                         SEQUENCE LISTING

<110>  Neoleukin Therapeutics, Inc.
       Walkey, Carl
       Drachman, Jonathan
       Ulge, Umut
       Silva Manzano, Daniel Adriano
 
<120>  Methods of Administration of IL-2 Receptor Agonists

<130>  057318-501001WO

<140>  Herewith
<141>  Herewith

<150>  US 62/926,302
<151>  2019-10-25

<150>  US 62/953,372
<151>  2019-12-24

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  1

Glu His Ala Leu Tyr Asp Ala Leu 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  2

Tyr Ala Phe Asn Phe Glu Leu Ile 
1               5               


<210>  3
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  3

Ile Thr Ile Leu Gln Ser Trp Ile Phe 
1               5                   


<210>  4
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  4

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile 
            20          


<210>  5
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  5

Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile Ala 
1               5                   10                  15      


Arg Leu Phe Glu Ser Gly 
            20          


<210>  6
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  6

Glu Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln 
1               5                   10                  15      


Ser Trp Ile Phe Ser 
            20      


<210>  7
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  7

Lys Asp Glu Ala Glu Lys Ala Lys Arg Met Lys Glu Trp Met Lys Arg 
1               5                   10                  15      


Ile Lys Thr 
            


<210>  8
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  8

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  9
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  9

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  10
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  10

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Cys Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  11
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  11

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Cys Leu Phe Glu Ser Gly Xaa Xaa Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  12
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  12

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Cys Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  13
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  13

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Cys Ser Gly Xaa Xaa Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  14
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  14

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Cys Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  15
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  15

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Cys Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  16
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Cys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  17
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  17

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Cys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  18
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  18

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Cys Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  19
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  19

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Lys Cys Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  20
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  20

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Cys Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  21
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  21

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Lys Asp Glu Ala Cys Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  22
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  22

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Cys Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  23
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  23

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Cys Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  24
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  24

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Cys Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  25
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  25

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Cys Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  26
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  26

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Cys Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  27
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  27

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Cys Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  28
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  28

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Cys Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  29
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<400>  29

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Cys Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  30
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  30

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Cys Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  31
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  31

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Cys Gln Glu Glu Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  32
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  32

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Val Lys Thr Asn Ser Pro Pro Ala Glu Glu 
            20                  25                  30          


Lys Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Asp Gln Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Thr Ala Ser Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Cys Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


<210>  33
<211>  100
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (23)..(33)
<223>  Amino acids 23-33 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(57)
<223>  Amino acids 56-57 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (77)..(79)
<223>  Amino acids 77-79 may be present or absent

<400>  33

Pro Lys Lys Lys Ile Gln Leu His Ala Glu His Ala Leu Tyr Asp Ala 
1               5                   10                  15      


Leu Met Ile Leu Asn Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Glu Asp Tyr Ala Phe Asn Phe Glu Leu Ile Leu Glu Glu Ile 
        35                  40                  45              


Ala Arg Leu Phe Glu Ser Gly Xaa Xaa Lys Asp Glu Ala Glu Lys Ala 
    50                  55                  60                  


Lys Arg Met Lys Glu Trp Met Lys Arg Ile Lys Thr Xaa Xaa Xaa Glu 
65                  70                  75                  80  


Asp Glu Gln Glu Cys Met Ala Asn Ala Ile Ile Thr Ile Leu Gln Ser 
                85                  90                  95      


Trp Ile Phe Ser 
            100 


