                         SEQUENCE LISTING

<110>  University of Manitoba
       Yao, Xiao-Jian
 
<120>  DENDRITIC CELL-TARGETING UNIVERSAL VACCINE FOR INFLUENZA 
       INFECTION

<130>  82402-307PCT

<150>  US62/923842
<151>  2019-10-21

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  281
<212>  PRT
<213>  artificial

<220>
<223>  artificial fusion peptide comprising head COBRA H5/H1/H3 regions


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (6)..(66)
<223>  H5 head COBRA sequence

<220>
<221>  MISC_FEATURE
<222>  (67)..(71)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (72)..(111)
<223>  head COBRA H1 sequence

<220>
<221>  MISC_FEATURE
<222>  (112)..(116)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (117)..(132)
<223>  head COBRA H1 sequence

<220>
<221>  MISC_FEATURE
<222>  (119)..(183)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (133)..(137)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (138)..(178)
<223>  head COBRA H1 sequence

<220>
<221>  MISC_FEATURE
<222>  (184)..(276)
<223>  head COBRA H3 sequence

<220>
<221>  MISC_FEATURE
<222>  (277)..(281)
<223>  spacer

<400>  1

Gly Pro Gly Pro Gly Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu 
1               5                   10                  15      


Asp Gly Val Lys Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp 
            20                  25                  30          


Leu Leu Gly Asn Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp 
        35                  40                  45              


Ser Tyr Ile Val Glu Lys Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro 
    50                  55                  60                  


Gly Asn Gly Pro Gly Pro Gly Cys Tyr Pro Gly Tyr Phe Ala Asp Tyr 
65                  70                  75                  80  


Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe 
                85                  90                  95      


Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Thr Val Thr Gly 
            100                 105                 110         


Pro Gly Pro Gly Glu Lys Glu Val Leu Val Leu Trp Gly Val His His 
        115                 120                 125             


Pro Ser Asn Ile Gly Pro Gly Pro Gly Pro Lys Val Arg Asp Gln Glu 
    130                 135                 140                 


Gly Arg Ile Asn Tyr Tyr Trp Thr Leu Leu Glu Pro Gly Asp Thr Ile 
145                 150                 155                 160 


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Trp Tyr Ala Phe Ala 
                165                 170                 175     


Leu Ser Gly Pro Gly Pro Gly Asn Asn Glu Lys Phe Asp Lys Leu Tyr 
            180                 185                 190         


Ile Trp Gly Val His His Pro Gly Thr Asp Ser Asp Gln Ile Ser Leu 
        195                 200                 205             


Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg Ser Gln 
    210                 215                 220                 


Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Val Arg Asp Val 
225                 230                 235                 240 


Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile 
                245                 250                 255     


Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe 
            260                 265                 270         


Lys Ile Arg Ser Gly Pro Gly Pro Gly 
        275                 280     


<210>  2
<211>  194
<212>  PRT
<213>  artificial

<220>
<223>  artificial fusion peptide of HA stalk region and M2eh region


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (31)..(33)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (71)..(73)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (93)..(95)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (192)..(194)
<223>  spacer

<400>  2

Gly Pro Gly Pro Ser Ala Glu Gln Val Asp Thr Ile Met Glu Lys Asn 
1               5                   10                  15      


Val Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Thr His Gly Ser 
            20                  25                  30          


Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile His Pro Leu Thr Ile 
        35                  40                  45              


Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Arg Leu Val Leu Ala Thr 
    50                  55                  60                  


Gly Leu Arg Asn Ser Pro Gly Ser Ala Ser Leu Leu Thr Glu Val Glu 
65                  70                  75                  80  


Thr Pro Ile Arg Asn Glu Trp Gly Cys Arg Cys Asn Gly Ser Ala Ser 
                85                  90                  95      


Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile 
            100                 105                 110         


Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn 
        115                 120                 125             


Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe 
    130                 135                 140                 


Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn 
145                 150                 155                 160 


Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp 
                165                 170                 175     


Lys Val Arg Arg Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly 
            180                 185                 190         


Ser Ala 
        


<210>  3
<211>  111
<212>  PRT
<213>  artificial

<220>
<223>  fusion protein comprising M2e regions


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (27)..(30)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (54)..(57)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (81)..(84)
<223>  spacer

<220>
<221>  MISC_FEATURE
<222>  (108)..(111)
<223>  spacer

<400>  3

Gly Gly Ser Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu 
1               5                   10                  15      


Trp Gly Cys Arg Cys Asn Asp Ser Ser Asp Gly Gly Gly Ser Ser Leu 
            20                  25                  30          


Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Gly Trp Glu Cys Lys Cys 
        35                  40                  45              


Ser Asp Ser Ser Asp Gly Gly Gly Ser Ser Leu Leu Thr Glu Val Glu 
    50                  55                  60                  


Thr Pro Ile Arg Asn Glu Trp Gly Cys Arg Cys Asn Asp Ser Ser Asp 
65                  70                  75                  80  


Gly Gly Gly Ser Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn 
                85                  90                  95      


Gly Trp Glu Cys Arg Cys Asn Asp Ser Ser Asp Gly Gly Gly Ser 
            100                 105                 110     


