171)..(4300)
<223>  3' ITR

<400>  14
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattcagcca cc atg agg cct ctc aga cct aga gct gct ctg      1972
                         Met Arg Pro Leu Arg Pro Arg Ala Ala Leu          
                         1               5                   10           

ctg gca ctg ctg gct tct ctg ctt gct gct cct cct gtg gct cct gcc       2020
Leu Ala Leu Leu Ala Ser Leu Leu Ala Ala Pro Pro Val Ala Pro Ala           
                15                  20                  25                

gaa gct cct cat ctg gtg cac gtg gat gcc gcc aga gca ctg tgg ccc       2068
Glu Ala Pro His Leu Val His Val Asp Ala Ala Arg Ala Leu Trp Pro           
            30                  35                  40                    

ctg aga aga ttt tgg cgg agc acc ggc ttt tgc cct cca ctg cct cat       2116
Leu Arg Arg Phe Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His           
        45                  50                  55                        

tct cag gcc gac cag tac gtg ctg agc tgg gac cag caa ctg aac ctg       2164
Ser Gln Ala Asp Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu           
    60                  65                  70                            

gcc tac gtg gga gcc gtg cct cac aga ggc att aag caa gtg cgg acc       2212
Ala Tyr Val Gly Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr           
75                  80                  85                  90            

cac tgg ctg ctg gaa ctg gtc aca aca aga ggc agc aca ggc aga ggc       2260
His Trp Leu Leu Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly           
                95                  100                 105               

ctg agc tac aac ttc acc cac ctg gac ggc tac ctg gac ctg ctg aga       2308
Leu Ser Tyr Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg           
            110                 115                 120                   

gag aat cag ctg ctg cct ggc ttc gag ctg atg ggc tct gcc tct ggc       2356
Glu Asn Gln Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly           
        125                 130                 135                       

cac ttc acc gac ttc gag gac aag cag cag gtt ttc gag tgg aag gac       2404
His Phe Thr Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp           
    140                 145                 150                           

ctg gtg tcc agc ctg gcc aga cgg tac atc ggc aga tac gga ctg gcc       2452
Leu Val Ser Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala           
155                 160                 165                 170           

cac gtg tcc aag tgg aac ttc gag acc tgg aac gag ccc gac cac cac       2500
His Val Ser Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His           
                175                 180                 185               

gac ttc gac aac gtg tca atg acc atg cag ggc ttt ctg aac tac tac       2548
Asp Phe Asp Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr           
            190                 195                 200                   

gac gcc tgc agc gag ggc ctg aga gct gct tct cct gct ctg aga ctt       2596
Asp Ala Cys Ser Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu           
        205                 210                 215                       

ggc ggc cct ggc gac tct ttt cac acc cct cca aga agc cct ctg tcc       2644
Gly Gly Pro Gly Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser           
    220                 225                 230                           

tgg gga ctg ctg aga cac tgt cac gac ggc acc aat ttc ttc acc ggc       2692
Trp Gly Leu Leu Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly           
235                 240                 245                 250           

gag gct ggc gtg cgg ctg gat tat atc agc ctg cac aga aag ggc gcc       2740
Glu Ala Gly Val Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala           
                255                 260                 265               

aga agc agc atc agc atc ctg gaa caa gag aag gtg gtg gcc cag cag       2788
Arg Ser Ser Ile Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln           
            270                 275                 280                   

atc aga cag ctg ttc ccc aag ttc gcc gac aca ccc atc tac aac gac       2836
Ile Arg Gln Leu Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp           
        285                 290                 295                       

gag gcc gat cct ctc gtt ggc tgg tca ctt cct cag cct tgg aga gcc       2884
Glu Ala Asp Pro Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala           
    300                 305                 310                           

gat gtg acc tat gcc gcc atg gtg gtc aaa gtg atc gcc cag cac cag       2932
Asp Val Thr Tyr Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln           
315                 320                 325                 330           

aat ctg ctg ctc gcc aat acc acc agc gcc ttt cca tac gct ctg ctg       2980
Asn Leu Leu Leu Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu           
                335                 340                 345               

agc aac gac aac gcc ttc ctg agc tat cac cct cat cct ttc gct cag       3028
Ser Asn Asp Asn Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln           
            350                 355                 360                   

cgg acc ctg acc gcc aga ttc caa gtg aac aac acc cgg cct cca cac       3076
Arg Thr Leu Thr Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His           
        365                 370                 375                       

gtg cag ctg ctg aga aaa cca gtg ctg aca gcc atg ggc ctg ctc gcc       3124
Val Gln Leu Leu Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala           
    380                 385                 390                           

ctg ctg gac gaa gaa caa ctg tgg gcc gaa gtg tcc cag gcc gga aca       3172
Leu Leu Asp Glu Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr           
395                 400                 405                 410           

gtg ctg gat agc aat cac aca gtg ggc gtg ctg gcc tcc gct cat aga       3220
Val Leu Asp Ser Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg           
                415                 420                 425               

cct caa gga cca gcc gat gct tgg agg gct gcc gtg ctg atc tac gcc       3268
Pro Gln Gly Pro Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala           
            430                 435                 440                   

agc gac gat aca agg gct cac ccc aac aga tcc gtg gcc gtg aca ctg       3316
Ser Asp Asp Thr Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu           
        445                 450                 455                       

aga ctg aga ggc gtt cca cca gga cct ggc ctg gtg tac gtg acc aga       3364
Arg Leu Arg Gly Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg           
    460                 465                 470                           

tac ctg gac aac ggc ctg tgc agc cct gat ggc gaa tgg cgt aga cta       3412
Tyr Leu Asp Asn Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu           
475                 480                 485                 490           

ggc aga cct gtg ttt cct acc gcc gag cag ttc aga cgg atg aga gcc       3460
Gly Arg Pro Val Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala           
                495                 500                 505               

gct gaa gat ccc gtg gct gct gct cca aga cct ctt cca gct ggt ggc       3508
Ala Glu Asp Pro Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly           
            510                 515                 520                   

aga ctg act ctg agg cct gca ctc aga ctg cct agt ctg ctg ctg gtg       3556
Arg Leu Thr Leu Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val           
        525                 530                 535                       

cac gtc tgt gcc aga cct gag aag cct cct ggc caa gtg aca aga ctg       3604
His Val Cys Ala Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu           
    540                 545                 550                           

agg gcc ctg cca ctg aca cag gga cag ctg gtt ctt gtt tgg agc gac       3652
Arg Ala Leu Pro Leu Thr Gln Gly Gln Leu Val Leu Val Trp Ser Asp           
555                 560                 565                 570           

gag cac gtg ggc agc aag tgt ctg tgg acc tac gag atc cag ttc agc       3700
Glu His Val Gly Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser           
                575                 580                 585               

cag gac ggc aag gcc tac aca ccc gtg tct aga aag cct agc acc ttc       3748
Gln Asp Gly Lys Ala Tyr Thr Pro Val Ser Arg Lys Pro Ser Thr Phe           
            590                 595                 600                   

aac ctg ttc gtg ttc agc ccc gat aca ggc gcc gtg tct ggc agc tat       3796
Asn Leu Phe Val Phe Ser Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr           
        605                 610                 615                       

aga gtc aga gcc ctg gac tac tgg gcc aga cca gga cca ttt tct gac       3844
Arg Val Arg Ala Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp           
    620                 625                 630                           

ccc gtg cct tac ctg gaa gtg ccc gtt cct aga ggc cct cct tct cct       3892
Pro Val Pro Tyr Leu Glu Val Pro Val Pro Arg Gly Pro Pro Ser Pro           
635                 640                 645                 650           

gga aat ccc tgataaggta ccatacctag gctcgaggac ggggtgaact               3941
Gly Asn Pro                                                               
                                                                          

acgcctgagg atccgatctt tttccctctg ccaaaaatta tggggacatc atgaagcccc     4001

ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata gtgtgttgga     4061

attttttgtg tctctcactc ggaagcaatt cgttgatctg aatttcgacc acccataata     4121

cccattaccc tggtagataa gtagcatggc gggttaatca ttaactacaa ggaaccccta     4181

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     4241

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag      4300


<210>  15
<211>  653
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  16
<211>  4403
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.hIDUAcoV1.miR183.ITR


<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  misc_feature
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  misc_feature
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (836)..(839)
<223>  TATA

<220>
<221>  misc_feature
<222>  (958)..(1930)
<223>  chicken beta-actin intron

<220>
<221>  CDS
<222>  (1943)..(3901)

<220>
<221>  misc_feature
<222>  (3914)..(3935)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (3936)..(3939)
<223>  spacer

<220>
<221>  misc_feature
<222>  (3940)..(3961)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (3962)..(3967)
<223>  spacer

<220>
<221>  misc_feature
<222>  (3968)..(3989)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (3990)..(3995)
<223>  spacer

<220>
<221>  misc_feature
<222>  (3996)..(4017)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (4059)..(4185)
<223>  Rabbit globin poly A

<220>
<221>  misc_feature
<222>  (4274)..(4403)
<223>  3' ITR

<400>  16
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattcagcca cc atg agg cct ctc aga cct aga gct gct ctg      1972
                         Met Arg Pro Leu Arg Pro Arg Ala Ala Leu          
                         1               5                   10           

ctg gca ctg ctg gct tct ctg ctt gct gct cct cct gtg gct cct gcc       2020
Leu Ala Leu Leu Ala Ser Leu Leu Ala Ala Pro Pro Val Ala Pro Ala           
                15                  20                  25                

gaa gct cct cat ctg gtg cac gtg gat gcc gcc aga gca ctg tgg ccc       2068
Glu Ala Pro His Leu Val His Val Asp Ala Ala Arg Ala Leu Trp Pro           
            30                  35                  40                    

ctg aga aga ttt tgg cgg agc acc ggc ttt tgc cct cca ctg cct cat       2116
Leu Arg Arg Phe Trp Arg Ser Thr Gly Phe Cys Pro Pro Leu Pro His           
        45                  50                  55                        

tct cag gcc gac cag tac gtg ctg agc tgg gac cag caa ctg aac ctg       2164
Ser Gln Ala Asp Gln Tyr Val Leu Ser Trp Asp Gln Gln Leu Asn Leu           
    60                  65                  70                            

gcc tac gtg gga gcc gtg cct cac aga ggc att aag caa gtg cgg acc       2212
Ala Tyr Val Gly Ala Val Pro His Arg Gly Ile Lys Gln Val Arg Thr           
75                  80                  85                  90            

cac tgg ctg ctg gaa ctg gtc aca aca aga ggc agc aca ggc aga ggc       2260
His Trp Leu Leu Glu Leu Val Thr Thr Arg Gly Ser Thr Gly Arg Gly           
                95                  100                 105               

ctg agc tac aac ttc acc cac ctg gac ggc tac ctg gac ctg ctg aga       2308
Leu Ser Tyr Asn Phe Thr His Leu Asp Gly Tyr Leu Asp Leu Leu Arg           
            110                 115                 120                   

gag aat cag ctg ctg cct ggc ttc gag ctg atg ggc tct gcc tct ggc       2356
Glu Asn Gln Leu Leu Pro Gly Phe Glu Leu Met Gly Ser Ala Ser Gly           
        125                 130                 135                       

cac ttc acc gac ttc gag gac aag cag cag gtt ttc gag tgg aag gac       2404
His Phe Thr Asp Phe Glu Asp Lys Gln Gln Val Phe Glu Trp Lys Asp           
    140                 145                 150                           

ctg gtg tcc agc ctg gcc aga cgg tac atc ggc aga tac gga ctg gcc       2452
Leu Val Ser Ser Leu Ala Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala           
155                 160                 165                 170           

cac gtg tcc aag tgg aac ttc gag acc tgg aac gag ccc gac cac cac       2500
His Val Ser Lys Trp Asn Phe Glu Thr Trp Asn Glu Pro Asp His His           
                175                 180                 185               

gac ttc gac aac gtg tca atg acc atg cag ggc ttt ctg aac tac tac       2548
Asp Phe Asp Asn Val Ser Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr           
            190                 195                 200                   

gac gcc tgc agc gag ggc ctg aga gct gct tct cct gct ctg aga ctt       2596
Asp Ala Cys Ser Glu Gly Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu           
        205                 210                 215                       

ggc ggc cct ggc gac tct ttt cac acc cct cca aga agc cct ctg tcc       2644
Gly Gly Pro Gly Asp Ser Phe His Thr Pro Pro Arg Ser Pro Leu Ser           
    220                 225                 230                           

tgg gga ctg ctg aga cac tgt cac gac ggc acc aat ttc ttc acc ggc       2692
Trp Gly Leu Leu Arg His Cys His Asp Gly Thr Asn Phe Phe Thr Gly           
235                 240                 245                 250           

gag gct ggc gtg cgg ctg gat tat atc agc ctg cac aga aag ggc gcc       2740
Glu Ala Gly Val Arg Leu Asp Tyr Ile Ser Leu His Arg Lys Gly Ala           
                255                 260                 265               

aga agc agc atc agc atc ctg gaa caa gag aag gtg gtg gcc cag cag       2788
Arg Ser Ser Ile Ser Ile Leu Glu Gln Glu Lys Val Val Ala Gln Gln           
            270                 275                 280                   

atc aga cag ctg ttc ccc aag ttc gcc gac aca ccc atc tac aac gac       2836
Ile Arg Gln Leu Phe Pro Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp           
        285                 290                 295                       

gag gcc gat cct ctc gtt ggc tgg tca ctt cct cag cct tgg aga gcc       2884
Glu Ala Asp Pro Leu Val Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala           
    300                 305                 310                           

gat gtg acc tat gcc gcc atg gtg gtc aaa gtg atc gcc cag cac cag       2932
Asp Val Thr Tyr Ala Ala Met Val Val Lys Val Ile Ala Gln His Gln           
315                 320                 325                 330           

aat ctg ctg ctc gcc aat acc acc agc gcc ttt cca tac gct ctg ctg       2980
Asn Leu Leu Leu Ala Asn Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu           
                335                 340                 345               

agc aac gac aac gcc ttc ctg agc tat cac cct cat cct ttc gct cag       3028
Ser Asn Asp Asn Ala Phe Leu Ser Tyr His Pro His Pro Phe Ala Gln           
            350                 355                 360                   

cgg acc ctg acc gcc aga ttc caa gtg aac aac acc cgg cct cca cac       3076
Arg Thr Leu Thr Ala Arg Phe Gln Val Asn Asn Thr Arg Pro Pro His           
        365                 370                 375                       

gtg cag ctg ctg aga aaa cca gtg ctg aca gcc atg ggc ctg ctc gcc       3124
Val Gln Leu Leu Arg Lys Pro Val Leu Thr Ala Met Gly Leu Leu Ala           
    380                 385                 390                           

ctg ctg gac gaa gaa caa ctg tgg gcc gaa gtg tcc cag gcc gga aca       3172
Leu Leu Asp Glu Glu Gln Leu Trp Ala Glu Val Ser Gln Ala Gly Thr           
395                 400                 405                 410           

gtg ctg gat agc aat cac aca gtg ggc gtg ctg gcc tcc gct cat aga       3220
Val Leu Asp Ser Asn His Thr Val Gly Val Leu Ala Ser Ala His Arg           
                415                 420                 425               

cct caa gga cca gcc gat gct tgg agg gct gcc gtg ctg atc tac gcc       3268
Pro Gln Gly Pro Ala Asp Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala           
            430                 435                 440                   

agc gac gat aca agg gct cac ccc aac aga tcc gtg gcc gtg aca ctg       3316
Ser Asp Asp Thr Arg Ala His Pro Asn Arg Ser Val Ala Val Thr Leu           
        445                 450                 455                       

aga ctg aga ggc gtt cca cca gga cct ggc ctg gtg tac gtg acc aga       3364
Arg Leu Arg Gly Val Pro Pro Gly Pro Gly Leu Val Tyr Val Thr Arg           
    460                 465                 470                           

tac ctg gac aac ggc ctg tgc agc cct gat ggc gaa tgg cgt aga cta       3412
Tyr Leu Asp Asn Gly Leu Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu           
475                 480                 485                 490           

ggc aga cct gtg ttt cct acc gcc gag cag ttc aga cgg atg aga gcc       3460
Gly Arg Pro Val Phe Pro Thr Ala Glu Gln Phe Arg Arg Met Arg Ala           
                495                 500                 505               

gct gaa gat ccc gtg gct gct gct cca aga cct ctt cca gct ggt ggc       3508
Ala Glu Asp Pro Val Ala Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly           
            510                 515                 520                   

aga ctg act ctg agg cct gca ctc aga ctg cct agt ctg ctg ctg gtg       3556
Arg Leu Thr Leu Arg Pro Ala Leu Arg Leu Pro Ser Leu Leu Leu Val           
        525                 530                 535                       

cac gtc tgt gcc aga cct gag aag cct cct ggc caa gtg aca aga ctg       3604
His Val Cys Ala Arg Pro Glu Lys Pro Pro Gly Gln Val Thr Arg Leu           
    540                 545                 550                           

agg gcc ctg cca ctg aca cag gga cag ctg gtt ctt gtt tgg agc gac       3652
Arg Ala Leu Pro Leu Thr Gln Gly Gln Leu Val Leu Val Trp Ser Asp           
555                 560                 565                 570           

gag cac gtg ggc agc aag tgt ctg tgg acc tac gag atc cag ttc agc       3700
Glu His Val Gly Ser Lys Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser           
                575                 580                 585               

cag gac ggc aag gcc tac aca ccc gtg tct aga aag cct agc acc ttc       3748
Gln Asp Gly Lys Ala Tyr Thr Pro Val Ser Arg Lys Pro Ser Thr Phe           
            590                 595                 600                   

aac ctg ttc gtg ttc agc ccc gat aca ggc gcc gtg tct ggc agc tat       3796
Asn Leu Phe Val Phe Ser Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr           
        605                 610                 615                       

aga gtc aga gcc ctg gac tac tgg gcc aga cca gga cca ttt tct gac       3844
Arg Val Arg Ala Leu Asp Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp           
    620                 625                 630                           

ccc gtg cct tac ctg gaa gtg ccc gtt cct aga ggc cct cct tct cct       3892
Pro Val Pro Tyr Leu Glu Val Pro Val Pro Arg Gly Pro Pro Ser Pro           
635                 640                 645                 650           

gga aat ccc tgataaggta ccagtgaatt ctaccagtgc cataggatag               3941
Gly Asn Pro                                                               
                                                                          

tgaattctac cagtgccata cacgtgagtg aattctacca gtgccatagc atgcagtgaa     4001

ttctaccagt gccatagcgg ccgcctcgag gacggggtga actacgcctg aggatccgat     4061

ctttttccct ctgccaaaaa ttatggggac atcatgaagc cccttgagca tctgacttct     4121

ggctaataaa ggaaatttat tttcattgca atagtgtgtt ggaatttttt gtgtctctca     4181

ctcggaagca attcgttgat ctgaatttcg accacccata atacccatta ccctggtaga     4241

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     4301

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     4361

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag                        4403


<210>  17
<211>  653
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  17

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  18
<211>  2211
<212>  DNA
<213>  adeno-associated virus 9


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  18
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctt agt         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gaa gga att cgc gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro           
            20                  25                  30                    

aag gca aat caa caa cat caa gac aac gct cga ggt ctt gtg ctt ccg        144
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggt tac aaa tac ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg        192
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gca gca gac gcg gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aag gcc gga gac aac ccg tac ctc aag tac aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttc cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro           
        115                 120                 125                       

ctt ggt ctg gtt gag gaa gcg gct aag acg gct cct gga aag aag agg        432
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

cct gta gag cag tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly           
145                 150                 155                 160           

aaa tcg ggt gca cag ccc gct aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac aca gag tca gtc cca gac cct caa cca atc gga gaa cct ccc        576
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro           
            180                 185                 190                   

gca gcc ccc tca ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc        624
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca gtg gca gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc        672
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser           
    210                 215                 220                           

tcg gga aat tgg cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aat cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc aac agc aca tct gga gga tct tca aat gac aac        816
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn           
            260                 265                 270                   

gcc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac aga        864
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg           
        275                 280                 285                       

ttc cac tgc cac ttc tca cca cgt gac tgg cag cga ctc atc aac aac        912
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn           
    290                 295                 300                           

aac tgg gga ttc cgg cct aag cga ctc aac ttc aag ctc ttc aac att        960
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile           
305                 310                 315                 320           

cag gtc aaa gag gtt acg gac aac aat gga gtc aag acc atc gcc aat       1008
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn           
                325                 330                 335               

aac ctt acc agc acg gtc cag gtc ttc acg gac tca gac tat cag ctc       1056
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu           
            340                 345                 350                   

ccg tac gtg ctc ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca       1104
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro           
        355                 360                 365                       

gcg gac gtt ttc atg att cct cag tac ggg tat ctg acg ctt aat gat       1152
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp           
    370                 375                 380                           

gga agc cag gcc gtg ggt cgt tcg tcc ttt tac tgc ctg gaa tat ttc       1200
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe           
385                 390                 395                 400           

ccg tcg caa atg cta aga acg ggt aac aac ttc cag ttc agc tac gag       1248
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu           
                405                 410                 415               

ttt gag aac gta cct ttc cat agc agc tac gct cac agc caa agc ctg       1296
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu           
            420                 425                 430                   

gac cga cta atg aat cca ctc atc gac caa tac ttg tac tat ctc tca       1344
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser           
        435                 440                 445                       

aag act att aac ggt tct gga cag aat caa caa acg cta aaa ttc agt       1392
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser           
    450                 455                 460                           

gtg gcc gga ccc agc aac atg gct gtc cag gga aga aac tac ata cct       1440
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro           
465                 470                 475                 480           

gga ccc agc tac cga caa caa cgt gtc tca acc act gtg act caa aac       1488
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn           
                485                 490                 495               

aac aac agc gaa ttt gct tgg cct gga gct tct tct tgg gct ctc aat       1536
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn           
            500                 505                 510                   

gga cgt aat agc ttg atg aat cct gga cct gct atg gcc agc cac aaa       1584
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys           
        515                 520                 525                       

gaa gga gag gac cgt ttc ttt cct ttg tct gga tct tta att ttt ggc       1632
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly           
    530                 535                 540                           

aaa caa gga act gga aga gac aac gtg gat gcg gac aaa gtc atg ata       1680
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile           
545                 550                 555                 560           

acc aac gaa gaa gaa att aaa act act aac ccg gta gca acg gag tcc       1728
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser           
                565                 570                 575               

tat gga caa gtg gcc aca aac cac cag agt gcc caa gca cag gcg cag       1776
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln           
            580                 585                 590                   

acc ggc tgg gtt caa aac caa gga ata ctt ccg ggt atg gtt tgg cag       1824
Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gat gtg tac ctg caa gga ccc att tgg gcc aaa att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gac ggc aac ttt cac cct tct ccg ctg atg gga ggg ttt gga atg       1920
Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac aca cct gta cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

gat cct cca acg gcc ttc aac aag gac aag ctg aac tct ttc atc acc       2016
Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr           
            660                 665                 670                   

cag tat tct act ggc caa gtc agc gtg gag atc gag tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aag gaa aac agc aag cgc tgg aac ccg gag atc cag tac act tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat tac aag tct aat aat gtt gaa ttt gct gtt aat act gaa ggt gta       2160
Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val           
705                 710                 715                 720           

tat agt gaa ccc cgc ccc att ggc acc aga tac ctg act cgt aat ctg       2208
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu           
                725                 730                 735               

taa                                                                   2211


<210>  19
<211>  736
<212>  PRT
<213>  adeno-associated virus 9

<400>  19

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  20
<211>  1962
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1962)

<400>  20
atg cgt ccc ctg cgc ccc cgc gcc gcg ctg ctg gcg ctc ctg gcc tcg         48
Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser           
1               5                   10                  15                

ctc ctg gcc gcg ccc ccg gtg gcc ccg gcc gag gcc ccg cac ctg gtg         96
Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val           
            20                  25                  30                    

cat gtg gac gcg gcc cgc gcg ctg tgg ccc ctg cgg cgc ttc tgg agg        144
His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg           
        35                  40                  45                        

agc aca ggc ttc tgc ccc ccg ctg cca cac agc cag gct gac cag tac        192
Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr           
    50                  55                  60                            

gtc ctc agc tgg gac cag cag ctc aac ctc gcc tat gtg ggc gcc gtc        240
Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val           
65                  70                  75                  80            

cct cac cgc ggc atc aag cag gtc cgg acc cac tgg ctg ctg gag ctt        288
Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu           
                85                  90                  95                

gtc acc acc agg ggg tcc act gga cgg ggc ctg agc tac aac ttc acc        336
Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr           
            100                 105                 110                   

cac ctg gac ggg tac ctg gac ctt ctc agg gag aac cag ctc ctc cca        384
His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro           
        115                 120                 125                       

ggg ttt gag ctg atg ggc agc gcc tcg ggc cac ttc act gac ttt gag        432
Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu           
    130                 135                 140                           

gac aag cag cag gtg ttt gag tgg aag gac ttg gtc tcc agc ctg gcc        480
Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala           
145                 150                 155                 160           

agg aga tac atc ggt agg tac gga ctg gcg cat gtt tcc aag tgg aac        528
Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn           
                165                 170                 175               

ttc gag acg tgg aat gag cca gac cac cac gac ttt gac aac gtc tcc        576
Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser           
            180                 185                 190                   

atg acc atg caa ggc ttc ctg aac tac tac gat gcc tgc tcg gag ggt        624
Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly           
        195                 200                 205                       

ctg cgc gcc gcc agc ccc gcc ctg cgg ctg gga ggc ccc ggc gac tcc        672
Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser           
    210                 215                 220                           

ttc cac acc cca ccg cga tcc ccg ctg agc tgg ggc ctc ctg cgc cac        720
Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His           
225                 230                 235                 240           

tgc cac gac ggt acc aac ttc ttc act ggg gag gcg ggc gtg cgg ctg        768
Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu           
                245                 250                 255               

gac tac atc tcc ctc cac agg aag ggt gcg cgc agc tcc atc tcc atc        816
Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile           
            260                 265                 270                   

ctg gag cag gag aag gtc gtc gcg cag cag atc cgg cag ctc ttc ccc        864
Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro           
        275                 280                 285                       

aag ttc gcg gac acc ccc att tac aac gac gag gcg gac ccg ctg gtg        912
Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val           
    290                 295                 300                           

ggc tgg tcc ctg cca cag ccg tgg agg gcg gac gtg acc tac gcg gcc        960
Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala           
305                 310                 315                 320           

atg gtg gtg aag gtc atc gcg cag cat cag aac ctg cta ctg gcc aac       1008
Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn           
                325                 330                 335               

acc acc tcc gcc ttc ccc tac gcg ctc ctg agc aac gac aat gcc ttc       1056
Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe           
            340                 345                 350                   

ctg agc tac cac ccg cac ccc ttc gcg cag cgc acg ctc acc gcg cgc       1104
Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg           
        355                 360                 365                       

ttc cag gtc aac aac acc cgc ccg ccg cac gtg cag ctg ttg cgc aag       1152
Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys           
    370                 375                 380                           

ccg gtg ctc acg gcc atg ggg ctg ctg gcg ctg ctg gat gag gag cag       1200
Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln           
385                 390                 395                 400           

ctc tgg gcc gaa gtg tcg cag gcc ggg acc gtc ctg gac agc aac cac       1248
Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His           
                405                 410                 415               

acg gtg ggc gtc ctg gcc agc gcc cac cgc ccc cag ggc ccg gcc gac       1296
Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp           
            420                 425                 430                   

gcc tgg cgc gcc gcg gtg ctg atc tac gcg agc gac gac acc cgc gcc       1344
Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala           
        435                 440                 445                       

cac ccc aac cgc agc gtc gcg gtg acc ctg cgg ctg cgc ggg gtg ccc       1392
His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro           
    450                 455                 460                           

ccc ggc ccg ggc ctg gtc tac gtc acg cgc tac ctg gac aac ggg ctc       1440
Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu           
465                 470                 475                 480           

tgc agc ccc gac ggc gag tgg cgg cgc ctg ggc cgg ccc gtc ttc ccc       1488
Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro           
                485                 490                 495               

acg gca gag cag ttc cgg cgc atg cgc gcg gct gag gac ccg gtg gcc       1536
Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala           
            500                 505                 510                   

gcg gcg ccc cgc ccc tta ccc gcc ggc ggc cgc ctg acc ctg cgc ccc       1584
Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro           
        515                 520                 525                       

gcg ctg cgg ctg ccg tcg ctt ttg ctg gtg cac gtg tgt gcg cgc ccc       1632
Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro           
    530                 535                 540                           

gag aag ccg ccc ggg cag gtc acg cgg ctc cgc gcc ctg ccc ctg acc       1680
Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr           
545                 550                 555                 560           

caa ggg cag ctg gtt ctg gtc tgg tcg gat gaa cac gtg ggc tcc aag       1728
Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys           
                565                 570                 575               

tgc ctg tgg aca tac gag atc cag ttc tct cag gac ggt aag gcg tac       1776
Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr           
            580                 585                 590                   

acc ccg gtc agc agg aag cca tcg acc ttc aac ctc ttt gtg ttc agc       1824
Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser           
        595                 600                 605                       

cca gac aca ggt gct gtc tct ggc tcc tac cga gtt cga gcc ctg gac       1872
Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp           
    610                 615                 620                           

tac tgg gcc cga cca ggc ccc ttc tcg gac cct gtg ccg tac ctg gag       1920
Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu           
625                 630                 635                 640           

gtc cct gtg cca aga ggg ccc cca tcc ccg ggc aat cca tga               1962
Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro                       
                645                 650                                   


<210>  21
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  22
<211>  1959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered sequence

<400>  22
atgaggcctc tcagacctag agctgctctg ctggcactgc tggcttctct gcttgctgct       60

cctcctgtgg ctcctgccga agctcctcat ctggtgcacg tggatgccgc cagagcactg      120

tggcccctga gaagattttg gcggagcacc ggcttttgcc ctccactgcc tcattctcag      180

gccgaccagt acgtgctgag ctgggaccag caactgaacc tggcctacgt gggagccgtg      240

cctcacagag gcattaagca agtgcggacc cactggctgc tggaactggt cacaacaaga      300

ggcagcacag gcagaggcct gagctacaac ttcacccacc tggacggcta cctggacctg      360

ctgagagaga atcagctgct gcctggcttc gagctgatgg gctctgcctc tggccacttc      420

accgacttcg aggacaagca gcaggttttc gagtggaagg acctggtgtc cagcctggcc      480

agacggtaca tcggcagata cggactggcc cacgtgtcca agtggaactt cgagacctgg      540

aacgagcccg accaccacga cttcgacaac gtgtcaatga ccatgcaggg ctttctgaac      600

tactacgacg cctgcagcga gggcctgaga gctgcttctc ctgctctgag acttggcggc      660

cctggcgact cttttcacac ccctccaaga agccctctgt cctggggact gctgagacac      720

tgtcacgacg gcaccaattt cttcaccggc gaggctggcg tgcggctgga ttatatcagc      780

ctgcacagaa agggcgccag aagcagcatc agcatcctgg aacaagagaa ggtggtggcc      840

cagcagatca gacagctgtt ccccaagttc gccgacacac ccatctacaa cgacgaggcc      900

gatcctctcg ttggctggtc acttcctcag ccttggagag ccgatgtgac ctatgccgcc      960

atggtggtca aagtgatcgc ccagcaccag aatctgctgc tcgccaatac caccagcgcc     1020

tttccatacg ctctgctgag caacgacaac gccttcctga gctatcaccc tcatcctttc     1080

gctcagcgga ccctgaccgc cagattccaa gtgaacaaca cccggcctcc acacgtgcag     1140

ctgctgagaa aaccagtgct gacagccatg ggcctgctcg ccctgctgga cgaagaacaa     1200

ctgtgggccg aagtgtccca ggccggaaca gtgctggata gcaatcacac agtgggcgtg     1260

ctggcctccg ctcatagacc tcaaggacca gccgatgctt ggagggctgc cgtgctgatc     1320

tacgccagcg acgatacaag ggctcacccc aacagatccg tggccgtgac actgagactg     1380

agaggcgttc caccaggacc tggcctggtg tacgtgacca gatacctgga caacggcctg     1440

tgcagccctg atggcgaatg gcgtagacta ggcagacctg tgtttcctac cgccgagcag     1500

ttcagacgga tgagagccgc tgaagatccc gtggctgctg ctccaagacc tcttccagct     1560

ggtggcagac tgactctgag gcctgcactc agactgccta gtctgctgct ggtgcacgtc     1620

tgtgccagac ctgagaagcc tcctggccaa gtgacaagac tgagggccct gccactgaca     1680

cagggacagc tggttcttgt ttggagcgac gagcacgtgg gcagcaagtg tctgtggacc     1740

tacgagatcc agttcagcca ggacggcaag gcctacacac ccgtgtctag aaagcctagc     1800

accttcaacc tgttcgtgtt cagccccgat acaggcgccg tgtctggcag ctatagagtc     1860

agagccctgg actactgggc cagaccagga ccattttctg accccgtgcc ttacctggaa     1920

gtgcccgttc ctagaggccc tccttctcct ggaaatccc                            1959


<210>  23
<211>  1959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered sequence

<400>  23
atgaggcctc tcagacctag agctgctctg ctggcactgc tggcttctct gcttgctgct       60

cctcctgtgg ctcctgccga agctcctcat ctggtgcacg tggatgccgc cagagcactg      120

tggcccctga gaagattttg gcggagcacc ggcttttgcc ctccactgcc tcattctcaa      180

gccgaccaat acgtgctgag ctgggaccag caactgaacc tggcctacgt gggagccgtg      240

cctcacagag gcattaagca agtgcggacc cactggctgc tggaactggt cacaacaaga      300

ggcagcacag gcagaggcct gagctacaac ttcacccacc tggacggcta cctggacctg      360

ctgagagaga atcagctgct gcctggcttc gagctgatgg gctctgcctc tggccacttc      420

accgacttcg aggacaagca gcaggttttc gagtggaagg acctggtgtc cagcctggcc      480

agacgctaca tcggcagata cggactggcc cacgtgtcca agtggaactt cgagacctgg      540

aacgagcccg accaccacga cttcgacaac gtgtcaatga ccatgcaggg ctttctgaac      600

tactacgacg cctgcagcga gggcctgaga gctgcttctc ctgctctgag acttggcggc      660

cctggcgact cttttcacac ccctccaaga agccctctgt cctggggact gctgagacac      720

tgtcacgacg gcaccaattt cttcaccggc gaggctggcg tgcggctgga ttatatcagc      780

ctgcacagaa agggcgccag aagcagcatc agcatcctgg aacaagagaa ggtggtggcc      840

cagcagatca gacagctgtt ccccaagttc gccgacacac ccatctacaa cgacgaggcc      900

gatcctctcg ttggctggtc acttcctcag ccttggagag ccgatgtgac ctatgccgcc      960

atggtggtca aagtgatcgc ccagcaccag aatctgctgc tcgccaatac caccagcgcc     1020

tttccatacg ctctgctgag caacgacaac gccttcctga gctatcaccc tcatcctttc     1080

gctcagcgga ccctgaccgc cagattccaa gtgaacaaca cccggcctcc acacgtgcag     1140

ctgctgagaa aaccagtgct gacagccatg ggcctgctcg ccctgctgga cgaagaacaa     1200

ctgtgggccg aagtgtccca ggccggaaca gtgctggata gcaatcacac agtgggcgtg     1260

ctggcctccg ctcatcgacc tcaaggacca gccgatgctt ggagggctgc cgtgctgatc     1320

tacgccagcg acgatacaag ggctcacccc aacagatccg tggccgtgac actgagactg     1380

agaggcgttc caccaggacc tggcctggtg tacgtgacca gatacctgga caacggcctg     1440

tgcagccctg atggcgaatg gcgtagacta ggcagacctg tgtttcctac cgccgagcag     1500

ttcagacgga tgagagccgc tgaagatccc gtggctgctg ctccaagacc tcttccagct     1560

ggtggcagac tgactctgag gcctgcactc agactgccta gtctgctgct ggtgcacgtc     1620

tgtgccagac ctgagaagcc tcctggccaa gtgacaagac tgagggccct gccactgaca     1680

cagggacagc tggttcttgt ttggagcgac gagcacgtgg gcagcaagtg tctgtggacc     1740

tacgagatcc agttcagcca ggacggcaag gcctacacac ccgtgtctag aaagcctagc     1800

accttcaacc tgttcgtgtt cagccccgat acaggcgccg tgtctggcag ctatagagtc     1860

agagccctgg actactgggc cagaccagga ccattttctg accccgtgcc ttacctggaa     1920

gtgcccgttc ctagaggccc tccttctcct ggaaatccc                            1959


<210>  24
<211>  1959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered sequence

<400>  24
atgcgaccct tgcgaccaag agccgccctg cttgcgttgt tggcttccct tttggctgca       60

ccacccgtcg ccccggcaga ggcgcctcac ctcgtgcatg tagacgcagc ccgcgccctc      120

tggccattgc ggcgattctg gaggtctacc ggtttctgcc cacccctgcc tcattcacaa      180

gccgaccaat acgttttgtc ctgggatcaa cagctcaacc ttgcgtatgt aggcgctgtt      240

ccacaccggg gaattaagca ggtccggact cactggcttc ttgagttggt tacgacgagg      300

ggttcaacag ggagagggtt gtcctacaac tttacacatc tggatggtta tttagacctg      360

ctccgagaaa accaacttct ccctggattc gagctcatgg gctctgcctc tggtcacttt      420

acggatttcg aggataaaca gcaagtcttc gagtggaagg atcttgtgag cagccttgcc      480

agaagatata taggaagata cgggttggca cacgtatcta aatggaactt tgagacttgg      540

aacgaacccg accatcacga ctttgacaac gtatctatga cgatgcaagg cttcctcaac      600

tattatgacg cgtgcagtga aggtctgagg gctgcgtctc cggcgctcag attgggaggt      660

cctggagaca gctttcatac gcctccgcga tcccctctta gctgggggtt gctcagacat      720

tgccacgacg gtacaaactt cttcaccggc gaggcaggtg ttaggctcga ctacatctcc      780

ctgcaccgaa agggcgcgcg atcttctatc agtatattgg aacaagagaa agttgtggct      840

caacaaattc gccaactttt tcccaaattc gctgataccc cgatttacaa cgacgaagcc      900

gacccattgg taggttggag tcttccccag ccttggcgag cggatgtcac ctacgcagct      960

atggtagtta aagtgattgc gcaacaccaa aatctccttc ttgccaacac gacttctgcg     1020

tttccatacg cgttgttgtc taacgacaac gcctttttgt cctatcaccc gcacccgttt     1080

gcgcagcgaa ctctgaccgc aagatttcag gttaacaata ctcggccacc acacgtacag     1140

cttttgcgca aacctgtatt gactgccatg ggattgttgg cactgttgga tgaagaacaa     1200

ctgtgggctg aagtgagcca ggcgggtaca gttctggaca gtaatcacac tgtaggcgtg     1260

ctcgccagtg ctcaccgacc acaggggccg gcagacgcct ggagagctgc tgtactcatc     1320

tacgcatcag acgataccag ggcgcatccc aatagatccg tcgccgtaac tcttcggctt     1380

cggggcgtcc cgccagggcc gggccttgtt tatgttactc gatacttaga caacggactt     1440

tgtagtcctg atggtgaatg gcgtagatta gggcggcctg tctttcctac tgcggagcag     1500

ttcagacgaa tgagggctgc tgaggaccca gttgcagctg caccccgccc gcttccggcc     1560

ggtggcagac ttacgctcag gcccgcgctt aggttgccgt ccttgttgct tgtccacgtt     1620

tgcgctcgcc cagaaaagcc gccgggacag gttacacgac ttcgggctct gcccctgacg     1680

cagggacaac tggtgcttgt ttggagtgat gaacacgtag gaagcaagtg cttgtggact     1740

tacgagatac aattcagcca agacggcaag gcttataccc ctgtttcacg caaaccttct     1800

acttttaatt tgtttgtctt ttctccggat acgggggcgg tctctgggtc atatcgcgtg     1860

agagcactcg attactgggc tagaccaggg ccatttagcg atcccgttcc ttatctggag     1920

gtgcccgtcc cgaggggtcc accaagcccc ggaaatccg                            1959


<210>  25
<211>  1959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered sequence

<400>  25
atgaggcccc tgaggcccag ggccgccctg ctggccctgc tggcctccct gctggccgct       60

cctcccgtgg ccccagccga ggctcctcac ctggtgcacg tggacgccgc cagggccctg      120

tggcccctga ggaggttctg gaggtccacc ggcttctgtc ctcctctgcc ccactcccaa      180

gccgaccaat acgtgctgtc ctgggaccag cagctgaacc tggcctatgt gggagctgtg      240

ccccacaggg gcatcaagca agtgaggacc cactggctgc tggagctggt gaccaccagg      300

ggctccaccg gcaggggcct gtcctacaac ttcacccacc tggacggcta cctggacctg      360

ctgagggaga accagctgct gcccggcttc gagctgatgg gctccgcctc cggccacttc      420

accgacttcg aggacaagca gcaggtgttc gagtggaagg acctggtgtc ctccctggcc      480

aggagataca tcggcagata cggcctggcc cacgtgtcca agtggaactt cgagacctgg      540

aacgagcccg accaccacga cttcgacaac gtgtccatga ccatgcaggg cttcctgaac      600

tactacgacg cctgctccga gggcctgagg gccgcctctc ctgccctgag gctgggagga      660

cctggcgact ccttccacac acctccaagg tctcccctgt cctggggcct gctgaggcac      720

tgccacgacg gcaccaactt cttcaccgga gaggctggag tgaggctgga ctacatctcc      780

ctgcaccgga agggcgccag gtcctccatc tccatcctgg agcaggagaa ggtggtggcc      840

cagcagatca ggcagctgtt ccccaagttc gccgacacac ctatctacaa cgacgaggcc      900

gatcctctgg tgggctggtc cctgccccag ccctggaggg ctgatgtgac ctatgctgcc      960

atggtggtga aggtgatcgc ccagcaccag aacctgctgc tggccaacac cacctccgcc     1020

ttcccctacg ccctgctgtc caacgacaac gccttcctgt cctaccatcc tcaccccttc     1080

gcccaaagga ccctgaccgc caggttccaa gtgaacaaca ccaggcctcc tcacgtgcag     1140

ctgctgagga agcccgtgct gaccgccatg ggcctgctgg ccctgctgga cgaggagcag     1200

ctgtgggccg aggtgtccca ggccggcacc gtgctggact ccaaccacac cgtgggcgtg     1260

ctggcctccg cccaccggcc ccagggcccc gccgacgcct ggagggccgc cgtgctgatc     1320

tacgcctccg acgacaccag ggcccacccc aacaggtccg tggccgtgac cctgaggctg     1380

aggggcgtgc ctcccggccc cggcctggtg tacgtgacca ggtatctgga caacggcctg     1440

tgctctcctg acggcgagtg gaggaggctg ggcaggcccg tgttccccac cgccgagcag     1500

ttcaggagga tgagggccgc cgaggacccc gtggccgccg ctcctcgacc cctgcctgct     1560

ggaggcaggc tgaccctgag gcccgccctg aggctgccct ccctgctgct ggtgcacgtg     1620

tgcgccaggc ccgagaagcc tcctggccag gtgaccaggc tgagggccct gcccctgacc     1680

cagggccagc tggtgctggt gtggtccgac gagcacgtgg gctccaagtg cctgtggacc     1740

tacgagatcc agttctccca ggacggcaag gcctacacac ctgtgtccag gaagccctcc     1800

accttcaacc tgttcgtgtt ctctcctgac accggcgccg tgtccggctc ctaccgagtg     1860

agggccctgg actactgggc caggcccggc cccttctccg accccgtgcc ctacctggag     1920

gtgcccgtgc ccaggggacc tccttctcct ggcaacccc                            1959


<210>  26
<211>  1959
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered sequence

<400>  26
atgagacctt taagaccacg tgctgctctg ctggctttac tcgcttcttt actggccgct       60

cctcccgtgg cccccgctga agctcctcac ttagtgcacg tggatgccgc cagagctctg      120

tggcctctga ggagattttg gaggtccact ggtttctgcc ctcctttacc ccatagccaa      180

gctgatcagt acgtgctgag ctgggatcag caactgaatt tagcctacgt cggcgctgtg      240

cctcacagag gcattaagca agtgaggacc cactggctgc tggaactggt caccactcgt      300

ggcagcactg gtagaggact cagctacaat ttcacacatt tagacggcta tctggattta      360

ctgagagaga atcagttatt acccggtttc gagctcatgg gaagcgcctc cggccatttc      420

accgacttcg aggacaagca gcaagttttc gaatggaaag atttagtgtc ctccctcgct      480

cgtaggtaca tcggaagata cggtttagcc cacgtcagca agtggaactt cgagacttgg      540

aatgagcccg atcaccacga ttttgacaat gtcagcatga ccatgcaagg ttttttaaac      600

tactacgatg cttgtagcga aggcctcaga gctgccagcc ccgctctgag actcggcgga      660

cccggtgact ccttccacac acctcctaga agccctttaa gctggggttt actgagacac      720

tgtcacgacg gcaccaactt ctttaccggc gaggccggcg ttcgtctcga ctatatctct      780

ttacatcgta agggcgctcg ttcctccatt tccatcctcg aacaagaaaa ggtggtggct      840

cagcagatta ggcaactctt ccccaagttc gccgacaccc ctatctataa tgacgaggct      900

gatcctctgg tcggctggtc tttaccccaa ccttggagag ctgatgtcac ctacgctgcc      960

atggtggtga aggtgatcgc ccagcaccag aatttattat tagctaacac cacatccgcc     1020

ttcccttacg ctctgctgtc caacgataac gccttcctca gctatcaccc tcaccccttt     1080

gcccagagaa ctttaaccgc tagattccaa gttaataaca ccagaccccc ccacgtccag     1140

ttattacgta agcccgttct gacagccatg ggtttactcg ctttactgga cgaagagcag     1200

ctgtgggctg aagtgagcca agctggcacc gtgctggata gcaaccacac agtgggcgtg     1260

ctcgccagcg ctcataggcc tcaaggaccc gctgatgctt ggagggctgc cgtgctgatc     1320

tacgccagcg acgacacaag ggctcacccc aataggtccg tggctgttac actgagactc     1380

agaggcgtcc cccccggtcc cggtttagtg tatgtgacca gatatttaga caacggactg     1440

tgctcccccg acggagagtg gagaagactg ggtcgtcccg tgtttcctac cgccgagcag     1500

tttaggagga tgagagctgc cgaggatccc gttgccgccg ccccacgtcc tttacccgcc     1560

ggcggaaggc tgacattaag acccgcttta agactgccct ctttactgct cgtgcatgtg     1620

tgtgccagac ccgaaaagcc tcccggacaa gttaccagac tgagagccct ccctctgacc     1680

caaggtcagc tggtgctggt gtggtccgac gaacacgtgg gcagcaagtg tttatggacc     1740

tatgagatcc agttctccca agatggcaaa gcttacaccc ccgtgtctcg taaacctagc     1800

accttcaatt tattcgtgtt tagccccgac accggagccg tgtccggcag ctatcgtgtg     1860

agagctttag actactgggc taggcccggc ccttttagcg atcccgtgcc ttatttagaa     1920

gtgcccgttc ccagaggacc ccccagcccc ggaaatcct                            1959


<210>  27
<211>  2211
<212>  DNA
<213>  adeno-associated virus rh.91


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  27
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gcg ctg aaa cct gga gcc ccg aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ttt ggt ctg gtt gag gaa gca gct aag acg gct cct gga aag aaa cgt        432
Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cag tcg ccc caa gaa cca gac tcc tcc tcg ggc att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly           
145                 150                 155                 160           

aaa tca ggc cag cag ccc gcc aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac tca gag tca gtc ccc gac cct caa cct ctc gga gaa cct cca        576
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro           
            180                 185                 190                   

gaa acc ccc gct gct gtg gga cct act aca atg gct tca ggc ggt ggc        624
Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc        672
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala           
    210                 215                 220                           

tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctt cct acc tac aac aac cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc agc gct tca acg ggg gcc agt aac gac aac cac        816
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tat ttt gat ttc aac aga ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tca cca cgt gac tgg cag cga ctc att aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg gga ttc cgg ccc aag aga ctc aac ttc aag ctc ttc aac atc cag        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gag gtc acg acg aat gat ggc gtc aca acc atc gct aat aac       1008
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt caa gtg ttc tcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tac gtc ctc ggt tct gcg cac cag ggc tgc ctc cct ccg ttc ccg gcg       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gta ttc atg att cct cag tac ggc tac cta acg ctc aac aat ggc       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agc cag gcc gta gga cgt tca tcc ttt tat tgc ctg gaa tat ttc cca       1200
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tct caa atg ctg aga acg ggc aac aac ttt acc ttc agc tac acc ttt       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gaa gat gtg cct ttc cac agc agt tac gcg cac agc cag agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

agg cta atg aat cct cta atc gac cag tac ctg tat tac cta aac aga       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg           
        435                 440                 445                       

act cag aat caa tcc gga agt gca caa aac aag gac ttg ctg ttt agc       1392
Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser           
    450                 455                 460                           

cgg ggg tct cca gct ggc atg tct gtt cag ccc aaa aac tgg cta ccc       1440
Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro           
465                 470                 475                 480           

ggg ccc tgt tac cga cag cag cgt gtt tct aaa aca aaa aca gac aac       1488
Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn           
                485                 490                 495               

aac aac agc aac ttt acc tgg act ggt gcc tcc aaa tac aat ctg aac       1536
Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn           
            500                 505                 510                   

gga cgt gaa tcc atc att aac cct ggc acc gct atg gca tcc cac aag       1584
Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys           
        515                 520                 525                       

gac gac gaa gac aaa ttt ttt ccc atg agc ggt gtt atg att ttt ggc       1632
Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly           
    530                 535                 540                           

aaa gaa aat gca gga gca tca aac act gca tta gac aat gtt atg att       1680
Lys Glu Asn Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile           
545                 550                 555                 560           

aca gat gaa gag gaa att aaa gct acc aac ccc gtg gcc acc gag aga       1728
Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg           
                565                 570                 575               

ttt gga act gtg gca gtc aat ctc caa agc agc aat aca gac cct gca       1776
Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Asn Thr Asp Pro Ala           
            580                 585                 590                   

aca gga gac gtg cat gtc atg ggg gct tta cct ggc atg gtg tgg caa       1824
Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gac gtg tac ctg cag ggt ccc att tgg gcc aag att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gat gga cac ttt cac ccg tct cct ctt atg ggc ggc ttt gga ctt       1920
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac acg cct gtt cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

aat cct ccg gca gag ttt tcg gct aca aag ttt gct tca ttc atc acc       2016
Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr           
            660                 665                 670                   

cag tac tcc aca gga caa gtg agc gtg gaa att gaa tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aaa gaa aac agt aag cgc tgg aat cct gaa gtg cag tac acc tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tac gcg aaa tct gcc aac gtt gat ttc act gtg gac aac aat gga ctt       2160
Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu           
705                 710                 715                 720           

tat act gag cct cgc ccc att ggc acc cgt tac ctt acc cgt ccc ctt       2208
Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu           
                725                 730                 735               

taa                                                                   2211


<210>  28
<211>  736
<212>  PRT
<213>  adeno-associated virus rh.91

<400>  28

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Asn Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Asn Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  29
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29
atggctgctg acggttatct tccagattgg ctcgaggaca acctttctga aggcattcgt       60

gagtggtggg ctctgaaacc tggagcccct aaacccaaag cgaaccaaca aaagcaggac      120

gacggccggg gtcttgtgct tccgggttac aaatacctcg gacccttcaa cggactcgac      180

aaaggagagc cggtcaacgc ggcggacgcg gcagccctcg aacacgacaa agcttacgac      240

cagcagctca aggccggtga caacccgtac ctccggtaca accacgccga cgccgagttt      300

caggagcgtc ttcaagaaga tacgtctttt gggggcaacc ttggcagagc agtcttccag      360

gccaaaaaga gggttcttga gccttttggt ctggttgagg aagcagctaa aacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcatcatc tggtattggc      480

aaatcgggcc agcagcctgc caaaaaaaga ctaaatttcg gtcagactgg cgactcagag      540

tcagtccccg accctcaacc tctcggagaa cctccagaaa cccccgctgc tgtgggacct      600

actacaatgg cttcaggcgg tggcgcacca atggcagaca ataacgaagg cgccgacgga      660

gtgggtaatg cctcaggaaa ttggcattgc gattccacat ggctgggcga cagagtcatc      720

accaccagca cccgaacctg ggcccttcct acctacaaca accacctcta caagcaaatc      780

tccagcgctt caacgggggc cagtaacgac aaccactact ttggctacag caccccctgg      840

gggtattttg atttcaacag attccactgc cacttctcac cacgtgactg gcagcgactc      900

attaacaaca actggggatt ccggcccaag agactcaact tcaagctctt caacatccag      960

gtcaaggagg tcacgacgaa tgatggcgtc acaaccatcg ctaataacct taccagcacg     1020

gttcaagtgt tctcggactc ggagtaccag ctgccgtacg tcctcggttc tgcgcaccag     1080

ggctgcctcc ctccgttccc ggcggacgta ttcatgattc ctcagtatgg atacctcacc     1140

ctgaacaacg gaagtcaagc ggtgggacgc tcatcctttt actgcctgga gtacttccct     1200

tcgcagatgc taaggactgg aaataacttc accttcagct ataccttcga ggatgtacct     1260

tttcacagca gctacgctca cagccagagt ttggatcgct tgatgaatcc tcttattgat     1320

cagtatctgt actacctgaa cagaacgcaa aatcaatctg gaagtgcaca aaacaaggac     1380

ctgcttttta gccgggggtc tcctgctggc atgtctgttc agcccaaaaa ttggctacct     1440

gggccctgct accggcaaca gagagtttca aagactaaaa cagacaacaa caacagtaac     1500

tttacctgga caggtgccag caaatataat ctcaatggcc gcgaatcgat cattaatcca     1560

ggaaccgcta tggccagtca caaggacgat gaagacaaat ttttccctat gagcggcgtt     1620

atgatatttg gcaaagaaaa tgcaggagca agtaacactg cattagataa tgtaatgatt     1680

acggatgaag aagagattaa agctaccaat cctgtggcaa cagagagatt tggaactgtg     1740

gcagtcaact tgcagagctc aaatacagac cccgcaactg gagacgtcca tgtcatgggg     1800

gccttacctg gcatggtgtg gcaagatcgt gacgtgtacc ttcaaggacc tatctgggca     1860

aagattcctc acacggatgg acactttcat ccttctcctc tgatgggagg ctttggactg     1920

aaacatccgc ctcctcaaat cctcatcaaa aatactccgg taccggcaaa tcctccggca     1980

gagttcagcg ctacaaagtt tgcttcattt atcactcagt actccactgg acaggtcagc     2040

gtggaaattg agtgggagct acagaaagaa aacagcaaac gttggaatcc agaggtgcag     2100

tacacttcca actacgcgaa gtctgccaat gtggacttta ctgtagacaa caatggtctt     2160

tatactgaac ctcgccctat tggaacccgg tatctcacac gacccttgta a              2211


