                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> COMPOSITIONS AND METHODS FOR EDITING OF THE CDKL5 GENE

<130> 060933-9510

<140> PCT/US2020/056726
<141> 2020-10-21

<150> 62/925,731
<151> 2019-10-24

<150> 62/924,141
<151> 2019-10-21

<160> 43    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
agagcatcgg accgaagcgg                                                   20


<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
gggggagaac atactcgggg                                                   20


<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
cccaggttgc tagggcttgg                                                   20


<210> 4
<211> 701
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CMV promoter sequence

<400> 4
atacgcgttg acattgatta ttgactagtt attaatagta atcaattacg gggtcattag       60

ttcatagccc atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct      120

gaccgcccaa cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc      180

caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg      240

cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat      300

ggcccgcctg gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca      360

tctacgtatt agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc      420

gtggatagcg gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga      480

gtttgttttg gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat      540

tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcgtttag      600

tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat agaagacacc      660

gggaccgatc cagcctccgg actctagagg atcgaaccct t                          701


<210> 5
<211> 249
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      U6 promoter sequence

<400> 5
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattagaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacacc                                                              249


<210> 6
<211> 11
<212> PRT
<213> Herpes simplex virus

<400> 6
Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
1               5                   10      


<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
atcgcctgaa acttgtccgg                                                   20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
cgaaagggtg tgaaagaggg                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
tggggaaggt aaagcggcga                                                   20


<210> 10
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
agagcatcgg accgaagc                                                     18


<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
gcttgagcaa tttcggaccc                                                   20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
tgtgtctctt gctggtaccg                                                   20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
tgagcctgtg ccagaggata                                                   20


<210> 14
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
tcaactttga ttgccaagtg ca                                                22


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
gagcagttct ggaaccaacc                                                   20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
ttgaggccga agagagatgt                                                   20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
ccttgtggaa tttgggtcat                                                   20


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
tcaaatgcag gcacttagaa t                                                 21


<210> 19
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
caaggaaaaa gagaagcaag ga                                                22


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
attttaatgg ctggctttgg                                                   20


<210> 21
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ttttagttta ggttgttagg gtttg                                             25


<210> 22
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
taaaaaaaca cctcaaattt taccc                                             25


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
tcatcctcct tggaaacccg                                                   20


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
gtcatcgccc aaccagtaca                                                   20


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
agcagcagca atggacttcg                                                   20


<210> 26
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
agaaatacag gatggaggat ggt                                               23


<210> 27
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
aagcgcttcc tcctcattgg                                                   20


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
aaagcacctc aggttttgcc                                                   20


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
agctgttgat tggctgcttt                                                   20


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
ttcaaattcc gcccactaaa                                                   20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
cacctcccag cttcactctc                                                   20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
ctgcgggttc atctagttcc                                                   20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
acaaccagca ttcgatccat                                                   20


<210> 34
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
gctgtcggaa ttgggtactg ttt                                               23


<210> 35
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
gctgtcggaa ttgggtactg ttg                                               23


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
aactcttact tggcgctccc                                                   20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
ctgtccatcg ctaagctccc                                                   20


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
aatcccatca ccatcttcca                                                   20


<210> 39
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
ctccatggtg gtgaagacg                                                    19


<210> 40
<211> 11
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      CDKL5 gDNA sequence

<400> 40
atctcmaaca g                                                            11


<210> 41
<211> 13
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown:
      CA5B gDNA sequence

<400> 41
acaagcraaa ccc                                                          13


<210> 42
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
atctcaaaca g                                                            11


<210> 43
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
acaagcraaa ccc                                                          13

