                         SEQUENCE LISTING

<110>  RAMEA LLC
       Extend Biosciences Inc.
       Barron, Russell  J
       Soliman, Tarik   J
       Hall, Daniel  B
 
<120>  Extended Half-life G-CSF and GM-CSF Vitamin D Conjugates

<130>  0331.0001001

<140>  PCT/US20/56210
<141>  2020-10-18

<150>  62923498
<151>  2019-10-19

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  2374
<212>  DNA
<213>  Homo sapiens

<400>  1
agcccggagc ctgcagccca gccccaccca gacccatggc tggacctgcc acccagagcc       60

ccatgaagct gatgggtgag tgtcttggcc caggatggga gagccgcctg ccctggcatg      120

ggagggaggc tggtgtgaca gaggggctgg ggatccccgt tctgggaatg gggattaaag      180

gcacccagtg tccccgagag ggcctcaggt ggtagggaac agcatgtctc ctgagcccgc      240

tctgtcccca gccctgcagc tgctgctgtg gcacagtgca ctctggacag tgcaggaagc      300

cacccccctg ggccctgcca gctccctgcc ccagagcttc ctgctcaagt gcttagagca      360

agtgaggaag atccagggcg atggcgcagc gctccaggag aagctggtga gtgaggtggg      420

tgagagggct gtggagggaa gcccggtggg gagagctaag ggggatggaa ctgcagggcc      480

aacatcctct ggaagggacg tgggagaata ttaggagcag tggagctggg gaaggctggg      540

aagggacttg gggaggagga ccttggtggg gacagtgctc gggagggctg gctgggatgg      600

gagtggaggc attacattca ggagaaaggg caagggcccc tgtgagatca gagagtgggg      660

gtgcagggca gagaggaact gaacagcctg gcaggacatg gagggagggg aaagaccaga      720

gagtcgggga ggacccggga aggagcggcg acccggccat ggcgagtctc actcagcatc      780

cttccatccc cagtgtgcca cctacaagct gtgccacccc gaggagctgg tgctgctcgg      840

acactctctg ggcatcccct gggctcccct gagcagctgc cccagccagg ccctgcagct      900

ggtgagtgtc aggaaaggat aaggctaatg aggaggggga aggagaggag gaacacccat      960

gggctccccc atgtctccag gttccaagct gggggcctga cgtatctcag gcagcacccc     1020

ctaactcttc cgctctgtct cacaggcagg ctgcttgagc caactccata gcggcctttt     1080

cctctaccag gggctcctgc aggccctgga agggatctcc cccgagttgg gtcccacctt     1140

ggacacactg cagctggacg tcgccgactt tgccaccacc atctggcagc aggtgagcct     1200

tgttgggcag ggtggccaag gtcgtgctgg cattctgggc accacagcca ggcctgtgta     1260

tgggccctgt ccatgctgtc acccccagca tttcctcatt tgtaataacg cccactcaga     1320

agggcccaac cactgatcac agctttcccc cacagatgga agaactggga atggcccctg     1380

ccctgcagcc cacccagggt gccatgccgg ccttcgcctc tgctttccag cgccgggcag     1440

gaggggtcct ggttgcctcc catctgcaga gcttcctgga ggtgtcgtac cgcgttctac     1500

gccaccttgc ccagccctga gccaagccct ccccatccca tgtatttatc tctatttaat     1560

atttatgtct atttaagcct catatttaaa gacagggaag agcagaacgg agccccaggc     1620

ctctgtgtcc ttccctgcat ttctgagttt cattctcctg cctgtagcag tgagaaaaag     1680

ctcctgtcct cccatcccct ggactgggag gtagataggt aaataccaag tatttattac     1740

tatgactgct ccccagccct ggctctgcaa tgggcactgg gatgagccgc tgtgagcccc     1800

tggtcctgag ggtccccacc tgggaccctt gagagtatca ggtctcccac gtgggagaca     1860

agaaatccct gtttaatatt taaacagcag tgttccccat ctgggtcctt gcacccctca     1920

ctctggcctc agccgactgc acagcggccc ctgcatcccc ttggctgtga ggcccctgga     1980

caagcagagg tggccagagc tgggaggcat ggccctgggg tcccacgaat ttgctgggga     2040

atctcgtttt tcttcttaag acttttggga catggtttga ctcccgaaca tcaccgacgc     2100

gtctcctgtt tttctgggtg gcctcgggac acctgccctg cccccacgag ggtcaggact     2160

gtgactcttt ttagggccag gcaggtgcct ggacatttgc cttgctggac ggggactggg     2220

gatgtgggag ggagcagaca ggaggaatca tgtcaggcct gtgtgtgaaa ggaagctcca     2280

ctgtcaccct ccacctcttc accccccact caccagtgtc ccctccactg tcacattgta     2340

actgaacttc aggataataa agtgtttgcc tcca                                 2374


<210>  2
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
            100                 105                 110         


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


<210>  3
<211>  3008
<212>  DNA
<213>  Homo sapiens

<400>  3
agagctcggg gagagaagct ggactgcagc tggtttcagg aacttctctt gacgagaaga       60

gagaccaagg aggccaagca ggggctgggc cagaggtgcc aacatgggga aactgaggct      120

cggctcggaa aggtgaagta acttgtccaa gatcacaaag ctggtgaaca tcaagttggt      180

gctatggcaa ggctgggaaa ctgcagcctg acttgggctg ccctgatcat cctgctgctc      240

cccggaagtc tggaggagtg cgggcacatc agtgtctcag cccccatcgt ccacctgggg      300

gatcccatca cagcctcctg catcatcaag cagaactgca gccatctgga cccggagcca      360

cagattctgt ggagactggg agcagagctt cagcccgggg gcaggcagca gcgtctgtct      420

gatgggaccc aggaatctat catcaccctg ccccacctca accacactca ggcctttctc      480

tcctgctgcc tgaactgggg caacagcctg cagatcctgg accaggttga gctgcgcgca      540

ggctaccctc cagccatacc ccacaacctc tcctgcctca tgaacctcac aaccagcagc      600

ctcatctgcc agtgggagcc aggacctgag acccacctac ccaccagctt cactctgaag      660

agtttcaaga gccggggcaa ctgtcagacc caaggggact ccatcctgga ctgcgtgccc      720

aaggacgggc agagccactg ctgcatccca cgcaaacacc tgctgttgta ccagaatatg      780

ggcatctggg tgcaggcaga gaatgcgctg gggaccagca tgtccccaca actgtgtctt      840

gatcccatgg atgttgtgaa actggagccc cccatgctgc ggaccatgga ccccagccct      900

gaagcggccc ctccccaggc aggctgccta cagctgtgct gggagccatg gcagccaggc      960

ctgcacataa atcagaagtg tgagctgcgc cacaagccgc agcgtggaga agccagctgg     1020

gcactggtgg gccccctccc cttggaggcc cttcagtatg agctctgcgg gctcctccca     1080

gccacggcct acaccctgca gatacgctgc atccgctggc ccctgcctgg ccactggagc     1140

gactggagcc ccagcctgga gctgagaact accgaacggg cccccactgt cagactggac     1200

acatggtggc ggcagaggca gctggacccc aggacagtgc agctgttctg gaagccagtg     1260

cccctggagg aagacagcgg acggatccaa ggttatgtgg tttcttggag accctcaggc     1320

caggctgggg ccatcctgcc cctctgcaac accacagagc tcagctgcac cttccacctg     1380

ccttcagaag cccaggaggt ggcccttgtg gcctataact cagccgggac ctctcgtccc     1440

actccggtgg tcttctcaga aagcagaggc ccagctctga ccagactcca tgccatggcc     1500

cgagaccctc acagcctctg ggtaggctgg gagcccccca atccatggcc tcagggctat     1560

gtgattgagt ggggcctggg cccccccagc gcgagcaata gcaacaagac ctggaggatg     1620

gaacagaatg ggagagccac ggggtttctg ctgaaggaga acatcaggcc ctttcagctc     1680

tatgagatca tcgtgactcc cttgtaccag gacaccatgg gaccctccca gcatgtctat     1740

gcctactctc aagaaatggc tccctcccat gccccagagc tgcatctaaa gcacattggc     1800

aagacctggg cacagctgga gtgggtgcct gagccccctg agctggggaa gagccccctt     1860

acccactaca ccatcttctg gaccaacgct cagaaccagt ccttctccgc catcctgaat     1920

gcctcctccc gtggctttgt cctccatggc ctggagcccg ccagtctgta tcacatccac     1980

ctcatggctg ccagccaggc tggggccacc aacagtacag tcctcaccct gatgaccttg     2040

accccagagg ggtcggagct acacatcatc ctgggcctgt tcggcctcct gctgttgctc     2100

acctgcctct gtggaactgc ctggctctgt tgcagcccca acaggaagaa tcccctctgg     2160

ccaagtgtcc cagacccagc tcacagcagc ctgggctcct gggtgcccac aatcatggag     2220

gaggatgcct tccagctgcc cggccttggc acgccaccca tcaccaagct cacagtgctg     2280

gaggaggatg aaaagaagcc ggtgccctgg gagtcccata acagctcaga gacctgtggc     2340

ctccccactc tggtccagac ctatgtgctc cagggggacc caagagcagt ttccacccag     2400

ccccaatccc agtctggcac cagcgatcag gtcctttatg ggcagctgct gggcagcccc     2460

acaagcccag ggccagggca ctatctccgc tgtgactcca ctcagcccct cttggcgggc     2520

ctcaccccca gccccaagtc ctatgagaac ctctggttcc aggccagccc cttggggacc     2580

ctggtaaccc cagccccaag ccaggaggac gactgtgtct ttgggccact gctcaacttc     2640

cccctcctgc aggggatccg ggtccatggg atggaggcgc tggggagctt ctagggcttc     2700

ctggggttcc cttcttgggc ctgcctctta aaggcctgag ctagctggag aagaggggag     2760

ggtccataag cccatgacta aaaactaccc cagcccaggc tctcaccatc tccagtcacc     2820

agcatctccc tctcctccca atctccatag gctgggcctc ccaggcgatc tgcatacttt     2880

aaggaccaga tcatgctcca tccagcccca cccaatggcc ttttgtgctt gtttcctata     2940

acttcagtat tgtaaactag tttttggttt gcagtttttg ttgttgttta tagacactct     3000

tgggtgta                                                              3008


<210>  4
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
        675                 680                 685             


Gly Thr Pro Pro Ile Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys 
    690                 695                 700                 


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu 
705                 710                 715                 720 


Pro Thr Leu Val Gln Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
                725                 730                 735     


Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr 
            740                 745                 750         


Gly Gln Leu Leu Gly Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu 
        755                 760                 765             


Arg Cys Asp Ser Thr Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro 
    770                 775                 780                 


Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu 
785                 790                 795                 800 


Val Thr Pro Ala Pro Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu 
                805                 810                 815     


Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg Val His Gly Met Glu Ala 
            820                 825                 830         


Leu Gly Ser Phe 
        835     


<210>  5
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  5
aaaaaacagc ccggagcctg cagcccagcc ccacccagac ccatggctgg acctgccacc       60

cagagcccca tgaagctgat ggccctgcag ctgctgctgt ggcacagtgc actctggaca      120

gtgcaggaag ccacccccct gggccctgcc agctccctgc cccagagctt cctgctcaag      180

tgcttagagc aagtgaggaa gatccagggc gatggcgcag cgctccagga gaagctgtgt      240

gccacctaca agctgtgcca ccccgaggag ctggtgctgc tcggacactc tctgggcatc      300

ccctgggctc ccctgagcag ctgccccagc caggccctgc agctggcagg ctgcttgagc      360

caactccata gcggcctttt cctctaccag gggctcctgc aggccctgga agggatctcc      420

cccgagttgg gtcccacctt ggacacactg cagctggacg tcgccgactt tgccaccacc      480

atctggcagc agatggaaga actgggaatg gcccctgccc tgcagcccac ccagggtgcc      540

atgccggcct tcgcctctgc tttccagcgc cgggcaggag gggtcctagt tgcctcccat      600

ctgcagagct tcctggaggt gtcgtaccgc gttctacgcc accttgccca gccctgagcc      660


<210>  6
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 
65                  70                  75                  80  


Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 
                85                  90                  95      


Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser Gly Leu 
            100                 105                 110         


Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser Pro Glu 
        115                 120                 125             


Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp Phe Ala 
    130                 135                 140                 


Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro Ala Leu 
145                 150                 155                 160 


Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gln Arg 
                165                 170                 175     


Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe Leu Glu 
            180                 185                 190         


Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 


<210>  7
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  7
atggctggac ctgccaccca gagccccatg aagctgatgg ccctgcagct gctgctgtgg       60

cacagtgcac tctggacagt gcaggaagcc acccccctgg gccctgccag ctccctgccc      120

cagagcttcc tgctcaagtg cttagagcaa gtgaggaaga tccagggcga tggcgcagcg      180

ctccaggaga agctggtgag tgagtgtgcc acctacaagc tgtgccaccc cgaggagctg      240

gtgctgctcg gacactctct gggcatcccc tgggctcccc tgagcagctg ccccagccag      300

gccctgcagc tggcaggctg cttgagccaa ctccatagcg gccttttcct ctaccagggg      360

ctcctgcagg ccctggaagg gatctccccc gagttgggtc ccaccttgga cacactgcag      420

ctggacgtcg ccgactttgc caccaccatc tggcagcaga tggaagaact gggaatggcc      480

cctgccctgc agcccaccca gggtgccatg ccggccttcg cctctgcttt ccagcgccgg      540

gcaggagggg tcctggttgc ctcccatctg cagagcttcc tggaggtgtc gtaccgcgtt      600

ctacgccacc ttgcccagcc ctga                                             624


<210>  8
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Gly Pro Ala Thr Gln Ser Pro Met Lys Leu Met Ala Leu Gln 
1               5                   10                  15      


Leu Leu Leu Trp His Ser Ala Leu Trp Thr Val Gln Glu Ala Thr Pro 
            20                  25                  30          


Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys Cys Leu 
        35                  40                  45              


Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln Glu Lys 
    50                  55                  60                  


Leu Val Ser Glu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
65                  70                  75                  80  


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
                85                  90                  95      


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
            100                 105                 110         


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
        115                 120                 125             


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
    130                 135                 140                 


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
145                 150                 155                 160 


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
                165                 170                 175     


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
            180                 185                 190         


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
        195                 200                 205         


<210>  9
<211>  3194
<212>  DNA
<213>  Homo sapiens

<400>  9
aagcttgctg agagtggctg cagtctcgct gctggatgtg cacatggtgg tcattccctc       60

tgctcacagg ggcaggggtc cccccttact ggactcaggt tgccccctgc tccaggtcct      120

gggtgggagc ccatgtgaac tgtcagtggg gcaggtctgt gagagctccc ctcacactca      180

agtctctcac agtggccaga gaagaggaag gctggagtca gaatgaggca ccagggcggg      240

catagcctgc ccaaaggccc ctgggattac aggcaggatg gggagcccta tctaagtgtc      300

tcccacgccc caccccagcc attccaggcc aggaagtcca aactgtgccc ctcagaggga      360

gggggcagcc tcaggcccat tcagactgcc cagggagggc tggagagccc tcaggaaggc      420

gggtgggtgg gctgtcggtt cttggaaagg ttcattaatg aaaaccccca agcctgacca      480

cctagggaaa aggctcaccg ttcccatgtg tggctgataa gggccaggag attccacagt      540

tcaggtagtt cccccgcctc cctggcattt tgtggtcacc attaatcatt tcctctgtgt      600

atttaagagc tcttttgcca gtgagcccag tacacagaga gaaaggctaa agttctctgg      660

aggatgtggc tgcagagcct gctgctcttg ggcactgtgg cctgcagcat ctctgcaccc      720

gcccgctcgc ccagccccag cacgcagccc tgggagcatg tgaatgccat ccaggaggcc      780

cggcgtctcc tgaacctgag tagagacact gctgctgaga tggtaagtga gagaatgtgg      840

gcctgtgcct aggccaccca gctggcccct gactggccac gcctgtcagc ttgataacat      900

gacattttcc ttttctacag aatgaaacag tagaagtcat ctcagaaatg tttgacctcc      960

aggtaagatg cttctctctg acatagcttt ccagaagccc ctgccctggg gtggaggtgg     1020

ggactccatt ttagatggca ccacacaggg ttgtccactt tctctccagt cagctggctg     1080

caggaggagg gggtagcaac tgggtgctca agaggctgct ggccgtgccc ctatggcagt     1140

cacatgagct cctttatcag ctgagcggcc atgggcagac ctagcattca atggccagga     1200

gtcaccaggg gacaggtggt aaagtggggg tcacttcatg agacaggagc tgtgggtttg     1260

gggcgctcac tgtgccccga gaccaagtcc tgttgagaca gtgctgacta cagagaggca     1320

cagaggggtt tcaggaacaa cccttgccca cccagcaggt ccaggtgagg ccccaccccc     1380

ctctccctga atgatggggt gagagtcacc tccttcccta aggctgggct cctctccagg     1440

tgccgctgag ggtggcctgg gcggggcagt gagaagggca ggttcgtgcc tgccatggac     1500

agggcagggt ctatgactgg acccacgctg tgcccctccc aagccctact cctgggggct     1560

gggggcagca gcaaaaagga gtggtggaga gttcttgtac cactgtgggc acttggccac     1620

tgctcaccga cgaacgacat tttccacagg agccgacctg cctacagacc cgcctggagc     1680

tgtacaagca gggcctgcgg ggcagcctca ccaagctcaa gggccccttg accatgatgg     1740

ccagccacta caagcagcac tgccctccaa ccccggtgag tgcctacggc agggcctcca     1800

gcaggaatgt cttaatctag ggggtggggt cgacatgggg agagatctat ggctgtggct     1860

gttcaggacc ccagggggtt tctgtgccaa cagttatgta atgattagcc ctccagagag     1920

gaggcagaca gcccatttca tcccaaggag tcagagccac agagcgctga agcccacagt     1980

gctccccagc aggagctgct cctatcctgg tcattattgt cattacggtt aatgaggtca     2040

gaggtgaggg caaacccaag gaaacttggg gcctgcccaa ggcccagagg aagtgcccag     2100

gcccaagtgc caccttctgg caggactttc ctctggcccc acatggggtg cttgaattgc     2160

agaggatcaa ggaagggagg ctacttggaa tggacaagga cctcaggcac tccttctgcg     2220

ggaagggagc aaagtttgtg gccttgactc cactccttct gggtgcccag agacgacctc     2280

agcccagctg ccctgctctg ccctgggacc aaaaaggcag gcgtttgact gcccagaagg     2340

ccaacctcag gctggcactt aagtcaggcc cttgactctg gctgccactg gcagagctat     2400

gcactccttg gggaacacgt gggtggcagc agcgtcacct gacccaggtc agtgggtgtg     2460

tcctggagtg ggcctcctgg cctctgagtt ctaagaggca gtagagaaac atgctggtgc     2520

ttccttcccc cacgttaccc acttgcctgg actcaagtgt tttttatttt tcttttttta     2580

aaggaaactt cctgtgcaac ccagattatc acctttgaaa gtttcaaaga gaacctgaag     2640

gactttctgc ttgtcatccc ctttgactgc tgggagccag tccaggagtg agaccggcca     2700

gatgaggctg gccaagccgg ggagctgctc tctcatgaaa caagagctag aaactcagga     2760

tggtcatctt ggagggacca aggggtgggc cacagccatg gtgggagtgg cctggacctg     2820

ccctgggcca cactgaccct gatacaggca tggcagaaga atgggaatat tttatactga     2880

cagaaatcag taatatttat atatttatat ttttaaaata tttatttatt tatttattta     2940

agttcatatt ccatatttat tcaagatgtt ttaccgtaat aattattatt aaaaatatgc     3000

ttctacttgt ccagtgttct agtttgtttt taaccatgag caaatgccag tgggtgcctg     3060

ccttcccatg aggcagggga gggaggaaac ggggaggtgg agagggggcg ggggcctccc     3120

aggcgttggg cactatccaa gggccaacac tgtcagagca gaggggaggt gagagccggg     3180

catagtcgga attc                                                       3194


<210>  10
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  11
<211>  788
<212>  DNA
<213>  Homo sapiens

<400>  11
agtacacaga gagaaaggct aaagttctct ggaggatgtg gctgcagagc ctgctgctct       60

tgggcactgt ggcctgcagc atctctgcac ccgcccgctc gcccagcccc agcacgcagc      120

cctgggagca tgtgaatgcc atccaggagg cccggcgtct cctgaacctg agtagagaca      180

ctgctgctga gatgaatgaa acagtagaag tcatctcaga aatgtttgac ctccaggagc      240

cgacctgcct acagacccgc ctggagctgt acaagcaggg cctgcggggc agcctcacca      300

agctcaaggg ccccttgacc atgatggcca gccactacaa gcagcactgc cctccaaccc      360

cggaaacttc ctgtgcaacc cagattatca cctttgaaag tttcaaagag aacctgaagg      420

actttctgct tgtcatcccc tttgactgct gggagccagt ccaggagtga gaccggccag      480

atgaggctgg ccaagccggg gagctgctct ctcatgaaac aagagctaga aactcaggat      540

ggtcatcttg gagggaccaa ggggtgggcc acagccatgg tgggagtggc ctggacctgc      600

cctgggccac actgaccctg atacaggcat ggcagaagaa tgggaatatt ttatactgac      660

agaaatcagt aatatttata tatttatatt tttaaaatat ttatttattt atttatttaa      720

gttcatattc catatttatt caagatgttt taccgtaata attattatta aaaatatgct      780

tctacttg                                                               788


<210>  12
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  13
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
1               5                   10                  15      


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
            20                  25                  30          


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
        35                  40                  45              


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
    50                  55                  60                  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
65                  70                  75                  80  


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
                85                  90                  95      


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
            100                 105                 110         


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125             


<210>  14
<211>  1801
<212>  DNA
<213>  Homo sapiens

<400>  14
tttaataata attctgtgtt gcttctgaga ttaataattg attaattcat agtcaggaat       60

ctttgtaaaa aggaaaccaa ttacttttgg ctaccacttt tacatggtca cctacaggag      120

agaggaggtg ctgcaagact ctctggtaga aaaatgaaga gggtcctggt actactgctt      180

gctgtggcat ttggacatgc tttagagaga ggccgggatt atgaaaagaa taaagtctgc      240

aaggaattct cccatctggg aaaggaggac ttcacatctc tgtcactagt cctgtacagt      300

agaaaatttc ccagtggcac gtttgaacag gtcagccaac ttgtgaagga agttgtctcc      360

ttgaccgaag cctgctgtgc ggaaggggct gaccctgact gctatgacac caggacctca      420

gcactgtctg ccaagtcctg tgaaagtaat tctccattcc ccgttcaccc aggcactgct      480

gagtgctgca ccaaagaggg cctggaacga aagctctgca tggctgctct gaaacaccag      540

ccacaggaat tccctaccta cgtggaaccc acaaatgatg aaatctgtga ggcgttcagg      600

aaagatccaa aggaatatgc taatcaattt atgtgggaat attccactaa ttacggacaa      660

gctcctctgt cacttttagt cagttacacc aagagttatc tttctatggt agggtcctgc      720

tgtacctctg caagcccaac tgtatgcttt ttgaaagaga gactccagct taaacattta      780

tcacttctca ccactctgtc aaatagagtc tgctcacaat atgctgctta tggggagaag      840

aaatcaaggc tcagcaatct cataaagtta gcccaaaaag tgcctactgc tgatctggag      900

gatgttttgc cactagctga agatattact aacatcctct ccaaatgctg tgagtctgcc      960

tctgaagatt gcatggccaa agagctgcct gaacacacag taaaactctg tgacaattta     1020

tccacaaaga attctaagtt tgaagactgt tgtcaagaaa aaacagccat ggacgttttt     1080

gtgtgcactt acttcatgcc agctgcccaa ctccccgagc ttccagatgt agagttgccc     1140

acaaacaaag atgtgtgtga tccaggaaac accaaagtca tggataagta tacatttgaa     1200

ctaagcagaa ggactcatct tccggaagta ttcctcagta aggtacttga gccaacccta     1260

aaaagccttg gtgaatgctg tgatgttgaa gactcaacta cctgttttaa tgctaagggc     1320

cctctactaa agaaggaact atcttctttc attgacaagg gacaagaact atgtgcagat     1380

tattcagaaa atacatttac tgagtacaag aaaaaactgg cagagcgact aaaagcaaaa     1440

ttgcctgatg ccacacccac ggaactggca aagctggtta acaagcactc agactttgcc     1500

tccaactgct gttccataaa ctcacctcct ctttactgtg attcagagat tgatgctgaa     1560

ttgaagaata tcctgtagtc ctgaagcatg tttattaact ttgaccagag ttggagccac     1620

ccaggggaat gatctctgat gacctaacct aagcaaaacc actgagcttc tgggaagaca     1680

actaggatac tttctacttt ttctagctac aatatcttca tacaatgaca agtatgatga     1740

tttgctatca aaataaattg aaatataatg caaaccataa aaaaaaaaaa aaaaaaaaaa     1800

a                                                                     1801


<210>  15
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Tyr Thr Phe Glu Leu Ser Arg 
            340                 345                 350         


Arg Thr His Leu Pro Glu Val Phe Leu Ser Lys Val Leu Glu Pro Thr 
        355                 360                 365             


Leu Lys Ser Leu Gly Glu Cys Cys Asp Val Glu Asp Ser Thr Thr Cys 
    370                 375                 380                 


Phe Asn Ala Lys Gly Pro Leu Leu Lys Lys Glu Leu Ser Ser Phe Ile 
385                 390                 395                 400 


Asp Lys Gly Gln Glu Leu Cys Ala Asp Tyr Ser Glu Asn Thr Phe Thr 
                405                 410                 415     


Glu Tyr Lys Lys Lys Leu Ala Glu Arg Leu Lys Ala Lys Leu Pro Asp 
            420                 425                 430         


Ala Thr Pro Thr Glu Leu Ala Lys Leu Val Asn Lys His Ser Asp Phe 
        435                 440                 445             


Ala Ser Asn Cys Cys Ser Ile Asn Ser Pro Pro Leu Tyr Cys Asp Ser 
    450                 455                 460                 


Glu Ile Asp Ala Glu Leu Lys Asn Ile Leu 
465                 470                 


<210>  16
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Cys 
        35  


<210>  17
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  17

Cys Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu 
1               5                   10                  15      


Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val 
            20                  25                  30          


His Asn Phe 
        35  


