                         SEQUENCE LISTING

<110>  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
 
<120>  RECOMBINANT NEURAMINIDASE AND USES THEREOF

<130>  6923-305-228

<140>
<141>

<150>  US 62/924,511
<151>  2019-10-22

<160>  66    

<170>  PatentIn version 3.5

<210>  1
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetramerization domain from SEPPALLATA-like MADS domain 
       transcription factor from Arabidopsis thaliana (SMDTF)

<400>  1

Val Glu Leu Ser Ser Gln Gln Glu Tyr Leu Lys Leu Lys Glu Arg Tyr 
1               5                   10                  15      


Asp Ala Leu Gln Arg Thr Gln Arg Asn Leu Leu Gly Glu Asp Leu Gly 
            20                  25                  30          


Pro Leu Ser Thr Lys Glu Leu Glu Ser Leu Glu Arg Gln Leu Asp Ser 
        35                  40                  45              


Ser Leu Lys Gln Ile Arg Ala Leu Arg Thr Gln Phe Met Leu Asp Gln 
    50                  55                  60                  


Ser Lys Glu Arg Met Leu Thr Glu Thr Asn Lys Thr Leu Arg Leu Arg 
65                  70                  75                  80  


Leu Ala Asp Gly Tyr 
                85  


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sendai virus phosphoprotein tetramerization domain (SPP)

<400>  2

Glu Asn Thr Ser Ser Met Lys Glu Met Ala Thr Leu Leu Thr Ser Leu 
1               5                   10                  15      


Gly Val Ile Gln Ser Ala Gln Glu Phe Glu Ser Ser Arg Asp Ala Ser 
            20                  25                  30          


Tyr Val Phe Ala Arg Arg Ala Leu Lys Ser Ala Asn Tyr Ala Glu Met 
        35                  40                  45              


Thr Phe Asn Val Cys Gly Leu Ile Leu Ser Ala Glu Lys Ser Ser Ala 
    50                  55                  60                  


Arg Lys Val Asp Glu Asn Lys Gln Leu Leu Lys Ile Gln Glu Ser Val 
65                  70                  75                  80  


Glu Ser Phe Arg Asp Ile Tyr Lys Arg Phe Ser Glu Tyr Gln Lys Glu 
                85                  90                  95      


Gln Asn Ser Leu Leu Met Ser Asn Leu Ser Thr Leu His Ile Ile Thr 
            100                 105                 110         


Asp 
    


<210>  3
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PiLZ structure from Xhantomonas campestris

<400>  3

Leu Leu Val Gln Arg Met Asp Ala Lys Leu Asp Leu Ile Leu Ala Leu 
1               5                   10                  15      


Ile Gly Arg Leu Val Arg Gln Ser 
            20                  


<210>  4
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Measles virus phosphoprotein tetramerization domain (MPP)

<400>  4

Gly Asp His Tyr Asp Asp Glu Leu Phe Ser Asp Val Gln Asp Ile Lys 
1               5                   10                  15      


Thr Ala Leu Ala Lys Ile His Glu Asp Asn Gln Lys Ile Ile Ser Lys 
            20                  25                  30          


Leu Glu Ser Leu Leu Leu Leu Lys Gly Glu Val Glu Ser Ile Lys Lys 
        35                  40                  45              


Gln Ile Asn Arg Gln Asn Ile Ser Ile Ser Thr Leu Glu Gly His Leu 
    50                  55                  60                  


Ser Ser Ile Met Ile Ala Ile Pro Gly Leu 
65                  70                  


<210>  5
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dictyocaulus viviparus ACE tetramerization domain

<400>  5

Ala Val Ala Asp Val Gly Asp Pro Phe Leu Leu Trp Lys Gln Gln Met 
1               5                   10                  15      


Asp Lys Trp Gln Asn Glu Tyr Ile Thr Asp Trp Gln Tyr His Phe Glu 
            20                  25                  30          


Gln Tyr Lys Lys Tyr Gln Thr Tyr Arg His Leu Asp Ser Asp Ser Cys 
        35                  40                  45              


Ser Gly Ser 
    50      


<210>  6
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR8 N1 Wild-type

<400>  6

Met Asn Pro Asn Gln Lys Ile Thr Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Asn Ile Ile Thr Tyr Lys Asn Ser Thr Trp Val Lys Asp 
    50                  55                  60                  


Thr Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Arg 
65                  70                  75                  80  


Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys 
                85                  90                  95      


Gly Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu 
            100                 105                 110         


Glu Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys 
        115                 120                 125             


His Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met 
    130                 135                 140                 


Ser Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu 
145                 150                 155                 160 


Ser Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu 
                165                 170                 175     


Thr Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys 
            180                 185                 190         


Tyr Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Lys Ile 
        195                 200                 205             


Leu Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe 
    210                 215                 220                 


Thr Ile Met Thr Asp Gly Pro Ser Asp Gly Leu Ala Ser Tyr Lys Ile 
225                 230                 235                 240 


Phe Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala 
                245                 250                 255     


Pro Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys 
            260                 265                 270         


Val Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp 
        275                 280                 285             


Val Ser Phe Asp Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser 
    290                 295                 300                 


Gly Val Phe Gly Asp Asn Pro Arg Pro Glu Asp Gly Thr Gly Ser Cys 
305                 310                 315                 320 


Gly Pro Val Tyr Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr 
                325                 330                 335     


Arg Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser His Ser Ser 
            340                 345                 350         


Arg His Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr 
        355                 360                 365             


Asp Ser Lys Phe Ser Val Arg Gln Asp Val Val Ala Met Thr Asp Trp 
    370                 375                 380                 


Ser Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu 
385                 390                 395                 400 


Asp Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro 
                405                 410                 415     


Lys Glu Lys Thr Ile Trp Thr Ser Ala Ser Ser Ile Ser Phe Cys Gly 
            420                 425                 430         


Val Asn Ser Asp Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu Leu 
        435                 440                 445             


Pro Phe Ser Ile Asp Lys 
    450                 


<210>  7
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR8 N1 I48C

<400>  7

Met Asn Pro Asn Gln Lys Ile Thr Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Cys 
        35                  40                  45              


Cys Asn Gln Asn Ile Ile Thr Tyr Lys Asn Ser Thr Trp Val Lys Asp 
    50                  55                  60                  


Thr Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Arg 
65                  70                  75                  80  


Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys 
                85                  90                  95      


Gly Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu 
            100                 105                 110         


Glu Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys 
        115                 120                 125             


His Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met 
    130                 135                 140                 


Ser Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu 
145                 150                 155                 160 


Ser Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu 
                165                 170                 175     


Thr Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys 
            180                 185                 190         


Tyr Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Lys Ile 
        195                 200                 205             


Leu Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe 
    210                 215                 220                 


Thr Ile Met Thr Asp Gly Pro Ser Asp Gly Leu Ala Ser Tyr Lys Ile 
225                 230                 235                 240 


Phe Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala 
                245                 250                 255     


Pro Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys 
            260                 265                 270         


Val Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp 
        275                 280                 285             


Val Ser Phe Asp Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser 
    290                 295                 300                 


Gly Val Phe Gly Asp Asn Pro Arg Pro Glu Asp Gly Thr Gly Ser Cys 
305                 310                 315                 320 


Gly Pro Val Tyr Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr 
                325                 330                 335     


Arg Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser His Ser Ser 
            340                 345                 350         


Arg His Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr 
        355                 360                 365             


Asp Ser Lys Phe Ser Val Arg Gln Asp Val Val Ala Met Thr Asp Trp 
    370                 375                 380                 


Ser Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu 
385                 390                 395                 400 


Asp Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro 
                405                 410                 415     


Lys Glu Lys Thr Ile Trp Thr Ser Ala Ser Ser Ile Ser Phe Cys Gly 
            420                 425                 430         


Val Asn Ser Asp Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu Leu 
        435                 440                 445             


Pro Phe Ser Ile Asp Lys 
    450                 


<210>  8
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR8 N1 N50C

<400>  8

Met Asn Pro Asn Gln Lys Ile Thr Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile 
        35                  40                  45              


Cys Cys Gln Asn Ile Ile Thr Tyr Lys Asn Ser Thr Trp Val Lys Asp 
    50                  55                  60                  


Thr Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Arg 
65                  70                  75                  80  


Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys 
                85                  90                  95      


Gly Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu 
            100                 105                 110         


Glu Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys 
        115                 120                 125             


His Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met 
    130                 135                 140                 


Ser Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu 
145                 150                 155                 160 


Ser Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu 
                165                 170                 175     


Thr Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys 
            180                 185                 190         


Tyr Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Lys Ile 
        195                 200                 205             


Leu Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe 
    210                 215                 220                 


Thr Ile Met Thr Asp Gly Pro Ser Asp Gly Leu Ala Ser Tyr Lys Ile 
225                 230                 235                 240 


Phe Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala 
                245                 250                 255     


Pro Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys 
            260                 265                 270         


Val Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp 
        275                 280                 285             


Val Ser Phe Asp Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser 
    290                 295                 300                 


Gly Val Phe Gly Asp Asn Pro Arg Pro Glu Asp Gly Thr Gly Ser Cys 
305                 310                 315                 320 


Gly Pro Val Tyr Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr 
                325                 330                 335     


Arg Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser His Ser Ser 
            340                 345                 350         


Arg His Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr 
        355                 360                 365             


Asp Ser Lys Phe Ser Val Arg Gln Asp Val Val Ala Met Thr Asp Trp 
    370                 375                 380                 


Ser Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu 
385                 390                 395                 400 


Asp Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro 
                405                 410                 415     


Lys Glu Lys Thr Ile Trp Thr Ser Ala Ser Ser Ile Ser Phe Cys Gly 
            420                 425                 430         


Val Asn Ser Asp Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu Leu 
        435                 440                 445             


Pro Phe Ser Ile Asp Lys 
    450                 


<210>  9
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR8 N1 61insertC

<400>  9

Met Asn Pro Asn Gln Lys Ile Thr Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Asn Ile Ile Thr Tyr Lys Asn Ser Thr Trp Cys Val Lys 
    50                  55                  60                  


Asp Thr Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile 
65                  70                  75                  80  


Arg Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser 
                85                  90                  95      


Lys Gly Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His 
            100                 105                 110         


Leu Glu Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp 
        115                 120                 125             


Lys His Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu 
    130                 135                 140                 


Met Ser Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe 
145                 150                 155                 160 


Glu Ser Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp 
                165                 170                 175     


Leu Thr Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu 
            180                 185                 190         


Lys Tyr Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Lys 
        195                 200                 205             


Ile Leu Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys 
    210                 215                 220                 


Phe Thr Ile Met Thr Asp Gly Pro Ser Asp Gly Leu Ala Ser Tyr Lys 
225                 230                 235                 240 


Ile Phe Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn 
                245                 250                 255     


Ala Pro Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly 
            260                 265                 270         


Lys Val Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro 
        275                 280                 285             


Trp Val Ser Phe Asp Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys 
    290                 295                 300                 


Ser Gly Val Phe Gly Asp Asn Pro Arg Pro Glu Asp Gly Thr Gly Ser 
305                 310                 315                 320 


Cys Gly Pro Val Tyr Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser 
                325                 330                 335     


Tyr Arg Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser His Ser 
            340                 345                 350         


Ser Arg His Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu 
        355                 360                 365             


Thr Asp Ser Lys Phe Ser Val Arg Gln Asp Val Val Ala Met Thr Asp 
    370                 375                 380                 


Trp Ser Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly 
385                 390                 395                 400 


Leu Asp Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg 
                405                 410                 415     


Pro Lys Glu Lys Thr Ile Trp Thr Ser Ala Ser Ser Ile Ser Phe Cys 
            420                 425                 430         


Gly Val Asn Ser Asp Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu 
        435                 440                 445             


Leu Pro Phe Ser Ile Asp Lys 
    450                 455 


<210>  10
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR8 N1 I48C_N50C

<400>  10

Met Asn Pro Asn Gln Lys Ile Thr Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Cys 
        35                  40                  45              


Cys Cys Gln Asn Ile Ile Thr Tyr Lys Asn Ser Thr Trp Val Lys Asp 
    50                  55                  60                  


Thr Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Arg 
65                  70                  75                  80  


Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys 
                85                  90                  95      


Gly Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu 
            100                 105                 110         


Glu Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys 
        115                 120                 125             


His Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met 
    130                 135                 140                 


Ser Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu 
145                 150                 155                 160 


Ser Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu 
                165                 170                 175     


Thr Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys 
            180                 185                 190         


Tyr Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Lys Ile 
        195                 200                 205             


Leu Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe 
    210                 215                 220                 


Thr Ile Met Thr Asp Gly Pro Ser Asp Gly Leu Ala Ser Tyr Lys Ile 
225                 230                 235                 240 


Phe Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala 
                245                 250                 255     


Pro Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys 
            260                 265                 270         


Val Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp 
        275                 280                 285             


Val Ser Phe Asp Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser 
    290                 295                 300                 


Gly Val Phe Gly Asp Asn Pro Arg Pro Glu Asp Gly Thr Gly Ser Cys 
305                 310                 315                 320 


Gly Pro Val Tyr Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr 
                325                 330                 335     


Arg Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser His Ser Ser 
            340                 345                 350         


Arg His Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr 
        355                 360                 365             


Asp Ser Lys Phe Ser Val Arg Gln Asp Val Val Ala Met Thr Asp Trp 
    370                 375                 380                 


Ser Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu 
385                 390                 395                 400 


Asp Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro 
                405                 410                 415     


Lys Glu Lys Thr Ile Trp Thr Ser Ala Ser Ser Ile Ser Phe Cys Gly 
            420                 425                 430         


Val Asn Ser Asp Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu Leu 
        435                 440                 445             


Pro Phe Ser Ile Asp Lys 
    450                 


<210>  11
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR8 N1 I48C_61insertC

<400>  11

Met Asn Pro Asn Gln Lys Ile Thr Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Cys 
        35                  40                  45              


Cys Asn Gln Asn Ile Ile Thr Tyr Lys Asn Ser Thr Trp Cys Val Lys 
    50                  55                  60                  


Asp Thr Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile 
65                  70                  75                  80  


Arg Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser 
                85                  90                  95      


Lys Gly Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His 
            100                 105                 110         


Leu Glu Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp 
        115                 120                 125             


Lys His Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu 
    130                 135                 140                 


Met Ser Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe 
145                 150                 155                 160 


Glu Ser Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp 
                165                 170                 175     


Leu Thr Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu 
            180                 185                 190         


Lys Tyr Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Lys 
        195                 200                 205             


Ile Leu Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys 
    210                 215                 220                 


Phe Thr Ile Met Thr Asp Gly Pro Ser Asp Gly Leu Ala Ser Tyr Lys 
225                 230                 235                 240 


Ile Phe Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn 
                245                 250                 255     


Ala Pro Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly 
            260                 265                 270         


Lys Val Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro 
        275                 280                 285             


Trp Val Ser Phe Asp Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys 
    290                 295                 300                 


Ser Gly Val Phe Gly Asp Asn Pro Arg Pro Glu Asp Gly Thr Gly Ser 
305                 310                 315                 320 


Cys Gly Pro Val Tyr Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser 
                325                 330                 335     


Tyr Arg Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser His Ser 
            340                 345                 350         


Ser Arg His Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu 
        355                 360                 365             


Thr Asp Ser Lys Phe Ser Val Arg Gln Asp Val Val Ala Met Thr Asp 
    370                 375                 380                 


Trp Ser Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly 
385                 390                 395                 400 


Leu Asp Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg 
                405                 410                 415     


Pro Lys Glu Lys Thr Ile Trp Thr Ser Ala Ser Ser Ile Ser Phe Cys 
            420                 425                 430         


Gly Val Asn Ser Asp Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu 
        435                 440                 445             


Leu Pro Phe Ser Ile Asp Lys 
    450                 455 


<210>  12
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HK14 N2 Wild-type

<400>  12

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Pro Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gly Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asn Thr Val Arg Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Val Val Ser Trp Ser Lys Asp Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Ile Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Thr Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Asn Glu 
        355                 360                 365             


Thr Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Lys Ser Lys Leu Gln Thr Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asp Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Leu 
    450                 455                 460                 


Asn Leu Met Pro Ile 
465                 


<210>  13
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HK14 N2 L52C

<400>  13

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Cys Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Pro Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gly Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asn Thr Val Arg Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Val Val Ser Trp Ser Lys Asp Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Ile Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Thr Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Asn Glu 
        355                 360                 365             


Thr Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Lys Ser Lys Leu Gln Thr Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asp Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Leu 
    450                 455                 460                 


Asn Leu Met Pro Ile 
465                 


<210>  14
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HK14 N2 L52C_E54C

<400>  14

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Cys Cys Cys Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Pro Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gly Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asn Thr Val Arg Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Val Val Ser Trp Ser Lys Asp Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Ile Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Thr Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Asn Glu 
        355                 360                 365             


Thr Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Lys Ser Lys Leu Gln Thr Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asp Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Leu 
    450                 455                 460                 


Asn Leu Met Pro Ile 
465                 


<210>  15
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1.2

<400>  15

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ser 
        35                  40                  45              


Leu Val Pro Arg Gly Ser Pro Ser Arg Ile Glu Thr Cys Asn Gln Ser 
    50                  55                  60                  


Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val Asn 
65                  70                  75                  80  


Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val Val Ser Val Lys 
                85                  90                  95      


Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr 
            100                 105                 110         


Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
        115                 120                 125             


Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe 
    130                 135                 140                 


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
145                 150                 155                 160 


Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly 
                165                 170                 175     


Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
            180                 185                 190         


Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser 
        195                 200                 205             


Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
    210                 215                 220                 


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
225                 230                 235                 240 


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp 
                245                 250                 255     


Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys 
            260                 265                 270         


Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr 
        275                 280                 285             


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys 
    290                 295                 300                 


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
305                 310                 315                 320 


Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
                325                 330                 335     


Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser 
            340                 345                 350         


Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
        355                 360                 365             


Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu 
    370                 375                 380                 


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser 
385                 390                 395                 400 


Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly 
                405                 410                 415     


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
            420                 425                 430         


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile 
        435                 440                 445             


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
    450                 455                 460                 


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
465                 470                 475                 480 


Lys 
    


<210>  16
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1.3 (C49A - monomer)

<400>  16

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ser 
        35                  40                  45              


Leu Val Pro Arg Gly Ser Pro Ser Arg Ile Glu Thr Ala Asn Gln Ser 
    50                  55                  60                  


Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val Asn 
65                  70                  75                  80  


Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val Val Ser Val Lys 
                85                  90                  95      


Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr 
            100                 105                 110         


Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
        115                 120                 125             


Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe 
    130                 135                 140                 


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
145                 150                 155                 160 


Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly 
                165                 170                 175     


Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
            180                 185                 190         


Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser 
        195                 200                 205             


Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
    210                 215                 220                 


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
225                 230                 235                 240 


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp 
                245                 250                 255     


Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys 
            260                 265                 270         


Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr 
        275                 280                 285             


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys 
    290                 295                 300                 


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
305                 310                 315                 320 


Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
                325                 330                 335     


Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser 
            340                 345                 350         


Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
        355                 360                 365             


Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu 
    370                 375                 380                 


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser 
385                 390                 395                 400 


Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly 
                405                 410                 415     


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
            420                 425                 430         


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile 
        435                 440                 445             


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
    450                 455                 460                 


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
465                 470                 475                 480 


Lys 
    


<210>  17
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1.4 (T48C)

<400>  17

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ser 
        35                  40                  45              


Leu Val Pro Arg Gly Ser Pro Ser Arg Ile Glu Cys Cys Asn Gln Ser 
    50                  55                  60                  


Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val Asn 
65                  70                  75                  80  


Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val Val Ser Val Lys 
                85                  90                  95      


Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr 
            100                 105                 110         


Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
        115                 120                 125             


Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe 
    130                 135                 140                 


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
145                 150                 155                 160 


Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly 
                165                 170                 175     


Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
            180                 185                 190         


Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser 
        195                 200                 205             


Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
    210                 215                 220                 


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
225                 230                 235                 240 


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp 
                245                 250                 255     


Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys 
            260                 265                 270         


Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr 
        275                 280                 285             


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys 
    290                 295                 300                 


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
305                 310                 315                 320 


Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
                325                 330                 335     


Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser 
            340                 345                 350         


Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
        355                 360                 365             


Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu 
    370                 375                 380                 


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser 
385                 390                 395                 400 


Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly 
                405                 410                 415     


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
            420                 425                 430         


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile 
        435                 440                 445             


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
    450                 455                 460                 


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
465                 470                 475                 480 


Lys 
    


<210>  18
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1.5 (N50C)

<400>  18

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ser 
        35                  40                  45              


Leu Val Pro Arg Gly Ser Pro Ser Arg Ile Glu Thr Cys Cys Gln Ser 
    50                  55                  60                  


Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val Asn 
65                  70                  75                  80  


Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val Val Ser Val Lys 
                85                  90                  95      


Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr 
            100                 105                 110         


Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
        115                 120                 125             


Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe 
    130                 135                 140                 


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
145                 150                 155                 160 


Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly 
                165                 170                 175     


Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
            180                 185                 190         


Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser 
        195                 200                 205             


Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
    210                 215                 220                 


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
225                 230                 235                 240 


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp 
                245                 250                 255     


Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys 
            260                 265                 270         


Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr 
        275                 280                 285             


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys 
    290                 295                 300                 


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
305                 310                 315                 320 


Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
                325                 330                 335     


Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser 
            340                 345                 350         


Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
        355                 360                 365             


Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu 
    370                 375                 380                 


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser 
385                 390                 395                 400 


Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly 
                405                 410                 415     


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
            420                 425                 430         


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile 
        435                 440                 445             


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
    450                 455                 460                 


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
465                 470                 475                 480 


Lys 
    


<210>  19
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1.6 (T48C+N50C)

<400>  19

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ser 
        35                  40                  45              


Leu Val Pro Arg Gly Ser Pro Ser Arg Ile Glu Cys Cys Cys Gln Ser 
    50                  55                  60                  


Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val Asn 
65                  70                  75                  80  


Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val Val Ser Val Lys 
                85                  90                  95      


Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr 
            100                 105                 110         


Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
        115                 120                 125             


Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe 
    130                 135                 140                 


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
145                 150                 155                 160 


Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly 
                165                 170                 175     


Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
            180                 185                 190         


Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser 
        195                 200                 205             


Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
    210                 215                 220                 


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
225                 230                 235                 240 


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp 
                245                 250                 255     


Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys 
            260                 265                 270         


Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr 
        275                 280                 285             


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys 
    290                 295                 300                 


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
305                 310                 315                 320 


Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
                325                 330                 335     


Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser 
            340                 345                 350         


Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
        355                 360                 365             


Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu 
    370                 375                 380                 


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser 
385                 390                 395                 400 


Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly 
                405                 410                 415     


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
            420                 425                 430         


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile 
        435                 440                 445             


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
    450                 455                 460                 


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
465                 470                 475                 480 


Lys 
    


<210>  20
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1.7 (A76C)

<400>  20

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ser 
        35                  40                  45              


Leu Val Pro Arg Gly Ser Pro Ser Arg Ile Glu Thr Cys Asn Gln Ser 
    50                  55                  60                  


Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val Asn 
65                  70                  75                  80  


Ile Ser Asn Thr Asn Phe Ala Cys Gly Gln Ser Val Val Ser Val Lys 
                85                  90                  95      


Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr 
            100                 105                 110         


Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
        115                 120                 125             


Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe 
    130                 135                 140                 


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
145                 150                 155                 160 


Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly 
                165                 170                 175     


Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
            180                 185                 190         


Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser 
        195                 200                 205             


Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
    210                 215                 220                 


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
225                 230                 235                 240 


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp 
                245                 250                 255     


Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys 
            260                 265                 270         


Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr 
        275                 280                 285             


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys 
    290                 295                 300                 


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
305                 310                 315                 320 


Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
                325                 330                 335     


Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser 
            340                 345                 350         


Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
        355                 360                 365             


Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu 
    370                 375                 380                 


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser 
385                 390                 395                 400 


Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly 
                405                 410                 415     


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
            420                 425                 430         


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile 
        435                 440                 445             


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
    450                 455                 460                 


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
465                 470                 475                 480 


Lys 
    


<210>  21
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1.8 (Q78C)

<400>  21

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ser 
        35                  40                  45              


Leu Val Pro Arg Gly Ser Pro Ser Arg Ile Glu Thr Cys Asn Gln Ser 
    50                  55                  60                  


Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val Asn 
65                  70                  75                  80  


Ile Ser Asn Thr Asn Phe Ala Ala Gly Cys Ser Val Val Ser Val Lys 
                85                  90                  95      


Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr 
            100                 105                 110         


Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
        115                 120                 125             


Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe 
    130                 135                 140                 


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
145                 150                 155                 160 


Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly 
                165                 170                 175     


Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
            180                 185                 190         


Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser 
        195                 200                 205             


Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
    210                 215                 220                 


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
225                 230                 235                 240 


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp 
                245                 250                 255     


Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys 
            260                 265                 270         


Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr 
        275                 280                 285             


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys 
    290                 295                 300                 


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
305                 310                 315                 320 


Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
                325                 330                 335     


Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser 
            340                 345                 350         


Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
        355                 360                 365             


Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu 
    370                 375                 380                 


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser 
385                 390                 395                 400 


Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly 
                405                 410                 415     


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
            420                 425                 430         


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile 
        435                 440                 445             


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
    450                 455                 460                 


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
465                 470                 475                 480 


Lys 
    


<210>  22
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1.9 (V81C)

<400>  22

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ser 
        35                  40                  45              


Leu Val Pro Arg Gly Ser Pro Ser Arg Ile Glu Thr Cys Asn Gln Ser 
    50                  55                  60                  


Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln Thr Tyr Val Asn 
65                  70                  75                  80  


Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val Cys Ser Val Lys 
                85                  90                  95      


Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr 
            100                 105                 110         


Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
        115                 120                 125             


Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe 
    130                 135                 140                 


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
145                 150                 155                 160 


Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly 
                165                 170                 175     


Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
            180                 185                 190         


Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser 
        195                 200                 205             


Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
    210                 215                 220                 


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
225                 230                 235                 240 


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp 
                245                 250                 255     


Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys 
            260                 265                 270         


Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr 
        275                 280                 285             


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys 
    290                 295                 300                 


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
305                 310                 315                 320 


Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
                325                 330                 335     


Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser 
            340                 345                 350         


Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
        355                 360                 365             


Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu 
    370                 375                 380                 


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser 
385                 390                 395                 400 


Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly 
                405                 410                 415     


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
            420                 425                 430         


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile 
        435                 440                 445             


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
    450                 455                 460                 


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
465                 470                 475                 480 


Lys 
    


<210>  23
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1.11 (W61C)

<400>  23

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ser 
        35                  40                  45              


Leu Val Pro Arg Gly Ser Pro Ser Arg Ile Glu Thr Cys Asn Gln Ser 
    50                  55                  60                  


Val Ile Thr Tyr Glu Asn Asn Thr Cys Val Asn Gln Thr Tyr Val Asn 
65                  70                  75                  80  


Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val Val Ser Val Lys 
                85                  90                  95      


Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr 
            100                 105                 110         


Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val 
        115                 120                 125             


Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe 
    130                 135                 140                 


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr 
145                 150                 155                 160 


Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly 
                165                 170                 175     


Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser 
            180                 185                 190         


Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser 
        195                 200                 205             


Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile 
    210                 215                 220                 


Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu 
225                 230                 235                 240 


Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp 
                245                 250                 255     


Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys 
            260                 265                 270         


Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr 
        275                 280                 285             


Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys 
    290                 295                 300                 


Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln 
305                 310                 315                 320 


Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp 
                325                 330                 335     


Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser 
            340                 345                 350         


Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly 
        355                 360                 365             


Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu 
    370                 375                 380                 


Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser 
385                 390                 395                 400 


Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly 
                405                 410                 415     


Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro 
            420                 425                 430         


Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile 
        435                 440                 445             


Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr 
    450                 455                 460                 


Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp 
465                 470                 475                 480 


Lys 
    


<210>  24
<211>  530
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SMDTF-N1

<400>  24

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Val 
        35                  40                  45              


Glu Leu Ser Ser Gln Gln Glu Tyr Leu Lys Leu Lys Glu Arg Tyr Asp 
    50                  55                  60                  


Ala Leu Gln Arg Thr Gln Arg Asn Leu Leu Gly Glu Asp Leu Gly Pro 
65                  70                  75                  80  


Leu Ser Thr Lys Glu Leu Glu Ser Leu Glu Arg Gln Leu Asp Ser Ser 
                85                  90                  95      


Leu Lys Gln Ile Arg Ala Leu Arg Thr Gln Phe Met Leu Asp Gln Ser 
            100                 105                 110         


Lys Glu Arg Met Leu Thr Glu Thr Asn Lys Thr Leu Arg Leu Arg Leu 
        115                 120                 125             


Ala Asp Gly Tyr Ser Leu Val Pro Arg Gly Ser Pro Ser Arg Ser Val 
    130                 135                 140                 


Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile 
145                 150                 155                 160 


Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe 
                165                 170                 175     


Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr 
            180                 185                 190         


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly 
        195                 200                 205             


Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile 
    210                 215                 220                 


Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp 
225                 230                 235                 240 


Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile 
                245                 250                 255     


Ser Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile 
            260                 265                 270         


Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln 
        275                 280                 285             


Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr 
    290                 295                 300                 


Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu 
305                 310                 315                 320 


Lys Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His 
                325                 330                 335     


Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val 
            340                 345                 350         


Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn 
        355                 360                 365             


Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly 
    370                 375                 380                 


Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser 
385                 390                 395                 400 


Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn 
                405                 410                 415     


Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe 
            420                 425                 430         


Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe 
        435                 440                 445             


Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser 
    450                 455                 460                 


Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg 
465                 470                 475                 480 


Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr 
                485                 490                 495     


Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp 
            500                 505                 510         


Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile 
        515                 520                 525             


Asp Lys 
    530 


<210>  25
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPP-N1

<400>  25

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Glu 
        35                  40                  45              


Asn Thr Ser Ser Met Lys Glu Met Ala Thr Leu Leu Thr Ser Leu Gly 
    50                  55                  60                  


Val Ile Gln Ser Ala Gln Glu Phe Glu Ser Ser Arg Asp Ala Ser Tyr 
65                  70                  75                  80  


Val Phe Ala Arg Arg Ala Leu Lys Ser Ala Asn Tyr Ala Glu Met Thr 
                85                  90                  95      


Phe Asn Val Cys Gly Leu Ile Leu Ser Ala Glu Lys Ser Ser Ala Arg 
            100                 105                 110         


Lys Val Asp Glu Asn Lys Gln Leu Leu Lys Ile Gln Glu Ser Val Glu 
        115                 120                 125             


Ser Phe Arg Asp Ile Tyr Lys Arg Phe Ser Glu Tyr Gln Lys Glu Gln 
    130                 135                 140                 


Asn Ser Leu Leu Met Ser Asn Leu Ser Thr Leu His Ile Ile Thr Asp 
145                 150                 155                 160 


Ser Leu Val Pro Arg Gly Ser Pro Ser Arg Ser Val Lys Leu Ala Gly 
                165                 170                 175     


Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr Ser Lys Asp 
            180                 185                 190         


Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val Ile Arg Glu 
        195                 200                 205             


Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe Phe Leu Thr 
    210                 215                 220                 


Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr Ile Lys Asp 
225                 230                 235                 240 


Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly Glu Val Pro 
                245                 250                 255     


Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser Ala Ser Ala 
            260                 265                 270         


Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser Gly Pro Asp 
        275                 280                 285             


Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile Thr Asp Thr 
    290                 295                 300                 


Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu Ser Glu Cys 
305                 310                 315                 320 


Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp Gly Pro Ser 
                325                 330                 335     


Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys Gly Lys Ile 
            340                 345                 350         


Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr Glu Glu Cys 
        355                 360                 365             


Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys Arg Asp Asn 
    370                 375                 380                 


Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln Asn Leu Glu 
385                 390                 395                 400 


Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp Asn Pro Arg 
                405                 410                 415     


Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser Asn Gly Ala 
            420                 425                 430         


Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly Val Trp Ile 
        435                 440                 445             


Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu Met Ile Trp 
    450                 455                 460                 


Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser Ile Lys Gln 
465                 470                 475                 480 


Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly Ser Phe Val 
                485                 490                 495     


Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro Cys Phe Trp 
            500                 505                 510         


Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile Trp Thr Ser 
        515                 520                 525             


Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr Val Gly Trp 
    530                 535                 540                 


Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp Lys 
545                 550                 555             


<210>  26
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PiLZ-N1

<400>  26

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Leu 
        35                  40                  45              


Leu Val Gln Arg Met Asp Ala Lys Leu Asp Leu Ile Leu Ala Leu Ile 
    50                  55                  60                  


Gly Arg Leu Val Arg Gln Ser Ser Leu Val Pro Arg Gly Ser Pro Ser 
65                  70                  75                  80  


Arg Ser Val Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Ile Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Arg Ile Glu Lys Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile 
        275                 280                 285             


Thr Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys 
            340                 345                 350         


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg 
        355                 360                 365             


Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp 
    370                 375                 380                 


Asn Lys Phe Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Thr Ile Asp Lys 
465                 


<210>  27
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MPP-N1

<400>  27

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Gly 
        35                  40                  45              


Asp His Tyr Asp Asp Glu Leu Phe Ser Asp Val Gln Asp Ile Lys Thr 
    50                  55                  60                  


Ala Leu Ala Lys Ile His Glu Asp Asn Gln Lys Ile Ile Ser Lys Leu 
65                  70                  75                  80  


Glu Ser Leu Leu Leu Leu Lys Gly Glu Val Glu Ser Ile Lys Lys Gln 
                85                  90                  95      


Ile Asn Arg Gln Asn Ile Ser Ile Ser Thr Leu Glu Gly His Leu Ser 
            100                 105                 110         


Ser Ile Met Ile Ala Ile Pro Gly Leu Ser Leu Val Pro Arg Gly Ser 
        115                 120                 125             


Pro Ser Arg Ser Val Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val 
    130                 135                 140                 


Ser Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser 
145                 150                 155                 160 


Lys Gly Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro 
                165                 170                 175     


Leu Glu Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp 
            180                 185                 190         


Lys His Ser Asn Gly Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu 
        195                 200                 205             


Met Ser Cys Pro Ile Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe 
    210                 215                 220                 


Glu Ser Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp 
225                 230                 235                 240 


Leu Thr Ile Gly Ile Ser Gly Pro Asp Ser Gly Ala Val Ala Val Leu 
                245                 250                 255     


Lys Tyr Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn 
            260                 265                 270         


Ile Leu Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys 
        275                 280                 285             


Phe Thr Ile Met Thr Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys 
    290                 295                 300                 


Ile Phe Arg Ile Glu Lys Gly Lys Ile Ile Lys Ser Val Glu Met Lys 
305                 310                 315                 320 


Ala Pro Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser 
                325                 330                 335     


Glu Ile Thr Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro 
            340                 345                 350         


Trp Val Ser Phe Asn Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys 
        355                 360                 365             


Ser Gly Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser 
    370                 375                 380                 


Cys Gly Pro Val Ser Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser 
385                 390                 395                 400 


Phe Lys Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser 
                405                 410                 415     


Ser Arg Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly 
            420                 425                 430         


Thr Asp Asn Lys Phe Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu 
        435                 440                 445             


Trp Ser Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly 
    450                 455                 460                 


Leu Asp Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg 
465                 470                 475                 480 


Pro Glu Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys 
                485                 490                 495     


Gly Val Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu 
            500                 505                 510         


Leu Pro Phe Thr Ile Asp Lys 
        515                 


<210>  28
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACE-N1

<400>  28

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Ala 
        35                  40                  45              


Val Ala Asp Val Gly Asp Pro Phe Leu Leu Trp Lys Gln Gln Met Asp 
    50                  55                  60                  


Lys Trp Gln Asn Glu Tyr Ile Thr Asp Trp Gln Tyr His Phe Glu Gln 
65                  70                  75                  80  


Tyr Lys Lys Tyr Gln Thr Tyr Arg His Leu Asp Ser Asp Ser Cys Ser 
                85                  90                  95      


Gly Ser Ser Leu Val Pro Arg Gly Ser Pro Ser Arg Ser Val Lys Leu 
            100                 105                 110         


Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr Ser 
        115                 120                 125             


Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val Ile 
    130                 135                 140                 


Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe Phe 
145                 150                 155                 160 


Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr Ile 
                165                 170                 175     


Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly Glu 
            180                 185                 190         


Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser Ala 
        195                 200                 205             


Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser Gly 
    210                 215                 220                 


Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile Thr 
225                 230                 235                 240 


Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu Ser 
                245                 250                 255     


Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp Gly 
            260                 265                 270         


Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys Gly 
        275                 280                 285             


Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr Glu 
    290                 295                 300                 


Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys Arg 
305                 310                 315                 320 


Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln Asn 
                325                 330                 335     


Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp Asn 
            340                 345                 350         


Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser Asn 
        355                 360                 365             


Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly Val 
    370                 375                 380                 


Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu Met 
385                 390                 395                 400 


Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser Ile 
                405                 410                 415     


Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly Ser 
            420                 425                 430         


Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro Cys 
        435                 440                 445             


Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile Trp 
    450                 455                 460                 


Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr Val 
465                 470                 475                 480 


Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp Lys 
                485                 490                 495     


<210>  29
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1 PR8

<400>  29

Met Asn Pro Asn Gln Lys Ile Thr Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Asn Ile Ile Thr Tyr Lys Asn Ser Thr Trp Val Lys Asp 
    50                  55                  60                  


Thr Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Arg 
65                  70                  75                  80  


Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys 
                85                  90                  95      


Gly Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu 
            100                 105                 110         


Glu Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys 
        115                 120                 125             


His Ser Asn Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met 
    130                 135                 140                 


Ser Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu 
145                 150                 155                 160 


Ser Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu 
                165                 170                 175     


Thr Ile Gly Ile Ser Gly Pro Asp Asn Gly Ala Val Ala Val Leu Lys 
            180                 185                 190         


Tyr Asn Gly Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Lys Ile 
        195                 200                 205             


Leu Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe 
    210                 215                 220                 


Thr Ile Met Thr Asp Gly Pro Ser Asp Gly Leu Ala Ser Tyr Lys Ile 
225                 230                 235                 240 


Phe Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala 
                245                 250                 255     


Pro Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys 
            260                 265                 270         


Val Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp 
        275                 280                 285             


Val Ser Phe Asp Gln Asn Leu Asp Tyr Gln Ile Gly Tyr Ile Cys Ser 
    290                 295                 300                 


Gly Val Phe Gly Asp Asn Pro Arg Pro Glu Asp Gly Thr Gly Ser Cys 
305                 310                 315                 320 


Gly Pro Val Tyr Val Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr 
                325                 330                 335     


Arg Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser His Ser Ser 
            340                 345                 350         


Arg His Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr 
        355                 360                 365             


Asp Ser Lys Phe Ser Val Arg Gln Asp Val Val Ala Met Thr Asp Trp 
    370                 375                 380                 


Ser Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu 
385                 390                 395                 400 


Asp Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro 
                405                 410                 415     


Lys Glu Lys Thr Ile Trp Thr Ser Ala Ser Ser Ile Ser Phe Cys Gly 
            420                 425                 430         


Val Asn Ser Asp Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu Leu 
        435                 440                 445             


Pro Phe Ser Ile Asp Lys 
    450                 


<210>  30
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1_Mich15

<400>  30

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Thr 
1               5                   10                  15      


Ile Gly Met Ala Asn Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Val Ser His Ser Ile Gln Ile Gly Asn Gln Ser Gln Ile Glu Thr 
        35                  40                  45              


Cys Asn Gln Ser Val Ile Thr Tyr Glu Asn Asn Thr Trp Val Asn Gln 
    50                  55                  60                  


Thr Tyr Val Asn Ile Ser Asn Thr Asn Phe Ala Ala Gly Gln Ser Val 
65                  70                  75                  80  


Val Ser Val Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly 
                85                  90                  95      


Trp Ala Ile Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly 
            100                 105                 110         


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu 
        115                 120                 125             


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser 
145                 150                 155                 160 


Cys Pro Ile Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
                165                 170                 175     


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr 
            180                 185                 190         


Ile Gly Ile Ser Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr 
        195                 200                 205             


Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr 
225                 230                 235                 240 


Ile Met Thr Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe 
                245                 250                 255     


Arg Ile Glu Lys Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro 
            260                 265                 270         


Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile 
        275                 280                 285             


Thr Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
    290                 295                 300                 


Ser Phe Asn Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly 
305                 310                 315                 320 


Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly 
                325                 330                 335     


Pro Val Ser Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys 
            340                 345                 350         


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg 
        355                 360                 365             


Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp 
    370                 375                 380                 


Asn Lys Phe Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
                405                 410                 415     


Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu 
            420                 425                 430         


Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val 
        435                 440                 445             


Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
    450                 455                 460                 


Phe Thr Ile Asp Lys 
465                 


<210>  31
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1_WSN

<400>  31

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Cys Met Val 
1               5                   10                  15      


Val Gly Ile Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Asn Gln Asn His Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Gly Ser Ile Thr Tyr Lys Val Val Ala Gly Gln Asp Ser 
    50                  55                  60                  


Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Arg Gly 
65                  70                  75                  80  


Trp Ala Ile His Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Lys Gly 
                85                  90                  95      


Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser His Leu Glu 
            100                 105                 110         


Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His 
        115                 120                 125             


Ser Arg Gly Thr Phe Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser 
    130                 135                 140                 


Cys Pro Val Gly Glu Ala Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser 
145                 150                 155                 160 


Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly Met Gly Trp Leu Thr 
                165                 170                 175     


Ile Gly Ile Ser Gly Pro Asp Asp Gly Ala Val Ala Val Leu Lys Tyr 
            180                 185                 190         


Asn Arg Ile Ile Thr Glu Thr Ile Lys Ser Trp Arg Lys Asn Ile Leu 
        195                 200                 205             


Arg Thr Gln Glu Ser Glu Cys Thr Cys Val Asn Gly Ser Cys Phe Thr 
    210                 215                 220                 


Ile Met Thr Asp Gly Pro Ser Asp Gly Leu Ala Ser Tyr Lys Ile Phe 
225                 230                 235                 240 


Lys Ile Glu Lys Gly Lys Val Thr Lys Ser Ile Glu Leu Asn Ala Pro 
                245                 250                 255     


Asn Ser His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Thr Gly Lys Val 
            260                 265                 270         


Met Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val 
        275                 280                 285             


Ser Phe Asp Gln Asn Leu Asp Tyr Lys Ile Gly Tyr Ile Cys Ser Gly 
    290                 295                 300                 


Val Phe Gly Asp Asn Pro Arg Pro Lys Asp Gly Thr Gly Ser Cys Gly 
305                 310                 315                 320 


Pro Val Ser Ala Asp Gly Ala Asn Gly Val Lys Gly Phe Ser Tyr Lys 
                325                 330                 335     


Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Asp Ser Ser Arg 
            340                 345                 350         


His Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Glu Thr Asp 
        355                 360                 365             


Ser Arg Phe Ser Met Arg Gln Asp Val Val Ala Ile Thr Asn Arg Ser 
    370                 375                 380                 


Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp 
385                 390                 395                 400 


Cys Met Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Leu Pro Glu 
                405                 410                 415     


Glu Asp Ala Ile Trp Thr Ser Gly Ser Ile Ile Ser Phe Cys Gly Val 
            420                 425                 430         


Asn Ser Asp Thr Val Asp Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro 
        435                 440                 445             


Phe Thr Ile Asp Lys 
    450             


<210>  32
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N2_HK14


<220>
<221>  MISC_FEATURE
<222>  (148)..(148)
<223>  X is unknown in public database

<400>  32

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Pro Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gly Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Val His 
    130                 135                 140                 


Ser Asn Asn Xaa Val Arg Asp Arg Thr Pro Tyr Arg Thr Leu Leu Met 
145                 150                 155                 160 


Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala Trp Leu His Val 
            180                 185                 190         


Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Phe Ile Tyr Asn 
        195                 200                 205             


Gly Arg Leu Val Asp Ser Val Val Ser Trp Ser Lys Asp Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Ile Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Lys Ala Asp Thr Lys Ile Leu Phe 
                245                 250                 255     


Ile Glu Glu Gly Lys Ile Val His Thr Ser Thr Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Gly Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Ile Val Asp 
    290                 295                 300                 


Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Lys Asn Asp Ser Ser Ser Ser Ser His 
                325                 330                 335     


Cys Leu Asp Pro Asn Asn Glu Glu Gly Gly His Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg Thr Ile Asn Glu 
        355                 360                 365             


Thr Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Ile Glu Gly Trp Ser 
    370                 375                 380                 


Asn Pro Lys Ser Lys Leu Gln Thr Asn Arg Gln Val Ile Val Asp Arg 
385                 390                 395                 400 


Gly Asp Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Ser 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Lys Glu 
            420                 425                 430         


Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asp Leu 
    450                 455                 460                 


Asn Leu Met Pro Ile 
465                 


<210>  33
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N2_ck


<220>
<221>  MISC_FEATURE
<222>  (356)..(356)
<223>  X is unknown in public database

<400>  33

Met Asn Pro Asn Gln Lys Ile Ile Ala Leu Gly Ser Ala Ser Leu Thr 
1               5                   10                  15      


Ile Ala Ile Val Cys Leu Leu Ile Gln Ile Ala Ile Leu Ala Thr Thr 
            20                  25                  30          


Met Thr Leu His Phe Thr Gln Ser Glu Tyr Thr Asn Ser Ser Thr Asn 
        35                  40                  45              


Lys Val Val Ser Cys Glu Ser Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val His Leu Asn Gly Thr Ile Ile Glu Arg Glu Ser Cys Pro Lys 
65                  70                  75                  80  


Ser Ala Glu Tyr Lys Asn Trp Ser Lys Pro Gln Cys Gln Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys Ser Leu Asn Lys 
        115                 120                 125             


Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Leu Asn Asn Arg His 
    130                 135                 140                 


Ser Asn Gly Thr Thr His Asp Arg Ser Pro Tyr Arg Thr Leu Leu Met 
145                 150                 155                 160 


Ser Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys Gln Val Cys Ile 
                165                 170                 175     


Ala Trp Ser Ser Ser Ser Cys His Asp Gly Arg Ala Trp Leu His Val 
            180                 185                 190         


Cys Val Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser Val Ile Tyr Asp 
        195                 200                 205             


Gly Met Leu Thr Asp Ser Ile Val Ser Trp Ser Lys Asn Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr Cys Thr Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Gly Met Ala Asp Thr Arg Ile Leu Phe 
                245                 250                 255     


Ile Arg Glu Gly Lys Ile Val His Ile Ser Pro Leu Ser Gly Ser Ala 
            260                 265                 270         


Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr Pro Glu Val Arg 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Val Leu Tyr 
    290                 295                 300                 


Ile Asn Met Ala Asp Tyr Asn Ile Asp Ser Asn Tyr Val Cys Ser Gly 
305                 310                 315                 320 


Leu Val Gly Asp Thr Pro Arg Ser Asp Asp Ser Ser Ser Ser Ser Asn 
                325                 330                 335     


Cys Arg Asp Pro Asn Asn Glu Arg Gly Gly Pro Gly Val Lys Gly Trp 
            340                 345                 350         


Ala Phe Asp Xaa Gly Asp Asp Val Trp Met Gly Arg Thr Ile Lys Lys 
        355                 360                 365             


Asp Ser Arg Ala Gly Tyr Glu Thr Phe Arg Val Val Asp Gly Trp Thr 
    370                 375                 380                 


Val Ala Asn Ser Lys Ser Gln Thr Asn Arg Gln Val Ile Val Glu Ser 
385                 390                 395                 400 


Asp Asn Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val Glu Gly Lys Thr 
                405                 410                 415     


Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Pro Gln 
            420                 425                 430         


Glu Thr Arg Val Trp Trp Thr Ser Asn Ser Ile Ile Val Phe Cys Gly 
        435                 440                 445             


Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp Gly Ala Asn Ile 
    450                 455                 460                 


Asn Phe Met Ser Ile 
465                 


<210>  34
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N3_sw

<400>  34

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Val Val Asn Thr Thr 
1               5                   10                  15      


Leu Ser Thr Ile Ala Leu Leu Ile Gly Val Gly Asn Leu Ile Phe Asn 
            20                  25                  30          


Thr Val Ile His Glu Lys Ile Gly Asp His Gln Ile Val Thr Tyr Pro 
        35                  40                  45              


Thr Ile Thr Thr Pro Ala Val Pro Asn Cys Ser Asp Thr Ile Ile Thr 
    50                  55                  60                  


Tyr Asn Asn Thr Val Ile Asn Asn Ile Thr Thr Thr Ile Ile Thr Glu 
65                  70                  75                  80  


Glu Glu Arg Pro Phe Lys Ser Pro Leu Pro Leu Cys Pro Phe Arg Gly 
                85                  90                  95      


Phe Phe Pro Phe His Lys Asp Asn Ala Ile Arg Leu Gly Glu Asn Lys 
            100                 105                 110         


Asp Val Ile Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Asn Asp Asn 
        115                 120                 125             


Cys Trp Ser Phe Ala Leu Thr Gln Gly Ala Leu Leu Gly Thr Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Ile Lys Asp Arg Thr Pro Tyr Arg Ser Leu Ile Arg 
145                 150                 155                 160 


Phe Pro Ile Gly Thr Ala Pro Val Leu Gly Asn Tyr Lys Glu Ile Cys 
                165                 170                 175     


Ile Ala Trp Ser Ser Ser Ser Cys Phe Asp Gly Lys Glu Trp Met His 
            180                 185                 190         


Val Cys Met Thr Gly Asn Asp Asn Asp Ala Ser Ala Gln Ile Ile Tyr 
        195                 200                 205             


Gly Gly Arg Met Thr Asp Ser Ile Lys Ser Trp Arg Lys Asp Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Gln Cys Ile Asp Gly Thr Cys Val Val 
225                 230                 235                 240 


Ala Val Thr Asp Gly Pro Ala Ala Asn Ser Ala Asp Tyr Arg Val Tyr 
                245                 250                 255     


Trp Ile Arg Glu Gly Lys Ile Ile Lys Tyr Glu Asn Val Pro Lys Thr 
            260                 265                 270         


Lys Ile Gln His Leu Glu Glu Cys Ser Cys Tyr Val Asp Ile Asp Val 
        275                 280                 285             


Tyr Cys Ile Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Trp Met 
    290                 295                 300                 


Arg Ile Asn Asn Glu Thr Ile Leu Glu Thr Gly Tyr Val Cys Ser Lys 
305                 310                 315                 320 


Phe His Ser Asp Thr Pro Arg Pro Ala Asp Pro Ser Thr Met Ser Cys 
                325                 330                 335     


Asp Ser Pro Ser Asn Val Asn Gly Gly Pro Gly Val Lys Gly Phe Gly 
            340                 345                 350         


Phe Lys Ala Gly Asp Asp Val Trp Leu Gly Arg Thr Val Ser Thr Ser 
        355                 360                 365             


Gly Arg Ser Gly Phe Glu Ile Ile Lys Val Thr Glu Gly Trp Ile Asn 
    370                 375                 380                 


Ser Pro Asn His Val Lys Ser Ile Thr Gln Thr Leu Val Ser Asn Asn 
385                 390                 395                 400 


Asp Trp Ser Gly Tyr Ser Gly Ser Phe Ile Val Lys Ala Lys Asp Cys 
                405                 410                 415     


Phe Gln Pro Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Pro Asn Lys 
            420                 425                 430         


Asn Asp Asp Val Ser Trp Thr Ser Asn Ser Ile Val Thr Phe Cys Gly 
        435                 440                 445             


Leu Asp Asn Glu Pro Gly Ser Gly Asn Trp Pro Asp Gly Ser Asn Ile 
    450                 455                 460                 


Gly Phe Met Pro Lys 
465                 


<210>  35
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N3_bwt

<400>  35

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Val Val Asn Thr Thr 
1               5                   10                  15      


Leu Ser Thr Ile Ala Leu Leu Ile Gly Val Gly Asn Leu Val Phe Asn 
            20                  25                  30          


Thr Val Ile His Glu Lys Ile Gly Asp His Gln Thr Val Thr His Pro 
        35                  40                  45              


Thr Ile Thr Thr Pro Ala Ile Pro Asn Cys Ser Asp Thr Ile Ile Thr 
    50                  55                  60                  


Tyr Asn Asn Thr Val Ile Asn Asn Ile Thr Thr Thr Ile Ile Thr Glu 
65                  70                  75                  80  


Ala Glu Arg Pro Phe Lys Ser Pro Leu Pro Leu Cys Pro Phe Arg Gly 
                85                  90                  95      


Phe Phe Pro Phe His Lys Asp Asn Ala Ile Arg Leu Gly Glu Asn Lys 
            100                 105                 110         


Gly Val Ile Val Thr Arg Glu Pro Tyr Ile Ser Cys Asp Asn Asp Asn 
        115                 120                 125             


Cys Trp Ser Phe Ala Leu Ala Gln Gly Ala Leu Leu Gly Thr Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Ile Lys Asp Arg Thr Pro Tyr Arg Ser Leu Ile Arg 
145                 150                 155                 160 


Phe Pro Ile Gly Thr Ala Pro Val Leu Gly Asn Tyr Lys Glu Ile Cys 
                165                 170                 175     


Ile Ala Trp Ser Ser Ser Ser Cys Phe Asp Gly Lys Glu Trp Met His 
            180                 185                 190         


Val Cys Met Thr Gly Asn Asp Asn Asp Ala Ser Ala Gln Ile Ile Tyr 
        195                 200                 205             


Ala Gly Arg Met Thr Asp Ser Ile Lys Ser Trp Arg Lys Asp Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Gln Cys Ile Asp Gly Thr Cys Val Val 
225                 230                 235                 240 


Ala Val Thr Asp Gly Pro Ala Ala Asn Ser Ala Asp His Arg Val Tyr 
                245                 250                 255     


Trp Ile Arg Glu Gly Lys Ile Ile Lys Tyr Glu Asp Val Pro Lys Thr 
            260                 265                 270         


Lys Ile Gln His Leu Glu Glu Cys Ser Cys Tyr Val Asp Ile Asp Val 
        275                 280                 285             


Tyr Cys Ile Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Trp Met 
    290                 295                 300                 


Arg Ile Asn Asn Glu Thr Ile Leu Glu Thr Gly Tyr Val Cys Ser Lys 
305                 310                 315                 320 


Phe His Ser Asp Thr Pro Arg Pro Ala Asp Pro Ser Thr Met Ser Cys 
                325                 330                 335     


Asp Ser Pro Ser Asn Val Asn Gly Gly Pro Gly Val Lys Gly Phe Gly 
            340                 345                 350         


Phe Lys Ala Gly Asn Asp Val Trp Leu Gly Arg Thr Val Ser Thr Ser 
        355                 360                 365             


Gly Arg Ser Gly Phe Glu Ile Ile Lys Val Thr Glu Gly Trp Ile Asn 
    370                 375                 380                 


Ser Pro Asn His Ala Lys Ser Ile Thr Gln Thr Leu Val Ser Asn Asn 
385                 390                 395                 400 


Asp Trp Ser Gly Tyr Ser Gly Ser Phe Ile Val Lys Thr Lys Asp Cys 
                405                 410                 415     


Phe Gln Pro Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Pro Asn Lys 
            420                 425                 430         


Asn Asp Asp Val Ser Trp Thr Ser Asn Ser Ile Val Thr Phe Cys Gly 
        435                 440                 445             


Leu Asp Asn Glu Pro Gly Ser Gly Asn Trp Pro Asp Gly Ser Asn Ile 
    450                 455                 460                 


Gly Phe Met Pro Lys 
465                 


<210>  36
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N3_duck

<400>  36

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Val Val Asn Thr Thr 
1               5                   10                  15      


Leu Ser Thr Ile Ala Leu Leu Ile Gly Ile Gly Asn Leu Ile Phe Asn 
            20                  25                  30          


Thr Val Ile His Glu Lys Ile Gly Val His Gln Thr Val Val Tyr Pro 
        35                  40                  45              


Thr Ile Thr Pro Pro Val Ile Pro Asn Cys Ser Asp Thr Thr Ile Thr 
    50                  55                  60                  


Tyr Asn Asn Thr Val Val Asn Asn Ile Thr Ala Thr Ile Ile Asn Lys 
65                  70                  75                  80  


Ala Glu Lys Gln Phe Lys Pro Ser Leu Pro Leu Cys Pro Phe Arg Gly 
                85                  90                  95      


Phe Phe Pro Phe His Lys Asp Asn Ala Ile Arg Leu Gly Glu Asn Lys 
            100                 105                 110         


Asp Val Ile Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Asn Asp Asp 
        115                 120                 125             


Cys Trp Ser Phe Ala Leu Ala Gln Gly Ala Leu Leu Gly Thr Lys His 
    130                 135                 140                 


Ser Asn Gly Thr Ile Lys Asp Arg Thr Pro Tyr Arg Ser Leu Ile Arg 
145                 150                 155                 160 


Phe Pro Ile Gly Thr Ala Pro Val Leu Gly Asn Tyr Lys Glu Ile Cys 
                165                 170                 175     


Val Ala Trp Ser Ser Ser Ser Cys Phe Asp Gly Lys Glu Trp Met His 
            180                 185                 190         


Val Cys Met Thr Gly Asn Asp Asn Asp Ala Ser Gly Gln Ile Ile Tyr 
        195                 200                 205             


Ala Gly Lys Met Thr Asp Ser Ile Lys Ser Trp Arg Arg Asp Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Gln Cys Ile Asp Gly Thr Cys Ile Val 
225                 230                 235                 240 


Ala Val Thr Asp Gly Pro Ala Ala Ser Ser Ala Asp His Arg Ile Tyr 
                245                 250                 255     


Trp Ile Arg Lys Gly Lys Ile Ile Lys Tyr Glu Asp Ile Pro Lys Thr 
            260                 265                 270         


Lys Ile Gln His Leu Glu Glu Cys Ser Cys Tyr Val Asp Thr Asp Val 
        275                 280                 285             


Tyr Cys Ile Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg Pro Trp Met 
    290                 295                 300                 


Arg Ile Asn Asn Glu Thr Ile Leu Glu Thr Gly Tyr Val Cys Ser Lys 
305                 310                 315                 320 


Phe His Ser Asp Thr Pro Arg Pro Ala Asp Pro Ser Thr Val Ser Cys 
                325                 330                 335     


Asp Ser Pro Ser Asn Ile Asn Gly Gly Pro Gly Val Lys Gly Phe Gly 
            340                 345                 350         


Phe Arg Ala Gly Asn Asp Val Trp Leu Gly Arg Thr Val Ser Thr Thr 
        355                 360                 365             


Gly Arg Ser Gly Phe Glu Val Ile Lys Val Thr Glu Gly Trp Ile Asn 
    370                 375                 380                 


Ser Leu Asn His Ala Lys Ser Ile Thr Gln Thr Leu Val Ser Asn Asn 
385                 390                 395                 400 


Asp Trp Ser Gly Tyr Ser Gly Ser Phe Ile Val Glu Asn Asn Gly Cys 
                405                 410                 415     


Phe Gln Pro Cys Phe Tyr Ile Glu Leu Ile Arg Gly Arg Pro Asn Arg 
            420                 425                 430         


Asn Asp Asp Val Ser Trp Thr Ser Asn Ser Ile Val Thr Phe Cys Gly 
        435                 440                 445             


Leu Asp Asn Glu Pro Gly Ser Gly Asn Trp Pro Asp Gly Ser Asn Ile 
    450                 455                 460                 


Gly Phe Met Pro Lys 
465                 


<210>  37
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N4_duck

<400>  37

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Ile Val 
1               5                   10                  15      


Leu Thr Thr Ile Gly Leu Leu Leu Gln Ile Thr Ser Leu Cys Ser Ile 
            20                  25                  30          


Trp Phe Ser His Tyr Asn Gln Val Thr Gln Thr Ser Glu Gln Ser Cys 
        35                  40                  45              


Ser Asn Asn Thr Thr Asn Tyr Tyr Asn Glu Thr Phe Val Asn Val Thr 
    50                  55                  60                  


Asn Val Gln Asn Asn Tyr Thr Thr Ile Thr Glu Pro Ser Ser Pro Gln 
65                  70                  75                  80  


Val Ile His Tyr Ser Ser Gly Arg Asp Leu Cys Pro Val Lys Gly Trp 
                85                  90                  95      


Ala Pro Leu Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Arg Gly Glu 
            100                 105                 110         


Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Ile Asn Glu Cys 
        115                 120                 125             


Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser 
    130                 135                 140                 


Asn Gly Thr Val Lys Asp Arg Ser Pro Phe Arg Thr Leu Met Ser Cys 
145                 150                 155                 160 


Pro Ile Gly Val Ala Pro Ser Pro Ser Asn Ser Arg Phe Glu Ser Val 
                165                 170                 175     


Ala Trp Ser Ala Thr Ala Cys Ser Asp Gly Pro Gly Trp Leu Thr Leu 
            180                 185                 190         


Gly Ile Thr Gly Pro Asp Ser Thr Ala Val Ala Val Ile Lys Tyr Asn 
        195                 200                 205             


Gly Ile Ile Thr Asp Thr Leu Lys Ser Trp Lys Gly Asn Ile Met Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Gln Asp Glu Phe Cys Tyr Thr Leu 
225                 230                 235                 240 


Ile Thr Asp Gly Pro Ser Asp Ala Gln Ala Phe Tyr Lys Ile Leu Lys 
                245                 250                 255     


Ile Arg Lys Gly Lys Ile Met Ser Val Lys Asp Val Asp Ala Thr Gly 
            260                 265                 270         


Phe His Phe Glu Glu Cys Ser Cys Tyr Pro Ser Gly Glu Asn Val Glu 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Arg Gly Ser Asn Arg Pro Trp Ile Arg 
    290                 295                 300                 


Phe Asn Ser Asp Leu Asp Tyr Gln Ile Gly Tyr Val Cys Ser Gly Val 
305                 310                 315                 320 


Phe Gly Asp Asn Pro Arg Pro Val Asp Gly Thr Gly Ser Cys Ser Gly 
                325                 330                 335     


Pro Ile Asn Asn Gly Lys Gly Arg Tyr Gly Val Lys Gly Phe Ser Phe 
            340                 345                 350         


Arg Tyr Gly Asp Gly Val Trp Ile Gly Arg Thr Lys Ser Leu Glu Ser 
        355                 360                 365             


Arg Ser Gly Phe Glu Met Val Trp Asp Ala Asn Gly Trp Val Ser Thr 
    370                 375                 380                 


Asp Lys Asp Ser Asn Gly Val Gln Asp Ile Ile Asp Asn Asp Asn Trp 
385                 390                 395                 400 


Ser Gly Tyr Ser Gly Ser Phe Ser Ile Arg Gly Glu Thr Thr Gly Lys 
                405                 410                 415     


Asn Cys Thr Val Pro Cys Phe Trp Val Glu Met Ile Arg Gly Gln Pro 
            420                 425                 430         


Lys Glu Lys Thr Ile Trp Thr Ser Gly Ser Ser Ile Ala Phe Cys Gly 
        435                 440                 445             


Val Asp Ser Asp Thr Thr Gly Trp Ser Trp Pro Asp Gly Ala Leu Leu 
    450                 455                 460                 


Pro Phe Asp Ile Asp Lys 
465                 470 


<210>  38
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N4_rt

<400>  38

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Ile Ile 
1               5                   10                  15      


Leu Thr Thr Ile Gly Leu Leu Leu Gln Ile Thr Ser Leu Cys Ser Ile 
            20                  25                  30          


Trp Phe Ser His Tyr Asn Gln Val Thr Gln Thr His Glu Gln Pro Cys 
        35                  40                  45              


Ser Asn Asn Thr Thr Asn Tyr Tyr Asn Glu Thr Phe Val Asn Val Thr 
    50                  55                  60                  


Asn Val Gln Asn Asn Tyr Thr Thr Val Thr Glu Pro Ser Thr Pro Asp 
65                  70                  75                  80  


Val Val His Tyr Ser Ser Gly Arg Asp Leu Cys Pro Ile Arg Gly Trp 
                85                  90                  95      


Ala Pro Leu Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Arg Gly Glu 
            100                 105                 110         


Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Ile Ser Glu Cys 
        115                 120                 125             


Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser 
    130                 135                 140                 


Asn Gly Thr Val Lys Asp Arg Ser Pro Phe Arg Thr Leu Met Ser Cys 
145                 150                 155                 160 


Pro Ile Gly Val Ala Pro Ser Pro Ser Asn Ser Arg Phe Glu Ser Val 
                165                 170                 175     


Ala Trp Ser Ala Thr Ala Cys Ser Asp Gly Pro Gly Trp Leu Thr Leu 
            180                 185                 190         


Gly Ile Thr Gly Pro Asp Thr Thr Ala Val Ala Val Leu Lys Tyr Asn 
        195                 200                 205             


Gly Ile Ile Thr Asp Thr Phe Lys Ser Trp Lys Gly Asn Ile Met Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys Gln Asp Glu Phe Cys Tyr Thr Leu 
225                 230                 235                 240 


Ile Thr Asp Gly Pro Ser Asp Ala Gln Ala Phe Tyr Lys Ile Leu Lys 
                245                 250                 255     


Ile Arg Lys Gly Lys Ile Val Ser Met Lys Asp Val Asp Ala Thr Gly 
            260                 265                 270         


Phe His Phe Glu Glu Cys Ser Cys Tyr Pro Ser Arg Thr Asp Ile Glu 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Arg Gly Ser Asn Arg Pro Trp Ile Arg 
    290                 295                 300                 


Phe Asn Ser Asp Leu Asp Tyr Gln Ile Gly Tyr Val Cys Ser Gly Ile 
305                 310                 315                 320 


Phe Gly Asp Asn Pro Arg Pro Val Asp Gly Thr Gly Ser Cys Asn Ser 
                325                 330                 335     


Pro Val Asn Asn Gly Lys Gly Arg Tyr Gly Val Lys Gly Phe Ser Phe 
            340                 345                 350         


Arg Tyr Gly Asp Gly Val Trp Ile Gly Arg Thr Lys Ser Leu Glu Phe 
        355                 360                 365             


Arg Ser Gly Phe Glu Met Val Trp Asp Ala Asn Gly Trp Val Ser Thr 
    370                 375                 380                 


Asp Lys Asp Ser Asn Gly Val Gln Asp Ile Ile Asp Asn Asp Asn Trp 
385                 390                 395                 400 


Ser Gly Tyr Ser Gly Ser Phe Ser Ile Arg Gly Glu Lys Thr Gly Arg 
                405                 410                 415     


Asn Cys Thr Val Pro Cys Phe Trp Val Glu Met Ile Arg Gly Gln Pro 
            420                 425                 430         


Lys Glu Lys Thr Ile Trp Thr Ser Gly Ser Ser Ile Ala Phe Cys Gly 
        435                 440                 445             


Val Asn Ser Asp Thr Thr Gly Trp Ser Trp Pro Asp Gly Ala Leu Leu 
    450                 455                 460                 


Pro Phe Asp Ile Asp Lys 
465                 470 


<210>  39
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N5_aw

<400>  39

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Ala 
1               5                   10                  15      


Leu Val Val Phe Asn Ile Leu Leu His Ile Ala Ser Ile Val Ile Gly 
            20                  25                  30          


Ile Ile Ser Val Thr Lys Glu Ile Ser Val Ser Ser Thr Cys Asn Thr 
        35                  40                  45              


Thr Glu Val Tyr Asn Glu Thr Val Arg Leu Glu Thr Ile Thr Ile Pro 
    50                  55                  60                  


Ile Asn Asn Thr Val Tyr Ile Glu Arg Glu Ser His Gln Glu Pro Glu 
65                  70                  75                  80  


Phe Leu Asn Asn Thr Glu Pro Leu Cys Asn Val Ser Gly Phe Ala Ile 
                85                  90                  95      


Val Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Arg Gly His Val Phe 
            100                 105                 110         


Val Ile Arg Glu Pro Phe Val Ala Cys Gly Pro Thr Glu Cys Arg Thr 
        115                 120                 125             


Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Asn 
    130                 135                 140                 


Thr Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser Val Pro Leu 
145                 150                 155                 160 


Gly Ser Ser Pro Asn Ala Tyr Gln Ala Lys Phe Glu Ser Val Ala Trp 
                165                 170                 175     


Ser Ala Thr Ala Cys His Asp Gly Lys Gly Trp Leu Ala Val Gly Ile 
            180                 185                 190         


Ser Gly Ala Asp Asp Asp Ala Tyr Ala Val Ile His Tyr Gly Gly Met 
        195                 200                 205             


Pro Thr Asp Val Val Arg Ser Trp Arg Lys Gln Ile Leu Arg Thr Gln 
    210                 215                 220                 


Glu Ser Ser Cys Val Cys Met Thr Gly Asn Cys Tyr Trp Val Met Thr 
225                 230                 235                 240 


Asp Gly Pro Ala Asn Ser Gln Ala Ser Tyr Lys Ile Phe Lys Ser His 
                245                 250                 255     


Arg Gly Met Val Thr Asn Glu Arg Glu Val Ser Phe Gln Gly Gly His 
            260                 265                 270         


Ile Glu Glu Cys Ser Cys Tyr Pro Asn Leu Gly Lys Val Glu Cys Val 
        275                 280                 285             


Cys Arg Asp Asn Trp Asn Gly Met Asn Arg Pro Val Leu Thr Phe Asp 
    290                 295                 300                 


Glu Asp Leu Asn Tyr Glu Val Gly Tyr Leu Cys Ala Gly Ile Pro Thr 
305                 310                 315                 320 


Asp Thr Pro Arg Val Gln Asp Asn Ser Phe Thr Gly Ser Cys Thr Asn 
                325                 330                 335     


Ala Val Gly Gly Ser Gly Thr Asn Asn Tyr Gly Val Lys Gly Phe Gly 
            340                 345                 350         


Phe Arg Gln Gly Asn Ser Val Trp Ala Gly Arg Thr Val Ser Ile Ser 
        355                 360                 365             


Ser Arg Ser Gly Phe Glu Ile Leu Leu Ile Glu Asp Gly Trp Ile Lys 
    370                 375                 380                 


Thr Ser Lys Asn Val Val Lys Lys Val Glu Val Leu Asn Asn Lys Asn 
385                 390                 395                 400 


Trp Ser Gly Tyr Ser Gly Ala Phe Thr Ile Pro Ile Thr Met Thr Ser 
                405                 410                 415     


Lys Gln Cys Leu Val Pro Cys Phe Trp Leu Glu Met Ile Arg Gly Lys 
            420                 425                 430         


Pro Glu Glu Arg Thr Ser Ile Trp Thr Ser Ser Ser Ser Thr Val Phe 
        435                 440                 445             


Cys Gly Val Ser Ser Glu Val Pro Gly Trp Ser Trp Asp Asp Gly Ala 
    450                 455                 460                 


Ile Leu Pro Phe Asp Ile Asp Lys Met 
465                 470             


<210>  40
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N5_md

<400>  40

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Ile Ser Leu Gly 
1               5                   10                  15      


Leu Val Val Phe Asn Ile Leu Leu His Val Ala Ser Ile Val Leu Gly 
            20                  25                  30          


Ile Ile Ser Val Thr Lys Asp His Gly Ala Tyr Thr Cys Asn Thr Thr 
        35                  40                  45              


Glu Val Tyr Asn Glu Thr Val Arg Val Glu Thr Val Thr Ile Pro Val 
    50                  55                  60                  


Asn Asn Thr Ile Tyr Ile Glu Arg Glu Leu Thr His Glu Pro Glu Phe 
65                  70                  75                  80  


Leu Asn Asn Thr Glu Pro Leu Cys Glu Val Ser Gly Phe Ala Ile Val 
                85                  90                  95      


Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Arg Gly His Val Phe Val 
            100                 105                 110         


Ile Arg Glu Pro Phe Val Ala Cys Gly Pro Ser Glu Cys Arg Thr Phe 
        115                 120                 125             


Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Asn Thr 
    130                 135                 140                 


Val Lys Asp Arg Ser Pro Tyr Arg Ala Leu Met Ser Val Pro Leu Gly 
145                 150                 155                 160 


Ser Ser Pro Asn Ala Tyr Gln Ala Lys Phe Glu Ser Val Gly Trp Ser 
                165                 170                 175     


Ala Thr Ala Cys His Asp Gly Lys Glu Trp Met Ala Ile Gly Val Ser 
            180                 185                 190         


Gly Ala Asp Asp Asp Ala Tyr Ala Val Ile His Tyr Gly Gly Ile Pro 
        195                 200                 205             


Thr Asp Val Val Arg Ser Trp Arg Lys Gln Ile Leu Arg Thr Gln Glu 
    210                 215                 220                 


Ser Ser Cys Val Cys Met Lys Gly Glu Cys Tyr Trp Val Met Thr Asp 
225                 230                 235                 240 


Gly Pro Ala Asn Asn Gln Ala Ser Tyr Lys Ile Phe Lys Ser Gln Lys 
                245                 250                 255     


Gly Leu Val Val Asp Glu Lys Glu Ile Ser Phe Gln Gly Gly His Ile 
            260                 265                 270         


Glu Glu Cys Ser Cys Tyr Pro Asn Met Gly Lys Val Glu Cys Val Cys 
        275                 280                 285             


Arg Asp Asn Trp Asn Gly Met Asn Arg Pro Ile Leu Thr Phe Asp Glu 
    290                 295                 300                 


Asn Leu Glu Tyr Glu Val Gly Tyr Leu Cys Ala Gly Ile Pro Thr Asp 
305                 310                 315                 320 


Thr Pro Arg Val Gln Asp Ser Ser Phe Thr Gly Ser Cys Thr Asn Ala 
                325                 330                 335     


Val Gly Gly Ser Gly Thr Asn Asn Tyr Gly Val Lys Gly Phe Gly Phe 
            340                 345                 350         


Arg Gln Gly Thr Ser Val Trp Ala Gly Arg Thr Ile Ser Ile Ser Ser 
        355                 360                 365             


Arg Ser Gly Phe Glu Val Leu Leu Ile Lys Asp Gly Trp Ile Arg Pro 
    370                 375                 380                 


Ser Lys Thr Ile Ser Lys Lys Val Glu Val Leu Asp Asn Lys Asn Trp 
385                 390                 395                 400 


Ser Gly Tyr Ser Gly Ser Phe Thr Ile Pro Thr Ala Met Thr Ser Lys 
                405                 410                 415     


Ser Cys Leu Val Pro Cys Phe Trp Leu Glu Met Ile Arg Gly Lys Pro 
            420                 425                 430         


Glu Glu Arg Thr Ser Ile Trp Thr Ser Ser Ser Ser Thr Val Phe Cys 
        435                 440                 445             


Gly Val Ser Ser Glu Val Pro Gly Trp Ser Trp Asp Asp Gly Ala Ile 
    450                 455                 460                 


Leu Pro Phe Asp Ile Asp Lys Met 
465                 470         


<210>  41
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N6_Sz

<400>  41

Met Asn Pro Asn Gln Lys Ile Thr Cys Ile Ser Ala Thr Gly Val Thr 
1               5                   10                  15      


Leu Ser Val Val Ser Leu Leu Ile Gly Ile Ala Asn Leu Gly Leu Asn 
            20                  25                  30          


Ile Gly Leu His Tyr Lys Val Ser Asp Ser Thr Thr Ile Asn Ile Pro 
        35                  40                  45              


Asn Met Asn Glu Thr Asn Ser Thr Thr Thr Asn Ile Thr Asn Ile Ile 
    50                  55                  60                  


Val Asn Lys Asn Glu Glu Arg Thr Phe Leu Asn Leu Thr Lys Pro Leu 
65                  70                  75                  80  


Cys Glu Val Asn Ser Trp His Ile Leu Ser Lys Asp Asn Ala Ile Arg 
                85                  90                  95      


Ile Gly Glu Asp Ala His Ile Leu Val Thr Arg Glu Pro Tyr Leu Ser 
            100                 105                 110         


Cys Asp Pro Gln Gly Cys Arg Met Phe Ala Leu Ser Gln Gly Thr Thr 
        115                 120                 125             


Leu Arg Gly Arg His Ala Asn Gly Thr Ile His Asp Arg Gly Pro Phe 
    130                 135                 140                 


Arg Ala Leu Ile Ser Trp Glu Met Gly Gln Ala Pro Ser Pro Tyr Asn 
145                 150                 155                 160 


Thr Arg Val Glu Cys Ile Gly Trp Ser Ser Thr Ser Cys His Asp Gly 
                165                 170                 175     


Ile Ser Arg Met Ser Ile Cys Ile Ser Gly Pro Asn Asp Asn Ala Ser 
            180                 185                 190         


Ala Val Val Trp Tyr Arg Gly Arg Pro Val Thr Glu Ile Pro Ser Trp 
        195                 200                 205             


Val Gly Asn Ile Leu Arg Thr Gln Glu Ser Glu Cys Val Cys His Lys 
    210                 215                 220                 


Gly Ile Cys Pro Val Val Met Thr Asp Gly Pro Ala Asn Asn Lys Ala 
225                 230                 235                 240 


Ala Thr Lys Ile Ile Tyr Phe Lys Glu Gly Lys Ile Gln Lys Ile Glu 
                245                 250                 255     


Glu Leu Gln Gly Asn Ala Gln His Ile Glu Glu Cys Ser Cys Tyr Gly 
            260                 265                 270         


Ala Ala Gly Met Ile Lys Cys Val Cys Arg Asp Asn Trp Lys Gly Ala 
        275                 280                 285             


Asn Arg Pro Ile Ile Thr Ile Asp Pro Glu Met Met Thr His Thr Ser 
    290                 295                 300                 


Lys Tyr Leu Cys Ser Lys Ile Leu Thr Asp Thr Ser Arg Pro Asn Asp 
305                 310                 315                 320 


Pro Thr Asn Gly Asn Cys Asp Ala Pro Ile Thr Gly Gly Ser Pro Asp 
                325                 330                 335     


Pro Gly Val Lys Gly Phe Ala Phe Leu Asp Gly Glu Asn Ser Trp Leu 
            340                 345                 350         


Gly Arg Thr Ile Ser Lys Asp Ser Arg Ser Gly Tyr Glu Met Leu Lys 
        355                 360                 365             


Val Pro Asn Ala Glu Thr Asp Thr Gln Ser Gly Pro Thr Ser Tyr Gln 
    370                 375                 380                 


Leu Ile Val Asn Asn Gln Asn Trp Ser Gly Tyr Ser Gly Ala Phe Ile 
385                 390                 395                 400 


Asp Tyr Trp Ala Asn Lys Gly Cys Phe Asn Pro Cys Phe Tyr Val Glu 
                405                 410                 415     


Leu Ile Arg Gly Arg Pro Lys Glu Ile Asp Val Leu Trp Thr Ser Ser 
            420                 425                 430         


Ser Met Val Ala Leu Cys Gly Ser Arg Glu Arg Leu Gly Ser Trp Ser 
        435                 440                 445             


Trp His Asp Gly Ala Glu Ile Ile Tyr Phe Lys 
    450                 455                 


<210>  42
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N6_cs

<400>  42

Met Asn Pro Asn Gln Lys Ile Ile Cys Ile Ser Ala Thr Gly Met Thr 
1               5                   10                  15      


Leu Ser Val Val Ser Leu Leu Ile Gly Ile Ala Asn Leu Gly Leu Asn 
            20                  25                  30          


Ile Gly Leu His Tyr Lys Val Gly Asp Thr Pro Asp Val Asn Ile Pro 
        35                  40                  45              


Ser Met Asn Glu Thr Asn Ser Thr Thr Thr Ile Ile Asn Asn Asn Thr 
    50                  55                  60                  


Gln Asn Asn Phe Thr Asn Ile Thr Asn Ile Ile Val Asn Lys Glu Glu 
65                  70                  75                  80  


Gly Arg Thr Phe Leu Asn Leu Thr Lys Pro Leu Cys Glu Val Asn Ser 
                85                  90                  95      


Trp His Ile Leu Ser Lys Asp Asn Ala Ile Arg Ile Gly Glu Asp Ala 
            100                 105                 110         


His Ile Leu Val Thr Arg Glu Pro Tyr Leu Ser Cys Asp Pro Gln Gly 
        115                 120                 125             


Cys Arg Met Phe Ala Leu Ser Gln Gly Thr Thr Leu Arg Gly Arg His 
    130                 135                 140                 


Ala Asn Gly Thr Ile His Asp Arg Ser Pro Phe Arg Ala Leu Val Ser 
145                 150                 155                 160 


Trp Glu Met Gly Gln Ala Pro Ser Pro Tyr Asn Val Arg Val Glu Cys 
                165                 170                 175     


Ile Gly Trp Ser Ser Thr Ser Cys His Asp Gly Ile Ser Arg Met Ser 
            180                 185                 190         


Ile Cys Met Ser Gly Pro Asn Asn Asn Ala Ser Ala Val Val Trp Tyr 
        195                 200                 205             


Gly Gly Arg Pro Val Thr Glu Ile Pro Ser Trp Ala Gly Asn Ile Leu 
    210                 215                 220                 


Arg Thr Gln Glu Ser Glu Cys Val Cys His Lys Gly Ile Cys Pro Val 
225                 230                 235                 240 


Val Met Thr Asp Gly Pro Ala Asn Asn Arg Ala Ala Thr Lys Ile Ile 
                245                 250                 255     


Tyr Phe Lys Glu Gly Lys Ile Gln Lys Ile Glu Glu Leu Glu Gly Asn 
            260                 265                 270         


Ala Gln His Ile Glu Glu Cys Ser Cys Tyr Gly Ala Ala Gly Val Ile 
        275                 280                 285             


Lys Cys Ile Cys Arg Asp Asn Trp Lys Gly Ala Asn Arg Pro Val Ile 
    290                 295                 300                 


Ile Ile Asp Pro Glu Met Met Thr His Thr Ser Lys Tyr Leu Cys Ser 
305                 310                 315                 320 


Arg Val Leu Thr Asp Thr Ser Arg Pro Asn Asp Pro Thr Ser Gly Asn 
                325                 330                 335     


Cys Asp Ala Pro Ile Thr Gly Gly Ser Pro Asp Pro Gly Val Lys Gly 
            340                 345                 350         


Phe Ala Phe Leu Asp Gly Glu Asn Ser Trp Leu Gly Arg Thr Ile Ser 
        355                 360                 365             


Lys Asp Ser Arg Ser Gly Tyr Glu Met Leu Lys Val Pro Asn Ala Glu 
    370                 375                 380                 


Thr Asp Thr Gln Ser Gly Pro Thr Ser His Gln Val Ile Val Asn Asn 
385                 390                 395                 400 


Gln Asn Trp Ser Gly Tyr Ser Gly Ala Phe Ile Asp Tyr Trp Ala Asn 
                405                 410                 415     


Lys Glu Cys Phe Asn Pro Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg 
            420                 425                 430         


Pro Lys Glu Ser Ser Val Leu Trp Thr Ser Asn Ser Ile Val Ala Leu 
        435                 440                 445             


Cys Gly Ser Lys Glu Arg Leu Gly Ser Trp Ser Trp His Asp Gly Ala 
    450                 455                 460                 


Glu Ile Ile Tyr Phe Lys 
465                 470 


<210>  43
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N7_cN

<400>  43

Met Asn Pro Asn Gln Lys Leu Phe Ala Leu Ser Gly Val Ala Ile Ala 
1               5                   10                  15      


Leu Ser Val Leu Asn Leu Leu Ile Gly Ile Ser Asn Val Gly Leu Asn 
            20                  25                  30          


Val Ser Leu His Leu Lys Glu Lys Gly Pro Lys Gln Glu Glu Asn Leu 
        35                  40                  45              


Thr Cys Thr Thr Ile Asn Gln Asn Asn Thr Thr Val Val Glu Asn Thr 
    50                  55                  60                  


Tyr Val Asn Asn Thr Thr Ile Ile Thr Lys Gly Thr Asp Leu Lys Thr 
65                  70                  75                  80  


Pro Ser Tyr Leu Leu Leu Asn Lys Ser Leu Cys Asn Val Glu Gly Trp 
                85                  90                  95      


Val Val Ile Ala Lys Asp Asn Ala Val Arg Phe Gly Glu Ser Glu Gln 
            100                 105                 110         


Ile Ile Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Thr Gly Cys 
        115                 120                 125             


Lys Met Tyr Ala Leu His Gln Gly Thr Thr Ile Arg Asn Lys His Ser 
    130                 135                 140                 


Asn Gly Thr Ile His Asp Arg Thr Ala Phe Arg Gly Leu Ile Ser Thr 
145                 150                 155                 160 


Pro Leu Gly Thr Pro Pro Thr Val Ser Asn Ser Asp Phe Met Cys Val 
                165                 170                 175     


Gly Trp Ser Ser Thr Thr Cys His Asp Gly Ile Ala Arg Met Thr Ile 
            180                 185                 190         


Cys Ile Gln Gly Asn Asn Asp Asn Ala Thr Ala Thr Val Tyr Tyr Asn 
        195                 200                 205             


Arg Arg Leu Thr Thr Thr Ile Lys Thr Trp Ala Arg Asn Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys His Asn Gly Thr Cys Ala Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Ser Gln Ala Tyr Thr Lys Val Met Tyr 
                245                 250                 255     


Phe His Lys Gly Leu Val Val Lys Glu Glu Glu Leu Arg Gly Ser Ala 
            260                 265                 270         


Arg His Ile Glu Glu Cys Ser Cys Tyr Gly His Asn Gln Lys Val Thr 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Gln Gly Ala Asn Arg Pro Ile Ile Glu 
    290                 295                 300                 


Ile Asp Met Asn Thr Leu Glu His Thr Ser Arg Tyr Val Cys Thr Gly 
305                 310                 315                 320 


Ile Leu Thr Asp Thr Ser Arg Pro Gly Asp Lys Ser Ser Gly Asp Cys 
                325                 330                 335     


Ser Asn Pro Ile Thr Gly Ser Pro Gly Ala Pro Gly Val Lys Gly Phe 
            340                 345                 350         


Gly Phe Leu Asn Gly Asp Asn Thr Trp Leu Gly Arg Thr Ile Ser Pro 
        355                 360                 365             


Arg Ser Arg Ser Gly Phe Glu Met Leu Lys Ile Pro Asn Ala Gly Thr 
    370                 375                 380                 


Asp Pro Asn Ser Arg Ile Ala Glu Arg Gln Glu Ile Val Asp Asn Asn 
385                 390                 395                 400 


Asn Trp Ser Gly Tyr Ser Gly Ser Phe Ile Asp Tyr Trp Asn Asp Asn 
                405                 410                 415     


Ser Glu Cys Tyr Asn Pro Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg 
            420                 425                 430         


Pro Glu Glu Ala Lys Tyr Val Trp Trp Thr Ser Asn Ser Leu Ile Ala 
        435                 440                 445             


Leu Cys Gly Ser Pro Phe Pro Val Gly Pro Gly Ser Phe Pro Asp Gly 
    450                 455                 460                 


Ala Gln Ile Gln Tyr Phe Ser 
465                 470     


<210>  44
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N7_cG

<400>  44

Met Asn Pro Asn Gln Lys Leu Phe Ala Leu Ser Gly Val Ala Ile Ala 
1               5                   10                  15      


Leu Ser Val Leu Asn Leu Leu Ile Gly Ile Ser Asn Val Gly Leu Asn 
            20                  25                  30          


Val Ser Leu His Leu Lys Glu Lys Gly Pro Lys Gln Glu Glu Asn Leu 
        35                  40                  45              


Thr Cys Thr Thr Ile Asn Gln Asn Asn Thr Thr Val Val Glu Asn Thr 
    50                  55                  60                  


Tyr Val Asn Asn Thr Thr Ile Ile Thr Lys Gly Thr Asp Leu Lys Thr 
65                  70                  75                  80  


Pro Ser Tyr Leu Leu Leu Asn Lys Ser Leu Cys Asn Val Glu Gly Trp 
                85                  90                  95      


Val Val Ile Ala Lys Asp Asn Ala Val Arg Phe Gly Glu Ser Glu Gln 
            100                 105                 110         


Ile Ile Val Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Thr Gly Cys 
        115                 120                 125             


Lys Met Tyr Ala Leu His Gln Gly Thr Thr Ile Arg Asn Lys His Ser 
    130                 135                 140                 


Asn Gly Thr Ile His Asp Arg Thr Ala Phe Arg Gly Leu Ile Ser Thr 
145                 150                 155                 160 


Pro Leu Gly Thr Pro Pro Thr Val Ser Asn Ser Asp Phe Met Cys Val 
                165                 170                 175     


Gly Trp Ser Ser Thr Thr Cys His Asp Gly Ile Ala Arg Met Thr Ile 
            180                 185                 190         


Cys Ile Gln Gly Asn Asn Asp Asn Ala Thr Ala Thr Val Tyr Tyr Asn 
        195                 200                 205             


Arg Arg Leu Thr Thr Thr Ile Lys Thr Trp Ala Arg Asn Ile Leu Arg 
    210                 215                 220                 


Thr Gln Glu Ser Glu Cys Val Cys His Asn Gly Thr Cys Ala Val Val 
225                 230                 235                 240 


Met Thr Asp Gly Ser Ala Ser Ser Gln Ala Tyr Thr Lys Val Met Tyr 
                245                 250                 255     


Phe His Lys Gly Leu Val Val Lys Glu Glu Glu Leu Arg Gly Ser Ala 
            260                 265                 270         


Arg His Ile Glu Glu Cys Ser Cys Tyr Gly His Asn Gln Lys Val Thr 
        275                 280                 285             


Cys Val Cys Arg Asp Asn Trp Gln Gly Ala Asn Arg Pro Ile Ile Glu 
    290                 295                 300                 


Ile Asp Met Asn Thr Leu Glu His Thr Ser Arg Tyr Val Cys Thr Gly 
305                 310                 315                 320 


Ile Leu Thr Asp Thr Ser Arg Pro Gly Asp Lys Ser Ser Gly Asp Cys 
                325                 330                 335     


Ser Asn Pro Ile Thr Gly Ser Pro Gly Ala Pro Gly Val Lys Gly Phe 
            340                 345                 350         


Gly Phe Leu Asn Gly Asp Asn Thr Trp Leu Gly Arg Thr Ile Ser Pro 
        355                 360                 365             


Arg Ser Arg Ser Gly Phe Glu Met Leu Lys Ile Pro Asn Ala Gly Thr 
    370                 375                 380                 


Asp Pro Asn Ser Arg Ile Ala Glu Arg Gln Glu Ile Val Asp Asn Asn 
385                 390                 395                 400 


Asn Trp Ser Gly Tyr Ser Gly Ser Phe Ile Asp Tyr Trp Asn Asp Asn 
                405                 410                 415     


Ser Glu Cys Tyr Asn Pro Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg 
            420                 425                 430         


Pro Glu Glu Ala Lys Tyr Val Trp Trp Ala Ser Asn Ser Leu Ile Ala 
        435                 440                 445             


Leu Cys Gly Ser Pro Phe Pro Val Gly Ser Gly Ser Phe Pro Asp Gly 
    450                 455                 460                 


Ala Gln Ile Gln Tyr Phe Ser 
465                 470     


<210>  45
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N8_cN

<400>  45

Met Asn Pro Asn Gln Lys Ile Val Thr Ile Gly Ser Ile Ser Leu Gly 
1               5                   10                  15      


Leu Val Val Phe Asn Val Leu Leu His Ala Val Ser Ile Ile Leu Thr 
            20                  25                  30          


Val Leu Ala Leu Gly Lys Ser Glu Asn Asn Gly Ile Cys Asn Gly Thr 
        35                  40                  45              


Val Val Arg Glu Tyr Asn Glu Thr Val Arg Ile Glu Lys Val Thr Gln 
    50                  55                  60                  


Trp Tyr Asn Thr Ser Val Val Glu Tyr Val Pro His Trp Asn Glu Gly 
65                  70                  75                  80  


Thr Tyr Ile Asn Asn Thr Glu Pro Ile Cys Asp Val Lys Gly Phe Ala 
                85                  90                  95      


Pro Phe Ser Lys Asp Asn Gly Ile Arg Val Gly Ser Arg Gly His Ile 
            100                 105                 110         


Phe Val Ile Arg Glu Pro Phe Val Ser Cys Ser Pro Val Glu Cys Arg 
        115                 120                 125             


Thr Phe Phe Leu Thr Gln Gly Ser Leu Leu Asn Asp Lys His Ser Asn 
    130                 135                 140                 


Gly Thr Val Lys Asp Arg Ser Pro Phe Arg Thr Leu Met Ser Val Glu 
145                 150                 155                 160 


Val Gly Gln Ser Pro Asn Val Tyr Gln Ala Arg Phe Glu Ala Val Ala 
                165                 170                 175     


Trp Ser Ala Thr Ala Cys His Asp Gly Lys Lys Trp Met Thr Ile Gly 
            180                 185                 190         


Val Thr Gly Pro Asp Ser Lys Ala Val Ala Val Val His Tyr Gly Gly 
        195                 200                 205             


Val Pro Thr Asp Val Val Asn Ser Trp Ala Gly Asp Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ser Cys Thr Cys Ile Gln Gly Asn Cys Tyr Trp Val Met 
225                 230                 235                 240 


Thr Asp Gly Pro Ala Asn Arg Gln Ala Gln Tyr Arg Ile Tyr Lys Ala 
                245                 250                 255     


Asn Gln Gly Lys Ile Ile Gly Arg Thr Asp Val Ser Phe Ser Gly Gly 
            260                 265                 270         


His Ile Glu Glu Cys Ser Cys Tyr Pro Asn Asp Gly Lys Val Glu Cys 
        275                 280                 285             


Val Cys Arg Asp Asn Trp Thr Gly Thr Asn Arg Pro Val Leu Ile Ile 
    290                 295                 300                 


Ser Pro Asp Leu Ser Tyr Arg Val Gly Tyr Leu Cys Ala Gly Leu Pro 
305                 310                 315                 320 


Ser Asp Thr Pro Arg Gly Glu Asp Thr Gln Phe Ala Gly Ser Cys Thr 
                325                 330                 335     


Ser Pro Met Gly Asn Gln Gly Tyr Gly Val Lys Gly Phe Gly Phe Arg 
            340                 345                 350         


Gln Gly Thr Asp Val Trp Val Gly Arg Thr Ile Ser Arg Thr Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Ile Ile Arg Ile Lys Asn Gly Trp Thr Gln Thr Ser 
    370                 375                 380                 


Lys Glu Gln Ile Arg Arg Gln Val Val Val Asp Asn Ser Asn Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Thr Leu Pro Val Glu Leu Ser Gly Arg Glu 
                405                 410                 415     


Cys Leu Val Pro Cys Phe Trp Val Glu Met Ile Arg Gly Arg Pro Glu 
            420                 425                 430         


Glu Arg Thr Ile Trp Thr Ser Ser Ser Ser Ile Val Met Cys Gly Val 
        435                 440                 445             


Asp Tyr Glu Ile Ala Asp Trp Ser Trp His Asp Gly Ala Ile Leu Pro 
    450                 455                 460                 


Phe Asp Ile Asp Lys Thr 
465                 470 


<210>  46
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N8_cL

<400>  46

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Gly 
1               5                   10                  15      


Leu Val Val Leu Asn Ile Leu Leu His Ile Val Ser Ile Thr Val Thr 
            20                  25                  30          


Val Leu Val Leu Pro Arg Asn Gly Asn Asn Gly Ser Cys Asn Glu Thr 
        35                  40                  45              


Val Ile Arg Glu Tyr Asn Glu Thr Val Arg Val Glu Lys Val Thr Gln 
    50                  55                  60                  


Trp His Asn Thr Asn Val Ile Glu Tyr Ile Glu Arg Pro Glu Asn Asp 
65                  70                  75                  80  


His Phe Met Asn Asn Thr Glu Ala Leu Cys Asp Ala Lys Gly Phe Ala 
                85                  90                  95      


Pro Phe Ser Lys Asp Asn Gly Ile Arg Ile Gly Ser Arg Gly His Val 
            100                 105                 110         


Phe Val Ile Arg Glu Pro Phe Val Ser Cys Ser Pro Thr Glu Cys Arg 
        115                 120                 125             


Thr Phe Phe Leu Thr Gln Gly Ser Leu Leu Asn Asp Lys His Ser Asn 
    130                 135                 140                 


Gly Thr Val Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Val Glu 
145                 150                 155                 160 


Ile Gly Gln Ser Pro Asn Val Tyr Gln Ala Arg Phe Glu Ala Val Ala 
                165                 170                 175     


Trp Ser Ala Thr Ala Cys His Asp Gly Lys Lys Trp Met Thr Ile Gly 
            180                 185                 190         


Val Thr Gly Pro Asp Ala Lys Ala Val Ala Val Val His Tyr Gly Gly 
        195                 200                 205             


Ile Pro Thr Asp Val Ile Asn Ser Trp Ala Gly Asp Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ser Cys Thr Cys Ile Gln Gly Glu Cys Phe Trp Val Met 
225                 230                 235                 240 


Thr Asp Gly Pro Ala Asn Arg Gln Ala Gln Tyr Arg Ala Phe Lys Ala 
                245                 250                 255     


Lys Gln Gly Lys Ile Val Gly Gln Ala Glu Ile Ser Phe Asn Gly Gly 
            260                 265                 270         


His Ile Glu Glu Cys Ser Cys Tyr Pro Asn Glu Gly Lys Val Glu Cys 
        275                 280                 285             


Val Cys Arg Asp Asn Trp Thr Gly Thr Asn Arg Pro Val Leu Val Ile 
    290                 295                 300                 


Ser Pro Asp Leu Ser Tyr Arg Val Gly Tyr Leu Cys Ala Gly Ile Pro 
305                 310                 315                 320 


Ser Asp Thr Pro Arg Gly Glu Asp Ser Gln Phe Thr Gly Ser Cys Thr 
                325                 330                 335     


Ser Pro Met Gly Asn Gln Gly Tyr Gly Val Lys Gly Phe Gly Phe Arg 
            340                 345                 350         


Gln Gly Ser Asp Val Trp Met Gly Arg Thr Ile Ser Arg Thr Ser Arg 
        355                 360                 365             


Ser Gly Phe Glu Ile Leu Lys Val Arg Asn Gly Trp Val Gln Asn Ser 
    370                 375                 380                 


Lys Glu Gln Ile Lys Arg Gln Val Val Val Asp Asn Leu Asn Trp Ser 
385                 390                 395                 400 


Gly Tyr Ser Gly Ser Phe Thr Leu Pro Val Glu Leu Thr Lys Arg Asn 
                405                 410                 415     


Cys Leu Val Pro Cys Phe Trp Val Glu Met Ile Arg Gly Lys Pro Glu 
            420                 425                 430         


Glu Lys Thr Ile Trp Thr Ser Ser Ser Ser Ile Val Met Cys Gly Val 
        435                 440                 445             


Asp His Glu Ile Ala Asp Trp Ser Trp His Asp Gly Ala Ile Leu Pro 
    450                 455                 460                 


Phe Asp Ile Asp Lys Met 
465                 470 


<210>  47
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N9_AH13

<400>  47

Met Asn Pro Asn Gln Lys Ile Leu Cys Thr Ser Ala Thr Ala Ile Ile 
1               5                   10                  15      


Ile Gly Ala Ile Ala Val Leu Ile Gly Ile Ala Asn Leu Gly Leu Asn 
            20                  25                  30          


Ile Gly Leu His Leu Lys Pro Gly Cys Asn Cys Ser His Ser Gln Pro 
        35                  40                  45              


Glu Thr Thr Asn Thr Ser Gln Thr Ile Ile Asn Asn Tyr Tyr Asn Glu 
    50                  55                  60                  


Thr Asn Ile Thr Asn Ile Gln Met Glu Glu Arg Thr Ser Arg Asn Phe 
65                  70                  75                  80  


Asn Asn Leu Thr Lys Gly Leu Cys Thr Ile Asn Ser Trp His Ile Tyr 
                85                  90                  95      


Gly Lys Asp Asn Ala Val Arg Ile Gly Glu Ser Ser Asp Val Leu Val 
            100                 105                 110         


Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Glu Cys Arg Phe Tyr 
        115                 120                 125             


Ala Leu Ser Gln Gly Thr Thr Ile Arg Gly Lys His Ser Asn Gly Thr 
    130                 135                 140                 


Ile His Asp Arg Ser Gln Tyr Arg Ala Leu Ile Ser Trp Pro Leu Ser 
145                 150                 155                 160 


Ser Pro Pro Thr Val Tyr Asn Ser Arg Val Glu Cys Ile Gly Trp Ser 
                165                 170                 175     


Ser Thr Ser Cys His Asp Gly Lys Ser Arg Met Ser Ile Cys Ile Ser 
            180                 185                 190         


Gly Pro Asn Asn Asn Ala Ser Ala Val Val Trp Tyr Asn Arg Arg Pro 
        195                 200                 205             


Val Ala Glu Ile Asn Thr Trp Ala Arg Asn Ile Leu Arg Thr Gln Glu 
    210                 215                 220                 


Ser Glu Cys Val Cys His Asn Gly Val Cys Pro Val Val Phe Thr Asp 
225                 230                 235                 240 


Gly Ser Ala Thr Gly Pro Ala Asp Thr Arg Ile Tyr Tyr Phe Lys Glu 
                245                 250                 255     


Gly Lys Ile Leu Lys Trp Glu Ser Leu Thr Gly Thr Ala Lys His Ile 
            260                 265                 270         


Glu Glu Cys Ser Cys Tyr Gly Glu Arg Thr Gly Ile Thr Cys Thr Cys 
        275                 280                 285             


Arg Asp Asn Trp Gln Gly Ser Asn Arg Pro Val Ile Gln Ile Asp Pro 
    290                 295                 300                 


Val Ala Met Thr His Thr Ser Gln Tyr Ile Cys Ser Pro Val Leu Thr 
305                 310                 315                 320 


Asp Asn Pro Arg Pro Asn Asp Pro Asn Ile Gly Lys Cys Asn Asp Pro 
                325                 330                 335     


Tyr Pro Gly Asn Asn Asn Asn Gly Val Lys Gly Phe Ser Tyr Leu Asp 
            340                 345                 350         


Gly Ala Asn Thr Trp Leu Gly Arg Thr Ile Ser Thr Ala Ser Arg Ser 
        355                 360                 365             


Gly Tyr Glu Met Leu Lys Val Pro Asn Ala Leu Thr Asp Asp Arg Ser 
    370                 375                 380                 


Lys Pro Ile Gln Gly Gln Thr Ile Val Leu Asn Ala Asp Trp Ser Gly 
385                 390                 395                 400 


Tyr Ser Gly Ser Phe Met Asp Tyr Trp Ala Glu Gly Asp Cys Tyr Arg 
                405                 410                 415     


Ala Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Asp Lys 
            420                 425                 430         


Val Trp Trp Thr Ser Asn Ser Ile Val Ser Met Cys Ser Ser Thr Glu 
        435                 440                 445             


Phe Leu Gly Gln Trp Asn Trp Pro Asp Gly Ala Lys Ile Glu Tyr Phe 
    450                 455                 460                 


Leu 
465 


<210>  48
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N9_ck

<400>  48

Met Asn Pro Asn Gln Lys Ile Leu Cys Thr Ser Ala Thr Ala Ile Ile 
1               5                   10                  15      


Ile Gly Ala Ile Ala Val Leu Ile Gly Ile Ala Asn Leu Gly Leu Asn 
            20                  25                  30          


Ile Gly Leu His Leu Lys Pro Gly Cys Asn Cys Ser His Ser Gln Pro 
        35                  40                  45              


Glu Thr Thr Asn Thr Ser Gln Thr Ile Ile Asn Asn Tyr Tyr Asn Glu 
    50                  55                  60                  


Thr Asn Ile Thr Asn Ile Gln Met Glu Glu Arg Thr Ser Lys Asn Phe 
65                  70                  75                  80  


Asn Asn Leu Thr Lys Gly Leu Cys Thr Ile Asn Ser Trp His Ile Tyr 
                85                  90                  95      


Gly Lys Asp Asn Ala Val Arg Ile Gly Glu Ser Ser Asp Val Leu Val 
            100                 105                 110         


Thr Arg Glu Pro Tyr Val Ser Cys Asp Pro Asp Glu Cys Arg Phe Tyr 
        115                 120                 125             


Ala Leu Ser Gln Gly Thr Thr Ile Arg Gly Lys His Ser Asn Gly Thr 
    130                 135                 140                 


Ile His Asp Arg Ser Gln Tyr Arg Ala Leu Ile Ser Trp Pro Leu Ser 
145                 150                 155                 160 


Ser Pro Pro Thr Val Tyr Asn Ser Arg Val Glu Cys Ile Gly Trp Ser 
                165                 170                 175     


Ser Thr Ser Cys His Asp Gly Lys Ser Arg Met Ser Ile Cys Ile Ser 
            180                 185                 190         


Gly Pro Asn Asn Asn Ala Ser Ala Val Val Trp Tyr Asn Arg Arg Pro 
        195                 200                 205             


Val Ala Glu Ile Asn Thr Trp Ala Arg Asn Ile Leu Arg Thr Gln Glu 
    210                 215                 220                 


Ser Glu Cys Val Cys His Asn Gly Val Cys Pro Val Val Phe Thr Asp 
225                 230                 235                 240 


Gly Ser Ala Thr Gly Pro Ala Asp Thr Arg Ile Tyr Tyr Phe Lys Glu 
                245                 250                 255     


Gly Lys Ile Leu Lys Trp Glu Ser Leu Thr Gly Thr Ala Lys His Ile 
            260                 265                 270         


Glu Glu Cys Ser Cys Tyr Gly Glu Arg Thr Gly Ile Thr Cys Thr Cys 
        275                 280                 285             


Arg Asp Asn Trp Gln Gly Ser Asn Arg Pro Val Ile Gln Ile Asp Pro 
    290                 295                 300                 


Val Ala Met Thr His Thr Ser Gln Tyr Ile Cys Ser Pro Val Leu Thr 
305                 310                 315                 320 


Asp Asn Pro Arg Pro Asn Asp Pro Asn Ile Gly Lys Cys Asn Asp Pro 
                325                 330                 335     


Tyr Pro Gly Asn Asn Asn Asn Gly Val Lys Gly Phe Ser Tyr Leu Asp 
            340                 345                 350         


Gly Ala Asn Thr Trp Leu Gly Arg Thr Ile Ser Thr Ala Ser Arg Ser 
        355                 360                 365             


Gly Tyr Glu Met Leu Lys Val Pro Asn Ala Leu Thr Asp Asp Arg Ser 
    370                 375                 380                 


Lys Pro Ile Gln Gly Gln Thr Ile Val Leu Asn Ala Asp Trp Ser Gly 
385                 390                 395                 400 


Tyr Ser Gly Ser Phe Met Asp Tyr Trp Ala Lys Gly Asp Cys Tyr Arg 
                405                 410                 415     


Ala Cys Phe Tyr Val Glu Leu Ile Arg Gly Arg Pro Lys Glu Asp Lys 
            420                 425                 430         


Val Trp Trp Thr Ser Asn Ser Ile Val Ser Met Cys Ser Ser Thr Glu 
        435                 440                 445             


Phe Leu Gly Gln Trp Asn Trp Pro Asp Gly Ala Lys Ile Glu Tyr Phe 
    450                 455                 460                 


Leu 
465 


<210>  49
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B_Mal

<400>  49

Met Leu Pro Ser Thr Ile Gln Thr Leu Thr Leu Phe Leu Thr Ser Gly 
1               5                   10                  15      


Gly Val Leu Leu Ser Leu Tyr Val Ser Ala Ser Leu Ser Tyr Leu Pro 
            20                  25                  30          


Tyr Ser Asp Ile Leu Leu Lys Phe Pro Ser Thr Glu Ile Thr Ala Pro 
        35                  40                  45              


Thr Met Pro Leu Asp Cys Ala Asn Ala Ser Asn Val Gln Ala Val Asn 
    50                  55                  60                  


Arg Ser Ala Thr Lys Gly Val Thr Leu Leu Leu Pro Glu Pro Glu Trp 
65                  70                  75                  80  


Thr Tyr Pro Arg Leu Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu 
                85                  90                  95      


Leu Ile Ser Pro His Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro 
            100                 105                 110         


Leu Ile Ile Arg Glu Pro Phe Ile Ala Cys Gly Pro Lys Glu Cys Lys 
        115                 120                 125             


His Phe Ala Leu Thr His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn 
    130                 135                 140                 


Gly Thr Arg Gly Asp Arg Asn Lys Leu Arg His Leu Ile Ser Val Lys 
145                 150                 155                 160 


Leu Gly Lys Ile Pro Thr Val Glu Asn Ser Ile Phe His Met Ala Ala 
                165                 170                 175     


Trp Ser Gly Ser Ala Cys His Asp Gly Lys Glu Trp Thr Tyr Ile Gly 
            180                 185                 190         


Val Asp Gly Pro Asp Asn Asn Ala Leu Leu Lys Ile Lys Tyr Gly Glu 
        195                 200                 205             


Ala Tyr Thr Asp Thr Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr 
    210                 215                 220                 


Gln Glu Ser Ala Cys Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met Ile 
225                 230                 235                 240 


Thr Asp Gly Ser Ala Ser Gly Val Ser Glu Cys Arg Phe Leu Lys Ile 
                245                 250                 255     


Arg Glu Gly Arg Ile Ile Lys Glu Ile Phe Pro Thr Gly Arg Ile Lys 
            260                 265                 270         


His Thr Glu Glu Cys Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile Glu 
        275                 280                 285             


Cys Ala Cys Arg Asp Asn Ser Tyr Thr Ala Lys Arg Pro Phe Val Lys 
    290                 295                 300                 


Leu Asn Val Glu Thr Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Glu 
305                 310                 315                 320 


Thr Tyr Leu Asp Thr Pro Arg Pro Asp Asp Gly Ser Ile Thr Gly Pro 
                325                 330                 335     


Cys Glu Ser Asn Gly Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe 
            340                 345                 350         


Val His Gln Arg Met Ala Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr 
        355                 360                 365             


Met Ser Lys Thr Lys Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Asp 
    370                 375                 380                 


Gly Asp Pro Trp Ala Asp Ser Asp Ala Leu Ala Phe Ser Gly Val Met 
385                 390                 395                 400 


Val Ser Met Glu Glu Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys 
                405                 410                 415     


Asp Lys Lys Cys Asp Val Pro Cys Ile Gly Ile Glu Met Val His Asp 
            420                 425                 430         


Gly Gly Lys Glu Thr Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu 
        435                 440                 445             


Met Gly Ser Gly Gln Leu Leu Trp Asp Thr Val Thr Gly Val Asn Met 
    450                 455                 460                 


Ala Leu 
465     


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  50

His His His His His His 
1               5       


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  51

Leu Val Pro Arg Gly Ser Pro 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is G or S

<400>  52

Glu Asn Leu Tyr Phe Gln Xaa 
1               5           


<210>  53
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PR8 N1 (aa 1-102)

<400>  53

Met Asn Pro Asn Gln Lys Ile Thr Thr Ile Gly Ser Ile Cys Leu Val 
1               5                   10                  15      


Val Gly Leu Ile Ser Leu Ile Leu Gln Ile Gly Asn Ile Ile Ser Ile 
            20                  25                  30          


Trp Ile Ser His Ser Ile Gln Thr Gly Ser Gln Asn His Thr Gly Ile 
        35                  40                  45              


Cys Asn Gln Asn Ile Ile Thr Tyr Lys Asn Ser Thr Trp Val Lys Asp 
    50                  55                  60                  


Thr Thr Ser Val Ile Leu Thr Gly Asn Ser Ser Leu Cys Pro Ile Arg 
65                  70                  75                  80  


Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Ile Arg Ile Gly Ser Lys 
                85                  90                  95      


Gly Asp Val Phe Val Ile 
            100         


<210>  54
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HK14 N2 (aa 1-117)

<400>  54

Met Asn Pro Asn Gln Lys Ile Ile Thr Ile Gly Ser Val Ser Leu Thr 
1               5                   10                  15      


Ile Ser Thr Ile Cys Phe Phe Met Gln Ile Ala Ile Leu Ile Thr Thr 
            20                  25                  30          


Val Thr Leu His Phe Lys Gln Tyr Glu Phe Asn Ser Pro Pro Asn Asn 
        35                  40                  45              


Gln Val Met Leu Cys Glu Pro Thr Ile Ile Glu Arg Asn Ile Thr Glu 
    50                  55                  60                  


Ile Val Tyr Leu Thr Asn Thr Thr Ile Glu Lys Glu Ile Cys Pro Lys 
65                  70                  75                  80  


Pro Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys Gly Ile Thr Gly 
                85                  90                  95      


Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu Ser Ala Gly Gly 
            100                 105                 110         


Asp Ile Trp Val Thr 
        115         


<210>  55
<211>  1539
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1-MPP (with his tag)

<400>  55
atgctgctcg tcaaccaatc ccaccagggc ttcaacaagg aacacacttc taagatggtc       60

tccgctatcg tgctctacgt gctgctcgct gccgctgccc actcagcttt cgctgccgac      120

ccacaccacc accaccacca cggcgatcac tacgacgacg aactgttctc cgacgtgcag      180

gacatcaaga ccgctctggc taagatccac gaggacaacc agaagatcat ctccaagctg      240

gaatccctgc tgctgctgaa gggcgaagtc gagtccatca agaagcagat caaccgccag      300

aacatctcca tctccacctt ggagggtcac ctgtcctcca tcatgatcgc tatccctggc      360

ctgggcggcg gctccgtgaa attagcgggc aattcctctc tctgccctgt tagtggatgg      420

gctatataca gtaaagacaa cagtgtaaga atcggttcca agggggatgt gtttgtcata      480

agggaaccat tcatatcatg ctctcccttg gaatgcagaa ccttcttctt gactcaaggg      540

gccttgctaa atgacaaaca ttccaatgga accattaaag acaggagccc ataccgaacc      600

ctaatgagct gtcctattgg tgaagttccc tctccataca actcaagatt tgagtcagtc      660

gcttggtcag caagtgcttg tcatgatggc atcaattggc taacaattgg aatttctggc      720

ccagacagtg gggcagtggc tgtgttaaag tacaatggca taataacaga cactatcaag      780

agttggagga acaatatatt gagaacacaa gagtctgaat gtgcatgtgt aaatggttct      840

tgctttacca taatgaccga tggaccaagt gatggacagg cctcatacaa aatcttcaga      900

atagaaaagg gaaagataat caaatcagtc gaaatgaaag cccctaatta tcactatgag      960

gaatgctcct gttaccctga ttctagtgaa atcacatgtg tgtgcaggga taactggcat     1020

ggctcgaatc gaccgtgggt gtctttcaac cagaatctgg aatatcagat gggatacata     1080

tgcagtgggg ttttcggaga caatccacgc cctaatgata agacaggcag ttgtggtcca     1140

gtatcgtcta atggagcaaa tggagtaaaa ggattttcat tcaaatacgg caatggtgtt     1200

tggataggga gaactaaaag cattagttca agaaaaggtt ttgagatgat ttgggatccg     1260

aatggatgga ctgggactga caataaattc tcaataaagc aagatatcgt aggaataaat     1320

gagtggtcag ggtatagcgg gagttttgtt cagcatccag aactaacagg gctggattgt     1380

ataagacctt gcttctgggt tgaactaata agagggcgac ccgaagagaa cacaatctgg     1440

actagcggga gcagcatatc cttttgtggt gtaaacagtg acactgtggg ttggtcttgg     1500

ccagacggtg ctgagttgcc atttaccatt gacaagtaa                            1539


<210>  56
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1-MPP (with his tag)

<400>  56

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Gly 
        35                  40                  45              


Asp His Tyr Asp Asp Glu Leu Phe Ser Asp Val Gln Asp Ile Lys Thr 
    50                  55                  60                  


Ala Leu Ala Lys Ile His Glu Asp Asn Gln Lys Ile Ile Ser Lys Leu 
65                  70                  75                  80  


Glu Ser Leu Leu Leu Leu Lys Gly Glu Val Glu Ser Ile Lys Lys Gln 
                85                  90                  95      


Ile Asn Arg Gln Asn Ile Ser Ile Ser Thr Leu Glu Gly His Leu Ser 
            100                 105                 110         


Ser Ile Met Ile Ala Ile Pro Gly Leu Gly Gly Gly Ser Val Lys Leu 
        115                 120                 125             


Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp Ala Ile Tyr Ser 
    130                 135                 140                 


Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp Val Phe Val Ile 
145                 150                 155                 160 


Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys Arg Thr Phe Phe 
                165                 170                 175     


Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser Asn Gly Thr Ile 
            180                 185                 190         


Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys Pro Ile Gly Glu 
        195                 200                 205             


Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val Ala Trp Ser Ala 
    210                 215                 220                 


Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile Gly Ile Ser Gly 
225                 230                 235                 240 


Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn Gly Ile Ile Thr 
                245                 250                 255     


Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg Thr Gln Glu Ser 
            260                 265                 270         


Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile Met Thr Asp Gly 
        275                 280                 285             


Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg Ile Glu Lys Gly 
    290                 295                 300                 


Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn Tyr His Tyr Glu 
305                 310                 315                 320 


Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr Cys Val Cys Arg 
                325                 330                 335     


Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser Phe Asn Gln Asn 
            340                 345                 350         


Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val Phe Gly Asp Asn 
        355                 360                 365             


Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro Val Ser Ser Asn 
    370                 375                 380                 


Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr Gly Asn Gly Val 
385                 390                 395                 400 


Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys Gly Phe Glu Met 
                405                 410                 415     


Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn Lys Phe Ser Ile 
            420                 425                 430         


Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly Tyr Ser Gly Ser 
        435                 440                 445             


Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys Ile Arg Pro Cys 
    450                 455                 460                 


Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu Asn Thr Ile Trp 
465                 470                 475                 480 


Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn Ser Asp Thr Val 
                485                 490                 495     


Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe Thr Ile Asp Lys 
            500                 505                 510         


<210>  57
<211>  1521
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N1-MPP (no his tag)

<400>  57
atgctgctcg tcaaccaatc ccaccagggc ttcaacaagg aacacacttc taagatggtc       60

tccgctatcg tgctctacgt gctgctcgct gccgctgccc actcagcttt cgctgccgac      120

ccaggcgatc actacgacga cgaactgttc tccgacgtgc aggacatcaa gaccgctctg      180

gctaagatcc acgaggacaa ccagaagatc atctccaagc tggaatccct gctgctgctg      240

aagggcgaag tcgagtccat caagaagcag atcaaccgcc agaacatctc catctccacc      300

ttggagggtc acctgtcctc catcatgatc gctatccctg gcctgggcgg cggctccgtg      360

aaattagcgg gcaattcctc tctctgccct gttagtggat gggctatata cagtaaagac      420

aacagtgtaa gaatcggttc caagggggat gtgtttgtca taagggaacc attcatatca      480

tgctctccct tggaatgcag aaccttcttc ttgactcaag gggccttgct aaatgacaaa      540

cattccaatg gaaccattaa agacaggagc ccataccgaa ccctaatgag ctgtcctatt      600

ggtgaagttc cctctccata caactcaaga tttgagtcag tcgcttggtc agcaagtgct      660

tgtcatgatg gcatcaattg gctaacaatt ggaatttctg gcccagacag tggggcagtg      720

gctgtgttaa agtacaatgg cataataaca gacactatca agagttggag gaacaatata      780

ttgagaacac aagagtctga atgtgcatgt gtaaatggtt cttgctttac cataatgacc      840

gatggaccaa gtgatggaca ggcctcatac aaaatcttca gaatagaaaa gggaaagata      900

atcaaatcag tcgaaatgaa agcccctaat tatcactatg aggaatgctc ctgttaccct      960

gattctagtg aaatcacatg tgtgtgcagg gataactggc atggctcgaa tcgaccgtgg     1020

gtgtctttca accagaatct ggaatatcag atgggataca tatgcagtgg ggttttcgga     1080

gacaatccac gccctaatga taagacaggc agttgtggtc cagtatcgtc taatggagca     1140

aatggagtaa aaggattttc attcaaatac ggcaatggtg tttggatagg gagaactaaa     1200

agcattagtt caagaaaagg ttttgagatg atttgggatc cgaatggatg gactgggact     1260

gacaataaat tctcaataaa gcaagatatc gtaggaataa atgagtggtc agggtatagc     1320

gggagttttg ttcagcatcc agaactaaca gggctggatt gtataagacc ttgcttctgg     1380

gttgaactaa taagagggcg acccgaagag aacacaatct ggactagcgg gagcagcata     1440

tccttttgtg gtgtaaacag tgacactgtg ggttggtctt ggccagacgg tgctgagttg     1500

ccatttacca ttgacaagta a                                               1521


<210>  58
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N1-MPP (no his tag)

<400>  58

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro Gly Asp His Tyr Asp Asp Glu 
        35                  40                  45              


Leu Phe Ser Asp Val Gln Asp Ile Lys Thr Ala Leu Ala Lys Ile His 
    50                  55                  60                  


Glu Asp Asn Gln Lys Ile Ile Ser Lys Leu Glu Ser Leu Leu Leu Leu 
65                  70                  75                  80  


Lys Gly Glu Val Glu Ser Ile Lys Lys Gln Ile Asn Arg Gln Asn Ile 
                85                  90                  95      


Ser Ile Ser Thr Leu Glu Gly His Leu Ser Ser Ile Met Ile Ala Ile 
            100                 105                 110         


Pro Gly Leu Gly Gly Gly Ser Val Lys Leu Ala Gly Asn Ser Ser Leu 
        115                 120                 125             


Cys Pro Val Ser Gly Trp Ala Ile Tyr Ser Lys Asp Asn Ser Val Arg 
    130                 135                 140                 


Ile Gly Ser Lys Gly Asp Val Phe Val Ile Arg Glu Pro Phe Ile Ser 
145                 150                 155                 160 


Cys Ser Pro Leu Glu Cys Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu 
                165                 170                 175     


Leu Asn Asp Lys His Ser Asn Gly Thr Ile Lys Asp Arg Ser Pro Tyr 
            180                 185                 190         


Arg Thr Leu Met Ser Cys Pro Ile Gly Glu Val Pro Ser Pro Tyr Asn 
        195                 200                 205             


Ser Arg Phe Glu Ser Val Ala Trp Ser Ala Ser Ala Cys His Asp Gly 
    210                 215                 220                 


Ile Asn Trp Leu Thr Ile Gly Ile Ser Gly Pro Asp Ser Gly Ala Val 
225                 230                 235                 240 


Ala Val Leu Lys Tyr Asn Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp 
                245                 250                 255     


Arg Asn Asn Ile Leu Arg Thr Gln Glu Ser Glu Cys Ala Cys Val Asn 
            260                 265                 270         


Gly Ser Cys Phe Thr Ile Met Thr Asp Gly Pro Ser Asp Gly Gln Ala 
        275                 280                 285             


Ser Tyr Lys Ile Phe Arg Ile Glu Lys Gly Lys Ile Ile Lys Ser Val 
    290                 295                 300                 


Glu Met Lys Ala Pro Asn Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro 
305                 310                 315                 320 


Asp Ser Ser Glu Ile Thr Cys Val Cys Arg Asp Asn Trp His Gly Ser 
                325                 330                 335     


Asn Arg Pro Trp Val Ser Phe Asn Gln Asn Leu Glu Tyr Gln Met Gly 
            340                 345                 350         


Tyr Ile Cys Ser Gly Val Phe Gly Asp Asn Pro Arg Pro Asn Asp Lys 
        355                 360                 365             


Thr Gly Ser Cys Gly Pro Val Ser Ser Asn Gly Ala Asn Gly Val Lys 
    370                 375                 380                 


Gly Phe Ser Phe Lys Tyr Gly Asn Gly Val Trp Ile Gly Arg Thr Lys 
385                 390                 395                 400 


Ser Ile Ser Ser Arg Lys Gly Phe Glu Met Ile Trp Asp Pro Asn Gly 
                405                 410                 415     


Trp Thr Gly Thr Asp Asn Lys Phe Ser Ile Lys Gln Asp Ile Val Gly 
            420                 425                 430         


Ile Asn Glu Trp Ser Gly Tyr Ser Gly Ser Phe Val Gln His Pro Glu 
        435                 440                 445             


Leu Thr Gly Leu Asp Cys Ile Arg Pro Cys Phe Trp Val Glu Leu Ile 
    450                 455                 460                 


Arg Gly Arg Pro Glu Glu Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile 
465                 470                 475                 480 


Ser Phe Cys Gly Val Asn Ser Asp Thr Val Gly Trp Ser Trp Pro Asp 
                485                 490                 495     


Gly Ala Glu Leu Pro Phe Thr Ile Asp Lys 
            500                 505     


<210>  59
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  N2-MPP

<400>  59
atgctgctcg tcaaccaatc ccaccagggc ttcaacaagg aacacacttc taagatggtc       60

tccgctatcg tgctctacgt gctgctcgct gccgctgccc actcagcttt cgctgccgac      120

ccacaccacc accaccacca cggcgatcac tacgacgacg aactgttctc cgacgtgcag      180

gacatcaaga ccgctctggc taagatccac gaggacaacc agaagatcat ctccaagctg      240

gaatccctgc tgctgctgaa gggcgaagtc gagtccatca agaagcagat caaccgccag      300

aacatctcca tctccacctt ggagggtcac ctgtcctcca tcatgatcgc tatccctggc      360

ctgtctctcg tgcccagggg atcaccttct agaatatgcc ccaaaccagc agaatacaga      420

aattggtcaa aaccgcaatg tggcattaca ggatttgcac ctttctctaa ggacaattcg      480

attaggcttt ccgctggtgg ggacatctgg gtgacaagag aaccttatgt gtcatgcgat      540

cctgacaagt gttatcaatt tgcccttgga cagggaacaa caataaacaa cgtgcattca      600

aataacacag cacgtgatag gacccctcat cggactctat tgatgaatga gttgggtgtt      660

cctttccatc tggggaccaa gcaagtgtgc atagcatggt ccagctcaag ttgtcacgat      720

ggaaaagcat ggctgcatgt ttgtataacg ggggatgata aaaatgcaac tgctagtttc      780

atttacaatg ggaggcttgt agatagtgtt gtttcatggt ccaaagatat tctcaggacc      840

caggagtcag aatgcgtttg tatcaatgga acttgtacag tagtaatgac tgatggaaat      900

gctacaggaa aagctgatac taaaatatta ttcattgagg aggggaaaat cgttcatact      960

agcaaattgt caggaagtgc tcagcatgtc gaagagtgct cttgctatcc tcgataccct     1020

ggtgtcagat gtgtctgcag agacaactgg aaaggatcca accggcccat cgtagatata     1080

aacataaagg atcatagcat tgtttccagt tatgtgtgtt caggacttgt tggagacaca     1140

cccagaaaaa ccgacagctc cagcagcagc cattgcttga atcctaacaa tgaaaaaggt     1200

ggtcatggag tgaaaggctg ggcctttgat gatggaaatg acgtgtggat ggggagaaca     1260

atcaacgaga cgtcacgctt agggtatgaa accttcaaag tcgttgaagg ctggtccaac     1320

cctaagtcca aattgcagat aaataggcaa gtcatagttg acagaggtga taggtccggt     1380

tattctggta ttttctctgt tgaaggcaaa agctgcatca atcggtgctt ttatgtggag     1440

ttgattaggg gaagaaaaga ggaaactgaa gtcttgtgga cctcaaacag tattgttgtg     1500

ttttgtggca cctcaggtac atatggaaca ggctcatggc ctgatggggc ggacctcaat     1560

ctcatgcata tataa                                                      1575


<210>  60
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N2-MPP

<400>  60

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Gly 
        35                  40                  45              


Asp His Tyr Asp Asp Glu Leu Phe Ser Asp Val Gln Asp Ile Lys Thr 
    50                  55                  60                  


Ala Leu Ala Lys Ile His Glu Asp Asn Gln Lys Ile Ile Ser Lys Leu 
65                  70                  75                  80  


Glu Ser Leu Leu Leu Leu Lys Gly Glu Val Glu Ser Ile Lys Lys Gln 
                85                  90                  95      


Ile Asn Arg Gln Asn Ile Ser Ile Ser Thr Leu Glu Gly His Leu Ser 
            100                 105                 110         


Ser Ile Met Ile Ala Ile Pro Gly Leu Ser Leu Val Pro Arg Gly Ser 
        115                 120                 125             


Pro Ser Arg Ile Cys Pro Lys Pro Ala Glu Tyr Arg Asn Trp Ser Lys 
    130                 135                 140                 


Pro Gln Cys Gly Ile Thr Gly Phe Ala Pro Phe Ser Lys Asp Asn Ser 
145                 150                 155                 160 


Ile Arg Leu Ser Ala Gly Gly Asp Ile Trp Val Thr Arg Glu Pro Tyr 
                165                 170                 175     


Val Ser Cys Asp Pro Asp Lys Cys Tyr Gln Phe Ala Leu Gly Gln Gly 
            180                 185                 190         


Thr Thr Ile Asn Asn Val His Ser Asn Asn Thr Ala Arg Asp Arg Thr 
        195                 200                 205             


Pro His Arg Thr Leu Leu Met Asn Glu Leu Gly Val Pro Phe His Leu 
    210                 215                 220                 


Gly Thr Lys Gln Val Cys Ile Ala Trp Ser Ser Ser Ser Cys His Asp 
225                 230                 235                 240 


Gly Lys Ala Trp Leu His Val Cys Ile Thr Gly Asp Asp Lys Asn Ala 
                245                 250                 255     


Thr Ala Ser Phe Ile Tyr Asn Gly Arg Leu Val Asp Ser Val Val Ser 
            260                 265                 270         


Trp Ser Lys Asp Ile Leu Arg Thr Gln Glu Ser Glu Cys Val Cys Ile 
        275                 280                 285             


Asn Gly Thr Cys Thr Val Val Met Thr Asp Gly Asn Ala Thr Gly Lys 
    290                 295                 300                 


Ala Asp Thr Lys Ile Leu Phe Ile Glu Glu Gly Lys Ile Val His Thr 
305                 310                 315                 320 


Ser Lys Leu Ser Gly Ser Ala Gln His Val Glu Glu Cys Ser Cys Tyr 
                325                 330                 335     


Pro Arg Tyr Pro Gly Val Arg Cys Val Cys Arg Asp Asn Trp Lys Gly 
            340                 345                 350         


Ser Asn Arg Pro Ile Val Asp Ile Asn Ile Lys Asp His Ser Ile Val 
        355                 360                 365             


Ser Ser Tyr Val Cys Ser Gly Leu Val Gly Asp Thr Pro Arg Lys Thr 
    370                 375                 380                 


Asp Ser Ser Ser Ser Ser His Cys Leu Asn Pro Asn Asn Glu Lys Gly 
385                 390                 395                 400 


Gly His Gly Val Lys Gly Trp Ala Phe Asp Asp Gly Asn Asp Val Trp 
                405                 410                 415     


Met Gly Arg Thr Ile Asn Glu Thr Ser Arg Leu Gly Tyr Glu Thr Phe 
            420                 425                 430         


Lys Val Val Glu Gly Trp Ser Asn Pro Lys Ser Lys Leu Gln Ile Asn 
        435                 440                 445             


Arg Gln Val Ile Val Asp Arg Gly Asp Arg Ser Gly Tyr Ser Gly Ile 
    450                 455                 460                 


Phe Ser Val Glu Gly Lys Ser Cys Ile Asn Arg Cys Phe Tyr Val Glu 
465                 470                 475                 480 


Leu Ile Arg Gly Arg Lys Glu Glu Thr Glu Val Leu Trp Thr Ser Asn 
                485                 490                 495     


Ser Ile Val Val Phe Cys Gly Thr Ser Gly Thr Tyr Gly Thr Gly Ser 
            500                 505                 510         


Trp Pro Asp Gly Ala Asp Leu Asn Leu Met His Ile 
        515                 520                 


<210>  61
<211>  1578
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-MPP

<400>  61
atgctgctcg tcaaccaatc ccaccagggc ttcaacaagg aacacacttc taagatggtc       60

tccgctatcg tgctctacgt gctgctcgct gccgctgccc actcagcttt cgctgccgac      120

ccacaccacc accaccacca cggcgatcac tacgacgacg aactgttctc cgacgtgcag      180

gacatcaaga ccgctctggc taagatccac gaggacaacc agaagatcat ctccaagctg      240

gaatccctgc tgctgctgaa gggcgaagtc gagtccatca agaagcagat caaccgccag      300

aacatctcca tctccacctt ggagggtcac ctgtcctcca tcatgatcgc tatccctggc      360

ctgtctctcg tgcccagggg atcaccttct agacttcttc tcccagaacc ggagtggaca      420

tacccgcgtt tatcttgccc gggctcaacc tttcagaaag cactcctaat tagccctcat      480

agattcggag aaaccaaagg aaactcagct cccttgataa taagggaacc ttttgttgct      540

tgtggaccaa atgaatgcaa acactttgct ttaacccatt atgcagccca accaggggga      600

tactacaatg gaacaagagg agacagaaac aagctgaggc atctaatttc agtcaaattg      660

ggcaaaatcc caacagtaga gaactccatt ttccacatgg cagcatggag cgggtccgcg      720

tgccatgatg gtaaggaatg gacatatatc ggagttgatg gccctgacaa taatgcattg      780

ctcaaagtaa aatatggaga agcatatact gacacatacc attcctatgc aaacaacatc      840

ctaagaacac aagaaagtgc ctgcaattgc atcgggggaa attgttatct aatgataact      900

gatggctcag cttcaggtgt tagtgaatgc agatttctta agattcgaga gggccgaata      960

ataaaagaaa tatttccaac aggaagagta aaacacactg aggaatgcac atgcggattt     1020

gccagcaata aaaccataga atgtgcctgt agagacaaca ggtacacagc aaaaagacct     1080

tttgtcaaat taaacgtgga gactgataca gcagaaataa ggttgatgtg cacagatacc     1140

tatttggaca cccccagacc aaatgatgga agcataacag gcccttgtga atctgatggg     1200

gacaaaggga gtggaggcat caagggagga tttgttcatc aaagaatgaa atccaagatt     1260

ggaaggtggt actctcgaac gatgtctcaa actgaaagga tggggatggg actgtatgtc     1320

aagtatggtg gagacccatg ggctgacagt gatgccctag cttttagtgg agtaatggtt     1380

tcaatgaaag aacctggttg gtattccttt ggcttcgaaa taaaagataa gaaatgcgat     1440

gtcccctgta ttgggataga gatggtacat gatggtggaa aagagacttg gcactcagca     1500

gcaacagcca tttactgttt aatgggctca ggacagctgc tgtgggacac tgtcacaggt     1560

gttgacatgg ctctgtaa                                                   1578


<210>  62
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-MPP

<400>  62

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala Ala Asp Pro His His His His His His Gly 
        35                  40                  45              


Asp His Tyr Asp Asp Glu Leu Phe Ser Asp Val Gln Asp Ile Lys Thr 
    50                  55                  60                  


Ala Leu Ala Lys Ile His Glu Asp Asn Gln Lys Ile Ile Ser Lys Leu 
65                  70                  75                  80  


Glu Ser Leu Leu Leu Leu Lys Gly Glu Val Glu Ser Ile Lys Lys Gln 
                85                  90                  95      


Ile Asn Arg Gln Asn Ile Ser Ile Ser Thr Leu Glu Gly His Leu Ser 
            100                 105                 110         


Ser Ile Met Ile Ala Ile Pro Gly Leu Ser Leu Val Pro Arg Gly Ser 
        115                 120                 125             


Pro Ser Arg Leu Leu Leu Pro Glu Pro Glu Trp Thr Tyr Pro Arg Leu 
    130                 135                 140                 


Ser Cys Pro Gly Ser Thr Phe Gln Lys Ala Leu Leu Ile Ser Pro His 
145                 150                 155                 160 


Arg Phe Gly Glu Thr Lys Gly Asn Ser Ala Pro Leu Ile Ile Arg Glu 
                165                 170                 175     


Pro Phe Val Ala Cys Gly Pro Asn Glu Cys Lys His Phe Ala Leu Thr 
            180                 185                 190         


His Tyr Ala Ala Gln Pro Gly Gly Tyr Tyr Asn Gly Thr Arg Gly Asp 
        195                 200                 205             


Arg Asn Lys Leu Arg His Leu Ile Ser Val Lys Leu Gly Lys Ile Pro 
    210                 215                 220                 


Thr Val Glu Asn Ser Ile Phe His Met Ala Ala Trp Ser Gly Ser Ala 
225                 230                 235                 240 


Cys His Asp Gly Lys Glu Trp Thr Tyr Ile Gly Val Asp Gly Pro Asp 
                245                 250                 255     


Asn Asn Ala Leu Leu Lys Val Lys Tyr Gly Glu Ala Tyr Thr Asp Thr 
            260                 265                 270         


Tyr His Ser Tyr Ala Asn Asn Ile Leu Arg Thr Gln Glu Ser Ala Cys 
        275                 280                 285             


Asn Cys Ile Gly Gly Asn Cys Tyr Leu Met Ile Thr Asp Gly Ser Ala 
    290                 295                 300                 


Ser Gly Val Ser Glu Cys Arg Phe Leu Lys Ile Arg Glu Gly Arg Ile 
305                 310                 315                 320 


Ile Lys Glu Ile Phe Pro Thr Gly Arg Val Lys His Thr Glu Glu Cys 
                325                 330                 335     


Thr Cys Gly Phe Ala Ser Asn Lys Thr Ile Glu Cys Ala Cys Arg Asp 
            340                 345                 350         


Asn Arg Tyr Thr Ala Lys Arg Pro Phe Val Lys Leu Asn Val Glu Thr 
        355                 360                 365             


Asp Thr Ala Glu Ile Arg Leu Met Cys Thr Asp Thr Tyr Leu Asp Thr 
    370                 375                 380                 


Pro Arg Pro Asn Asp Gly Ser Ile Thr Gly Pro Cys Glu Ser Asp Gly 
385                 390                 395                 400 


Asp Lys Gly Ser Gly Gly Ile Lys Gly Gly Phe Val His Gln Arg Met 
                405                 410                 415     


Lys Ser Lys Ile Gly Arg Trp Tyr Ser Arg Thr Met Ser Gln Thr Glu 
            420                 425                 430         


Arg Met Gly Met Gly Leu Tyr Val Lys Tyr Gly Gly Asp Pro Trp Ala 
        435                 440                 445             


Asp Ser Asp Ala Leu Ala Phe Ser Gly Val Met Val Ser Met Lys Glu 
    450                 455                 460                 


Pro Gly Trp Tyr Ser Phe Gly Phe Glu Ile Lys Asp Lys Lys Cys Asp 
465                 470                 475                 480 


Val Pro Cys Ile Gly Ile Glu Met Val His Asp Gly Gly Lys Glu Thr 
                485                 490                 495     


Trp His Ser Ala Ala Thr Ala Ile Tyr Cys Leu Met Gly Ser Gly Gln 
            500                 505                 510         


Leu Leu Trp Asp Thr Val Thr Gly Val Asp Met Ala Leu 
        515                 520                 525 


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage site

<400>  63

Ser Leu Val Pro Arg Gly Ser Pro Ser Arg 
1               5                   10  


<210>  64
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Globular head domain of NA of influenza virus A/Kansas/14/2017

<400>  64

Ile Cys Pro Lys Pro Ala Glu Tyr Arg Asn Trp Ser Lys Pro Gln Cys 
1               5                   10                  15      


Gly Ile Thr Gly Phe Ala Pro Phe Ser Lys Asp Asn Ser Ile Arg Leu 
            20                  25                  30          


Ser Ala Gly Gly Asp Ile Trp Val Thr Arg Glu Pro Tyr Val Ser Cys 
        35                  40                  45              


Asp Pro Asp Lys Cys Tyr Gln Phe Ala Leu Gly Gln Gly Thr Thr Ile 
    50                  55                  60                  


Asn Asn Val His Ser Asn Asn Thr Ala Arg Asp Arg Thr Pro His Arg 
65                  70                  75                  80  


Thr Leu Leu Met Asn Glu Leu Gly Val Pro Phe His Leu Gly Thr Lys 
                85                  90                  95      


Gln Val Cys Ile Ala Trp Ser Ser Ser Ser Cys His Asp Gly Lys Ala 
            100                 105                 110         


Trp Leu His Val Cys Ile Thr Gly Asp Asp Lys Asn Ala Thr Ala Ser 
        115                 120                 125             


Phe Ile Tyr Asn Gly Arg Leu Val Asp Ser Val Val Ser Trp Ser Lys 
    130                 135                 140                 


Asp Ile Leu Arg Thr Gln Glu Ser Glu Cys Val Cys Ile Asn Gly Thr 
145                 150                 155                 160 


Cys Thr Val Val Met Thr Asp Gly Asn Ala Thr Gly Lys Ala Asp Thr 
                165                 170                 175     


Lys Ile Leu Phe Ile Glu Glu Gly Lys Ile Val His Thr Ser Lys Leu 
            180                 185                 190         


Ser Gly Ser Ala Gln His Val Glu Glu Cys Ser Cys Tyr Pro Arg Tyr 
        195                 200                 205             


Pro Gly Val Arg Cys Val Cys Arg Asp Asn Trp Lys Gly Ser Asn Arg 
    210                 215                 220                 


Pro Ile Val Asp Ile Asn Ile Lys Asp His Ser Ile Val Ser Ser Tyr 
225                 230                 235                 240 


Val Cys Ser Gly Leu Val Gly Asp Thr Pro Arg Lys Thr Asp Ser Ser 
                245                 250                 255     


Ser Ser Ser His Cys Leu Asn Pro Asn Asn Glu Lys Gly Gly His Gly 
            260                 265                 270         


Val Lys Gly Trp Ala Phe Asp Asp Gly Asn Asp Val Trp Met Gly Arg 
        275                 280                 285             


Thr Ile Asn Glu Thr Ser Arg Leu Gly Tyr Glu Thr Phe Lys Val Val 
    290                 295                 300                 


Glu Gly Trp Ser Asn Pro Lys Ser Lys Leu Gln Ile Asn Arg Gln Val 
305                 310                 315                 320 


Ile Val Asp Arg Gly Asp Arg Ser Gly Tyr Ser Gly Ile Phe Ser Val 
                325                 330                 335     


Glu Gly Lys Ser Cys Ile Asn Arg Cys Phe Tyr Val Glu Leu Ile Arg 
            340                 345                 350         


Gly Arg Lys Glu Glu Thr Glu Val Leu Trp Thr Ser Asn Ser Ile Val 
        355                 360                 365             


Val Phe Cys Gly Thr Ser Gly Thr Tyr Gly Thr Gly Ser Trp Pro Asp 
    370                 375                 380                 


Gly Ala Asp Leu Asn Leu Met His Ile 
385                 390             


<210>  65
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Globular head domain of NA of influenza virus B/Colorado/06/2017

<400>  65

Leu Leu Leu Pro Glu Pro Glu Trp Thr Tyr Pro Arg Leu Ser Cys Pro 
1               5                   10                  15      


Gly Ser Thr Phe Gln Lys Ala Leu Leu Ile Ser Pro His Arg Phe Gly 
            20                  25                  30          


Glu Thr Lys Gly Asn Ser Ala Pro Leu Ile Ile Arg Glu Pro Phe Val 
        35                  40                  45              


Ala Cys Gly Pro Asn Glu Cys Lys His Phe Ala Leu Thr His Tyr Ala 
    50                  55                  60                  


Ala Gln Pro Gly Gly Tyr Tyr Asn Gly Thr Arg Gly Asp Arg Asn Lys 
65                  70                  75                  80  


Leu Arg His Leu Ile Ser Val Lys Leu Gly Lys Ile Pro Thr Val Glu 
                85                  90                  95      


Asn Ser Ile Phe His Met Ala Ala Trp Ser Gly Ser Ala Cys His Asp 
            100                 105                 110         


Gly Lys Glu Trp Thr Tyr Ile Gly Val Asp Gly Pro Asp Asn Asn Ala 
        115                 120                 125             


Leu Leu Lys Val Lys Tyr Gly Glu Ala Tyr Thr Asp Thr Tyr His Ser 
    130                 135                 140                 


Tyr Ala Asn Asn Ile Leu Arg Thr Gln Glu Ser Ala Cys Asn Cys Ile 
145                 150                 155                 160 


Gly Gly Asn Cys Tyr Leu Met Ile Thr Asp Gly Ser Ala Ser Gly Val 
                165                 170                 175     


Ser Glu Cys Arg Phe Leu Lys Ile Arg Glu Gly Arg Ile Ile Lys Glu 
            180                 185                 190         


Ile Phe Pro Thr Gly Arg Val Lys His Thr Glu Glu Cys Thr Cys Gly 
        195                 200                 205             


Phe Ala Ser Asn Lys Thr Ile Glu Cys Ala Cys Arg Asp Asn Arg Tyr 
    210                 215                 220                 


Thr Ala Lys Arg Pro Phe Val Lys Leu Asn Val Glu Thr Asp Thr Ala 
225                 230                 235                 240 


Glu Ile Arg Leu Met Cys Thr Asp Thr Tyr Leu Asp Thr Pro Arg Pro 
                245                 250                 255     


Asn Asp Gly Ser Ile Thr Gly Pro Cys Glu Ser Asp Gly Asp Lys Gly 
            260                 265                 270         


Ser Gly Gly Ile Lys Gly Gly Phe Val His Gln Arg Met Lys Ser Lys 
        275                 280                 285             


Ile Gly Arg Trp Tyr Ser Arg Thr Met Ser Gln Thr Glu Arg Met Gly 
    290                 295                 300                 


Met Gly Leu Tyr Val Lys Tyr Gly Gly Asp Pro Trp Ala Asp Ser Asp 
305                 310                 315                 320 


Ala Leu Ala Phe Ser Gly Val Met Val Ser Met Lys Glu Pro Gly Trp 
                325                 330                 335     


Tyr Ser Phe Gly Phe Glu Ile Lys Asp Lys Lys Cys Asp Val Pro Cys 
            340                 345                 350         


Ile Gly Ile Glu Met Val His Asp Gly Gly Lys Glu Thr Trp His Ser 
        355                 360                 365             


Ala Ala Thr Ala Ile Tyr Cys Leu Met Gly Ser Gly Gln Leu Leu Trp 
    370                 375                 380                 


Asp Thr Val Thr Gly Val Asp Met Ala Leu 
385                 390                 


<210>  66
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Globular head domain of NA of influenza virus A/Michigan/45/15

<400>  66

Ser Val Lys Leu Ala Gly Asn Ser Ser Leu Cys Pro Val Ser Gly Trp 
1               5                   10                  15      


Ala Ile Tyr Ser Lys Asp Asn Ser Val Arg Ile Gly Ser Lys Gly Asp 
            20                  25                  30          


Val Phe Val Ile Arg Glu Pro Phe Ile Ser Cys Ser Pro Leu Glu Cys 
        35                  40                  45              


Arg Thr Phe Phe Leu Thr Gln Gly Ala Leu Leu Asn Asp Lys His Ser 
    50                  55                  60                  


Asn Gly Thr Ile Lys Asp Arg Ser Pro Tyr Arg Thr Leu Met Ser Cys 
65                  70                  75                  80  


Pro Ile Gly Glu Val Pro Ser Pro Tyr Asn Ser Arg Phe Glu Ser Val 
                85                  90                  95      


Ala Trp Ser Ala Ser Ala Cys His Asp Gly Ile Asn Trp Leu Thr Ile 
            100                 105                 110         


Gly Ile Ser Gly Pro Asp Ser Gly Ala Val Ala Val Leu Lys Tyr Asn 
        115                 120                 125             


Gly Ile Ile Thr Asp Thr Ile Lys Ser Trp Arg Asn Asn Ile Leu Arg 
    130                 135                 140                 


Thr Gln Glu Ser Glu Cys Ala Cys Val Asn Gly Ser Cys Phe Thr Ile 
145                 150                 155                 160 


Met Thr Asp Gly Pro Ser Asp Gly Gln Ala Ser Tyr Lys Ile Phe Arg 
                165                 170                 175     


Ile Glu Lys Gly Lys Ile Ile Lys Ser Val Glu Met Lys Ala Pro Asn 
            180                 185                 190         


Tyr His Tyr Glu Glu Cys Ser Cys Tyr Pro Asp Ser Ser Glu Ile Thr 
        195                 200                 205             


Cys Val Cys Arg Asp Asn Trp His Gly Ser Asn Arg Pro Trp Val Ser 
    210                 215                 220                 


Phe Asn Gln Asn Leu Glu Tyr Gln Met Gly Tyr Ile Cys Ser Gly Val 
225                 230                 235                 240 


Phe Gly Asp Asn Pro Arg Pro Asn Asp Lys Thr Gly Ser Cys Gly Pro 
                245                 250                 255     


Val Ser Ser Asn Gly Ala Asn Gly Val Lys Gly Phe Ser Phe Lys Tyr 
            260                 265                 270         


Gly Asn Gly Val Trp Ile Gly Arg Thr Lys Ser Ile Ser Ser Arg Lys 
        275                 280                 285             


Gly Phe Glu Met Ile Trp Asp Pro Asn Gly Trp Thr Gly Thr Asp Asn 
    290                 295                 300                 


Lys Phe Ser Ile Lys Gln Asp Ile Val Gly Ile Asn Glu Trp Ser Gly 
305                 310                 315                 320 


Tyr Ser Gly Ser Phe Val Gln His Pro Glu Leu Thr Gly Leu Asp Cys 
                325                 330                 335     


Ile Arg Pro Cys Phe Trp Val Glu Leu Ile Arg Gly Arg Pro Glu Glu 
            340                 345                 350         


Asn Thr Ile Trp Thr Ser Gly Ser Ser Ile Ser Phe Cys Gly Val Asn 
        355                 360                 365             


Ser Asp Thr Val Gly Trp Ser Trp Pro Asp Gly Ala Glu Leu Pro Phe 
    370                 375                 380                 


Thr Ile Asp Lys 
385             


