                         SEQUENCE LISTING

<110>  Research Institute at Nationwide Children's Hospital Inc.
 
<120>  Gene Therapy Targeting Cochlear Cells

<130>  28335/54882

<150>  US 62/923,398
<151>  2019-10-18

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1
ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat       60

ttatttttta attattttgt gcagcgatgg gggcgggggg gggggggggg cgcgcgccag      120

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      180

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      240

ataaaaagcg aagcgcgcgg cgggcgggag                                       270


<210>  2
<211>  2212
<212>  DNA
<213>  Homo sapiens

<400>  2
ggagaagcat agttgcacgc gacctggtgt gtgatctccg agtgggtggg ggagggtcga       60

ggagggaaaa aaaaataaga cgttgcagaa gagacccgga aagggccttt tttttggttg      120

agctggtgtc ccagtgctgc ctccgatcct gagcctccga gcctttgcag tgcaatgtcc      180

cgcctgctgc atgcagaaga gtgggctgaa gtgaaggagt tgggagacca ccatcgccag      240

ccccagccgc atcatctccc gcaaccgccg ccgccgccgc agccacctgc aactttgcag      300

gcgagagagc atcccgtcta cccgcctgag ctgtccctcc tggacagcac cgacccacgc      360

gcctggctgg ctcccacttt gcagggcatc tgcacggcac gcgccgccca gtatttgcta      420

cattccccgg agctgggtgc ctcagaggcc gctgcgcccc gggacgaggt ggacggccgg      480

ggggagctgg taaggaggag cagcggcggt gccagcagca gcaagagccc cgggccggtg      540

aaagtgcggg aacagctgtg caagctgaaa ggcggggtgg tggtagacga gctgggctgc      600

agccgccaac gggccccttc cagcaaacag gtgaatgggg tgcagaagca gagacggcta      660

gcagccaacg ccagggagcg gcgcaggatg catgggctga accacgcctt cgaccagctg      720

cgcaatgtta tcccgtcgtt caacaacgac aagaagctgt ccaaatatga gaccctgcag      780

atggcccaaa tctacatcaa cgccttgtcc gagctgctac aaacgcccag cggaggggaa      840

cagccaccgc cgcctccagc ctcctgcaaa agcgaccacc accaccttcg caccgcggcc      900

tcctatgaag ggggcgcggg caacgcgacc gcagctgggg ctcagcaggc ttccggaggg      960

agccagcggc cgaccccgcc cgggagttgc cggactcgct tctcagcccc agcttctgcg     1020

ggagggtact cggtgcagct ggacgctctg cacttctcga ctttcgagga cagcgccctg     1080

acagcgatga tggcgcaaaa gaatttgtct ccttctctcc ccgggagcat cttgcagcca     1140

gtgcaggagg aaaacagcaa aacttcgcct cggtcccaca gaagcgacgg ggaattttcc     1200

ccccattccc attacagtga ctcggatgag gcaagttagg aaggtgacag aagcctgaaa     1260

actgagacag aaacaaaact gccctttccc agtgcgcggg aagccccgcg gttaaagatc     1320

cccgcaccct ttaatttttg ctctgcgatg gtcgttgttt agcaacgact tggcttcaga     1380

tggcagctac atttgatggt ttgcaaatgc cgccgctgtt ccaaacttcc tacggtccat     1440

attgtttgat gaaaactttc tgttaaaatt gtgtcctttc cgcccacctt ctgctccccc     1500

tttagataga tacggtataa ttgtaggtac ccgtatatgg catcattatt ctagttccct     1560

gctgccaata cgctgctaaa acgtcgcatc ttctctgtca ctggtttggg tttaatttat     1620

tttacgccct gggcatccat ccttgtgtgt tgcgcactca agtgtgggag atttagtctt     1680

ccgaagttgt tttccaaaat gcacaatgaa acgcaaaatt agtgcttcca aagtggataa     1740

cttttgacta tggaattgtt agaaaacaag aaactttaag gtttatatat tgtataaaca     1800

tacccagtat gtgcatccga tcgcgagaac gttggcgtct tttaggaaac tccgcgcacg     1860

cactttatca gccgctgctg cggtggtggc tccaggagaa actcaactgc caattgcaga     1920

ccagtttttt tttttttaaa cacagccact tataattctt aagctctttg caaatgtttg     1980

tttaaaaaat gaaaaattaa aaaaaatcta gtagtgtcaa acgcatttgg tcaattttat     2040

tttgctttgt taatattaga aaacttattt attattgttt gctaccattt ctacttatct     2100

tgattcattt tttacgtttt ctactcgaga tcattttatt ttaatttagc aaagccaact     2160

gcccttgttt aatgtatttt gttttgcaaa tgattaaaat aaatgtgaaa ag             2212


<210>  3
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Arg Leu Leu His Ala Glu Glu Trp Ala Glu Val Lys Glu Leu 
1               5                   10                  15      


Gly Asp His His Arg Gln Pro Gln Pro His His Leu Pro Gln Pro Pro 
            20                  25                  30          


Pro Pro Pro Gln Pro Pro Ala Thr Leu Gln Ala Arg Glu His Pro Val 
        35                  40                  45              


Tyr Pro Pro Glu Leu Ser Leu Leu Asp Ser Thr Asp Pro Arg Ala Trp 
    50                  55                  60                  


Leu Ala Pro Thr Leu Gln Gly Ile Cys Thr Ala Arg Ala Ala Gln Tyr 
65                  70                  75                  80  


Leu Leu His Ser Pro Glu Leu Gly Ala Ser Glu Ala Ala Ala Pro Arg 
                85                  90                  95      


Asp Glu Val Asp Gly Arg Gly Glu Leu Val Arg Arg Ser Ser Gly Gly 
            100                 105                 110         


Ala Ser Ser Ser Lys Ser Pro Gly Pro Val Lys Val Arg Glu Gln Leu 
        115                 120                 125             


Cys Lys Leu Lys Gly Gly Val Val Val Asp Glu Leu Gly Cys Ser Arg 
    130                 135                 140                 


Gln Arg Ala Pro Ser Ser Lys Gln Val Asn Gly Val Gln Lys Gln Arg 
145                 150                 155                 160 


Arg Leu Ala Ala Asn Ala Arg Glu Arg Arg Arg Met His Gly Leu Asn 
                165                 170                 175     


His Ala Phe Asp Gln Leu Arg Asn Val Ile Pro Ser Phe Asn Asn Asp 
            180                 185                 190         


Lys Lys Leu Ser Lys Tyr Glu Thr Leu Gln Met Ala Gln Ile Tyr Ile 
        195                 200                 205             


Asn Ala Leu Ser Glu Leu Leu Gln Thr Pro Ser Gly Gly Glu Gln Pro 
    210                 215                 220                 


Pro Pro Pro Pro Ala Ser Cys Lys Ser Asp His His His Leu Arg Thr 
225                 230                 235                 240 


Ala Ala Ser Tyr Glu Gly Gly Ala Gly Asn Ala Thr Ala Ala Gly Ala 
                245                 250                 255     


Gln Gln Ala Ser Gly Gly Ser Gln Arg Pro Thr Pro Pro Gly Ser Cys 
            260                 265                 270         


Arg Thr Arg Phe Ser Ala Pro Ala Ser Ala Gly Gly Tyr Ser Val Gln 
        275                 280                 285             


Leu Asp Ala Leu His Phe Ser Thr Phe Glu Asp Ser Ala Leu Thr Ala 
    290                 295                 300                 


Met Met Ala Gln Lys Asn Leu Ser Pro Ser Leu Pro Gly Ser Ile Leu 
305                 310                 315                 320 


Gln Pro Val Gln Glu Glu Asn Ser Lys Thr Ser Pro Arg Ser His Arg 
                325                 330                 335     


Ser Asp Gly Glu Phe Ser Pro His Ser His Tyr Ser Asp Ser Asp Glu 
            340                 345                 350         


Ala Ser 
        


<210>  4
<211>  7214
<212>  DNA
<213>  Homo sapiens

<400>  4
gtgagtcgct gcaggagcag cttagctcgg cttggttgcc ttggtctctg tgggcagcat       60

cggagggggg tcgggaggag gaggaggagg cagcggcaga gaagagagag gcgtgtgagc      120

cgtgctccac cggctagctc cttcccgctg ctcctgcctg gcagtgccag gcagcccaca      180

ccagcatggc cttgctcatc cacctcaaga cagtctcgga gctgcggggc aggggcgacc      240

ggatcgccaa agtgactttc cgagggcaat ccttctactc tcgggtcctg gagaactgtg      300

aggatgtggc tgactttgat gagacatttc ggtggccggt ggccagcagc atcgacagaa      360

atgagatgct ggagattcag gttttcaact acagcaaagt cttcagcaac aagctcatcg      420

ggaccttccg catggtgctg cagaaggtgg tagaggagag ccatgtggag gtgactgaca      480

cgctgattga tgacaacaat gctatcatca agaccagcct gtgcgtggag gtccggtatc      540

aggccactga cggcacagtg ggctcctggg acgatgggga cttcctggga gatgagtctc      600

ttcaagagga agagaaggac agccaagaga cggatggact gctcccaggc tcccggccca      660

gctcccggcc cccaggagag aagagcttcc ggagagccgg gaggagcgtg ttctccgcca      720

tgaagctcgg caaaaaccgg tctcacaagg aggagcccca aagaccagat gaaccggcgg      780

tgctggagat ggaagacctt gaccatctgg ccattcggct aggagatgga ctggatcccg      840

actcggtgtc tctagcctca gtcacagctc tcaccactaa tgtctccaac aagcgatcta      900

agccagacat taagatggag ccaagtgctg ggcggcccat ggattaccag gtcagcatca      960

cggtgatcga ggcccggcag ctggtgggct tgaacatgga ccctgtggtg tgcgtggagg     1020

tgggtgacga caagaagtac acatccatga aggagtccac taactgcccc tattacaacg     1080

agtacttcgt cttcgacttc catgtctctc cggatgtcat gtttgacaag atcatcaaga     1140

tttcggtgat tcactccaag aacctgctgc gcagtggcac cctggtgggc tccttcaaaa     1200

tggacgtggg aaccgtgtac tcgcagccag agcaccagtt ccatcacaag tgggccatcc     1260

tgtctgaccc cgatgacatc tcctcggggc tgaagggcta cgtgaagtgt gacgttgccg     1320

tggtgggcaa aggggacaac atcaagacgc cccacaaggc caatgagacc gacgaagatg     1380

acattgaggg gaacttgctg ctccccgagg gggtgccccc cgaacgccag tgggcccggt     1440

tctatgtgaa aatttaccga gcagaggggc tgccccgtat gaacacaagc ctcatggcca     1500

atgtaaagaa ggctttcatc ggtgaaaaca aggacctcgt ggacccctac gtgcaagtct     1560

tctttgctgg ccagaagggc aagacttcag tgcagaagag cagctatgag cccctgtgga     1620

atgagcaggt cgtctttaca gacctcttcc ccccactctg caaacgcatg aaggtgcaga     1680

tccgagactc ggacaaggtc aacgacgtgg ccatcggcac ccacttcatt gacctgcgca     1740

agatttctaa tgacggagac aaaggcttcc tgcccacact gggcccagcc tgggtgaaca     1800

tgtacggctc cacacgtaac tacacgctgc tggatgagca tcaggacctg aacgagggcc     1860

tgggggaggg tgtgtccttc cgggcccggc tcctgctggg cctggctgtg gagatcgtag     1920

acacctccaa ccctgagctc accagctcca cagaggtgca ggtggagcag gccacgccca     1980

tctcggagag ctgtgcaggt aaaatggaag aattctttct ctttggagcc ttcctggagg     2040

cctcaatgat cgaccggaga aacggagaca agcccatcac ctttgaggtc accataggca     2100

actatgggaa cgaagttgat ggcctgtccc ggccccagcg gcctcggccc cggaaggagc     2160

cgggggatga ggaagaagta gacctgattc agaacgcaag tgatgacgag gccggtgatg     2220

ccggggacct ggcctcagtc tcctccactc caccaatgcg gccccaggtc accgacagga     2280

actacttcca tctgccctac ctggagcgaa agccctgcat ctacatcaag agctggtggc     2340

cggaccagcg ccgccgcctc tacaatgcca acatcatgga ccacattgcc gacaagctgg     2400

aagaaggcct gaacgacata caggagatga tcaaaacgga gaagtcctac cctgagcgtc     2460

gcctgcgggg cgtcctggag gagctgagct gtggctgctg ccgcttcctc tccctcgctg     2520

acaaggacca gggccactca tcccgcacca ggcttgaccg ggagcgcctc aagtcctgca     2580

tgagggagct ggaaaacatg gggcagcagg ccaggatgct gcgggcccag gtgaagcggc     2640

acacggtgcg ggacaagctg aggctgtgcc agaacttcct gcagaagctg cgcttcctgg     2700

cggacgagcc ccagcacagc attcccgaca tcttcatctg gatgatgagc aacaacaagc     2760

gtgtcgccta tgcccgtgtg ccctccaagg acctgctctt ctccatcgtg gaggaggaga     2820

ctggcaagga ctgcgccaag gtcaagacgc tcttccttaa gctgccaggg aagcggggct     2880

tcggctcggc aggctggaca gtgcaggcca aggtggagct gtacctgtgg ctgggcctca     2940

gcaaacagcg caaggagttc ctgtgcggcc tgccctgtgg cttccaggag gtcaaggcag     3000

cccagggcct gggcctgcat gccttcccac ccgtcagcct ggtctacacc aagaagcagg     3060

cgttccagct ccgagcgcac atgtaccagg cccgcagcct ctttgccgcc gacagcagcg     3120

gactctcaga cccctttgcc cgcgtcttct tcatcaatca gagtcagtgc acagaggtgc     3180

tgaatgagac cctgtgtccc acctgggacc agatgctggt gttcgacaac ctggagctct     3240

atggtgaagc tcatgagctg agggacgatc cgcccatcat tgtcattgaa atctatgacc     3300

aggattccat gggcaaagct gacttcatgg gccggacctt cgccaaaccc ctggtgaaga     3360

tggcagacga ggcgtactgc ccaccccgct tcccacctca gctcgagtac taccagatct     3420

accgtggcaa cgccacagct ggagacctgc tggcggcctt cgagctgctg cagattggac     3480

cagcagggaa ggctgacctg ccccccatca atggcccggt ggacgtggac cgaggtccca     3540

tcatgcccgt gcccatgggc atccggcccg tgctcagcaa gtaccgagtg gaggtgctgt     3600

tctggggcct acgggaccta aagcgggtga acctggccca ggtggaccgg ccacgggtgg     3660

acatcgagtg tgcagggaag ggggtgcagt cgtccctgat ccacaattat aagaagaacc     3720

ccaacttcaa caccctcgtc aagtggtttg aagtggacct cccagagaac gagctgctgc     3780

acccgccctt gaacatccgt gtggtggact gccgggcctt cggtcgctac acactggtgg     3840

gctcccatgc cgtcagctcc ctgcgacgct tcatctaccg gcccccagac cgctcggccc     3900

ccagctggaa caccacggtc aggcttctcc ggcgctgccg tgtgctgtgc aatgggggct     3960

cctcctctca ctccacaggg gaggttgtgg tgactatgga gccagaggta cccatcaaga     4020

aactggagac catggtgaag ctggacgcga cttctgaagc tgttgtcaag gtggatgtgg     4080

ctgaggagga gaaggagaag aagaagaaga agaagggcac tgcggaggag ccagaggagg     4140

aggagccaga cgagagcatg ctggactggt ggtccaagta ctttgcctcc attgacacca     4200

tgaaggagca acttcgacaa caagagccct ctggaattga cttggaggag aaggaggaag     4260

tggacaatac cgagggcctg aaggggtcaa tgaagggcaa ggagaaggca agggctgcca     4320

aagaggagaa gaagaagaaa actcagagct ctggctctgg ccaggggtcc gaggcccccg     4380

agaagaagaa acccaagatt gatgagctta aggtataccc caaagagctg gagtccgagt     4440

ttgataactt tgaggactgg ctgcacactt tcaacttgct tcggggcaag accggggatg     4500

atgaggatgg ctccaccgag gaggagcgca ttgtgggacg cttcaagggc tccctctgcg     4560

tgtacaaagt gccactccca gaggacgtgt cccgggaagc cggctacgac tccacctacg     4620

gcatgttcca gggcatcccg agcaatgacc ccatcaatgt gctggtccga gtctatgtgg     4680

tccgggccac ggacctgcac cctgctgaca tcaacggcaa agctgacccc tacatcgcca     4740

tccggctagg caagactgac atccgcgaca aggagaacta catctccaag cagctcaacc     4800

ctgtctttgg gaagtccttt gacatcgagg cctccttccc catggaatcc atgctgacgg     4860

tggctgtgta tgactgggac ctggtgggca ctgatgacct cattggggaa accaagatcg     4920

acctggagaa ccgcttctac agcaagcacc gcgccacctg cggcatcgcc cagacctact     4980

ccacacatgg ctacaatatc tggcgggacc ccatgaagcc cagccagatc ctgacccgcc     5040

tctgcaaaga cggcaaagtg gacggccccc actttgggcc ccctgggaga gtgaaggtgg     5100

ccaaccgcgt cttcactggg ccctctgaga ttgaggacga gaacggtcag aggaagccca     5160

cagacgagca tgtggcgctg ttggccctga ggcactggga ggacatcccc cgcgcaggct     5220

gccgcctggt gccagagcat gtggagacga ggccgctgct caaccccgac aagccgggca     5280

tcgagcaggg ccgcctggag ctgtgggtgg acatgttccc catggacatg ccagcccctg     5340

ggacgcctct ggacatctca cctcggaagc ccaagaagta cgagctgcgg gtcatcatct     5400

ggaacacaga tgaggtggtc ttggaggacg acgacttctt cacaggggag aagtccagtg     5460

acatcttcgt gagggggtgg ctgaagggcc agcaggagga caagcaggac acagacgtcc     5520

actaccactc cctcactggc gagggcaact tcaactggcg ctacctgttc cccttcgact     5580

acctggcggc ggaggagaag atcgtcatct ccaagaagga gtccatgttc tcctgggacg     5640

agaccgagta caagatcccc gcgcggctca ccctgcagat ctgggatgcg gaccacttct     5700

ccgctgacga cttcctgggg gccatcgagc tggacctgaa ccggttcccg cggggcgcaa     5760

agacagccaa gcagtgcacc atggagatgg ccaccgggga ggtggacgtg cccctcgtgt     5820

ccatcttcaa gcaaaagcgc gtcaaaggct ggtggcccct cctggcccgc aatgagaacg     5880

atgagtttga gctcacgggc aaggtggagg ctgagctgca tttactgaca gcagaggagg     5940

cagagaagaa cccagtgggc ctggcccgca atgaacctga ccccctagag aaacccaacc     6000

ggcccgacac gagcttcatc tggttcctga accctctcaa gtcggctcgc tacttcttgt     6060

ggcacacgta tcgctggctg ctcctcaaac tgttgctgct cctgctgctg ctcctcctcc     6120

tcgccctgtt cctctactct gtgcctggct acctggtcaa gaaaatcctc ggggcctgag     6180

cccagtggcc tcctggccgg cccgacacgg ccttcgtctg gttcctcaac cctctcaagt     6240

ccatcaagta cctcatctgc acccggtaca agtggctcat catcaagatc gtgctggcgc     6300

tgttggggct gctcatgttg gggctcttcc tctacagcct ccctggctac atggtcaaaa     6360

agctccttgg ggcatgaagg ccgccagctc ccgccagccg ctccccagcc ctgccgcatt     6420

tcctttcagt ggcttggact ctttcccatc tcccctgggg agcctgagga gcccagcgtc     6480

cactcttcat gccttgggcc gagcctgcct cctgcttgcg ggggccgcct gtcctcactg     6540

ccccaggctg cggcttgccc agtcccgccc ctctgacccc tgcctgtggg ctggggagcc     6600

ttggatgggg tggggacctg gaatgggtct ctcttgcccc acctggctga ggcgccaccc     6660

ttcttcaggc ccaggctcca gaggaagact cctgaaaccc tccccaggtc ttccaagtac     6720

aggattgaag ctttagtgaa attaaccaag gaccatgggt cagtgcccag ggctttaaaa     6780

agaatgaacg agcaaaaggt atccccgccg tgacccctgc agatagcacc ggtctttgat     6840

ccgcagcagg ggccagaccc tgcccacaag tcccagcgcg gctgcttctg ccactgctgg     6900

gctccacttg gctcctctca cttcccaggg ggtcgcctgt cctgcctgtg ggtttccatg     6960

gcttcccaga gctccctctg ccccagccag cgcctccagg cccagctgag gagctgtgag     7020

aagcagcaga ggggactccc catcccgggc acaccctgtc ctcccacccc tgcccccttg     7080

cccttccagc cctttcagct gcagctggga gctggcccgt caagtgctgc ccctgcctgt     7140

gtctgggttt ctgttggctg tttttctttt cttgagtggt gatttttctc taaataaaag     7200

aagtcaagca ctga                                                       7214


<210>  5
<211>  1997
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Leu Leu Ile His Leu Lys Thr Val Ser Glu Leu Arg Gly Arg 
1               5                   10                  15      


Gly Asp Arg Ile Ala Lys Val Thr Phe Arg Gly Gln Ser Phe Tyr Ser 
            20                  25                  30          


Arg Val Leu Glu Asn Cys Glu Asp Val Ala Asp Phe Asp Glu Thr Phe 
        35                  40                  45              


Arg Trp Pro Val Ala Ser Ser Ile Asp Arg Asn Glu Met Leu Glu Ile 
    50                  55                  60                  


Gln Val Phe Asn Tyr Ser Lys Val Phe Ser Asn Lys Leu Ile Gly Thr 
65                  70                  75                  80  


Phe Arg Met Val Leu Gln Lys Val Val Glu Glu Ser His Val Glu Val 
                85                  90                  95      


Thr Asp Thr Leu Ile Asp Asp Asn Asn Ala Ile Ile Lys Thr Ser Leu 
            100                 105                 110         


Cys Val Glu Val Arg Tyr Gln Ala Thr Asp Gly Thr Val Gly Ser Trp 
        115                 120                 125             


Asp Asp Gly Asp Phe Leu Gly Asp Glu Ser Leu Gln Glu Glu Glu Lys 
    130                 135                 140                 


Asp Ser Gln Glu Thr Asp Gly Leu Leu Pro Gly Ser Arg Pro Ser Ser 
145                 150                 155                 160 


Arg Pro Pro Gly Glu Lys Ser Phe Arg Arg Ala Gly Arg Ser Val Phe 
                165                 170                 175     


Ser Ala Met Lys Leu Gly Lys Asn Arg Ser His Lys Glu Glu Pro Gln 
            180                 185                 190         


Arg Pro Asp Glu Pro Ala Val Leu Glu Met Glu Asp Leu Asp His Leu 
        195                 200                 205             


Ala Ile Arg Leu Gly Asp Gly Leu Asp Pro Asp Ser Val Ser Leu Ala 
    210                 215                 220                 


Ser Val Thr Ala Leu Thr Thr Asn Val Ser Asn Lys Arg Ser Lys Pro 
225                 230                 235                 240 


Asp Ile Lys Met Glu Pro Ser Ala Gly Arg Pro Met Asp Tyr Gln Val 
                245                 250                 255     


Ser Ile Thr Val Ile Glu Ala Arg Gln Leu Val Gly Leu Asn Met Asp 
            260                 265                 270         


Pro Val Val Cys Val Glu Val Gly Asp Asp Lys Lys Tyr Thr Ser Met 
        275                 280                 285             


Lys Glu Ser Thr Asn Cys Pro Tyr Tyr Asn Glu Tyr Phe Val Phe Asp 
    290                 295                 300                 


Phe His Val Ser Pro Asp Val Met Phe Asp Lys Ile Ile Lys Ile Ser 
305                 310                 315                 320 


Val Ile His Ser Lys Asn Leu Leu Arg Ser Gly Thr Leu Val Gly Ser 
                325                 330                 335     


Phe Lys Met Asp Val Gly Thr Val Tyr Ser Gln Pro Glu His Gln Phe 
            340                 345                 350         


His His Lys Trp Ala Ile Leu Ser Asp Pro Asp Asp Ile Ser Ser Gly 
        355                 360                 365             


Leu Lys Gly Tyr Val Lys Cys Asp Val Ala Val Val Gly Lys Gly Asp 
    370                 375                 380                 


Asn Ile Lys Thr Pro His Lys Ala Asn Glu Thr Asp Glu Asp Asp Ile 
385                 390                 395                 400 


Glu Gly Asn Leu Leu Leu Pro Glu Gly Val Pro Pro Glu Arg Gln Trp 
                405                 410                 415     


Ala Arg Phe Tyr Val Lys Ile Tyr Arg Ala Glu Gly Leu Pro Arg Met 
            420                 425                 430         


Asn Thr Ser Leu Met Ala Asn Val Lys Lys Ala Phe Ile Gly Glu Asn 
        435                 440                 445             


Lys Asp Leu Val Asp Pro Tyr Val Gln Val Phe Phe Ala Gly Gln Lys 
    450                 455                 460                 


Gly Lys Thr Ser Val Gln Lys Ser Ser Tyr Glu Pro Leu Trp Asn Glu 
465                 470                 475                 480 


Gln Val Val Phe Thr Asp Leu Phe Pro Pro Leu Cys Lys Arg Met Lys 
                485                 490                 495     


Val Gln Ile Arg Asp Ser Asp Lys Val Asn Asp Val Ala Ile Gly Thr 
            500                 505                 510         


His Phe Ile Asp Leu Arg Lys Ile Ser Asn Asp Gly Asp Lys Gly Phe 
        515                 520                 525             


Leu Pro Thr Leu Gly Pro Ala Trp Val Asn Met Tyr Gly Ser Thr Arg 
    530                 535                 540                 


Asn Tyr Thr Leu Leu Asp Glu His Gln Asp Leu Asn Glu Gly Leu Gly 
545                 550                 555                 560 


Glu Gly Val Ser Phe Arg Ala Arg Leu Leu Leu Gly Leu Ala Val Glu 
                565                 570                 575     


Ile Val Asp Thr Ser Asn Pro Glu Leu Thr Ser Ser Thr Glu Val Gln 
            580                 585                 590         


Val Glu Gln Ala Thr Pro Ile Ser Glu Ser Cys Ala Gly Lys Met Glu 
        595                 600                 605             


Glu Phe Phe Leu Phe Gly Ala Phe Leu Glu Ala Ser Met Ile Asp Arg 
    610                 615                 620                 


Arg Asn Gly Asp Lys Pro Ile Thr Phe Glu Val Thr Ile Gly Asn Tyr 
625                 630                 635                 640 


Gly Asn Glu Val Asp Gly Leu Ser Arg Pro Gln Arg Pro Arg Pro Arg 
                645                 650                 655     


Lys Glu Pro Gly Asp Glu Glu Glu Val Asp Leu Ile Gln Asn Ala Ser 
            660                 665                 670         


Asp Asp Glu Ala Gly Asp Ala Gly Asp Leu Ala Ser Val Ser Ser Thr 
        675                 680                 685             


Pro Pro Met Arg Pro Gln Val Thr Asp Arg Asn Tyr Phe His Leu Pro 
    690                 695                 700                 


Tyr Leu Glu Arg Lys Pro Cys Ile Tyr Ile Lys Ser Trp Trp Pro Asp 
705                 710                 715                 720 


Gln Arg Arg Arg Leu Tyr Asn Ala Asn Ile Met Asp His Ile Ala Asp 
                725                 730                 735     


Lys Leu Glu Glu Gly Leu Asn Asp Ile Gln Glu Met Ile Lys Thr Glu 
            740                 745                 750         


Lys Ser Tyr Pro Glu Arg Arg Leu Arg Gly Val Leu Glu Glu Leu Ser 
        755                 760                 765             


Cys Gly Cys Cys Arg Phe Leu Ser Leu Ala Asp Lys Asp Gln Gly His 
    770                 775                 780                 


Ser Ser Arg Thr Arg Leu Asp Arg Glu Arg Leu Lys Ser Cys Met Arg 
785                 790                 795                 800 


Glu Leu Glu Asn Met Gly Gln Gln Ala Arg Met Leu Arg Ala Gln Val 
                805                 810                 815     


Lys Arg His Thr Val Arg Asp Lys Leu Arg Leu Cys Gln Asn Phe Leu 
            820                 825                 830         


Gln Lys Leu Arg Phe Leu Ala Asp Glu Pro Gln His Ser Ile Pro Asp 
        835                 840                 845             


Ile Phe Ile Trp Met Met Ser Asn Asn Lys Arg Val Ala Tyr Ala Arg 
    850                 855                 860                 


Val Pro Ser Lys Asp Leu Leu Phe Ser Ile Val Glu Glu Glu Thr Gly 
865                 870                 875                 880 


Lys Asp Cys Ala Lys Val Lys Thr Leu Phe Leu Lys Leu Pro Gly Lys 
                885                 890                 895     


Arg Gly Phe Gly Ser Ala Gly Trp Thr Val Gln Ala Lys Val Glu Leu 
            900                 905                 910         


Tyr Leu Trp Leu Gly Leu Ser Lys Gln Arg Lys Glu Phe Leu Cys Gly 
        915                 920                 925             


Leu Pro Cys Gly Phe Gln Glu Val Lys Ala Ala Gln Gly Leu Gly Leu 
    930                 935                 940                 


His Ala Phe Pro Pro Val Ser Leu Val Tyr Thr Lys Lys Gln Ala Phe 
945                 950                 955                 960 


Gln Leu Arg Ala His Met Tyr Gln Ala Arg Ser Leu Phe Ala Ala Asp 
                965                 970                 975     


Ser Ser Gly Leu Ser Asp Pro Phe Ala Arg Val Phe Phe Ile Asn Gln 
            980                 985                 990         


Ser Gln Cys Thr Glu Val Leu Asn  Glu Thr Leu Cys Pro  Thr Trp Asp 
        995                 1000                 1005             


Gln Met  Leu Val Phe Asp Asn  Leu Glu Leu Tyr Gly  Glu Ala His 
    1010                 1015                 1020             


Glu Leu  Arg Asp Asp Pro Pro  Ile Ile Val Ile Glu  Ile Tyr Asp 
    1025                 1030                 1035             


Gln Asp  Ser Met Gly Lys Ala  Asp Phe Met Gly Arg  Thr Phe Ala 
    1040                 1045                 1050             


Lys Pro  Leu Val Lys Met Ala  Asp Glu Ala Tyr Cys  Pro Pro Arg 
    1055                 1060                 1065             


Phe Pro  Pro Gln Leu Glu Tyr  Tyr Gln Ile Tyr Arg  Gly Asn Ala 
    1070                 1075                 1080             


Thr Ala  Gly Asp Leu Leu Ala  Ala Phe Glu Leu Leu  Gln Ile Gly 
    1085                 1090                 1095             


Pro Ala  Gly Lys Ala Asp Leu  Pro Pro Ile Asn Gly  Pro Val Asp 
    1100                 1105                 1110             


Val Asp  Arg Gly Pro Ile Met  Pro Val Pro Met Gly  Ile Arg Pro 
    1115                 1120                 1125             


Val Leu  Ser Lys Tyr Arg Val  Glu Val Leu Phe Trp  Gly Leu Arg 
    1130                 1135                 1140             


Asp Leu  Lys Arg Val Asn Leu  Ala Gln Val Asp Arg  Pro Arg Val 
    1145                 1150                 1155             


Asp Ile  Glu Cys Ala Gly Lys  Gly Val Gln Ser Ser  Leu Ile His 
    1160                 1165                 1170             


Asn Tyr  Lys Lys Asn Pro Asn  Phe Asn Thr Leu Val  Lys Trp Phe 
    1175                 1180                 1185             


Glu Val  Asp Leu Pro Glu Asn  Glu Leu Leu His Pro  Pro Leu Asn 
    1190                 1195                 1200             


Ile Arg  Val Val Asp Cys Arg  Ala Phe Gly Arg Tyr  Thr Leu Val 
    1205                 1210                 1215             


Gly Ser  His Ala Val Ser Ser  Leu Arg Arg Phe Ile  Tyr Arg Pro 
    1220                 1225                 1230             


Pro Asp  Arg Ser Ala Pro Ser  Trp Asn Thr Thr Val  Arg Leu Leu 
    1235                 1240                 1245             


Arg Arg  Cys Arg Val Leu Cys  Asn Gly Gly Ser Ser  Ser His Ser 
    1250                 1255                 1260             


Thr Gly  Glu Val Val Val Thr  Met Glu Pro Glu Val  Pro Ile Lys 
    1265                 1270                 1275             


Lys Leu  Glu Thr Met Val Lys  Leu Asp Ala Thr Ser  Glu Ala Val 
    1280                 1285                 1290             


Val Lys  Val Asp Val Ala Glu  Glu Glu Lys Glu Lys  Lys Lys Lys 
    1295                 1300                 1305             


Lys Lys  Gly Thr Ala Glu Glu  Pro Glu Glu Glu Glu  Pro Asp Glu 
    1310                 1315                 1320             


Ser Met  Leu Asp Trp Trp Ser  Lys Tyr Phe Ala Ser  Ile Asp Thr 
    1325                 1330                 1335             


Met Lys  Glu Gln Leu Arg Gln  Gln Glu Pro Ser Gly  Ile Asp Leu 
    1340                 1345                 1350             


Glu Glu  Lys Glu Glu Val Asp  Asn Thr Glu Gly Leu  Lys Gly Ser 
    1355                 1360                 1365             


Met Lys  Gly Lys Glu Lys Ala  Arg Ala Ala Lys Glu  Glu Lys Lys 
    1370                 1375                 1380             


Lys Lys  Thr Gln Ser Ser Gly  Ser Gly Gln Gly Ser  Glu Ala Pro 
    1385                 1390                 1395             


Glu Lys  Lys Lys Pro Lys Ile  Asp Glu Leu Lys Val  Tyr Pro Lys 
    1400                 1405                 1410             


Glu Leu  Glu Ser Glu Phe Asp  Asn Phe Glu Asp Trp  Leu His Thr 
    1415                 1420                 1425             


Phe Asn  Leu Leu Arg Gly Lys  Thr Gly Asp Asp Glu  Asp Gly Ser 
    1430                 1435                 1440             


Thr Glu  Glu Glu Arg Ile Val  Gly Arg Phe Lys Gly  Ser Leu Cys 
    1445                 1450                 1455             


Val Tyr  Lys Val Pro Leu Pro  Glu Asp Val Ser Arg  Glu Ala Gly 
    1460                 1465                 1470             


Tyr Asp  Ser Thr Tyr Gly Met  Phe Gln Gly Ile Pro  Ser Asn Asp 
    1475                 1480                 1485             


Pro Ile  Asn Val Leu Val Arg  Val Tyr Val Val Arg  Ala Thr Asp 
    1490                 1495                 1500             


Leu His  Pro Ala Asp Ile Asn  Gly Lys Ala Asp Pro  Tyr Ile Ala 
    1505                 1510                 1515             


Ile Arg  Leu Gly Lys Thr Asp  Ile Arg Asp Lys Glu  Asn Tyr Ile 
    1520                 1525                 1530             


Ser Lys  Gln Leu Asn Pro Val  Phe Gly Lys Ser Phe  Asp Ile Glu 
    1535                 1540                 1545             


Ala Ser  Phe Pro Met Glu Ser  Met Leu Thr Val Ala  Val Tyr Asp 
    1550                 1555                 1560             


Trp Asp  Leu Val Gly Thr Asp  Asp Leu Ile Gly Glu  Thr Lys Ile 
    1565                 1570                 1575             


Asp Leu  Glu Asn Arg Phe Tyr  Ser Lys His Arg Ala  Thr Cys Gly 
    1580                 1585                 1590             


Ile Ala  Gln Thr Tyr Ser Thr  His Gly Tyr Asn Ile  Trp Arg Asp 
    1595                 1600                 1605             


Pro Met  Lys Pro Ser Gln Ile  Leu Thr Arg Leu Cys  Lys Asp Gly 
    1610                 1615                 1620             


Lys Val  Asp Gly Pro His Phe  Gly Pro Pro Gly Arg  Val Lys Val 
    1625                 1630                 1635             


Ala Asn  Arg Val Phe Thr Gly  Pro Ser Glu Ile Glu  Asp Glu Asn 
    1640                 1645                 1650             


Gly Gln  Arg Lys Pro Thr Asp  Glu His Val Ala Leu  Leu Ala Leu 
    1655                 1660                 1665             


Arg His  Trp Glu Asp Ile Pro  Arg Ala Gly Cys Arg  Leu Val Pro 
    1670                 1675                 1680             


Glu His  Val Glu Thr Arg Pro  Leu Leu Asn Pro Asp  Lys Pro Gly 
    1685                 1690                 1695             


Ile Glu  Gln Gly Arg Leu Glu  Leu Trp Val Asp Met  Phe Pro Met 
    1700                 1705                 1710             


Asp Met  Pro Ala Pro Gly Thr  Pro Leu Asp Ile Ser  Pro Arg Lys 
    1715                 1720                 1725             


Pro Lys  Lys Tyr Glu Leu Arg  Val Ile Ile Trp Asn  Thr Asp Glu 
    1730                 1735                 1740             


Val Val  Leu Glu Asp Asp Asp  Phe Phe Thr Gly Glu  Lys Ser Ser 
    1745                 1750                 1755             


Asp Ile  Phe Val Arg Gly Trp  Leu Lys Gly Gln Gln  Glu Asp Lys 
    1760                 1765                 1770             


Gln Asp  Thr Asp Val His Tyr  His Ser Leu Thr Gly  Glu Gly Asn 
    1775                 1780                 1785             


Phe Asn  Trp Arg Tyr Leu Phe  Pro Phe Asp Tyr Leu  Ala Ala Glu 
    1790                 1795                 1800             


Glu Lys  Ile Val Ile Ser Lys  Lys Glu Ser Met Phe  Ser Trp Asp 
    1805                 1810                 1815             


Glu Thr  Glu Tyr Lys Ile Pro  Ala Arg Leu Thr Leu  Gln Ile Trp 
    1820                 1825                 1830             


Asp Ala  Asp His Phe Ser Ala  Asp Asp Phe Leu Gly  Ala Ile Glu 
    1835                 1840                 1845             


Leu Asp  Leu Asn Arg Phe Pro  Arg Gly Ala Lys Thr  Ala Lys Gln 
    1850                 1855                 1860             


Cys Thr  Met Glu Met Ala Thr  Gly Glu Val Asp Val  Pro Leu Val 
    1865                 1870                 1875             


Ser Ile  Phe Lys Gln Lys Arg  Val Lys Gly Trp Trp  Pro Leu Leu 
    1880                 1885                 1890             


Ala Arg  Asn Glu Asn Asp Glu  Phe Glu Leu Thr Gly  Lys Val Glu 
    1895                 1900                 1905             


Ala Glu  Leu His Leu Leu Thr  Ala Glu Glu Ala Glu  Lys Asn Pro 
    1910                 1915                 1920             


Val Gly  Leu Ala Arg Asn Glu  Pro Asp Pro Leu Glu  Lys Pro Asn 
    1925                 1930                 1935             


Arg Pro  Asp Thr Ser Phe Ile  Trp Phe Leu Asn Pro  Leu Lys Ser 
    1940                 1945                 1950             


Ala Arg  Tyr Phe Leu Trp His  Thr Tyr Arg Trp Leu  Leu Leu Lys 
    1955                 1960                 1965             


Leu Leu  Leu Leu Leu Leu Leu  Leu Leu Leu Leu Ala  Leu Phe Leu 
    1970                 1975                 1980             


Tyr Ser  Val Pro Gly Tyr Leu  Val Lys Lys Ile Leu  Gly Ala 
    1985                 1990                 1995         


<210>  6
<211>  2290
<212>  DNA
<213>  Homo sapiens

<400>  6
gttgcggccc cgcagcgccc gcgcgctcct ctccccgact cggagcccct cggcggcgcc       60

cggcccagga cccgcctagg agcgcaggag ccccagcgca gagaccccaa cgccgagacc      120

cccgccccgg ccccgccgcg cttcctcccg acgcagagca aaccgcccag agtagaagat      180

ggattggggc acgctgcaga cgatcctggg gggtgtgaac aaacactcca ccagcattgg      240

aaagatctgg ctcaccgtcc tcttcatttt tcgcattatg atcctcgttg tggctgcaaa      300

ggaggtgtgg ggagatgagc aggccgactt tgtctgcaac accctgcagc caggctgcaa      360

gaacgtgtgc tacgatcact acttccccat ctcccacatc cggctatggg ccctgcagct      420

gatcttcgtg tccacgccag cgctcctagt ggccatgcac gtggcctacc ggagacatga      480

gaagaagagg aagttcatca agggggagat aaagagtgaa tttaaggaca tcgaggagat      540

caaaacccag aaggtccgca tcgaaggctc cctgtggtgg acctacacaa gcagcatctt      600

cttccgggtc atcttcgaag ccgccttcat gtacgtcttc tatgtcatgt acgacggctt      660

ctccatgcag cggctggtga agtgcaacgc ctggccttgt cccaacactg tggactgctt      720

tgtgtcccgg cccacggaga agactgtctt cacagtgttc atgattgcag tgtctggaat      780

ttgcatcctg ctgaatgtca ctgaattgtg ttatttgcta attagatatt gttctgggaa      840

gtcaaaaaag ccagtttaac gcattgccca gttgttagat taagaaatag acagcatgag      900

agggatgagg caacccgtgc tcagctgtca aggctcagtc gctagcattt cccaacacaa      960

agattctgac cttaaatgca accatttgaa acccctgtag gcctcaggtg aaactccaga     1020

tgccacaatg gagctctgct cccctaaagc ctcaaaacaa aggcctaatt ctatgcctgt     1080

cttaattttc tttcacttaa gttagttcca ctgagacccc aggctgttag gggttattgg     1140

tgtaaggtac tttcatattt taaacagagg atatcggcat ttgtttcttt ctctgaggac     1200

aagagaaaaa agccaggttc cacagaggac acagagaagg tttgggtgtc ctcctggggt     1260

tctttttgcc aactttcccc acgttaaagg tgaacattgg ttctttcatt tgctttggaa     1320

gttttaatct ctaacagtgg acaaagttac cagtgcctta aactctgtta cactttttgg     1380

aagtgaaaac tttgtagtat gataggttat tttgatgtaa agatgttctg gataccatta     1440

tatgttcccc ctgtttcaga ggctcagatt gtaatatgta aatggtatgt cattcgctac     1500

tatgatttaa tttgaaatat ggtcttttgg ttatgaatac tttgcagcac agctgagagg     1560

ctgtctgttg tattcattgt ggtcatagca cctaacaaca ttgtagcctc aatcgagtga     1620

gacagactag aagttcctag tgatggctta tgatagcaaa tggcctcatg tcaaatattt     1680

agatgtaatt ttgtgtaaga aatacagact ggatgtacca ccaactacta cctgtaatga     1740

caggcctgtc caacacatct cccttttcca tgactgtggt agccagcatc ggaaagaacg     1800

ctgatttaaa gaggtcgctt gggaatttta ttgacacagt accatttaat ggggaggaca     1860

aaatggggca ggggagggag aagtttctgt cgttaaaaac agatttggaa agactggact     1920

ctaaagtctg ttgattaaag atgagctttg tctacttcaa aagtttgttt gcttacccct     1980

tcagcctcca attttttaag tgaaaatata gctaataaca tgtgaaaaga atagaagcta     2040

aggtttagat aaatattgag cagatctata ggaagattga acctgaatat tgccattatg     2100

cttgacatgg tttccaaaaa atggtactcc acatatttca gtgagggtaa gtattttcct     2160

gttgtcaaga atagcattgt aaaagcattt tgtaataata aagaatagct ttaatgatat     2220

gcttgtaact aaaataattt tgtaatgtat caaatacatt taaaacatta aaatataatc     2280

tctataataa                                                            2290


<210>  7
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Trp Gly Thr Leu Gln Thr Ile Leu Gly Gly Val Asn Lys His 
1               5                   10                  15      


Ser Thr Ser Ile Gly Lys Ile Trp Leu Thr Val Leu Phe Ile Phe Arg 
            20                  25                  30          


Ile Met Ile Leu Val Val Ala Ala Lys Glu Val Trp Gly Asp Glu Gln 
        35                  40                  45              


Ala Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
    50                  55                  60                  


Tyr Asp His Tyr Phe Pro Ile Ser His Ile Arg Leu Trp Ala Leu Gln 
65                  70                  75                  80  


Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
                85                  90                  95      


Tyr Arg Arg His Glu Lys Lys Arg Lys Phe Ile Lys Gly Glu Ile Lys 
            100                 105                 110         


Ser Glu Phe Lys Asp Ile Glu Glu Ile Lys Thr Gln Lys Val Arg Ile 
        115                 120                 125             


Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Val 
    130                 135                 140                 


Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Val Met Tyr Asp Gly 
145                 150                 155                 160 


Phe Ser Met Gln Arg Leu Val Lys Cys Asn Ala Trp Pro Cys Pro Asn 
                165                 170                 175     


Thr Val Asp Cys Phe Val Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
            180                 185                 190         


Val Phe Met Ile Ala Val Ser Gly Ile Cys Ile Leu Leu Asn Val Thr 
        195                 200                 205             


Glu Leu Cys Tyr Leu Leu Ile Arg Tyr Cys Ser Gly Lys Ser Lys Lys 
    210                 215                 220                 


Pro Val 
225     


<210>  8
<211>  2105
<212>  DNA
<213>  Homo sapiens

<400>  8
gtcatggcag cgccaggcgg caggtcggag ccgccgcagc tccccgagta cagctgcagc       60

tacatggtgt cgcggccggt ctacagcgag ctcgctttcc agcaacagca cgagcggcgc      120

ctgcaggagc gcaagacgct gcgggagagc ctggccaagt gctgcagttg ttcaagaaag      180

agagcctttg gtgtgctaaa gactcttgtg cccatcttgg agtggctccc caaataccga      240

gtcaaggaat ggctgcttag tgacgtcatt tcgggagtta gtactgggct agtggccacg      300

ctgcaaggga tggcatatgc cctactagct gcagttcctg tcggatatgg tctctactct      360

gcttttttcc ctatcctgac atactttatc tttggaacat caagacatat ctcagttgga      420

ccttttccag tggtgagttt aatggtggga tctgttgttc tgagcatggc ccccgacgaa      480

cactttctcg tatccagcag caatggaact gtattaaata ctactatgat agacactgca      540

gctagagata cagctagagt cctgattgcc agtgccctga ctctgctggt tggaattata      600

cagttgatat ttggtggctt gcagattgga ttcatagtga ggtacttggc agatcctttg      660

gttggtggct tcacaacagc tgctgccttc caagtgctgg tctcacagct aaagattgtc      720

ctcaatgttt caaccaaaaa ctacaatgga gttctctcta ttatctatac gctggttgag      780

atttttcaaa atattggtga taccaatctt gctgatttca ctgctggatt gctcaccatt      840

gtcgtctgta tggcagttaa ggaattaaat gatcggttta gacacaaaat cccagtccct      900

attcctatag aagtaattgt gacgataatt gctactgcca tttcatatgg agccaacctg      960

gaaaaaaatt acaatgctgg cattgttaaa tccatcccaa gggggttttt gcctcctgaa     1020

cttccacctg tgagcttgtt ctcggagatg ctggctgcat cattttccat cgctgtggtg     1080

gcttatgcta ttgcagtgtc agtaggaaaa gtatatgcca ccaagtatga ttacaccatc     1140

gatgggaacc aggaattcat tgcctttggg atcagcaaca tcttctcagg attcttctct     1200

tgttttgtgg ccaccactgc tctttcccgc acggccgtcc aggagagcac tggaggaaag     1260

acacagagct tctaatcttc atcttggctc tgccccagct gtctcaacag agaattcatt     1320

ggtcatctaa tcaaacgaga gagtagtccc caccccctca gcctctctcc taactagtat     1380

ggatcttagg agagctattt ttgccagcga aggtaaagtt tctgaagctt ccttttaccc     1440

ctgctattgc cccgttactc catagtcact gtttcaggct gccttggggc aaagctctga     1500

gcctgcctcc gtggaactgt cagaggaggc aggagacaca atcccacctc tcaatgtgca     1560

aatgtggcat ttcgaatttg caataggatg agtaaattta ttttctctga gactttaatg     1620

agaccatgtg ctacaagtac gaagtgttat cagagttgct attatagctg cagcttcaat     1680

aatgcagaaa aatcagctat gtgccatgag aatttatttc ccaagaatac gacaatgatc     1740

tctgttgttg ggaaaggggg gattggtcca tgtttcctgc catggtaaat aactagaagc     1800

ttggcctgaa tggacgccga aaccgcaggt gtgtactatc accaaataaa atccctgtca     1860

aactggcttt aatttcatag gatcagtccc catattttct ttaacttctc tgccatagca     1920

tatatagatg ccatttttgt tcagttttgt ggcttgagca aataactatc acttttctcg     1980

acagtattga gcagaagggg gagacaggga agtatgaagt gtgtctgtga acaggctgtc     2040

tcatacacac atccagtgag ctggaagaca caagggagaa ggacgaatcc ttttcatagg     2100

aggtg                                                                 2105


<210>  9
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Pro Gly Gly Arg Ser Glu Pro Pro Gln Leu Pro Glu Tyr 
1               5                   10                  15      


Ser Cys Ser Tyr Met Val Ser Arg Pro Val Tyr Ser Glu Leu Ala Phe 
            20                  25                  30          


Gln Gln Gln His Glu Arg Arg Leu Gln Glu Arg Lys Thr Leu Arg Glu 
        35                  40                  45              


Ser Leu Ala Lys Cys Cys Ser Cys Ser Arg Lys Arg Ala Phe Gly Val 
    50                  55                  60                  


Leu Lys Thr Leu Val Pro Ile Leu Glu Trp Leu Pro Lys Tyr Arg Val 
65                  70                  75                  80  


Lys Glu Trp Leu Leu Ser Asp Val Ile Ser Gly Val Ser Thr Gly Leu 
                85                  90                  95      


Val Ala Thr Leu Gln Gly Met Ala Tyr Ala Leu Leu Ala Ala Val Pro 
            100                 105                 110         


Val Gly Tyr Gly Leu Tyr Ser Ala Phe Phe Pro Ile Leu Thr Tyr Phe 
        115                 120                 125             


Ile Phe Gly Thr Ser Arg His Ile Ser Val Gly Pro Phe Pro Val Val 
    130                 135                 140                 


Ser Leu Met Val Gly Ser Val Val Leu Ser Met Ala Pro Asp Glu His 
145                 150                 155                 160 


Phe Leu Val Ser Ser Ser Asn Gly Thr Val Leu Asn Thr Thr Met Ile 
                165                 170                 175     


Asp Thr Ala Ala Arg Asp Thr Ala Arg Val Leu Ile Ala Ser Ala Leu 
            180                 185                 190         


Thr Leu Leu Val Gly Ile Ile Gln Leu Ile Phe Gly Gly Leu Gln Ile 
        195                 200                 205             


Gly Phe Ile Val Arg Tyr Leu Ala Asp Pro Leu Val Gly Gly Phe Thr 
    210                 215                 220                 


Thr Ala Ala Ala Phe Gln Val Leu Val Ser Gln Leu Lys Ile Val Leu 
225                 230                 235                 240 


Asn Val Ser Thr Lys Asn Tyr Asn Gly Val Leu Ser Ile Ile Tyr Thr 
                245                 250                 255     


Leu Val Glu Ile Phe Gln Asn Ile Gly Asp Thr Asn Leu Ala Asp Phe 
            260                 265                 270         


Thr Ala Gly Leu Leu Thr Ile Val Val Cys Met Ala Val Lys Glu Leu 
        275                 280                 285             


Asn Asp Arg Phe Arg His Lys Ile Pro Val Pro Ile Pro Ile Glu Val 
    290                 295                 300                 


Ile Val Thr Ile Ile Ala Thr Ala Ile Ser Tyr Gly Ala Asn Leu Glu 
305                 310                 315                 320 


Lys Asn Tyr Asn Ala Gly Ile Val Lys Ser Ile Pro Arg Gly Phe Leu 
                325                 330                 335     


Pro Pro Glu Leu Pro Pro Val Ser Leu Phe Ser Glu Met Leu Ala Ala 
            340                 345                 350         


Ser Phe Ser Ile Ala Val Val Ala Tyr Ala Ile Ala Val Ser Val Gly 
        355                 360                 365             


Lys Val Tyr Ala Thr Lys Tyr Asp Tyr Thr Ile Asp Gly Asn Gln Glu 
    370                 375                 380                 


Phe Ile Ala Phe Gly Ile Ser Asn Ile Phe Ser Gly Phe Phe Ser Cys 
385                 390                 395                 400 


Phe Val Ala Thr Thr Ala Leu Ser Arg Thr Ala Val Gln Glu Ser Thr 
                405                 410                 415     


Gly Gly Lys Thr Gln Ser Phe 
            420             


<210>  10
<211>  3491
<212>  DNA
<213>  Homo sapiens

<400>  10
aattgtggct atagccgcct cgatcgctgt ctccccagcc tcgccgcggc cgctccggga       60

cgcgcccgcc cgccgcccgg ctctcccccc ctttgggctg ctgctgctgc tgctgtgact      120

gctgctgcga gaggaggagg aggaggagga agcagcgggg gggggagcgg ggggtggggg      180

gggagaccaa gaagtacagt tgggagcgag ggagcttcac ccccggggcg gtggttgttt      240

cttttttctt tctttctttt ttcttttcct tttttttttt ttttctaatt cctgaggggt      300

ggttgctgct tttgctacat gacttgccag cgcccgagcc tgcggtccaa ctgcgctgct      360

gccggagcgc tcagtgccgc cgctgccgcc cgcgcccccc gcgccccgtt cggcacccac      420

cggtcgccgc cgcccgccgc gccgctgtcc cgctcccgcg ccgccgccgc cgtttccccc      480

cgacgactgg gtgatgctgg acatgggaga taggaaagag gtgaaaatga tccccaagtc      540

ctcgttcagc atcaacagcc tggtgcccga ggcggtccag aacgacaacc accacgcgag      600

ccacggccac cacaacagcc accaccccca gcaccaccac caccaccacc accatcacca      660

ccacccgccg ccgcccgccc cgcaaccgcc gccgccgccg cagcagcagc agccgccgcc      720

gccgccgccc ccggcaccgc agccccccca gacgcggggc gccccggccg ccgacgacga      780

caagggcccc cagcagctgc tgctcccgcc gccgccaccg ccaccaccgg ccgccgccct      840

ggacggggct aaagcggacg ggctgggcgg caagggcgag ccgggcggcg ggccggggga      900

gctggcgccc gtcgggccgg acgagaagga gaagggcgcc ggcgccgggg gggaggagaa      960

gaagggggcg ggcgagggcg gcaaggacgg ggaggggggc aaggagggcg agaagaagaa     1020

cggcaagtac gagaagccgc cgttcagcta caacgcgctc atcatgatgg ccatccggca     1080

gagccccgag aagcggctca cgctcaacgg catctacgag ttcatcatga agaacttccc     1140

ttactaccgc gagaacaagc agggctggca gaactccatc cgccacaatc tgtccctcaa     1200

caagtgcttc gtgaaggtgc cgcgccacta cgacgacccg ggcaagggca actactggat     1260

gctggacccg tcgagcgacg acgtgttcat cggcggcacc acgggcaagc tgcggcgccg     1320

ctccaccacc tcgcgggcca agctggcctt caagcgcggt gcgcgcctca cctccaccgg     1380

cctcaccttc atggaccgcg ccggctccct ctactggccc atgtcgccct tcctgtccct     1440

gcaccacccc cgcgccagca gcactttgag ttacaacggc accacgtcgg cctaccccag     1500

ccaccccatg ccctacagct ccgtgttgac tcagaactcg ctgggcaaca accactcctt     1560

ctccaccgcc aacggcctga gcgtggaccg gctggtcaac ggggagatcc cgtacgccac     1620

gcaccacctc acggccgccg cgctagccgc ctcggtgccc tgcggcctgt cggtgccctg     1680

ctctgggacc tactccctca acccctgctc cgtcaacctg ctcgcgggcc agaccagtta     1740

ctttttcccc cacgtcccgc acccgtcaat gacttcgcag agcagcacgt ccatgagcgc     1800

cagggccgcg tcctcctcca cgtcgccgca ggccccctcg accctgccct gtgagtcttt     1860

aagaccctct ttgccaagtt ttacgacggg actgtctggg ggactgtctg attatttcac     1920

acatcaaaat caggggtctt cttccaaccc tttaatacat taacatccct gggaccagac     1980

tgtaagtgaa cgttttacac acatttgcat tgtaaatgat aattaaaaaa ataagtccag     2040

gtatttttta ttaagccccc ccctcccatt tctgtacgtt tgttcagtct ctagggttgt     2100

ttattattct aacaaggtgt ggagtgtcag cgaggtgcaa tgtggggaga atacattgta     2160

gaatataagg tttggaagtc aaattatagt agaatgtgta tctaaatagt gactgctttg     2220

ccatttcatt caaacctgac aagtctatct ctaagagccg ccagatttcc atgtgtgcag     2280

tattataagt tatcatggaa ctatatggtg gacgcagacc ttgagaacaa cctaaattat     2340

ggggagaatt ttaaaatgtt aaactgtaat ttgtatttaa aaagcattcg tagtaaaggt     2400

gcccaagaaa ttattttggc catttattgt tttgtccttt tctttaaaga actgtttttt     2460

tttcttttgt ttacttttag accaaagatt gggttctaga aaatgcactt ggtatactaa     2520

gtattaaaac aaacaaaaag gaaagttgtt tcagttggca acactgccca ttcaattgaa     2580

tcagaagggg acaaaattaa cgattgcctt cagtttgtgt tgtgtatatt ttgatgtatg     2640

tggtcactaa caggtcactt ttattttttc taaatgtagt gaaatgttaa tacctattgt     2700

acttataggt aaaccttgca aatatgtaac ctgtgttgcg caaatgccgc ataaatttga     2760

gtgattgtta atgttgtctt aaaatttctt gattgtgata ctgtggtcat atgcccgtgt     2820

ttgtcactta caaaaatgtt tactatgaac acacagaaat aaaaaatagg ctaaattcat     2880

atatatcttg atacttttgt ctcttttatt aagtagagct aattttttaa agaccaatca     2940

acttataggg aattcaaagg ctttttcagc caaactaaaa tttaaactgc tcctttaatt     3000

tgaactgact ctaaaaatga aaatagtatt tttccctttg tgaacaaatt ttacaaggag     3060

cagcctattt aataaacact agctttaaac aaagtatagg cttttcagct gatacctgta     3120

agtttctgtg gatatacagc aaaaagagat ataatttaat tttctgtgca tagctcttta     3180

ccctgtgttt atttccaaat ccattaatag aatgccattt atatattttg tttcaggtat     3240

attgttaata gagcttggca aattataaat aaatatatgt atatggttag atagaagtga     3300

ctataatgca cacatatgta atatatatag acacacagag cccttcagtt caggtacaat     3360

ttgcgctatg aatgctgcaa acatttttgt ttaaatattt gtatttatac tttctaagtc     3420

agcatttatt tttgtggctg tttacccaca atgaaagagt tctaataaag atgtgctgaa     3480

gttgcaatat a                                                          3491


<210>  11
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Asp Met Gly Asp Arg Lys Glu Val Lys Met Ile Pro Lys Ser Ser 
1               5                   10                  15      


Phe Ser Ile Asn Ser Leu Val Pro Glu Ala Val Gln Asn Asp Asn His 
            20                  25                  30          


His Ala Ser His Gly His His Asn Ser His His Pro Gln His His His 
        35                  40                  45              


His His His His His His His His Pro Pro Pro Pro Ala Pro Gln Pro 
    50                  55                  60                  


Pro Pro Pro Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Ala 
65                  70                  75                  80  


Pro Gln Pro Pro Gln Thr Arg Gly Ala Pro Ala Ala Asp Asp Asp Lys 
                85                  90                  95      


Gly Pro Gln Gln Leu Leu Leu Pro Pro Pro Pro Pro Pro Pro Pro Ala 
            100                 105                 110         


Ala Ala Leu Asp Gly Ala Lys Ala Asp Gly Leu Gly Gly Lys Gly Glu 
        115                 120                 125             


Pro Gly Gly Gly Pro Gly Glu Leu Ala Pro Val Gly Pro Asp Glu Lys 
    130                 135                 140                 


Glu Lys Gly Ala Gly Ala Gly Gly Glu Glu Lys Lys Gly Ala Gly Glu 
145                 150                 155                 160 


Gly Gly Lys Asp Gly Glu Gly Gly Lys Glu Gly Glu Lys Lys Asn Gly 
                165                 170                 175     


Lys Tyr Glu Lys Pro Pro Phe Ser Tyr Asn Ala Leu Ile Met Met Ala 
            180                 185                 190         


Ile Arg Gln Ser Pro Glu Lys Arg Leu Thr Leu Asn Gly Ile Tyr Glu 
        195                 200                 205             


Phe Ile Met Lys Asn Phe Pro Tyr Tyr Arg Glu Asn Lys Gln Gly Trp 
    210                 215                 220                 


Gln Asn Ser Ile Arg His Asn Leu Ser Leu Asn Lys Cys Phe Val Lys 
225                 230                 235                 240 


Val Pro Arg His Tyr Asp Asp Pro Gly Lys Gly Asn Tyr Trp Met Leu 
                245                 250                 255     


Asp Pro Ser Ser Asp Asp Val Phe Ile Gly Gly Thr Thr Gly Lys Leu 
            260                 265                 270         


Arg Arg Arg Ser Thr Thr Ser Arg Ala Lys Leu Ala Phe Lys Arg Gly 
        275                 280                 285             


Ala Arg Leu Thr Ser Thr Gly Leu Thr Phe Met Asp Arg Ala Gly Ser 
    290                 295                 300                 


Leu Tyr Trp Pro Met Ser Pro Phe Leu Ser Leu His His Pro Arg Ala 
305                 310                 315                 320 


Ser Ser Thr Leu Ser Tyr Asn Gly Thr Thr Ser Ala Tyr Pro Ser His 
                325                 330                 335     


Pro Met Pro Tyr Ser Ser Val Leu Thr Gln Asn Ser Leu Gly Asn Asn 
            340                 345                 350         


His Ser Phe Ser Thr Ala Asn Gly Leu Ser Val Asp Arg Leu Val Asn 
        355                 360                 365             


Gly Glu Ile Pro Tyr Ala Thr His His Leu Thr Ala Ala Ala Leu Ala 
    370                 375                 380                 


Ala Ser Val Pro Cys Gly Leu Ser Val Pro Cys Ser Gly Thr Tyr Ser 
385                 390                 395                 400 


Leu Asn Pro Cys Ser Val Asn Leu Leu Ala Gly Gln Thr Ser Tyr Phe 
                405                 410                 415     


Phe Pro His Val Pro His Pro Ser Met Thr Ser Gln Ser Ser Thr Ser 
            420                 425                 430         


Met Ser Ala Arg Ala Ala Ser Ser Ser Thr Ser Pro Gln Ala Pro Ser 
        435                 440                 445             


Thr Leu Pro Cys Glu Ser Leu Arg Pro Ser Leu Pro Ser Phe Thr Thr 
    450                 455                 460                 


Gly Leu Ser Gly Gly Leu Ser Asp Tyr Phe Thr His Gln Asn Gln Gly 
465                 470                 475                 480 


Ser Ser Ser Asn Pro Leu Ile His 
                485             


<210>  12
<211>  6046
<212>  DNA
<213>  Homo sapiens

<400>  12
acagtgccaa taccatgaag aggagctcag acagctctta ccacatgata caagagccgg       60

ctggtggaag agtggggacc agaaagagaa tttgctgaag aggagaagga aaaaaaaaac      120

accaaaaaaa aaaataaaaa aatccacaca cacaaaaaaa cctgcgcgtg aggggggagg      180

aaaagcaggg ccttttaaaa aggcaatcac aacaactttt gctgccagga tgcccttgct      240

ttggctgaga ggatttctgt tggcaagttg ctggattata gtgaggagtt cccccacccc      300

aggatccgag gggcacagcg cggcccccga ctgtccgtcc tgtgcgctgg ccgccctccc      360

aaaggatgta cccaactctc agccagagat ggtggaggcc gtcaagaagc acattttaaa      420

catgctgcac ttgaagaaga gacccgatgt cacccagccg gtacccaagg cggcgcttct      480

gaacgcgatc agaaagcttc atgtgggcaa agtcggggag aacgggtatg tggagataga      540

ggatgacatt ggaaggaggg cagaaatgaa tgaacttatg gagcagacct cggagatcat      600

cacgtttgcc gagtcaggaa cagccaggaa gacgctgcac ttcgagattt ccaaggaagg      660

cagtgacctg tcagtggtgg agcgtgcaga agtctggctc ttcctaaaag tccccaaggc      720

caacaggacc aggaccaaag tcaccatccg cctcttccag cagcagaagc acccgcaggg      780

cagcttggac acaggggaag aggccgagga agtgggctta aagggggaga ggagtgaact      840

gttgctctct gaaaaagtag tagacgctcg gaagagcacc tggcatgtct tccctgtctc      900

cagcagcatc cagcggttgc tggaccaggg caagagctcc ctggacgttc ggattgcctg      960

tgagcagtgc caggagagtg gcgccagctt ggttctcctg ggcaagaaga agaagaaaga     1020

agaggagggg gaagggaaaa agaagggcgg aggtgaaggt ggggcaggag cagatgagga     1080

aaaggagcag tcgcacagac ctttcctcat gctgcaggcc cggcagtctg aagaccaccc     1140

tcatcgccgg cgtcggcggg gcttggagtg tgatggcaag gtcaacatct gctgtaagaa     1200

acagttcttt gtcagtttca aggacatcgg ctggaatgac tggatcattg ctccctctgg     1260

ctatcatgcc aactactgcg agggtgagtg cccgagccat atagcaggca cgtccgggtc     1320

ctcactgtcc ttccactcaa cagtcatcaa ccactaccgc atgcggggcc atagcccctt     1380

tgccaacctc aaatcgtgct gtgtgcccac caagctgaga cccatgtcca tgttgtacta     1440

tgatgatggt caaaacatca tcaaaaagga cattcagaac atgatcgtgg aggagtgtgg     1500

gtgctcatag agttgcccag cccaggggga aagggagcaa gagttgtcca gagaagacag     1560

tggcaaaatg aagaaatttt taaggtttct gagttaacca gaaaaataga aattaaaaac     1620

aaaacaaaaa aaaaaacaaa aaaaaacaaa agtaaattaa aaacaaaacc tgatgaaaca     1680

gatgaaggaa gatgtggaaa aaatccttag ccagggctca gagatgaagc agtgaaagag     1740

acaggaattg ggagggaaag ggagaatggt gtacccttta tttcttctga aatcacactg     1800

atgacatcag ttgtttaaac ggggtattgt cctttccccc cttgaggttc ccttgtgagc     1860

cttgaatcaa ccaatctagt ctgcagtagt gtggactaga acaacccaaa tagcatctag     1920

aaagccatga gtttgaaagg gcccatcaca ggcactttcc tacccaatta cccaggtcat     1980

aaggtatgtc tgtgtgacac ttatctctgt gtatatcagc atacacacac acacacacac     2040

acacacacac acacacaggc atttccacac attacatata tacacatact ggtaaaagaa     2100

caatcgtgtg caggtggtca cacttccttt ttctgtacca cttttgcaac aaaacaaaac     2160

aaacaacatt aaaaaattga gaacaagtat ggaaagaatg aaagatcaag gaaaaaagaa     2220

taccaagtta catttcgtta aggtgcttat gatcttagaa ctatgcaacc taataggttt     2280

gaaactgttt acctgagaga gaacaaaaag agagactttt ttgtattgga agtaatctga     2340

ttaattttta ttttcttcaa ggagagatac ttgaaaggaa tatgtttgtc catctgttgg     2400

atccaaacat ttctatattt tgtaaatgtt gttgttgttt tttttttaat cgtttactat     2460

ttgcactaca atggtgtttg acctgtctaa tccttattta acaagtattt tctttggttg     2520

ggggtggggg tggggtttaa gagctgcact taatgtgagc tataaaagaa ctgctacagc     2580

acacaaaata gctattttta ttattataat tataattatt attattattt tgtaccttaa     2640

aaaatagaca catacaccaa agacatttgt gtgagccttt aaacagtctg tctgtggttg     2700

gtatcattca ccatcaatga gtcaggggtt gggattcaag gttgagtagt gtggattgtg     2760

ttcaggctta aaagacctga gaagtttggt ttttgactcc ttttacatcc atgaaacagg     2820

acatttcata ctggatgtac agtagttgta cactgttgga tatcaagttc aatcaaattc     2880

atggaactac atgcttgtat gtgtatatat acattgcttg tgcatatgca tatctgtatg     2940

tatatataca tgtattgtac catgtccata cacattttaa gcacttcagg ctgtcatttt     3000

ttaatgttct taaagcaatg aatgtttgtg tgcaaaacac agtattttta agaaggatag     3060

gctatagttt ttgcttttac tctgaactag gtgggcgcat ttcaaaaatt cggatgggaa     3120

aaagcctgga aattccagtg aatattcagc aaggccctct ttcattgtac agggatcaaa     3180

tttcctcctc ttttttgtgc cccctcccac ttctacaagt tatcccctgt ggggaaaaca     3240

ggatgataat caaaactctg ggctgatgtt tttccaactt agtgtctatt ggaatcaatc     3300

ttaaatcaga agctttttca gaaaaataat atttaggcca gaattagagt tgagtgtatt     3360

ttttaaaaat gattaaggct tggttgtgag aaatattacc tgtaccagct gggaaaaata     3420

atgtcatcac taactaaaag ataattaatt tgagagaaag tgttaagaga gggagagtaa     3480

ggaagagaac agttaagagg aggcagaggt gagggcagta gtaaaaatct ctaaaatttt     3540

aatttacagc caaaattctt catgtgtaaa tttgtattga ttcagatgca gaaatgaaaa     3600

aaaaacacct ttgttttata aatatcaaag tacatgctta aagccaagtt tttatctagt     3660

ttattctagt acttagcttg cctggaatag ctaataaatt attcatgtat gtgcttttga     3720

aaatccagag ccctattttt acacacttgt gtgaagttgg caaacatttt gaaaaatgga     3780

aaaaagtttc taataattgg gaacaattac attaattaat attttgtaaa atattgaagc     3840

ttttagccct atgtcaattt gtagattaaa ataaattaat tataggaaag gaagataaca     3900

gtgagaaacc aaacattaca aaaggtggtt tagctctcct tgaaaaatat actaagttgg     3960

tatactataa cacttggcta tatgtaggca atgtcactac tgggcaaata cacttactgt     4020

gttctagagg cagccctttc ttatgcagaa aatacaatac gcactgcatg agaagcttga     4080

gagtggattc taatccaggt ctgtcgacct tggatatcat gcatgtggga aggtgggtgt     4140

ggtgagaaaa gttttaaggc aagagtagat ggccatgttc aactttacaa aatttcttgg     4200

aaaactggca gtattttgaa ctgcatcttc tttggtaccg gaacctgcag aaacagtgtg     4260

agaaattaag tcctggttca ctgcgcagta gcaaagatgg tcaaggccat ggaaaaagca     4320

gaaatttacc aagaaagctg atacccatgt atagttccca ctcatctcaa atacatctgc     4380

tatcttttta agctaagtcc tagacatatc ggggataaca tgggggttga ttagtgacca     4440

cagttatcag aagcagagaa atgtaattcc atattttatt tgaaacttat tccatatttt     4500

aattggatat tgagtgattg ggttatcaaa cacccacaaa ctttaatttt gttaaattta     4560

tatggctttg aaatagaagt ataagttgct accatttttt gataacattg aaagatagta     4620

ttttaccatc tttaatcatc ttggaaaata caagtcctgt gaacaaccac tctttcacct     4680

agcagcatga ggccaaaagt aaaggcttta aattataaca tatgggattc ttagtagtat     4740

gtttttttct tgaaactcag tggctctatc taaccttact atctcctcac tctttctcta     4800

agactaaact ctaggctctt aaaaatctgc ccacaccaat cttagaagct ctgaaaagaa     4860

tttgtcttta aatatctttt aatagtaaca tgtattttat ggaccaaatt gacattttcg     4920

actatttttt ccaaaaaagt caggtgaatt tcagcacact gagttgggaa tttcttatcc     4980

cagaagacca accaatttca tatttattta agattgattc catactccgt tttcaaggag     5040

aatccctgca gtctccttaa aggtagaaca aatactttct attttttttt caccattgtg     5100

ggattggact ttaagaggtg actctaaaaa aacagagaac aaatatgtct cagttgtatt     5160

aagcacggac ccatattatc atattcactt aaaaaaatga tttcctgtgc accttttggc     5220

aacttctctt ttcaatgtag ggaaaaactt agtcaccctg aaaacccaca aaataaataa     5280

aacttgtaga tgtgggcaga aggtttgggg gtggacattg tatgtgttta aattaaaccc     5340

tgtatcactg agaagctgtt gtatgggtca gagaaaatga atgcttagaa gctgttcaca     5400

tcttcaagag cagaagcaaa ccacatgtct cagctatatt attatttatt ttttatgcat     5460

aaagtgaatc atttcttctg tattaatttc caaagggttt taccctctat ttaaatgctt     5520

tgaaaaacag tgcattgaca atgggttgat atttttcttt aaaagaaaaa tataattatg     5580

aaagccaaga taatctgaag cctgttttat tttaaaactt tttatgttct gtggttgatg     5640

ttgtttgttt gtttgtttct attttgttgg ttttttactt tgttttttgt tttgttttgt     5700

tttgttttgc atactacatg cagttcttta accaatgtct gtttggctaa tgtaattaaa     5760

gttgttaatt tatatgagtg catttcaact atgtcaatgg tttcttaata tttattgtgt     5820

agaagtactg gtaatttttt tatttacaat atgtttaaag agataacagt ttgatatgtt     5880

ttcatgtgtt tatagcagaa gttatttatt tctatggcat tccagcggat attttggtgt     5940

ttgcgaggca tgcagtcaat attttgtaca gttagtggac agtattcagc aacgcctgat     6000

agcttctttg gccttatgtt aaataaaaag acctgtttgg gatgta                    6046


<210>  13
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  14
<211>  2549
<212>  DNA
<213>  Homo sapiens

<400>  14
gtccattgaa tcgcgcgggc ggccggcggc gagcgcgggg ctgcgccggg atcgctgcgc       60

cctccgccgc tggcctctgc gacgcgcgcc gctcgcccga gccacccgcc gccgcgccgg      120

ctccccgcgc cgctgcgctc ctcgccccgc gcctgccccc aggatggtcc gcgcgaggca      180

ccagccgggt gggctttgcc tcctgctgct gctgctctgc cagttcatgg aggaccgcag      240

tgcccaggct gggaactgct ggctccgtca agcgaagaac ggccgctgcc aggtcctgta      300

caagaccgaa ctgagcaagg aggagtgctg cagcaccggc cggctgagca cctcgtggac      360

cgaggaggac gtgaatgaca acacactctt caagtggatg attttcaacg ggggcgcccc      420

caactgcatc ccctgtaaag aaacgtgtga gaacgtggac tgtggacctg ggaaaaaatg      480

ccgaatgaac aagaagaaca aaccccgctg cgtctgcgcc ccggattgtt ccaacatcac      540

ctggaagggt ccagtctgcg ggctggatgg gaaaacctac cgcaatgaat gtgcactcct      600

aaaggcaaga tgtaaagagc agccagaact ggaagtccag taccaaggca gatgtaaaaa      660

gacttgtcgg gatgttttct gtccaggcag ctccacatgt gtggtggacc agaccaataa      720

tgcctactgt gtgacctgta atcggatttg cccagagcct gcttcctctg agcaatatct      780

ctgtgggaat gatggagtca cctactccag tgcctgccac ctgagaaagg ctacctgcct      840

gctgggcaga tctattggat tagcctatga gggaaagtgt atcaaagcaa agtcctgtga      900

agatatccag tgcactggtg ggaaaaaatg tttatgggat ttcaaggttg ggagaggccg      960

gtgttccctc tgtgatgagc tgtgccctga cagtaagtcg gatgagcctg tctgtgccag     1020

tgacaatgcc acttatgcca gcgagtgtgc catgaaggaa gctgcctgct cctcaggtgt     1080

gctactggaa gtaaagcact ccggatcttg caactgaatc tgcccgtaaa acctgagcca     1140

ttgattcttc agaactttct gcagtttttg acttcataga ttatgcttta aaaaaatttt     1200

tttaacttat tgcataacag cagatgccaa aaacaaaaaa agcatctcac tgcaagtcac     1260

ataaaaatgc aacgctgtaa tatggctgta tcagagggct ttgaaaacat acactgagct     1320

gcttctgcgc tgttgttgtc cgtatttaaa caacagctcc cctgtattcc cccatctagc     1380

catttcggaa gacaccgagg aagaggagga agatgaagac caggactaca gctttcctat     1440

atcttctatt ctagagtggt aaactctcta taagtgttca gtgttgacat agcctttgtg     1500

caaaaaaaaa aaaaaaaaaa aagaaaaaga aaaaaagaaa aatatattgt ccatactgta     1560

aataagtgta tgcttattta tttgggggga aaactataca ttaaaggacc tttgtcctaa     1620

agctctctcc caggccacct tgttactcat tggacacgga gaggcattca ttgtgaggtc     1680

tactggatga ggcccatagt tgagacttgt agacatttat ttatactgtg tcatgtttta     1740

taatttatac ataaaatgtc tggttgactg tataccttgt ttttgaagaa atttattcgt     1800

gaaaggaaga gcagttgtta tttattgtga ggtctcttgc ttgtaaagta aaagcttttt     1860

ttccttgtaa accatttaag tccattcctt actattcact cactcatctg tctcccttca     1920

tttcactgtt agactctttt ccactttcaa caaacttgca tgtcagtttc tgtcatgttt     1980

atttattgga ttctctgctg cctgatctgt acatacatga tccctcgggt tttgtttaca     2040

aggaaccttg actgaccaaa aggcattata actctgactc aaatacaagg tacagaagat     2100

aagcatcttt gaggaaactc ctacttcagt tcttttgtta tgatgaagac atttgtgaga     2160

gaggagatga ttagaattct agtaatgtac ttttaagatg ttacagatac aaagaaatga     2220

tgtgggtgtc aggagactaa aggatgttga aggctacaca ttcaaccttt tgttaggtgt     2280

ttcctttaag ctactcagct gtacctttta aattagttct ttttcaacca gtatatcact     2340

aaaagttata tcaaagcttt atcagttcaa gtttcttgct tttcataata cttttttctg     2400

atgcaatttt atattttcaa acatggcaag ttaaaatata aattcattta aatatatagt     2460

tttgtacttt tctaccatgt aaatgtgcaa tgtatataaa agttataatg tgtatttgta     2520

aataaatgat gagtgaaaaa ataaaaaaa                                       2549


<210>  15
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val Arg Ala Arg His Gln Pro Gly Gly Leu Cys Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Cys Gln Phe Met Glu Asp Arg Ser Ala Gln Ala Gly Asn Cys 
            20                  25                  30          


Trp Leu Arg Gln Ala Lys Asn Gly Arg Cys Gln Val Leu Tyr Lys Thr 
        35                  40                  45              


Glu Leu Ser Lys Glu Glu Cys Cys Ser Thr Gly Arg Leu Ser Thr Ser 
    50                  55                  60                  


Trp Thr Glu Glu Asp Val Asn Asp Asn Thr Leu Phe Lys Trp Met Ile 
65                  70                  75                  80  


Phe Asn Gly Gly Ala Pro Asn Cys Ile Pro Cys Lys Glu Thr Cys Glu 
                85                  90                  95      


Asn Val Asp Cys Gly Pro Gly Lys Lys Cys Arg Met Asn Lys Lys Asn 
            100                 105                 110         


Lys Pro Arg Cys Val Cys Ala Pro Asp Cys Ser Asn Ile Thr Trp Lys 
        115                 120                 125             


Gly Pro Val Cys Gly Leu Asp Gly Lys Thr Tyr Arg Asn Glu Cys Ala 
    130                 135                 140                 


Leu Leu Lys Ala Arg Cys Lys Glu Gln Pro Glu Leu Glu Val Gln Tyr 
145                 150                 155                 160 


Gln Gly Arg Cys Lys Lys Thr Cys Arg Asp Val Phe Cys Pro Gly Ser 
                165                 170                 175     


Ser Thr Cys Val Val Asp Gln Thr Asn Asn Ala Tyr Cys Val Thr Cys 
            180                 185                 190         


Asn Arg Ile Cys Pro Glu Pro Ala Ser Ser Glu Gln Tyr Leu Cys Gly 
        195                 200                 205             


Asn Asp Gly Val Thr Tyr Ser Ser Ala Cys His Leu Arg Lys Ala Thr 
    210                 215                 220                 


Cys Leu Leu Gly Arg Ser Ile Gly Leu Ala Tyr Glu Gly Lys Cys Ile 
225                 230                 235                 240 


Lys Ala Lys Ser Cys Glu Asp Ile Gln Cys Thr Gly Gly Lys Lys Cys 
                245                 250                 255     


Leu Trp Asp Phe Lys Val Gly Arg Gly Arg Cys Ser Leu Cys Asp Glu 
            260                 265                 270         


Leu Cys Pro Asp Ser Lys Ser Asp Glu Pro Val Cys Ala Ser Asp Asn 
        275                 280                 285             


Ala Thr Tyr Ala Ser Glu Cys Ala Met Lys Glu Ala Ala Cys Ser Ser 
    290                 295                 300                 


Gly Val Leu Leu Glu Val Lys His Ser Gly Ser Cys Asn 
305                 310                 315         


<210>  16
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
ccacgttctg cttcactctc cccatctccc ccccctcccc acccccaatt ttgtatttat       60

ttatttttta attattttgt gcagcgatgg gggcgggggg gggggggggg cgcgcgccag      120

gcggggcggg gcggggcgag gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca      180

atcagagcgg cgcgctccga aagtttcctt ttatggcgag gcggcggcgg cggcggccct      240

ataaaaagcg aagcgcgcgg cgggcgggag                                       270


<210>  17
<211>  280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac                            280


<210>  18
<211>  1629
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
tttggaggcc gccctgtccc ccataacctg cccacctctc tgccccattc ccacagctca       60

ctgcattttg tccctgctgc cagtcgtgtg ccatgggctc tcctgtgctc ccccggggtc      120

tcatttcccc atccgtgtag ggctgacgcc actggccccg cccagcctgg gaggatggag      180

aggggggact tgaggagtgg ccagtactgg gtttcggcag caggtgcaaa tcccaggtgg      240

ggactgtgtt ccagggactc ctggactcct gttaggccag caggctaagg ggcagacggc      300

atcctggggt cttcctggga cagggtcgtc gggtctgagg ggacccaggc cctagcagaa      360

gctgactcct gtcacggtca cttcccagcg gtgctcagcc cgcctgacgg aagcagctgg      420

gcagtggggc ctgtgaccag caggcggcgc tggcgagcta tagcgcccct ttgggccccc      480

accccacctt ctgggcagct tccctgcaga caccccagtt atgggggcta gggacccaaa      540

agagacatcc ttctgccacc cagagctgcc ctggcgaggt gcactatggg gccgccgaca      600

gctgcgtggc tgccgagggc ggaaaggaga aactgtcatg tcccgatagg gccgcgcgag      660

gtctccatcc tcgacaacgc taataacaaa gacgtgtgct cctctttgct tggttccccc      720

cactccttta aatcacagat ttcacttcag tttatctgtg tcgctgtcac acgtggggtg      780

gctcccagtc agctggtttg gcaaagtttc tggatgatta cggaataaca tgtgtcccca      840

acccgcagag caggttgtgg gggcaatgtt gcattgacca gcgtcagaga acacacatca      900

gaggcaaggg tgggtgtgca ggagggagaa ggcgcagaag gcagggcttt agctcagcac      960

tctccctcct gccatgctct gcctgaccgt tccctctctg agtcccaaac agccaggtag     1020

aggaggaaga aatggggctg agaccccagc acatcagtga ttaagtcagg atcaggtgcg     1080

gtttcctgct caggtgctga gacagcaggc ggtgtcctgc aaacaacagg aggcacctga     1140

agctagcctg gggggcccac gcccaggtgc ggtgcattca gcagcacagc cagagacaga     1200

ccccaatgac cccgcctccc tgtcggcagc cagtgctctg cacagagccc tgagcagcct     1260

ctggacatta gtcccagccc cagcacggcc cgtcccccac gctgatgtca ccgcacccag     1320

accttggagg ccccctccgg ctccgcctcc tgggagaagg ctctggagtg aggaggggag     1380

ggcagcagtg ctggctggac agctgctctg ggcaggagag agagggagag acaagagaca     1440

cacacagaga gacggcgagg aagggaaaga cccagaggga cgcctagaac gagacttgga     1500

gccagacaga ggaagagggg acgtgtgttt gcagactggc tgggcccgtg acccagcttc     1560

ctgagtcctc cgtgcaggtg gcagctgtac caggctggca ggtcactgag agtgggcagc     1620

tgggcccca                                                             1629


<210>  19
<211>  528
<212>  DNA
<213>  Homo Sapiens

<400>  19
atctctctcg ggtggagtct tctgacagct ggtgcgcctg cccgggaaca tcctcctgga       60

ctcaatcatg gcttgtggtc tggtcgccag caacctgaat ctcaaacctg gagagtgcct      120

tcgagtgcga ggcgaggtgg ctcctgacgc taagagcttc gtgctgaacc tgggcaaaga      180

cagcaacaac ctgtgcctgc acttcaaccc tcgcttcaac gcccacggcg acgccaacac      240

catcgtgtgc aacagcaagg acggcggggc ctgggggacc gagcagcggg aggctgtctt      300

tcccttccag cctggaagtg ttgcagaggt gtgcatcacc ttcgaccagg ccaacctgac      360

cgtcaagctg ccagatggat acgaattcaa gttccccaac cgcctcaacc tggaggccat      420

caactacatg gcagctgacg gtgacttcaa gatcaaatgt gtggcctttg actgaaatca      480

gccagcccat ggcccccaat aaaggcagct gcctctgctc cctctgaa                   528


<210>  20
<211>  135
<212>  PRT
<213>  Homo Sapiens

<400>  20

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  21
<211>  943
<212>  DNA
<213>  Homo Sapiens

<400>  21
gcccgcagca cctcctcgcc agcagccgtc cggagccagc caacgagcgg aaaatggcag       60

acaatttttc gctccatgat gcgttatctg ggtctggaaa cccaaaccct caaggatggc      120

ctggcgcatg ggggaaccag cctgctgggg cagggggcta cccaggggct tcctatcctg      180

gggcctaccc cgggcaggca cccccagggg cttatcctgg acaggcacct ccaggcgcct      240

accctggagc acctggagct tatcccggag cacctgcacc tggagtctac ccagggccac      300

ccagcggccc tggggcctac ccatcttctg gacagccaag tgccaccgga gcctaccctg      360

ccactggccc ctatggcgcc cctgctgggc cactgattgt gccttataac ctgcctttgc      420

ctgggggagt ggtgcctcgc atgctgataa caattctggg cacggtgaag cccaatgcaa      480

acagaattgc tttagatttc caaagaggga atgatgttgc cttccacttt aacccacgct      540

tcaatgagaa caacaggaga gtcattgttt gcaatacaaa gctggataat aactggggaa      600

gggaagaaag acagtcggtt ttcccatttg aaagtgggaa accattcaaa atacaagtac      660

tggttgaacc tgaccacttc aaggttgcag tgaatgatgc tcacttgttg cagtacaatc      720

atcgggttaa aaaactcaat gaaatcagca aactgggaat ttctggtgac atagacctca      780

ccagtgcttc atataccatg atataatctg aaaggggcag attaaaaaaa aaaaaagaat      840

ctaaacctta catgtgtaaa ggtttcatgt tcactgtgag tgaaaatttt tacattcatc      900

aatatccctc ttgtaagtca tctacttaat aaatattaca gtg                        943


<210>  22
<211>  250
<212>  PRT
<213>  Homo Sapiens

<400>  22

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


