                               SEQUENCE LISTING

<110> DANA-FARBER CANCER INSTITUTE, INC.
 
<120> COMPOSITIONS COMPRISING MODIFIED SMARCB1 AND USES THEREOF

<130> DFS-27825

<140> PCT/US2020/056574
<141> 2020-10-21

<150> 62/926,139
<151> 2019-10-25

<160> 54    

<170> PatentIn version 3.5

<210> 1
<211> 1749
<212> DNA
<213> Homo sapiens

<400> 1
tttgtttgag cggcggcgcg cgcgtcagcg tcaacgccag cgcctgcgca ctgagggcgg       60

cctggtcgtc gtctgcggcg gcggcggcgg ctgaggagcc cggctgaggc gccagtaccc      120

ggcccggtcc gcatttcgcc ttccggcttc ggtttccctc ggcccagcac gccccggccc      180

cgccccagcc ctcctgatcc ctcgcagccc ggctccggcc gcccgcctct gccgccgcaa      240

tgatgatgat ggcgctgagc aagaccttcg ggcagaagcc cgtgaagttc cagctggagg      300

acgacggcga gttctacatg atcggctccg aggtgggaaa ctacctccgt atgttccgag      360

gttctctgta caagagatac ccctcactct ggaggcgact agccactgtg gaagagagga      420

agaaaatagt tgcatcgtca catggtaaaa aaacaaaacc taacactaag gatcacggat      480

acacgactct agccaccagt gtgaccctgt taaaagcctc ggaagtggaa gagattctgg      540

atggcaacga tgagaagtac aaggctgtgt ccatcagcac agagcccccc acctacctca      600

gggaacagaa ggccaagagg aacagccagt gggtacccac cctgcccaac agctcccacc      660

acttagatgc cgtgccatgc tccacaacca tcaacaggaa ccgcatgggc cgagacaaga      720

agagaacctt ccccctttgc tttgatgacc atgacccagc tgtgatccat gagaacgcat      780

ctcagcccga ggtgctggtc cccatccggc tggacatgga gatcgatggg cagaagctgc      840

gagacgcctt cacctggaac atgaatgaga agttgatgac gcctgagatg ttttcagaaa      900

tcctctgtga cgatctggat ttgaacccgc tgacgtttgt gccagccatc gcctctgcca      960

tcagacagca gatcgagtcc taccccacgg acagcatcct ggaggaccag tcagaccagc     1020

gcgtcatcat caagctgaac atccatgtgg gaaacatttc cctggtggac cagtttgagt     1080

gggacatgtc agagaaggag aactcaccag agaagtttgc cctgaagctg tgctcggagc     1140

tggggttggg cggggagttt gtcaccacca tcgcatacag catccgggga cagctgagct     1200

ggcatcagaa gacctacgcc ttcagcgaga accctctgcc cacagtggag attgccatcc     1260

ggaacacggg cgatgcggac cagtggtgcc cactgctgga gactctgaca gacgctgaga     1320

tggagaagaa gatccgcgac caggacagga acacgaggcg gatgaggcgt cttgccaaca     1380

cggccccggc ctggtaacca gcccatcagc acacggctcc cacggagcat ctcagaagat     1440

tgggccgcct ctcctccatc ttctggcaag gacagaggcg aggggacagc ccagcgccat     1500

cctgaggatc gggtgggggt ggagtggggg cttccaggtg gcccttcccg gcacacattc     1560

catttgttga gccccagtcc tgccccccac cccaccctcc ctacccctcc ccagtctctg     1620

gggtcaggaa gaaaccttat tttaggttgt gttttgtttt tgtataggag ccccaggcag     1680

ggctagtaac agtttttaaa taaaaggcaa caggtcatgt tcaatttctt caacaaaaaa     1740

aaaaaaaaa                                                             1749


<210> 2
<211> 385
<212> PRT
<213> Homo sapiens

<400> 2
Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Gly Lys Lys Thr Lys Pro Asn Thr Lys Asp His Gly 
65                  70                  75                  80  


Tyr Thr Thr Leu Ala Thr Ser Val Thr Leu Leu Lys Ala Ser Glu Val 
                85                  90                  95      


Glu Glu Ile Leu Asp Gly Asn Asp Glu Lys Tyr Lys Ala Val Ser Ile 
            100                 105                 110         


Ser Thr Glu Pro Pro Thr Tyr Leu Arg Glu Gln Lys Ala Lys Arg Asn 
        115                 120                 125             


Ser Gln Trp Val Pro Thr Leu Pro Asn Ser Ser His His Leu Asp Ala 
    130                 135                 140                 


Val Pro Cys Ser Thr Thr Ile Asn Arg Asn Arg Met Gly Arg Asp Lys 
145                 150                 155                 160 


Lys Arg Thr Phe Pro Leu Cys Phe Asp Asp His Asp Pro Ala Val Ile 
                165                 170                 175     


His Glu Asn Ala Ser Gln Pro Glu Val Leu Val Pro Ile Arg Leu Asp 
            180                 185                 190         


Met Glu Ile Asp Gly Gln Lys Leu Arg Asp Ala Phe Thr Trp Asn Met 
        195                 200                 205             


Asn Glu Lys Leu Met Thr Pro Glu Met Phe Ser Glu Ile Leu Cys Asp 
    210                 215                 220                 


Asp Leu Asp Leu Asn Pro Leu Thr Phe Val Pro Ala Ile Ala Ser Ala 
225                 230                 235                 240 


Ile Arg Gln Gln Ile Glu Ser Tyr Pro Thr Asp Ser Ile Leu Glu Asp 
                245                 250                 255     


Gln Ser Asp Gln Arg Val Ile Ile Lys Leu Asn Ile His Val Gly Asn 
            260                 265                 270         


Ile Ser Leu Val Asp Gln Phe Glu Trp Asp Met Ser Glu Lys Glu Asn 
        275                 280                 285             


Ser Pro Glu Lys Phe Ala Leu Lys Leu Cys Ser Glu Leu Gly Leu Gly 
    290                 295                 300                 


Gly Glu Phe Val Thr Thr Ile Ala Tyr Ser Ile Arg Gly Gln Leu Ser 
305                 310                 315                 320 


Trp His Gln Lys Thr Tyr Ala Phe Ser Glu Asn Pro Leu Pro Thr Val 
                325                 330                 335     


Glu Ile Ala Ile Arg Asn Thr Gly Asp Ala Asp Gln Trp Cys Pro Leu 
            340                 345                 350         


Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg Asp Gln 
        355                 360                 365             


Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala Pro Ala 
    370                 375                 380                 


Trp 
385 


<210> 3
<211> 1722
<212> DNA
<213> Homo sapiens

<400> 3
tttgtttgag cggcggcgcg cgcgtcagcg tcaacgccag cgcctgcgca ctgagggcgg       60

cctggtcgtc gtctgcggcg gcggcggcgg ctgaggagcc cggctgaggc gccagtaccc      120

ggcccggtcc gcatttcgcc ttccggcttc ggtttccctc ggcccagcac gccccggccc      180

cgccccagcc ctcctgatcc ctcgcagccc ggctccggcc gcccgcctct gccgccgcaa      240

tgatgatgat ggcgctgagc aagaccttcg ggcagaagcc cgtgaagttc cagctggagg      300

acgacggcga gttctacatg atcggctccg aggtgggaaa ctacctccgt atgttccgag      360

gttctctgta caagagatac ccctcactct ggaggcgact agccactgtg gaagagagga      420

agaaaatagt tgcatcgtca catgatcacg gatacacgac tctagccacc agtgtgaccc      480

tgttaaaagc ctcggaagtg gaagagattc tggatggcaa cgatgagaag tacaaggctg      540

tgtccatcag cacagagccc cccacctacc tcagggaaca gaaggccaag aggaacagcc      600

agtgggtacc caccctgccc aacagctccc accacttaga tgccgtgcca tgctccacaa      660

ccatcaacag gaaccgcatg ggccgagaca agaagagaac cttccccctt tgctttgatg      720

accatgaccc agctgtgatc catgagaacg catctcagcc cgaggtgctg gtccccatcc      780

ggctggacat ggagatcgat gggcagaagc tgcgagacgc cttcacctgg aacatgaatg      840

agaagttgat gacgcctgag atgttttcag aaatcctctg tgacgatctg gatttgaacc      900

cgctgacgtt tgtgccagcc atcgcctctg ccatcagaca gcagatcgag tcctacccca      960

cggacagcat cctggaggac cagtcagacc agcgcgtcat catcaagctg aacatccatg     1020

tgggaaacat ttccctggtg gaccagtttg agtgggacat gtcagagaag gagaactcac     1080

cagagaagtt tgccctgaag ctgtgctcgg agctggggtt gggcggggag tttgtcacca     1140

ccatcgcata cagcatccgg ggacagctga gctggcatca gaagacctac gccttcagcg     1200

agaaccctct gcccacagtg gagattgcca tccggaacac gggcgatgcg gaccagtggt     1260

gcccactgct ggagactctg acagacgctg agatggagaa gaagatccgc gaccaggaca     1320

ggaacacgag gcggatgagg cgtcttgcca acacggcccc ggcctggtaa ccagcccatc     1380

agcacacggc tcccacggag catctcagaa gattgggccg cctctcctcc atcttctggc     1440

aaggacagag gcgaggggac agcccagcgc catcctgagg atcgggtggg ggtggagtgg     1500

gggcttccag gtggcccttc ccggcacaca ttccatttgt tgagccccag tcctgccccc     1560

caccccaccc tccctacccc tccccagtct ctggggtcag gaagaaacct tattttaggt     1620

tgtgttttgt ttttgtatag gagccccagg cagggctagt aacagttttt aaataaaagg     1680

caacaggtca tgttcaattt cttcaacaaa aaaaaaaaaa aa                        1722


<210> 4
<211> 376
<212> PRT
<213> Homo sapiens

<400> 4
Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Asp His Gly Tyr Thr Thr Leu Ala Thr Ser Val Thr 
65                  70                  75                  80  


Leu Leu Lys Ala Ser Glu Val Glu Glu Ile Leu Asp Gly Asn Asp Glu 
                85                  90                  95      


Lys Tyr Lys Ala Val Ser Ile Ser Thr Glu Pro Pro Thr Tyr Leu Arg 
            100                 105                 110         


Glu Gln Lys Ala Lys Arg Asn Ser Gln Trp Val Pro Thr Leu Pro Asn 
        115                 120                 125             


Ser Ser His His Leu Asp Ala Val Pro Cys Ser Thr Thr Ile Asn Arg 
    130                 135                 140                 


Asn Arg Met Gly Arg Asp Lys Lys Arg Thr Phe Pro Leu Cys Phe Asp 
145                 150                 155                 160 


Asp His Asp Pro Ala Val Ile His Glu Asn Ala Ser Gln Pro Glu Val 
                165                 170                 175     


Leu Val Pro Ile Arg Leu Asp Met Glu Ile Asp Gly Gln Lys Leu Arg 
            180                 185                 190         


Asp Ala Phe Thr Trp Asn Met Asn Glu Lys Leu Met Thr Pro Glu Met 
        195                 200                 205             


Phe Ser Glu Ile Leu Cys Asp Asp Leu Asp Leu Asn Pro Leu Thr Phe 
    210                 215                 220                 


Val Pro Ala Ile Ala Ser Ala Ile Arg Gln Gln Ile Glu Ser Tyr Pro 
225                 230                 235                 240 


Thr Asp Ser Ile Leu Glu Asp Gln Ser Asp Gln Arg Val Ile Ile Lys 
                245                 250                 255     


Leu Asn Ile His Val Gly Asn Ile Ser Leu Val Asp Gln Phe Glu Trp 
            260                 265                 270         


Asp Met Ser Glu Lys Glu Asn Ser Pro Glu Lys Phe Ala Leu Lys Leu 
        275                 280                 285             


Cys Ser Glu Leu Gly Leu Gly Gly Glu Phe Val Thr Thr Ile Ala Tyr 
    290                 295                 300                 


Ser Ile Arg Gly Gln Leu Ser Trp His Gln Lys Thr Tyr Ala Phe Ser 
305                 310                 315                 320 


Glu Asn Pro Leu Pro Thr Val Glu Ile Ala Ile Arg Asn Thr Gly Asp 
                325                 330                 335     


Ala Asp Gln Trp Cys Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met 
            340                 345                 350         


Glu Lys Lys Ile Arg Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg 
        355                 360                 365             


Leu Ala Asn Thr Ala Pro Ala Trp 
    370                 375     


<210> 5
<211> 1776
<212> DNA
<213> Homo sapiens

<400> 5
tttgtttgag cggcggcgcg cgcgtcagcg tcaacgccag cgcctgcgca ctgagggcgg       60

cctggtcgtc gtctgcggcg gcggcggcgg ctgaggagcc cggctgaggc gccagtaccc      120

ggcccggtcc gcatttcgcc ttccggcttc ggtttccctc ggcccagcac gccccggccc      180

cgccccagcc ctcctgatcc ctcgcagccc ggctccggcc gcccgcctct gccgccgcaa      240

tgatgatgat ggcgctgagc aagaccttcg ggcagaagcc cgtgaagttc cagctggagg      300

acgacggcga gttctacatg atcggctccg aggtgggaaa ctacctccgt atgttccgag      360

gttctctgta caagagatac ccctcactct ggaggcgact agccactgtg gaagagagga      420

agaaaatagt tgcatcgtca catgatcacg gatacacgac tctagccacc agtgtgaccc      480

tgttaaaagc ctcggaagtg gaagagattc tggatggcaa cgatgagaag tacaaggctg      540

tgtccatcag cacagagccc cccacctacc tcagggaaca gaaggccaag aggaacagcc      600

agtgggtacc caccctgccc aacagctccc accacttaga tgccgtgcca tgctccacaa      660

ccatcaacag gaaccgcatg ggccgagaca agaagagaac cttccccctt tggtgtggat      720

gcatcgctgc actcaccctc cgtgctgatt ccgccttagt tctccacttt gatgaccatg      780

acccagctgt gatccatgag aacgcatctc agcccgaggt gctggtcccc atccggctgg      840

acatggagat cgatgggcag aagctgcgag acgccttcac ctggaacatg aatgagaagt      900

tgatgacgcc tgagatgttt tcagaaatcc tctgtgacga tctggatttg aacccgctga      960

cgtttgtgcc agccatcgcc tctgccatca gacagcagat cgagtcctac cccacggaca     1020

gcatcctgga ggaccagtca gaccagcgcg tcatcatcaa gctgaacatc catgtgggaa     1080

acatttccct ggtggaccag tttgagtggg acatgtcaga gaaggagaac tcaccagaga     1140

agtttgccct gaagctgtgc tcggagctgg ggttgggcgg ggagtttgtc accaccatcg     1200

catacagcat ccggggacag ctgagctggc atcagaagac ctacgccttc agcgagaacc     1260

ctctgcccac agtggagatt gccatccgga acacgggcga tgcggaccag tggtgcccac     1320

tgctggagac tctgacagac gctgagatgg agaagaagat ccgcgaccag gacaggaaca     1380

cgaggcggat gaggcgtctt gccaacacgg ccccggcctg gtaaccagcc catcagcaca     1440

cggctcccac ggagcatctc agaagattgg gccgcctctc ctccatcttc tggcaaggac     1500

agaggcgagg ggacagccca gcgccatcct gaggatcggg tgggggtgga gtgggggctt     1560

ccaggtggcc cttcccggca cacattccat ttgttgagcc ccagtcctgc cccccacccc     1620

accctcccta cccctcccca gtctctgggg tcaggaagaa accttatttt aggttgtgtt     1680

ttgtttttgt ataggagccc caggcagggc tagtaacagt ttttaaataa aaggcaacag     1740

gtcatgttca atttcttcaa caaaaaaaaa aaaaaa                               1776


<210> 6
<211> 394
<212> PRT
<213> Homo sapiens

<400> 6
Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Asp His Gly Tyr Thr Thr Leu Ala Thr Ser Val Thr 
65                  70                  75                  80  


Leu Leu Lys Ala Ser Glu Val Glu Glu Ile Leu Asp Gly Asn Asp Glu 
                85                  90                  95      


Lys Tyr Lys Ala Val Ser Ile Ser Thr Glu Pro Pro Thr Tyr Leu Arg 
            100                 105                 110         


Glu Gln Lys Ala Lys Arg Asn Ser Gln Trp Val Pro Thr Leu Pro Asn 
        115                 120                 125             


Ser Ser His His Leu Asp Ala Val Pro Cys Ser Thr Thr Ile Asn Arg 
    130                 135                 140                 


Asn Arg Met Gly Arg Asp Lys Lys Arg Thr Phe Pro Leu Trp Cys Gly 
145                 150                 155                 160 


Cys Ile Ala Ala Leu Thr Leu Arg Ala Asp Ser Ala Leu Val Leu His 
                165                 170                 175     


Phe Asp Asp His Asp Pro Ala Val Ile His Glu Asn Ala Ser Gln Pro 
            180                 185                 190         


Glu Val Leu Val Pro Ile Arg Leu Asp Met Glu Ile Asp Gly Gln Lys 
        195                 200                 205             


Leu Arg Asp Ala Phe Thr Trp Asn Met Asn Glu Lys Leu Met Thr Pro 
    210                 215                 220                 


Glu Met Phe Ser Glu Ile Leu Cys Asp Asp Leu Asp Leu Asn Pro Leu 
225                 230                 235                 240 


Thr Phe Val Pro Ala Ile Ala Ser Ala Ile Arg Gln Gln Ile Glu Ser 
                245                 250                 255     


Tyr Pro Thr Asp Ser Ile Leu Glu Asp Gln Ser Asp Gln Arg Val Ile 
            260                 265                 270         


Ile Lys Leu Asn Ile His Val Gly Asn Ile Ser Leu Val Asp Gln Phe 
        275                 280                 285             


Glu Trp Asp Met Ser Glu Lys Glu Asn Ser Pro Glu Lys Phe Ala Leu 
    290                 295                 300                 


Lys Leu Cys Ser Glu Leu Gly Leu Gly Gly Glu Phe Val Thr Thr Ile 
305                 310                 315                 320 


Ala Tyr Ser Ile Arg Gly Gln Leu Ser Trp His Gln Lys Thr Tyr Ala 
                325                 330                 335     


Phe Ser Glu Asn Pro Leu Pro Thr Val Glu Ile Ala Ile Arg Asn Thr 
            340                 345                 350         


Gly Asp Ala Asp Gln Trp Cys Pro Leu Leu Glu Thr Leu Thr Asp Ala 
        355                 360                 365             


Glu Met Glu Lys Lys Ile Arg Asp Gln Asp Arg Asn Thr Arg Arg Met 
    370                 375                 380                 


Arg Arg Leu Ala Asn Thr Ala Pro Ala Trp 
385                 390                 


<210> 7
<211> 1803
<212> DNA
<213> Homo sapiens

<400> 7
tttgtttgag cggcggcgcg cgcgtcagcg tcaacgccag cgcctgcgca ctgagggcgg       60

cctggtcgtc gtctgcggcg gcggcggcgg ctgaggagcc cggctgaggc gccagtaccc      120

ggcccggtcc gcatttcgcc ttccggcttc ggtttccctc ggcccagcac gccccggccc      180

cgccccagcc ctcctgatcc ctcgcagccc ggctccggcc gcccgcctct gccgccgcaa      240

tgatgatgat ggcgctgagc aagaccttcg ggcagaagcc cgtgaagttc cagctggagg      300

acgacggcga gttctacatg atcggctccg aggtgggaaa ctacctccgt atgttccgag      360

gttctctgta caagagatac ccctcactct ggaggcgact agccactgtg gaagagagga      420

agaaaatagt tgcatcgtca catggtaaaa aaacaaaacc taacactaag gatcacggat      480

acacgactct agccaccagt gtgaccctgt taaaagcctc ggaagtggaa gagattctgg      540

atggcaacga tgagaagtac aaggctgtgt ccatcagcac agagcccccc acctacctca      600

gggaacagaa ggccaagagg aacagccagt gggtacccac cctgcccaac agctcccacc      660

acttagatgc cgtgccatgc tccacaacca tcaacaggaa ccgcatgggc cgagacaaga      720

agagaacctt ccccctttgg tgtggatgca tcgctgcact caccctccgt gctgattccg      780

ccttagttct ccactttgat gaccatgacc cagctgtgat ccatgagaac gcatctcagc      840

ccgaggtgct ggtccccatc cggctggaca tggagatcga tgggcagaag ctgcgagacg      900

ccttcacctg gaacatgaat gagaagttga tgacgcctga gatgttttca gaaatcctct      960

gtgacgatct ggatttgaac ccgctgacgt ttgtgccagc catcgcctct gccatcagac     1020

agcagatcga gtcctacccc acggacagca tcctggagga ccagtcagac cagcgcgtca     1080

tcatcaagct gaacatccat gtgggaaaca tttccctggt ggaccagttt gagtgggaca     1140

tgtcagagaa ggagaactca ccagagaagt ttgccctgaa gctgtgctcg gagctggggt     1200

tgggcgggga gtttgtcacc accatcgcat acagcatccg gggacagctg agctggcatc     1260

agaagaccta cgccttcagc gagaaccctc tgcccacagt ggagattgcc atccggaaca     1320

cgggcgatgc ggaccagtgg tgcccactgc tggagactct gacagacgct gagatggaga     1380

agaagatccg cgaccaggac aggaacacga ggcggatgag gcgtcttgcc aacacggccc     1440

cggcctggta accagcccat cagcacacgg ctcccacgga gcatctcaga agattgggcc     1500

gcctctcctc catcttctgg caaggacaga ggcgagggga cagcccagcg ccatcctgag     1560

gatcgggtgg gggtggagtg ggggcttcca ggtggccctt cccggcacac attccatttg     1620

ttgagcccca gtcctgcccc ccaccccacc ctccctaccc ctccccagtc tctggggtca     1680

ggaagaaacc ttattttagg ttgtgttttg tttttgtata ggagccccag gcagggctag     1740

taacagtttt taaataaaag gcaacaggtc atgttcaatt tcttcaacaa aaaaaaaaaa     1800

aaa                                                                   1803


<210> 8
<211> 403
<212> PRT
<213> Homo sapiens

<400> 8
Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Gly Lys Lys Thr Lys Pro Asn Thr Lys Asp His Gly 
65                  70                  75                  80  


Tyr Thr Thr Leu Ala Thr Ser Val Thr Leu Leu Lys Ala Ser Glu Val 
                85                  90                  95      


Glu Glu Ile Leu Asp Gly Asn Asp Glu Lys Tyr Lys Ala Val Ser Ile 
            100                 105                 110         


Ser Thr Glu Pro Pro Thr Tyr Leu Arg Glu Gln Lys Ala Lys Arg Asn 
        115                 120                 125             


Ser Gln Trp Val Pro Thr Leu Pro Asn Ser Ser His His Leu Asp Ala 
    130                 135                 140                 


Val Pro Cys Ser Thr Thr Ile Asn Arg Asn Arg Met Gly Arg Asp Lys 
145                 150                 155                 160 


Lys Arg Thr Phe Pro Leu Trp Cys Gly Cys Ile Ala Ala Leu Thr Leu 
                165                 170                 175     


Arg Ala Asp Ser Ala Leu Val Leu His Phe Asp Asp His Asp Pro Ala 
            180                 185                 190         


Val Ile His Glu Asn Ala Ser Gln Pro Glu Val Leu Val Pro Ile Arg 
        195                 200                 205             


Leu Asp Met Glu Ile Asp Gly Gln Lys Leu Arg Asp Ala Phe Thr Trp 
    210                 215                 220                 


Asn Met Asn Glu Lys Leu Met Thr Pro Glu Met Phe Ser Glu Ile Leu 
225                 230                 235                 240 


Cys Asp Asp Leu Asp Leu Asn Pro Leu Thr Phe Val Pro Ala Ile Ala 
                245                 250                 255     


Ser Ala Ile Arg Gln Gln Ile Glu Ser Tyr Pro Thr Asp Ser Ile Leu 
            260                 265                 270         


Glu Asp Gln Ser Asp Gln Arg Val Ile Ile Lys Leu Asn Ile His Val 
        275                 280                 285             


Gly Asn Ile Ser Leu Val Asp Gln Phe Glu Trp Asp Met Ser Glu Lys 
    290                 295                 300                 


Glu Asn Ser Pro Glu Lys Phe Ala Leu Lys Leu Cys Ser Glu Leu Gly 
305                 310                 315                 320 


Leu Gly Gly Glu Phe Val Thr Thr Ile Ala Tyr Ser Ile Arg Gly Gln 
                325                 330                 335     


Leu Ser Trp His Gln Lys Thr Tyr Ala Phe Ser Glu Asn Pro Leu Pro 
            340                 345                 350         


Thr Val Glu Ile Ala Ile Arg Asn Thr Gly Asp Ala Asp Gln Trp Cys 
        355                 360                 365             


Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg 
    370                 375                 380                 


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
385                 390                 395                 400 


Pro Ala Trp 
            


<210> 9
<211> 1674
<212> DNA
<213> Mus musculus

<400> 9
gtcagcttct ccacgcatgc gcaccgaggg cggcctgctc gttgcagaga cggccaagga       60

gcccagtagt gacacgagcg ctcgcccggt tcgcccggct tgccctgccc gaccttcacc      120

tccaggcctc cgttcctttc ggtccgacgc gcctcggccc cgccctagcc caccggattc      180

tttccagctc gaccccggct gccggtttcc cccgccgcca tgatgatgat ggcgttgagc      240

aagaccttcg ggcagaagcc cgtcaagttt cagctggagg acgacgggga gttctacatg      300

atcggctccg aggtgggaaa ctacctgcgt atgttccgag gttctctgta caagagatac      360

ccctcactct ggcggcgact agccactgtg gaagaaagga agaaaatagt ggcatcgtca      420

catggtaaaa aaacaaaacc taacactaag gatcatggat ataccaccct ggccaccagc      480

gtgacactcc tgaaagcctc agaggtagaa gagatcctgg atggcaatga cgagaagtac      540

aaggctgtgt ccatcagcac agagcccccg acctacctca gggagcagaa ggccaagagg      600

aacagccagt gggtccccac cctgcccaac agctcccacc acctggatgc tgtgccctgt      660

tccaccacca tcaacaggaa ccgcatgggt cgggacaaga agagaacctt ccccttgtgc      720

tttgatgacc acgacccagc tgtgatccat gagaatgcgt cacagcctga ggtgctggtg      780

cccatccggc tcgacatgga gatcgacggg cagaagctgc gagacgcttt tacctggaac      840

atgaatgaga agctaatgac tcctgagatg ttttcagaaa tactttgtga tgacctggat      900

ttgaatccac tgacttttgt gccagctatt gcctctgcca ttcgacagca gattgagtcc      960

taccccacag acagcatcct agaggatcaa tccgaccagc gtgtcatcat caagctgaac     1020

atccacgtgg ggaacatctc cctggtggac cagtttgagt gggacatgtc agagaaagag     1080

aactccccag agaagtttgc cctgaagctg tgctcagagc tgggcttggg cggggagttt     1140

gtcaccacca ttgcatacag catccgagga cagctgagct ggcaccagaa gacctatgcc     1200

ttcagtgaga acccacttcc cacagtggag attgccatcc gaaataccgg agatgctgac     1260

cagtggtgcc ccctgctgga gacactgact gatgccgaga tggagaaaaa gatccgggat     1320

caagatagga acacaaggcg aatgaggcgt cttgccaaca ctgccccagc ctggtgatga     1380

agacatccat gctcgacctc tacggagcat ctcagactgc ctttccttcc tctgtggaaa     1440

gagaaaggca aagggacagc tggtgccatc ctgaggactg gggtaggagc ctcctaggtg     1500

cctcccttca gcacacattc catttgctaa accccaacac tgtcccccag agtctagagt     1560

cggaagcagc ctcattttgg gttgtgtttt gtttttgtat aggagcccag gcagggctgg     1620

taacactttt taaataaaaa gtaccatgtt caatttcaaa aaaaaaaaaa aaaa           1674


<210> 10
<211> 385
<212> PRT
<213> Mus musculus

<400> 10
Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Gly Lys Lys Thr Lys Pro Asn Thr Lys Asp His Gly 
65                  70                  75                  80  


Tyr Thr Thr Leu Ala Thr Ser Val Thr Leu Leu Lys Ala Ser Glu Val 
                85                  90                  95      


Glu Glu Ile Leu Asp Gly Asn Asp Glu Lys Tyr Lys Ala Val Ser Ile 
            100                 105                 110         


Ser Thr Glu Pro Pro Thr Tyr Leu Arg Glu Gln Lys Ala Lys Arg Asn 
        115                 120                 125             


Ser Gln Trp Val Pro Thr Leu Pro Asn Ser Ser His His Leu Asp Ala 
    130                 135                 140                 


Val Pro Cys Ser Thr Thr Ile Asn Arg Asn Arg Met Gly Arg Asp Lys 
145                 150                 155                 160 


Lys Arg Thr Phe Pro Leu Cys Phe Asp Asp His Asp Pro Ala Val Ile 
                165                 170                 175     


His Glu Asn Ala Ser Gln Pro Glu Val Leu Val Pro Ile Arg Leu Asp 
            180                 185                 190         


Met Glu Ile Asp Gly Gln Lys Leu Arg Asp Ala Phe Thr Trp Asn Met 
        195                 200                 205             


Asn Glu Lys Leu Met Thr Pro Glu Met Phe Ser Glu Ile Leu Cys Asp 
    210                 215                 220                 


Asp Leu Asp Leu Asn Pro Leu Thr Phe Val Pro Ala Ile Ala Ser Ala 
225                 230                 235                 240 


Ile Arg Gln Gln Ile Glu Ser Tyr Pro Thr Asp Ser Ile Leu Glu Asp 
                245                 250                 255     


Gln Ser Asp Gln Arg Val Ile Ile Lys Leu Asn Ile His Val Gly Asn 
            260                 265                 270         


Ile Ser Leu Val Asp Gln Phe Glu Trp Asp Met Ser Glu Lys Glu Asn 
        275                 280                 285             


Ser Pro Glu Lys Phe Ala Leu Lys Leu Cys Ser Glu Leu Gly Leu Gly 
    290                 295                 300                 


Gly Glu Phe Val Thr Thr Ile Ala Tyr Ser Ile Arg Gly Gln Leu Ser 
305                 310                 315                 320 


Trp His Gln Lys Thr Tyr Ala Phe Ser Glu Asn Pro Leu Pro Thr Val 
                325                 330                 335     


Glu Ile Ala Ile Arg Asn Thr Gly Asp Ala Asp Gln Trp Cys Pro Leu 
            340                 345                 350         


Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg Asp Gln 
        355                 360                 365             


Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala Pro Ala 
    370                 375                 380                 


Trp 
385 


<210> 11
<211> 1647
<212> DNA
<213> Mus musculus

<400> 11
gtcagcttct ccacgcatgc gcaccgaggg cggcctgctc gttgcagaga cggccaagga       60

gcccagtagt gacacgagcg ctcgcccggt tcgcccggct tgccctgccc gaccttcacc      120

tccaggcctc cgttcctttc ggtccgacgc gcctcggccc cgccctagcc caccggattc      180

tttccagctc gaccccggct gccggtttcc cccgccgcca tgatgatgat ggcgttgagc      240

aagaccttcg ggcagaagcc cgtcaagttt cagctggagg acgacgggga gttctacatg      300

atcggctccg aggtgggaaa ctacctgcgt atgttccgag gttctctgta caagagatac      360

ccctcactct ggcggcgact agccactgtg gaagaaagga agaaaatagt ggcatcgtca      420

catgatcatg gatataccac cctggccacc agcgtgacac tcctgaaagc ctcagaggta      480

gaagagatcc tggatggcaa tgacgagaag tacaaggctg tgtccatcag cacagagccc      540

ccgacctacc tcagggagca gaaggccaag aggaacagcc agtgggtccc caccctgccc      600

aacagctccc accacctgga tgctgtgccc tgttccacca ccatcaacag gaaccgcatg      660

ggtcgggaca agaagagaac cttccccttg tgctttgatg accacgaccc agctgtgatc      720

catgagaatg cgtcacagcc tgaggtgctg gtgcccatcc ggctcgacat ggagatcgac      780

gggcagaagc tgcgagacgc ttttacctgg aacatgaatg agaagctaat gactcctgag      840

atgttttcag aaatactttg tgatgacctg gatttgaatc cactgacttt tgtgccagct      900

attgcctctg ccattcgaca gcagattgag tcctacccca cagacagcat cctagaggat      960

caatccgacc agcgtgtcat catcaagctg aacatccacg tggggaacat ctccctggtg     1020

gaccagtttg agtgggacat gtcagagaaa gagaactccc cagagaagtt tgccctgaag     1080

ctgtgctcag agctgggctt gggcggggag tttgtcacca ccattgcata cagcatccga     1140

ggacagctga gctggcacca gaagacctat gccttcagtg agaacccact tcccacagtg     1200

gagattgcca tccgaaatac cggagatgct gaccagtggt gccccctgct ggagacactg     1260

actgatgccg agatggagaa aaagatccgg gatcaagata ggaacacaag gcgaatgagg     1320

cgtcttgcca acactgcccc agcctggtga tgaagacatc catgctcgac ctctacggag     1380

catctcagac tgcctttcct tcctctgtgg aaagagaaag gcaaagggac agctggtgcc     1440

atcctgagga ctggggtagg agcctcctag gtgcctccct tcagcacaca ttccatttgc     1500

taaaccccaa cactgtcccc cagagtctag agtcggaagc agcctcattt tgggttgtgt     1560

tttgtttttg tataggagcc caggcagggc tggtaacact ttttaaataa aaagtaccat     1620

gttcaatttc aaaaaaaaaa aaaaaaa                                         1647


<210> 12
<211> 376
<212> PRT
<213> Mus musculus

<400> 12
Met Met Met Met Ala Leu Ser Lys Thr Phe Gly Gln Lys Pro Val Lys 
1               5                   10                  15      


Phe Gln Leu Glu Asp Asp Gly Glu Phe Tyr Met Ile Gly Ser Glu Val 
            20                  25                  30          


Gly Asn Tyr Leu Arg Met Phe Arg Gly Ser Leu Tyr Lys Arg Tyr Pro 
        35                  40                  45              


Ser Leu Trp Arg Arg Leu Ala Thr Val Glu Glu Arg Lys Lys Ile Val 
    50                  55                  60                  


Ala Ser Ser His Asp His Gly Tyr Thr Thr Leu Ala Thr Ser Val Thr 
65                  70                  75                  80  


Leu Leu Lys Ala Ser Glu Val Glu Glu Ile Leu Asp Gly Asn Asp Glu 
                85                  90                  95      


Lys Tyr Lys Ala Val Ser Ile Ser Thr Glu Pro Pro Thr Tyr Leu Arg 
            100                 105                 110         


Glu Gln Lys Ala Lys Arg Asn Ser Gln Trp Val Pro Thr Leu Pro Asn 
        115                 120                 125             


Ser Ser His His Leu Asp Ala Val Pro Cys Ser Thr Thr Ile Asn Arg 
    130                 135                 140                 


Asn Arg Met Gly Arg Asp Lys Lys Arg Thr Phe Pro Leu Cys Phe Asp 
145                 150                 155                 160 


Asp His Asp Pro Ala Val Ile His Glu Asn Ala Ser Gln Pro Glu Val 
                165                 170                 175     


Leu Val Pro Ile Arg Leu Asp Met Glu Ile Asp Gly Gln Lys Leu Arg 
            180                 185                 190         


Asp Ala Phe Thr Trp Asn Met Asn Glu Lys Leu Met Thr Pro Glu Met 
        195                 200                 205             


Phe Ser Glu Ile Leu Cys Asp Asp Leu Asp Leu Asn Pro Leu Thr Phe 
    210                 215                 220                 


Val Pro Ala Ile Ala Ser Ala Ile Arg Gln Gln Ile Glu Ser Tyr Pro 
225                 230                 235                 240 


Thr Asp Ser Ile Leu Glu Asp Gln Ser Asp Gln Arg Val Ile Ile Lys 
                245                 250                 255     


Leu Asn Ile His Val Gly Asn Ile Ser Leu Val Asp Gln Phe Glu Trp 
            260                 265                 270         


Asp Met Ser Glu Lys Glu Asn Ser Pro Glu Lys Phe Ala Leu Lys Leu 
        275                 280                 285             


Cys Ser Glu Leu Gly Leu Gly Gly Glu Phe Val Thr Thr Ile Ala Tyr 
    290                 295                 300                 


Ser Ile Arg Gly Gln Leu Ser Trp His Gln Lys Thr Tyr Ala Phe Ser 
305                 310                 315                 320 


Glu Asn Pro Leu Pro Thr Val Glu Ile Ala Ile Arg Asn Thr Gly Asp 
                325                 330                 335     


Ala Asp Gln Trp Cys Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met 
            340                 345                 350         


Glu Lys Lys Ile Arg Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg 
        355                 360                 365             


Leu Ala Asn Thr Ala Pro Ala Trp 
    370                 375     


<210> 13
<211> 35
<212> PRT
<213> Homo sapiens

<400> 13
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 14
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Ile Arg Asp 
1               5                   10                  15      


Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala Pro 
            20                  25                  30          


Ala Trp 
        


<210> 15
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg His Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 16
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Cys 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 17
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Asn Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 18
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Gln Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 19
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Ala Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 20
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Glu Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 21
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Arg Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 22
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Pro Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 23
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ala Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 24
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Ala Ala Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 25
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Glu Glu Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 26
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Ala Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 27
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Ala Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


Pro Ala Trp 
        35  


<210> 28
<211> 35
<212> PRT
<213> Saccharomyces cerevisiae

<400> 28
Pro Asn Leu Leu Gln Ile Ser Ala Ala Glu Leu Glu Arg Leu Asp Lys 
1               5                   10                  15      


Asp Lys Asp Arg Asp Thr Arg Arg Lys Arg Arg Gln Gly Arg Ser Asn 
            20                  25                  30          


Arg Arg Gly 
        35  


<210> 29
<211> 35
<212> PRT
<213> Saccharomyces cerevisiae

<400> 29
Pro Arg Val Glu Ile Leu Thr Lys Glu Glu Ile Gln Lys Arg Glu Ile 
1               5                   10                  15      


Glu Lys Glu Arg Asn Leu Arg Arg Leu Lys Arg Glu Thr Asp Arg Leu 
            20                  25                  30          


Ser Arg Arg 
        35  


<210> 30
<211> 35
<212> PRT
<213> Caenorhabditis elegans

<400> 30
Pro Phe Leu Glu Thr Leu Thr Asp Ala Glu Ile Glu Lys Lys Met Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Val Gly Gly Gly 
            20                  25                  30          


Phe Asn Tyr 
        35  


<210> 31
<211> 35
<212> PRT
<213> Drosophila melanogaster

<400> 31
Pro Phe Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Thr 
            20                  25                  30          


Thr Gly Trp 
        35  


<210> 32
<211> 32
<212> PRT
<213> Homo sapiens

<400> 32
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


<210> 33
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Ile Arg Asp 
1               5                   10                  15      


Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30      


<210> 34
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg His Leu Ala Asn Thr Ala 
            20                  25                  30          


<210> 35
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Cys 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


<210> 36
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Asn Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Arg Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


<210> 37
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys Ile Arg 
1               5                   10                  15      


Asp Gln Asp Arg Asn Thr Arg Gln Met Arg Arg Leu Ala Asn Thr Ala 
            20                  25                  30          


<210> 38
<211> 22
<212> PRT
<213> Homo sapiens

<400> 38
Thr Asp Ala Glu Met Glu Lys Lys Ile Arg Asp Gln Asp Arg Asn Thr 
1               5                   10                  15      


Arg Arg Met Arg Arg Leu 
            20          


<210> 39
<211> 21
<212> PRT
<213> Homo sapiens

<400> 39
Thr Asp Ala Glu Met Glu Lys Lys Ile Arg Asp Gln Asp Arg Asn Thr 
1               5                   10                  15      


Arg Arg Met Arg Arg 
            20      


<210> 40
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
ggagaagaag atccgcgacc agg                                               23


<210> 41
<211> 147
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
ccggaacacg ggcgatgcgg accagtggtg cccactgctg gagactctga cagacgctga       60

gatggaaaaa atacgcgatc aagacaggaa cacgaggtac ccctggccct gtggtcctgg      120

gctctgccca caggcacctg gctttcc                                          147


<210> 42
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Thr Glu Asn Thr Lys Leu Asp Leu Met Arg Ile Pro Glu Asn Lys Leu 
1               5                   10                  15      


Ala Arg Ala Thr Arg Trp Arg Gln Thr Asp Leu Glu Ala Arg Pro Met 
            20                  25                  30          


Asp Ala Arg 
        35  


<210> 43
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Met Ala Pro Pro Gly Met Arg Leu Arg Ser Gly Arg Ser Thr Gly Ala 
1               5                   10                  15      


Pro Leu Thr Arg Gly Ser Cys 
            20              


<210> 44
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
ggaattgtga gcgctcacaa ttcc                                              24


<210> 45
<211> 41
<212> PRT
<213> Homo sapiens

<400> 45
Gly Pro Leu Gly Ser Met Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu 
1               5                   10                  15      


Met Glu Lys Lys Ile Arg Asp Gln Asp Arg Asn Thr Arg Arg Met Arg 
            20                  25                  30          


Arg Leu Ala Asn Thr Ala Pro Ala Trp 
        35                  40      


<210> 46
<211> 150
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (71)..(73)
<223> "aag" or absent

<400> 46
ccggaacacg ggcgatgcgg accagtggtg cccactgctg gagactctga cagacgctga       60

gatggaraar nnnatmcgcg aycargacag gaacacgagg tacccctggc cctgtggtcc      120

tgggctctgc ccacaggcac ctggctttcc                                       150


<210> 47
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (24)..(24)
<223> K or absent

<400> 47
Arg Asn Thr Gly Asp Ala Asp Gln Trp Cys Pro Leu Leu Glu Thr Leu 
1               5                   10                  15      


Thr Asp Ala Glu Met Glu Lys Xaa Ile Arg Asp Gln Asp Arg Asn Thr 
            20                  25                  30          


Arg Tyr Pro Trp Pro Cys Gly Pro Gly Leu Cys Pro Gln Ala Pro Gly 
        35                  40                  45              


Phe 
    


<210> 48
<211> 150
<212> DNA
<213> Homo sapiens

<400> 48
ccggaacacg ggcgatgcgg accagtggtg cccactgctg gagactctga cagacgctga       60

gatggagaag aagatccgcg accaggacag gaacacgagg tacccctggc cctgtggtcc      120

tgggctctgc ccacaggcac ctggctttcc                                       150


<210> 49
<211> 49
<212> PRT
<213> Homo sapiens

<400> 49
Arg Asn Thr Gly Asp Ala Asp Gln Trp Cys Pro Leu Leu Glu Thr Leu 
1               5                   10                  15      


Thr Asp Ala Glu Met Glu Lys Lys Ile Arg Asp Gln Asp Arg Asn Thr 
            20                  25                  30          


Arg Tyr Pro Trp Pro Cys Gly Pro Gly Leu Cys Pro Gln Ala Pro Gly 
        35                  40                  45              


Phe 
    


<210> 50
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Arg Asn Thr Gly Asp Ala Asp Gln Trp Cys Pro Leu Leu Glu Thr Leu 
1               5                   10                  15      


Thr Asp Ala Glu Met Glu Lys Ile Arg Asp Gln Asp Arg Asn Thr Arg 
            20                  25                  30          


Tyr Pro Trp Pro Cys Gly Pro Gly Leu Cys Pro Gln Ala Pro Gly Phe 
        35                  40                  45              


<210> 51
<211> 174
<212> DNA
<213> Homo sapiens

<400> 51
tgcccacagt ggagattgcc atccggaaca cgggcgatgc ggaccagtgg tgcccactgc       60

tggagactct gacagacgct gagatggaga agaagatccg cgaccaggac aggaacacga      120

ggtacccctg gccctgtggt cctgggctct gcccacaggc acctggcttt ccag            174


<210> 52
<211> 58
<212> PRT
<213> Homo sapiens

<400> 52
Leu Pro Thr Val Glu Ile Ala Ile Arg Asn Thr Gly Asp Ala Asp Gln 
1               5                   10                  15      


Trp Cys Pro Leu Leu Glu Thr Leu Thr Asp Ala Glu Met Glu Lys Lys 
            20                  25                  30          


Ile Arg Asp Gln Asp Arg Asn Thr Arg Tyr Pro Trp Pro Cys Gly Pro 
        35                  40                  45              


Gly Leu Cys Pro Gln Ala Pro Gly Phe Pro 
    50                  55              


<210> 53
<211> 171
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 53
tgcccacagt ggagattgcc atccggaaca cgggcgatgc ggaccagtgg tgcccactgc       60

tggagactct gacagacgct gagatggaaa aaatacgcga tcaagacagg aacacgaggt      120

acccctggcc ctgtggtcct gggctctgcc cacaggcacc tggctttcca g               171


<210> 54
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
tgcccacagt ggagattgcc ctgtggtcct gggctctgcc cacaggcacc tggctttcca       60

g                                                                       61



