               SEQUENCE LISTING

<110> Intellexon GmbH

<120> HLA-H, HLA-J and HLA-L as therapeutic and diagnostic targets

<130> AC2757 EP

<160> 83

<170> BiSSAP 1.3

<210> 1
<211> 221
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-H soluble

<400> 1
Met Val Leu Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      
Leu Ala Leu Thr Leu Thr Gln Thr Trp Ala Arg Ser His Ser Met Arg 
            20                  25                  30          
Tyr Phe Tyr Thr Thr Met Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe 
        35                  40                  45              
Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser 
    50                  55                  60                  
Asp Asp Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Met Glu Arg 
65                  70                  75                  80  
Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Cys Lys Ala Gln 
                85                  90                  95      
Ala Gln Thr Glu Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr Tyr Asn 
            100                 105                 110         
Gln Ser Glu Gly Gly Ser His Thr Met Gln Val Met Tyr Gly Cys Asp 
        115                 120                 125             
Val Gly Pro Asp Gly Arg Phe Leu Arg Gly Tyr Glu Gln His Ala Tyr 
    130                 135                 140                 
Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr 
145                 150                 155                 160 
Ala Ala Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala 
                165                 170                 175     
Arg Arg Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Phe Val Glu 
            180                 185                 190         
Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala 
        195                 200                 205             
Asp Pro Pro Gln Asp Thr Tyr Asp Pro Pro Pro His Leu 
    210                 215                 220     

<210> 2
<211> 219
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-J soluble

<400> 2
Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Thr Leu Ala Leu 
1               5                   10                  15      
Ala Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          
Val Ser Trp Pro Gly Arg Gly Glu Pro Ser Phe Ile Ala Val Gly Tyr 
        35                  40                  45              
Val Asp Asp Thr Gln Phe Val Arg Val Asp Ser Asp Ala Val Ser Leu 
    50                  55                  60                  
Arg Met Lys Thr Arg Ala Arg Trp Val Glu Gln Glu Gly Pro Glu Tyr 
65                  70                  75                  80  
Trp Asp Leu Gln Thr Leu Gly Ala Lys Ala Gln Ala Gln Thr Asp Arg 
                85                  90                  95      
Val Asn Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Asp 
            100                 105                 110         
Pro Pro Gln Asp Thr Arg Asp Pro Pro Pro Ser Leu Asn Met Arg His 
        115                 120                 125             
Asn Glu Val Leu Gly Ser Gly Leu Leu Pro Cys Gly Asp His Ile Asp 
    130                 135                 140                 
Leu Ala Ala Gly Trp Gly Gly Pro Asp Pro Gly His Gly Ala Arg Gly 
145                 150                 155                 160 
Asp Gln Ala His Arg Gly Trp Asn Leu Pro Glu Val Gly Gly Cys Gly 
                165                 170                 175     
Ser Ala Phe Trp Arg Gly Thr Glu Ile His Met Pro Cys Ala Ala Gln 
            180                 185                 190         
Gly Ala Ala Gln Ala Pro His Pro Glu Met Gly His Thr Phe Leu Glu 
        195                 200                 205             
Thr Ser Arg Gly Ser Lys Thr Arg Arg Phe Leu 
    210                 215                 

<210> 3
<211> 246
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-L soluble

<400> 3
Met Gly Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala 
1               5                   10                  15      
Leu Ala Leu Thr Glu Thr Trp Ala Ala Thr Pro Val Arg Gly Trp Ser 
            20                  25                  30          
Gly Gly Arg Arg Gly Trp Ser Arg Arg Gly Trp Ser Ile Gly Thr Arg 
        35                  40                  45              
Arg His Gly Thr Pro Arg Ala Thr Arg Arg Phe Thr Glu Thr Cys Gly 
    50                  55                  60                  
Pro Cys Ser Ala Ile Thr Thr Arg Ala Arg Pro Val Thr Val Arg Leu 
65                  70                  75                  80  
Arg Trp Gln Gly Leu His Arg Pro Glu Arg Gly Pro Ala Leu Leu Asp 
                85                  90                  95      
Arg Arg Glu His Ser Gly Ser Asp Leu Pro Ala Gln Val Gly Ser Gly 
            100                 105                 110         
Gln Ile Leu Arg Ala Gly Gln Gly Leu Pro Glu Gly Lys Cys Met Glu 
        115                 120                 125             
Trp Leu Arg Arg His Leu Glu Asn Gly Lys Glu Thr Leu Gln His Ala 
    130                 135                 140                 
Asp Pro Pro Lys Ala His Val Thr Gln His Pro Ile Ser Asp His Glu 
145                 150                 155                 160 
Ala Thr Leu Arg Cys Trp Ala Leu Gly Leu Tyr Pro Ala Glu Ile Thr 
                165                 170                 175     
Leu Thr Trp Gln Gln Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu 
            180                 185                 190         
Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Val Ala 
        195                 200                 205             
Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Met Cys His Val Gln 
    210                 215                 220                 
His Glu Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser 
225                 230                 235                 240 
Gln Pro Thr Ile Pro Ile 
                245     

<210> 4
<211> 111
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-V soluble

<400> 4
Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala Leu Val Leu 
1               5                   10                  15      
Thr Gln Thr Trp Ala Gly Phe His Ser Leu Arg Tyr Phe His Thr Thr 
            20                  25                  30          
Met Ser Arg Pro Gly Arg Ala Asp Pro Arg Phe Leu Ser Val Gly Asp 
        35                  40                  45              
Val Asp Asp Thr Gln Cys Val Arg Leu Asp Ser Asp Ala Thr Ser Pro 
    50                  55                  60                  
Arg Met Glu Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr 
65                  70                  75                  80  
Trp Glu Glu Glu Thr Gly Thr Ala Lys Ala Lys Ala Gln Phe Tyr Arg 
                85                  90                  95      
Val Asn Leu Arg Thr Leu Ser Gly Tyr Tyr Asn Gln Ser Glu Ala 
            100                 105                 110     

<210> 5
<211> 206
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-Y soluble

<400> 5
Met Ala Val Val Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      
Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          
Ser Thr Ser Val Ser Arg Pro Gly Ser Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              
Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  
Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Met Glu Gln Glu Glu 
65                  70                  75                  80  
Pro Glu Tyr Trp Asp Arg Gln Thr Gln Ile Ser Lys Thr Asn Ala Gln 
                85                  90                  95      
Ile Asp Leu Glu Ser Leu Arg Ile Ala Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         
Glu Ala Gly Ser His Thr Ile Gln Arg Met Ser Gly Cys Asp Val Gly 
        115                 120                 125             
Ser Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 
Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 
Asp Met Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Gln 
                165                 170                 175     
Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Met Glu Trp Leu 
            180                 185                 190         
Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr 
        195                 200                 205     

<210> 6
<211> 1704
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-H soluble

<400> 6
agtttctctt cttctcacaa cctgcgacgg gtccttcttc cttgatactc acgaagcgga      60

cacagttctc attcccacta ggtgtcgggt ttctagagaa gccaatcggt gccgccgcgg     120

tcccggttct aaagtcccca cgcacccacc gggactcaga ttctccccag acgccgagga     180

tggtgctcat ggcgccccga accctcctcc tgctgctctc aggggccctg gccctgaccc     240

tgacccagac ctgggcgcgc tcccactcca tgaggtattt ctacaccacc atgtcccggc     300

ccggccgcgg ggagccccgc ttcatctccg tcggctacgt ggacgatacg cagttcgtgc     360

ggttcgacag cgacgacgcg agtccgagag aggagccgcg ggcgccgtgg atggagcggg     420

aggggccaga gtattgggac cggaacacac agatctgcaa ggcccaggca cagactgaac     480

gagagaacct gcggatcgcg ctccgctact acaaccagag cgagggcggt tctcacacca     540

tgcaggtgat gtatggctgc gacgtggggc ccgacgggcg cttcctccgc gggtatgaac     600

agcacgccta cgacggcaag gattacatcg ccctgaacga ggacctgcgc tcctggaccg     660

cggcggacat ggcagctcag atcaccaagc gcaagtggga ggcggcccgt cgggcggagc     720

agctgagagc ctacctggag ggcgagttcg tggagtggct ccgcagatac ctggagaacg     780

ggaaggagac gctgcagcgc gcggaccccc cccaagacac atatgaccca ccaccccatc     840

tctgaccatg aggccaccct gaggtgctgg gccctgggct tctaccctgc ggagatcaca     900

ctgacctggc agcgggatgg ggaggaccag acccaggaca cggagctcgt ggagaccagg     960

cctgcagggg atggaacctt ccagaagtgg gcggctgtgg tggtgccttc tggagaggag    1020

cagagataca cctgccatgt gcagcatgag ggtctgcccg agcccctcac cctgagatgg    1080

gagccatctt cccagcccaa cgtccccatc gtgggcatcg ttgctggcct ggttctactt    1140

gtagctgtgg tcactggagc tgtggtcgct gctgtaatgt ggaggaagaa gagctcagat    1200

agaaaaggag ggagctactc tcaggctgca acagcaacag tgcccagggc tctgatgtgt    1260

ctctcacggc ttgaaagtgt gagacagctg ccttgtgtgg gactgagagg caagagttgt    1320

tcctgccttc cctttgtgac ttgaagaacc ctgactttct ttctacaaag gcacctgaat    1380

gtgtctgtgt tcctgtaggc ataatgtgtg gaggagggga gaccaaccca ccctcatgtc    1440

caccatgacc ctcttcccca cgctgatctg tgttccctcc ccaatcatct ttcctgttcc    1500

agagaggagg ggctgagatg tctccatctt tttctcaact ttatgtgcac tgagctgtaa    1560

cttcttactt ccctcttaaa attagaatct gagtaaacat ttactttttc aaattcttgc    1620

catgagaggt tgatgactta attaaaggag aagattccta aaatttgaga gacaaaataa    1680

atggaacaca tgagaacctt ccag                                           1704


<210> 7
<211> 1552
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-J soluble

<400> 7
ctatactatc tcatgcaccc aggcacaact tttccagatt taaagaaaaa gaaaaaagaa      60

ataaaagaaa aaaacctctg tctctacacc tccattccca gggagagctc cctctctggc     120

accaagctcc ctggggtgag ttttcttttt gaagagtcca ggggaacagc ctgcgacggg     180

tccttcttcc tggacactca cgacgcggac ccagttctca ctcccactga gtgtcgggtt     240

ttagggaagc caatcagcgt cgcgcggccc cggttctaaa gtccccacgc acccaccggg     300

actcggagtc tccccagacg ccgacgatgg ggtcatggcg ccccgaaccc tcctcctgct     360

gctctcgggg accctggccc tggccgagac ctgggcgggc tcccactcca tgaggtattt     420

cagcaccgcc gtttcctggc cgggccgcgg ggagcccagc ttcattgccg tgggctacgt     480

ggacgacacg cagttcgtgc gggtcgacag tgacgccgtg agtctgagga tgaagacgcg     540

ggcgcggtgg gtggagcagg aggggccgga gtattgggac ctacagacac tgggcgccaa     600

ggcccaggca cagactgacc gagtgaacct gcggaccctg ctccgctact acaaccagag     660

cgaggcggac cccccccaag acacacgtga cccacccccc tctctgaaca tgaggcataa     720

cgaggtcctg ggttctgggc ttctaccctg cggagatcac attgacctgg cagcgggatg     780

gggaggacca gacccaggac atggagctcg tggagaccag gcccacaggg gatggaacct     840

tccagaagtg ggcggttgtg gtagtgcctt ctggagagga acagagatac acatgccatg     900

tgcagcacaa ggggctgccc aagcccctca tcctgagatg ggtcacacat ttctggaaac     960

ttctcaaggt tccaagacta ggaggttcct ctaggacctc atggccctgc taccttcctg    1020

gcctctcaca ggacgttttc ttcccgcaga tagaaaagga gggagctact ctcaggctgc    1080

aagcagccaa agtgcccagg gctctgatgt gtctctcacg gcttgtaaag tgtgagacag    1140

ctgccttgtg tgggactgag aggcaagatt tgttcatgcc ttccctttgt gacttcaaga    1200

accctgactt ctctttctgc aaaggcatct gaatgtgtct gtgtccctat aggcataatg    1260

tgaggtggtg gggagaccag cccacacccg tgtccaccat gaccctgttc cccacactga    1320

cctacattcc ttccccgatc acctttcctg ttccagagaa gtggtgctgg gatgtctcca    1380

tctctgtctc aacttcatgg tgcactgagc tgtaacttct tacttcccta ttaaaattag    1440

aatctgagta taaatttact tttttcaaat tatttccatg acgggttgat gggttaatta    1500

aaggagaaga ttcctaaaat ttgagagaca aaataaatgg aagacatgag aa            1552


<210> 8
<211> 898
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-L soluble

<400> 8
acgatcccgg cactacagtc ccggcgcaac cacccgcact cagattctcc ccaaacgcca      60

aggatggggg tcatggctcc ccgaaccctc ctcctgctgc tcttgggggc cctggccctg     120

accgagacct gggccgcgac tccgtgagtc cgaggatgga gcggcgggcg ccgtgggtgg     180

agcaggaggg gctggagtat tgggaccagg agacacggaa cgccaagggc cacgcgcaga     240

tttaccgagt gaacctgcgg accctgctcc gctattacaa ccagagcgag gccggtatga     300

acagttcgcc tacgatggca aggattacat cgccctgaac gaggacctgc actcctggac     360

cgccgcgaac acagcggctc agatctccca gcacaagtgg gaagcggaca aatactcaga     420

gcaggtcagg gcctacctga gggcaagtgc atggagtggc tccgcagaca cctggagaac     480

gggaaggaga cgctgcagca cgcggatccc ccaaaggcac atgtgaccca gcaccccatc     540

tctgaccatg aggccaccct gaggtgctgg gccctgggcc tctaccctgc ggagatcaca     600

ctgacctggc agcaggatgg ggaggaccag acccaggaca cggagcttgt ggagaccagg     660

cctgcagggg acggaacctt ccagaagtgg gtggctgtag tggtgccttc cggagaggag     720

cagagataca tgtgccatgt gcagcatgag gggctgccag agcccctcac cctgagatgg     780

gagccgtctt ctcagcccac catccccatc gtgggcatcg ttgctggcct gtttctcctt     840

ggagctgtgg tcactggagc tgtggttgct gctgcgatgt ggaggaagaa aagctcag       898


<210> 9
<211> 1285
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-V soluble

<400> 9
gaaacattga gacagagcgc ttggcacaga agtagcgggg tcagggcgaa gtcccagggc      60

ctcaggcgtg gctctcagga tctcaggccc caaaggcggt gtatggattg gggaggccca     120

gcgctgggca ttccccatct ttgcagggtt tctcttctcc ctctcccaac ctgtgtcggg     180

tccttcttcc tgggtactca ccgggctgcc ccagttctca ctcccattga gtgtcgggtt     240

tctagagaag ccaatcaatg tagccgcggt cccggttcta aagttcccac gcacccaccg     300

ggactccgat tcttcccagt cgccgaggat ggtgtcatgg cgccccgaac cctgcttctg     360

ctgctctcgg gggccctggt cctgacccag acctgggcag gcttccactc cttgaggtat     420

ttccacacca ccatgtcccg gcccggccgc gcggatcccc gcttcctctc cgtgggcgac     480

gtggacgaca cgcagtgcgt gcggctcgac agcgacgcca cgagtcccag gatggagccg     540

cgggcgccgt ggatggagca ggaggggccg gaatattggg aagaggagac agggaccgcc     600

aaggccaaag cacagtttta ccgagtgaac ctgcggaccc tgagcggcta ctacaaccag     660

agtgaggcct aagtgcagct tcattccctc cctgttcgtg tggcctggac ttaatgactc     720

acttctaact gatagagtaa tgctgacata atagtttgtg attctgggtg tagaacataa     780

gactcactga agtttctact ttggttcttt ctttctctgg aatcatgagc cctgggggaa     840

gctggctgtt gtgtcataag gaggcctgtg gtccatgtga ctaggaagtg agtcctcctg     900

ggaccagaca ataagaagct aaagcctctt ccaaaagcca tgtgagagat tcttgtgtct     960

tgtgaatccc cggccccatt tgagccctca gatgattcag ccctggaaga caactagact    1020

gcaacgttgt gagaggccct gagccagaag cattcagaga aacttctcct ggattcctga    1080

ccatggataa ctgtgggaga tgataaatat ttgttgattt gagctgctaa gttgtaggtg    1140

acttgttatg cagcagtaga taactaatac agcttcacaa gagaggatga atcactgaac    1200

tttttcattt gctctaaatt cattataaga tattaaacat gtcatttgct tttaatattt    1260

aataaaaatt tccatggcta tataa                                          1285


<210> 10
<211> 1095
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-Y soluble

<400> 10
atggcggtcg tggcgccccg aaccctcctc ctgctactct cgggggccct ggccctgacc      60

cagacctggg cgggctccca ctccatgagg tatttctcca catccgtgtc ccggcccggc     120

agtggagagc cccgcttcat cgcagtgggc tacgtggacg acacgcagtt cgtgcggttc     180

gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggatgga gcaggaggag     240

ccggagtatt gggaccggca gacacagatc tccaagacca acgcacagat tgacctagag     300

agcctgcgga tcgcgctccg ctactacaac cagagcgagg ccggttctca caccatccag     360

aggatgtctg gctgcgacgt ggggtcggac gggcgcttcc tccgcgggta ccggcaggac     420

gcctacgacg gcaaggatta catcgccctg aacgaggacc tgcgctcttg gaccgcggcg     480

gacatggcgg ctcagatcac ccagcgcaag tgggaggcgg cccgtcaggc ggagcagttg     540

agagcctacc tggagggcga gtgcatggag tggctccgca gatacctgga gaacgggaag     600

gagacgctgc agcgcacgga ccccccccca agacacatat gacccaccac cccatctctg     660

accatgaggc caccctgagg tgctgggccc tgagcttcta ccctgcggag atcacactga     720

cctggcagcg ggatggggag gaccagaccc aggacacgga gctcgtggag accaggcctg     780

caggggatgg aaccttccag aagtgggcgt ctgtggtggt gccttctgga caggagcaga     840

gatacacctg ccatgtgcag catgagggtc tgcccaagcc cctcaccctg agatgggagc     900

cgtcttccca gcccaccatc cccatcgtgg gcatccttgc tggcctggtt ctctttggag     960

ctgtgatcgc tggagctgtg gtcgctgctg tgatgtggag gaggaagagc tcagatagaa    1020

aaggagggag ctactctcag gctgcaagca gtgacagtgc ccagggctct gatgtgtctc    1080

tcacagcttg taaag                                                     1095


<210> 11
<211> 341
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-L membrane-bound

<400> 11
Met Gly Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala 
1               5                   10                  15      
Leu Ala Leu Thr Glu Thr Trp Ala Ala Thr Pro Val Arg Gly Trp Ser 
            20                  25                  30          
Gly Gly Arg Arg Gly Trp Ser Arg Arg Gly Trp Ser Ile Gly Thr Arg 
        35                  40                  45              
Arg His Gly Thr Pro Arg Ala Thr Arg Arg Phe Thr Glu Thr Cys Gly 
    50                  55                  60                  
Pro Cys Ser Ala Ile Thr Thr Arg Ala Arg Pro Val Thr Val Arg Leu 
65                  70                  75                  80  
Arg Trp Gln Gly Leu His Arg Pro Glu Arg Gly Pro Ala Leu Leu Asp 
                85                  90                  95      
Arg Arg Glu His Ser Gly Ser Asp Leu Pro Ala Gln Val Gly Ser Gly 
            100                 105                 110         
Gln Ile Leu Arg Ala Gly Gln Gly Leu Pro Glu Gly Lys Cys Met Glu 
        115                 120                 125             
Trp Leu Arg Arg His Leu Glu Asn Gly Lys Glu Thr Leu Gln His Ala 
    130                 135                 140                 
Asp Pro Pro Lys Ala His Val Thr Gln His Pro Ile Ser Asp His Glu 
145                 150                 155                 160 
Ala Thr Leu Arg Cys Trp Ala Leu Gly Leu Tyr Pro Ala Glu Ile Thr 
                165                 170                 175     
Leu Thr Trp Gln Gln Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu 
            180                 185                 190         
Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Val Ala 
        195                 200                 205             
Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Met Cys His Val Gln 
    210                 215                 220                 
His Glu Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser 
225                 230                 235                 240 
Gln Pro Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Phe Leu Leu 
                245                 250                 255     
Gly Ala Val Val Thr Gly Ala Val Val Ala Ala Ala Met Trp Arg Lys 
            260                 265                 270         
Lys Ser Ser Gly Ser Asn Cys Ala Gln Tyr Ser Asp Ala Ser His Asp 
        275                 280                 285             
Thr Cys Lys Glu Asp Tyr Ala Cys Ser Cys Ser Gly Val Cys Val Leu 
    290                 295                 300                 
Ile Ser Phe Ser Pro Gly Cys Pro Ser Ser Leu Thr Ala Ala Gly Val 
305                 310                 315                 320 
Ile Phe Pro Val Ile Asn Pro Thr Arg Trp Lys Ala Ala Pro Ala His 
                325                 330                 335     
Arg Ser Leu Trp Tyr 
            340     

<210> 12
<211> 4622
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-L membrane-bound

<400> 12
acgatcccgg cactacagtc ccggcgcaac cacccgcact cagattctcc ccaaacgcca       60

aggatggggg tcatggctcc ccgaaccctc ctcctgctgc tcttgggggc cctggccctg      120

accgagacct gggccgcgac tccgtgagtc cgaggatgga gcggcgggcg ccgtgggtgg      180

agcaggaggg gctggagtat tgggaccagg agacacggaa cgccaagggc cacgcgcaga      240

tttaccgagt gaacctgcgg accctgctcc gctattacaa ccagagcgag gccggtatga      300

acagttcgcc tacgatggca aggattacat cgccctgaac gaggacctgc actcctggac      360

cgccgcgaac acagcggctc agatctccca gcacaagtgg gaagcggaca aatactcaga      420

gcaggtcagg gcctacctga gggcaagtgc atggagtggc tccgcagaca cctggagaac      480

gggaaggaga cgctgcagca cgcggatccc ccaaaggcac atgtgaccca gcaccccatc      540

tctgaccatg aggccaccct gaggtgctgg gccctgggcc tctaccctgc ggagatcaca      600

ctgacctggc agcaggatgg ggaggaccag acccaggaca cggagcttgt ggagaccagg      660

cctgcagggg acggaacctt ccagaagtgg gtggctgtag tggtgccttc cggagaggag      720

cagagataca tgtgccatgt gcagcatgag gggctgccag agcccctcac cctgagatgg      780

gagccgtctt ctcagcccac catccccatc gtgggcatcg ttgctggcct gtttctcctt      840

ggagctgtgg tcactggagc tgtggttgct gctgcgatgt ggaggaagaa aagctcaggc      900

agcaattgtg ctcagtactc tgatgcatct catgatactt gtaaagagga ctatgcctgt      960

tcctgttctg gtgtctgcgt tctgatctct ttctcccctg ggtgtccctc atctctgaca     1020

gcagcaggag tcatttttcc tgtcattaac cccacaaggt ggaaggcagc ccctgcacac     1080

agaagtctgt ggtattaaga gatgaatttt caagcccgtg cagcttttac cctatttcca     1140

gggctctttc ttggattgta ttttctatct tttccccaac ctttttaaag gaactagatt     1200

ctgaaattag cagagaagag ggatgccaca agttctcatc ttaggtaact ttctagtgga     1260

actcctcttc tgctcagctc tcctacccac tctcccttcc ctgagttgta gtaatcctag     1320

cactggctct aatgcaaact catggatcta taaagcaaag tctaacttag atttatattt     1380

gtttggaaat tgggattcat agtcaaagat tgttctttcc taagagggaa atataattgc     1440

atgctgcagt gtgcagaggg ttggtgtgaa ggagggatgc agggaggaag ggagggagga     1500

cacacaagca gcactgctgg gaaaagcaca ggcggcctgg atgtcagtgt gaggggacct     1560

tgtgctgtcg ttgctgcaaa accgcatttg gcctgaggct atgttaataa agatactgcc     1620

tttagaatag gaggtgctct acagtgatga ttcattcagc cgacatttgc tgtctgccag     1680

acatatgaca gaatgttttt gcatctgggg aaagtcattg aagtaaaatc agaaaaatct     1740

ctagccttgt ggagcatgtg ttccagtggg aagaggcaga cggtacatac actctaatat     1800

atgcagagta aatgaggaaa gtgttagaag gtgataagtg ctgtggaaca ggtgatcaga     1860

gtatgggttg tgggacagag aaggtagcta ttgtgccggg gttgtcagcg tgggccttgt     1920

tgggaaggtg acctttgatg aaatatttga aggacataaa ggaatttgtc atgagggtat     1980

ctggaagaag ttttttctag ggagtaggaa ccttcagtgt cagtgtacca gggcaggatc     2040

atgtctgtgt gttctgggaa gaacacggga tcgggtatgg ctagagcaga gagtcactga     2100

gataaggtca ggggtttggt cagatcatgt gggcataggg ctcaagtatg tgggaaggat     2160

tttgattttg aatgagatag ttttaagcag aataaagaca tgccacaact tctcttttaa     2220

aaggatcact gtagctgctc tgctgagaac agaatccaaa ggccggcgat gagcaaggca     2280

ggtgggaaaa ctgtaggaaa tgagtgcagt atttcaggct ggagatgtcg gttacttcaa     2340

ctggggtgtg agcagtggaa atagtgggac gtgattggat tcctactatt tccaatcact     2400

ttataccgca ttttctaatg gactaaatct ggggtatgag aaagaagagt aaaggatacc     2460

aaaaatgtca gactgtgact aaaaagagtt gccatcagct gagaatgaga agactagcag     2520

gagcatatga gaggagggga cgtcgcaggc agtcactatg ggagacgtgg gatctgagat     2580

gccgctgaga aataccagtg aggtagtcgg gttggcagtt ggacagatga atctggagac     2640

atttaggaga aatagacttg ggaggtgatg tcatataaca gttatttaaa gccttgagtc     2700

tgaatgacgt ctccaaggga gtgattggct gtagaagaga acaggaacaa ggactgaaca     2760

ctaggcctct gttgctaaag gatctgatca gacaacacac ctagatcaga ctgcacagtc     2820

ctgaccccac atctagaagg tacatagacc agggagttct agactttcct gtggacagga     2880

atcacctgga catcacctta agtctaagct gatctggaat cgagaatgag atttcctact     2940

tatataatgt tgctgttggc gctgatgctg ctggtcttca gatcccactt ttggtagcaa     3000

gaacacagac caggattcct aggctatgca tcagcctcgc ctgtgaggct tgttaataag     3060

caattcctgc actccatgcg caacattctg acacaggggc atctgtggag aggcctgagt     3120

attctacaac aagcccacag caaacctggt gctcagccag atttgatatc actgagatca     3180

gtagttggag aatgcccagg atggggaggg gtctcagacc cacatttaag tgttgcttta     3240

ttctgggttt tttatttatt tatttattta tttttaagga ggatgtgttt ctttaattat     3300

aagacaggat gctgagagat aaatgtcatt ttctctatca tggggtatag ccagatggaa     3360

gattgagaag tggctcacag ctcagcagaa tgaaaaaata tctgaatgct gctttctgaa     3420

actactctcc agaatgattt cacactcact ccttggagca aacaatgact tgcaaatttt     3480

tctaatttaa acataaagga gtgtacatat tggtattagt attcatttta ttttggggaa     3540

gggcactgta ttagtccata gtccgttttc acactgccga taaagacata cccaacattg     3600

ggaagaaaaa gaggtttaat tggacttaca gttccatttg gctggggagg cctcagaatc     3660

atggtgggag gcgaaaggca cttcttacat ggtggtggca agagaaaatg aggaagaagc     3720

aaatgccaaa acccctgata aacacattgg atctcaggag acttattcat tatcatgaga     3780

atagcatggg aaagactggc ccccatgatt caattacctc cccctgggtc cctcccacaa     3840

catgtgggaa ttctgggaga tacaattcaa gttgagattt gggtggggac acagccaaac     3900

cacattggac acagaaccag gtttgaagct acacagccag gaacataatc cacagccacc     3960

ctaattcaga tctctcatag gaaccactgt ccctgctcct gagcacagat gctactgcat     4020

atacctctga taccctgatg gccgacactg ggccctgtgg caaagactgc tatcactgct     4080

gctcctgaga actgctccac tactgctcct cagccatctt taccaaaatg cagtatttac     4140

tgtcccagcc tctctgtgtc atctcatcct gattagaagc ccacatgtgg ttatctaaat     4200

tgtgcagcca aagcctcttg cagtgtttaa ctgcaataat gttggggaaa gtgaattttt     4260

ctcctttgta gaaggaggta gtccctgcct tctaataaga ctcttcaaca taggaagaga     4320

attcagttgc tggaggtaga ggggtgaggg atggaaaaag aatgacaaat ttcaattcct     4380

agaatcatgt tctgagacta gaactttatc tagtacattg caggcacctg ggtttggttg     4440

agtgtataat aaatgacata gttcaactta ttcccttgac agtttgtttt ggggtccagc     4500

ttttgtctac cccagttttc acacacagat acgtggagaa gcattgtgtg atggtaaaat     4560

gtttacttga aagccttttt ccctatcttt gtctcttgct aggattaaaa acccgtatct     4620

gt                                                                    4622


<210> 13
<211> 357
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-E

<400> 13
Met Val Asp Gly Thr Leu Leu Leu Leu Leu Ser Glu Ala Leu Ala Leu 
1               5                   10                  15      
Thr Gln Thr Trp Ala Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser 
            20                  25                  30          
Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr 
        35                  40                  45              
Val Asp Asp Thr Gln Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro 
    50                  55                  60                  
Arg Met Val Pro Arg Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr 
65                  70                  75                  80  
Trp Asp Arg Glu Thr Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg 
                85                  90                  95      
Val Asn Leu Arg Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         
Ser His Thr Leu Gln Trp Met His Gly Cys Glu Leu Gly Pro Asp Gly 
        115                 120                 125             
Arg Phe Leu Arg Gly Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 
Leu Thr Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala 
145                 150                 155                 160 
Ala Gln Ile Ser Glu Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His 
                165                 170                 175     
Gln Arg Ala Tyr Leu Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr 
            180                 185                 190         
Leu Glu Lys Gly Lys Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr 
        195                 200                 205             
His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 
Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln 
225                 230                 235                 240 
Asp Gly Glu Gly His Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     
Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser 
            260                 265                 270         
Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             
Glu Pro Val Thr Leu Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro 
    290                 295                 300                 
Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ser Val Val Ser 
305                 310                 315                 320 
Gly Ala Val Val Ala Ala Val Ile Trp Arg Lys Lys Ser Ser Gly Gly 
                325                 330                 335     
Lys Gly Gly Ser Tyr Ser Lys Ala Glu Trp Ser Asp Ser Ala Gln Gly 
            340                 345                 350         
Ser Glu Ser His Ser 
        355         

<210> 14
<211> 442
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-F1

<400> 14
Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      
Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          
Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              
Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  
Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  
Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      
Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         
Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             
Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 
Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 
Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     
Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         
Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala 
        195                 200                 205             
His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 
Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
225                 230                 235                 240 
Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     
Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Pro 
            260                 265                 270         
Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             
Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 
    290                 295                 300                 
Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr 
305                 310                 315                 320 
Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg 
                325                 330                 335     
Asn Arg Gly Ser Tyr Ser Gln Ala Ala Ala Tyr Ser Val Val Ser Gly 
            340                 345                 350         
Asn Leu Met Ile Thr Trp Trp Ser Ser Leu Phe Leu Leu Gly Val Leu 
        355                 360                 365             
Phe Gln Gly Tyr Leu Gly Cys Leu Arg Ser His Ser Val Leu Gly Arg 
    370                 375                 380                 
Arg Lys Val Gly Asp Met Trp Ile Leu Phe Phe Leu Trp Leu Trp Thr 
385                 390                 395                 400 
Ser Phe Asn Thr Ala Phe Leu Ala Leu Gln Ser Leu Arg Phe Gly Phe 
                405                 410                 415     
Gly Phe Arg Arg Gly Arg Ser Phe Leu Leu Arg Ser Trp His His Leu 
            420                 425                 430         
Met Lys Arg Val Gln Ile Lys Ile Phe Asp 
        435                 440         

<210> 15
<211> 346
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-F2

<400> 15
Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      
Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          
Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              
Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  
Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  
Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      
Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         
Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             
Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 
Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 
Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     
Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         
Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala 
        195                 200                 205             
His Val Ala His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys 
    210                 215                 220                 
Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg 
225                 230                 235                 240 
Asp Gly Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro 
                245                 250                 255     
Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Pro 
            260                 265                 270         
Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro 
        275                 280                 285             
Gln Pro Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro 
    290                 295                 300                 
Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr 
305                 310                 315                 320 
Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg 
                325                 330                 335     
Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val 
            340                 345     

<210> 16
<211> 254
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-F3

<400> 16
Met Ala Pro Arg Ser Leu Leu Leu Leu Leu Ser Gly Ala Leu Ala Leu 
1               5                   10                  15      
Thr Asp Thr Trp Ala Gly Ser His Ser Leu Arg Tyr Phe Ser Thr Ala 
            20                  25                  30          
Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr 
        35                  40                  45              
Val Asp Asp Thr Gln Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro 
    50                  55                  60                  
Arg Met Glu Pro Arg Glu Pro Trp Val Glu Gln Glu Gly Pro Gln Tyr 
65                  70                  75                  80  
Trp Glu Trp Thr Thr Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg 
                85                  90                  95      
Val Ala Leu Arg Asn Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly 
            100                 105                 110         
Ser His Thr Leu Gln Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly 
        115                 120                 125             
Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 
Ile Ser Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val 
145                 150                 155                 160 
Ala Gln Ile Thr Gln Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu 
                165                 170                 175     
Phe Arg Thr Tyr Leu Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr 
            180                 185                 190         
Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Gln Ser Pro Gln 
        195                 200                 205             
Pro Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Val Val Leu Gly 
    210                 215                 220                 
Ala Val Val Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Lys Lys 
225                 230                 235                 240 
Ser Ser Asp Arg Asn Arg Gly Ser Tyr Ser Gln Ala Ala Val 
                245                 250                 

<210> 17
<211> 337
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-G1

<400> 17
Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      
Leu Thr Leu Thr Glu Thr Trp Ala Ser His Ser Met Arg Tyr Phe Ser 
            20                  25                  30          
Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met 
        35                  40                  45              
Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala 
    50                  55                  60                  
Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro 
65                  70                  75                  80  
Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr 
                85                  90                  95      
Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
            100                 105                 110         
Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly Ser 
        115                 120                 125             
Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys 
    130                 135                 140                 
Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp 
145                 150                 155                 160 
Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val Ala 
                165                 170                 175     
Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His 
            180                 185                 190         
Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro Pro 
        195                 200                 205             
Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr Leu 
    210                 215                 220                 
Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr Trp 
225                 230                 235                 240 
Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu Thr 
                245                 250                 255     
Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val 
            260                 265                 270         
Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly 
        275                 280                 285             
Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser Ser Leu Pro Thr 
    290                 295                 300                 
Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala Val 
305                 310                 315                 320 
Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser Ser 
                325                 330                 335     
Asp 
    

<210> 18
<211> 245
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-G2

<400> 18
Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      
Leu Thr Leu Thr Glu Thr Trp Ala Ser His Ser Met Arg Tyr Phe Ser 
            20                  25                  30          
Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met 
        35                  40                  45              
Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala 
    50                  55                  60                  
Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro 
65                  70                  75                  80  
Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr 
                85                  90                  95      
Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
            100                 105                 110         
Ala Asp Pro Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr 
        115                 120                 125             
Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile 
    130                 135                 140                 
Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu 
145                 150                 155                 160 
Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala 
                165                 170                 175     
Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val 
            180                 185                 190         
Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Lys Gln Ser 
        195                 200                 205             
Ser Leu Pro Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val 
    210                 215                 220                 
Leu Ala Ala Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg 
225                 230                 235                 240 
Lys Lys Ser Ser Asp 
                245 

<210> 19
<211> 129
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-G3

<400> 19
Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      
Leu Thr Leu Thr Glu Thr Trp Ala Ser His Ser Met Arg Tyr Phe Ser 
            20                  25                  30          
Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met 
        35                  40                  45              
Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala 
    50                  55                  60                  
Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro 
65                  70                  75                  80  
Glu Tyr Trp Glu Glu Glu Thr Arg Asn Lys Gln Ser Ser Leu Pro Thr 
                85                  90                  95      
Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val Leu Ala Ala Val 
            100                 105                 110         
Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg Lys Lys Ser Ser 
        115                 120                 125             
Asp 
    

<210> 20
<211> 245
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-G4

<400> 20
Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      
Leu Thr Leu Thr Glu Thr Trp Ala Ser His Ser Met Arg Tyr Phe Ser 
            20                  25                  30          
Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met 
        35                  40                  45              
Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala 
    50                  55                  60                  
Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro 
65                  70                  75                  80  
Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr 
                85                  90                  95      
Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
            100                 105                 110         
Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly Ser 
        115                 120                 125             
Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys 
    130                 135                 140                 
Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp 
145                 150                 155                 160 
Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val Ala 
                165                 170                 175     
Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His 
            180                 185                 190         
Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Lys Gln Ser 
        195                 200                 205             
Ser Leu Pro Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Val Val 
    210                 215                 220                 
Leu Ala Ala Val Val Thr Gly Ala Ala Val Ala Ala Val Leu Trp Arg 
225                 230                 235                 240 
Lys Lys Ser Ser Asp 
                245 

<210> 21
<211> 318
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-G5

<400> 21
Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      
Leu Thr Leu Thr Glu Thr Trp Ala Ser His Ser Met Arg Tyr Phe Ser 
            20                  25                  30          
Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met 
        35                  40                  45              
Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala 
    50                  55                  60                  
Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro 
65                  70                  75                  80  
Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr 
                85                  90                  95      
Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
            100                 105                 110         
Ala Ser Ser His Thr Leu Gln Trp Met Ile Gly Cys Asp Leu Gly Ser 
        115                 120                 125             
Asp Gly Arg Leu Leu Arg Gly Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys 
    130                 135                 140                 
Asp Tyr Leu Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp 
145                 150                 155                 160 
Thr Ala Ala Gln Ile Ser Lys Arg Lys Cys Glu Ala Ala Asn Val Ala 
                165                 170                 175     
Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu His 
            180                 185                 190         
Arg Tyr Leu Glu Asn Gly Lys Glu Met Leu Gln Arg Ala Asp Pro Pro 
        195                 200                 205             
Lys Thr His Val Thr His His Pro Val Phe Asp Tyr Glu Ala Thr Leu 
    210                 215                 220                 
Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Ile Leu Thr Trp 
225                 230                 235                 240 
Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu Leu Val Glu Thr 
                245                 250                 255     
Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val 
            260                 265                 270         
Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly 
        275                 280                 285             
Leu Pro Glu Pro Leu Met Leu Arg Trp Ser Lys Glu Gly Asp Gly Gly 
    290                 295                 300                 
Ile Met Ser Val Arg Glu Ser Arg Ser Leu Ser Glu Asp Leu 
305                 310                 315             

<210> 22
<211> 226
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-G6

<400> 22
Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      
Leu Thr Leu Thr Glu Thr Trp Ala Ser His Ser Met Arg Tyr Phe Ser 
            20                  25                  30          
Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met 
        35                  40                  45              
Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala 
    50                  55                  60                  
Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro 
65                  70                  75                  80  
Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr 
                85                  90                  95      
Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
            100                 105                 110         
Ala Asp Pro Pro Lys Thr His Val Thr His His Pro Val Phe Asp Tyr 
        115                 120                 125             
Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile 
    130                 135                 140                 
Ile Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Val Glu 
145                 150                 155                 160 
Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala 
                165                 170                 175     
Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val 
            180                 185                 190         
Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu Arg Trp Ser Lys Glu 
        195                 200                 205             
Gly Asp Gly Gly Ile Met Ser Val Arg Glu Ser Arg Ser Leu Ser Glu 
    210                 215                 220                 
Asp Leu 
225     

<210> 23
<211> 115
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-G7

<400> 23
Met Val Val Met Ala Pro Arg Thr Leu Phe Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      
Leu Thr Leu Thr Glu Thr Trp Ala Ser His Ser Met Arg Tyr Phe Ser 
            20                  25                  30          
Ala Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Met 
        35                  40                  45              
Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ser Ala 
    50                  55                  60                  
Cys Pro Arg Met Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly Pro 
65                  70                  75                  80  
Glu Tyr Trp Glu Glu Glu Thr Arg Asn Thr Lys Ala His Ala Gln Thr 
                85                  90                  95      
Asp Arg Met Asn Leu Gln Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
            100                 105                 110         
Ala Ser Glu 
        115 

<210> 24
<211> 2548
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-E

<400> 24
ctcaggactc agaggctggg atcatggtag atggaaccct ccttttactc ctctcggagg      60

ccctggccct tacccagacc tgggcgggct cccactcctt gaagtatttc cacacttccg     120

tgtcccggcc cggccgcggg gagccccgct tcatctctgt gggctacgtg gacgacaccc     180

agttcgtgcg cttcgacaac gacgccgcga gtccgaggat ggtgccgcgg gcgccgtgga     240

tggagcagga ggggtcagag tattgggacc gggagacacg gagcgccagg gacaccgcac     300

agattttccg agtgaatctg cggacgctgc gcggctacta caatcagagc gaggccgggt     360

ctcacaccct gcagtggatg catggctgcg agctggggcc cgacgggcgc ttcctccgcg     420

ggtatgaaca gttcgcctac gacggcaagg attatctcac cctgaatgag gacctgcgct     480

cctggaccgc ggtggacacg gcggctcaga tctccgagca aaagtcaaat gatgcctctg     540

aggcggagca ccagagagcc tacctggaag acacatgcgt ggagtggctc cacaaatacc     600

tggagaaggg gaaggagacg ctgcttcacc tggagccccc aaagacacac gtgactcacc     660

accccatctc tgaccatgag gccaccctga ggtgctgggc cctgggcttc taccctgcgg     720

agatcacact gacctggcag caggatgggg agggccatac ccaggacacg gagctcgtgg     780

agaccaggcc tgcaggggat ggaaccttcc agaagtgggc agctgtggtg gtgccttctg     840

gagaggagca gagatacacg tgccatgtgc agcatgaggg gctacccgag cccgtcaccc     900

tgagatggaa gccggcttcc cagcccacca tccccatcgt gggcatcatt gctggcctgg     960

ttctccttgg atctgtggtc tctggagctg tggttgctgc tgtgatatgg aggaagaaga    1020

gctcaggtgg aaaaggaggg agctactcta aggctgagtg gagcgacagt gcccaggggt    1080

ctgagtctca cagcttgtaa agcctgagac agctgccttg tgtgcgactg agatgcacag    1140

ctgccttgtg tgcgactgag atgcaggatt tcctcacgcc tcccctatgt gtcttagggg    1200

actctggctt ctctttttgc aagggcctct gaatctgtct gtgtccctgt tagcacaatg    1260

tgaggaggta gagaaacagt ccacctctgt gtctaccatg acccccttcc tcacactgac    1320

ctgtgttcct tccctgttct cttttctatt aaaaataaga acctgggcag agtgcggcag    1380

ctcatgcctg taatcccagc acttagggag gccgaggagg gcagatcacg aggtcaggag    1440

atcgaaacca tcctggctaa cacggtgaaa ccccgtctct actaaaaaat acaaaaaatt    1500

agctgggcgc agaggcacgg gcctgtagtc ccagctactc aggaggcgga ggcaggagaa    1560

tggcgtcaac ccgggaggcg gaggttgcag tgagccagga ttgtgcgact gcactccagc    1620

ctgggtgaca gggtgaaacg ccatctcaaa aaataaaaat tgaaaaataa aaaaagaacc    1680

tggatctcaa tttaattttt catattcttg caatgaaatg gacttgagga agctaagatc    1740

atagctagaa atacagataa ttccacagca catctctagc aaatttagcc tattcctatt    1800

ctctagccta ttccttacca cctgtaatct tgaccatata ccttggagtt gaatattgtt    1860

ttcatactgc tgtggtttga atgttccctc caacactcat gttgagactt aatccctaat    1920

gtggcaatac tgaaaggtgg ggcctttgag atgtgattgg atcgtaaggc tgtgccttca    1980

ttcatgggtt aatggattaa tgggttatca caggaatggg actggtggct ttataagaag    2040

aggaaaagag aactgagcta gcatgcccag cccacagaga gcctccacta gagtgatgct    2100

aagtggaaat gtgaggtgca gctgccacag agggccccca ccagggaaat gtctagtgtc    2160

tagtggatcc aggccacagg agagagtgcc ttgtggagcg ctgggagcag gacctgacca    2220

ccaccaggac cccagaactg tggagtcagt ggcagcatgc agcgccccct tgggaaagct    2280

ttaggcacca gcctgcaacc cattcgagca gccacgtagg ctgcacccag caaagccaca    2340

ggcacggggc tacctgaggc cttgggggcc caatccctgc tccagtgtgt ccgtgaggca    2400

gcacacgaag tcaaaagaga ttattctctt cccacagata ccttttctct cccatgaccc    2460

tttaacagca tctgcttcat tcccctcacc ttcccaggct gatctgaggt aaactttgaa    2520

gtaaaataaa agctgtgttt gagcatca                                       2548


<210> 25
<211> 1480
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-F1

<400> 25
atatttttcc cagacgcgga ggttggggtc atggcgcccc gaagcctcct cctgctgctc      60

tcaggggccc tggccctgac cgatacttgg gcgggctccc actccttgag gtatttcagc     120

accgctgtgt cgcggcccgg ccgcggggag ccccgctaca tcgccgtgga gtacgtagac     180

gacacgcaat tcctgcggtt cgacagcgac gccgcgattc cgaggatgga gccgcgggag     240

ccgtgggtgg agcaagaggg gccgcagtat tgggagtgga ccacagggta cgccaaggcc     300

aacgcacaga ctgaccgagt ggccctgagg aacctgctcc gccgctacaa ccagagcgag     360

gctgggtctc acaccctcca gggaatgaat ggctgcgaca tggggcccga cggacgcctc     420

ctccgcgggt atcaccagca cgcgtacgac ggcaaggatt acatctccct gaacgaggac     480

ctgcgctcct ggaccgcggc ggacaccgtg gctcagatca cccagcgctt ctatgaggca     540

gaggaatatg cagaggagtt caggacctac ctggagggcg agtgcctgga gttgctccgc     600

agatacttgg agaatgggaa ggagacgcta cagcgcgcag atcctccaaa ggcacacgtt     660

gcccaccacc ccatctctga ccatgaggcc accctgaggt gctgggccct gggcttctac     720

cctgcggaga tcacgctgac ctggcagcgg gatggggagg aacagaccca ggacacagag     780

cttgtggaga ccaggcctgc aggggatgga accttccaga agtgggccgc tgtggtggtg     840

cctcctggag aggaacagag atacacatgc catgtgcagc acgaggggct gccccagccc     900

ctcatcctga gatgggagca gtctccccag cccaccatcc ccatcgtggg catcgttgct     960

ggccttgttg tccttggagc tgtggtcact ggagctgtgg tcgctgctgt gatgtggagg    1020

aagaagagct cagatagaaa cagagggagc tactctcagg ctgcagccta ctcagtggtc    1080

agcggaaact tgatgataac atggtggtca agcttatttc tcctgggggt gctcttccaa    1140

ggatatttgg gctgcctccg gagtcacagt gtcttgggcc gccggaaggt gggtgacatg    1200

tggatcttgt tttttttgtg gctgtggaca tctttcaaca ctgccttctt ggccttgcaa    1260

agccttcgct ttggcttcgg ctttaggagg ggcaggagct tccttcttcg ttcttggcac    1320

catcttatga aaagggtcca gattaagatt tttgactgag tcattctaaa gtaagttgca    1380

agacccatga tactagacca ctaaatactt catcacacac ctcctaagaa taagaaccaa    1440

cattatcaca ccaaagaaaa taaataattc cataatatta                          1480


<210> 26
<211> 1301
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-F2

<400> 26
tttctcactc ccattgggcg tcgcgtttct agagaagcca atcagtgtcg ccgcagttcc      60

caggttctaa agtcccacgc accccgcggg actcatattt ttcccagacg cggaggttgg     120

ggtcatggcg ccccgaagcc tcctcctgct gctctcaggg gccctggccc tgaccgatac     180

ttgggcgggc tcccactcct tgaggtattt cagcaccgct gtgtcgcggc ccggccgcgg     240

ggagccccgc tacatcgccg tggagtacgt agacgacacg caattcctgc ggttcgacag     300

cgacgccgcg attccgagga tggagccgcg ggagccgtgg gtggagcaag aggggccgca     360

gtattgggag tggaccacag ggtacgccaa ggccaacgca cagactgacc gagtggccct     420

gaggaacctg ctccgccgct acaaccagag cgaggctggg tctcacaccc tccagggaat     480

gaatggctgc gacatggggc ccgacggacg cctcctccgc gggtatcacc agcacgcgta     540

cgacggcaag gattacatct ccctgaacga ggacctgcgc tcctggaccg cggcggacac     600

cgtggctcag atcacccagc gcttctatga ggcagaggaa tatgcagagg agttcaggac     660

ctacctggag ggcgagtgcc tggagttgct ccgcagatac ttggagaatg ggaaggagac     720

gctacagcgc gcagatcctc caaaggcaca cgttgcccac caccccatct ctgaccatga     780

ggccaccctg aggtgctggg ccctgggctt ctaccctgcg gagatcacgc tgacctggca     840

gcgggatggg gaggaacaga cccaggacac agagcttgtg gagaccaggc ctgcagggga     900

tggaaccttc cagaagtggg ccgctgtggt ggtgcctcct ggagaggaac agagatacac     960

atgccatgtg cagcacgagg ggctgcccca gcccctcatc ctgagatggg agcagtctcc    1020

ccagcccacc atccccatcg tgggcatcgt tgctggcctt gttgtccttg gagctgtggt    1080

cactggagct gtggtcgctg ctgtgatgtg gaggaagaag agctcagata gaaacagagg    1140

gagctactct caggctgcag tgtgagacag cttccttgtg tgggactgag aagcaagata    1200

tcaatgtagc agaattgcac ttgtgcctca cgaacataca taaattttaa aaataaagaa    1260

taaaaatata tctttttata gataaaaaaa aaaaaaaaaa a                        1301


<210> 27
<211> 912
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-F3

<400> 27
atatttttcc cagacgcgga ggttggggtc atggcgcccc gaagcctcct cctgctgctc      60

tcaggggccc tggccctgac cgatacttgg gcgggctccc actccttgag gtatttcagc     120

accgctgtgt cgcggcccgg ccgcggggag ccccgctaca tcgccgtgga gtacgtagac     180

gacacgcaat tcctgcggtt cgacagcgac gccgcgattc cgaggatgga gccgcgggag     240

ccgtgggtgg agcaagaggg gccgcagtat tgggagtgga ccacagggta cgccaaggcc     300

aacgcacaga ctgaccgagt ggccctgagg aacctgctcc gccgctacaa ccagagcgag     360

gctgggtctc acaccctcca gggaatgaat ggctgcgaca tggggcccga cggacgcctc     420

ctccgcgggt atcaccagca cgcgtacgac ggcaaggatt acatctccct gaacgaggac     480

ctgcgctcct ggaccgcggc ggacaccgtg gctcagatca cccagcgctt ctatgaggca     540

gaggaatatg cagaggagtt caggacctac ctggagggcg agtgcctgga gttgctccgc     600

agatacttgg agaatgggaa ggagacgcta cagcgcgcag agcagtctcc ccagcccacc     660

atccccatcg tgggcatcgt tgctggcctt gttgtccttg gagctgtggt cactggagct     720

gtggtcgctg ctgtgatgtg gaggaagaag agctcagata gaaacagagg gagctactct     780

caggctgcag tgtgagacag cttccttgtg tgggactgag aagcaagata tcaatgtagc     840

agaattgcac ttgtgcctca cgaacataca taaattttaa aaataaagaa taaaaatata     900

tctttttata ga                                                         912


<210> 28
<211> 1578
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-G1

<400> 28
agtgtggtac tttgtcttga ggagatgtcc tggactcaca cggaaactta gggctacgga      60

atgaagttct cactcccatt aggtgacagg tttttagaga agccaatcag cgtcgccgcg     120

gtcctggttc taaagtcctc gctcacccac ccggactcat tctccccaga cgccaaggat     180

ggtggtcatg gcgccccgaa ccctcttcct gctgctctcg ggggccctga ccctgaccga     240

gacctgggcg ggctcccact ccatgaggta tttcagcgcc gccgtgtccc ggcccggccg     300

cggggagccc cgcttcatcg ccatgggcta cgtggacgac acgcagttcg tgcggttcga     360

cagcgactcg gcgtgtccga ggatggagcc gcgggcgccg tgggtggagc aggaggggcc     420

ggagtattgg gaagaggaga cacggaacac caaggcccac gcacagactg acagaatgaa     480

cctgcagacc ctgcgcggct actacaacca gagcgaggcc agttctcaca ccctccagtg     540

gatgattggc tgcgacctgg ggtccgacgg acgcctcctc cgcgggtatg aacagtatgc     600

ctacgatggc aaggattacc tcgccctgaa cgaggacctg cgctcctgga ccgcagcgga     660

cactgcggct cagatctcca agcgcaagtg tgaggcggcc aatgtggctg aacaaaggag     720

agcctacctg gagggcacgt gcgtggagtg gctccacaga tacctggaga acgggaagga     780

gatgctgcag cgcgcggacc cccccaagac acacgtgacc caccaccctg tctttgacta     840

tgaggccacc ctgaggtgct gggccctggg cttctaccct gcggagatca tactgacctg     900

gcagcgggat ggggaggacc agacccagga cgtggagctc gtggagacca ggcctgcagg     960

ggatggaacc ttccagaagt gggcagctgt ggtggtgcct tctggagagg agcagagata    1020

cacgtgccat gtgcagcatg aggggctgcc ggagcccctc atgctgagat ggaagcagtc    1080

ttccctgccc accatcccca tcatgggtat cgttgctggc ctggttgtcc ttgcagctgt    1140

agtcactgga gctgcggtcg ctgctgtgct gtggagaaag aagagctcag attgaaaagg    1200

agggagctac tctcaggctg caatgtgaaa cagctgccct gtgtgggact gagtggcaag    1260

tccctttgtg acttcaagaa ccctgactcc tctttgtgca gagaccagcc cacccctgtg    1320

cccaccatga ccctcttcct catgctgaac tgcattcctt ccccaatcac ctttcctgtt    1380

ccagaaaagg ggctgggatg tctccgtctc tgtctcaaat ttgtggtcca ctgagctata    1440

acttacttct gtattaaaat tagaatctga gtataaattt actttttcaa attatttcca    1500

agagagattg atgggttaat taaaggagaa gattcctgaa atttgagaga caaaataaat    1560

ggaagacatg agaacttt                                                  1578


<210> 29
<211> 1302
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-G2

<400> 29
agtgtggtac tttgtcttga ggagatgtcc tggactcaca cggaaactta gggctacgga      60

atgaagttct cactcccatt aggtgacagg tttttagaga agccaatcag cgtcgccgcg     120

gtcctggttc taaagtcctc gctcacccac ccggactcat tctccccaga cgccaaggat     180

ggtggtcatg gcgccccgaa ccctcttcct gctgctctcg ggggccctga ccctgaccga     240

gacctgggcg ggctcccact ccatgaggta tttcagcgcc gccgtgtccc ggcccggccg     300

cggggagccc cgcttcatcg ccatgggcta cgtggacgac acgcagttcg tgcggttcga     360

cagcgactcg gcgtgtccga ggatggagcc gcgggcgccg tgggtggagc aggaggggcc     420

ggagtattgg gaagaggaga cacggaacac caaggcccac gcacagactg acagaatgaa     480

cctgcagacc ctgcgcggct actacaacca gagcgaggcc aaccccccca agacacacgt     540

gacccaccac cctgtctttg actatgaggc caccctgagg tgctgggccc tgggcttcta     600

ccctgcggag atcatactga cctggcagcg ggatggggag gaccagaccc aggacgtgga     660

gctcgtggag accaggcctg caggggatgg aaccttccag aagtgggcag ctgtggtggt     720

gccttctgga gaggagcaga gatacacgtg ccatgtgcag catgaggggc tgccggagcc     780

cctcatgctg agatggaagc agtcttccct gcccaccatc cccatcatgg gtatcgttgc     840

tggcctggtt gtccttgcag ctgtagtcac tggagctgcg gtcgctgctg tgctgtggag     900

aaagaagagc tcagattgaa aaggagggag ctactctcag gctgcaatgt gaaacagctg     960

ccctgtgtgg gactgagtgg caagtccctt tgtgacttca agaaccctga ctcctctttg    1020

tgcagagacc agcccacccc tgtgcccacc atgaccctct tcctcatgct gaactgcatt    1080

ccttccccaa tcacctttcc tgttccagaa aaggggctgg gatgtctccg tctctgtctc    1140

aaatttgtgg tccactgagc tataacttac ttctgtatta aaattagaat ctgagtataa    1200

atttactttt tcaaattatt tccaagagag attgatgggt taattaaagg agaagattcc    1260

tgaaatttga gagacaaaat aaatggaaga catgagaact tt                       1302


<210> 30
<211> 1026
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-G3

<400> 30
agtgtggtac tttgtcttga ggagatgtcc tggactcaca cggaaactta gggctacgga      60

atgaagttct cactcccatt aggtgacagg tttttagaga agccaatcag cgtcgccgcg     120

gtcctggttc taaagtcctc gctcacccac ccggactcat tctccccaga cgccaaggat     180

ggtggtcatg gcgccccgaa ccctcttcct gctgctctcg ggggccctga ccctgaccga     240

gacctgggcg ggctcccact ccatgaggta tttcagcgcc gccgtgtccc ggcccggccg     300

cggggagccc cgcttcatcg ccatgggcta cgtggacgac acgcagttcg tgcggttcga     360

cagcgactcg gcgtgtccga ggatggagcc gcgggcgccg tgggtggagc aggaggggcc     420

ggagtattgg gaagaggaga cacggaacac caaggcccac gcacagactg acagaatgaa     480

cctgcagacc ctgcgcggct actacaacca gagcgaggcc aagcagtctt ccctgcccac     540

catccccatc atgggtatcg ttgctggcct ggttgtcctt gcagctgtag tcactggagc     600

tgcggtcgct gctgtgctgt ggagaaagaa gagctcagat tgaaaaggag ggagctactc     660

tcaggctgca atgtgaaaca gctgccctgt gtgggactga gtggcaagtc cctttgtgac     720

ttcaagaacc ctgactcctc tttgtgcaga gaccagccca cccctgtgcc caccatgacc     780

ctcttcctca tgctgaactg cattccttcc ccaatcacct ttcctgttcc agaaaagggg     840

ctgggatgtc tccgtctctg tctcaaattt gtggtccact gagctataac ttacttctgt     900

attaaaatta gaatctgagt ataaatttac tttttcaaat tatttccaag agagattgat     960

gggttaatta aaggagaaga ttcctgaaat ttgagagaca aaataaatgg aagacatgag    1020

aacttt                                                               1026


<210> 31
<211> 1302
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-G4

<400> 31
agtgtggtac tttgtcttga ggagatgtcc tggactcaca cggaaactta gggctacgga      60

atgaagttct cactcccatt aggtgacagg tttttagaga agccaatcag cgtcgccgcg     120

gtcctggttc taaagtcctc gctcacccac ccggactcat tctccccaga cgccaaggat     180

ggtggtcatg gcgccccgaa ccctcttcct gctgctctcg ggggccctga ccctgaccga     240

gacctgggcg ggctcccact ccatgaggta tttcagcgcc gccgtgtccc ggcccggccg     300

cggggagccc cgcttcatcg ccatgggcta cgtggacgac acgcagttcg tgcggttcga     360

cagcgactcg gcgtgtccga ggatggagcc gcgggcgccg tgggtggagc aggaggggcc     420

ggagtattgg gaagaggaga cacggaacac caaggcccac gcacagactg acagaatgaa     480

cctgcagacc ctgcgcggct actacaacca gagcgaggcc agttctcaca ccctccagtg     540

gatgattggc tgcgacctgg ggtccgacgg acgcctcctc cgcgggtatg aacagtatgc     600

ctacgatggc aaggattacc tcgccctgaa cgaggacctg cgctcctgga ccgcagcgga     660

cactgcggct cagatctcca agcgcaagtg tgaggcggcc aatgtggctg aacaaaggag     720

agcctacctg gagggcacgt gcgtggagtg gctccacaga tacctggaga acgggaagga     780

gatgctgcag cgcgcggagc agtcttccct gcccaccatc cccatcatgg gtatcgttgc     840

tggcctggtt gtccttgcag ctgtagtcac tggagctgcg gtcgctgctg tgctgtggag     900

aaagaagagc tcagattgaa aaggagggag ctactctcag gctgcaatgt gaaacagctg     960

ccctgtgtgg gactgagtgg caagtccctt tgtgacttca agaaccctga ctcctctttg    1020

tgcagagacc agcccacccc tgtgcccacc atgaccctct tcctcatgct gaactgcatt    1080

ccttccccaa tcacctttcc tgttccagaa aaggggctgg gatgtctccg tctctgtctc    1140

aaatttgtgg tccactgagc tataacttac ttctgtatta aaattagaat ctgagtataa    1200

atttactttt tcaaattatt tccaagagag attgatgggt taattaaagg agaagattcc    1260

tgaaatttga gagacaaaat aaatggaaga catgagaact tt                       1302


<210> 32
<211> 1138
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-G5

<400> 32
agtgtggtac tttgtcttga ggagatgtcc tggactcaca cggaaactta gggctacgga      60

atgaagttct cactcccatt aggtgacagg tttttagaga agccaatcag cgtcgccgcg     120

gtcctggttc taaagtcctc gctcacccac ccggactcat tctccccaga cgccaaggat     180

ggtggtcatg gcgccccgaa ccctcttcct gctgctctcg ggggccctga ccctgaccga     240

gacctgggcg ggctcccact ccatgaggta tttcagcgcc gccgtgtccc ggcccggccg     300

cggggagccc cgcttcatcg ccatgggcta cgtggacgac acgcagttcg tgcggttcga     360

cagcgactcg gcgtgtccga ggatggagcc gcgggcgccg tgggtggagc aggaggggcc     420

ggagtattgg gaagaggaga cacggaacac caaggcccac gcacagactg acagaatgaa     480

cctgcagacc ctgcgcggct actacaacca gagcgaggcc agttctcaca ccctccagtg     540

gatgattggc tgcgacctgg ggtccgacgg acgcctcctc cgcgggtatg aacagtatgc     600

ctacgatggc aaggattacc tcgccctgaa cgaggacctg cgctcctgga ccgcagcgga     660

cactgcggct cagatctcca agcgcaagtg tgaggcggcc aatgtggctg aacaaaggag     720

agcctacctg gagggcacgt gcgtggagtg gctccacaga tacctggaga acgggaagga     780

gatgctgcag cgcgcggacc cccccaagac acacgtgacc caccaccctg tctttgacta     840

tgaggccacc ctgaggtgct gggccctggg cttctaccct gcggagatca tactgacctg     900

gcagcgggat ggggaggacc agacccagga cgtggagctc gtggagacca ggcctgcagg     960

ggatggaacc ttccagaagt gggcagctgt ggtggtgcct tctggagagg agcagagata    1020

cacgtgccat gtgcagcatg aggggctgcc ggagcccctc atgctgagat ggagtaagga    1080

gggagatgga ggcatcatgt ctgttaggga aagcaggagc ctctctgaag acctttaa      1138


<210> 33
<211> 862
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-G6

<400> 33
agtgtggtac tttgtcttga ggagatgtcc tggactcaca cggaaactta gggctacgga      60

atgaagttct cactcccatt aggtgacagg tttttagaga agccaatcag cgtcgccgcg     120

gtcctggttc taaagtcctc gctcacccac ccggactcat tctccccaga cgccaaggat     180

ggtggtcatg gcgccccgaa ccctcttcct gctgctctcg ggggccctga ccctgaccga     240

gacctgggcg ggctcccact ccatgaggta tttcagcgcc gccgtgtccc ggcccggccg     300

cggggagccc cgcttcatcg ccatgggcta cgtggacgac acgcagttcg tgcggttcga     360

cagcgactcg gcgtgtccga ggatggagcc gcgggcgccg tgggtggagc aggaggggcc     420

ggagtattgg gaagaggaga cacggaacac caaggcccac gcacagactg acagaatgaa     480

cctgcagacc ctgcgcggct actacaacca gagcgaggcc aaccccccca agacacacgt     540

gacccaccac cctgtctttg actatgaggc caccctgagg tgctgggccc tgggcttcta     600

ccctgcggag atcatactga cctggcagcg ggatggggag gaccagaccc aggacgtgga     660

gctcgtggag accaggcctg caggggatgg aaccttccag aagtgggcag ctgtggtggt     720

gccttctgga gaggagcaga gatacacgtg ccatgtgcag catgaggggc tgccggagcc     780

cctcatgctg agatggagta aggagggaga tggaggcatc atgtctgtta gggaaagcag     840

gagcctctct gaagaccttt aa                                              862


<210> 34
<211> 529
<212> DNA
<213> Homo sapiens

<220> 
<223> HLA-G7

<400> 34
agtgtggtac tttgtcttga ggagatgtcc tggactcaca cggaaactta gggctacgga      60

atgaagttct cactcccatt aggtgacagg tttttagaga agccaatcag cgtcgccgcg     120

gtcctggttc taaagtcctc gctcacccac ccggactcat tctccccaga cgccaaggat     180

ggtggtcatg gcgccccgaa ccctcttcct gctgctctcg ggggccctga ccctgaccga     240

gacctgggcg ggctcccact ccatgaggta tttcagcgcc gccgtgtccc ggcccggccg     300

cggggagccc cgcttcatcg ccatgggcta cgtggacgac acgcagttcg tgcggttcga     360

cagcgactcg gcgtgtccga ggatggagcc gcgggcgccg tgggtggagc aggaggggcc     420

ggagtattgg gaagaggaga cacggaacac caaggcccac gcacagactg acagaatgaa     480

cctgcagacc ctgcgcggct actacaacca gagcgaggcc agtgagtaa                 529


<210> 35
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> redox-active site

<400> 35
Cys Gly Pro Cys 
1               

<210> 36
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex3 Forward Primer

<400> 36
ggccggagta ttgggaaga                                                 19


<210> 37
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex3 Probe

<400> 37
caaggcccac gcacagactg aca                                            23


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex3 Reverse Primer

<400> 38
gcagggtctg caggttcatt                                                20


<210> 39
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex4 Forward Primer

<400> 39
ctgcggctca gatctccaa                                                 19


<210> 40
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex4 Probe

<400> 40
cgcaagtgtg aggcggccaa t                                              21


<210> 41
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex4 Reverse Primer

<400> 41
caggtaggct ctcctttgtt cag                                            23


<210> 42
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex5 Forward Primer

<400> 42
caccaccctg tctttgacta tgag                                           24


<210> 43
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex5 Probe

<400> 43
accctgaggt gctgggccct g                                              21


<210> 44
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex5 Reverse Primer

<400> 44
agtatgatct ccgcagggta gaag                                           24


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex6 Forward Primer

<400> 45
catccccatc atgggtatcg                                                20


<210> 46
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex6 Probe

<400> 46
tgctggcctg gttgtccttg ca                                             22


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex6 Reverse Primer

<400> 47
ccgcagctcc agtgactaca                                                20


<210> 48
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex8 Forward Primer

<400> 48
gaccctcttc ctcatgctga ac                                             22


<210> 49
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex8 Probe

<400> 49
cattccttcc ccaatcacct ttcctgtt                                       28


<210> 50
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex8 Reverse Primer

<400> 50
catcccagcc ccttttctg                                                 19


<210> 51
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex3-5 Forward Primer

<400> 51
ttcatcgcca tgggctacg                                                 19


<210> 52
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex3-5 Probe

<400> 52
cgacacgcag ttcgtgcggt tc                                             22


<210> 53
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex3-5 Reverse Primer

<400> 53
atcctcggac acgccgagt                                                 19


<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex2/3 Forward Primer

<400> 54
ccgaaccctc ttcctgctgc                                                20


<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex2/3 Probe

<400> 55
cgagacctgg gcgggctccc                                                20


<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-G Ex2/3 Reverse Primer

<400> 56
gcgctgaaat acctcatgga                                                20


<210> 57
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-H Ex2/3 Forward Primer

<400> 57
gagagaacct gcggatcgc                                                 19


<210> 58
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-H Ex2/3 Probe

<400> 58
agcgagggcg gttctcacac catg                                           24


<210> 59
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-H Ex2/3 Reverse Primer

<400> 59
ccacgtcgca gccatacat                                                 19


<210> 60
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-H Forward Primer

<400> 60
gagagaacct gcggatcgc                                                 19


<210> 61
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-H Probe

<400> 61
accagagcga gggcggttct cacac                                          25


<210> 62
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-H Reverse Primer

<400> 62
cgggccggga catggt                                                    16


<210> 63
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> KRT5 Forward Primer

<400> 63
cgccacttac cgcaagct                                                  18


<210> 64
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> KRT5 Probe

<400> 64
tggagggcga ggaatgcaga ctca                                           24


<210> 65
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> KRT5 Reverse Primer

<400> 65
acagagatgt tgactggtcc aactc                                          25


<210> 66
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> KRT20 Forward Primer

<400> 66
gcgactacag tgcatattac agacaa                                         26


<210> 67
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> KRT20 Probe

<400> 67
ttgaagagct gcgaagtcag attaaggatg ct                                   32


<210> 68
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> KRT20 Reverse Primer

<400> 68
cacaccgagc attttgcagt t                                              21


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALM2 Forward Primer

<400> 69
gagcgagctg agtggttgtg                                                20


<210> 70
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALM2 Probe

<400> 70
tcgcgtctcg gaaaccggta gc                                             22


<210> 71
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALM2 Reverse Primer

<400> 71
agtcagttgg tcagccatgc t                                              21


<210> 72
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-L Ex2/3 Forward Primer

<400> 72
cctgctccgc tattacaacc a                                              21


<210> 73
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-L Ex2/3 Probe

<400> 73
cgaggccggt atgaacagtt cgccta                                         26


<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-L Ex2/3 Reverse Primer

<400> 74
cgttcagggc gatgtaatcc                                                20


<210> 75
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-L Ex5/6 Forward Primer

<400> 75
gctgtggttg ctgctgcg                                                  18


<210> 76
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-L Ex5/6 Probe

<400> 76
agaaaagctc aggcagcaat tgtgctcag                                      29


<210> 77
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-L Ex5/6 Reverse Primer

<400> 77
catagtcctc tttacaagta tcatgagatg                                     30


<210> 78
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-L Ex7 Forward Primer

<400> 78
tcctcttctg ctcagctctc cta                                            23


<210> 79
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-L Ex7 Probe

<400> 79
ctctcccttc cctgagttgt agtaatccta gcact                                35


<210> 80
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-L Ex7 Reverse Primer

<400> 80
gctttataga tccatgagtt tgcatta                                        27


<210> 81
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-J Ex4/5 Forward Primer

<400> 81
caaggggctg cccaagc                                                   17


<210> 82
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-J Ex4/5 Probe

<400> 82
catcctgaga tgggtcacac atttctggaa                                     30


<210> 83
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> HLA-J Ex4/5 Reverse Primer

<400> 83
cctcctagtc ttggaacctt gagaagt                                        27


