                         SEQUENCE LISTING

<110>  VIB VZW
       VRIJE UNIVERSITEIT BRUSSEL
       UNITED KINGDOM RESEARCH AND INNOVATION
 
<120>  NANODISC-SPECIFIC ANTIGEN-BINDING CHIMERIC PROTEINS

<130>  JaSt/MSPMbs/667

<150>  EP 19204412.1
<151>  2019-10-21

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His6-TEV-MSP1D1 (CA15914)

<400>  1

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 
    130                 135                 140                 


Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 
145                 150                 155                 160 


Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 
                165                 170                 175     


Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 
            180                 185                 190         


Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 
        195                 200                 205             


Leu Asn Thr Gln 
    210         


<210>  2
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His6-TEV-MSP2N2 (CA15915)

<400>  2

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg Leu Ala 
    130                 135                 140                 


Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu Ala Glu 
145                 150                 155                 160 


Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu Lys Ala 
                165                 170                 175     


Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val Leu Glu 
            180                 185                 190         


Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr Lys Lys 
        195                 200                 205             


Leu Asn Thr Gln Gly Thr Pro Val Thr Gln Glu Phe Trp Asp Asn Leu 
    210                 215                 220                 


Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu 
225                 230                 235                 240 


Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys 
                245                 250                 255     


Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg 
            260                 265                 270         


Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu 
        275                 280                 285             


Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His 
    290                 295                 300                 


Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg 
305                 310                 315                 320 


Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala 
                325                 330                 335     


Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu 
            340                 345                 350         


Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu 
        355                 360                 365             


Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu 
    370                 375                 380                 


Tyr Thr Lys Lys Leu Asn Thr Gln 
385                 390         


<210>  3
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_B9 Nanobody (CA15883)

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Cys Ser Ile 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Ala Pro Tyr Ser Ser Trp Ser Arg Gly Leu Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His His 
        115                 120                 125             


His His Glu Pro Glu Ala 
    130                 


<210>  4
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_G9 Nanobody (CA15884)

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Trp Asn Ser Ile Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Ser Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Arg Gly Leu Gly Gln Thr Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser His His His His His His Glu Pro Glu Ala 
        115                 120                 125         


<210>  5
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_A12 Nanobody (CA15885)

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Ala Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ala Arg Thr Gly Ser Gly Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Gly Gly Ser Leu Ala Thr Ile Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser His His His His His His Glu Pro Glu 
        115                 120                 125             


Ala 
    


<210>  6
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_B7 Nanobody (CA15886)

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Ala Gly Ile Thr Gly Thr Ala Gly Ile Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Leu Thr Ser Tyr Ala Gly Arg Gly Ala Ala Gly Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His His 
        115                 120                 125             


His His Glu Pro Glu Ala 
    130                 


<210>  7
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_E8 Nanobody (CA15887)

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Glu Arg Thr Phe Ser Ser His 
            20                  25                  30          


His Met Ala Trp Phe Arg Gln Ala Pro Gly Met Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Phe Gly Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Gly Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Met Pro Thr Tyr Arg Gly Arg Lys Tyr Tyr Leu Ala Asp Asp 
            100                 105                 110         


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His 
        115                 120                 125             


His His His His Glu Pro Glu Ala 
    130                 135     


<210>  8
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_B9 Nanobody (CA15888)

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Arg Ser Ala Arg Thr Phe Gly Ser Val 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Thr Ala Ile Asp Trp Ser Gly Ser Asn Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Arg Arg Val Val Val Thr Thr Ser Asp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His His His His 
        115                 120                 125             


Glu Pro Glu Ala 
    130         


<210>  9
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_E4 Nanobody (CA15889)

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Gly Ser Thr 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ser Ile Thr Trp Asn Arg Gly Leu Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Leu Gly Met Gly Thr Ser Phe Ala Ser Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser His His His His His His Glu Pro Glu Ala 
        115                 120                 125         


<210>  10
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_H5 Nanobody (CA15890)

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Leu Thr Asp Gly Gly Thr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Pro Ser Asp Gly Tyr Ser Gly Gly Tyr Arg Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser His His His His His His Glu Pro 
        115                 120                 125             


Glu Ala 
    130 


<210>  11
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_C10 Nanobody (CA15891)

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Arg Thr Ser Gly Ser Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Ala Ala Ile Ser Phe Thr Ala Gly Val Thr Tyr Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Pro Ser Leu Val Leu Ile Leu Thr Ala Lys Pro Asn Ile 
            100                 105                 110         


Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His 
        115                 120                 125             


His His His Glu Pro Glu Ala 
    130                 135 


<210>  12
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_A5 Nanobody (CA15892)

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asn Ser 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Ala Trp Ile Ile Thr His Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn His Leu Lys Pro Glu Asp Ala Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gln Gly Tyr Asp Gly Tyr Val Pro Ser Arg Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His His His His 
        115                 120                 125             


Glu Pro Glu Ala 
    130         


<210>  13
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_B4 Nanobody (CA15893)

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Ser Phe Phe Asn Ile Tyr 
            20                  25                  30          


Asp Leu Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Lys Val Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Val Ser Pro Gly Gly Val Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser His His His His His His Glu Pro Glu Ala 
        115                 120                 125         


<210>  14
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_F3 Nanobody (CA15894)

<400>  14

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe Gly Pro Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Arg Ile Gly Asn Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Leu Ser Arg Glu Ile Ala Val Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Asn Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Ala Lys Tyr Gly Val Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser His His His His His His Glu Pro Glu Ala 
        115                 120                 125 


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_B1 Nanobody (CA15895)

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Ile Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Pro Gly Gly Arg Ile Thr Tyr Ala Val Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr Leu Ser Leu 
65                  70                  75                  80  


Gln Met Asn Glu Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Arg Leu Gly Glu Lys Gly Gln Gly Thr Gln Val Thr Val Ser Ser His 
            100                 105                 110         


His His His His His Glu Pro Glu Ala 
        115                 120     


<210>  16
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_E1 Nanobody (CA15896)

<400>  16

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Thr Arg Ser Pro 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Arg Gln Arg Glu Trp Val 
        35                  40                  45              


Thr Ser Ile Leu Gly Thr Gly Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Thr Val Leu Asn Gly Arg Pro Ser Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser His His His His His His Glu Pro Glu Ala 
        115                 120                 125 


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved  beta-strand A of a Nanobody

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10              


<210>  18
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circularly permutated c7HopQ variant of Helicobacter pylori 
       strain G27 HopQ adhesin domain protein

<400>  18

Thr Lys Thr Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn 
1               5                   10                  15      


Leu Leu Thr Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys 
            20                  25                  30          


Pro Ile Leu Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn 
        35                  40                  45              


Ala Asn Thr Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys 
    50                  55                  60                  


Ala Thr Phe Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn 
65                  70                  75                  80  


Ala Gln Lys Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro 
                85                  90                  95      


Lys Asn Ile Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser 
            100                 105                 110         


Leu Thr Ala Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala 
        115                 120                 125             


Glu Ile Leu Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu 
    130                 135                 140                 


Ser Ser Gly His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala 
145                 150                 155                 160 


Ile Ser Ser Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly 
                165                 170                 175     


Asn Gly Cys Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser 
            180                 185                 190         


Ala Ala Asp Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn 
        195                 200                 205             


Leu Ala Asn Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln 
    210                 215                 220                 


Leu Ser Arg Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser 
225                 230                 235                 240 


Ala Gln Ala Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys 
                245                 250                 255     


Thr Leu Ala Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu 
            260                 265                 270         


Leu Ala Leu Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala 
        275                 280                 285             


Val Ile Cys Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys 
    290                 295                 300                 


Asp Phe His Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys 
305                 310                 315                 320 


Gly Gly Ser Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn 
                325                 330                 335     


Thr Leu Lys Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu 
            340                 345                 350         


Lys Ile His Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala 
        355                 360                 365             


Gly Leu Ala Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val 
    370                 375                 380                 


Thr Thr Ser Lys Tyr 
385                 


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved beta -strand B of a Nanobody

<400>  19

Gly Ser Leu Arg Leu Ser Cys 
1               5           


<210>  20
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNb1_B9c7HopQ MegaBody (CA15898)

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu 
                405                 410                 415     


Cys Ser Ile Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Val Ala Ala Ile Arg Trp Ser Gly Gly Ser Thr Tyr Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Lys Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Ala Ser Ala Ala Pro Tyr Ser Ser Trp Ser Arg Gly Leu 
                485                 490                 495     


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His 
            500                 505                 510         


His His His His His Glu Pro Glu Ala 
        515                 520     


<210>  21
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbG9c7HopQ MegaBody (CA15899)

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
                405                 410                 415     


Ser Thr Tyr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Val Ala Gly Trp Asn Ser Ile Asn Ile Tyr Tyr Ala Asp Ser 
        435                 440                 445             


Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Ser Thr Val 
    450                 455                 460                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
465                 470                 475                 480 


Cys Ala Ala Arg Gly Leu Gly Gln Thr Glu Tyr Asn Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Gln Val Thr Val Ser Ser His His His His His His Glu Pro 
            500                 505                 510         


Glu Ala 
        


<210>  22
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbA12c7HopQ MegaBody (CA15900)

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
                405                 410                 415     


Ser Ser Tyr Asn Met Ala Trp Phe Arg Gln Val Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Val Ala Ser Ile Ala Arg Thr Gly Ser Gly Thr Tyr Tyr Arg 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Thr Ala Gly Gly Ser Leu Ala Thr Ile Ser Asp Tyr Trp 
                485                 490                 495     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His His His His 
            500                 505                 510         


Glu Pro Glu Ala 
        515     


<210>  23
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbB7c7HopQ MegaBody (CA15901)

<400>  23

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe 
                405                 410                 415     


Ser Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Ala Ala Gly Ile Thr Gly Thr Ala Gly Ile Thr Tyr Tyr Thr 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Ala Gly Leu Thr Ser Tyr Ala Gly Arg Gly Ala Ala 
                485                 490                 495     


Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His 
            500                 505                 510         


His His His His His Glu Pro Glu Ala 
        515                 520     


<210>  24
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbE8c7HopQ MegaBody (CA15902)

<400>  24

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Glu Arg Thr Phe 
                405                 410                 415     


Ser Ser His His Met Ala Trp Phe Arg Gln Ala Pro Gly Met Glu Arg 
            420                 425                 430         


Glu Phe Val Ala Gly Ile Ser Trp Ser Phe Gly Thr Thr Ser Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Gly 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Ala Met Pro Thr Tyr Arg Gly Arg Lys Tyr Tyr Leu 
                485                 490                 495     


Ala Asp Asp Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            500                 505                 510         


Ser His His His His His His Glu Pro Glu Ala 
        515                 520             


<210>  25
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNb2_B9c7HopQ MegaBody (CA15903)

<400>  25

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Val Arg Ser Ala Arg Thr Phe 
                405                 410                 415     


Gly Ser Val Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Val Thr Ala Ile Asp Trp Ser Gly Ser Asn Thr Leu Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Ala Ser Arg Arg Val Val Val Thr Thr Ser Asp Phe 
                485                 490                 495     


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His 
            500                 505                 510         


His His His Glu Pro Glu Ala 
        515                 


<210>  26
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbE4c7HopQ MegaBody (CA15191)

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
                405                 410                 415     


Gly Ser Thr Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Asp Phe Val Ala Ser Ile Thr Trp Asn Arg Gly Leu Thr Thr Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn 
    450                 455                 460                 


Thr Val Asp Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Val Leu Gly Met Gly Thr Ser Phe Ala Ser Trp Gly Gln 
                485                 490                 495     


Gly Thr Gln Val Thr Val Ser Ser His His His His His His Glu Pro 
            500                 505                 510         


Glu Ala 
        


<210>  27
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbH5c7HopQ MegaBody (CA15904)

<400>  27

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                405                 410                 415     


Ser Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            420                 425                 430         


Glu Trp Val Ser Arg Ile Leu Thr Asp Gly Gly Thr Thr Ser Tyr Pro 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Arg Gly Trp Pro Ser Asp Gly Tyr Ser Gly Gly Tyr 
                485                 490                 495     


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His His His 
            500                 505                 510         


His Glu Pro Glu Ala 
        515         


<210>  28
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbC10c7HopQ MegaBody (CA15905)

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser 
                405                 410                 415     


Gly Ser Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Ala Ala Ala Ile Ser Phe Thr Ala Gly Val Thr Tyr Tyr Ser 
        435                 440                 445             


Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn 
    450                 455                 460                 


Thr Ala Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Thr Leu Pro Ser Leu Val Leu Ile Leu Thr Ala Lys 
                485                 490                 495     


Pro Asn Ile Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 510         


His His His His His His Glu Pro Glu Ala 
        515                 520         


<210>  29
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbA5c7HopQ MegaBody (CA15906)

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
                405                 410                 415     


Ser Asn Ser Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro 
            420                 425                 430         


Glu Trp Val Ser Ser Ile Ser Pro Ser Ala Trp Ile Ile Thr His Gly 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Leu Tyr Leu Gln Met Asn His Leu Lys Pro Glu Asp Ala Ala Leu 
465                 470                 475                 480 


Tyr Tyr Cys Ala Arg Arg Gln Gly Tyr Asp Gly Tyr Val Pro Ser Arg 
                485                 490                 495     


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His 
            500                 505                 510         


His His His Glu Pro Glu Ala 
        515                 


<210>  30
<211>  514
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbB4c7HopQ MegaBody (CA15907)

<400>  30

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Ser Phe Phe 
                405                 410                 415     


Asn Ile Tyr Asp Leu Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
            420                 425                 430         


Glu Leu Val Ala Ser Ile Thr Lys Val Gly Ser Thr Asn Tyr Ala Asp 
        435                 440                 445             


Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Lys Thr 
    450                 455                 460                 


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Asn Leu Val Ser Pro Gly Gly Val Tyr Asn Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Gln Val Thr Val Ser Ser His His His His His His Glu Pro 
            500                 505                 510         


Glu Ala 
        


<210>  31
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbF3c7HopQ MegaBody (CA15192)

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe 
                405                 410                 415     


Gly Pro Asn Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg 
            420                 425                 430         


Glu Leu Val Ala Thr Ile Asn Arg Ile Gly Asn Ile Asn Tyr Gly Asp 
        435                 440                 445             


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Glu Ile Ala Val Asn Thr 
    450                 455                 460                 


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Asn Tyr 
465                 470                 475                 480 


Tyr Cys Tyr Ala Ala Lys Tyr Gly Val Asp Tyr Trp Gly Lys Gly Thr 
                485                 490                 495     


Gln Val Thr Val Ser Ser His His His His His His Glu Pro Glu Ala 
            500                 505                 510         


<210>  32
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbB1c7HopQ MegaBody (CA15908)

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu 
                405                 410                 415     


Ser Ser Ser Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Ile 
            420                 425                 430         


Glu Trp Val Ser Thr Ile Ser Pro Gly Gly Arg Ile Thr Tyr Ala Val 
        435                 440                 445             


Ser Val Glu Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr 
    450                 455                 460                 


Leu Ser Leu Gln Met Asn Glu Leu Lys Pro Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Arg Arg Leu Gly Glu Lys Gly Gln Gly Thr Gln Val Thr Val 
                485                 490                 495     


Ser Ser His His His His His His Glu Pro Glu Ala 
            500                 505             


<210>  33
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbE1c7HopQ MegaBody (CA15909)

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Thr 
                405                 410                 415     


Arg Ser Pro Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Arg Gln Arg 
            420                 425                 430         


Glu Trp Val Thr Ser Ile Leu Gly Thr Gly Arg Thr Asp Tyr Ala Asp 
        435                 440                 445             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr 
    450                 455                 460                 


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Ser Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Tyr Thr Val Leu Asn Gly Arg Pro Ser Trp Gly Gln Gly Thr 
                485                 490                 495     


Gln Val Thr Val Ser Ser His His His His His His Glu Pro Glu Ala 
            500                 505                 510         


<210>  34
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MegaBody MbNb25c7HopQ against GABAAR-beta3

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe 
                405                 410                 415     


Asn Tyr Pro Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Val Gly Ala Ile Ser Trp Ser Gly Gly Ser Thr Ser Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Val Tyr Leu Glu Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Ala Lys Gly Arg Tyr Ser Gly Gly Leu Tyr Tyr Pro 
                485                 490                 495     


Thr Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 510         


His His His His His His Glu Pro Glu Ala 
        515                 520         


<210>  35
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human GABAAR-beta3 with C-terminal 1D4 tag

<400>  35

Gln Ser Val Asn Asp Pro Gly Asn Met Ser Phe Val Lys Glu Thr Val 
1               5                   10                  15      


Asp Lys Leu Leu Lys Gly Tyr Asp Ile Arg Leu Arg Pro Asp Phe Gly 
            20                  25                  30          


Gly Pro Pro Val Cys Val Gly Met Asn Ile Asp Ile Ala Ser Ile Asp 
        35                  40                  45              


Met Val Ser Glu Val Asn Met Asp Tyr Thr Leu Thr Met Tyr Phe Gln 
    50                  55                  60                  


Gln Tyr Trp Arg Asp Lys Arg Leu Ala Tyr Ser Gly Ile Pro Leu Asn 
65                  70                  75                  80  


Leu Thr Leu Asp Asn Arg Val Ala Asp Gln Leu Trp Val Pro Asp Thr 
                85                  90                  95      


Tyr Phe Leu Asn Asp Lys Lys Ser Phe Val His Gly Val Thr Val Lys 
            100                 105                 110         


Asn Arg Met Ile Arg Leu His Pro Asp Gly Thr Val Leu Tyr Gly Leu 
        115                 120                 125             


Arg Ile Thr Thr Thr Ala Ala Cys Met Met Asp Leu Arg Arg Tyr Pro 
    130                 135                 140                 


Leu Asp Glu Gln Asn Cys Thr Leu Glu Ile Glu Ser Tyr Gly Tyr Thr 
145                 150                 155                 160 


Thr Asp Asp Ile Glu Phe Tyr Trp Arg Gly Gly Asp Lys Ala Val Thr 
                165                 170                 175     


Gly Val Glu Arg Ile Glu Leu Pro Gln Phe Ser Ile Val Glu His Arg 
            180                 185                 190         


Leu Val Ser Arg Asn Val Val Phe Ala Thr Gly Ala Tyr Pro Arg Leu 
        195                 200                 205             


Ser Leu Ser Phe Arg Leu Lys Arg Asn Ile Gly Tyr Phe Ile Leu Gln 
    210                 215                 220                 


Thr Tyr Met Pro Ser Ile Leu Ile Thr Ile Leu Ser Trp Val Ser Phe 
225                 230                 235                 240 


Trp Ile Asn Tyr Asp Ala Ser Ala Ala Arg Val Ala Leu Gly Ile Thr 
                245                 250                 255     


Thr Val Leu Thr Met Thr Thr Ile Asn Thr His Leu Arg Glu Thr Leu 
            260                 265                 270         


Pro Lys Ile Pro Tyr Val Thr Ala Ile Asp Met Tyr Leu Met Gly Cys 
        275                 280                 285             


Phe Val Phe Val Phe Leu Ala Leu Leu Glu Tyr Ala Phe Val Asn Tyr 
    290                 295                 300                 


Ile Phe Phe Ser Gln Pro Ala Arg Ala Ala Ala Ile Asp Arg Trp Ser 
305                 310                 315                 320 


Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn Leu Val Tyr Trp 
                325                 330                 335     


Leu Tyr Tyr Val Asn Gly Ala Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345                 350         


<210>  36
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nanobody Nb25 against GABAAR-beta3 (CA8125)

<400>  36

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly His Thr Phe Asn Tyr Pro 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Ala Ile Ser Trp Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Gly Arg Tyr Ser Gly Gly Leu Tyr Tyr Pro Thr Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His 
        115                 120                 125             


His His His Glu Pro Glu Ala 
    130                 135 


<210>  37
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_B9 Nanobody (CA15883)

<400>  37

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Cys Ser Ile 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Ala Pro Tyr Ser Ser Trp Ser Arg Gly Leu Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  38
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_G9 Nanobody (CA15884)

<400>  38

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Trp Asn Ser Ile Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Ser Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                85                  90                  95      


Arg Gly Leu Gly Gln Thr Glu Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  39
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_A12 Nanobody (CA15885)

<400>  39

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Ala Trp Phe Arg Gln Val Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ala Arg Thr Gly Ser Gly Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ala Gly Gly Ser Leu Ala Thr Ile Ser Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  40
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_B7 Nanobody (CA15886)

<400>  40

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Ala Gly Ile Thr Gly Thr Ala Gly Ile Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Leu Thr Ser Tyr Ala Gly Arg Gly Ala Ala Gly Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  41
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_E8 Nanobody (CA15887)

<400>  41

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Pro Glu Arg Thr Phe Ser Ser His 
            20                  25                  30          


His Met Ala Trp Phe Arg Gln Ala Pro Gly Met Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Phe Gly Thr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Gly Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Met Pro Thr Tyr Arg Gly Arg Lys Tyr Tyr Leu Ala Asp Asp 
            100                 105                 110         


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  42
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_B9 Nanobody (CA15888)

<400>  42

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Arg Ser Ala Arg Thr Phe Gly Ser Val 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Thr Ala Ile Asp Trp Ser Gly Ser Asn Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Arg Arg Val Val Val Thr Thr Ser Asp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  43
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_E4 Nanobody (CA15889)

<400>  43

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Gly Ser Thr 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Asp Phe Val 
        35                  40                  45              


Ala Ser Ile Thr Trp Asn Arg Gly Leu Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Leu Gly Met Gly Thr Ser Phe Ala Ser Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  44
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_H5 Nanobody (CA15890)

<400>  44

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Leu Thr Asp Gly Gly Thr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Pro Ser Asp Gly Tyr Ser Gly Gly Tyr Arg Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  45
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_C10 Nanobody (CA15891)

<400>  45

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Arg Thr Ser Gly Ser Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Ala Ala Ile Ser Phe Thr Ala Gly Val Thr Tyr Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Pro Ser Leu Val Leu Ile Leu Thr Ala Lys Pro Asn Ile 
            100                 105                 110         


Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  46
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1522_A5 Nanobody (CA15892)

<400>  46

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asn Ser 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Ala Trp Ile Ile Thr His Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn His Leu Lys Pro Glu Asp Ala Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gln Gly Tyr Asp Gly Tyr Val Pro Ser Arg Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  47
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_B4 Nanobody (CA15893)

<400>  47

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Ser Phe Phe Asn Ile Tyr 
            20                  25                  30          


Asp Leu Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Lys Val Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Val Ser Pro Gly Gly Val Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  48
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_F3 Nanobody (CA15894)

<400>  48

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe Gly Pro Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Arg Ile Gly Asn Ile Asn Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Leu Ser Arg Glu Ile Ala Val Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Asn Tyr Tyr Cys Tyr 
                85                  90                  95      


Ala Ala Lys Tyr Gly Val Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  49
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_B1 Nanobody (CA15895)

<400>  49

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Ser 
            20                  25                  30          


Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Ile Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Pro Gly Gly Arg Ile Thr Tyr Ala Val Ser Val Glu 
    50                  55                  60                  


Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr Leu Ser Leu 
65                  70                  75                  80  


Gln Met Asn Glu Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Arg 
                85                  90                  95      


Arg Leu Gly Glu Lys Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     


<210>  50
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP1521_E1 Nanobody (CA15896)

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Thr Arg Ser Pro 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Arg Gln Arg Glu Trp Val 
        35                  40                  45              


Thr Ser Ile Leu Gly Thr Gly Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Ser Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Thr Val Leu Asn Gly Arg Pro Ser Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  51
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circular permutated E.coli Ygjk protein (PDB 3WFS; cYgjk)

<400>  51

Lys Glu Glu Thr Gln Ser Gly Leu Asn Asn Tyr Ala Arg Val Val Glu 
1               5                   10                  15      


Lys Gly Gln Tyr Asp Ser Leu Glu Ile Pro Ala Gln Val Ala Ala Ser 
            20                  25                  30          


Trp Glu Ser Gly Arg Asp Asp Ala Ala Val Phe Gly Phe Ile Asp Lys 
        35                  40                  45              


Glu Gln Leu Asp Lys Tyr Val Ala Asn Gly Gly Lys Arg Ser Asp Trp 
    50                  55                  60                  


Thr Val Lys Phe Ala Glu Asn Arg Ser Gln Asp Gly Thr Leu Leu Gly 
65                  70                  75                  80  


Tyr Ser Leu Leu Gln Glu Ser Val Asp Gln Ala Ser Tyr Met Tyr Ser 
                85                  90                  95      


Asp Asn His Tyr Leu Ala Glu Met Ala Thr Ile Leu Gly Lys Pro Glu 
            100                 105                 110         


Glu Ala Lys Arg Tyr Arg Gln Leu Ala Gln Gln Leu Ala Asp Tyr Ile 
        115                 120                 125             


Asn Thr Cys Met Phe Asp Pro Thr Thr Gln Phe Tyr Tyr Asp Val Arg 
    130                 135                 140                 


Ile Glu Asp Lys Pro Leu Ala Asn Gly Cys Ala Gly Lys Pro Ile Val 
145                 150                 155                 160 


Glu Arg Gly Lys Gly Pro Glu Gly Trp Ser Pro Leu Phe Asn Gly Ala 
                165                 170                 175     


Ala Thr Gln Ala Asn Ala Asp Ala Val Val Lys Val Met Leu Asp Pro 
            180                 185                 190         


Lys Glu Phe Asn Thr Phe Val Pro Leu Gly Thr Ala Ala Leu Thr Asn 
        195                 200                 205             


Pro Ala Phe Gly Ala Asp Ile Tyr Trp Arg Gly Arg Val Trp Val Asp 
    210                 215                 220                 


Gln Phe Trp Phe Gly Leu Lys Gly Met Glu Arg Tyr Gly Tyr Arg Asp 
225                 230                 235                 240 


Asp Ala Leu Lys Leu Ala Asp Thr Phe Phe Arg His Ala Lys Gly Leu 
                245                 250                 255     


Thr Ala Asp Gly Pro Ile Gln Glu Asn Tyr Asn Pro Leu Thr Gly Ala 
            260                 265                 270         


Gln Gln Gly Ala Pro Asn Phe Ser Trp Ser Ala Ala His Leu Tyr Met 
        275                 280                 285             


Leu Tyr Asn Asp Phe Phe Arg Lys Gln Ala Ser Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ala Asp Asn Tyr Lys 
305                 310                 315                 320 


Asn Val Ile Asn Arg Thr Gly Ala Pro Gln Tyr Met Lys Asp Tyr Asp 
                325                 330                 335     


Tyr Asp Asp His Gln Arg Phe Asn Pro Phe Phe Asp Leu Gly Ala Trp 
            340                 345                 350         


His Gly His Leu Leu Pro Asp Gly Pro Asn Thr Met Gly Gly Phe Pro 
        355                 360                 365             


Gly Val Ala Leu Leu Thr Glu Glu Tyr Ile Asn Phe Met Ala Ser Asn 
    370                 375                 380                 


Phe Asp Arg Leu Thr Val Trp Gln Asp Gly Lys Lys Val Asp Phe Thr 
385                 390                 395                 400 


Leu Glu Ala Tyr Ser Ile Pro Gly Ala Leu Val Gln Lys Leu Thr Ala 
                405                 410                 415     


Lys Asp Val Gln Val Glu Met Thr Leu Arg Phe Ala Thr Pro Arg Thr 
            420                 425                 430         


Ser Leu Leu Glu Thr Lys Ile Thr Ser Asn Lys Pro Leu Asp Leu Val 
        435                 440                 445             


Trp Asp Gly Glu Leu Leu Glu Lys Leu Glu Ala Lys Glu Gly Lys Pro 
    450                 455                 460                 


Leu Ser Asp Lys Thr Ile Ala Gly Glu Tyr Pro Asp Tyr Gln Arg Lys 
465                 470                 475                 480 


Ile Ser Ala Thr Arg Asp Gly Leu Lys Val Thr Phe Gly Lys Val Arg 
                485                 490                 495     


Ala Thr Trp Asp Leu Leu Thr Ser Gly Glu Ser Glu Tyr Gln Val His 
            500                 505                 510         


Lys Ser Leu Pro Val Gln Thr Glu Ile Asn Gly Asn Arg Phe Thr Ser 
        515                 520                 525             


Lys Ala His Ile Asn Gly Ser Thr Thr Leu Tyr Thr Thr Tyr Ser His 
    530                 535                 540                 


Leu Leu Thr Ala Gln Glu Val Ser Lys Glu Gln Met Gln Ile Arg Asp 
545                 550                 555                 560 


Ile Leu Ala Arg Pro Ala Phe Tyr Leu Thr Ala Ser Gln Gln Arg Trp 
                565                 570                 575     


Glu Glu Tyr Leu Lys Lys Gly Leu Thr Asn Pro Asp Ala Thr Pro Glu 
            580                 585                 590         


Gln Thr Arg Val Ala Val Lys Ala Ile Glu Thr Leu Asn Gly Asn Trp 
        595                 600                 605             


Arg Ser Pro Gly Gly Ala Val Lys Phe Asn Thr Val Thr Pro Ser Val 
    610                 615                 620                 


Thr Gly Arg Trp Phe Ser Gly Asn Gln Thr Trp Pro Trp Asp Thr Trp 
625                 630                 635                 640 


Lys Gln Ala Phe Ala Met Ala His Phe Asn Pro Asp Ile Ala Lys Glu 
                645                 650                 655     


Asn Ile Arg Ala Val Phe Ser Trp Gln Ile Gln Pro Gly Asp Ser Val 
            660                 665                 670         


Arg Pro Gln Asp Val Gly Phe Val Pro Asp Leu Ile Ala Trp Asn Leu 
        675                 680                 685             


Ser Pro Glu Arg Gly Gly Asp Gly Gly Asn Trp Asn Glu Arg Asn Thr 
    690                 695                 700                 


Lys Pro Ser Leu Ala Ala Trp Ser Val Met Glu Val Tyr Asn Val Thr 
705                 710                 715                 720 


Gln Asp Lys Thr Trp Val Ala Glu Met Tyr Pro Lys Leu Val Ala Tyr 
                725                 730                 735     


His Asp Trp Trp Leu Arg Asn Arg Asp His Asn Gly Asn Gly Val Pro 
            740                 745                 750         


Glu Tyr Gly Ala Thr Arg Asp Lys Ala His Asn Thr Glu Ser Gly Glu 
        755                 760                 765             


Met Leu Phe Thr Val Lys Lys 
    770                 775 


<210>  52
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbF3cYgjk_NO MegaBody

<400>  52

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Glu Glu Thr 
1               5                   10                  15      


Gln Ser Gly Leu Asn Asn Tyr Ala Arg Val Val Glu Lys Gly Gln Tyr 
            20                  25                  30          


Asp Ser Leu Glu Ile Pro Ala Gln Val Ala Ala Ser Trp Glu Ser Gly 
        35                  40                  45              


Arg Asp Asp Ala Ala Val Phe Gly Phe Ile Asp Lys Glu Gln Leu Asp 
    50                  55                  60                  


Lys Tyr Val Ala Asn Gly Gly Lys Arg Ser Asp Trp Thr Val Lys Phe 
65                  70                  75                  80  


Ala Glu Asn Arg Ser Gln Asp Gly Thr Leu Leu Gly Tyr Ser Leu Leu 
                85                  90                  95      


Gln Glu Ser Val Asp Gln Ala Ser Tyr Met Tyr Ser Asp Asn His Tyr 
            100                 105                 110         


Leu Ala Glu Met Ala Thr Ile Leu Gly Lys Pro Glu Glu Ala Lys Arg 
        115                 120                 125             


Tyr Arg Gln Leu Ala Gln Gln Leu Ala Asp Tyr Ile Asn Thr Cys Met 
    130                 135                 140                 


Phe Asp Pro Thr Thr Gln Phe Tyr Tyr Asp Val Arg Ile Glu Asp Lys 
145                 150                 155                 160 


Pro Leu Ala Asn Gly Cys Ala Gly Lys Pro Ile Val Glu Arg Gly Lys 
                165                 170                 175     


Gly Pro Glu Gly Trp Ser Pro Leu Phe Asn Gly Ala Ala Thr Gln Ala 
            180                 185                 190         


Asn Ala Asp Ala Val Val Lys Val Met Leu Asp Pro Lys Glu Phe Asn 
        195                 200                 205             


Thr Phe Val Pro Leu Gly Thr Ala Ala Leu Thr Asn Pro Ala Phe Gly 
    210                 215                 220                 


Ala Asp Ile Tyr Trp Arg Gly Arg Val Trp Val Asp Gln Phe Trp Phe 
225                 230                 235                 240 


Gly Leu Lys Gly Met Glu Arg Tyr Gly Tyr Arg Asp Asp Ala Leu Lys 
                245                 250                 255     


Leu Ala Asp Thr Phe Phe Arg His Ala Lys Gly Leu Thr Ala Asp Gly 
            260                 265                 270         


Pro Ile Gln Glu Asn Tyr Asn Pro Leu Thr Gly Ala Gln Gln Gly Ala 
        275                 280                 285             


Pro Asn Phe Ser Trp Ser Ala Ala His Leu Tyr Met Leu Tyr Asn Asp 
    290                 295                 300                 


Phe Phe Arg Lys Gln Ala Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Gly Asn Ala Asp Asn Tyr Lys Asn Val Ile Asn 
                325                 330                 335     


Arg Thr Gly Ala Pro Gln Tyr Met Lys Asp Tyr Asp Tyr Asp Asp His 
            340                 345                 350         


Gln Arg Phe Asn Pro Phe Phe Asp Leu Gly Ala Trp His Gly His Leu 
        355                 360                 365             


Leu Pro Asp Gly Pro Asn Thr Met Gly Gly Phe Pro Gly Val Ala Leu 
    370                 375                 380                 


Leu Thr Glu Glu Tyr Ile Asn Phe Met Ala Ser Asn Phe Asp Arg Leu 
385                 390                 395                 400 


Thr Val Trp Gln Asp Gly Lys Lys Val Asp Phe Thr Leu Glu Ala Tyr 
                405                 410                 415     


Ser Ile Pro Gly Ala Leu Val Gln Lys Leu Thr Ala Lys Asp Val Gln 
            420                 425                 430         


Val Glu Met Thr Leu Arg Phe Ala Thr Pro Arg Thr Ser Leu Leu Glu 
        435                 440                 445             


Thr Lys Ile Thr Ser Asn Lys Pro Leu Asp Leu Val Trp Asp Gly Glu 
    450                 455                 460                 


Leu Leu Glu Lys Leu Glu Ala Lys Glu Gly Lys Pro Leu Ser Asp Lys 
465                 470                 475                 480 


Thr Ile Ala Gly Glu Tyr Pro Asp Tyr Gln Arg Lys Ile Ser Ala Thr 
                485                 490                 495     


Arg Asp Gly Leu Lys Val Thr Phe Gly Lys Val Arg Ala Thr Trp Asp 
            500                 505                 510         


Leu Leu Thr Ser Gly Glu Ser Glu Tyr Gln Val His Lys Ser Leu Pro 
        515                 520                 525             


Val Gln Thr Glu Ile Asn Gly Asn Arg Phe Thr Ser Lys Ala His Ile 
    530                 535                 540                 


Asn Gly Ser Thr Thr Leu Tyr Thr Thr Tyr Ser His Leu Leu Thr Ala 
545                 550                 555                 560 


Gln Glu Val Ser Lys Glu Gln Met Gln Ile Arg Asp Ile Leu Ala Arg 
                565                 570                 575     


Pro Ala Phe Tyr Leu Thr Ala Ser Gln Gln Arg Trp Glu Glu Tyr Leu 
            580                 585                 590         


Lys Lys Gly Leu Thr Asn Pro Asp Ala Thr Pro Glu Gln Thr Arg Val 
        595                 600                 605             


Ala Val Lys Ala Ile Glu Thr Leu Asn Gly Asn Trp Arg Ser Pro Gly 
    610                 615                 620                 


Gly Ala Val Lys Phe Asn Thr Val Thr Pro Ser Val Thr Gly Arg Trp 
625                 630                 635                 640 


Phe Ser Gly Asn Gln Thr Trp Pro Trp Asp Thr Trp Lys Gln Ala Phe 
                645                 650                 655     


Ala Met Ala His Phe Asn Pro Asp Ile Ala Lys Glu Asn Ile Arg Ala 
            660                 665                 670         


Val Phe Ser Trp Gln Ile Gln Pro Gly Asp Ser Val Arg Pro Gln Asp 
        675                 680                 685             


Val Gly Phe Val Pro Asp Leu Ile Ala Trp Asn Leu Ser Pro Glu Arg 
    690                 695                 700                 


Gly Gly Asp Gly Gly Asn Trp Asn Glu Arg Asn Thr Lys Pro Ser Leu 
705                 710                 715                 720 


Ala Ala Trp Ser Val Met Glu Val Tyr Asn Val Thr Gln Asp Lys Thr 
                725                 730                 735     


Trp Val Ala Glu Met Tyr Pro Lys Leu Val Ala Tyr His Asp Trp Trp 
            740                 745                 750         


Leu Arg Asn Arg Asp His Asn Gly Asn Gly Val Pro Glu Tyr Gly Ala 
        755                 760                 765             


Thr Arg Asp Lys Ala His Asn Thr Glu Ser Gly Glu Met Leu Phe Thr 
    770                 775                 780                 


Val Lys Lys Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe 
785                 790                 795                 800 


Gly Pro Asn Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg 
                805                 810                 815     


Glu Leu Val Ala Thr Ile Asn Arg Ile Gly Asn Ile Asn Tyr Gly Asp 
            820                 825                 830         


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Glu Ile Ala Val Asn Thr 
        835                 840                 845             


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Asn Tyr 
    850                 855                 860                 


Tyr Cys Tyr Ala Ala Lys Tyr Gly Val Asp Tyr Trp Gly Lys Gly Thr 
865                 870                 875                 880 


Gln Val Thr Val Ser Ser His His His His His His Glu Pro Glu Ala 
                885                 890                 895     


<210>  53
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNb1_B9c7HopQ MegaBody (CA15898)

<400>  53

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu 
                405                 410                 415     


Cys Ser Ile Pro Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Val Ala Ala Ile Arg Trp Ser Gly Gly Ser Thr Tyr Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Lys Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Ala Ser Ala Ala Pro Tyr Ser Ser Trp Ser Arg Gly Leu 
                485                 490                 495     


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 510     


<210>  54
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbG9c7HopQ MegaBody (CA15899)

<400>  54

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
                405                 410                 415     


Ser Thr Tyr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Val Ala Gly Trp Asn Ser Ile Asn Ile Tyr Tyr Ala Asp Ser 
        435                 440                 445             


Val Lys Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Ser Thr Val 
    450                 455                 460                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
465                 470                 475                 480 


Cys Ala Ala Arg Gly Leu Gly Gln Thr Glu Tyr Asn Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Gln Val Thr Val Ser Ser 
            500                 


<210>  55
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbA12c7HopQ MegaBody (CA15900)

<400>  55

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
                405                 410                 415     


Ser Ser Tyr Asn Met Ala Trp Phe Arg Gln Val Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Val Ala Ser Ile Ala Arg Thr Gly Ser Gly Thr Tyr Tyr Arg 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Gln Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Thr Ala Gly Gly Ser Leu Ala Thr Ile Ser Asp Tyr Trp 
                485                 490                 495     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505     


<210>  56
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbB7c7HopQ MegaBody (CA15901)

<400>  56

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ser Phe 
                405                 410                 415     


Ser Ser Tyr Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Ala Ala Gly Ile Thr Gly Thr Ala Gly Ile Thr Tyr Tyr Thr 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Ala Gly Leu Thr Ser Tyr Ala Gly Arg Gly Ala Ala 
                485                 490                 495     


Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 510     


<210>  57
<211>  513
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbE8c7HopQ MegaBody (CA15902)

<400>  57

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Pro Glu Arg Thr Phe 
                405                 410                 415     


Ser Ser His His Met Ala Trp Phe Arg Gln Ala Pro Gly Met Glu Arg 
            420                 425                 430         


Glu Phe Val Ala Gly Ile Ser Trp Ser Phe Gly Thr Thr Ser Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Gly 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Ala Met Pro Thr Tyr Arg Gly Arg Lys Tyr Tyr Leu 
                485                 490                 495     


Ala Asp Asp Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            500                 505                 510         


Ser 
    


<210>  58
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNb2_B9c7HopQ MegaBody (CA15903)

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Val Arg Ser Ala Arg Thr Phe 
                405                 410                 415     


Gly Ser Val Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Val Thr Ala Ile Asp Trp Ser Gly Ser Asn Thr Leu Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Ala Ser Arg Arg Val Val Val Thr Thr Ser Asp Phe 
                485                 490                 495     


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 


<210>  59
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbE4c7HopQ MegaBody (CA15191)

<400>  59

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe 
                405                 410                 415     


Gly Ser Thr Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Asp Phe Val Ala Ser Ile Thr Trp Asn Arg Gly Leu Thr Thr Tyr Ala 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn 
    450                 455                 460                 


Thr Val Asp Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Val Leu Gly Met Gly Thr Ser Phe Ala Ser Trp Gly Gln 
                485                 490                 495     


Gly Thr Gln Val Thr Val Ser Ser 
            500                 


<210>  60
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbH5c7HopQ MegaBody (CA15904)

<400>  60

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
                405                 410                 415     


Ser Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            420                 425                 430         


Glu Trp Val Ser Arg Ile Leu Thr Asp Gly Gly Thr Thr Ser Tyr Pro 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Leu Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Arg Gly Trp Pro Ser Asp Gly Tyr Ser Gly Gly Tyr 
                485                 490                 495     


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505         


<210>  61
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbC10c7HopQ MegaBody (CA15905)

<400>  61

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser 
                405                 410                 415     


Gly Ser Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            420                 425                 430         


Glu Phe Ala Ala Ala Ile Ser Phe Thr Ala Gly Val Thr Tyr Tyr Ser 
        435                 440                 445             


Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn 
    450                 455                 460                 


Thr Ala Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val 
465                 470                 475                 480 


Tyr Tyr Cys Ala Thr Leu Pro Ser Leu Val Leu Ile Leu Thr Ala Lys 
                485                 490                 495     


Pro Asn Ile Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 510         


<210>  62
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbA5c7HopQ MegaBody (CA15906)

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
                405                 410                 415     


Ser Asn Ser Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro 
            420                 425                 430         


Glu Trp Val Ser Ser Ile Ser Pro Ser Ala Trp Ile Ile Thr His Gly 
        435                 440                 445             


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    450                 455                 460                 


Thr Leu Tyr Leu Gln Met Asn His Leu Lys Pro Glu Asp Ala Ala Leu 
465                 470                 475                 480 


Tyr Tyr Cys Ala Arg Arg Gln Gly Tyr Asp Gly Tyr Val Pro Ser Arg 
                485                 490                 495     


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505                 


<210>  63
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbB4c7HopQ MegaBody (CA15907)

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Lys Ser Phe Phe 
                405                 410                 415     


Asn Ile Tyr Asp Leu Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
            420                 425                 430         


Glu Leu Val Ala Ser Ile Thr Lys Val Gly Ser Thr Asn Tyr Ala Asp 
        435                 440                 445             


Ser Val Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Lys Thr 
    450                 455                 460                 


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Asn Leu Val Ser Pro Gly Gly Val Tyr Asn Tyr Trp Gly Gln 
                485                 490                 495     


Gly Thr Gln Val Thr Val Ser Ser 
            500                 


<210>  64
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbF3c7HopQ MegaBody (CA15192)

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe 
                405                 410                 415     


Gly Pro Asn Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg 
            420                 425                 430         


Glu Leu Val Ala Thr Ile Asn Arg Ile Gly Asn Ile Asn Tyr Gly Asp 
        435                 440                 445             


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Glu Ile Ala Val Asn Thr 
    450                 455                 460                 


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Asn Tyr 
465                 470                 475                 480 


Tyr Cys Tyr Ala Ala Lys Tyr Gly Val Asp Tyr Trp Gly Lys Gly Thr 
                485                 490                 495     


Gln Val Thr Val Ser Ser 
            500         


<210>  65
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbB1c7HopQ MegaBody (CA15908)

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu 
                405                 410                 415     


Ser Ser Ser Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Ile 
            420                 425                 430         


Glu Trp Val Ser Thr Ile Ser Pro Gly Gly Arg Ile Thr Tyr Ala Val 
        435                 440                 445             


Ser Val Glu Gly Arg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr 
    450                 455                 460                 


Leu Ser Leu Gln Met Asn Glu Leu Lys Pro Glu Asp Thr Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Arg Arg Leu Gly Glu Lys Gly Gln Gly Thr Gln Val Thr Val 
                485                 490                 495     


Ser Ser 
        


<210>  66
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbE1c7HopQ MegaBody (CA15909)

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Lys Thr 
1               5                   10                  15      


Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn Leu Leu Thr 
            20                  25                  30          


Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys Pro Ile Leu 
        35                  40                  45              


Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn Ala Asn Thr 
    50                  55                  60                  


Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys Ala Thr Phe 
65                  70                  75                  80  


Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn Ala Gln Lys 
                85                  90                  95      


Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro Lys Asn Ile 
            100                 105                 110         


Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser Leu Thr Ala 
        115                 120                 125             


Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala Glu Ile Leu 
    130                 135                 140                 


Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu Ser Ser Gly 
145                 150                 155                 160 


His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala Ile Ser Ser 
                165                 170                 175     


Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly Asn Gly Cys 
            180                 185                 190         


Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser Ala Ala Asp 
        195                 200                 205             


Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn Leu Ala Asn 
    210                 215                 220                 


Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln Leu Ser Arg 
225                 230                 235                 240 


Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser Ala Gln Ala 
                245                 250                 255     


Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys Thr Leu Ala 
            260                 265                 270         


Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu Leu Ala Leu 
        275                 280                 285             


Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala Val Ile Cys 
    290                 295                 300                 


Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys Asp Phe His 
305                 310                 315                 320 


Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys Gly Gly Ser 
                325                 330                 335     


Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn Thr Leu Lys 
            340                 345                 350         


Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu Lys Ile His 
        355                 360                 365             


Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala Gly Leu Ala 
    370                 375                 380                 


Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val Thr Thr Ser 
385                 390                 395                 400 


Lys Tyr Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Thr 
                405                 410                 415     


Arg Ser Pro Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Arg Gln Arg 
            420                 425                 430         


Glu Trp Val Thr Ser Ile Leu Gly Thr Gly Arg Thr Asp Tyr Ala Asp 
        435                 440                 445             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr 
    450                 455                 460                 


Val Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp Ser Ala Val Tyr 
465                 470                 475                 480 


Tyr Cys Tyr Thr Val Leu Asn Gly Arg Pro Ser Trp Gly Gln Gly Thr 
                485                 490                 495     


Gln Val Thr Val Ser Ser 
            500         


<210>  67
<211>  886
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MbNbF3cYgjk_NO MegaBody

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Glu Glu Thr 
1               5                   10                  15      


Gln Ser Gly Leu Asn Asn Tyr Ala Arg Val Val Glu Lys Gly Gln Tyr 
            20                  25                  30          


Asp Ser Leu Glu Ile Pro Ala Gln Val Ala Ala Ser Trp Glu Ser Gly 
        35                  40                  45              


Arg Asp Asp Ala Ala Val Phe Gly Phe Ile Asp Lys Glu Gln Leu Asp 
    50                  55                  60                  


Lys Tyr Val Ala Asn Gly Gly Lys Arg Ser Asp Trp Thr Val Lys Phe 
65                  70                  75                  80  


Ala Glu Asn Arg Ser Gln Asp Gly Thr Leu Leu Gly Tyr Ser Leu Leu 
                85                  90                  95      


Gln Glu Ser Val Asp Gln Ala Ser Tyr Met Tyr Ser Asp Asn His Tyr 
            100                 105                 110         


Leu Ala Glu Met Ala Thr Ile Leu Gly Lys Pro Glu Glu Ala Lys Arg 
        115                 120                 125             


Tyr Arg Gln Leu Ala Gln Gln Leu Ala Asp Tyr Ile Asn Thr Cys Met 
    130                 135                 140                 


Phe Asp Pro Thr Thr Gln Phe Tyr Tyr Asp Val Arg Ile Glu Asp Lys 
145                 150                 155                 160 


Pro Leu Ala Asn Gly Cys Ala Gly Lys Pro Ile Val Glu Arg Gly Lys 
                165                 170                 175     


Gly Pro Glu Gly Trp Ser Pro Leu Phe Asn Gly Ala Ala Thr Gln Ala 
            180                 185                 190         


Asn Ala Asp Ala Val Val Lys Val Met Leu Asp Pro Lys Glu Phe Asn 
        195                 200                 205             


Thr Phe Val Pro Leu Gly Thr Ala Ala Leu Thr Asn Pro Ala Phe Gly 
    210                 215                 220                 


Ala Asp Ile Tyr Trp Arg Gly Arg Val Trp Val Asp Gln Phe Trp Phe 
225                 230                 235                 240 


Gly Leu Lys Gly Met Glu Arg Tyr Gly Tyr Arg Asp Asp Ala Leu Lys 
                245                 250                 255     


Leu Ala Asp Thr Phe Phe Arg His Ala Lys Gly Leu Thr Ala Asp Gly 
            260                 265                 270         


Pro Ile Gln Glu Asn Tyr Asn Pro Leu Thr Gly Ala Gln Gln Gly Ala 
        275                 280                 285             


Pro Asn Phe Ser Trp Ser Ala Ala His Leu Tyr Met Leu Tyr Asn Asp 
    290                 295                 300                 


Phe Phe Arg Lys Gln Ala Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Gly Asn Ala Asp Asn Tyr Lys Asn Val Ile Asn 
                325                 330                 335     


Arg Thr Gly Ala Pro Gln Tyr Met Lys Asp Tyr Asp Tyr Asp Asp His 
            340                 345                 350         


Gln Arg Phe Asn Pro Phe Phe Asp Leu Gly Ala Trp His Gly His Leu 
        355                 360                 365             


Leu Pro Asp Gly Pro Asn Thr Met Gly Gly Phe Pro Gly Val Ala Leu 
    370                 375                 380                 


Leu Thr Glu Glu Tyr Ile Asn Phe Met Ala Ser Asn Phe Asp Arg Leu 
385                 390                 395                 400 


Thr Val Trp Gln Asp Gly Lys Lys Val Asp Phe Thr Leu Glu Ala Tyr 
                405                 410                 415     


Ser Ile Pro Gly Ala Leu Val Gln Lys Leu Thr Ala Lys Asp Val Gln 
            420                 425                 430         


Val Glu Met Thr Leu Arg Phe Ala Thr Pro Arg Thr Ser Leu Leu Glu 
        435                 440                 445             


Thr Lys Ile Thr Ser Asn Lys Pro Leu Asp Leu Val Trp Asp Gly Glu 
    450                 455                 460                 


Leu Leu Glu Lys Leu Glu Ala Lys Glu Gly Lys Pro Leu Ser Asp Lys 
465                 470                 475                 480 


Thr Ile Ala Gly Glu Tyr Pro Asp Tyr Gln Arg Lys Ile Ser Ala Thr 
                485                 490                 495     


Arg Asp Gly Leu Lys Val Thr Phe Gly Lys Val Arg Ala Thr Trp Asp 
            500                 505                 510         


Leu Leu Thr Ser Gly Glu Ser Glu Tyr Gln Val His Lys Ser Leu Pro 
        515                 520                 525             


Val Gln Thr Glu Ile Asn Gly Asn Arg Phe Thr Ser Lys Ala His Ile 
    530                 535                 540                 


Asn Gly Ser Thr Thr Leu Tyr Thr Thr Tyr Ser His Leu Leu Thr Ala 
545                 550                 555                 560 


Gln Glu Val Ser Lys Glu Gln Met Gln Ile Arg Asp Ile Leu Ala Arg 
                565                 570                 575     


Pro Ala Phe Tyr Leu Thr Ala Ser Gln Gln Arg Trp Glu Glu Tyr Leu 
            580                 585                 590         


Lys Lys Gly Leu Thr Asn Pro Asp Ala Thr Pro Glu Gln Thr Arg Val 
        595                 600                 605             


Ala Val Lys Ala Ile Glu Thr Leu Asn Gly Asn Trp Arg Ser Pro Gly 
    610                 615                 620                 


Gly Ala Val Lys Phe Asn Thr Val Thr Pro Ser Val Thr Gly Arg Trp 
625                 630                 635                 640 


Phe Ser Gly Asn Gln Thr Trp Pro Trp Asp Thr Trp Lys Gln Ala Phe 
                645                 650                 655     


Ala Met Ala His Phe Asn Pro Asp Ile Ala Lys Glu Asn Ile Arg Ala 
            660                 665                 670         


Val Phe Ser Trp Gln Ile Gln Pro Gly Asp Ser Val Arg Pro Gln Asp 
        675                 680                 685             


Val Gly Phe Val Pro Asp Leu Ile Ala Trp Asn Leu Ser Pro Glu Arg 
    690                 695                 700                 


Gly Gly Asp Gly Gly Asn Trp Asn Glu Arg Asn Thr Lys Pro Ser Leu 
705                 710                 715                 720 


Ala Ala Trp Ser Val Met Glu Val Tyr Asn Val Thr Gln Asp Lys Thr 
                725                 730                 735     


Trp Val Ala Glu Met Tyr Pro Lys Leu Val Ala Tyr His Asp Trp Trp 
            740                 745                 750         


Leu Arg Asn Arg Asp His Asn Gly Asn Gly Val Pro Glu Tyr Gly Ala 
        755                 760                 765             


Thr Arg Asp Lys Ala His Asn Thr Glu Ser Gly Glu Met Leu Phe Thr 
    770                 775                 780                 


Val Lys Lys Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe 
785                 790                 795                 800 


Gly Pro Asn Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg 
                805                 810                 815     


Glu Leu Val Ala Thr Ile Asn Arg Ile Gly Asn Ile Asn Tyr Gly Asp 
            820                 825                 830         


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Glu Ile Ala Val Asn Thr 
        835                 840                 845             


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ala Ala Asn Tyr 
    850                 855                 860                 


Tyr Cys Tyr Ala Ala Lys Tyr Gly Val Asp Tyr Trp Gly Lys Gly Thr 
865                 870                 875                 880 


Gln Val Thr Val Ser Ser 
                885     


<210>  68
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSP1E1D3

<400>  68

Met Gly His His His His His His His Asp Tyr Asp Ile Pro Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Ser Thr Phe Ser Lys Leu Arg Glu Gln 
            20                  25                  30          


Leu Gly Pro Val Thr Gln Glu Phe Trp Asp Asn Leu Glu Lys Glu Thr 
        35                  40                  45              


Glu Gly Leu Arg Gln Glu Met Ser Lys Asp Leu Glu Glu Val Lys Ala 
    50                  55                  60                  


Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln Glu Glu 
65                  70                  75                  80  


Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu Leu Gln 
                85                  90                  95      


Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu Ser Pro 
            100                 105                 110         


Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp Ala Leu 
        115                 120                 125             


Arg Thr His Leu Ala Pro Tyr Leu Asp Asp Phe Gln Lys Lys Trp Gln 
    130                 135                 140                 


Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro Leu Arg Ala Glu 
145                 150                 155                 160 


Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu Gln Glu Lys Leu 
                165                 170                 175     


Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg Ala His Val Asp 
            180                 185                 190         


Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu Leu Arg Gln Arg 
        195                 200                 205             


Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly Gly Ala Arg Leu 
    210                 215                 220                 


Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser Thr Leu Ser Glu 
225                 230                 235                 240 


Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly Leu Leu Pro Val 
                245                 250                 255     


Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu Glu Glu Tyr Thr 
            260                 265                 270         


Lys Lys Leu Asn Thr Gln 
        275             


<210>  69
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  70
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circular permutated HopQ (cHopQ)

<400>  70

Thr Lys Thr Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn 
1               5                   10                  15      


Leu Leu Thr Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys 
            20                  25                  30          


Pro Ile Leu Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn 
        35                  40                  45              


Ala Asn Thr Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys 
    50                  55                  60                  


Ala Thr Phe Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn 
65                  70                  75                  80  


Ala Gln Lys Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro 
                85                  90                  95      


Lys Asn Ile Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser 
            100                 105                 110         


Leu Thr Ala Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala 
        115                 120                 125             


Glu Ile Leu Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu 
    130                 135                 140                 


Ser Ser Gly His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala 
145                 150                 155                 160 


Ile Ser Ser Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly 
                165                 170                 175     


Asn Gly Cys Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser 
            180                 185                 190         


Ala Ala Asp Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn 
        195                 200                 205             


Leu Ala Asn Thr Leu Ile Gln Glu Leu Gly Asn Asn Pro Phe Arg Ala 
    210                 215                 220                 


Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Lys Leu Ser Asp Thr 
225                 230                 235                 240 


Tyr Glu Gln Leu Ser Arg Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser 
                245                 250                 255     


Lys Thr Ser Ala Gln Ala Ile Asn Gln Ala Val Asn Asn Leu Asn Glu 
            260                 265                 270         


Arg Ala Lys Thr Leu Ala Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln 
        275                 280                 285             


Ala Thr Leu Leu Ala Leu Arg Ser Val Leu Gly Leu Trp Asn Ser Met 
    290                 295                 300                 


Gly Tyr Ala Val Ile Cys Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn 
305                 310                 315                 320 


Asn Gln Lys Asp Phe His Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr 
                325                 330                 335     


Ile Asn Cys Gly Gly Ser Thr Asn Ser Asn Gly Thr His Ser Tyr Asn 
            340                 345                 350         


Gly Thr Asn Thr Leu Lys Ala Asp Lys Asn Val Ser Leu Ser Ile Glu 
        355                 360                 365             


Gln Tyr Glu Lys Ile His Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu 
    370                 375                 380                 


Lys Gln Ala Gly Leu Ala Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu 
385                 390                 395                 400 


Ala His Val Thr Thr Ser Lys Tyr 
                405             


<210>  71
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  circular permutated HopQ wherein the linker and 7 amino acids are
       truncated(c7HopQ)

<400>  71

Thr Lys Thr Thr Thr Ser Val Ile Asp Thr Thr Asn Asp Ala Gln Asn 
1               5                   10                  15      


Leu Leu Thr Gln Ala Gln Thr Ile Val Asn Thr Leu Lys Asp Tyr Cys 
            20                  25                  30          


Pro Ile Leu Ile Ala Lys Ser Ser Ser Ser Asn Gly Gly Thr Asn Asn 
        35                  40                  45              


Ala Asn Thr Pro Ser Trp Gln Thr Ala Gly Gly Gly Lys Asn Ser Cys 
    50                  55                  60                  


Ala Thr Phe Gly Ala Glu Phe Ser Ala Ala Ser Asp Met Ile Asn Asn 
65                  70                  75                  80  


Ala Gln Lys Ile Val Gln Glu Thr Gln Gln Leu Ser Ala Asn Gln Pro 
                85                  90                  95      


Lys Asn Ile Thr Gln Pro His Asn Leu Asn Leu Asn Ser Pro Ser Ser 
            100                 105                 110         


Leu Thr Ala Leu Ala Gln Lys Met Leu Lys Asn Ala Gln Ser Gln Ala 
        115                 120                 125             


Glu Ile Leu Lys Leu Ala Asn Gln Val Glu Ser Asp Phe Asn Lys Leu 
    130                 135                 140                 


Ser Ser Gly His Leu Lys Asp Tyr Ile Gly Lys Cys Asp Ala Ser Ala 
145                 150                 155                 160 


Ile Ser Ser Ala Asn Met Thr Met Gln Asn Gln Lys Asn Asn Trp Gly 
                165                 170                 175     


Asn Gly Cys Ala Gly Val Glu Glu Thr Gln Ser Leu Leu Lys Thr Ser 
            180                 185                 190         


Ala Ala Asp Phe Asn Asn Gln Thr Pro Gln Ile Asn Gln Ala Gln Asn 
        195                 200                 205             


Leu Ala Asn Thr Leu Ile Gln Glu Leu Gly Asn Asn Thr Tyr Glu Gln 
    210                 215                 220                 


Leu Ser Arg Leu Leu Thr Asn Asp Asn Gly Thr Asn Ser Lys Thr Ser 
225                 230                 235                 240 


Ala Gln Ala Ile Asn Gln Ala Val Asn Asn Leu Asn Glu Arg Ala Lys 
                245                 250                 255     


Thr Leu Ala Gly Gly Thr Thr Asn Ser Pro Ala Tyr Gln Ala Thr Leu 
            260                 265                 270         


Leu Ala Leu Arg Ser Val Leu Gly Leu Trp Asn Ser Met Gly Tyr Ala 
        275                 280                 285             


Val Ile Cys Gly Gly Tyr Thr Lys Ser Pro Gly Glu Asn Asn Gln Lys 
    290                 295                 300                 


Asp Phe His Tyr Thr Asp Glu Asn Gly Asn Gly Thr Thr Ile Asn Cys 
305                 310                 315                 320 


Gly Gly Ser Thr Asn Ser Asn Gly Thr His Ser Tyr Asn Gly Thr Asn 
                325                 330                 335     


Thr Leu Lys Ala Asp Lys Asn Val Ser Leu Ser Ile Glu Gln Tyr Glu 
            340                 345                 350         


Lys Ile His Glu Ala Tyr Gln Ile Leu Ser Lys Ala Leu Lys Gln Ala 
        355                 360                 365             


Gly Leu Ala Pro Leu Asn Ser Lys Gly Glu Lys Leu Glu Ala His Val 
    370                 375                 380                 


Thr Thr Ser Lys Tyr 
385                 


