                         SEQUENCE LISTING

<110>  Stichting Het Nederlands Kanker Instituut- Antoni van 
       Leeuwenhoek Ziekenhuis
 
<120>  Chimeric polypeptide for regulating immune cells

<130>  P79325PC

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  2
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile 
    50                  55  


<210>  3
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        35                  40                  45  


<210>  4
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
        35                  40                  45  


<210>  5
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys 
1               5                   10                  15      


Ser Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr 
            20                  25                  30          


Glu Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40          


<210>  6
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  6

Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210>  7
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Phe Tyr Gly Ser Ile Ser Arg Ala Glu Ala Glu Glu His Leu Lys 
1               5                   10                  15      


Leu Ala Gly Met Ala Asp Gly Leu Phe Leu Leu Arg Gln Cys Leu Arg 
            20                  25                  30          


Ser Leu Gly Gly Tyr Val Leu Ser Leu Val His Asp Val Arg Phe His 
        35                  40                  45              


His Phe Pro Ile Glu Arg Gln Leu Asn Gly Thr Tyr Ala Ile Ala Gly 
    50                  55                  60                  


Gly Lys Ala His Cys Gly Pro Ala Glu Leu Cys Glu Phe Tyr Ser Arg 
65                  70                  75                  80  


Asp Pro Asp Gly Leu Pro Cys Asn Leu Arg Lys Pro Cys 
                85                  90              


<210>  8
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  8

Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys Leu Tyr 
1               5                   10                  15      


Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg Lys Glu 
            20                  25                  30          


Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val Tyr His 
        35                  40                  45              


Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro Glu Gly 
    50                  55                  60                  


Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys Leu Lys 
65                  70                  75                  80  


Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys 
                85                  90          


<210>  9
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Phe Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val 
1               5                   10                  15      


Gln Gly Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn 
            20                  25                  30          


Tyr Leu Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His 
        35                  40                  45              


His Tyr Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly 
    50                  55                  60                  


Gly Arg Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln 
65                  70                  75                  80  


Glu Ser Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe 
                85                  90              


<210>  10
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  10

Trp Phe His Gly Lys Ile Ser Arg Glu Glu Ser Glu Gln Ile Val Leu 
1               5                   10                  15      


Ile Gly Ser Lys Thr Asn Gly Lys Phe Leu Ile Arg Ala Arg Asp Asn 
            20                  25                  30          


Asn Gly Ser Tyr Ala Leu Cys Leu Leu His Glu Gly Lys Val Leu His 
        35                  40                  45              


Tyr Arg Ile Asp Lys Asp Lys Thr Gly Lys Leu Ser Ile Pro Glu Gly 
    50                  55                  60                  


Lys Lys Phe Asp Thr Leu Trp Gln Leu Val Glu His Tyr Ser Tyr Lys 
65                  70                  75                  80  


Ala Asp Gly Leu Leu Arg Val Leu Thr Val Pro Cys 
                85                  90          


<210>  11
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  11

Trp Phe Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu 
1               5                   10                  15      


Ala Pro Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser 
            20                  25                  30          


Thr Ala Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln 
        35                  40                  45              


Gly Glu Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly 
    50                  55                  60                  


Phe Tyr Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val 
65                  70                  75                  80  


Arg His Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg 
                85                  90                  95      


Pro Cys 
        


<210>  12
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly 
            260                 


<210>  13
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe 
1               5                   10                  15      


Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly 
            20                  25                  30          


Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu 
        35                  40                  45              


Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr 
    50                  55                  60                  


Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg 
65                  70                  75                  80  


Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser 
                85                  90                  95      


Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly 
            100                 105                 110         


Val Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile 
        115                 120                 125             


Arg Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu 
    130                 135                 140                 


Gln Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr 
145                 150                 155                 160 


Thr Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu 
                165                 170                 175     


Glu Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe 
            180                 185                 190         


Leu Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu 
        195                 200                 205             


His Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly 
    210                 215                 220                 


Lys Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu 
225                 230                 235                 240 


Val Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr 
                245                 250                 255     


Val Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly 
            260                 265                 270         


Arg Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly 
        275                 280                 285         


<210>  14
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly 
                245                 250                 


<210>  15
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala Gly Arg 
1               5                   10                  15      


Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr Glu Ala 
            20                  25                  30          


Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly Ile Tyr 
        35                  40                  45              


Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser Glu Val 
    50                  55                  60                  


Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val Tyr Ala 
65                  70                  75                  80  


Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala Arg Asn 
                85                  90                  95      


Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg Ser 
            100                 105                 110     


<210>  16
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Arg Lys Gly Arg Cys Ser Val Pro Ala Phe Cys Ser Ser Gln Ala 
1               5                   10                  15      


Glu Ala Pro Ala Asp Thr Pro Glu Pro Thr Ala Gly His Thr Leu Tyr 
            20                  25                  30          


Ser Val Leu Ser Gln Gly Tyr Glu Lys Leu Asp Thr Pro Leu Arg Pro 
        35                  40                  45              


Ala Arg Gln Gln Pro Thr Pro Thr Ser Asp Ser Ser Ser Asp Ser Asn 
    50                  55                  60                  


Leu Thr Thr Glu Glu Asp Glu Asp Arg Pro Glu Val His Lys Pro Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Glu Val Phe Asp Gln Val Thr Gln Glu Gly Ala Gly 
                85                  90                  95      


His Asp Pro Ala Pro Glu Gly Gln Ala Asp Tyr Asp Pro Val Thr Pro 
            100                 105                 110         


Tyr Val Thr Glu Val Glu Ser Val Val Gly Glu Asn Thr Met Tyr Ala 
        115                 120                 125             


Gln Val Phe Asn Leu Gln Gly Lys Thr Pro Val Ser Gln Lys Glu Glu 
    130                 135                 140                 


Ser Ser Ala Thr Ile Tyr Cys Ser Ile Arg Lys Pro Gln Val Val Pro 
145                 150                 155                 160 


Pro Pro Gln Gln Asn Asp Leu Glu Ile Pro Glu Ser Pro Thr Tyr Glu 
                165                 170                 175     


Asn Phe Thr 
            


<210>  17
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
1               5                   10                  15      


Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr 
            20                  25                  30          


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val 
        35                  40                  45              


Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser 
    50                  55                  60                  


Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro 
65                  70                  75                  80  


Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro 
                85                  90                  95      


Leu 
    


<210>  18
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  18

Lys Cys Tyr Phe Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu 
1               5                   10                  15      


Met Ser Arg Pro Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met 
            20                  25                  30          


Ser Asp Pro Asn Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp 
        35                  40                  45              


Val Arg Asn His Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu 
    50                  55                  60                  


Asn Ser Asp Val Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser 
65                  70                  75                  80  


His Lys Asp Leu Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val 
                85                  90                  95      


Arg Lys Ala Val Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu 
            100                 105                 110         


Gly Ser Leu Asp Gly Thr 
        115             


<210>  19
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Ile Arg Gln Lys Lys Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu 
1               5                   10                  15      


His Glu Pro Glu Lys Asn Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp 
            20                  25                  30          


Ile Thr Tyr Ala Asp Leu Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro 
        35                  40                  45              


Gln Ala Ala Glu Pro Asn Asn His Thr Glu Tyr Ala Ser Ile Gln Thr 
    50                  55                  60                  


Ser Pro Gln Pro Ala Ser Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp 
65                  70                  75                  80  


Met Val His Leu Asn Arg Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu 
                85                  90                  95      


Pro Ser Phe Ser Glu Tyr Ala Ser Val Gln Val Pro Arg Lys 
            100                 105                 110 


<210>  20
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  20

Lys Ile Cys Arg Lys Glu Ala Arg Lys Arg Ala Ala Ala Glu Gln Asp 
1               5                   10                  15      


Val Pro Ser Thr Leu Gly Pro Ile Ser Gln Gly His Gln His Glu Cys 
            20                  25                  30          


Ser Ala Gly Ser Ser Gln Asp His Pro Pro Pro Gly Ala Ala Thr Tyr 
        35                  40                  45              


Thr Pro Gly Lys Gly Glu Glu Gln Glu Leu His Tyr Ala Ser Leu Ser 
    50                  55                  60                  


Phe Gln Gly Leu Arg Leu Trp Glu Pro Ala Asp Gln Glu Ala Pro Ser 
65                  70                  75                  80  


Thr Thr Glu Tyr Ser Glu Ile Lys Ile His Thr Gly Gln Pro Leu Arg 
                85                  90                  95      


Gly Pro Gly Phe Gly Leu Gln Leu Glu Arg Glu Met Ser Gly Met Val 
            100                 105                 110         


Pro Lys 
        


<210>  21
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Ala Arg Arg Lys Gln Ala Ala Gly Arg Pro Glu Lys Met Asp Asp 
1               5                   10                  15      


Glu Asp Pro Ile Met Gly Thr Ile Thr Ser Gly Ser Arg Lys Lys Pro 
            20                  25                  30          


Trp Pro Asp Ser Pro Gly Asp Gln Ala Ser Pro Pro Gly Asp Ala Pro 
        35                  40                  45              


Pro Leu Glu Glu Gln Lys Glu Leu His Tyr Ala Ser Leu Ser Phe Ser 
    50                  55                  60                  


Glu Met Lys Ser Arg Glu Pro Lys Asp Gln Glu Ala Pro Ser Thr Thr 
65                  70                  75                  80  


Glu Tyr Ser Glu Ile Lys Thr Ser Lys 
                85                  


<210>  22
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  22

Val Arg Ser Cys Arg Lys Lys Ser Ala Arg Pro Ala Ala Gly Val Gly 
1               5                   10                  15      


Asp Thr Gly Ile Glu Asp Ala Asn Ala Val Arg Gly Ser Ala Ser Gln 
            20                  25                  30          


Gly Pro Leu Thr Glu Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln Pro 
        35                  40                  45              


Pro Pro Ala Ser Ala Arg Ser Ser Val Gly Glu Gly Glu Leu Gln Tyr 
    50                  55                  60                  


Ala Ser Leu Ser Phe Gln Met Val Lys Pro Trp Asp Ser Arg Gly Gln 
65                  70                  75                  80  


Glu Ala Thr Asp Thr Glu Tyr Ser Glu Ile Lys Ile His Arg 
                85                  90                  


<210>  23
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  23

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Asp Glu Met Glu Glu Cys Ser Gln His Leu Pro Gly Ala Gly Ser 
    370                 375                 380                 


Ser Gly Asp Ile Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ser 
385                 390                 395                 400 


Gly Thr Gly Ser Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala Tyr Ala 
                405                 410                 415     


Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly 
            420                 425                 430         


Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala 
        435                 440                 445             


Thr Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Ala Val 
    450                 455                 460                 


Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val 
465                 470                 475                 480 


Ile Gln Met Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro Ala 
                485                 490                 495     


Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp 
            500                 505                 510         


Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg 
        515                 520                 525             


Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu 
    530                 535                 540                 


Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val 
545                 550                 555                 560 


Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val 
                565                 570                 575     


Asp Phe Ile Pro Val Glu Asn Leu Glu Thr Thr Met Arg Ser Pro Val 
            580                 585                 590         


Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Thr Leu Thr His Pro Ile 
        595                 600                 605             


Thr Lys Ile Asp Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp Leu 
    610                 615                 620                 


Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala 
625                 630                 635                 640 


Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val Ile Val Gly Arg 
                645                 650                 655     


Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp Arg Glu Val Leu 
            660                 665                 670         


Tyr 
    


<210>  24
<211>  687
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  24

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Arg Arg His Gln Gly 
            260                 265                 270         


Lys Gln Asn Glu Leu Ser Asp Thr Ala Gly Arg Glu Ile Asn Leu Val 
        275                 280                 285             


Asp Ala His Leu Lys Ser Glu Gln Thr Glu Ala Ser Thr Arg Gln Asn 
    290                 295                 300                 


Ser Gln Val Leu Leu Ser Glu Thr Gly Ile Tyr Asp Asn Asp Pro Asp 
305                 310                 315                 320 


Leu Cys Phe Arg Met Gln Glu Gly Ser Glu Val Tyr Ser Asn Pro Cys 
                325                 330                 335     


Leu Glu Glu Asn Lys Pro Gly Ile Val Tyr Ala Ser Leu Asn His Ser 
            340                 345                 350         


Val Ile Gly Pro Asn Ser Arg Leu Ala Arg Asn Val Lys Glu Ala Pro 
        355                 360                 365             


Thr Glu Tyr Ala Ser Ile Cys Val Arg Ser Ser Gly Gly Gly Ser Asp 
    370                 375                 380                 


Glu Met Glu Glu Cys Ser Gln His Leu Pro Gly Ala Gly Ser Ser Gly 
385                 390                 395                 400 


Asp Ile Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ser Gly Thr 
                405                 410                 415     


Gly Ser Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala Tyr Ala Gln Gln 
            420                 425                 430         


Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp 
        435                 440                 445             


Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln 
    450                 455                 460                 


Thr Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Ala Val Tyr His 
465                 470                 475                 480 


Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Ile Gln 
                485                 490                 495     


Met Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro Ala Pro Gln 
            500                 505                 510         


Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr 
        515                 520                 525             


Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp 
    530                 535                 540                 


Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly 
545                 550                 555                 560 


Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Leu 
                565                 570                 575     


Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe 
            580                 585                 590         


Ile Pro Val Glu Asn Leu Glu Thr Thr Met Arg Ser Pro Val Phe Thr 
        595                 600                 605             


Asp Asn Ser Ser Pro Pro Ala Val Thr Leu Thr His Pro Ile Thr Lys 
    610                 615                 620                 


Ile Asp Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val 
625                 630                 635                 640 


Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala 
                645                 650                 655     


Ala Tyr Cys Leu Ser Thr Gly Cys Val Val Ile Val Gly Arg Ile Val 
            660                 665                 670         


Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr 
        675                 680                 685         


<210>  25
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  25

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Arg Ile Arg Gln Lys 
            260                 265                 270         


Lys Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu His Glu Pro Glu Lys 
        275                 280                 285             


Asn Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp Ile Thr Tyr Ala Asp 
    290                 295                 300                 


Leu Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro Gln Ala Ala Glu Pro 
305                 310                 315                 320 


Asn Asn His Thr Glu Tyr Ala Ser Ile Gln Thr Ser Pro Gln Pro Ala 
                325                 330                 335     


Ser Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp Met Val His Leu Asn 
            340                 345                 350         


Arg Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu Pro Ser Phe Ser Glu 
        355                 360                 365             


Tyr Ala Ser Val Gln Val Pro Arg Lys Ser Gly Gly Gly Ser Asp Glu 
    370                 375                 380                 


Met Glu Glu Cys Ser Gln His Leu Pro Gly Ala Gly Ser Ser Gly Asp 
385                 390                 395                 400 


Ile Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ser Gly Thr Gly 
                405                 410                 415     


Ser Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
            420                 425                 430         


Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys 
        435                 440                 445             


Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln Thr 
    450                 455                 460                 


Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Ala Val Tyr His Gly 
465                 470                 475                 480 


Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met 
                485                 490                 495     


Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly 
            500                 505                 510         


Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu 
        515                 520                 525             


Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser 
    530                 535                 540                 


Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser 
545                 550                 555                 560 


Ser Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Leu Phe 
                565                 570                 575     


Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile 
            580                 585                 590         


Pro Val Glu Asn Leu Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp 
        595                 600                 605             


Asn Ser Ser Pro Pro Ala Val Thr Leu Thr His Pro Ile Thr Lys Ile 
    610                 615                 620                 


Asp Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val Val 
625                 630                 635                 640 


Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala Ala 
                645                 650                 655     


Tyr Cys Leu Ser Thr Gly Cys Val Val Ile Val Gly Arg Ile Val Leu 
            660                 665                 670         


Ser Gly Lys Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr 
        675                 680                 685     


<210>  26
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  26

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Lys Ala Arg Arg Lys 
            260                 265                 270         


Gln Ala Ala Gly Arg Pro Glu Lys Met Asp Asp Glu Asp Pro Ile Met 
        275                 280                 285             


Gly Thr Ile Thr Ser Gly Ser Arg Lys Lys Pro Trp Pro Asp Ser Pro 
    290                 295                 300                 


Gly Asp Gln Ala Ser Pro Pro Gly Asp Ala Pro Pro Leu Glu Glu Gln 
305                 310                 315                 320 


Lys Glu Leu His Tyr Ala Ser Leu Ser Phe Ser Glu Met Lys Ser Arg 
                325                 330                 335     


Glu Pro Lys Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr Ser Glu Ile 
            340                 345                 350         


Lys Thr Ser Lys Ser Gly Gly Gly Ser Asp Glu Met Glu Glu Cys Ser 
        355                 360                 365             


Gln His Leu Pro Gly Ala Gly Ser Ser Gly Asp Ile Met Asp Tyr Lys 
    370                 375                 380                 


Asp Asp Asp Asp Lys Gly Ser Ser Gly Thr Gly Ser Gly Ser Gly Thr 
385                 390                 395                 400 


Ser Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly 
                405                 410                 415     


Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly 
            420                 425                 430         


Glu Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys 
        435                 440                 445             


Ile Asn Gly Val Cys Trp Ala Val Tyr His Gly Ala Gly Thr Arg Thr 
    450                 455                 460                 


Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp 
465                 470                 475                 480 


Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr 
                485                 490                 495     


Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
            500                 505                 510         


Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu 
        515                 520                 525             


Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu 
    530                 535                 540                 


Leu Cys Pro Ala Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys 
545                 550                 555                 560 


Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu 
                565                 570                 575     


Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro 
            580                 585                 590         


Ala Val Thr Leu Thr His Pro Ile Thr Lys Ile Asp Thr Lys Tyr Ile 
        595                 600                 605             


Met Thr Cys Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val 
    610                 615                 620                 


Leu Val Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr 
625                 630                 635                 640 


Gly Cys Val Val Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala 
                645                 650                 655     


Ile Ile Pro Asp Arg Glu Val Leu Tyr 
            660                 665 


<210>  27
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  27

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Val Arg Ser Cys Arg 
            260                 265                 270         


Lys Lys Ser Ala Arg Pro Ala Ala Gly Val Gly Asp Thr Gly Ile Glu 
        275                 280                 285             


Asp Ala Asn Ala Val Arg Gly Ser Ala Ser Gln Gly Pro Leu Thr Glu 
    290                 295                 300                 


Pro Trp Ala Glu Asp Ser Pro Pro Asp Gln Pro Pro Pro Ala Ser Ala 
305                 310                 315                 320 


Arg Ser Ser Val Gly Glu Gly Glu Leu Gln Tyr Ala Ser Leu Ser Phe 
                325                 330                 335     


Gln Met Val Lys Pro Trp Asp Ser Arg Gly Gln Glu Ala Thr Asp Thr 
            340                 345                 350         


Glu Tyr Ser Glu Ile Lys Ile His Arg Ser Gly Gly Gly Ser Asp Glu 
        355                 360                 365             


Met Glu Glu Cys Ser Gln His Leu Pro Gly Ala Gly Ser Ser Gly Asp 
    370                 375                 380                 


Ile Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ser Gly Thr Gly 
385                 390                 395                 400 


Ser Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
                405                 410                 415     


Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys 
            420                 425                 430         


Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln Thr 
        435                 440                 445             


Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Ala Val Tyr His Gly 
    450                 455                 460                 


Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met 
465                 470                 475                 480 


Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly 
                485                 490                 495     


Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu 
            500                 505                 510         


Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser 
        515                 520                 525             


Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser 
    530                 535                 540                 


Ser Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Leu Phe 
545                 550                 555                 560 


Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile 
                565                 570                 575     


Pro Val Glu Asn Leu Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp 
            580                 585                 590         


Asn Ser Ser Pro Pro Ala Val Thr Leu Thr His Pro Ile Thr Lys Ile 
        595                 600                 605             


Asp Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val Val 
    610                 615                 620                 


Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala Ala 
625                 630                 635                 640 


Tyr Cys Leu Ser Thr Gly Cys Val Val Ile Val Gly Arg Ile Val Leu 
                645                 650                 655     


Ser Gly Lys Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr 
            660                 665                 670 


<210>  28
<211>  690
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  28

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Lys Ile Cys Arg Lys 
            260                 265                 270         


Glu Ala Arg Lys Arg Ala Ala Ala Glu Gln Asp Val Pro Ser Thr Leu 
        275                 280                 285             


Gly Pro Ile Ser Gln Gly His Gln His Glu Cys Ser Ala Gly Ser Ser 
    290                 295                 300                 


Gln Asp His Pro Pro Pro Gly Ala Ala Thr Tyr Thr Pro Gly Lys Gly 
305                 310                 315                 320 


Glu Glu Gln Glu Leu His Tyr Ala Ser Leu Ser Phe Gln Gly Leu Arg 
                325                 330                 335     


Leu Trp Glu Pro Ala Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr Ser 
            340                 345                 350         


Glu Ile Lys Ile His Thr Gly Gln Pro Leu Arg Gly Pro Gly Phe Gly 
        355                 360                 365             


Leu Gln Leu Glu Arg Glu Met Ser Gly Met Val Pro Lys Ser Gly Gly 
    370                 375                 380                 


Gly Ser Asp Glu Met Glu Glu Cys Ser Gln His Leu Pro Gly Ala Gly 
385                 390                 395                 400 


Ser Ser Gly Asp Ile Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser 
                405                 410                 415     


Ser Gly Thr Gly Ser Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala Tyr 
            420                 425                 430         


Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr 
        435                 440                 445             


Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr 
    450                 455                 460                 


Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Ala 
465                 470                 475                 480 


Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro 
                485                 490                 495     


Val Ile Gln Met Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro 
            500                 505                 510         


Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser 
        515                 520                 525             


Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg 
    530                 535                 540                 


Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr 
545                 550                 555                 560 


Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala 
                565                 570                 575     


Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala 
            580                 585                 590         


Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr Thr Met Arg Ser Pro 
        595                 600                 605             


Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Thr Leu Thr His Pro 
    610                 615                 620                 


Ile Thr Lys Ile Asp Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp 
625                 630                 635                 640 


Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala 
                645                 650                 655     


Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val Ile Val Gly 
            660                 665                 670         


Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp Arg Glu Val 
        675                 680                 685             


Leu Tyr 
    690 


<210>  29
<211>  694
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  29

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Lys Cys Tyr Phe Leu 
            260                 265                 270         


Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro Ala 
        275                 280                 285             


Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn Met 
    290                 295                 300                 


Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His Ala 
305                 310                 315                 320 


Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val Gln 
                325                 330                 335     


Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu Gly 
            340                 345                 350         


Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val Pro 
        355                 360                 365             


Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp Gly 
    370                 375                 380                 


Thr Ser Gly Gly Gly Ser Asp Glu Met Glu Glu Cys Ser Gln His Leu 
385                 390                 395                 400 


Pro Gly Ala Gly Ser Ser Gly Asp Ile Met Asp Tyr Lys Asp Asp Asp 
                405                 410                 415     


Asp Lys Gly Ser Ser Gly Thr Gly Ser Gly Ser Gly Thr Ser Ala Pro 
            420                 425                 430         


Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile 
        435                 440                 445             


Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln 
    450                 455                 460                 


Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly 
465                 470                 475                 480 


Val Cys Trp Ala Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser 
                485                 490                 495     


Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln Asp Leu 
            500                 505                 510         


Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr 
        515                 520                 525             


Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile 
    530                 535                 540                 


Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg 
545                 550                 555                 560 


Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro 
                565                 570                 575     


Ala Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly 
            580                 585                 590         


Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr Thr 
        595                 600                 605             


Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Thr 
    610                 615                 620                 


Leu Thr His Pro Ile Thr Lys Ile Asp Thr Lys Tyr Ile Met Thr Cys 
625                 630                 635                 640 


Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly 
                645                 650                 655     


Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val 
            660                 665                 670         


Val Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro 
        675                 680                 685             


Asp Arg Glu Val Leu Tyr 
    690                 


<210>  30
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  30

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Lys Arg Lys Gly Arg 
            260                 265                 270         


Cys Ser Val Pro Ala Phe Cys Ser Ser Gln Ala Glu Ala Pro Ala Asp 
        275                 280                 285             


Thr Pro Glu Pro Thr Ala Gly His Thr Leu Tyr Ser Val Leu Ser Gln 
    290                 295                 300                 


Gly Tyr Glu Lys Leu Asp Thr Pro Leu Arg Pro Ala Arg Gln Gln Pro 
305                 310                 315                 320 


Thr Pro Thr Ser Asp Ser Ser Ser Asp Ser Asn Leu Thr Thr Glu Glu 
                325                 330                 335     


Asp Glu Asp Arg Pro Glu Val His Lys Pro Ile Ser Gly Arg Tyr Glu 
            340                 345                 350         


Val Phe Asp Gln Val Thr Gln Glu Gly Ala Gly His Asp Pro Ala Pro 
        355                 360                 365             


Glu Gly Gln Ala Asp Tyr Asp Pro Val Thr Pro Tyr Val Thr Glu Val 
    370                 375                 380                 


Glu Ser Val Val Gly Glu Asn Thr Met Tyr Ala Gln Val Phe Asn Leu 
385                 390                 395                 400 


Gln Gly Lys Thr Pro Val Ser Gln Lys Glu Glu Ser Ser Ala Thr Ile 
                405                 410                 415     


Tyr Cys Ser Ile Arg Lys Pro Gln Val Val Pro Pro Pro Gln Gln Asn 
            420                 425                 430         


Asp Leu Glu Ile Pro Glu Ser Pro Thr Tyr Glu Asn Phe Thr Ser Gly 
        435                 440                 445             


Gly Gly Ser Asp Glu Met Glu Glu Cys Ser Gln His Leu Pro Gly Ala 
    450                 455                 460                 


Gly Ser Ser Gly Asp Ile Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
465                 470                 475                 480 


Ser Ser Gly Thr Gly Ser Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala 
                485                 490                 495     


Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu 
            500                 505                 510         


Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser 
        515                 520                 525             


Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp 
    530                 535                 540                 


Ala Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly 
545                 550                 555                 560 


Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp 
                565                 570                 575     


Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser 
            580                 585                 590         


Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg 
        595                 600                 605             


Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser 
    610                 615                 620                 


Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala Gly His 
625                 630                 635                 640 


Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys 
                645                 650                 655     


Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr Thr Met Arg Ser 
            660                 665                 670         


Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Thr Leu Thr His 
        675                 680                 685             


Pro Ile Thr Lys Ile Asp Thr Lys Tyr Ile Met Thr Cys Met Ser Ala 
    690                 695                 700                 


Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu 
705                 710                 715                 720 


Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val Ile Val 
                725                 730                 735     


Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp Arg Glu 
            740                 745                 750         


Val Leu Tyr 
        755 


<210>  31
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  31

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
    370                 375                 380                 


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
385                 390                 395                 400 


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
                405                 410                 415     


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
            420                 425                 430         


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
        435                 440                 445             


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
    450                 455                 460                 


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
465                 470                 475     


<210>  32
<211>  696
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  32

Met Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe 
1               5                   10                  15      


Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly 
            20                  25                  30          


Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu 
        35                  40                  45              


Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr 
    50                  55                  60                  


Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg 
65                  70                  75                  80  


Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser 
                85                  90                  95      


Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly 
            100                 105                 110         


Val Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile 
        115                 120                 125             


Arg Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu 
    130                 135                 140                 


Gln Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr 
145                 150                 155                 160 


Thr Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu 
                165                 170                 175     


Glu Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe 
            180                 185                 190         


Leu Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu 
        195                 200                 205             


His Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly 
    210                 215                 220                 


Lys Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu 
225                 230                 235                 240 


Val Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr 
                245                 250                 255     


Val Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly 
            260                 265                 270         


Arg Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly 
        275                 280                 285             


Gly Ser Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr 
    290                 295                 300                 


Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val 
305                 310                 315                 320 


Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro 
                325                 330                 335     


Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe 
            340                 345                 350         


Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp 
        355                 360                 365             


Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser 
    370                 375                 380                 


Trp Pro Leu Ser Gly Gly Gly Ser Asp Glu Met Glu Glu Cys Ser Gln 
385                 390                 395                 400 


His Leu Pro Gly Ala Gly Ser Ser Gly Asp Ile Met Asp Tyr Lys Asp 
                405                 410                 415     


Asp Asp Asp Lys Gly Ser Ser Gly Thr Gly Ser Gly Ser Gly Thr Ser 
            420                 425                 430         


Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys 
        435                 440                 445             


Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
    450                 455                 460                 


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile 
465                 470                 475                 480 


Asn Gly Val Cys Trp Ala Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
                485                 490                 495     


Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln 
            500                 505                 510         


Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
        515                 520                 525             


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
    530                 535                 540                 


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
545                 550                 555                 560 


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
                565                 570                 575     


Cys Pro Ala Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr 
            580                 585                 590         


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu 
        595                 600                 605             


Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala 
    610                 615                 620                 


Val Thr Leu Thr His Pro Ile Thr Lys Ile Asp Thr Lys Tyr Ile Met 
625                 630                 635                 640 


Thr Cys Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu 
                645                 650                 655     


Val Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly 
            660                 665                 670         


Cys Val Val Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile 
        675                 680                 685             


Ile Pro Asp Arg Glu Val Leu Tyr 
    690                 695     


<210>  33
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  33

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gly Gly 
                245                 250                 255     


Ser Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly 
            260                 265                 270         


Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp 
        275                 280                 285             


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro 
    290                 295                 300                 


Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
305                 310                 315                 320 


Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly 
                325                 330                 335     


Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp 
            340                 345                 350         


Pro Leu Ser Gly Gly Gly Ser Asp Glu Met Glu Glu Cys Ser Gln His 
        355                 360                 365             


Leu Pro Gly Ala Gly Ser Ser Gly Asp Ile Met Asp Tyr Lys Asp Asp 
    370                 375                 380                 


Asp Asp Lys Gly Ser Ser Gly Thr Gly Ser Gly Ser Gly Thr Ser Ala 
385                 390                 395                 400 


Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile 
                405                 410                 415     


Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
            420                 425                 430         


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile Asn 
        435                 440                 445             


Gly Val Cys Trp Ala Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
    450                 455                 460                 


Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln Asp 
465                 470                 475                 480 


Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
                485                 490                 495     


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
            500                 505                 510         


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
        515                 520                 525             


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys 
    530                 535                 540                 


Pro Ala Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg 
545                 550                 555                 560 


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr 
                565                 570                 575     


Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val 
            580                 585                 590         


Thr Leu Thr His Pro Ile Thr Lys Ile Asp Thr Lys Tyr Ile Met Thr 
        595                 600                 605             


Cys Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val 
    610                 615                 620                 


Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys 
625                 630                 635                 640 


Val Val Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile 
                645                 650                 655     


Pro Asp Arg Glu Val Leu Tyr 
            660             


<210>  34
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric

<400>  34

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ser Gly Gly Gly Ser Asp Glu Met 
            260                 265                 270         


Glu Glu Cys Ser Gln His Leu Pro Gly Ala Gly Ser Ser Gly Asp Ile 
        275                 280                 285             


Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ser Gly Thr Gly Ser 
    290                 295                 300                 


Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg 
305                 310                 315                 320 


Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn 
                325                 330                 335     


Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe 
            340                 345                 350         


Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Ala Val Tyr His Gly Ala 
        355                 360                 365             


Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr 
    370                 375                 380                 


Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ser 
385                 390                 395                 400 


Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val 
                405                 410                 415     


Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg 
            420                 425                 430         


Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser 
        435                 440                 445             


Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Leu Phe Arg 
    450                 455                 460                 


Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro 
465                 470                 475                 480 


Val Glu Asn Leu Glu Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn 
                485                 490                 495     


Ser Ser Pro Pro Ala Val Thr Leu Thr His Pro Ile Thr Lys Ile Asp 
            500                 505                 510         


Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val Val Thr 
        515                 520                 525             


Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr 
    530                 535                 540                 


Cys Leu Ser Thr Gly Cys Val Val Ile Val Gly Arg Ile Val Leu Ser 
545                 550                 555                 560 


Gly Lys Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr 
                565                 570             


<210>  35
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial

<400>  35

Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210>  36
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artifical

<400>  36

Met Ala Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile 
1               5                   10                  15      


Ser Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp 
            20                  25                  30          


Gly Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val 
        35                  40                  45              


Leu Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg 
    50                  55                  60                  


Gln Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly 
65                  70                  75                  80  


Pro Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro 
                85                  90                  95      


Cys Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln 
            100                 105                 110         


Pro Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val 
        115                 120                 125             


Arg Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile 
    130                 135                 140                 


Ser Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu 
145                 150                 155                 160 


Arg Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg 
                165                 170                 175     


Lys Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro 
            180                 185                 190         


Arg Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr 
        195                 200                 205             


Val Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile 
    210                 215                 220                 


Pro Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu 
225                 230                 235                 240 


Lys Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro 
                245                 250                 255     


Asn Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala 
            260                 265                 270         


Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu 
        275                 280                 285             


Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp 
    290                 295                 300                 


Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro 
305                 310                 315                 320 


Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr 
                325                 330                 335     


Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln 
            340                 345                 350         


Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly 
        355                 360                 365             


Gly Ser Asp Glu Met Glu Glu Cys Ser Gln His Leu Pro Gly Ala Gly 
    370                 375                 380                 


Ser Ser Gly Asp Ile Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser 
385                 390                 395                 400 


Ser Gly Thr Gly Ser Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala Tyr 
                405                 410                 415     


Ala Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr 
            420                 425                 430         


Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr 
        435                 440                 445             


Ala Thr Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Ala 
    450                 455                 460                 


Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro 
465                 470                 475                 480 


Val Ile Gln Met Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro 
                485                 490                 495     


Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser 
            500                 505                 510         


Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg 
        515                 520                 525             


Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr 
    530                 535                 540                 


Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala 
545                 550                 555                 560 


Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala 
                565                 570                 575     


Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr Thr Met Arg Ser Pro 
            580                 585                 590         


Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Thr Leu Thr His Pro 
        595                 600                 605             


Ile Thr Lys Ile Asp Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp 
    610                 615                 620                 


Leu Glu Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala 
625                 630                 635                 640 


Ala Leu Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val Ile Val Gly 
                645                 650                 655     


Arg Ile Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp Arg Glu Val 
            660                 665                 670         


Leu Tyr 
        


<210>  37
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  37

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  38
<211>  635
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  38

Met Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe 
1               5                   10                  15      


Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly 
            20                  25                  30          


Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu 
        35                  40                  45              


Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr 
    50                  55                  60                  


Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg 
65                  70                  75                  80  


Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser 
                85                  90                  95      


Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly 
            100                 105                 110         


Val Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile 
        115                 120                 125             


Arg Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu 
    130                 135                 140                 


Gln Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr 
145                 150                 155                 160 


Thr Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu 
                165                 170                 175     


Glu Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe 
            180                 185                 190         


Leu Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu 
        195                 200                 205             


His Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly 
    210                 215                 220                 


Lys Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu 
225                 230                 235                 240 


Val Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr 
                245                 250                 255     


Val Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly 
            260                 265                 270         


Arg Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly 
        275                 280                 285             


Ile Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys Pro Gly His Arg 
    290                 295                 300                 


Lys Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser Thr Val Ser Phe 
305                 310                 315                 320 


Asn Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro 
                325                 330                 335     


Gln Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr 
            340                 345                 350         


Ala Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys 
        355                 360                 365             


Leu Leu Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr 
    370                 375                 380                 


Val Lys Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala 
385                 390                 395                 400 


Val Lys Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu 
                405                 410                 415     


Leu Leu Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile 
            420                 425                 430         


Val Arg Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met 
        435                 440                 445             


Glu Met Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg 
    450                 455                 460                 


His Val Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met 
465                 470                 475                 480 


Gly Met Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala 
                485                 490                 495     


Ala Arg Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp 
            500                 505                 510         


Phe Gly Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala 
        515                 520                 525             


Gln Thr His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile 
    530                 535                 540                 


Asn Tyr Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val 
545                 550                 555                 560 


Leu Met Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met 
                565                 570                 575     


Lys Gly Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly 
            580                 585                 590         


Cys Pro Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys 
        595                 600                 605             


Trp Thr Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu 
    610                 615                 620                 


Arg Leu Arg Asn Tyr Tyr Tyr Asp Val Val Asn 
625                 630                 635 


<210>  39
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artifical

<400>  39

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  40
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial

<400>  40

Asp Glu Met Glu Glu Cys Ser Gln His Leu Pro Gly Ala Gly Ser Ser 
1               5                   10                  15      


Gly Asp Ile Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Ser Gly 
            20                  25                  30          


Thr Gly Ser Gly Ser Gly Thr Ser Ala Pro Ile Thr Ala Tyr Ala Gln 
        35                  40                  45              


Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg 
    50                  55                  60                  


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr 
65                  70                  75                  80  


Gln Thr Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Ala Val Tyr 
                85                  90                  95      


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Ile 
            100                 105                 110         


Gln Met Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro Ala Pro 
        115                 120                 125             


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
    130                 135                 140                 


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
145                 150                 155                 160 


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
                165                 170                 175     


Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
            180                 185                 190         


Leu Phe Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp 
        195                 200                 205             


Phe Ile Pro Val Glu Asn Leu Glu Thr Thr Met Arg Ser Pro Val Phe 
    210                 215                 220                 


Thr Asp Asn Ser Ser Pro Pro Ala Val Thr Leu Thr His Pro Ile Thr 
225                 230                 235                 240 


Lys Ile Asp Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp Leu Glu 
                245                 250                 255     


Val Val Thr Ser Thr Trp Val Leu Val Gly Gly Val Leu Ala Ala Leu 
            260                 265                 270         


Ala Ala Tyr Cys Leu Ser Thr Gly Cys Val Val Ile Val Gly Arg Ile 
        275                 280                 285             


Val Leu Ser Gly Lys Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr 
    290                 295                 300                 


<210>  41
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IKZF1 ZF2-3

<400>  41

Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
            20                  25                  30          


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
        35                  40                  45              


Arg Thr His 
    50      


<210>  42
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  42

<400>  42

Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys His 
            20                  25                  30          


Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His Leu 
        35                  40                  45              


Arg Thr His 
    50      


<210>  43
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  43

<400>  43

Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu 
1               5                   10                  15      


Asn Trp His Met Lys Lys His Asp Ala Asp Ser Phe Tyr Gln Phe Ser 
            20                  25                  30          


Cys Asn Ile Cys Gly Lys Lys Phe Glu Lys Lys Asp Ser Val Val Ala 
        35                  40                  45              


His Lys Ala Lys Ser His 
    50                  


<210>  44
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  44

<400>  44

Leu Gln Cys Glu Val Cys Gly Phe Gln Cys Arg Gln Arg Ala Ser Leu 
1               5                   10                  15      


Lys Tyr His Met Thr Lys His Lys Ala Glu Thr Glu Leu Asp Phe Ala 
            20                  25                  30          


Cys Asp Gln Cys Gly Arg Arg Phe Glu Lys Ala His Asn Leu Asn Val 
        35                  40                  45              


His Met Ser Met Val His 
    50                  


<210>  45
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  45

<400>  45

Leu Gln Cys Glu Ile Cys Gly Tyr Gln Cys Arg Gln Arg Ala Ser Leu 
1               5                   10                  15      


Asn Trp His Met Lys Lys His Thr Ala Glu Val Gln Tyr Asn Phe Thr 
            20                  25                  30          


Cys Asp Arg Cys Gly Lys Arg Phe Glu Lys Leu Asp Ser Val Lys Phe 
        35                  40                  45              


His Thr Leu Lys Ser His 
    50                  


<210>  46
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  46

<400>  46

Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Ala Ser Leu 
1               5                   10                  15      


Asn Trp His Gln Arg Lys His Ala Glu Thr Val Ala Ala Leu Arg Phe 
            20                  25                  30          


Pro Cys Glu Phe Cys Gly Lys Arg Phe Glu Lys Pro Asp Ser Val Ala 
        35                  40                  45              


Ala His Arg Ser Lys Ser His 
    50                  55  


<210>  47
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  47

<400>  47

Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
            20                  25                  30          


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
        35                  40                  45              


Arg Thr His 
    50      


<210>  48
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  48

<400>  48

Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His 
            20              


<210>  49
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  49

<400>  49

Leu Gln Cys Glu Ile Cys Gly Tyr Gln Cys Arg Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
            20                  25                  30          


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
        35                  40                  45              


Arg Thr His 
    50      


<210>  50
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  50

<400>  50

Leu Gln Cys Glu Val Cys Gly Phe Gln Cys Arg Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
            20                  25                  30          


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
        35                  40                  45              


Arg Thr His 
    50      


<210>  51
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51

<400>  51

Phe Gln Cys Pro Ile Cys Gly Leu Val Ile Lys Gln Lys Gly Asn Leu 
1               5                   10                  15      


Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His 
            20                  25                  30          


Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu 
        35                  40                  45              


Arg Thr His 
    50      


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  52

<400>  52

Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg 
1               5                   10      


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  53

<400>  53

Leu Gln Cys Glu Ile Cys Gly Tyr Gln Cys Arg 
1               5                   10      


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54

<400>  54

Leu Gln Cys Glu Val Cys Gly Phe Gln Cys Arg 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  55

<400>  55

Phe Gln Cys Pro Ile Cys Gly Leu Val Ile Lys 
1               5                   10      


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  56

<400>  56

Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His 
1               5                   10          


<210>  57
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  57

<400>  57

Phe Lys Cys His Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu 
1               5                   10                  15      


Thr Gly His Leu Arg Thr His 
            20              


<210>  58
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  58

<400>  58

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Arg Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr 
    370                 375                 380                 


Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys 
385                 390                 395                 400 


Pro Phe Lys Cys His Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala 
                405                 410                 415     


Leu Thr Gly His Leu Arg Thr His Ser Val 
            420                 425     


<210>  59
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  59

<400>  59

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Arg Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr 
    370                 375                 380                 


Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Phe Lys Cys His Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala 
                405                 410                 415     


Leu Thr Gly His Leu Arg Thr His Ser Val 
            420                 425     


<210>  60
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  60

<400>  60

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Lys Pro Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg 
    370                 375                 380                 


Gln Lys Ala Ser Leu Asn Trp His Met Lys Lys His Asp Ala Asp Ser 
385                 390                 395                 400 


Phe Tyr Gln Phe Ser Cys Asn Ile Cys Gly Lys Lys Phe Glu Lys Lys 
                405                 410                 415     


Asp Ser Val Val Ala His Lys Ala Lys Ser His Pro Glu 
            420                 425                 


<210>  61
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  61

<400>  61

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Ala Lys Pro Leu Gln Cys Glu Val Cys Gly Phe Gln Cys Arg 
    370                 375                 380                 


Gln Arg Ala Ser Leu Lys Tyr His Met Thr Lys His Lys Ala Glu Thr 
385                 390                 395                 400 


Glu Leu Asp Phe Ala Cys Asp Gln Cys Gly Arg Arg Phe Glu Lys Ala 
                405                 410                 415     


His Asn Leu Asn Val His Met Ser Met Val His Pro Leu 
            420                 425                 


<210>  62
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62

<400>  62

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Thr Pro Leu Gln Cys Glu Ile Cys Gly Tyr Gln Cys Arg 
    370                 375                 380                 


Gln Arg Ala Ser Leu Asn Trp His Met Lys Lys His Thr Ala Glu Val 
385                 390                 395                 400 


Gln Tyr Asn Phe Thr Cys Asp Arg Cys Gly Lys Arg Phe Glu Lys Leu 
                405                 410                 415     


Asp Ser Val Lys Phe His Thr Leu Lys Ser His Pro Asp 
            420                 425                 


<210>  63
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  63

<400>  63

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Lys Pro Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg 
    370                 375                 380                 


Gln Lys Ala Ser Leu Asn Trp His Gln Arg Lys His Ala Glu Thr Val 
385                 390                 395                 400 


Ala Ala Leu Arg Phe Pro Cys Glu Phe Cys Gly Lys Arg Phe Glu Lys 
                405                 410                 415     


Pro Asp Ser Val Ala Ala His Arg Ser Lys Ser His Pro Ala 
            420                 425                 430 


<210>  64
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  64

<400>  64

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Arg Pro Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg 
    370                 375                 380                 


Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His Ser Gly 
385                 390                 395             


<210>  65
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  65

<400>  65

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Arg Pro Leu Gln Cys Glu Ile Cys Gly Tyr Gln Cys Arg 
    370                 375                 380                 


Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys 
385                 390                 395                 400 


Pro Phe Lys Cys His Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala 
                405                 410                 415     


Leu Thr Gly His Leu Arg Thr His Ser Val 
            420                 425     


<210>  66
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  66

<400>  66

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Arg Pro Leu Gln Cys Glu Ile Cys Gly Phe Thr Cys Arg 
    370                 375                 380                 


Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys 
385                 390                 395                 400 


Pro Phe Lys Cys His Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala 
                405                 410                 415     


Leu Thr Gly His Leu Arg Thr His Ser Val 
            420                 425     


<210>  67
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  67

<400>  67

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Arg Pro Leu Gln Cys Glu Val Cys Gly Phe Gln Cys Arg 
    370                 375                 380                 


Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys 
385                 390                 395                 400 


Pro Phe Lys Cys His Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala 
                405                 410                 415     


Leu Thr Gly His Leu Arg Thr His Ser Val 
            420                 425     


<210>  68
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  68

<400>  68

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Gly Gly Ser Cys Ser Arg Ala Ala 
            260                 265                 270         


Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp 
        275                 280                 285             


Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe 
    290                 295                 300                 


Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu 
305                 310                 315                 320 


Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser 
                325                 330                 335     


Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro 
            340                 345                 350         


Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu Ser Gly Gly Gly 
        355                 360                 365             


Ser Gly Glu Arg Pro Phe Gln Cys Pro Ile Cys Gly Leu Val Ile Lys 
    370                 375                 380                 


Gln Lys Gly Asn Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys 
385                 390                 395                 400 


Pro Phe Lys Cys His Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala 
                405                 410                 415     


Leu Thr Gly His Leu Arg Thr His Ser Val 
            420                 425     


