                         SEQUENCE LISTING

<110>  The Penn State Research Foundation
 
<120>  REGENERATING FUNCTIONAL NEURONS FOR TREATMENT OF SPINAL CORD 
       INJURY AND ALS

<130>  14017-0107WO1

<140>  PCT/US2020/056108
<141>  2020-10-16

<150>  US 63/040,989
<151>  2020-06-18

<150>  US 62/916,713
<151>  2019-10-17

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  1071
<212>  DNA
<213>  Homo sapiens

<400>  1
atgaccaaat cgtacagcga gagtgggctg atgggcgagc ctcagcccca aggtcctcca       60

agctggacag acgagtgtct cagttctcag gacgaggagc acgaggcaga caagaaggag      120

gacgacctcg aagccatgaa cgcagaggag gactcactga ggaacggggg agaggaggag      180

gacgaagatg aggacctgga agaggaggaa gaagaggaag aggaggatga cgatcaaaag      240

cccaagagac gcggccccaa aaagaagaag atgactaagg ctcgcctgga gcgttttaaa      300

ttgagacgca tgaaggctaa cgcccgggag cggaaccgca tgcacggact gaacgcggcg      360

ctagacaacc tgcgcaaggt ggtgccttgc tattctaaga cgcagaagct gtccaaaatc      420

gagactctgc gcttggccaa gaactacatc tgggctctgt cggagatcct gcgctcaggc      480

aaaagcccag acctggtctc cttcgttcag acgctttgca agggcttatc ccaacccacc      540

accaacctgg ttgcgggctg cctgcaactc aatcctcgga cttttctgcc tgagcagaac      600

caggacatgc ccccccacct gccgacggcc agcgcttcct tccctgtaca cccctactcc      660

taccagtcgc ctgggctgcc cagtccgcct tacggtacca tggacagctc ccatgtcttc      720

cacgttaagc ctccgccgca cgcctacagc gcagcgctgg agcccttctt tgaaagccct      780

ctgactgatt gcaccagccc ttcctttgat ggacccctca gcccgccgct cagcatcaat      840

ggcaacttct ctttcaaaca cgaaccgtcc gccgagtttg agaaaaatta tgcctttacc      900

atgcactatc ctgcagcgac actggcaggg gcccaaagcc acggatcaat cttctcaggc      960

accgctgccc ctcgctgcga gatccccata gacaatatta tgtccttcga tagccattca     1020

catcatgagc gagtcatgag tgcccagctc aatgccatat ttcatgatta g              1071


<210>  2
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Ala Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 
305                 310                 315                 320 


Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 
                325                 330                 335     


Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 
            340                 345                 350         


Ile Phe His Asp 
        355     


<210>  3
<211>  1074
<212>  DNA
<213>  Mus musculus

<400>  3
atgaccaaat catacagcga gagcgggctg atgggcgagc ctcagcccca aggtccccca       60

agctggacag atgagtgtct cagttctcag gacgaggaac acgaggcaga caagaaagag      120

gacgagcttg aagccatgaa tgcagaggag gactctctga gaaacggggg agaggaggag      180

gaggaagatg aggatctaga ggaagaggag gaagaagaag aggaggagga ggatcaaaag      240

cccaagagac ggggtcccaa aaagaaaaag atgaccaagg cgcgcctaga acgttttaaa      300

ttaaggcgca tgaaggccaa cgcccgcgag cggaaccgca tgcacgggct gaacgcggcg      360

ctggacaacc tgcgcaaggt ggtaccttgc tactccaaga cccagaaact gtctaaaata      420

gagacactgc gcttggccaa gaactacatc tgggctctgt cagagatcct gcgctcaggc      480

aaaagccctg atctggtctc cttcgtacag acgctctgca aaggtttgtc ccagcccact      540

accaatttgg tcgccggctg cctgcagctc aaccctcgga ctttcttgcc tgagcagaac      600

ccggacatgc ccccgcatct gccaaccgcc agcgcttcct tcccggtgca tccctactcc      660

taccagtccc ctggactgcc cagcccgccc tacggcacca tggacagctc ccacgtcttc      720

cacgtcaagc cgccgccaca cgcctacagc gcagctctgg agcccttctt tgaaagcccc      780

ctaactgact gcaccagccc ttcctttgac ggacccctca gcccgccgct cagcatcaat      840

ggcaacttct ctttcaaaca cgaaccatcc gccgagtttg aaaaaaatta tgcctttacc      900

atgcactacc ctgcagcgac gctggcaggg ccccaaagcc acggatcaat cttctcttcc      960

ggtgccgctg cccctcgctg cgagatcccc atagacaaca ttatgtcttt cgatagccat     1020

tcgcatcatg agcgagtcat gagtgcccag cttaatgcca tctttcacga ttag           1074


<210>  4
<211>  357
<212>  PRT
<213>  Mus musculus

<400>  4

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Glu Leu Glu Ala Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Glu Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Pro Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Pro Gln Ser His Gly Ser Ile Phe Ser Ser 
305                 310                 315                 320 


Gly Ala Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser 
                325                 330                 335     


Phe Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn 
            340                 345                 350         


Ala Ile Phe His Asp 
        355         


<210>  5
<211>  1053
<212>  DNA
<213>  Mus musculus

<400>  5
gcagtgtgga gacacaccca ctttccccaa gggctcctgc tcccccaagt gatcccctta       60

tcctccgtgc taagatgaca ccgaggttgc agtccttacc tttgaaagca gccacaaggg      120

cgtgggggtg cacaccttta atcccagcac tcgggaggca gaggcaggca gatttctgag      180

ttcgagacca gcctggtcta caaagtgaat tccaggacag ccagggctat acagagaaac      240

cctgtcttga aaaaaaaaga gaaagaaaaa agaaaaaaaa aaatgaaagc agccacatct      300

aaggactacg tggcacagga gagggtgagt ccctgagagt tcagctgctg ccctgtctgt      360

tcctgtaaat ggcagtgggg tcatgggaaa gtgaaggggc tcaaggtatt ggacacttcc      420

aggataatct tttggacgcc tcaccctgtg ccaggaccaa ggctgagctt ggcaggctca      480

gaacagggtg tcctgttctt ccctgtctaa aacattcact ctcagcttgc tcacccttcc      540

ccagacaagg aagctgcaca gggtctggtg ttcagatggc tttggcttac agcaggtgtg      600

ggtgtggggt aggaggcagg gggtaggggt gggggaagcc tgtactatac tcactatcct      660

gtttctgacc ctctaggact cctacagggt tatgggagtg gacaggcagt ccagatctga      720

gctgctgacc cacaagcagt gccctgtgcc tgccagaatc caaagccctg ggaatgtccc      780

tctggtcccc ctctgtcccc tgcagccctt cctgttgctc aaccttgcac agttccgacc      840

tgggggagag agggacagaa atcttgccaa gtatttcaac agaatgtact ggcaattact      900

tcatggcttc ctggacttgg taaaggatgg actaccccgc ccaacagggg ggctggcagc      960

caggtaggcc cataaaaagc ccgctgggga gtcctcctca ctctctgctc ttcctcctcc     1020

agcacacatc agacctagta gctgtggaaa cca                                  1053


<210>  6
<211>  1672
<212>  DNA
<213>  Homo sapiens

<400>  6
gtctgcaagc agacctggca gcattgggct ggccgccccc cagggcctcc tcttcatgcc       60

cagtgaatga ctcaccttgg cacagacaca atgttcgggg tgggcacagt gcctgcttcc      120

cgccgcaccc cagcccccct caaatgcctt ccgagaagcc cattgagtag ggggcttgca      180

ttgcacccca gcctgacagc ctggcatctt gggataaaag cagcacagcc ccctaggggc      240

tgcccttgct gtgtggcgcc accggcggtg gagaacaagg ctctattcag cctgtgccca      300

ggaaagggga tcaggggatg cccaggcatg gacagtgggt ggcagggggg gagaggaggg      360

ctgtctgctt cccagaagtc caaggacaca aatgggtgag gggactgggc agggttctga      420

ccctgtggga ccagagtgga gggcgtagat ggacctgaag tctccaggga caacagggcc      480

caggtctcag gctcctagtt gggcccagtg gctccagcgt ttccaaaccc atccatcccc      540

agaggttctt cccatctctc caggctgatg tgtgggaact cgaggaaata aatctccagt      600

gggagacgga ggggtggcca gggaaacggg gcgctgcagg aataaagacg agccagcaca      660

gccagctcat gcgtaacggc tttgtggagc tgtcaaggcc tggtctctgg gagagaggca      720

cagggaggcc agacaaggaa ggggtgacct ggagggacag atccaggggc taaagtcctg      780

ataaggcaag agagtgccgg ccccctcttg ccctatcagg acctccactg ccacatagag      840

gccatgattg acccttagac aaagggctgg tgtccaatcc cagcccccag ccccagaact      900

ccagggaatg aatgggcaga gagcaggaat gtgggacatc tgtgttcaag ggaaggactc      960

caggagtctg ctgggaatga ggcctagtag gaaatgaggt ggcccttgag ggtacagaac     1020

aggttcattc ttcgccaaat tcccagcacc ttgcaggcac ttacagctga gtgagataat     1080

gcctgggtta tgaaatcaaa aagttggaaa gcaggtcaga ggtcatctgg tacagccctt     1140

ccttcccttt tttttttttt ttttttgtga gacaaggtct ctctctgttg cccaggctgg     1200

agtggcgcaa acacagctca ctgcagcctc aacctactgg gctcaagcaa tcctccagcc     1260

tcagcctccc aaagtgctgg gattacaagc atgagccacc ccactcagcc ctttccttcc     1320

tttttaattg atgcataata attgtaagta ttcatcatgg tccaaccaac cctttcttga     1380

cccaccttcc tagagagagg gtcctcttga ttcagcggtc agggccccag acccatggtc     1440

tggctccagg taccacctgc ctcatgcagg agttggcgtg cccaggaagc tctgcctctg     1500

ggcacagtga cctcagtggg gtgaggggag ctctccccat agctgggctg cggcccaacc     1560

ccaccccctc aggctatgcc agggggtgtt gccaggggca cccgggcatc gccagtctag     1620

cccactcctt cataaagccc tcgcatccca ggagcgagca gagccagagc at             1672


<210>  7
<211>  1610
<212>  DNA
<213>  Mus musculus

<400>  7
aactgagagt ggaggggcac agaagagccc aagaggctcc ttaggttgtg tggagggtac       60

aatatgtttg ggctgagcaa cccagagcca gactttgtct ggctggtaag agacagaggt      120

gcctgctatc acaatccaag ggtctgcttg aggcagagcc agtgcaaagg atgtggttag      180

agccagcctg gtgtactgaa gaggggcgaa gagcttgagt aaggagtctc agcggtggtt      240

tgagaggcag ggtggttaat ggagtagctg caggggagaa tccttgggag ggagcctgca      300

ggacagagct ttggtcagga agtgatgggc atgtcactgg accctgtatt gtctctgact      360

tttctcaagt aggacaatga ctctgcccag ggagggggtc tgtgacaagg tggaagggcc      420

agaggagaac ttctgagaag aaaaccagag gccgtgaaga ggtgggaagg gcatgggatt      480

cagaacctca ggcccaccag gacacaaccc caggtccaca gcagatgggt gaccttgcat      540

gtctcagtca ccagcattgt gctccttgct tatcacgctt gggtgaagga aatgacccaa      600

atagcataaa gcctgaaggc cgggactagg ccagctaggg cttgcccttc ccttcccagc      660

tgcactttcc ataggtccca ccttcagcag attagacccg cctcctgctt cctgcctcct      720

tgcctcctca ctcatgggtc tatgcccacc tccagtctcg ggactgaggc tcactgaagt      780

cccatcgagg tctggtctgg tgaatcagcg gctggctctg ggccctgggc gaccagttag      840

gttccgggca tgctaggcaa tgaactctac ccggaattgg gggtgcgggg aggcggggag      900

gtctccaacc cagccttttg aggacgtgcc tgtcgctgca cggtgctttt tatagacgat      960

ggtggcccat tttgcagaag ggaaagccgg agccctctgg ggagcaaggt ccccgcaaat     1020

ggacggatga cctgagcttg gttctgccag tccacttccc aaatccctca ccccattcta     1080

gggactaggg aaagatctcc tgattggtca tatctggggg cctggccgga gggcctccta     1140

tgattggaga gatctaggct gggcgggccc tagagcccgc ctcttctctg cctggaggag     1200

gagcactgac cctaaccctc tctgcacaag acccgagctt gtgcgccctt ctgggagctt     1260

gctgcccctg tgctgactgc tgacagctga ctgacgctcg cagctagcag gtacttctgg     1320

gttgctagcc cagagccctg ggccggtgac cctgttttcc ctacttcccg tctttgacct     1380

tgggtaagtt tctttttctt ttgtttttga gagaggcacc cagatcctct ccactacagg     1440

cagccgctga accttggatc ctcagctcct gccctgggaa ctacagttcc tgcccttttt     1500

ttcccacctt gagggaggtt ttccctgagt agcttcgact atcctggaac aagctttgta     1560

gaccagcctg ggtctccgga gagttgggat taaaggcgtg caccaccacc                1610


<210>  8
<211>  1387
<212>  DNA
<213>  Homo sapiens

<400>  8
ctctggtttc aagaccaata ctcataaccc ccacatggac caggcaccat cacacctgag       60

cactgcactt agggtcaaag acctggcccc acatctcagc agctatgtag actagctcca      120

gtcccttaat ctctctcagc ctcagtttct tcatctgcaa aacaggtctc agtttcgttg      180

caaagtatga agtgctgggc tgttactggt caaagggaag agctgggaag agggtgcaag      240

gtggggttgg gctggagatg ggctggagca gatagatgga gggacctgaa tggaggaagt      300

aaaccaaggc ccggtaacat tgggactgga cagagaacac gcagatcctc taggcaccgg      360

aagctaagta acattgccct ttctcctcct gtttgggact aggctgatgt tgctgcctgg      420

aagggagcca gcagaagggc cccagcctga agctgttagg tagaagccaa atccagggcc      480

agatttccag gaggcagcct cgggaagttg aaacacccgg attcaggggt caggaggcct      540

gggcttctgg caccaaacgg ccagggacct actttccacc tggagtcttg taagagccac      600

tttcagcttg agctgcactt tcgtcctcca tgaaatgggg gaggggatgc tcctcaccca      660

ccttgcaagg ttattttgag gcaaatgtca tggcgggact gagaattctt ctgccctgcg      720

aggaaatcca gacatctctc ccttacagac agggagactg aggtgaggcc cttccaggca      780

gagaaggtca ctgttgcagc catgggcagt gccccacagg acctcgggtg gtgcctctgg      840

agtctggaga agttcctagg ggacctccga ggcaaagcag cccaaaagcc gcctgtgagg      900

gtggctggtg tctgtccttc ctcctaaggc tggagtgtgc ctgtggaggg gtctcctgaa      960

ctcccgcaaa ggcagaaagg agggaagtag gggctgggac agttcatgcc tcctccctga     1020

gggggtctcc cgggctcggc tcttggggcc agagttcagg gtgtctgggc ctctctatga     1080

ctttgttcta agtctttagg gtggggctgg ggtctggccc agctgcaagg gccccctcac     1140

ccctgcccca gagaggaaca gccccgcacg ggccctttaa gaaggttgag ggtgggggca     1200

ggtgggggag tccaagcctg aaacccgagc gggcgcgcgg gtctgcgcct gccccgcccc     1260

cggagttaag tgcgcggaca cccggagccg gcccgcgccc aggagcagag ccgcgctcgc     1320

tccactcagc tcccagctcc caggactccg ctggctcctc gcaagtcctg ccgcccagcc     1380

cgccggg                                                               1387


<210>  9
<211>  9232
<212>  DNA
<213>  Artificial

<220>
<223>  vector construct

<400>  9
gatccggcca ttagccatat tattcattgg ttatatagca taaatcaata ttggctattg       60

gccattgcat acgttgtatc catatcataa tatgtacatt tatattggct catgtccaac      120

attaccgcca tgttgacatt gattattgac tagttattaa tagtaatcaa ttacggggtc      180

attagttcat agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc      240

tggctgaccg cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt      300

aacgccaata gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca      360

cttggcagta catcaagtgt atcatatgcc aagtacgccc cctattgacg tcaatgacgg      420

taaatggccc gcctggcatt atgcccagta catgacctta tgggactttc ctacttggca      480

gtacatctac gtattagtca tcgctattac catggtgatg cggttttggc agtacatcaa      540

tgggcgtgga tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa      600

tgggagtttg ttttggcacc aaaatcaacg ggactttcca aaatgtcgta acaactccgc      660

cccattgacg caaatgggcg gtaggcatgt acggtgggag gtctatataa gcagagctca      720

ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg      780

ggtacccgta ttcccaataa agcctcttgc tgtttgcatc cgaatcgtgg tctcgctgtt      840

ccttgggagg gtctcctctg agtgattgac tacccacgac gggggtcttt catttggggg      900

ctcgtccggg atttggagac ccctgcccag ggaccaccga cccaccaccg ggaggtaagc      960

tggccagcaa cttatctgtg tctgtccgat tgtctagtgt ctatgtttga tgttatgcgc     1020

ctgcgtctgt actagttagc taactagctc tgtatctggc ggacccgtgg tggaactgac     1080

gagttctgaa cacccggccg caaccctggg agacgtccca gggactttgg gggccgtttt     1140

tgtggcccga cctgaggaag ggagtcgatg tggaatccga ccccgtcagg atatgtggtt     1200

ctggtaggag acgagaacct aaaacagttc ccgcctccgt ctgaattttt gctttcggtt     1260

tggaaccgaa gccgcgcgtc ttgtctgctg cagcgctgca gcatcgttct gtgttgtctc     1320

tgtctgactg tgtttctgta tttgtctgaa aattagggcc agactgttac cactccctta     1380

agtttgacct taggtcactg gaaagatgtc gagcggatcg ctcacaacca gtcggtagat     1440

gtcaagaaga gacgttgggt taccttctgc tctgcagaat ggccaacctt taacgtcgga     1500

tggccgcgag acggcacctt taaccgagac ctcatcaccc aggttaagat caaggtcttt     1560

tcacctggcc cgcatggaca cccagaccag gtcccctaca tcgtgacctg ggaagccttg     1620

gcttttgacc cccctccctg ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt     1680

cctccatccg ccccgtctct cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc     1740

ctttatccag ccctcactcc ttctctaggc gccggaattc gatgtcgaca ttgattattg     1800

actagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc     1860

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca     1920

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt     1980

caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg     2040

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag     2100

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt     2160

accatgggtc gaggtgagcc ccacgttctg cttcactctc cccatctccc ccccctcccc     2220

acccccaatt ttgtatttat ttatttttta attattttgt gcagcgatgg gggcgggggg     2280

ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga     2340

gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc     2400

ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgttgc     2460

cttcgccccg tgccccgctc cgcgccgcct cgcgccgccc gccccggctc tgactgaccg     2520

cgttactccc acaggtgagc gggcgggacg gcccttctcc tccgggctgt aattagcgct     2580

tggtttaatg acggctcgtt tcttttctgt ggctgcgtga aagccttaaa gggctccggg     2640

agggcccttt gtgcgggggg gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg     2700

agcgccgcgt gcggcccgcg ctgcccggcg gctgtgagcg ctgcgggcgc ggcgcggggc     2760

tttgtgcgct ccgcgtgtgc gcgaggggag cgcggccggg ggcggtgccc cgcggtgcgg     2820

gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt gcgtgggggg gtgagcaggg     2880

ggtgtgggcg cggcggtcgg gctgtaaccc ccccctgcac ccccctcccc gagttgctga     2940

gcacggcccg gcttcgggtg cggggctccg tgcggggcgt ggcgcggggc tcgccgtgcc     3000

gggcgggggg tggcggcagg tgggggtgcc gggcggggcg gggccgcctc gggccgggga     3060

gggctcgggg gaggggcgcg gcggccccgg agcgccggcg gctgtcgagg cgcggcgagc     3120

cgcagccatt gccttttatg gtaatcgtgc gagagggcgc agggacttcc tttgtcccaa     3180

atctggcgga gccgaaatct gggaggcgcc gccgcacccc ctctagcggg cgcgggcgaa     3240

gcggtgcggc gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg     3300

ccgtcccctt ctccatctcc agcctcgggg ctgccgcagg gggacggctg ccttcggggg     3360

ggacggggca gggcggggtt cggcttctgg cgtgtgaccg gcggctctag agcctctgct     3420

aaccatgttc atgccttctt ctttttccta cagctcctgg gcaacgtgct ggttgttgtg     3480

ctgtctcatc attttggcaa agaattcgct agcggatccg gccgcctcgg ccaccggtcg     3540

ccaccatcgc caccatgacc aaatcataca gcgagagcgg gctgatgggc gagcctcagc     3600

cccaaggtcc cccaagctgg acagatgagt gtctcagttc tcaggacgag gaacacgagg     3660

cagacaagaa agaggacgag cttgaagcca tgaatgcaga ggaggactct ctgagaaacg     3720

ggggagagga ggaggaggaa gatgaggatc tagaggaaga ggaggaagaa gaagaggagg     3780

aggaggatca aaagcccaag agacggggtc ccaaaaagaa aaagatgacc aaggcgcgcc     3840

tagaacgttt taaattaagg cgcatgaagg ccaacgcccg cgagcggaac cgcatgcacg     3900

ggctgaacgc ggcgctggac aacctgcgca aggtggtacc ttgctactcc aagacccaga     3960

aactgtctaa aatagagaca ctgcgcttgg ccaagaacta catctgggct ctgtcagaga     4020

tcctgcgctc aggcaaaagc cctgatctgg tctccttcgt acagacgctc tgcaaaggtt     4080

tgtcccagcc cactaccaat ttggtcgccg gctgcctgca gctcaaccct cggactttct     4140

tgcctgagca gaacccggac atgcccccgc atctgccaac cgccagcgct tccttcccgg     4200

tgcatcccta ctcctaccag tcccctggac tgcccagccc gccctacggc accatggaca     4260

gctcccacgt cttccacgtc aagccgccgc cacacgccta cagcgcagct ctggagccct     4320

tctttgaaag ccccctaact gactgcacca gcccttcctt tgacggaccc ctcagcccgc     4380

cgctcagcat caatggcaac ttctctttca aacacgaacc atccgccgag tttgaaaaaa     4440

attatgcctt taccatgcac taccctgcag cgacgctggc agggccccaa agccacggat     4500

caatcttctc ttccggtgcc gctgcccctc gctgcgagat ccccatagac aacattatgt     4560

ctttcgatag ccattcgcat catgagcgag tcatgagtgc ccagcttaat gccatctttc     4620

acgattaggt ttaaacgcgg ccgcgcccct ctccctcccc cccccctaac gttactggcc     4680

gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc     4740

cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta     4800

ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag     4860

ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga     4920

accccccacc tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg     4980

caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat     5040

ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta     5100

tgggatctga tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa     5160

aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat     5220

atggccacaa ccatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg     5280

gtcgagctgg acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc     5340

gatgccacct acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg     5400

ccctggccca ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc     5460

gaccacatga agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag     5520

cgcaccatct tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag     5580

ggcgacaccc tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac     5640

atcctggggc acaagctgga gtacaactac aacagccaca acgtctatat catggccgac     5700

aagcagaaga acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc     5760

gtgcagctcg ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg     5820

cccgacaacc actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc     5880

gatcacatgg tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag     5940

ctgtacaagt aagtcgacaa tcaacctctg gattacaaaa tttgtgaaag attgactggt     6000

attcttaact atgttgctcc ttttacgcta tgtggatacg ctgctttaat gcctttgtat     6060

catgctattg cttcccgtat ggctttcatt ttctcctcct tgtataaatc ctggttgctg     6120

tctctttatg aggagttgtg gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt     6180

gctgacgcaa cccccactgg ttggggcatt gccaccacct gtcagctcct ttccgggact     6240

ttcgctttcc ccctccctat tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc     6300

tggacagggg ctcggctgtt gggcactgac aattccgtgg tgttgtcggg gaagctgacg     6360

tcctttccat ggctgctcgc ctgtgttgcc acctggattc tgcgcgggac gtccttctgc     6420

tacgtccctt cggccctcaa tccagcggac cttccttccc gcggcctgct gccggctctg     6480

cggcctcttc cgcgtcttcg ccttcgccct cagacgagtc ggatctccct ttgggccgcc     6540

tccccgcctg gaattcgagc tcgagcttgt taacatcgat aaaataaaag attttattta     6600

gtctccagaa aaagggggga atgaaagacc ccacctgtag gtttggcaag ctagcttaag     6660

taacgccatt ttgcaaggca tggaaaaata cataactgag aatagagaag ttcagatcaa     6720

ggtcaggaac agatggaaca gctgaatatg ggccaaacag gatatctgtg gtaagcagtt     6780

cctgccccgg ctcagggcca agaacagatg gaacagctga atatgggcca aacaggatat     6840

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt     6900

ccagccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga     6960

aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg     7020

cttctgctcc ccgagctcaa taaaagagcc cacaacccct cactcggggc gccagtcctc     7080

cgattgactg agtcgcccgg gtacccgtgt atccaataaa ccctcttgca gttgcatccg     7140

acttgtggtc tcgctgttcc ttgggagggt ctcctctgag tgattgacta cccgtcagcg     7200

ggggtctttc atttccgact tgtggtctcg ctgccttggg agggtctcct ctgagtgatt     7260

gactacccgt cagcgggggt cttcacatgc agcatgtatc aaaattaatt tggttttttt     7320

tcttaagtat ttacattaaa tggccatagt tgcattaatg aatcggccaa cgcgcgggga     7380

gaggcggttt gcgtattggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt     7440

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     7500

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     7560

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     7620

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     7680

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     7740

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     7800

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     7860

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     7920

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     7980

tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat     8040

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     8100

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     8160

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     8220

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     8280

tttaaattaa aaatgaagtt tgcggccggc cgcaaatcaa tctaaagtat atatgagtaa     8340

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     8400

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     8460

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     8520

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     8580

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     8640

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     8700

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     8760

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     8820

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     8880

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     8940

cggcgaccga gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga     9000

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     9060

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     9120

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     9180

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca at             9232


<210>  10
<211>  987
<212>  DNA
<213>  Homo sapiens

<400>  10
atgactggag tctttgacag tctagtggct gatatgcact cgacccagat cgccgcctcc       60

agcacgtacc accagcacca gcagcccccg agcggcggcg gcgccggccc gggtggcaac      120

agcagcagca gcagcagcct ccacaagccc caggagtcgc ccacccttcc ggtgtccacc      180

gccaccgaca gcagctacta caccaaccag cagcacccgg cgggcggcgg cggcggcggg      240

ggctcgccct acgcgcacat gggttcctac cagtaccaag ccagcggcct caacaacgtc      300

ccttactccg ccaagagcag ctatgacctg ggctacaccg ccgcctacac ctcctacgct      360

ccctatggaa ccagttcgtc cccagccaac aacgagcctg agaaggagga ccttgagcct      420

gaaattcgga tagtgaacgg gaagccaaag aaagtccgga aaccccgcac catctactcc      480

agtttccagc tggcggctct tcagcggcgt ttccaaaaga ctcaatactt ggccttgccg      540

gagcgagccg agctggcggc ctctctgggc ctcacccaga ctcaggtcaa aatctggttc      600

cagaaccgcc ggtccaagtt caagaagatg tggaaaagtg gtgagatccc ctcggagcag      660

caccctgggg ccagcgcttc tccaccttgt gcttcgccgc cagtctcagc gccggcctcc      720

tgggactttg gtgtgccgca gcggatggcg ggcggcggtg gtccgggcag tggcggcagc      780

ggcgccggca gctcgggctc cagcccgagc agcgcggcct cggcttttct gggcaactac      840

ccctggtacc accagacctc gggatccgcc tcacacctgc aggccacggc gccgctgctg      900

caccccactc agaccccgca gccgcatcac caccaccacc atcacggcgg cgggggcgcc      960

ccggtgagcg cggggacgat tttctaa                                          987


<210>  11
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Gly Val Phe Asp Ser Leu Val Ala Asp Met His Ser Thr Gln 
1               5                   10                  15      


Ile Ala Ala Ser Ser Thr Tyr His Gln His Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Gly Gly Ala Gly Pro Gly Gly Asn Ser Ser Ser Ser Ser Ser Leu His 
        35                  40                  45              


Lys Pro Gln Glu Ser Pro Thr Leu Pro Val Ser Thr Ala Thr Asp Ser 
    50                  55                  60                  


Ser Tyr Tyr Thr Asn Gln Gln His Pro Ala Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Pro Tyr Ala His Met Gly Ser Tyr Gln Tyr Gln Ala Ser Gly 
                85                  90                  95      


Leu Asn Asn Val Pro Tyr Ser Ala Lys Ser Ser Tyr Asp Leu Gly Tyr 
            100                 105                 110         


Thr Ala Ala Tyr Thr Ser Tyr Ala Pro Tyr Gly Thr Ser Ser Ser Pro 
        115                 120                 125             


Ala Asn Asn Glu Pro Glu Lys Glu Asp Leu Glu Pro Glu Ile Arg Ile 
    130                 135                 140                 


Val Asn Gly Lys Pro Lys Lys Val Arg Lys Pro Arg Thr Ile Tyr Ser 
145                 150                 155                 160 


Ser Phe Gln Leu Ala Ala Leu Gln Arg Arg Phe Gln Lys Thr Gln Tyr 
                165                 170                 175     


Leu Ala Leu Pro Glu Arg Ala Glu Leu Ala Ala Ser Leu Gly Leu Thr 
            180                 185                 190         


Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ser Lys Phe Lys 
        195                 200                 205             


Lys Met Trp Lys Ser Gly Glu Ile Pro Ser Glu Gln His Pro Gly Ala 
    210                 215                 220                 


Ser Ala Ser Pro Pro Cys Ala Ser Pro Pro Val Ser Ala Pro Ala Ser 
225                 230                 235                 240 


Trp Asp Phe Gly Val Pro Gln Arg Met Ala Gly Gly Gly Gly Pro Gly 
                245                 250                 255     


Ser Gly Gly Ser Gly Ala Gly Ser Ser Gly Ser Ser Pro Ser Ser Ala 
            260                 265                 270         


Ala Ser Ala Phe Leu Gly Asn Tyr Pro Trp Tyr His Gln Thr Ser Gly 
        275                 280                 285             


Ser Ala Ser His Leu Gln Ala Thr Ala Pro Leu Leu His Pro Thr Gln 
    290                 295                 300                 


Thr Pro Gln Pro His His His His His His His Gly Gly Gly Gly Ala 
305                 310                 315                 320 


Pro Val Ser Ala Gly Thr Ile Phe 
                325             


<210>  12
<211>  999
<212>  DNA
<213>  Mus musculus

<400>  12
atgactggag tctttgacag tctggtggct gatatgcact cgacccagat caccgcctcc       60

agcacgtacc accagcacca gcagcccccg agcggtgcgg gcgccggccc tggcggcaac      120

agcaacagca gcagcagcaa cagcagcctg cacaagcccc aggagtcgcc aaccctcccg      180

gtgtccacgg ctacggacag cagctactac accaaccagc agcacccggc gggcggcggc      240

ggcggggggg cctcgcccta cgcgcacatg ggctcctacc agtaccacgc cagcggcctc      300

aacaatgtct cctactccgc caaaagcagc tacgacctgg gctacaccgc cgcgtacacc      360

tcctacgcgc cctacggcac cagttcgtct ccggtcaaca acgagccgga caaggaagac      420

cttgagcctg aaatccgaat agtgaacggg aagccaaaga aagtccggaa accacgcacc      480

atctactcca gtttccagct ggcggccctt caacgacgct tccagaagac ccagtatctg      540

gccctgccag agcgagccga gctggcggcg tccctgggcc tcacccaaac tcaggtcaaa      600

atctggttcc agaaccgccg atccaagttc aagaagatgt ggaaaagcgg cgagataccc      660

accgagcagc accctggagc cagcgcttct cctccttgtg cctccccgcc ggtctcggcg      720

ccagcatcct gggacttcgg cgcgccgcag cggatggctg gcggcggccc gggcagcgga      780

ggcggcggtg cgggcagctc tggctccagc ccgagcagcg ccgcctcggc ctttctggga      840

aactacccgt ggtaccacca ggcttcgggc tccgcttcac acctgcaggc cacagcgcca      900

cttctgcatc cttcgcagac tccgcaggcg caccatcacc accatcacca ccaccacgca      960

ggcgggggcg ccccggtgag cgcggggacg attttctaa                             999


<210>  13
<211>  332
<212>  PRT
<213>  Mus musculus

<400>  13

Met Thr Gly Val Phe Asp Ser Leu Val Ala Asp Met His Ser Thr Gln 
1               5                   10                  15      


Ile Thr Ala Ser Ser Thr Tyr His Gln His Gln Gln Pro Pro Ser Gly 
            20                  25                  30          


Ala Gly Ala Gly Pro Gly Gly Asn Ser Asn Ser Ser Ser Ser Asn Ser 
        35                  40                  45              


Ser Leu His Lys Pro Gln Glu Ser Pro Thr Leu Pro Val Ser Thr Ala 
    50                  55                  60                  


Thr Asp Ser Ser Tyr Tyr Thr Asn Gln Gln His Pro Ala Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Ala Ser Pro Tyr Ala His Met Gly Ser Tyr Gln Tyr His 
                85                  90                  95      


Ala Ser Gly Leu Asn Asn Val Ser Tyr Ser Ala Lys Ser Ser Tyr Asp 
            100                 105                 110         


Leu Gly Tyr Thr Ala Ala Tyr Thr Ser Tyr Ala Pro Tyr Gly Thr Ser 
        115                 120                 125             


Ser Ser Pro Val Asn Asn Glu Pro Asp Lys Glu Asp Leu Glu Pro Glu 
    130                 135                 140                 


Ile Arg Ile Val Asn Gly Lys Pro Lys Lys Val Arg Lys Pro Arg Thr 
145                 150                 155                 160 


Ile Tyr Ser Ser Phe Gln Leu Ala Ala Leu Gln Arg Arg Phe Gln Lys 
                165                 170                 175     


Thr Gln Tyr Leu Ala Leu Pro Glu Arg Ala Glu Leu Ala Ala Ser Leu 
            180                 185                 190         


Gly Leu Thr Gln Thr Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ser 
        195                 200                 205             


Lys Phe Lys Lys Met Trp Lys Ser Gly Glu Ile Pro Thr Glu Gln His 
    210                 215                 220                 


Pro Gly Ala Ser Ala Ser Pro Pro Cys Ala Ser Pro Pro Val Ser Ala 
225                 230                 235                 240 


Pro Ala Ser Trp Asp Phe Gly Ala Pro Gln Arg Met Ala Gly Gly Gly 
                245                 250                 255     


Pro Gly Ser Gly Gly Gly Gly Ala Gly Ser Ser Gly Ser Ser Pro Ser 
            260                 265                 270         


Ser Ala Ala Ser Ala Phe Leu Gly Asn Tyr Pro Trp Tyr His Gln Ala 
        275                 280                 285             


Ser Gly Ser Ala Ser His Leu Gln Ala Thr Ala Pro Leu Leu His Pro 
    290                 295                 300                 


Ser Gln Thr Pro Gln Ala His His His His His His His His His Ala 
305                 310                 315                 320 


Gly Gly Gly Ala Pro Val Ser Ala Gly Thr Ile Phe 
                325                 330         


<210>  14
<211>  2448
<212>  DNA
<213>  Homo sapiens

<400>  14
tgaaggaaga ggaagaggag gagagggagg ccagagccag aacagcccgg cagcccgggc       60

ttcgggggag aacggcctga gccccgagca agttgcctcg ggagccctaa tcctctcccg      120

ctggctcgcc gagcggtcag tggcgctcag cggcggcgag gctgaaatat gataatcaga      180

acagctgcgc cgcgcgccct gcagccaatg ggcgcggcgc tcgcctgacg tccccgcgcg      240

ctgcgtcaga ccaatggcga tggagctgag ttggagcaga gaagtttgag taagagataa      300

ggaagagagg tgcccgagcc gcgccgagtc tgccgccgcc gcagcgcctc cgctccgcca      360

actccgccgg cttaaattgg aatcctagat ccgcgagggc gcggcgcagc cgagcagcgg      420

ctctttcagc attggcaacc ccaggggcca atatttccca cttagccaca gctccagcat      480

cctctctgtg ggctgttcac cagctgtaca accaccattt cactgtggac attactccct      540

cttacagata tgggagacat gggagatcca ccaaaaaaaa aacgtctgat ttccctatgt      600

gttggttgcg gcaatcagat tcacgatcag tatattctga gggtttctcc ggatttggaa      660

tggcatgcgg catgtttgaa atgtgcggag tgtaatcagt atttggacga gagctgtaca      720

tgctttgtta gggatgggaa aacctactgt aaaagagatt atatcaggtt gtacgggatc      780

aaatgcgcca agtgcagcat cggcttcagc aagaacgact tcgtgatgcg tgcccgctcc      840

aaggtgtatc acatcgagtg tttccgctgt gtggcctgca gccgccagct catccctggg      900

gacgaatttg cgcttcggga ggacggtctc ttctgccgag cagaccacga tgtggtggag      960

agggccagtc taggcgctgg cgacccgctc agtcccctgc atccagcgcg gccactgcaa     1020

atggcagcgg agcccatctc cgccaggcag ccggccctgc ggccccacgt ccacaagcag     1080

ccggagaaga ccacccgcgt gcggactgtg ctgaacgaga agcagctgca caccttgcgg     1140

acctgctacg ccgcaaaccc gcggccagat gcgctcatga aggagcaact ggtagagatg     1200

acgggcctca gtccccgtgt gatccgggtc tggtttcaaa acaagcggtg caaggacaag     1260

aagcgaagca tcatgatgaa gcaactccag cagcagcagc ccaatgacaa aactaatatc     1320

caggggatga caggaactcc catggtggct gccagtccag agagacacga cggtggctta     1380

caggctaacc cagtggaagt acaaagttac cagccacctt ggaaagtact gagcgacttc     1440

gccttgcaga gtgacataga tcagcctgct tttcagcaac tggtcaattt ttcagaagga     1500

ggaccgggct ctaattccac tggcagtgaa gtagcatcaa tgtcctctca acttccagat     1560

acacctaaca gcatggtagc cagtcctatt gaggcatgag gaacattcat tctgtatttt     1620

ttttccctgt tggagaaagt gggaaattat aatgtcgaac tctgaaacaa aagtatttaa     1680

cgacccagtc aatgaaaact gaatcaagaa atgaatgctc catgaaatgc acgaagtctg     1740

ttttaatgac aaggtgatat ggtagcaaca ctgtgaagac aatcatggga ttttactaga     1800

attaaacaac aaacaaaacg caaaacccag tatatgctat tcaatgatct tagaagtact     1860

gaaaaaaaaa gacgttttta aaacgtagag gatttatatt caaggatctc aaagaaagca     1920

ttttcatttc actgcacatc tagagaaaaa caaaaataga aaattttcta gtccatccta     1980

atctgaatgg tgctgtttct atattggtca ttgccttgcc aaacaggagc tccagcaaaa     2040

gcgcaggaag agagactggc ctccttggct gaaagagtcc tttcaggaag gtggagctgc     2100

attggtttga tatgtttaaa gttgacttta acaaggggtt aattgaaatc ctgggtctct     2160

tggcctgtcc tgtagctggt ttatttttta ctttgccccc tccccacttt ttttgagatc     2220

catcctttat caagaagtct gaagcgactt taaaggtttt tgaattcaga tttaaaaacc     2280

aacttataaa gcattgcaac aaggttacct ctattttgcc acaagcgtct cgggattgtg     2340

tttgacttgt gtctgtccaa gaacttttcc cccaaagatg tgtatagtta ttggttaaaa     2400

tgactgtttt ctctctctat ggaaataaaa aggaaaaaaa aaaaaaaa                  2448


<210>  15
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Asp Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu 
1               5                   10                  15      


Cys Val Gly Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val 
            20                  25                  30          


Ser Pro Asp Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys 
        35                  40                  45              


Asn Gln Tyr Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys 
    50                  55                  60                  


Thr Tyr Cys Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala 
65                  70                  75                  80  


Lys Cys Ser Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg 
                85                  90                  95      


Ser Lys Val Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg 
            100                 105                 110         


Gln Leu Ile Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe 
        115                 120                 125             


Cys Arg Ala Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly 
    130                 135                 140                 


Asp Pro Leu Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala 
145                 150                 155                 160 


Glu Pro Ile Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys 
                165                 170                 175     


Gln Pro Glu Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln 
            180                 185                 190         


Leu His Thr Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala 
        195                 200                 205             


Leu Met Lys Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val 
    210                 215                 220                 


Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser 
225                 230                 235                 240 


Ile Met Met Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn 
                245                 250                 255     


Ile Gln Gly Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg 
            260                 265                 270         


His Asp Gly Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln 
        275                 280                 285             


Pro Pro Trp Lys Val Leu Ser Asp Phe Ala Leu Gln Ser Asp Ile Asp 
    290                 295                 300                 


Gln Pro Ala Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly 
305                 310                 315                 320 


Ser Asn Ser Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro 
                325                 330                 335     


Asp Thr Pro Asn Ser Met Val Ala Ser Pro Ile Glu Ala 
            340                 345                 


<210>  16
<211>  1307
<212>  DNA
<213>  Mus musculus

<400>  16
caactccgcc ggcttaaatc ggactcccag atctgcgagg gcgcggcgca gccgggcagc       60

tgtttccccc agttttggca accccggggg ccactatttg ccacctagcc acagcaccag      120

catcctctct gtgggctatt caccaattgt ccaaccacca tttcactgtg gacgttactc      180

cctcttacag atatgggaga catgggcgat ccaccaaaaa aaaaacgtct gatttccctg      240

tgtgttggtt gcggcaatca aattcacgac cagtatattc tgagggtttc tccggatttg      300

gagtggcatg cagcatgttt gaaatgtgcg gagtgtaatc agtatttgga cgaaagctgt      360

acgtgctttg ttagggatgg gaaaacctac tgtaaaagag attatatcag gttgtacggg      420

atcaaatgcg ccaagtgcag cataggcttc agcaagaacg acttcgtgat gcgcgcccgc      480

tctaaggtgt accacatcga gtgtttccgc tgtgtagcct gcagccgaca gctcatcccg      540

ggagacgaat tcgccctgcg ggaggatggg cttttctgcc gtgcagacca cgatgtggtg      600

gagagagcca gcctgggagc tggagaccct ctcagtccct tgcatccagc gcggcctctg      660

caaatggcag ccgaacccat ctcggctagg cagccagctc tgcggccgca cgtccacaag      720

cagccggaga agaccacccg agtgcggact gtgctcaacg agaagcagct gcacaccttg      780

cggacctgct atgccgccaa ccctcggcca gatgcgctca tgaaggagca actagtggag      840

atgacgggcc tcagtcccag agtcatccga gtgtggtttc aaaacaagcg gtgcaaggac      900

aagaaacgca gcatcatgat gaagcagctc cagcagcagc aacccaacga caaaactaat      960

atccagggga tgacaggaac tcccatggtg gctgctagtc cggagagaca tgatggtggt     1020

ttacaggcta acccagtaga ggtgcaaagt taccagccgc cctggaaagt actgagtgac     1080

ttcgccttgc aaagcgacat agatcagcct gcttttcagc aactggtcaa tttttcagaa     1140

ggaggaccag gctctaattc tactggcagt gaagtagcat cgatgtcctc gcagctccca     1200

gatacaccca acagcatggt agccagtcct attgaggcat gaggaacatt cattcagatg     1260

ttttgttttg ttttgttttg tttttttccc ctgttggaga aagtggg                   1307


<210>  17
<211>  349
<212>  PRT
<213>  Mus musculus

<400>  17

Met Gly Asp Met Gly Asp Pro Pro Lys Lys Lys Arg Leu Ile Ser Leu 
1               5                   10                  15      


Cys Val Gly Cys Gly Asn Gln Ile His Asp Gln Tyr Ile Leu Arg Val 
            20                  25                  30          


Ser Pro Asp Leu Glu Trp His Ala Ala Cys Leu Lys Cys Ala Glu Cys 
        35                  40                  45              


Asn Gln Tyr Leu Asp Glu Ser Cys Thr Cys Phe Val Arg Asp Gly Lys 
    50                  55                  60                  


Thr Tyr Cys Lys Arg Asp Tyr Ile Arg Leu Tyr Gly Ile Lys Cys Ala 
65                  70                  75                  80  


Lys Cys Ser Ile Gly Phe Ser Lys Asn Asp Phe Val Met Arg Ala Arg 
                85                  90                  95      


Ser Lys Val Tyr His Ile Glu Cys Phe Arg Cys Val Ala Cys Ser Arg 
            100                 105                 110         


Gln Leu Ile Pro Gly Asp Glu Phe Ala Leu Arg Glu Asp Gly Leu Phe 
        115                 120                 125             


Cys Arg Ala Asp His Asp Val Val Glu Arg Ala Ser Leu Gly Ala Gly 
    130                 135                 140                 


Asp Pro Leu Ser Pro Leu His Pro Ala Arg Pro Leu Gln Met Ala Ala 
145                 150                 155                 160 


Glu Pro Ile Ser Ala Arg Gln Pro Ala Leu Arg Pro His Val His Lys 
                165                 170                 175     


Gln Pro Glu Lys Thr Thr Arg Val Arg Thr Val Leu Asn Glu Lys Gln 
            180                 185                 190         


Leu His Thr Leu Arg Thr Cys Tyr Ala Ala Asn Pro Arg Pro Asp Ala 
        195                 200                 205             


Leu Met Lys Glu Gln Leu Val Glu Met Thr Gly Leu Ser Pro Arg Val 
    210                 215                 220                 


Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys Arg Ser 
225                 230                 235                 240 


Ile Met Met Lys Gln Leu Gln Gln Gln Gln Pro Asn Asp Lys Thr Asn 
                245                 250                 255     


Ile Gln Gly Met Thr Gly Thr Pro Met Val Ala Ala Ser Pro Glu Arg 
            260                 265                 270         


His Asp Gly Gly Leu Gln Ala Asn Pro Val Glu Val Gln Ser Tyr Gln 
        275                 280                 285             


Pro Pro Trp Lys Val Leu Ser Asp Phe Ala Leu Gln Ser Asp Ile Asp 
    290                 295                 300                 


Gln Pro Ala Phe Gln Gln Leu Val Asn Phe Ser Glu Gly Gly Pro Gly 
305                 310                 315                 320 


Ser Asn Ser Thr Gly Ser Glu Val Ala Ser Met Ser Ser Gln Leu Pro 
                325                 330                 335     


Asp Thr Pro Asn Ser Met Val Ala Ser Pro Ile Glu Ala 
            340                 345                 


