                         SEQUENCE LISTING

<110>  Macquarie University
 
<120>  Modulation of cellular viability

<130>  35548307

<150>  AU 2019903956
<151>  2019-10-21

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  4287
<212>  DNA
<213>  Homo sapiens

<400>  1
ctgcgcctgc gcgagggcta cgcgcgctcc ggccggggcg cgggcgcgct ctcaggcggg       60

ctccggcggc agcgacgcga gcgcggcgat ggggagcggc ggcgtggtcc actgtaggtg      120

tgccaagtgt ttctgttatc ctacaaagcg aagaataagg aggaggcccc gaaacctgac      180

catcttgagt ctccccgaag atgtgctctt tcacatcctg aaatggcttt ctgtagagga      240

catcctggcc gtccgagctg tacactccca gctgaaggac ctggtggaca accacgccag      300

tgtgtgggca tgtgccagct tccaggagct gtggccgtct ccagggaacc tgaagctctt      360

tgaaagggct gctgaaaagg ggaatttcga agctgctgtg aagctgggca tagcctacct      420

ctacaatgaa ggcctgtctg tgtctgatga ggcccgcgca gaagtgaatg gcctgaaggc      480

ctctcgcttc ttcagtctcg ctgagcggct gaatgtgggt gccgcacctt tcatctggct      540

cttcatccgc cctccgtggt cggtgagcgg aagctgctgc aaggccgtgg ttcacgagag      600

cctcagggca gagtgccagc tgcagaggac tcacaaagca tccatattgc actgcttggg      660

cagagtgctg agtctgttcg aggatgagga gaagcagcag caggcccatg acctgtttga      720

ggaggctgct catcagggat gtctgaccag ctcctacctc ctctgggaaa gcgacaggag      780

gacagatgtg tcagatcctg ggcgatgcct ccacagcttc cgaaaactca gggactacgc      840

tgccaaaggc tgctgggaag cgcagctgtc tttagccaaa gcctgtgcaa atgcaaacca      900

gcttggactg gaggtgagag cttccagtga gatcgtctgc cagctatttc aggcttccca      960

ggctgtcagt aaacaacaag tcttctccgt gcagaaggga ctcaatgaca caatgaggta     1020

cattctgatc gactggctgg tggaagttgc caccatgaag gacttcacaa gcctgtgcct     1080

gcacctgacc gtggagtgtg tggaccggta cctgcggagg aggctggtgc cgcggtacag     1140

gctccagctg ctgggcatcg cctgcatggt catctgcacc cggtttatca gtaaagagat     1200

cctgaccatc cgggaggccg tatggctcac ggacaacact tacaagtacg aggacctggt     1260

gagaatgatg ggcgagatcg tctccgcctt ggaagggaag attcgagtcc ccactgtggt     1320

ggattacaag gaggtcctgc tgacgctagt ccctgtggag ctgagaaccc agcacctgtg     1380

cagcttcctc tgcgagctct ccctgctgca caccagcctg tccgcctacg ccccagcccg     1440

cctggctgcc gcagccctgc tcctggccag actgacgcac gggcagacac agccctggac     1500

cactcagctg tgggacctca ccggattctc ctatgaagac ctcattccct gcgtcttgag     1560

cctccataag aagtgcttcc atgatgacgc ccccaaggac tacaggcaag tctctctgac     1620

cgccgtgaag cagcggtttg aggacaagcg ctatggagaa atcagccagg aagaggtgct     1680

gagctacagc cagttgtgtg ctgcattagg agtgacacaa gacagccccg accccccgac     1740

tttcctcagc acaggggaga tccacgcctt cctcagctct ccctcggggc ggagaaccaa     1800

acggaagcgg gagaacagcc tccaggaaga cagaggcagc ttcgttacca cccccactgc     1860

ggagctgtcc agccaggagg agacgctgct gggcagcttc ctcgactgga gcctggactg     1920

ctgctctggc tatgaaggcg accaggagag tgagggcgag aaggagggcg acgtgacagc     1980

tcccagcggc atcctcgatg tcaccgtggt ctacctgaac ccagaacagc attgctgcca     2040

ggaatccagt gatgaggagg cttgtccaga ggacaaggga ccccaggacc cacaggcact     2100

ggcgctggac acccagatcc ctgcaacccc tggacccaaa cccctggtcc gcaccagccg     2160

ggagccaggg aaggacgtca cgacctcagg gtactcctcc gtcagcaccg caagtcccac     2220

aagctccgtg gacggtggct tgggggccct gccccaacct acctcagtgc tgtccctgga     2280

cagtgactcg cacacacagc cctgccacca tcaggccagg aagtcatgtt tacagtgtcg     2340

tcccccaagt cccccggaga gcagtgttcc ccagcaacag gtgaagcgga taaacctatg     2400

catacacagt gaggaggagg acatgaacct gggccttgtg aggctgtaag tgtgtcagca     2460

catttgccgc agtggatgtg tactgagggg gctggaggcg aagggtggga gcatagcata     2520

ggaacgctgc atagaccatg gaggcctttg cgcagagagc agagaggatg acttgcggcc     2580

accaagtttc tgtctccgcg ggagtcccgt gcaagccatc agaatgttga aatgagggtg     2640

aagagctcag atccctctct ttggaaagtt tagcctggaa gcagttggcc acactgtgtg     2700

gagggcacct ctctgtccct tccgtgtctc actgtctctg gaagcttcag cccatgtgtg     2760

tcctggtgtt cccagcccca ccagagcccc gtgccgggag ctgacagctt tcacgcttaa     2820

ggcacgtgtg acctgggtag tcagacacca cttgagcccc tgcccacatc tgctggtttg     2880

gggcttcagt ggggagctga cagctgtgag cacaccactg tcccctcatc cacctcggcc     2940

tgcatggggc acccacttcc ttctgggtgg ggcttccatg gtaagggggc ctgcgtccct     3000

gcacactgcg aggactgcct tggccacagg cccactccct acgacacgtg actcgtttta     3060

gagctctgtc ccagaggcgt tcgtatgtga cccacagatg gcgtcaatgt gaacacctct     3120

ctttgtgctg aatttctggg ccattctttt cctgtcttat ttctaaattt ccttcttcca     3180

agatgaaaac aaaagaaaaa cttaaaacag aaggtattaa aaaaacaaga gattcccacc     3240

attatttagg ttcacctgca aaacaaaaat cttactccag cccctcaatg ccatcctgac     3300

acactttatg caaaaagaat tttcccagat aggctagcca gaaaaaactt caagtcctct     3360

gtaacatctg aggtgaccaa gaggcagaag agcagagcag tcgggggccg tgtcctggct     3420

gatcccaact gcagctctgc tgtgggggcc cgtgggaggg aggcagaccc ctgggctttc     3480

ctgctggcca cggagactct gctcctgcat ggaaagggag cctgggagcc agcagcccac     3540

gcctggggag cctgcctggg gccatgtgac catggcctct ccctgggaac gggctgacca     3600

caacacaccc tgctgccatc cacttctgtt tactctgcaa atgtaagaaa gaaccacttg     3660

gccagaagtg tcccccagat gctttttttt tttttttttt ggagacagtt ttgctcttgt     3720

ctccccggct ggagtgcagt ggcatgatct caactctcaa ctcactgtaa cctccgcctc     3780

ccggatactc ctgcctcagc ctcctgggta gctgggatta caagcaccca accacgccca     3840

gctaattttt gtattttcgg tagagacggg atttcaccat gttggccagg ctagtctcga     3900

actcatgacc tcaagtgatc cgcccacttc ggtctcccaa agtgctggga ttacaggcat     3960

gagccacggc gcctggcccc caaatgctct tgaaccggaa acccagggat gggagatgct     4020

cactgagctg ctgcttttat gtgtgctggt gctatgtgtg ttcatgtccg cggcagctgt     4080

ctttttgcta ctataaggga attctggcca ccctgggtgg ggtgtggtcg gggtgagaac     4140

ccaagcgttg gaactgtaga cccgtcctgt cgactgtgtg cccctgggca tgtgtgagcc     4200

tcagtttcct catctgtaag gggggcaatg atacctacct cacaggggtg ttgtgaggat     4260

taaatgtgag gaggatagtg gcagatg                                         4287


<210>  2
<211>  2361
<212>  DNA
<213>  Homo sapiens

<400>  2
atggggagcg gcggcgtggt ccactgtagg tgtgccaagt gtttctgtta tcctacaaag       60

cgaagaataa ggaggaggcc ccgaaacctg accatcttga gtctccccga agatgtgctc      120

tttcacatcc tgaaatggct ttctgtagag gacatcctgg ccgtccgagc tgtacactcc      180

cagctgaagg acctggtgga caaccacgcc agtgtgtggg catgtgccag cttccaggag      240

ctgtggccgt ctccagggaa cctgaagctc tttgaaaggg ctgctgaaaa ggggaatttc      300

gaagctgctg tgaagctggg catagcctac ctctacaatg aaggcctgtc tgtgtctgat      360

gaggcccgcg cagaagtgaa tggcctgaag gcctctcgct tcttcagtct cgctgagcgg      420

ctgaatgtgg gtgccgcacc tttcatctgg ctcttcatcc gccctccgtg gtcggtgagc      480

ggaagctgct gcaaggccgt ggttcacgag agcctcaggg cagagtgcca gctgcagagg      540

actcacaaag catccatatt gcactgcttg ggcagagtgc tgagtctgtt cgaggatgag      600

gagaagcagc agcaggccca tgacctgttt gaggaggctg ctcatcaggg atgtctgacc      660

agctcctacc tcctctggga aagcgacagg aggacagatg tgtcagatcc tgggcgatgc      720

ctccacagct tccgaaaact cagggactac gctgccaaag gctgctggga agcgcagctg      780

tctttagcca aagcctgtgc aaatgcaaac cagcttggac tggaggtgag agcttccagt      840

gagatcgtct gccagctatt tcaggcttcc caggctgtca gtaaacaaca agtcttctcc      900

gtgcagaagg gactcaatga cacaatgagg tacattctga tcgactggct ggtggaagtt      960

gccaccatga aggacttcac aagcctgtgc ctgcacctga ccgtggagtg tgtggaccgg     1020

tacctgcgga ggaggctggt gccgcggtac aggctccagc tgctgggcat cgcctgcatg     1080

gtcatctgca cccggtttat cagtaaagag atcctgacca tccgggaggc cgtatggctc     1140

acggacaaca cttacaagta cgaggacctg gtgagaatga tgggcgagat cgtctccgcc     1200

ttggaaggga agattcgagt ccccactgtg gtggattaca aggaggtcct gctgacgcta     1260

gtccctgtgg agctgagaac ccagcacctg tgcagcttcc tctgcgagct ctccctgctg     1320

cacaccagcc tgtccgccta cgccccagcc cgcctggctg ccgcagccct gctcctggcc     1380

agactgacgc acgggcagac acagccctgg accactcagc tgtgggacct caccggattc     1440

tcctatgaag acctcattcc ctgcgtcttg agcctccata agaagtgctt ccatgatgac     1500

gcccccaagg actacaggca agtctctctg accgccgtga agcagcggtt tgaggacaag     1560

cgctatggag aaatcagcca ggaagaggtg ctgagctaca gccagttgtg tgctgcatta     1620

ggagtgacac aagacagccc cgaccccccg actttcctca gcacagggga gatccacgcc     1680

ttcctcagct ctccctcggg gcggagaacc aaacggaagc gggagaacag cctccaggaa     1740

gacagaggca gcttcgttac cacccccact gcggagctgt ccagccagga ggagacgctg     1800

ctgggcagct tcctcgactg gagcctggac tgctgctctg gctatgaagg cgaccaggag     1860

agtgagggcg agaaggaggg cgacgtgaca gctcccagcg gcatcctcga tgtcaccgtg     1920

gtctacctga acccagaaca gcattgctgc caggaatcca gtgatgagga ggcttgtcca     1980

gaggacaagg gaccccagga cccacaggca ctggcgctgg acacccagat ccctgcaacc     2040

cctggaccca aacccctggt ccgcaccagc cgggagccag ggaaggacgt cacgacctca     2100

gggtactcct ccgtcagcac cgcaagtccc acaagctccg tggacggtgg cttgggggcc     2160

ctgccccaac ctacctcagt gctgtccctg gacagtgact cgcacacaca gccctgccac     2220

catcaggcca ggaagtcatg tttacagtgt cgtcccccaa gtcccccgga gagcagtgtt     2280

ccccagcaac aggtgaagcg gataaaccta tgcatacaca gtgaggagga ggacatgaac     2340

ctgggccttg tgaggctgta a                                               2361


<210>  3
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Ser Gly Gly Val Val His Cys Arg Cys Ala Lys Cys Phe Cys 
1               5                   10                  15      


Tyr Pro Thr Lys Arg Arg Ile Arg Arg Arg Pro Arg Asn Leu Thr Ile 
            20                  25                  30          


Leu Ser Leu Pro Glu Asp Val Leu Phe His Ile Leu Lys Trp Leu Ser 
        35                  40                  45              


Val Glu Asp Ile Leu Ala Val Arg Ala Val His Ser Gln Leu Lys Asp 
    50                  55                  60                  


Leu Val Asp Asn His Ala Ser Val Trp Ala Cys Ala Ser Phe Gln Glu 
65                  70                  75                  80  


Leu Trp Pro Ser Pro Gly Asn Leu Lys Leu Phe Glu Arg Ala Ala Glu 
                85                  90                  95      


Lys Gly Asn Phe Glu Ala Ala Val Lys Leu Gly Ile Ala Tyr Leu Tyr 
            100                 105                 110         


Asn Glu Gly Leu Ser Val Ser Asp Glu Ala Arg Ala Glu Val Asn Gly 
        115                 120                 125             


Leu Lys Ala Ser Arg Phe Phe Ser Leu Ala Glu Arg Leu Asn Val Gly 
    130                 135                 140                 


Ala Ala Pro Phe Ile Trp Leu Phe Ile Arg Pro Pro Trp Ser Val Ser 
145                 150                 155                 160 


Gly Ser Cys Cys Lys Ala Val Val His Glu Ser Leu Arg Ala Glu Cys 
                165                 170                 175     


Gln Leu Gln Arg Thr His Lys Ala Ser Ile Leu His Cys Leu Gly Arg 
            180                 185                 190         


Val Leu Ser Leu Phe Glu Asp Glu Glu Lys Gln Gln Gln Ala His Asp 
        195                 200                 205             


Leu Phe Glu Glu Ala Ala His Gln Gly Cys Leu Thr Ser Ser Tyr Leu 
    210                 215                 220                 


Leu Trp Glu Ser Asp Arg Arg Thr Asp Val Ser Asp Pro Gly Arg Cys 
225                 230                 235                 240 


Leu His Ser Phe Arg Lys Leu Arg Asp Tyr Ala Ala Lys Gly Cys Trp 
                245                 250                 255     


Glu Ala Gln Leu Ser Leu Ala Lys Ala Cys Ala Asn Ala Asn Gln Leu 
            260                 265                 270         


Gly Leu Glu Val Arg Ala Ser Ser Glu Ile Val Cys Gln Leu Phe Gln 
        275                 280                 285             


Ala Ser Gln Ala Val Ser Lys Gln Gln Val Phe Ser Val Gln Lys Gly 
    290                 295                 300                 


Leu Asn Asp Thr Met Arg Tyr Ile Leu Ile Asp Trp Leu Val Glu Val 
305                 310                 315                 320 


Ala Thr Met Lys Asp Phe Thr Ser Leu Cys Leu His Leu Thr Val Glu 
                325                 330                 335     


Cys Val Asp Arg Tyr Leu Arg Arg Arg Leu Val Pro Arg Tyr Arg Leu 
            340                 345                 350         


Gln Leu Leu Gly Ile Ala Cys Met Val Ile Cys Thr Arg Phe Ile Ser 
        355                 360                 365             


Lys Glu Ile Leu Thr Ile Arg Glu Ala Val Trp Leu Thr Asp Asn Thr 
    370                 375                 380                 


Tyr Lys Tyr Glu Asp Leu Val Arg Met Met Gly Glu Ile Val Ser Ala 
385                 390                 395                 400 


Leu Glu Gly Lys Ile Arg Val Pro Thr Val Val Asp Tyr Lys Glu Val 
                405                 410                 415     


Leu Leu Thr Leu Val Pro Val Glu Leu Arg Thr Gln His Leu Cys Ser 
            420                 425                 430         


Phe Leu Cys Glu Leu Ser Leu Leu His Thr Ser Leu Ser Ala Tyr Ala 
        435                 440                 445             


Pro Ala Arg Leu Ala Ala Ala Ala Leu Leu Leu Ala Arg Leu Thr His 
    450                 455                 460                 


Gly Gln Thr Gln Pro Trp Thr Thr Gln Leu Trp Asp Leu Thr Gly Phe 
465                 470                 475                 480 


Ser Tyr Glu Asp Leu Ile Pro Cys Val Leu Ser Leu His Lys Lys Cys 
                485                 490                 495     


Phe His Asp Asp Ala Pro Lys Asp Tyr Arg Gln Val Ser Leu Thr Ala 
            500                 505                 510         


Val Lys Gln Arg Phe Glu Asp Lys Arg Tyr Gly Glu Ile Ser Gln Glu 
        515                 520                 525             


Glu Val Leu Ser Tyr Ser Gln Leu Cys Ala Ala Leu Gly Val Thr Gln 
    530                 535                 540                 


Asp Ser Pro Asp Pro Pro Thr Phe Leu Ser Thr Gly Glu Ile His Ala 
545                 550                 555                 560 


Phe Leu Ser Ser Pro Ser Gly Arg Arg Thr Lys Arg Lys Arg Glu Asn 
                565                 570                 575     


Ser Leu Gln Glu Asp Arg Gly Ser Phe Val Thr Thr Pro Thr Ala Glu 
            580                 585                 590         


Leu Ser Ser Gln Glu Glu Thr Leu Leu Gly Ser Phe Leu Asp Trp Ser 
        595                 600                 605             


Leu Asp Cys Cys Ser Gly Tyr Glu Gly Asp Gln Glu Ser Glu Gly Glu 
    610                 615                 620                 


Lys Glu Gly Asp Val Thr Ala Pro Ser Gly Ile Leu Asp Val Thr Val 
625                 630                 635                 640 


Val Tyr Leu Asn Pro Glu Gln His Cys Cys Gln Glu Ser Ser Asp Glu 
                645                 650                 655     


Glu Ala Cys Pro Glu Asp Lys Gly Pro Gln Asp Pro Gln Ala Leu Ala 
            660                 665                 670         


Leu Asp Thr Gln Ile Pro Ala Thr Pro Gly Pro Lys Pro Leu Val Arg 
        675                 680                 685             


Thr Ser Arg Glu Pro Gly Lys Asp Val Thr Thr Ser Gly Tyr Ser Ser 
    690                 695                 700                 


Val Ser Thr Ala Ser Pro Thr Ser Ser Val Asp Gly Gly Leu Gly Ala 
705                 710                 715                 720 


Leu Pro Gln Pro Thr Ser Val Leu Ser Leu Asp Ser Asp Ser His Thr 
                725                 730                 735     


Gln Pro Cys His His Gln Ala Arg Lys Ser Cys Leu Gln Cys Arg Pro 
            740                 745                 750         


Pro Ser Pro Pro Glu Ser Ser Val Pro Gln Gln Gln Val Lys Arg Ile 
        755                 760                 765             


Asn Leu Cys Ile His Ser Glu Glu Glu Asp Met Asn Leu Gly Leu Val 
    770                 775                 780                 


Arg Leu 
785     


<210>  4
<211>  4196
<212>  DNA
<213>  Homo sapiens

<400>  4
ggtctgcgcc tgcgcgaggg ctacgcgcgc tccggccggg gcgcgggcgc gctctcaggc       60

gggctccggc ggcagcgacg cgagcgcggc gatggggagc ggcggcgtgg tccactgtag      120

gtgtgccaag tgtttctgtt atcctacaaa gcgaagaata aggaggaggc cccgaaacct      180

gaccatcttg agtctccccg aagatgtgct ctttcacatc ctgaaatggc tttctgtaga      240

ggacatcctg gccgtccgag ctggctgctg aaaaggggaa tttcgaagct gctgtgaagc      300

tgggcatagc ctacctctac aatgaaggcc tgtctgtgtc tgatgaggcc cgcgcagaag      360

tgaatggcct gaaggcctct cgcttcttca gtctcgctga gcggctgaat gtgggtgccg      420

cacctttcat ctggctcttc atccgccctc cgtggtcggt gagcggaagc tgctgcaagg      480

ccgtggttca cgagagcctc agggcagagt gccagctgca gaggactcac aaagcatcca      540

tattgcactg cttgggcaga gtgctgagtc tgttcgagga tgaggagaag cagcagcagg      600

cccatgacct gtttgaggag gctgctcatc agggatgtct gaccagctcc tacctcctct      660

gggaaagcga caggaggaca gatgtgtcag atcctgggcg atgcctccac agcttccgaa      720

aactcaggga ctacgctgcc aaaggctgct gggaagcgca gctgtcttta gccaaagcct      780

gtgcaaatgc aaaccagctt ggactggagg tgagagcttc cagtgagatc gtctgccagc      840

tatttcaggc ttcccaggct gtcagtaaac aacaagtctt ctccgtgcag aagggactca      900

atgacacaat gaggtacatt ctgatcgact ggctggtgga agttgccacc atgaaggact      960

tcacaagcct gtgcctgcac ctgaccgtgg agtgtgtgga ccggtacctg cggaggaggc     1020

tggtgccgcg gtacaggctc cagctgctgg gcatcgcctg catggtcatc tgcacccggt     1080

ttatcagtaa agagatcctg accatccggg aggccgtatg gctcacggac aacacttaca     1140

agtacgagga cctggtgaga atgatgggcg agatcgtctc cgccttggaa gggaagattc     1200

gagtccccac tgtggtggat tacaaggagg tcctgctgac gctagtccct gtggagctga     1260

gaacccagca cctgtgcagc ttcctctgcg agctctccct gctgcacacc agcctgtccg     1320

cctacgcccc agcccgcctg gctgccgcag ccctgctcct ggccagactg acgcacgggc     1380

agacacagcc ctggaccact cagctgtggg acctcaccgg attctcctat gaagacctca     1440

ttccctgcgt cttgagcctc cataagaagt gcttccatga tgacgccccc aaggactaca     1500

ggcaagtctc tctgaccgcc gtgaagcagc ggtttgagga caagcgctat ggagaaatca     1560

gccaggaaga ggtgctgagc tacagccagt tgtgtgctgc attaggagtg acacaagaca     1620

gccccgaccc cccgactttc ctcagcacag gggagatcca cgccttcctc agctctccct     1680

cggggcggag aaccaaacgg aagcgggaga acagcctcca ggaagacaga ggcagcttcg     1740

ttaccacccc cactgcggag ctgtccagcc aggaggagac gctgctgggc agcttcctcg     1800

actggagcct ggactgctgc tctggctatg aaggcgacca ggagagtgag ggcgagaagg     1860

agggcgacgt gacagctccc agcggcatcc tcgatgtcac cgtggtctac ctgaacccag     1920

aacagcattg ctgccaggaa tccagtgatg aggaggcttg tccagaggac aagggacccc     1980

aggacccaca ggcactggcg ctggacaccc agatccctgc aacccctgga cccaaacccc     2040

tggtccgcac cagccgggag ccagggaagg acgtcacgac ctcagggtac tcctccgtca     2100

gcaccgcaag tcccacaagc tccgtggacg gtggcttggg ggccctgccc caacctacct     2160

cagtgctgtc cctggacagt gactcgcaca cacagccctg ccaccatcag gccaggaagt     2220

catgtttaca gtgtcgtccc ccaagtcccc cggagagcag tgttccccag caacaggtga     2280

agcggataaa cctatgcata cacagtgagg aggaggacat gaacctgggc cttgtgaggc     2340

tgtaagtgtg tcagcacatt tgccgcagtg gatgtgtact gagggggctg gaggcgaagg     2400

gtgggagcat agcataggaa cgctgcatag accatggagg cctttgcgca gagagcagag     2460

aggatgactt gcggccacca agtttctgtc tccgcgggag tcccgtgcaa gccatcagaa     2520

tgttgaaatg agggtgaaga gctcagatcc ctctctttgg aaagtttagc ctggaagcag     2580

ttggccacac tgtgtggagg gcacctctct gtcccttccg tgtctcactg tctctggaag     2640

cttcagccca tgtgtgtcct ggtgttccca gccccaccag agccccgtgc cgggagctga     2700

cagctttcac gcttaaggca cgtgtgacct gggtagtcag acaccacttg agcccctgcc     2760

cacatctgct ggtttggggc ttcagtgggg agctgacagc tgtgagcaca ccactgtccc     2820

ctcatccacc tcggcctgca tggggcaccc acttccttct gggtggggct tccatggtaa     2880

gggggcctgc gtccctgcac actgcgagga ctgccttggc cacaggccca ctccctacga     2940

cacgtgactc gttttagagc tctgtcccag aggcgttcgt atgtgaccca cagatggcgt     3000

caatgtgaac acctctcttt gtgctgaatt tctgggccat tcttttcctg tcttatttct     3060

aaatttcctt cttccaagat gaaaacaaaa gaaaaactta aaacagaagg tattaaaaaa     3120

acaagagatt cccaccatta tttaggttca cctgcaaaac aaaaatctta ctccagcccc     3180

tcaatgccat cctgacacac tttatgcaaa aagaattttc ccagataggc tagccagaaa     3240

aaacttcaag tcctctgtaa catctgaggt gaccaagagg cagaagagca gagcagtcgg     3300

gggccgtgtc ctggctgatc ccaactgcag ctctgctgtg ggggcccgtg ggagggaggc     3360

agacccctgg gctttcctgc tggccacgga gactctgctc ctgcatggaa agggagcctg     3420

ggagccagca gcccacgcct ggggagcctg cctggggcca tgtgaccatg gcctctccct     3480

gggaacgggc tgaccacaac acaccctgct gccatccact tctgtttact ctgcaaatgt     3540

aagaaagaac cacttggcca gaagtgtccc ccagatgctt tttttttttt ttttttggag     3600

acagttttgc tcttgtctcc ccggctggag tgcagtggca tgatctcaac tctcaactca     3660

ctgtaacctc cgcctcccgg atactcctgc ctcagcctcc tgggtagctg ggattacaag     3720

cacccaacca cgcccagcta atttttgtat tttcggtaga gacgggattt caccatgttg     3780

gccaggctag tctcgaactc atgacctcaa gtgatccgcc cacttcggtc tcccaaagtg     3840

ctgggattac aggcatgagc cacggcgcct ggcccccaaa tgctcttgaa ccggaaaccc     3900

agggatggga gatgctcact gagctgctgc ttttatgtgt gctggtgcta tgtgtgttca     3960

tgtccgcggc agctgtcttt ttgctactat aagggaattc tggccaccct gggtggggtg     4020

tggtcggggt gagaacccaa gcgttggaac tgtagacccg tcctgtcgac tgtgtgcccc     4080

tgggcatgtg tgagcctcag tttcctcatc tgtaaggggg gcaatgatac ctacctcaca     4140

ggggtgttgt gaggattaaa tgtgaggagg atagtggcaa aaaaaaaaaa aaaaaa         4196


<210>  5
<211>  1437
<212>  DNA
<213>  Homo sapiens

<400>  5
atgaggtaca ttctgatcga ctggctggtg gaagttgcca ccatgaagga cttcacaagc       60

ctgtgcctgc acctgaccgt ggagtgtgtg gaccggtacc tgcggaggag gctggtgccg      120

cggtacaggc tccagctgct gggcatcgcc tgcatggtca tctgcacccg gtttatcagt      180

aaagagatcc tgaccatccg ggaggccgta tggctcacgg acaacactta caagtacgag      240

gacctggtga gaatgatggg cgagatcgtc tccgccttgg aagggaagat tcgagtcccc      300

actgtggtgg attacaagga ggtcctgctg acgctagtcc ctgtggagct gagaacccag      360

cacctgtgca gcttcctctg cgagctctcc ctgctgcaca ccagcctgtc cgcctacgcc      420

ccagcccgcc tggctgccgc agccctgctc ctggccagac tgacgcacgg gcagacacag      480

ccctggacca ctcagctgtg ggacctcacc ggattctcct atgaagacct cattccctgc      540

gtcttgagcc tccataagaa gtgcttccat gatgacgccc ccaaggacta caggcaagtc      600

tctctgaccg ccgtgaagca gcggtttgag gacaagcgct atggagaaat cagccaggaa      660

gaggtgctga gctacagcca gttgtgtgct gcattaggag tgacacaaga cagccccgac      720

cccccgactt tcctcagcac aggggagatc cacgccttcc tcagctctcc ctcggggcgg      780

agaaccaaac ggaagcggga gaacagcctc caggaagaca gaggcagctt cgttaccacc      840

cccactgcgg agctgtccag ccaggaggag acgctgctgg gcagcttcct cgactggagc      900

ctggactgct gctctggcta tgaaggcgac caggagagtg agggcgagaa ggagggcgac      960

gtgacagctc ccagcggcat cctcgatgtc accgtggtct acctgaaccc agaacagcat     1020

tgctgccagg aatccagtga tgaggaggct tgtccagagg acaagggacc ccaggaccca     1080

caggcactgg cgctggacac ccagatccct gcaacccctg gacccaaacc cctggtccgc     1140

accagccggg agccagggaa ggacgtcacg acctcagggt actcctccgt cagcaccgca     1200

agtcccacaa gctccgtgga cggtggcttg ggggccctgc cccaacctac ctcagtgctg     1260

tccctggaca gtgactcgca cacacagccc tgccaccatc aggccaggaa gtcatgttta     1320

cagtgtcgtc ccccaagtcc cccggagagc agtgttcccc agcaacaggt gaagcggata     1380

aacctatgca tacacagtga ggaggaggac atgaacctgg gccttgtgag gctgtaa        1437


<210>  6
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Tyr Ile Leu Ile Asp Trp Leu Val Glu Val Ala Thr Met Lys 
1               5                   10                  15      


Asp Phe Thr Ser Leu Cys Leu His Leu Thr Val Glu Cys Val Asp Arg 
            20                  25                  30          


Tyr Leu Arg Arg Arg Leu Val Pro Arg Tyr Arg Leu Gln Leu Leu Gly 
        35                  40                  45              


Ile Ala Cys Met Val Ile Cys Thr Arg Phe Ile Ser Lys Glu Ile Leu 
    50                  55                  60                  


Thr Ile Arg Glu Ala Val Trp Leu Thr Asp Asn Thr Tyr Lys Tyr Glu 
65                  70                  75                  80  


Asp Leu Val Arg Met Met Gly Glu Ile Val Ser Ala Leu Glu Gly Lys 
                85                  90                  95      


Ile Arg Val Pro Thr Val Val Asp Tyr Lys Glu Val Leu Leu Thr Leu 
            100                 105                 110         


Val Pro Val Glu Leu Arg Thr Gln His Leu Cys Ser Phe Leu Cys Glu 
        115                 120                 125             


Leu Ser Leu Leu His Thr Ser Leu Ser Ala Tyr Ala Pro Ala Arg Leu 
    130                 135                 140                 


Ala Ala Ala Ala Leu Leu Leu Ala Arg Leu Thr His Gly Gln Thr Gln 
145                 150                 155                 160 


Pro Trp Thr Thr Gln Leu Trp Asp Leu Thr Gly Phe Ser Tyr Glu Asp 
                165                 170                 175     


Leu Ile Pro Cys Val Leu Ser Leu His Lys Lys Cys Phe His Asp Asp 
            180                 185                 190         


Ala Pro Lys Asp Tyr Arg Gln Val Ser Leu Thr Ala Val Lys Gln Arg 
        195                 200                 205             


Phe Glu Asp Lys Arg Tyr Gly Glu Ile Ser Gln Glu Glu Val Leu Ser 
    210                 215                 220                 


Tyr Ser Gln Leu Cys Ala Ala Leu Gly Val Thr Gln Asp Ser Pro Asp 
225                 230                 235                 240 


Pro Pro Thr Phe Leu Ser Thr Gly Glu Ile His Ala Phe Leu Ser Ser 
                245                 250                 255     


Pro Ser Gly Arg Arg Thr Lys Arg Lys Arg Glu Asn Ser Leu Gln Glu 
            260                 265                 270         


Asp Arg Gly Ser Phe Val Thr Thr Pro Thr Ala Glu Leu Ser Ser Gln 
        275                 280                 285             


Glu Glu Thr Leu Leu Gly Ser Phe Leu Asp Trp Ser Leu Asp Cys Cys 
    290                 295                 300                 


Ser Gly Tyr Glu Gly Asp Gln Glu Ser Glu Gly Glu Lys Glu Gly Asp 
305                 310                 315                 320 


Val Thr Ala Pro Ser Gly Ile Leu Asp Val Thr Val Val Tyr Leu Asn 
                325                 330                 335     


Pro Glu Gln His Cys Cys Gln Glu Ser Ser Asp Glu Glu Ala Cys Pro 
            340                 345                 350         


Glu Asp Lys Gly Pro Gln Asp Pro Gln Ala Leu Ala Leu Asp Thr Gln 
        355                 360                 365             


Ile Pro Ala Thr Pro Gly Pro Lys Pro Leu Val Arg Thr Ser Arg Glu 
    370                 375                 380                 


Pro Gly Lys Asp Val Thr Thr Ser Gly Tyr Ser Ser Val Ser Thr Ala 
385                 390                 395                 400 


Ser Pro Thr Ser Ser Val Asp Gly Gly Leu Gly Ala Leu Pro Gln Pro 
                405                 410                 415     


Thr Ser Val Leu Ser Leu Asp Ser Asp Ser His Thr Gln Pro Cys His 
            420                 425                 430         


His Gln Ala Arg Lys Ser Cys Leu Gln Cys Arg Pro Pro Ser Pro Pro 
        435                 440                 445             


Glu Ser Ser Val Pro Gln Gln Gln Val Lys Arg Ile Asn Leu Cys Ile 
    450                 455                 460                 


His Ser Glu Glu Glu Asp Met Asn Leu Gly Leu Val Arg Leu 
465                 470                 475             


<210>  7
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  7

Met Gly Ser Gly Gly Val Val His Cys Arg Cys Ala Lys Cys Phe Cys 
1               5                   10                  15      


Tyr Pro Thr Lys Arg Arg Ile Arg Arg Arg Pro Arg Asn Leu Thr Ile 
            20                  25                  30          


Leu Ser Leu Pro Glu Asp Val Leu Phe His Ile Leu Lys Trp Leu Ser 
        35                  40                  45              


Val Glu Asp Ile Leu Ala Val Arg Ala Val His Ser Gln Leu Lys Asp 
    50                  55                  60                  


Leu Val Asp Asn His Ala Ser Val Trp Ala Cys Ala Ser Phe Gln Glu 
65                  70                  75                  80  


Leu Trp Pro Ser Pro Gly Asn Leu Lys Leu Phe Glu Arg Ala Ala Glu 
                85                  90                  95      


Lys Gly Asn Phe Glu Ala Ala Val Lys Leu Gly Ile Ala Tyr Leu Tyr 
            100                 105                 110         


Asn Glu Gly Leu Ser Val Ser Asp Glu Ala Arg Ala Glu Val Asn Gly 
        115                 120                 125             


Leu Lys Ala Ser Arg Phe Phe Ser Leu Ala Glu Arg Leu Asn Val Gly 
    130                 135                 140                 


Ala Ala Pro Phe Ile Trp Leu Phe Ile Arg Pro Pro Trp Ser Val Ser 
145                 150                 155                 160 


Gly Ser Cys Cys Lys Ala Val Val His Glu Ser Leu Arg Ala Glu Cys 
                165                 170                 175     


Gln Leu Gln Arg Thr His Lys Ala Ser Ile Leu His Cys Leu Gly Arg 
            180                 185                 190         


Val Leu Ser Leu Phe Glu Asp Glu Glu Lys Gln Gln Gln Ala His Asp 
        195                 200                 205             


Leu Phe Glu Glu Ala Ala His Gln Gly Cys Leu Thr Ser Ser Tyr Leu 
    210                 215                 220                 


Leu Trp Glu Ser Asp Arg Arg Thr Asp Val Ser Asp Pro Gly Arg Cys 
225                 230                 235                 240 


Leu His Ser Phe Arg Lys Leu Arg Asp Tyr Ala Ala Lys Gly Cys Trp 
                245                 250                 255     


Glu Ala Gln Leu Ser Leu Ala Lys Ala Cys Ala Asn Ala Asn Gln Leu 
            260                 265                 270         


Gly Leu Glu Val Arg Ala Ser Ser Glu Ile Val Cys Gln Leu Phe Gln 
        275                 280                 285             


Ala Ser Gln Ala Val Ser Lys Gln Gln Val Phe Ser Val Gln Lys Gly 
    290                 295                 300                 


Leu Asn Asp Thr Ala Ala Tyr Ile Leu Ile Asp Trp Leu Val Glu Val 
305                 310                 315                 320 


Ala Thr Met Lys Asp Phe Thr Ser Leu Cys Leu His Leu Thr Val Glu 
                325                 330                 335     


Cys Val Asp Arg Tyr Leu Arg Arg Arg Leu Val Pro Arg Tyr Arg Leu 
            340                 345                 350         


Gln Leu Leu Gly Ile Ala Cys Met Val Ile Cys Thr Arg Phe Ile Ser 
        355                 360                 365             


Lys Glu Ile Leu Thr Ile Arg Glu Ala Val Trp Leu Thr Asp Asn Thr 
    370                 375                 380                 


Tyr Lys Tyr Glu Asp Leu Val Arg Met Met Gly Glu Ile Val Ser Ala 
385                 390                 395                 400 


Leu Glu Gly Lys Ile Arg Val Pro Thr Val Val Asp Tyr Lys Glu Val 
                405                 410                 415     


Leu Leu Thr Leu Val Pro Val Glu Leu Arg Thr Gln His Leu Cys Ser 
            420                 425                 430         


Phe Leu Cys Glu Leu Ser Leu Leu His Thr Ser Leu Ser Ala Tyr Ala 
        435                 440                 445             


Pro Ala Arg Leu Ala Ala Ala Ala Leu Leu Leu Ala Arg Leu Thr His 
    450                 455                 460                 


Gly Gln Thr Gln Pro Trp Thr Thr Gln Leu Trp Asp Leu Thr Gly Phe 
465                 470                 475                 480 


Ser Tyr Glu Asp Leu Ile Pro Cys Val Leu Ser Leu His Lys Lys Cys 
                485                 490                 495     


Phe His Asp Asp Ala Pro Lys Asp Tyr Arg Gln Val Ser Leu Thr Ala 
            500                 505                 510         


Val Lys Gln Arg Phe Glu Asp Lys Arg Tyr Gly Glu Ile Ser Gln Glu 
        515                 520                 525             


Glu Val Leu Ser Tyr Ser Gln Leu Cys Ala Ala Leu Gly Val Thr Gln 
    530                 535                 540                 


Asp Ser Pro Asp Pro Pro Thr Phe Leu Ser Thr Gly Glu Ile His Ala 
545                 550                 555                 560 


Phe Leu Ser Ser Pro Ser Gly Arg Arg Thr Lys Arg Lys Arg Glu Asn 
                565                 570                 575     


Ser Leu Gln Glu Asp Arg Gly Ser Phe Val Thr Thr Pro Thr Ala Glu 
            580                 585                 590         


Leu Ser Ser Gln Glu Glu Thr Leu Leu Gly Ser Phe Leu Asp Trp Ser 
        595                 600                 605             


Leu Asp Cys Cys Ser Gly Tyr Glu Gly Asp Gln Glu Ser Glu Gly Glu 
    610                 615                 620                 


Lys Glu Gly Asp Val Thr Ala Pro Ser Gly Ile Leu Asp Val Thr Val 
625                 630                 635                 640 


Val Tyr Leu Asn Pro Glu Gln His Cys Cys Gln Glu Ser Ser Asp Glu 
                645                 650                 655     


Glu Ala Cys Pro Glu Asp Lys Gly Pro Gln Asp Pro Gln Ala Leu Ala 
            660                 665                 670         


Leu Asp Thr Gln Ile Pro Ala Thr Pro Gly Pro Lys Pro Leu Val Arg 
        675                 680                 685             


Thr Ser Arg Glu Pro Gly Lys Asp Val Thr Thr Ser Gly Tyr Ser Ser 
    690                 695                 700                 


Val Ser Thr Ala Ser Pro Thr Ser Ser Val Asp Gly Gly Leu Gly Ala 
705                 710                 715                 720 


Leu Pro Gln Pro Thr Ser Val Leu Ser Leu Asp Ser Asp Ser His Thr 
                725                 730                 735     


Gln Pro Cys His His Gln Ala Arg Lys Ser Cys Leu Gln Cys Arg Pro 
            740                 745                 750         


Pro Ser Pro Pro Glu Ser Ser Val Pro Gln Gln Gln Val Lys Arg Ile 
        755                 760                 765             


Asn Leu Cys Ile His Ser Glu Glu Glu Asp Met Asn Leu Gly Leu Val 
    770                 775                 780                 


Arg Leu 
785     


