                         SEQUENCE LISTING

<110>  GENETHON ET AL
 
<120>  CHIMERIC POLYPEPTIDES AND USES THEREOF

<130>  B3127PC00

<160>  69    

<170>  PatentIn version 3.3

<210>  1
<211>  2859
<212>  DNA
<213>  Homo sapiens

<400>  1
atgggagtga ggcacccgcc ctgctcccac cggctcctgg ccgtctgcgc cctcgtgtcc     60

ttggcaaccg ctgcactcct ggggcacatc ctactccatg atttcctgct ggttccccga    120

gagctgagtg gctcctcccc agtcctggag gagactcacc cagctcacca gcagggagcc    180

agcagaccag ggccccggga tgcccaggca caccccggcc gtcccagagc agtgcccaca    240

cagtgcgacg tcccccccaa cagccgcttc gattgcgccc ctgacaaggc catcacccag    300

gaacagtgcg aggcccgcgg ctgctgctac atccctgcaa agcaggggct gcagggagcc    360

cagatggggc agccctggtg cttcttccca cccagctacc ccagctacaa gctggagaac    420

ctgagctcct ctgaaatggg ctacacggcc accctgaccc gtaccacccc caccttcttc    480

cccaaggaca tcctgaccct gcggctggac gtgatgatgg agactgagaa ccgcctccac    540

ttcacgatca aagatccagc taacaggcgc tacgaggtgc ccttggagac cccgcgtgtc    600

cacagccggg caccgtcccc actctacagc gtggagttct ccgaggagcc cttcggggtg    660

atcgtgcacc ggcagctgga cggccgcgtg ctgctgaaca cgacggtggc gcccctgttc    720

tttgcggacc agttccttca gctgtccacc tcgctgccct cgcagtatat cacaggcctc    780

gccgagcacc tcagtcccct gatgctcagc accagctgga ccaggatcac cctgtggaac    840

cgggaccttg cgcccacgcc cggtgcgaac ctctacgggt ctcacccttt ctacctggcg    900

ctggaggacg gcgggtcggc acacggggtg ttcctgctaa acagcaatgc catggatgtg    960

gtcctgcagc cgagccctgc ccttagctgg aggtcgacag gtgggatcct ggatgtctac   1020

atcttcctgg gcccagagcc caagagcgtg gtgcagcagt acctggacgt tgtgggatac   1080

ccgttcatgc cgccatactg gggcctgggc ttccacctgt gccgctgggg ctactcctcc   1140

accgctatca cccgccaggt ggtggagaac atgaccaggg cccacttccc cctggacgtc   1200

caatggaacg acctggacta catggactcc cggagggact tcacgttcaa caaggatggc   1260

ttccgggact tcccggccat ggtgcaggag ctgcaccagg gcggccggcg ctacatgatg   1320

atcgtggatc ctgccatcag cagctcgggc cctgccggga gctacaggcc ctacgacgag   1380

ggtctgcgga ggggggtttt catcaccaac gagaccggcc agccgctgat tgggaaggta   1440

tggcccgggt ccactgcctt ccccgacttc accaacccca cagccctggc ctggtgggag   1500

gacatggtgg ctgagttcca tgaccaggtg cccttcgacg gcatgtggat tgacatgaac   1560

gagccttcca acttcatcag aggctctgag gacggctgcc ccaacaatga gctggagaac   1620

ccaccctacg tgcctggggt ggttgggggg accctccagg cggccaccat ctgtgcctcc   1680

agccaccagt ttctctccac acactacaac ctgcacaacc tctacggcct gaccgaagcc   1740

atcgcctccc acagggcgct ggtgaaggct cgggggacac gcccatttgt gatctcccgc   1800

tcgacctttg ctggccacgg ccgatacgcc ggccactgga cgggggacgt gtggagctcc   1860

tgggagcagc tcgcctcctc cgtgccagaa atcctgcagt ttaacctgct gggggtgcct   1920

ctggtcgggg ccgacgtctg cggcttcctg ggcaacacct cagaggagct gtgtgtgcgc   1980

tggacccagc tgggggcctt ctaccccttc atgcggaacc acaacagcct gctcagtctg   2040

ccccaggagc cgtacagctt cagcgagccg gcccagcagg ccatgaggaa ggccctcacc   2100

ctgcgctacg cactcctccc ccacctctac acactgttcc accaggccca cgtcgcgggg   2160

gagaccgtgg cccggcccct cttcctggag ttccccaagg actctagcac ctggactgtg   2220

gaccaccagc tcctgtgggg ggaggccctg ctcatcaccc cagtgctcca ggccgggaag   2280

gccgaagtga ctggctactt ccccttgggc acatggtacg acctgcagac ggtgccaata   2340

gaggcccttg gcagcctccc acccccacct gcagctcccc gtgagccagc catccacagc   2400

gaggggcagt gggtgacgct gccggccccc ctggacacca tcaacgtcca cctccgggct   2460

gggtacatca tccccctgca gggccctggc ctcacaacca cagagtcccg ccagcagccc   2520

atggccctgg ctgtggccct gaccaagggt ggagaggccc gaggggagct gttctgggac   2580

gatggagaga gcctggaagt gctggagcga ggggcctaca cacaggtcat cttcctggcc   2640

aggaataaca cgatcgtgaa tgagctggta cgtgtgacca gtgagggagc tggcctgcag   2700

ctgcagaagg tgactgtcct gggcgtggcc acggcgcccc agcaggtcct ctccaacggt   2760

gtccctgtct ccaacttcac ctacagcccc gacaccaagg tcctggacat ctgtgtctcg   2820

ctgttgatgg gagagcagtt tctcgtcagc tggtgttag                          2859


<210>  2
<211>  2778
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco1 w/o sp

<400>  2
ggccatatcc tgctgcacga ctttctacta gtgcccagag agctgagcgg cagctctccc     60

gtgctggaag aaacacaccc tgcccatcag cagggcgcct ctagacctgg acctagagat    120

gcccaggccc accccggcag acctagagct gtgcctaccc agtgtgacgt gccccccaac    180

agcagattcg actgcgcccc tgacaaggcc atcacccagg aacagtgcga ggccagaggc    240

tgctgctaca tccctgccaa gcagggactg cagggcgctc agatgggaca gccctggtgc    300

ttcttcccac cctcctaccc cagctacaag ctggaaaacc tgagcagcag cgagatgggc    360

tacaccgcca ccctgaccag aaccaccccc acattcttcc caaaggacat cctgaccctg    420

cggctggacg tgatgatgga aaccgagaac cggctgcact tcaccatcaa ggaccccgcc    480

aatcggagat acgaggtgcc cctggaaacc ccccacgtgc actctagagc ccccagccct    540

ctgtacagcg tggaattcag cgaggaaccc ttcggcgtga tcgtgcggag acagctggat    600

ggcagagtgc tgctgaacac caccgtggcc cctctgttct tcgccgacca gttcctgcag    660

ctgagcacca gcctgcccag ccagtacatc acaggactgg ccgagcacct gagccccctg    720

atgctgagca catcctggac ccggatcacc ctgtggaaca gggatctggc ccctacccct    780

ggcgccaatc tgtacggcag ccaccctttc tacctggccc tggaagatgg cggatctgcc    840

cacggagtgt ttctgctgaa ctccaacgcc atggacgtgg tgctgcagcc tagccctgcc    900

ctgtcttgga gaagcacagg cggcatcctg gatgtgtaca tctttctggg ccccgagccc    960

aagagcgtgg tgcagcagta tctggatgtc gtgggctacc ccttcatgcc cccttactgg   1020

ggcctgggat tccacctgtg cagatggggc tactccagca ccgccatcac cagacaggtg   1080

gtggaaaaca tgaccagagc ccacttccca ctggatgtgc agtggaacga cctggactac   1140

atggacagca gacgggactt caccttcaac aaggacggct tccgggactt ccccgccatg   1200

gtgcaggaac tgcatcaggg cggcagacgg tacatgatga tcgtggatcc cgccatcagc   1260

tcctctggcc ctgccggctc ttacagaccc tacgacgagg gcctgcggag aggcgtgttc   1320

atcaccaacg agacaggcca gcccctgatc ggcaaagtgt ggcctggcag cacagccttc   1380

cccgacttca ccaatcctac cgccctggct tggtgggagg acatggtggc cgagttccac   1440

gaccaggtgc ccttcgacgg catgtggatc gacatgaacg agcccagcaa cttcatccgg   1500

ggcagcgagg atggctgccc caacaacgaa ctggaaaatc ccccttacgt gcccggcgtc   1560

gtgggcggaa cactgcaggc cgctacaatc tgtgccagca gccaccagtt tctgagcacc   1620

cactacaacc tgcacaacct gtacggcctg accgaggcca ttgccagcca ccgcgctctc   1680

gtgaaagcca gaggcacacg gcccttcgtg atcagcagaa gcacctttgc cggccacggc   1740

agatacgccg gacattggac tggcgacgtg tggtcctctt gggagcagct ggcctctagc   1800

gtgcccgaga tcctgcagtt caatctgctg ggcgtgccac tcgtgggcgc cgatgtgtgt   1860

ggcttcctgg gcaacacctc cgaggaactg tgtgtgcggt ggacacagct gggcgccttc   1920

taccctttca tgagaaacca caacagcctg ctgagcctgc cccaggaacc ctacagcttt   1980

agcgagcctg cacagcaggc catgcggaag gccctgacac tgagatacgc tctgctgccc   2040

cacctgtaca ccctgtttca ccaggcccat gtggccggcg agacagtggc cagacctctg   2100

tttctggaat tccccaagga cagcagcacc tggaccgtgg accatcagct gctgtgggga   2160

gaggctctgc tgattacccc agtgctgcag gcaggcaagg ccgaagtgac cggctacttt   2220

cccctgggca cttggtacga cctgcagacc gtgcctgtgg aagccctggg atctctgcct   2280

ccacctcctg ccgctcctag agagcctgcc attcactctg agggccagtg ggtcacactg   2340

cctgcccccc tggataccat caacgtgcac ctgagggccg gctacatcat accactgcag   2400

ggacctggcc tgaccaccac cgagtctaga cagcagccaa tggccctggc cgtggccctg   2460

accaaaggcg gagaagctag gggcgagctg ttctgggacg atggcgagag cctggaagtg   2520

ctggaaagag gcgcctatac ccaagtgatc ttcctggccc ggaacaacac catcgtgaac   2580

gagctggtgc gcgtgacctc tgaaggcgct ggactgcagc tgcagaaagt gaccgtgctg   2640

ggagtggcca cagcccctca gcaggtgctg tctaatggcg tgcccgtgtc caacttcacc   2700

tacagccccg acaccaaggt gctggacatc tgcgtgtcac tgctgatggg agagcagttt   2760

ctggtgtcct ggtgctga                                                 2778


<210>  3
<211>  2778
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco2 w/o sp

<400>  3
ggacacatcc tgctgcacga cttcctgttg gtgcctagag agctgagcgg atcatcccca     60

gtgctggagg agactcatcc tgctcaccaa cagggagctt ccagaccagg accgagagac    120

gcccaagccc atcctggtag accaagagct gtgcctaccc aatgcgacgt gccacccaac    180

tcccgattcg actgcgcgcc agataaggct attacccaag agcagtgtga agccagaggt    240

tgctgctaca tcccagcgaa gcaaggattg caaggcgccc aaatgggaca accttggtgt    300

ttcttccccc cttcgtaccc atcatataaa ctcgaaaacc tgtcctcttc ggaaatgggt    360

tatactgcca ccctcaccag aactactcct actttcttcc cgaaagacat cttgaccttg    420

aggctggacg tgatgatgga gactgaaaac cggctgcatt tcactatcaa agatcctgcc    480

aatcggcgat acgaggtccc tctggaaacc cctcacgtgc actcacgggc tccttctccg    540

ctttactccg tcgaattctc tgaggaaccc ttcggagtga tcgttagacg ccagctggat    600

ggtagagtgc tgttgaacac tactgtggcc ccacttttct tcgctgacca gtttctgcaa    660

ctgtccactt ccctgccatc ccagtacatt actggactcg ccgaacacct gtcgccactg    720

atgctctcga cctcttggac tagaatcact ttgtggaaca gagacttggc ccctactccg    780

ggagcaaatc tgtacggaag ccaccctttt tacctggcgc tcgaagatgg cggatccgct    840

cacggagtgt tcctgctgaa tagcaacgca atggacgtgg tgctgcaacc ttcccctgca    900

ctcagttgga gaagtaccgg gggtattctg gacgtgtaca tcttcctcgg accagaaccc    960

aagagcgtgg tgcagcaata tctggacgtg gtcggatacc cttttatgcc tccttactgg   1020

ggactgggat tccacctttg ccgttggggc tactcatcca ccgccattac cagacaggtg   1080

gtggagaata tgaccagagc ccacttccct ctcgacgtgc agtggaacga tctggactat   1140

atggactccc ggagagattt caccttcaac aaggacgggt tccgcgattt tcccgcgatg   1200

gttcaagagc tccaccaggg tggtcgaaga tatatgatga tcgtcgaccc agccatttcg   1260

agcagcggac ccgctggatc ttatagacct tacgacgaag gccttaggag aggagtgttc   1320

atcacaaacg agactggaca gcctttgatc ggtaaagtgt ggcctggatc aaccgccttt   1380

cctgacttta ccaatcccac tgccttggct tggtgggagg acatggtggc cgaattccac   1440

gaccaagtcc cctttgatgg aatgtggatc gatatgaacg aaccaagcaa ttttatcaga   1500

ggttccgaag acggttgccc caacaacgaa ctggaaaacc ctccttatgt gcccggagtc   1560

gtgggcggaa cattacaggc cgcgactatt tgcgccagca gccaccaatt cctgtccact   1620

cactacaacc tccacaacct ttatggatta accgaagcta ttgcaagtca cagggctctg   1680

gtgaaggcta gagggactag gccctttgtg atctcccgat ccacctttgc cggacacggg   1740

agatacgccg gtcactggac tggtgacgtg tggagctcat gggaacaact ggcctcctcc   1800

gtgccggaaa tcttacagtt caaccttctg ggtgtccctc ttgtcggagc agacgtgtgt   1860

gggtttcttg gtaacacctc cgaggaactg tgtgtgcgct ggactcaact gggtgcattc   1920

tacccattca tgagaaacca caactccttg ctgtccctgc cacaagagcc ctactcgttc   1980

agcgagcctg cacaacaggc tatgcggaag gcactgaccc tgagatacgc cctgcttcca   2040

cacttataca ctctcttcca tcaagcgcat gtggcaggag aaaccgttgc aaggcctctt   2100

ttccttgaat tccccaagga ttcctcgact tggacggtgg atcatcagct gctgtgggga   2160

gaagctctgc tgattactcc agtgttgcaa gccggaaaag ctgaggtgac cggatacttt   2220

ccgctgggaa cctggtacga cctccagact gtccctgttg aagcccttgg atcactgcct   2280

ccgcctccgg cagctccacg cgaaccagct atacattccg agggacagtg ggttacatta   2340

ccagctcctc tggacacaat caacgtccac ttaagagctg gctacattat ccctctgcaa   2400

ggaccaggac tgactacgac cgagagcaga cagcagccaa tggcactggc tgtggctctg   2460

accaagggag gggaagctag aggagaactc ttctgggatg atggggagtc ccttgaagtg   2520

ctggaaagag gcgcttacac tcaagtcatt ttccttgcac ggaacaacac cattgtgaac   2580

gaattggtgc gagtgaccag cgaaggagct ggacttcaac tgcagaaggt cactgtgctc   2640

ggagtggcta ccgctcctca gcaagtgctg tcgaatggag tccccgtgtc aaactttacc   2700

tactcccctg acactaaggt gctcgacatt tgcgtgtccc tcctgatggg agagcagttc   2760

cttgtgtcct ggtgttga                                                 2778


<210>  4
<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  hGAAwt w/o sp

<400>  4

Gly His Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser 
1               5                   10                  15      


Gly Ser Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly 
            20                  25                  30          


Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro 
        35                  40                  45              


Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp 
    50                  55                  60                  


Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly 
65                  70                  75                  80  


Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly 
                85                  90                  95      


Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu 
            100                 105                 110         


Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr 
        115                 120                 125             


Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val 
    130                 135                 140                 


Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala 
145                 150                 155                 160 


Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg 
                165                 170                 175     


Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly 
            180                 185                 190         


Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr 
        195                 200                 205             


Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser 
    210                 215                 220                 


Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu 
225                 230                 235                 240 


Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu 
                245                 250                 255     


Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu 
            260                 265                 270         


Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser 
        275                 280                 285             


Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg 
    290                 295                 300                 


Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro 
305                 310                 315                 320 


Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met 
                325                 330                 335     


Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser 
            340                 345                 350         


Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His 
        355                 360                 365             


Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg 
    370                 375                 380                 


Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met 
385                 390                 395                 400 


Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp 
                405                 410                 415     


Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp 
            420                 425                 430         


Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro 
        435                 440                 445             


Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr 
    450                 455                 460                 


Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His 
465                 470                 475                 480 


Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser 
                485                 490                 495     


Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu 
            500                 505                 510         


Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala 
        515                 520                 525             


Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu 
    530                 535                 540                 


His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu 
545                 550                 555                 560 


Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe 
                565                 570                 575     


Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser 
            580                 585                 590         


Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn 
        595                 600                 605             


Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly 
    610                 615                 620                 


Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe 
625                 630                 635                 640 


Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu 
                645                 650                 655     


Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu 
            660                 665                 670         


Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln 
        675                 680                 685             


Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe 
    690                 695                 700                 


Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly 
705                 710                 715                 720 


Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val 
                725                 730                 735     


Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro 
            740                 745                 750         


Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu 
        755                 760                 765             


Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu 
    770                 775                 780                 


Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln 
785                 790                 795                 800 


Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu 
                805                 810                 815     


Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp 
            820                 825                 830         


Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln 
        835                 840                 845             


Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg 
    850                 855                 860                 


Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu 
865                 870                 875                 880 


Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val 
                885                 890                 895     


Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val 
            900                 905                 910         


Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
        915                 920                 925 


<210>  5
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  6
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro Arg Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val His Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Ile Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  7
<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  hGAAwt w/o sp

<400>  7

Gly His Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser 
1               5                   10                  15      


Gly Ser Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly 
            20                  25                  30          


Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro 
        35                  40                  45              


Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp 
    50                  55                  60                  


Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly 
65                  70                  75                  80  


Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly 
                85                  90                  95      


Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu 
            100                 105                 110         


Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr 
        115                 120                 125             


Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val 
    130                 135                 140                 


Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala 
145                 150                 155                 160 


Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg 
                165                 170                 175     


Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly 
            180                 185                 190         


Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr 
        195                 200                 205             


Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser 
    210                 215                 220                 


Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu 
225                 230                 235                 240 


Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu 
                245                 250                 255     


Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu 
            260                 265                 270         


Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser 
        275                 280                 285             


Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg 
    290                 295                 300                 


Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro 
305                 310                 315                 320 


Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met 
                325                 330                 335     


Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser 
            340                 345                 350         


Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His 
        355                 360                 365             


Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg 
    370                 375                 380                 


Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met 
385                 390                 395                 400 


Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp 
                405                 410                 415     


Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp 
            420                 425                 430         


Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro 
        435                 440                 445             


Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr 
    450                 455                 460                 


Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His 
465                 470                 475                 480 


Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser 
                485                 490                 495     


Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu 
            500                 505                 510         


Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala 
        515                 520                 525             


Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu 
    530                 535                 540                 


His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu 
545                 550                 555                 560 


Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe 
                565                 570                 575     


Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser 
            580                 585                 590         


Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn 
        595                 600                 605             


Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly 
    610                 615                 620                 


Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe 
625                 630                 635                 640 


Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu 
                645                 650                 655     


Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu 
            660                 665                 670         


Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln 
        675                 680                 685             


Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe 
    690                 695                 700                 


Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly 
705                 710                 715                 720 


Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val 
                725                 730                 735     


Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro 
            740                 745                 750         


Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu 
        755                 760                 765             


Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu 
    770                 775                 780                 


Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln 
785                 790                 795                 800 


Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu 
                805                 810                 815     


Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp 
            820                 825                 830         


Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln 
        835                 840                 845             


Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg 
    850                 855                 860                 


Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu 
865                 870                 875                 880 


Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val 
                885                 890                 895     


Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val 
            900                 905                 910         


Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
        915                 920                 925 


<210>  8
<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  variant hGAAwt w/o sp

<400>  8

Gly His Ile Leu Leu His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser 
1               5                   10                  15      


Gly Ser Ser Pro Val Leu Glu Glu Thr His Pro Ala His Gln Gln Gly 
            20                  25                  30          


Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro 
        35                  40                  45              


Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp 
    50                  55                  60                  


Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly 
65                  70                  75                  80  


Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly 
                85                  90                  95      


Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu 
            100                 105                 110         


Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr 
        115                 120                 125             


Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val 
    130                 135                 140                 


Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala 
145                 150                 155                 160 


Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro Arg Val His Ser Arg 
                165                 170                 175     


Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly 
            180                 185                 190         


Val Ile Val His Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr 
        195                 200                 205             


Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser 
    210                 215                 220                 


Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu 
225                 230                 235                 240 


Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu 
                245                 250                 255     


Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu 
            260                 265                 270         


Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser 
        275                 280                 285             


Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg 
    290                 295                 300                 


Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro 
305                 310                 315                 320 


Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met 
                325                 330                 335     


Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser 
            340                 345                 350         


Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His 
        355                 360                 365             


Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg 
    370                 375                 380                 


Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met 
385                 390                 395                 400 


Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp 
                405                 410                 415     


Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp 
            420                 425                 430         


Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro 
        435                 440                 445             


Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr 
    450                 455                 460                 


Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His 
465                 470                 475                 480 


Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser 
                485                 490                 495     


Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu 
            500                 505                 510         


Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala 
        515                 520                 525             


Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu 
    530                 535                 540                 


His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu 
545                 550                 555                 560 


Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe 
                565                 570                 575     


Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser 
            580                 585                 590         


Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn 
        595                 600                 605             


Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly 
    610                 615                 620                 


Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe 
625                 630                 635                 640 


Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu 
                645                 650                 655     


Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu 
            660                 665                 670         


Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln 
        675                 680                 685             


Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe 
    690                 695                 700                 


Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly 
705                 710                 715                 720 


Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val 
                725                 730                 735     


Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro 
            740                 745                 750         


Ile Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu 
        755                 760                 765             


Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu 
    770                 775                 780                 


Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln 
785                 790                 795                 800 


Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu 
                805                 810                 815     


Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp 
            820                 825                 830         


Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln 
        835                 840                 845             


Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg 
    850                 855                 860                 


Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu 
865                 870                 875                 880 


Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val 
                885                 890                 895     


Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val 
            900                 905                 910         


Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
        915                 920                 925 


<210>  9
<211>  883
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of delta42 GAA

<400>  9

Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro 
1               5                   10                  15      


Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu 
            20                  25                  30          


Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu 
        35                  40                  45              


Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr 
    50                  55                  60                  


Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr 
65                  70                  75                  80  


Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu 
                85                  90                  95      


Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe 
            100                 105                 110         


Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr 
        115                 120                 125             


Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe 
    130                 135                 140                 


Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg 
145                 150                 155                 160 


Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe 
                165                 170                 175     


Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala 
            180                 185                 190         


Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr 
        195                 200                 205             


Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly 
    210                 215                 220                 


Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly 
225                 230                 235                 240 


Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser 
                245                 250                 255     


Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile 
            260                 265                 270         


Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val 
        275                 280                 285             


Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu 
    290                 295                 300                 


Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu 
305                 310                 315                 320 


Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu 
                325                 330                 335     


Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe 
            340                 345                 350         


Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg 
        355                 360                 365             


Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly 
    370                 375                 380                 


Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr 
385                 390                 395                 400 


Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr 
                405                 410                 415     


Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp 
            420                 425                 430         


Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile 
        435                 440                 445             


Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys 
    450                 455                 460                 


Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly 
465                 470                 475                 480 


Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu 
                485                 490                 495     


Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile 
            500                 505                 510         


Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val 
        515                 520                 525             


Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp 
    530                 535                 540                 


Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro 
545                 550                 555                 560 


Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp 
                565                 570                 575     


Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp 
            580                 585                 590         


Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu 
        595                 600                 605             


Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln 
    610                 615                 620                 


Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu 
625                 630                 635                 640 


Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg 
                645                 650                 655     


Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp 
            660                 665                 670         


His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln 
        675                 680                 685             


Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr 
    690                 695                 700                 


Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro 
705                 710                 715                 720 


Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val 
                725                 730                 735     


Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly 
            740                 745                 750         


Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg 
        755                 760                 765             


Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala 
    770                 775                 780                 


Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu 
785                 790                 795                 800 


Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile 
                805                 810                 815     


Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu 
            820                 825                 830         


Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu 
        835                 840                 845             


Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys 
    850                 855                 860                 


Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val 
865                 870                 875                 880 


Ser Trp Cys 
            


<210>  10
<211>  2652
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco1-delta-42

<400>  10
gcccaccccg gcagacctag agctgtgcct acccagtgtg acgtgccccc caacagcaga     60

ttcgactgcg cccctgacaa ggccatcacc caggaacagt gcgaggccag aggctgctgc    120

tacatccctg ccaagcaggg actgcagggc gctcagatgg gacagccctg gtgcttcttc    180

ccaccctcct accccagcta caagctggaa aacctgagca gcagcgagat gggctacacc    240

gccaccctga ccagaaccac ccccacattc ttcccaaagg acatcctgac cctgcggctg    300

gacgtgatga tggaaaccga gaaccggctg cacttcacca tcaaggaccc cgccaatcgg    360

agatacgagg tgcccctgga aaccccccac gtgcactcta gagcccccag ccctctgtac    420

agcgtggaat tcagcgagga acccttcggc gtgatcgtgc ggagacagct ggatggcaga    480

gtgctgctga acaccaccgt ggcccctctg ttcttcgccg accagttcct gcagctgagc    540

accagcctgc ccagccagta catcacagga ctggccgagc acctgagccc cctgatgctg    600

agcacatcct ggacccggat caccctgtgg aacagggatc tggcccctac ccctggcgcc    660

aatctgtacg gcagccaccc tttctacctg gccctggaag atggcggatc tgcccacgga    720

gtgtttctgc tgaactccaa cgccatggac gtggtgctgc agcctagccc tgccctgtct    780

tggagaagca caggcggcat cctggatgtg tacatctttc tgggccccga gcccaagagc    840

gtggtgcagc agtatctgga tgtcgtgggc taccccttca tgccccctta ctggggcctg    900

ggattccacc tgtgcagatg gggctactcc agcaccgcca tcaccagaca ggtggtggaa    960

aacatgacca gagcccactt cccactggat gtgcagtgga acgacctgga ctacatggac   1020

agcagacggg acttcacctt caacaaggac ggcttccggg acttccccgc catggtgcag   1080

gaactgcatc agggcggcag acggtacatg atgatcgtgg atcccgccat cagctcctct   1140

ggccctgccg gctcttacag accctacgac gagggcctgc ggagaggcgt gttcatcacc   1200

aacgagacag gccagcccct gatcggcaaa gtgtggcctg gcagcacagc cttccccgac   1260

ttcaccaatc ctaccgccct ggcttggtgg gaggacatgg tggccgagtt ccacgaccag   1320

gtgcccttcg acggcatgtg gatcgacatg aacgagccca gcaacttcat ccggggcagc   1380

gaggatggct gccccaacaa cgaactggaa aatccccctt acgtgcccgg cgtcgtgggc   1440

ggaacactgc aggccgctac aatctgtgcc agcagccacc agtttctgag cacccactac   1500

aacctgcaca acctgtacgg cctgaccgag gccattgcca gccaccgcgc tctcgtgaaa   1560

gccagaggca cacggccctt cgtgatcagc agaagcacct ttgccggcca cggcagatac   1620

gccggacatt ggactggcga cgtgtggtcc tcttgggagc agctggcctc tagcgtgccc   1680

gagatcctgc agttcaatct gctgggcgtg ccactcgtgg gcgccgatgt gtgtggcttc   1740

ctgggcaaca cctccgagga actgtgtgtg cggtggacac agctgggcgc cttctaccct   1800

ttcatgagaa accacaacag cctgctgagc ctgccccagg aaccctacag ctttagcgag   1860

cctgcacagc aggccatgcg gaaggccctg acactgagat acgctctgct gccccacctg   1920

tacaccctgt ttcaccaggc ccatgtggcc ggcgagacag tggccagacc tctgtttctg   1980

gaattcccca aggacagcag cacctggacc gtggaccatc agctgctgtg gggagaggct   2040

ctgctgatta ccccagtgct gcaggcaggc aaggccgaag tgaccggcta ctttcccctg   2100

ggcacttggt acgacctgca gaccgtgcct gtggaagccc tgggatctct gcctccacct   2160

cctgccgctc ctagagagcc tgccattcac tctgagggcc agtgggtcac actgcctgcc   2220

cccctggata ccatcaacgt gcacctgagg gccggctaca tcataccact gcagggacct   2280

ggcctgacca ccaccgagtc tagacagcag ccaatggccc tggccgtggc cctgaccaaa   2340

ggcggagaag ctaggggcga gctgttctgg gacgatggcg agagcctgga agtgctggaa   2400

agaggcgcct atacccaagt gatcttcctg gcccggaaca acaccatcgt gaacgagctg   2460

gtgcgcgtga cctctgaagg cgctggactg cagctgcaga aagtgaccgt gctgggagtg   2520

gccacagccc ctcagcaggt gctgtctaat ggcgtgcccg tgtccaactt cacctacagc   2580

cccgacacca aggtgctgga catctgcgtg tcactgctga tgggagagca gtttctggtg   2640

tcctggtgct ga                                                       2652


<210>  11
<211>  2652
<212>  DNA
<213>  artificial

<220>
<223>  hGAAco2-delta-42

<400>  11
gcccatcctg gtagaccaag agctgtgcct acccaatgcg acgtgccacc caactcccga     60

ttcgactgcg cgccagataa ggctattacc caagagcagt gtgaagccag aggttgctgc    120

tacatcccag cgaagcaagg attgcaaggc gcccaaatgg gacaaccttg gtgtttcttc    180

cccccttcgt acccatcata taaactcgaa aacctgtcct cttcggaaat gggttatact    240

gccaccctca ccagaactac tcctactttc ttcccgaaag acatcttgac cttgaggctg    300

gacgtgatga tggagactga aaaccggctg catttcacta tcaaagatcc tgccaatcgg    360

cgatacgagg tccctctgga aacccctcac gtgcactcac gggctccttc tccgctttac    420

tccgtcgaat tctctgagga acccttcgga gtgatcgtta gacgccagct ggatggtaga    480

gtgctgttga acactactgt ggccccactt ttcttcgctg accagtttct gcaactgtcc    540

acttccctgc catcccagta cattactgga ctcgccgaac acctgtcgcc actgatgctc    600

tcgacctctt ggactagaat cactttgtgg aacagagact tggcccctac tccgggagca    660

aatctgtacg gaagccaccc tttttacctg gcgctcgaag atggcggatc cgctcacgga    720

gtgttcctgc tgaatagcaa cgcaatggac gtggtgctgc aaccttcccc tgcactcagt    780

tggagaagta ccgggggtat tctggacgtg tacatcttcc tcggaccaga acccaagagc    840

gtggtgcagc aatatctgga cgtggtcgga taccctttta tgcctcctta ctggggactg    900

ggattccacc tttgccgttg gggctactca tccaccgcca ttaccagaca ggtggtggag    960

aatatgacca gagcccactt ccctctcgac gtgcagtgga acgatctgga ctatatggac   1020

tcccggagag atttcacctt caacaaggac gggttccgcg attttcccgc gatggttcaa   1080

gagctccacc agggtggtcg aagatatatg atgatcgtcg acccagccat ttcgagcagc   1140

ggacccgctg gatcttatag accttacgac gaaggcctta ggagaggagt gttcatcaca   1200

aacgagactg gacagccttt gatcggtaaa gtgtggcctg gatcaaccgc ctttcctgac   1260

tttaccaatc ccactgcctt ggcttggtgg gaggacatgg tggccgaatt ccacgaccaa   1320

gtcccctttg atggaatgtg gatcgatatg aacgaaccaa gcaattttat cagaggttcc   1380

gaagacggtt gccccaacaa cgaactggaa aaccctcctt atgtgcccgg agtcgtgggc   1440

ggaacattac aggccgcgac tatttgcgcc agcagccacc aattcctgtc cactcactac   1500

aacctccaca acctttatgg attaaccgaa gctattgcaa gtcacagggc tctggtgaag   1560

gctagaggga ctaggccctt tgtgatctcc cgatccacct ttgccggaca cgggagatac   1620

gccggtcact ggactggtga cgtgtggagc tcatgggaac aactggcctc ctccgtgccg   1680

gaaatcttac agttcaacct tctgggtgtc cctcttgtcg gagcagacgt gtgtgggttt   1740

cttggtaaca cctccgagga actgtgtgtg cgctggactc aactgggtgc attctaccca   1800

ttcatgagaa accacaactc cttgctgtcc ctgccacaag agccctactc gttcagcgag   1860

cctgcacaac aggctatgcg gaaggcactg accctgagat acgccctgct tccacactta   1920

tacactctct tccatcaagc gcatgtggca ggagaaaccg ttgcaaggcc tcttttcctt   1980

gaattcccca aggattcctc gacttggacg gtggatcatc agctgctgtg gggagaagct   2040

ctgctgatta ctccagtgtt gcaagccgga aaagctgagg tgaccggata ctttccgctg   2100

ggaacctggt acgacctcca gactgtccct gttgaagccc ttggatcact gcctccgcct   2160

ccggcagctc cacgcgaacc agctatacat tccgagggac agtgggttac attaccagct   2220

cctctggaca caatcaacgt ccacttaaga gctggctaca ttatccctct gcaaggacca   2280

ggactgacta cgaccgagag cagacagcag ccaatggcac tggctgtggc tctgaccaag   2340

ggaggggaag ctagaggaga actcttctgg gatgatgggg agtcccttga agtgctggaa   2400

agaggcgctt acactcaagt cattttcctt gcacggaaca acaccattgt gaacgaattg   2460

gtgcgagtga ccagcgaagg agctggactt caactgcaga aggtcactgt gctcggagtg   2520

gctaccgctc ctcagcaagt gctgtcgaat ggagtccccg tgtcaaactt tacctactcc   2580

cctgacacta aggtgctcga catttgcgtg tccctcctga tgggagagca gttccttgtg   2640

tcctggtgtt ga                                                       2652


<210>  12
<211>  28
<212>  PRT
<213>  artificial

<220>
<223>  amino acid sequence of the CTP

<400>  12

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


<210>  13
<211>  84
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid sequence encoding the CTP (HD4)

<400>  13
agcagcagct ctaaagcccc tccacctagc ctgccttctc caagcagact gcctggacct     60

agcgacaccc ctattctgcc tcaa                                            84


<210>  14
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  SPADIN (HD6)

<400>  14
gctccacttc ctcgttggag tggccctatc ggagtgtctt ggggactgag a              51


<210>  15
<211>  39
<212>  DNA
<213>  artificial

<220>
<223>  Neurotensin (HD7)

<400>  15
cagctgtacg agaacaagcc cagacggccc tacatcctg                            39


<210>  16
<211>  15
<212>  DNA
<213>  artificial

<220>
<223>  Neurotensin fragment (HD8)

<400>  16
cggccctaca tcctg                                                      15


<210>  17
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  linker

<400>  17
ggcgcgccg                                                              9


<210>  18
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  sp1

<400>  18

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu 
            20                  25          


<210>  19
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  sp2

<400>  19

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210>  20
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  sp6

<400>  20

Met Pro Pro Pro Arg Thr Gly Arg Gly Leu Leu Trp Leu Gly Leu Val 
1               5                   10                  15      


Leu Ser Ser Val Cys Val Ala Leu Gly 
            20                  25  


<210>  21
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  sp7

<400>  21

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  22
<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  sp8

<400>  22

Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser 
            20          


<210>  23
<211>  397
<212>  DNA
<213>  artificial

<220>
<223>  hAAT promoter

<400>  23
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta     60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac    120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca    180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact    240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct    300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct    360

cagcttcagg caccaccact gacctgggac agtgaat                             397


<210>  24
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  ApoE control region

<400>  24
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg g                                              321


<210>  25
<211>  441
<212>  DNA
<213>  artificial

<220>
<223>  HBB2 intron

<400>  25
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt     60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca    120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata    180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt    240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt    300

ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa    360

tcatgttcat acctcttatc ttcctcccac agctcctggg caacgtgctg gtctgtgtgc    420

tggcccatca ctttggcaaa g                                              441


<210>  26
<211>  441
<212>  DNA
<213>  artificial

<220>
<223>  modified HBB2 intron

<400>  26
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt     60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca    120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata    180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt    240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt    300

ttattttctg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa    360

tcttgttcat acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc    420

tggcccatca ctttggcaaa g                                              441


<210>  27
<211>  1438
<212>  DNA
<213>  artificial

<220>
<223>  FIX intron

<400>  27
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct     60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta    120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc    180

atttttaaaa ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt    240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa    300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta    360

tttttgtttg gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc    420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt    480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa    540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta    600

ggaaaaaatc attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa    660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga    720

agttagctaa tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt    780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac    840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt    900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc    960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt   1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc   1080

agggtgatgg atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg   1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt   1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt   1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct   1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta   1380

aaattttcat gatgttttct tttttgctaa aactaaagaa ttattctttt acatttca     1438


<210>  28
<211>  1438
<212>  DNA
<213>  artificial

<220>
<223>  modified FIX intron

<400>  28
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct     60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta    120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc    180

atttttaaaa ctaaatagat cgacattgct tttgttgcat ttatgtttaa taaacactgt    240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa    300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta    360

tttttgtttg gacttaccac tttgaaatca aattgggaaa caaaagcaca aacaatggcc    420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt    480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa    540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta    600

ggaaaaaatc attttgtctc tttgtcaaac atcttggagt tgatatttgg ggaaacacaa    660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga    720

agttagctat tgcaacatat atcactttgt tttttcacaa ctacagtgac tttttgtatt    780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc ttgttctcac    840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt    900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc    960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt   1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc   1080

agggtgttgg atcactttgc aaagatcctc attgagctat tttcaagtgt tgacaaagtg   1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt   1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt   1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct   1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta   1380

aaattttctt gttgttttct tttttgctaa aactaaagaa ttattctttt acatttca     1438


<210>  29
<211>  881
<212>  DNA
<213>  artificial

<220>
<223>  chicken beta-globin intron

<400>  29
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc     60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc    120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga    180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg    240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg    300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg    360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt    420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca    480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg    540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc    600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg    660

cggctgtcga ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc    720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac    780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga    840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                        881


<210>  30
<211>  881
<212>  DNA
<213>  artificial

<220>
<223>  modified chicken beta-globin intron

<400>  30
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc     60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc    120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga    180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg    240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg    300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg    360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt    420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca    480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg    540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc    600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg    660

cggctgtcga ggcgcggcga gccgcagcca ttgccttttt tggtaatcgt gcgagagggc    720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac    780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaat tgggcgggga    840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                        881


<210>  31
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  Spadin (HD6)

<400>  31

Ala Pro Leu Pro Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu 
1               5                   10                  15      


Arg 
    


<210>  32
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  Neurotensin 1-13 (HD7)

<400>  32

Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10              


<210>  33
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  Neurotensin 9-13 (HD8)

<400>  33

Arg Pro Tyr Ile Leu 
1               5   


<210>  34
<211>  165
<212>  PRT
<213>  artificial

<220>
<223>  Beta subunit of the human chorionic gonadotropin (hCG)

<400>  34

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  35
<211>  921
<212>  PRT
<213>  artificial

<220>
<223>  sp7-HDspadin-D42-hGAAco1

<400>  35

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Ala Pro Leu Pro Arg Trp Ser Gly Pro Ile Gly Val Ser Trp 
            20                  25                  30          


Gly Leu Arg Gly Ala Pro Ala His Pro Gly Arg Pro Arg Ala Val Pro 
        35                  40                  45              


Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp 
    50                  55                  60                  


Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile 
65                  70                  75                  80  


Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys 
                85                  90                  95      


Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser 
            100                 105                 110         


Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe 
        115                 120                 125             


Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr 
    130                 135                 140                 


Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr 
145                 150                 155                 160 


Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro 
                165                 170                 175     


Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg 
            180                 185                 190         


Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu 
        195                 200                 205             


Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln 
    210                 215                 220                 


Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr 
225                 230                 235                 240 


Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro 
                245                 250                 255     


Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp 
            260                 265                 270         


Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp 
        275                 280                 285             


Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly 
    290                 295                 300                 


Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val 
305                 310                 315                 320 


Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp 
                325                 330                 335     


Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile 
            340                 345                 350         


Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp 
        355                 360                 365             


Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr 
    370                 375                 380                 


Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu 
385                 390                 395                 400 


His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser 
                405                 410                 415     


Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg 
            420                 425                 430         


Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys 
        435                 440                 445             


Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala 
    450                 455                 460                 


Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro 
465                 470                 475                 480 


Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg 
                485                 490                 495     


Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr 
            500                 505                 510         


Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala 
        515                 520                 525             


Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr 
    530                 535                 540                 


Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg 
545                 550                 555                 560 


Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly 
                565                 570                 575     


Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln 
            580                 585                 590         


Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val 
        595                 600                 605             


Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu 
    610                 615                 620                 


Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met 
625                 630                 635                 640 


Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe 
                645                 650                 655     


Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr 
            660                 665                 670         


Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala 
        675                 680                 685             


Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser 
    690                 695                 700                 


Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu 
705                 710                 715                 720 


Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe 
                725                 730                 735     


Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu 
            740                 745                 750         


Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His 
        755                 760                 765             


Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn 
    770                 775                 780                 


Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu 
785                 790                 795                 800 


Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu 
                805                 810                 815     


Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu 
            820                 825                 830         


Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu 
        835                 840                 845             


Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu 
    850                 855                 860                 


Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr 
865                 870                 875                 880 


Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr 
                885                 890                 895     


Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met 
            900                 905                 910         


Gly Glu Gln Phe Leu Val Ser Trp Cys 
        915                 920     


<210>  36
<211>  917
<212>  PRT
<213>  artificial

<220>
<223>  sp7-HD NT1-13-D42-hGAAco1

<400>  36

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu Gly 
            20                  25                  30          


Ala Pro Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp 
        35                  40                  45              


Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr 
    50                  55                  60                  


Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln 
65                  70                  75                  80  


Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro 
                85                  90                  95      


Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly 
            100                 105                 110         


Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp 
        115                 120                 125             


Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu 
    130                 135                 140                 


His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu 
145                 150                 155                 160 


Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val 
                165                 170                 175     


Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp 
            180                 185                 190         


Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp 
        195                 200                 205             


Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly 
    210                 215                 220                 


Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg 
225                 230                 235                 240 


Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu 
                245                 250                 255     


Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala 
            260                 265                 270         


His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln 
        275                 280                 285             


Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val 
    290                 295                 300                 


Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu 
305                 310                 315                 320 


Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe 
                325                 330                 335     


His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val 
            340                 345                 350         


Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn 
        355                 360                 365             


Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp 
    370                 375                 380                 


Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly 
385                 390                 395                 400 


Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro 
                405                 410                 415     


Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe 
            420                 425                 430         


Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly 
        435                 440                 445             


Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp 
    450                 455                 460                 


Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met 
465                 470                 475                 480 


Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp 
                485                 490                 495     


Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val 
            500                 505                 510         


Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln 
        515                 520                 525             


Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu 
    530                 535                 540                 


Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro 
545                 550                 555                 560 


Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly 
                565                 570                 575     


His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser 
            580                 585                 590         


Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly 
        595                 600                 605             


Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val 
    610                 615                 620                 


Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn 
625                 630                 635                 640 


Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala 
                645                 650                 655     


Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro 
            660                 665                 670         


His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val 
        675                 680                 685             


Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr 
    690                 695                 700                 


Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val 
705                 710                 715                 720 


Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr 
                725                 730                 735     


Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro 
            740                 745                 750         


Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln 
        755                 760                 765             


Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg 
    770                 775                 780                 


Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu 
785                 790                 795                 800 


Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly 
                805                 810                 815     


Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val 
            820                 825                 830         


Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn 
        835                 840                 845             


Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu 
    850                 855                 860                 


Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln 
865                 870                 875                 880 


Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp 
                885                 890                 895     


Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe 
            900                 905                 910         


Leu Val Ser Trp Cys 
        915         


<210>  37
<211>  909
<212>  PRT
<213>  artificial

<220>
<223>  sp7-HD NT9-13 -D42hGAAco1

<400>  37

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly Arg Pro Tyr Ile Leu Gly Ala Pro Ala His Pro Gly Arg Pro 
            20                  25                  30          


Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp 
        35                  40                  45              


Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly 
    50                  55                  60                  


Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly 
65                  70                  75                  80  


Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu 
                85                  90                  95      


Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr 
            100                 105                 110         


Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val 
        115                 120                 125             


Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala 
    130                 135                 140                 


Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg 
145                 150                 155                 160 


Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly 
                165                 170                 175     


Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr 
            180                 185                 190         


Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser 
        195                 200                 205             


Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu 
    210                 215                 220                 


Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu 
225                 230                 235                 240 


Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu 
                245                 250                 255     


Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser 
            260                 265                 270         


Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg 
        275                 280                 285             


Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro 
    290                 295                 300                 


Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met 
305                 310                 315                 320 


Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser 
                325                 330                 335     


Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His 
            340                 345                 350         


Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg 
        355                 360                 365             


Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met 
    370                 375                 380                 


Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp 
385                 390                 395                 400 


Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp 
                405                 410                 415     


Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro 
            420                 425                 430         


Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr 
        435                 440                 445             


Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His 
    450                 455                 460                 


Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser 
465                 470                 475                 480 


Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu 
                485                 490                 495     


Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala 
            500                 505                 510         


Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu 
        515                 520                 525             


His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu 
    530                 535                 540                 


Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe 
545                 550                 555                 560 


Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser 
                565                 570                 575     


Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn 
            580                 585                 590         


Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly 
        595                 600                 605             


Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe 
    610                 615                 620                 


Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu 
625                 630                 635                 640 


Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu 
                645                 650                 655     


Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln 
            660                 665                 670         


Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe 
        675                 680                 685             


Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly 
    690                 695                 700                 


Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val 
705                 710                 715                 720 


Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro 
                725                 730                 735     


Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu 
            740                 745                 750         


Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu 
        755                 760                 765             


Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln 
    770                 775                 780                 


Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu 
785                 790                 795                 800 


Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp 
                805                 810                 815     


Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln 
            820                 825                 830         


Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg 
        835                 840                 845             


Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu 
    850                 855                 860                 


Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val 
865                 870                 875                 880 


Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val 
                885                 890                 895     


Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
            900                 905                 


<210>  38
<211>  2766
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid sequence encoding sp7-HD-spadin-D42-hGAAco1

<400>  38
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggcgctcca     60

cttcctcgtt ggagtggccc tatcggagtg tcttggggac tgagaggcgc gccggcccac    120

cccggcagac ctagagctgt gcctacccag tgtgacgtgc cccccaacag cagattcgac    180

tgcgcccctg acaaggccat cacccaggaa cagtgcgagg ccagaggctg ctgctacatc    240

cctgccaagc agggactgca gggcgctcag atgggacagc cctggtgctt cttcccaccc    300

tcctacccca gctacaagct ggaaaacctg agcagcagcg agatgggcta caccgccacc    360

ctgaccagaa ccacccccac attcttccca aaggacatcc tgaccctgcg gctggacgtg    420

atgatggaaa ccgagaaccg gctgcacttc accatcaagg accccgccaa tcggagatac    480

gaggtgcccc tggaaacccc ccacgtgcac tctagagccc ccagccctct gtacagcgtg    540

gaattcagcg aggaaccctt cggcgtgatc gtgcggagac agctggatgg cagagtgctg    600

ctgaacacca ccgtggcccc tctgttcttc gccgaccagt tcctgcagct gagcaccagc    660

ctgcccagcc agtacatcac aggactggcc gagcacctga gccccctgat gctgagcaca    720

tcctggaccc ggatcaccct gtggaacagg gatctggccc ctacccctgg cgccaatctg    780

tacggcagcc accctttcta cctggccctg gaagatggcg gatctgccca cggagtgttt    840

ctgctgaact ccaacgccat ggacgtggtg ctgcagccta gccctgccct gtcttggaga    900

agcacaggcg gcatcctgga tgtgtacatc tttctgggcc ccgagcccaa gagcgtggtg    960

cagcagtatc tggatgtcgt gggctacccc ttcatgcccc cttactgggg cctgggattc   1020

cacctgtgca gatggggcta ctccagcacc gccatcacca gacaggtggt ggaaaacatg   1080

accagagccc acttcccact ggatgtgcag tggaacgacc tggactacat ggacagcaga   1140

cgggacttca ccttcaacaa ggacggcttc cgggacttcc ccgccatggt gcaggaactg   1200

catcagggcg gcagacggta catgatgatc gtggatcccg ccatcagctc ctctggccct   1260

gccggctctt acagacccta cgacgagggc ctgcggagag gcgtgttcat caccaacgag   1320

acaggccagc ccctgatcgg caaagtgtgg cctggcagca cagccttccc cgacttcacc   1380

aatcctaccg ccctggcttg gtgggaggac atggtggccg agttccacga ccaggtgccc   1440

ttcgacggca tgtggatcga catgaacgag cccagcaact tcatccgggg cagcgaggat   1500

ggctgcccca acaacgaact ggaaaatccc ccttacgtgc ccggcgtcgt gggcggaaca   1560

ctgcaggccg ctacaatctg tgccagcagc caccagtttc tgagcaccca ctacaacctg   1620

cacaacctgt acggcctgac cgaggccatt gccagccacc gcgctctcgt gaaagccaga   1680

ggcacacggc ccttcgtgat cagcagaagc acctttgccg gccacggcag atacgccgga   1740

cattggactg gcgacgtgtg gtcctcttgg gagcagctgg cctctagcgt gcccgagatc   1800

ctgcagttca atctgctggg cgtgccactc gtgggcgccg atgtgtgtgg cttcctgggc   1860

aacacctccg aggaactgtg tgtgcggtgg acacagctgg gcgccttcta ccctttcatg   1920

agaaaccaca acagcctgct gagcctgccc caggaaccct acagctttag cgagcctgca   1980

cagcaggcca tgcggaaggc cctgacactg agatacgctc tgctgcccca cctgtacacc   2040

ctgtttcacc aggcccatgt ggccggcgag acagtggcca gacctctgtt tctggaattc   2100

cccaaggaca gcagcacctg gaccgtggac catcagctgc tgtggggaga ggctctgctg   2160

attaccccag tgctgcaggc aggcaaggcc gaagtgaccg gctactttcc cctgggcact   2220

tggtacgacc tgcagaccgt gcctgtggaa gccctgggat ctctgcctcc acctcctgcc   2280

gctcctagag agcctgccat tcactctgag ggccagtggg tcacactgcc tgcccccctg   2340

gataccatca acgtgcacct gagggccggc tacatcatac cactgcaggg acctggcctg   2400

accaccaccg agtctagaca gcagccaatg gccctggccg tggccctgac caaaggcgga   2460

gaagctaggg gcgagctgtt ctgggacgat ggcgagagcc tggaagtgct ggaaagaggc   2520

gcctataccc aagtgatctt cctggcccgg aacaacacca tcgtgaacga gctggtgcgc   2580

gtgacctctg aaggcgctgg actgcagctg cagaaagtga ccgtgctggg agtggccaca   2640

gcccctcagc aggtgctgtc taatggcgtg cccgtgtcca acttcaccta cagccccgac   2700

accaaggtgc tggacatctg cgtgtcactg ctgatgggag agcagtttct ggtgtcctgg   2760

tgctga                                                              2766


<210>  39
<211>  2754
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid sequence encoding sp7-HD NT1-13-D42-hGAAco1

<400>  39
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccagctg     60

tacgagaaca agcccagacg gccctacatc ctgggcgcgc cggcccaccc cggcagacct    120

agagctgtgc ctacccagtg tgacgtgccc cccaacagca gattcgactg cgcccctgac    180

aaggccatca cccaggaaca gtgcgaggcc agaggctgct gctacatccc tgccaagcag    240

ggactgcagg gcgctcagat gggacagccc tggtgcttct tcccaccctc ctaccccagc    300

tacaagctgg aaaacctgag cagcagcgag atgggctaca ccgccaccct gaccagaacc    360

acccccacat tcttcccaaa ggacatcctg accctgcggc tggacgtgat gatggaaacc    420

gagaaccggc tgcacttcac catcaaggac cccgccaatc ggagatacga ggtgcccctg    480

gaaacccccc acgtgcactc tagagccccc agccctctgt acagcgtgga attcagcgag    540

gaacccttcg gcgtgatcgt gcggagacag ctggatggca gagtgctgct gaacaccacc    600

gtggcccctc tgttcttcgc cgaccagttc ctgcagctga gcaccagcct gcccagccag    660

tacatcacag gactggccga gcacctgagc cccctgatgc tgagcacatc ctggacccgg    720

atcaccctgt ggaacaggga tctggcccct acccctggcg ccaatctgta cggcagccac    780

cctttctacc tggccctgga agatggcgga tctgcccacg gagtgtttct gctgaactcc    840

aacgccatgg acgtggtgct gcagcctagc cctgccctgt cttggagaag cacaggcggc    900

atcctggatg tgtacatctt tctgggcccc gagcccaaga gcgtggtgca gcagtatctg    960

gatgtcgtgg gctacccctt catgccccct tactggggcc tgggattcca cctgtgcaga   1020

tggggctact ccagcaccgc catcaccaga caggtggtgg aaaacatgac cagagcccac   1080

ttcccactgg atgtgcagtg gaacgacctg gactacatgg acagcagacg ggacttcacc   1140

ttcaacaagg acggcttccg ggacttcccc gccatggtgc aggaactgca tcagggcggc   1200

agacggtaca tgatgatcgt ggatcccgcc atcagctcct ctggccctgc cggctcttac   1260

agaccctacg acgagggcct gcggagaggc gtgttcatca ccaacgagac aggccagccc   1320

ctgatcggca aagtgtggcc tggcagcaca gccttccccg acttcaccaa tcctaccgcc   1380

ctggcttggt gggaggacat ggtggccgag ttccacgacc aggtgccctt cgacggcatg   1440

tggatcgaca tgaacgagcc cagcaacttc atccggggca gcgaggatgg ctgccccaac   1500

aacgaactgg aaaatccccc ttacgtgccc ggcgtcgtgg gcggaacact gcaggccgct   1560

acaatctgtg ccagcagcca ccagtttctg agcacccact acaacctgca caacctgtac   1620

ggcctgaccg aggccattgc cagccaccgc gctctcgtga aagccagagg cacacggccc   1680

ttcgtgatca gcagaagcac ctttgccggc cacggcagat acgccggaca ttggactggc   1740

gacgtgtggt cctcttggga gcagctggcc tctagcgtgc ccgagatcct gcagttcaat   1800

ctgctgggcg tgccactcgt gggcgccgat gtgtgtggct tcctgggcaa cacctccgag   1860

gaactgtgtg tgcggtggac acagctgggc gccttctacc ctttcatgag aaaccacaac   1920

agcctgctga gcctgcccca ggaaccctac agctttagcg agcctgcaca gcaggccatg   1980

cggaaggccc tgacactgag atacgctctg ctgccccacc tgtacaccct gtttcaccag   2040

gcccatgtgg ccggcgagac agtggccaga cctctgtttc tggaattccc caaggacagc   2100

agcacctgga ccgtggacca tcagctgctg tggggagagg ctctgctgat taccccagtg   2160

ctgcaggcag gcaaggccga agtgaccggc tactttcccc tgggcacttg gtacgacctg   2220

cagaccgtgc ctgtggaagc cctgggatct ctgcctccac ctcctgccgc tcctagagag   2280

cctgccattc actctgaggg ccagtgggtc acactgcctg cccccctgga taccatcaac   2340

gtgcacctga gggccggcta catcatacca ctgcagggac ctggcctgac caccaccgag   2400

tctagacagc agccaatggc cctggccgtg gccctgacca aaggcggaga agctaggggc   2460

gagctgttct gggacgatgg cgagagcctg gaagtgctgg aaagaggcgc ctatacccaa   2520

gtgatcttcc tggcccggaa caacaccatc gtgaacgagc tggtgcgcgt gacctctgaa   2580

ggcgctggac tgcagctgca gaaagtgacc gtgctgggag tggccacagc ccctcagcag   2640

gtgctgtcta atggcgtgcc cgtgtccaac ttcacctaca gccccgacac caaggtgctg   2700

gacatctgcg tgtcactgct gatgggagag cagtttctgg tgtcctggtg ctga         2754


<210>  40
<211>  2730
<212>  DNA
<213>  artificial

<220>
<223>  nucleic acid sequence encoding sp7-HD NT 9-13 -D42hGAAco1

<400>  40
atggcctttc tgtggctgct gagctgttgg gccctgctgg gcaccacctt cggccggccc     60

tacatcctgg gcgcgccggc ccaccccggc agacctagag ctgtgcctac ccagtgtgac    120

gtgcccccca acagcagatt cgactgcgcc cctgacaagg ccatcaccca ggaacagtgc    180

gaggccagag gctgctgcta catccctgcc aagcagggac tgcagggcgc tcagatggga    240

cagccctggt gcttcttccc accctcctac cccagctaca agctggaaaa cctgagcagc    300

agcgagatgg gctacaccgc caccctgacc agaaccaccc ccacattctt cccaaaggac    360

atcctgaccc tgcggctgga cgtgatgatg gaaaccgaga accggctgca cttcaccatc    420

aaggaccccg ccaatcggag atacgaggtg cccctggaaa ccccccacgt gcactctaga    480

gcccccagcc ctctgtacag cgtggaattc agcgaggaac ccttcggcgt gatcgtgcgg    540

agacagctgg atggcagagt gctgctgaac accaccgtgg cccctctgtt cttcgccgac    600

cagttcctgc agctgagcac cagcctgccc agccagtaca tcacaggact ggccgagcac    660

ctgagccccc tgatgctgag cacatcctgg acccggatca ccctgtggaa cagggatctg    720

gcccctaccc ctggcgccaa tctgtacggc agccaccctt tctacctggc cctggaagat    780

ggcggatctg cccacggagt gtttctgctg aactccaacg ccatggacgt ggtgctgcag    840

cctagccctg ccctgtcttg gagaagcaca ggcggcatcc tggatgtgta catctttctg    900

ggccccgagc ccaagagcgt ggtgcagcag tatctggatg tcgtgggcta ccccttcatg    960

cccccttact ggggcctggg attccacctg tgcagatggg gctactccag caccgccatc   1020

accagacagg tggtggaaaa catgaccaga gcccacttcc cactggatgt gcagtggaac   1080

gacctggact acatggacag cagacgggac ttcaccttca acaaggacgg cttccgggac   1140

ttccccgcca tggtgcagga actgcatcag ggcggcagac ggtacatgat gatcgtggat   1200

cccgccatca gctcctctgg ccctgccggc tcttacagac cctacgacga gggcctgcgg   1260

agaggcgtgt tcatcaccaa cgagacaggc cagcccctga tcggcaaagt gtggcctggc   1320

agcacagcct tccccgactt caccaatcct accgccctgg cttggtggga ggacatggtg   1380

gccgagttcc acgaccaggt gcccttcgac ggcatgtgga tcgacatgaa cgagcccagc   1440

aacttcatcc ggggcagcga ggatggctgc cccaacaacg aactggaaaa tcccccttac   1500

gtgcccggcg tcgtgggcgg aacactgcag gccgctacaa tctgtgccag cagccaccag   1560

tttctgagca cccactacaa cctgcacaac ctgtacggcc tgaccgaggc cattgccagc   1620

caccgcgctc tcgtgaaagc cagaggcaca cggcccttcg tgatcagcag aagcaccttt   1680

gccggccacg gcagatacgc cggacattgg actggcgacg tgtggtcctc ttgggagcag   1740

ctggcctcta gcgtgcccga gatcctgcag ttcaatctgc tgggcgtgcc actcgtgggc   1800

gccgatgtgt gtggcttcct gggcaacacc tccgaggaac tgtgtgtgcg gtggacacag   1860

ctgggcgcct tctacccttt catgagaaac cacaacagcc tgctgagcct gccccaggaa   1920

ccctacagct ttagcgagcc tgcacagcag gccatgcgga aggccctgac actgagatac   1980

gctctgctgc cccacctgta caccctgttt caccaggccc atgtggccgg cgagacagtg   2040

gccagacctc tgtttctgga attccccaag gacagcagca cctggaccgt ggaccatcag   2100

ctgctgtggg gagaggctct gctgattacc ccagtgctgc aggcaggcaa ggccgaagtg   2160

accggctact ttcccctggg cacttggtac gacctgcaga ccgtgcctgt ggaagccctg   2220

ggatctctgc ctccacctcc tgccgctcct agagagcctg ccattcactc tgagggccag   2280

tgggtcacac tgcctgcccc cctggatacc atcaacgtgc acctgagggc cggctacatc   2340

ataccactgc agggacctgg cctgaccacc accgagtcta gacagcagcc aatggccctg   2400

gccgtggccc tgaccaaagg cggagaagct aggggcgagc tgttctggga cgatggcgag   2460

agcctggaag tgctggaaag aggcgcctat acccaagtga tcttcctggc ccggaacaac   2520

accatcgtga acgagctggt gcgcgtgacc tctgaaggcg ctggactgca gctgcagaaa   2580

gtgaccgtgc tgggagtggc cacagcccct cagcaggtgc tgtctaatgg cgtgcccgtg   2640

tccaacttca cctacagccc cgacaccaag gtgctggaca tctgcgtgtc actgctgatg   2700

ggagagcagt ttctggtgtc ctggtgctga                                    2730


<210>  41
<211>  4258
<212>  DNA
<213>  artificial

<220>
<223>  ApoE-hAAT-modified HBB2 intron-sp7-Spadin- D42-hGAAco1-bgHpolyA

<400>  41
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag    360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc    420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact    480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag    540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg    600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta    660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac    720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc    780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat    840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat    900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat    960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt   1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta   1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg   1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat   1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca   1260

ctttggcaaa gcacgcgtgc caccatggcc tttctgtggc tgctgagctg ttgggccctg   1320

ctgggcacca ccttcggcgc tccacttcct cgttggagtg gccctatcgg agtgtcttgg   1380

ggactgagag gcgcgccggc ccaccccggc agacctagag ctgtgcctac ccagtgtgac   1440

gtgcccccca acagcagatt cgactgcgcc cctgacaagg ccatcaccca ggaacagtgc   1500

gaggccagag gctgctgcta catccctgcc aagcagggac tgcagggcgc tcagatggga   1560

cagccctggt gcttcttccc accctcctac cccagctaca agctggaaaa cctgagcagc   1620

agcgagatgg gctacaccgc caccctgacc agaaccaccc ccacattctt cccaaaggac   1680

atcctgaccc tgcggctgga cgtgatgatg gaaaccgaga accggctgca cttcaccatc   1740

aaggaccccg ccaatcggag atacgaggtg cccctggaaa ccccccacgt gcactctaga   1800

gcccccagcc ctctgtacag cgtggaattc agcgaggaac ccttcggcgt gatcgtgcgg   1860

agacagctgg atggcagagt gctgctgaac accaccgtgg cccctctgtt cttcgccgac   1920

cagttcctgc agctgagcac cagcctgccc agccagtaca tcacaggact ggccgagcac   1980

ctgagccccc tgatgctgag cacatcctgg acccggatca ccctgtggaa cagggatctg   2040

gcccctaccc ctggcgccaa tctgtacggc agccaccctt tctacctggc cctggaagat   2100

ggcggatctg cccacggagt gtttctgctg aactccaacg ccatggacgt ggtgctgcag   2160

cctagccctg ccctgtcttg gagaagcaca ggcggcatcc tggatgtgta catctttctg   2220

ggccccgagc ccaagagcgt ggtgcagcag tatctggatg tcgtgggcta ccccttcatg   2280

cccccttact ggggcctggg attccacctg tgcagatggg gctactccag caccgccatc   2340

accagacagg tggtggaaaa catgaccaga gcccacttcc cactggatgt gcagtggaac   2400

gacctggact acatggacag cagacgggac ttcaccttca acaaggacgg cttccgggac   2460

ttccccgcca tggtgcagga actgcatcag ggcggcagac ggtacatgat gatcgtggat   2520

cccgccatca gctcctctgg ccctgccggc tcttacagac cctacgacga gggcctgcgg   2580

agaggcgtgt tcatcaccaa cgagacaggc cagcccctga tcggcaaagt gtggcctggc   2640

agcacagcct tccccgactt caccaatcct accgccctgg cttggtggga ggacatggtg   2700

gccgagttcc acgaccaggt gcccttcgac ggcatgtgga tcgacatgaa cgagcccagc   2760

aacttcatcc ggggcagcga ggatggctgc cccaacaacg aactggaaaa tcccccttac   2820

gtgcccggcg tcgtgggcgg aacactgcag gccgctacaa tctgtgccag cagccaccag   2880

tttctgagca cccactacaa cctgcacaac ctgtacggcc tgaccgaggc cattgccagc   2940

caccgcgctc tcgtgaaagc cagaggcaca cggcccttcg tgatcagcag aagcaccttt   3000

gccggccacg gcagatacgc cggacattgg actggcgacg tgtggtcctc ttgggagcag   3060

ctggcctcta gcgtgcccga gatcctgcag ttcaatctgc tgggcgtgcc actcgtgggc   3120

gccgatgtgt gtggcttcct gggcaacacc tccgaggaac tgtgtgtgcg gtggacacag   3180

ctgggcgcct tctacccttt catgagaaac cacaacagcc tgctgagcct gccccaggaa   3240

ccctacagct ttagcgagcc tgcacagcag gccatgcgga aggccctgac actgagatac   3300

gctctgctgc cccacctgta caccctgttt caccaggccc atgtggccgg cgagacagtg   3360

gccagacctc tgtttctgga attccccaag gacagcagca cctggaccgt ggaccatcag   3420

ctgctgtggg gagaggctct gctgattacc ccagtgctgc aggcaggcaa ggccgaagtg   3480

accggctact ttcccctggg cacttggtac gacctgcaga ccgtgcctgt ggaagccctg   3540

ggatctctgc ctccacctcc tgccgctcct agagagcctg ccattcactc tgagggccag   3600

tgggtcacac tgcctgcccc cctggatacc atcaacgtgc acctgagggc cggctacatc   3660

ataccactgc agggacctgg cctgaccacc accgagtcta gacagcagcc aatggccctg   3720

gccgtggccc tgaccaaagg cggagaagct aggggcgagc tgttctggga cgatggcgag   3780

agcctggaag tgctggaaag aggcgcctat acccaagtga tcttcctggc ccggaacaac   3840

accatcgtga acgagctggt gcgcgtgacc tctgaaggcg ctggactgca gctgcagaaa   3900

gtgaccgtgc tgggagtggc cacagcccct cagcaggtgc tgtctaatgg cgtgcccgtg   3960

tccaacttca cctacagccc cgacaccaag gtgctggaca tctgcgtgtc actgctgatg   4020

ggagagcagt ttctggtgtc ctggtgctga ctcgagagat ctaccggtga attcaccgcg   4080

ggtttaaact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc   4140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc   4200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtgggggcta gctctaga     4258


<210>  42
<211>  4246
<212>  DNA
<213>  artificial

<220>
<223>  ApoE-hAAT-modified HBB2 intron-sp7-HD-NT1-13- 
       D42-hGAAco1-bgHpolyA

<400>  42
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag    360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc    420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact    480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag    540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg    600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta    660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac    720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc    780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat    840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat    900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat    960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt   1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta   1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg   1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat   1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca   1260

ctttggcaaa gcacgcgtgc caccatggcc tttctgtggc tgctgagctg ttgggccctg   1320

ctgggcacca ccttcggcca gctgtacgag aacaagccca gacggcccta catcctgggc   1380

gcgccggccc accccggcag acctagagct gtgcctaccc agtgtgacgt gccccccaac   1440

agcagattcg actgcgcccc tgacaaggcc atcacccagg aacagtgcga ggccagaggc   1500

tgctgctaca tccctgccaa gcagggactg cagggcgctc agatgggaca gccctggtgc   1560

ttcttcccac cctcctaccc cagctacaag ctggaaaacc tgagcagcag cgagatgggc   1620

tacaccgcca ccctgaccag aaccaccccc acattcttcc caaaggacat cctgaccctg   1680

cggctggacg tgatgatgga aaccgagaac cggctgcact tcaccatcaa ggaccccgcc   1740

aatcggagat acgaggtgcc cctggaaacc ccccacgtgc actctagagc ccccagccct   1800

ctgtacagcg tggaattcag cgaggaaccc ttcggcgtga tcgtgcggag acagctggat   1860

ggcagagtgc tgctgaacac caccgtggcc cctctgttct tcgccgacca gttcctgcag   1920

ctgagcacca gcctgcccag ccagtacatc acaggactgg ccgagcacct gagccccctg   1980

atgctgagca catcctggac ccggatcacc ctgtggaaca gggatctggc ccctacccct   2040

ggcgccaatc tgtacggcag ccaccctttc tacctggccc tggaagatgg cggatctgcc   2100

cacggagtgt ttctgctgaa ctccaacgcc atggacgtgg tgctgcagcc tagccctgcc   2160

ctgtcttgga gaagcacagg cggcatcctg gatgtgtaca tctttctggg ccccgagccc   2220

aagagcgtgg tgcagcagta tctggatgtc gtgggctacc ccttcatgcc cccttactgg   2280

ggcctgggat tccacctgtg cagatggggc tactccagca ccgccatcac cagacaggtg   2340

gtggaaaaca tgaccagagc ccacttccca ctggatgtgc agtggaacga cctggactac   2400

atggacagca gacgggactt caccttcaac aaggacggct tccgggactt ccccgccatg   2460

gtgcaggaac tgcatcaggg cggcagacgg tacatgatga tcgtggatcc cgccatcagc   2520

tcctctggcc ctgccggctc ttacagaccc tacgacgagg gcctgcggag aggcgtgttc   2580

atcaccaacg agacaggcca gcccctgatc ggcaaagtgt ggcctggcag cacagccttc   2640

cccgacttca ccaatcctac cgccctggct tggtgggagg acatggtggc cgagttccac   2700

gaccaggtgc ccttcgacgg catgtggatc gacatgaacg agcccagcaa cttcatccgg   2760

ggcagcgagg atggctgccc caacaacgaa ctggaaaatc ccccttacgt gcccggcgtc   2820

gtgggcggaa cactgcaggc cgctacaatc tgtgccagca gccaccagtt tctgagcacc   2880

cactacaacc tgcacaacct gtacggcctg accgaggcca ttgccagcca ccgcgctctc   2940

gtgaaagcca gaggcacacg gcccttcgtg atcagcagaa gcacctttgc cggccacggc   3000

agatacgccg gacattggac tggcgacgtg tggtcctctt gggagcagct ggcctctagc   3060

gtgcccgaga tcctgcagtt caatctgctg ggcgtgccac tcgtgggcgc cgatgtgtgt   3120

ggcttcctgg gcaacacctc cgaggaactg tgtgtgcggt ggacacagct gggcgccttc   3180

taccctttca tgagaaacca caacagcctg ctgagcctgc cccaggaacc ctacagcttt   3240

agcgagcctg cacagcaggc catgcggaag gccctgacac tgagatacgc tctgctgccc   3300

cacctgtaca ccctgtttca ccaggcccat gtggccggcg agacagtggc cagacctctg   3360

tttctggaat tccccaagga cagcagcacc tggaccgtgg accatcagct gctgtgggga   3420

gaggctctgc tgattacccc agtgctgcag gcaggcaagg ccgaagtgac cggctacttt   3480

cccctgggca cttggtacga cctgcagacc gtgcctgtgg aagccctggg atctctgcct   3540

ccacctcctg ccgctcctag agagcctgcc attcactctg agggccagtg ggtcacactg   3600

cctgcccccc tggataccat caacgtgcac ctgagggccg gctacatcat accactgcag   3660

ggacctggcc tgaccaccac cgagtctaga cagcagccaa tggccctggc cgtggccctg   3720

accaaaggcg gagaagctag gggcgagctg ttctgggacg atggcgagag cctggaagtg   3780

ctggaaagag gcgcctatac ccaagtgatc ttcctggccc ggaacaacac catcgtgaac   3840

gagctggtgc gcgtgacctc tgaaggcgct ggactgcagc tgcagaaagt gaccgtgctg   3900

ggagtggcca cagcccctca gcaggtgctg tctaatggcg tgcccgtgtc caacttcacc   3960

tacagccccg acaccaaggt gctggacatc tgcgtgtcac tgctgatggg agagcagttt   4020

ctggtgtcct ggtgctgact cgagagatct accggtgaat tcaccgcggg tttaaactgt   4080

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga   4140

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag   4200

taggtgtcat tctattctgg ggggtggggt gggggctagc tctaga                  4246


<210>  43
<211>  4222
<212>  DNA
<213>  artificial

<220>
<223>  ApoE-hAAT-modified HBB2 intron-sp7-HD-NT9-13- 
       D42-hGAAco1-bgHpolyA

<400>  43
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc     60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc    120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc    180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc    240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt    300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag    360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc    420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact    480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag    540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg    600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta    660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac    720

agtgaataga tcctgagaac ttcagggtga gtctatggga cccttgatgt tttctttccc    780

cttcttttct atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat    840

tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat    900

acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat    960

gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt   1020

taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta   1080

agaggtttca tattgctaat agcagctaca atccagctac cattctgctt ttattttctg   1140

gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcttgttcat   1200

acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc tggcccatca   1260

ctttggcaaa gcacgcgtgc caccatggcc tttctgtggc tgctgagctg ttgggccctg   1320

ctgggcacca ccttcggccg gccctacatc ctgggcgcgc cggcccaccc cggcagacct   1380

agagctgtgc ctacccagtg tgacgtgccc cccaacagca gattcgactg cgcccctgac   1440

aaggccatca cccaggaaca gtgcgaggcc agaggctgct gctacatccc tgccaagcag   1500

ggactgcagg gcgctcagat gggacagccc tggtgcttct tcccaccctc ctaccccagc   1560

tacaagctgg aaaacctgag cagcagcgag atgggctaca ccgccaccct gaccagaacc   1620

acccccacat tcttcccaaa ggacatcctg accctgcggc tggacgtgat gatggaaacc   1680

gagaaccggc tgcacttcac catcaaggac cccgccaatc ggagatacga ggtgcccctg   1740

gaaacccccc acgtgcactc tagagccccc agccctctgt acagcgtgga attcagcgag   1800

gaacccttcg gcgtgatcgt gcggagacag ctggatggca gagtgctgct gaacaccacc   1860

gtggcccctc tgttcttcgc cgaccagttc ctgcagctga gcaccagcct gcccagccag   1920

tacatcacag gactggccga gcacctgagc cccctgatgc tgagcacatc ctggacccgg   1980

atcaccctgt ggaacaggga tctggcccct acccctggcg ccaatctgta cggcagccac   2040

cctttctacc tggccctgga agatggcgga tctgcccacg gagtgtttct gctgaactcc   2100

aacgccatgg acgtggtgct gcagcctagc cctgccctgt cttggagaag cacaggcggc   2160

atcctggatg tgtacatctt tctgggcccc gagcccaaga gcgtggtgca gcagtatctg   2220

gatgtcgtgg gctacccctt catgccccct tactggggcc tgggattcca cctgtgcaga   2280

tggggctact ccagcaccgc catcaccaga caggtggtgg aaaacatgac cagagcccac   2340

ttcccactgg atgtgcagtg gaacgacctg gactacatgg acagcagacg ggacttcacc   2400

ttcaacaagg acggcttccg ggacttcccc gccatggtgc aggaactgca tcagggcggc   2460

agacggtaca tgatgatcgt ggatcccgcc atcagctcct ctggccctgc cggctcttac   2520

agaccctacg acgagggcct gcggagaggc gtgttcatca ccaacgagac aggccagccc   2580

ctgatcggca aagtgtggcc tggcagcaca gccttccccg acttcaccaa tcctaccgcc   2640

ctggcttggt gggaggacat ggtggccgag ttccacgacc aggtgccctt cgacggcatg   2700

tggatcgaca tgaacgagcc cagcaacttc atccggggca gcgaggatgg ctgccccaac   2760

aacgaactgg aaaatccccc ttacgtgccc ggcgtcgtgg gcggaacact gcaggccgct   2820

acaatctgtg ccagcagcca ccagtttctg agcacccact acaacctgca caacctgtac   2880

ggcctgaccg aggccattgc cagccaccgc gctctcgtga aagccagagg cacacggccc   2940

ttcgtgatca gcagaagcac ctttgccggc cacggcagat acgccggaca ttggactggc   3000

gacgtgtggt cctcttggga gcagctggcc tctagcgtgc ccgagatcct gcagttcaat   3060

ctgctgggcg tgccactcgt gggcgccgat gtgtgtggct tcctgggcaa cacctccgag   3120

gaactgtgtg tgcggtggac acagctgggc gccttctacc ctttcatgag aaaccacaac   3180

agcctgctga gcctgcccca ggaaccctac agctttagcg agcctgcaca gcaggccatg   3240

cggaaggccc tgacactgag atacgctctg ctgccccacc tgtacaccct gtttcaccag   3300

gcccatgtgg ccggcgagac agtggccaga cctctgtttc tggaattccc caaggacagc   3360

agcacctgga ccgtggacca tcagctgctg tggggagagg ctctgctgat taccccagtg   3420

ctgcaggcag gcaaggccga agtgaccggc tactttcccc tgggcacttg gtacgacctg   3480

cagaccgtgc ctgtggaagc cctgggatct ctgcctccac ctcctgccgc tcctagagag   3540

cctgccattc actctgaggg ccagtgggtc acactgcctg cccccctgga taccatcaac   3600

gtgcacctga gggccggcta catcatacca ctgcagggac ctggcctgac caccaccgag   3660

tctagacagc agccaatggc cctggccgtg gccctgacca aaggcggaga agctaggggc   3720

gagctgttct gggacgatgg cgagagcctg gaagtgctgg aaagaggcgc ctatacccaa   3780

gtgatcttcc tggcccggaa caacaccatc gtgaacgagc tggtgcgcgt gacctctgaa   3840

ggcgctggac tgcagctgca gaaagtgacc gtgctgggag tggccacagc ccctcagcag   3900

gtgctgtcta atggcgtgcc cgtgtccaac ttcacctaca gccccgacac caaggtgctg   3960

gacatctgcg tgtcactgct gatgggagag cagtttctgg tgtcctggtg ctgactcgag   4020

agatctaccg gtgaattcac cgcgggttta aactgtgcct tctagttgcc agccatctgt   4080

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc   4140

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg   4200

tggggtgggg gctagctcta ga                                            4222


<210>  44
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  Primer BGH polyA forward

<400>  44
tctagttgcc agccatctgt tgt                                             23


<210>  45
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  45 Primer BGH polyA Reverse

<400>  45
tgggagtggc accttcca                                                   18


<210>  46
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Primer codon-optimized hGAA forward

<400>  46
agatacgccg gacattggac tg                                              22


<210>  47
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Primer codon-optimized hGAA reverse

<400>  47
gcacgcccag cagattgaac                                                 20


<210>  48
<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  48

Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  49
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  49

Gly Ser Gly Ser Gly Ser 
1               5       


<210>  50
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  50

Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210>  51
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  51

Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 
1               5                   10      


<210>  52
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  52

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10      


<210>  53
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  53

Gly Gly Ser Gly Gly 
1               5   


<210>  54
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  54

Gly Gly Ser Gly Gly Gly Gly Gly 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  55

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  56
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  56

Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  57
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  57

Ala Ala Gly Ala Ala Thr Ala 
1               5           


<210>  58
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  58

Gly Gly Gly Gly Gly 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  59

Gly Gly Ser Ser Gly 
1               5   


<210>  60
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  60

Gly Ser Gly Gly Gly Thr Gly Gly Gly Ser Gly 
1               5                   10      


<210>  61
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  61

Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly 
1               5                   10          


<210>  62
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  62

Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  


<210>  63
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  63

Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  


<210>  64
<211>  2
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  64

Gly Thr 
1       


<210>  65
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  linker

<400>  65

Gly Ala Pro 
1           


<210>  66
<211>  917
<212>  PRT
<213>  artificial

<220>
<223>  delta8-GAA

<400>  66

Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val Leu Glu Glu 
1               5                   10                  15      


Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly Pro Arg Asp 
            20                  25                  30          


Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp 
        35                  40                  45              


Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr 
    50                  55                  60                  


Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln 
65                  70                  75                  80  


Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro 
                85                  90                  95      


Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly 
            100                 105                 110         


Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp 
        115                 120                 125             


Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu 
    130                 135                 140                 


His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu 
145                 150                 155                 160 


Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val 
                165                 170                 175     


Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp 
            180                 185                 190         


Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp 
        195                 200                 205             


Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly 
    210                 215                 220                 


Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg 
225                 230                 235                 240 


Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu 
                245                 250                 255     


Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala 
            260                 265                 270         


His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln 
        275                 280                 285             


Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val 
    290                 295                 300                 


Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu 
305                 310                 315                 320 


Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe 
                325                 330                 335     


His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val 
            340                 345                 350         


Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn 
        355                 360                 365             


Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp 
    370                 375                 380                 


Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly 
385                 390                 395                 400 


Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro 
                405                 410                 415     


Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe 
            420                 425                 430         


Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly 
        435                 440                 445             


Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp 
    450                 455                 460                 


Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met 
465                 470                 475                 480 


Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp 
                485                 490                 495     


Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val 
            500                 505                 510         


Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln 
        515                 520                 525             


Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu 
    530                 535                 540                 


Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro 
545                 550                 555                 560 


Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly 
                565                 570                 575     


His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser 
            580                 585                 590         


Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly 
        595                 600                 605             


Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val 
    610                 615                 620                 


Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn 
625                 630                 635                 640 


Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala 
                645                 650                 655     


Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro 
            660                 665                 670         


His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val 
        675                 680                 685             


Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr 
    690                 695                 700                 


Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val 
705                 710                 715                 720 


Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr 
                725                 730                 735     


Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro 
            740                 745                 750         


Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln 
        755                 760                 765             


Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg 
    770                 775                 780                 


Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu 
785                 790                 795                 800 


Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly 
                805                 810                 815     


Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val 
            820                 825                 830         


Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn 
        835                 840                 845             


Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu 
    850                 855                 860                 


Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln 
865                 870                 875                 880 


Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp 
                885                 890                 895     


Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe 
            900                 905                 910         


Leu Val Ser Trp Cys 
        915         


<210>  67
<211>  896
<212>  PRT
<213>  artificial

<220>
<223>  delta29-GAA

<400>  67

Gln Gln Gly Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro 
1               5                   10                  15      


Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser 
            20                  25                  30          


Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu 
        35                  40                  45              


Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala 
    50                  55                  60                  


Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr 
65                  70                  75                  80  


Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu 
                85                  90                  95      


Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg 
            100                 105                 110         


Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys 
        115                 120                 125             


Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val 
    130                 135                 140                 


His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu 
145                 150                 155                 160 


Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu 
                165                 170                 175     


Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu 
            180                 185                 190         


Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu 
        195                 200                 205             


Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn 
    210                 215                 220                 


Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro 
225                 230                 235                 240 


Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu 
                245                 250                 255     


Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu 
            260                 265                 270         


Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly 
        275                 280                 285             


Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr 
    290                 295                 300                 


Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp 
305                 310                 315                 320 


Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr 
                325                 330                 335     


Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met 
            340                 345                 350         


Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe 
        355                 360                 365             


Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met 
    370                 375                 380                 


Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg 
385                 390                 395                 400 


Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr 
                405                 410                 415     


Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro 
            420                 425                 430         


Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala 
        435                 440                 445             


Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn 
    450                 455                 460                 


Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn 
465                 470                 475                 480 


Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu 
                485                 490                 495     


Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His 
            500                 505                 510         


Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His 
        515                 520                 525             


Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg 
    530                 535                 540                 


Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp 
545                 550                 555                 560 


Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu 
                565                 570                 575     


Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly 
            580                 585                 590         


Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu 
        595                 600                 605             


Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu 
    610                 615                 620                 


Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg 
625                 630                 635                 640 


Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu 
                645                 650                 655     


Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe 
            660                 665                 670         


Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu 
        675                 680                 685             


Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys 
    690                 695                 700                 


Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln 
705                 710                 715                 720 


Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala 
                725                 730                 735     


Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro 
            740                 745                 750         


Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile 
        755                 760                 765             


Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro 
    770                 775                 780                 


Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu 
785                 790                 795                 800 


Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala 
                805                 810                 815     


Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu 
            820                 825                 830         


Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val 
        835                 840                 845             


Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly 
    850                 855                 860                 


Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp 
865                 870                 875                 880 


Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
                885                 890                 895     


<210>  68
<211>  882
<212>  PRT
<213>  artificial

<220>
<223>  delta43-GAA

<400>  68

His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro 
1               5                   10                  15      


Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln 
            20                  25                  30          


Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln 
        35                  40                  45              


Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro 
    50                  55                  60                  


Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala 
65                  70                  75                  80  


Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr 
                85                  90                  95      


Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr 
            100                 105                 110         


Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro 
        115                 120                 125             


His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser 
    130                 135                 140                 


Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val 
145                 150                 155                 160 


Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu 
                165                 170                 175     


Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu 
            180                 185                 190         


His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu 
        195                 200                 205             


Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser 
    210                 215                 220                 


His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val 
225                 230                 235                 240 


Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro 
                245                 250                 255     


Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe 
            260                 265                 270         


Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val 
        275                 280                 285             


Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys 
    290                 295                 300                 


Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn 
305                 310                 315                 320 


Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp 
                325                 330                 335     


Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg 
            340                 345                 350         


Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr 
        355                 360                 365             


Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser 
    370                 375                 380                 


Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn 
385                 390                 395                 400 


Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala 
                405                 410                 415     


Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met 
            420                 425                 430         


Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp 
        435                 440                 445             


Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro 
    450                 455                 460                 


Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly 
465                 470                 475                 480 


Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser 
                485                 490                 495     


Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala 
            500                 505                 510         


Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile 
        515                 520                 525             


Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr 
    530                 535                 540                 


Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu 
545                 550                 555                 560 


Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val 
                565                 570                 575     


Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr 
            580                 585                 590         


Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu 
        595                 600                 605             


Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala 
    610                 615                 620                 


Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr 
625                 630                 635                 640 


Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro 
                645                 650                 655     


Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His 
            660                 665                 670         


Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala 
        675                 680                 685             


Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp 
    690                 695                 700                 


Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro 
705                 710                 715                 720 


Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr 
                725                 730                 735     


Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr 
            740                 745                 750         


Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln 
        755                 760                 765             


Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg 
    770                 775                 780                 


Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg 
785                 790                 795                 800 


Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val 
                805                 810                 815     


Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln 
            820                 825                 830         


Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser 
        835                 840                 845             


Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val 
    850                 855                 860                 


Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser 
865                 870                 875                 880 


Trp Cys 
        


<210>  69
<211>  878
<212>  PRT
<213>  artificial

<220>
<223>  delta47-GAA

<400>  69

Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe 
1               5                   10                  15      


Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg 
            20                  25                  30          


Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met 
        35                  40                  45              


Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu 
    50                  55                  60                  


Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg 
65                  70                  75                  80  


Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp 
                85                  90                  95      


Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro 
            100                 105                 110         


Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser 
        115                 120                 125             


Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe 
    130                 135                 140                 


Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr 
145                 150                 155                 160 


Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr 
                165                 170                 175     


Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro 
            180                 185                 190         


Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp 
        195                 200                 205             


Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr 
    210                 215                 220                 


Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn 
225                 230                 235                 240 


Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp 
                245                 250                 255     


Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu 
            260                 265                 270         


Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe 
        275                 280                 285             


Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr 
    290                 295                 300                 


Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala 
305                 310                 315                 320 


His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser 
                325                 330                 335     


Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala 
            340                 345                 350         


Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val 
        355                 360                 365             


Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr 
    370                 375                 380                 


Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln 
385                 390                 395                 400 


Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe 
                405                 410                 415     


Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe 
            420                 425                 430         


His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro 
        435                 440                 445             


Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu 
    450                 455                 460                 


Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala 
465                 470                 475                 480 


Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn 
                485                 490                 495     


Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala 
            500                 505                 510         


Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr 
        515                 520                 525             


Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp 
    530                 535                 540                 


Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe 
545                 550                 555                 560 


Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu 
                565                 570                 575     


Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala 
            580                 585                 590         


Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln 
        595                 600                 605             


Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala 
    610                 615                 620                 


Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His 
625                 630                 635                 640 


Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu 
                645                 650                 655     


Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp 
            660                 665                 670         


Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu 
        675                 680                 685             


Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val 
    690                 695                 700                 


Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg 
705                 710                 715                 720 


Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro 
                725                 730                 735     


Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu 
            740                 745                 750         


Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala 
        755                 760                 765             


Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe 
    770                 775                 780                 


Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr 
785                 790                 795                 800 


Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val 
                805                 810                 815     


Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val 
            820                 825                 830         


Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro 
        835                 840                 845             


Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys 
    850                 855                 860                 


Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
865                 870                 875             


