               SEQUENCE LISTING

<110> GAMAMABS PHARMA

<120> AMH-COMPETITIVE ANTAGONIST ANTIBODY

<130> PR83978

<160> 12

<170> BiSSAP 1.3.6

<210> 1
<211> 451
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence of heavy chain

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Asn 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ser Tyr Ile Ser Gly Ser Ser Arg Tyr Ile Ser Tyr Ala Asp Phe Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Ser Ser Asp Asp Tyr Phe Gly Gly Gly Met Asp Val Trp Gly 
            100                 105                 110         
Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             
Pro Gly Lys 
    450     

<210> 2
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence of heavy chain variable region

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Ser Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Asn 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Ser Tyr Ile Ser Gly Ser Ser Arg Tyr Ile Ser Tyr Ala Asp Phe Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Arg Ser Ser Asp Asp Tyr Phe Gly Gly Gly Met Asp Val Trp Gly 
            100                 105                 110         
Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 3
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> H-CDR1

<400> 3
Gly Phe Thr Phe Ser Asn Asn Ala Met Asn 
1               5                   10  

<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> H-CDR2

<400> 4
Tyr Ile Ser Gly Ser Ser Arg Tyr Ile Ser 
1               5                   10  

<210> 5
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> H-CDR3

<400> 5
Ser Ser Asp Asp Tyr Phe Gly Gly Gly Met Asp Val 
1               5                   10          

<210> 6
<211> 216
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence of the light chain

<400> 6
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Gly Asp 
            20                  25                  30          
Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Tyr Asp Ser Tyr Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Ser Thr Tyr Tyr 
                85                  90                  95      
Ser Thr Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         
Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             
Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 
Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 
Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     
Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         
Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             
Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     

<210> 7
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> amino acid sequence of the light chain variable region

<400> 7
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Ala Gly Thr Ser Ser Asp Val Gly Gly Asp 
            20                  25                  30          
Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Tyr Asp Ser Tyr Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Ser Thr Tyr Tyr 
                85                  90                  95      
Ser Thr Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 

<210> 8
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-CDR1

<400> 8
Ala Gly Thr Ser Ser Asp Val Gly Gly Asp Asn Asp Val Ser 
1               5                   10                  

<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-CDR2

<400> 9
Tyr Asp Ser Tyr Arg Pro Ser 
1               5           

<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> L-CDR3

<400> 10
Ser Ser Ser Thr Tyr Tyr Ser Thr Arg Val 
1               5                   10  

<210> 11
<211> 556
<212> PRT
<213> Homo sapiens


<220> 
<223> human AMHR-II amino acid sequence devoid of its signal peptide

<400> 11
Pro Pro Asn Arg Arg Thr Cys Val Phe Phe Glu Ala Pro Gly Val Arg 
1               5                   10                  15      
Gly Ser Thr Lys Thr Leu Gly Glu Leu Leu Asp Thr Gly Thr Glu Leu 
            20                  25                  30          
Pro Arg Ala Ile Arg Cys Leu Tyr Ser Arg Cys Cys Phe Gly Ile Trp 
        35                  40                  45              
Asn Leu Thr Gln Asp Arg Ala Gln Val Glu Met Gln Gly Cys Arg Asp 
    50                  55                  60                  
Ser Asp Glu Pro Gly Cys Glu Ser Leu His Cys Asp Pro Ser Pro Arg 
65                  70                  75                  80  
Ala His Pro Ser Pro Gly Ser Thr Leu Phe Thr Cys Ser Cys Gly Thr 
                85                  90                  95      
Asp Phe Cys Asn Ala Asn Tyr Ser His Leu Pro Pro Pro Gly Ser Pro 
            100                 105                 110         
Gly Thr Pro Gly Ser Gln Gly Pro Gln Ala Ala Pro Gly Glu Ser Ile 
        115                 120                 125             
Trp Met Ala Leu Val Leu Leu Gly Leu Phe Leu Leu Leu Leu Leu Leu 
    130                 135                 140                 
Leu Gly Ser Ile Ile Leu Ala Leu Leu Gln Arg Lys Asn Tyr Arg Val 
145                 150                 155                 160 
Arg Gly Glu Pro Val Pro Glu Pro Arg Pro Asp Ser Gly Arg Asp Trp 
                165                 170                 175     
Ser Val Glu Leu Gln Glu Leu Pro Glu Leu Cys Phe Ser Gln Val Ile 
            180                 185                 190         
Arg Glu Gly Gly His Ala Val Val Trp Ala Gly Gln Leu Gln Gly Lys 
        195                 200                 205             
Leu Val Ala Ile Lys Ala Phe Pro Pro Arg Ser Val Ala Gln Phe Gln 
    210                 215                 220                 
Ala Glu Arg Ala Leu Tyr Glu Leu Pro Gly Leu Gln His Asp His Ile 
225                 230                 235                 240 
Val Arg Phe Ile Thr Ala Ser Arg Gly Gly Pro Gly Arg Leu Leu Ser 
                245                 250                 255     
Gly Pro Leu Leu Val Leu Glu Leu His Pro Lys Gly Ser Leu Cys His 
            260                 265                 270         
Tyr Leu Thr Gln Tyr Thr Ser Asp Trp Gly Ser Ser Leu Arg Met Ala 
        275                 280                 285             
Leu Ser Leu Ala Gln Gly Leu Ala Phe Leu His Glu Glu Arg Trp Gln 
    290                 295                 300                 
Asn Gly Gln Tyr Lys Pro Gly Ile Ala His Arg Asp Leu Ser Ser Gln 
305                 310                 315                 320 
Asn Val Leu Ile Arg Glu Asp Gly Ser Cys Ala Ile Gly Asp Leu Gly 
                325                 330                 335     
Leu Ala Leu Val Leu Pro Gly Leu Thr Gln Pro Pro Ala Trp Thr Pro 
            340                 345                 350         
Thr Gln Pro Gln Gly Pro Ala Ala Ile Met Glu Ala Gly Thr Gln Arg 
        355                 360                 365             
Tyr Met Ala Pro Glu Leu Leu Asp Lys Thr Leu Asp Leu Gln Asp Trp 
    370                 375                 380                 
Gly Met Ala Leu Arg Arg Ala Asp Ile Tyr Ser Leu Ala Leu Leu Leu 
385                 390                 395                 400 
Trp Glu Ile Leu Ser Arg Cys Pro Asp Leu Arg Pro Asp Ser Ser Pro 
                405                 410                 415     
Pro Pro Phe Gln Leu Ala Tyr Glu Ala Glu Leu Gly Asn Thr Pro Thr 
            420                 425                 430         
Ser Asp Glu Leu Trp Ala Leu Ala Val Gln Glu Arg Arg Arg Pro Tyr 
        435                 440                 445             
Ile Pro Ser Thr Trp Arg Cys Phe Ala Thr Asp Pro Asp Gly Leu Arg 
    450                 455                 460                 
Glu Leu Leu Glu Asp Cys Trp Asp Ala Asp Pro Glu Ala Arg Leu Thr 
465                 470                 475                 480 
Ala Glu Cys Val Gln Gln Arg Leu Ala Ala Leu Ala His Pro Gln Glu 
                485                 490                 495     
Ser His Pro Phe Pro Glu Ser Cys Pro Arg Gly Cys Pro Pro Leu Cys 
            500                 505                 510         
Pro Glu Asp Cys Thr Ser Ile Pro Ala Pro Thr Ile Leu Pro Cys Arg 
        515                 520                 525             
Pro Gln Arg Ser Ala Cys His Phe Ser Val Gln Gln Gly Pro Cys Ser 
    530                 535                 540                 
Arg Asn Pro Gln Pro Ala Cys Thr Leu Ser Pro Val 
545                 550                 555     

<210> 12
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> amino acid of the signal peptide of the human AMHR-II

<400> 12
Met Leu Gly Ser Leu Gly Leu Trp Ala Leu Leu Pro Thr Ala Val Glu 
1               5                   10                  15      
Ala 
    

