                         SEQUENCE LISTING

<110>  NovaGo Therapeutics AG
 
<120>  Novel anti-Nogo-A antibodies

<130>  NO48A05/P-WO

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(360)
<223>  NG004 variable heavy chain (VH) sequence

<400>  1
gag gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc agg agc cat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His           
            20                  25                  30                    

gct atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca gtt aca tca tat gat gga acc aat aaa tac tac gca gac tcc gtg        192
Ala Val Thr Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aaa gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg gac agc ctc aga gtt gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asp Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg aga ggc cga gca gtg gct ggt acg agg gaa gat tat tgg ggc cag        336
Ala Arg Gly Arg Ala Val Ala Gly Thr Arg Glu Asp Tyr Trp Gly Gln           
            100                 105                 110                   

gga acc ctg gtc acc gtc tcc tcg                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  2
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Thr Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ala Val Ala Gly Thr Arg Glu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser His Ala Met His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Thr Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Arg Ala Val Ala Gly Thr Arg Glu Asp Tyr 
1               5                   10      


<210>  6
<211>  339
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(339)
<223>  NG004 variable kappa chain (VK) sequence

<400>  6
gac atc cag atg acc cag tct cca gac tcc ctg gct gtg tct ctg ggc         48
Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

gag agg gcc acc atc aac tgc aag tcc agc cag agt gtt tta ttc agc         96
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser           
            20                  25                  30                    

tcc aac agt aag aac tac tta gct tgg tac cag cag aaa cca gga cag        144
Ser Asn Ser Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln           
        35                  40                  45                        

cct cct aag gtg ctc att tac tgg gca tct acc cgg gaa tcc ggg gtc        192
Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val           
    50                  55                  60                            

cct gac cga ttc agt ggc agc ggg tct ggg aca gat ttc act ctc acc        240
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr           
65                  70                  75                  80            

atc agc agc ctg cag gct gaa gat gtg gca gtt tat tac tgt cag caa        288
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln           
                85                  90                  95                

tat tat act act cgc cct acg ttc ggc cta ggg acc aaa gtg gat atc        336
Tyr Tyr Thr Thr Arg Pro Thr Phe Gly Leu Gly Thr Lys Val Asp Ile           
            100                 105                 110                   

aaa                                                                    339
Lys                                                                       
                                                                          


<210>  7
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Phe Ser 
            20                  25                  30          


Ser Asn Ser Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Thr Arg Pro Thr Phe Gly Leu Gly Thr Lys Val Asp Ile 
            100                 105                 110         


Lys 
    


<210>  8
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Ser Ser Gln Ser Val Leu Phe Ser Ser Asn Ser Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Gln Tyr Tyr Thr Thr Arg Pro Thr 
1               5                   


<210>  11
<211>  342
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(342)
<223>  NG034 variable heavy chain (VH) sequence

<400>  11
gag gtg cag ctg gtg gag act ggg gga ggc ttg gtc cca ccg ggg ggg         48
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Pro Pro Gly Gly           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc acc aac tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr           
            20                  25                  30                    

tct atg cac tgg gtc cgc ctg gct cca ggg aag aga ctg gaa tat att        144
Ser Met His Trp Val Arg Leu Ala Pro Gly Lys Arg Leu Glu Tyr Ile           
        35                  40                  45                        

tca gct att agt agt gat ggc ggt gac cca ttt tat gca agc tct gtg        192
Ser Ala Ile Ser Ser Asp Gly Gly Asp Pro Phe Tyr Ala Ser Ser Val           
    50                  55                  60                            

aag ggc aga gtc gcc atc tcc aga gac aat tcc aag aag acg ttg tat        240
Lys Gly Arg Val Ala Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Tyr           
65                  70                  75                  80            

ctt caa atg ggc aga ctg aga cct gag gac acg gct gta tat tat tgt        288
Leu Gln Met Gly Arg Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gtg agt gat gct ttt gat gtc tgg ggc cag ggg aca atg gtc acc gtc        336
Val Ser Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val           
            100                 105                 110                   

tct tcg                                                                342
Ser Ser                                                                   
                                                                          


<210>  12
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Pro Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ser Met His Trp Val Arg Leu Ala Pro Gly Lys Arg Leu Glu Tyr Ile 
        35                  40                  45              


Ser Ala Ile Ser Ser Asp Gly Gly Asp Pro Phe Tyr Ala Ser Ser Val 
    50                  55                  60                  


Lys Gly Arg Val Ala Ile Ser Arg Asp Asn Ser Lys Lys Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Arg Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  13
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  13

Asn Tyr Ser Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Ile Ser Ser Asp Gly Gly Asp Pro Phe Tyr Ala Ser Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  15

Asp Ala Phe Asp Val 
1               5   


<210>  16
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)
<223>  NG034 variable kappa chain (VK) sequence

<400>  16
gaa att gtg ctg acc cag tct cca ctc tcc ctg tcc gtc acc ctt gga         48
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly           
1               5                   10                  15                

cag ccg gcc tcc atc tcc tgc agg tct agt caa agc ctc cta tac agt         96
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser           
            20                  25                  30                    

aat ggc aac acc tac ttg aat tgg ttt cag cag agg cca ggc caa tct        144
Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser           
        35                  40                  45                        

cca agg cgc cta ctt tat agg gtt tct aac cgg gac tct ggg gtc cca        192
Pro Arg Arg Leu Leu Tyr Arg Val Ser Asn Arg Asp Ser Gly Val Pro           
    50                  55                  60                            

gac aga ttc agc ggc agt ggg tca ggc act cat ttc aca ctg aaa att        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Lys Ile           
65                  70                  75                  80            

agt agg gtg gag gct gag gat gtt gga gtt tat tac tgc atg caa ggt        288
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly           
                85                  90                  95                

aca cac tgg cct cgc acg ttc ggc caa ggg acc aag gtg gag atc aaa        336
Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys           
            100                 105                 110                   


<210>  17
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Leu Tyr Arg Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr His Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  18
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Val Ser Asn Arg Asp Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gln Gly Thr His Trp Pro Arg Thr 
1               5                   


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  minimal epitope recognized by NG004


<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  minimal epitope recognized by antibody NG004

<400>  21

Ile Asn Ala Ala Leu Gln Glu 
1               5           


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 34


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Peptide 34: amino acods 133-147 of the Nogo-A d20plus region

<400>  22

Glu Glu Ile Lys Glu Pro Glu Asn Ile Asn Ala Ala Leu Gln Glu 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 35


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Peptide 35: amino acids 137-151 of the Nogo-A d20plus region

<400>  23

Glu Pro Glu Asn Ile Asn Ala Ala Leu Gln Glu Thr Glu Ala Pro 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide 36


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Peptide 36: amino acids 141-155 of the Nogo-A d20plus region

<400>  24

Ile Asn Ala Ala Leu Gln Glu Thr Glu Ala Pro Tyr Ile Ser Ile 
1               5                   10                  15  


