                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
      UNIVERSITY OF WASHINGTON
 
<120> EXTRACELLULAR VESICLE-BASED AGENTS AND METHODS FOR THE TREATMENT 
      OF NEUROPATHIC DISORDERS

<130> 048317-605001WO

<140> PCT/US2020/056092
<141> 2020-10-16

<150> 62/916,208
<151> 2019-10-16

<160> 12    

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown:
      miRNA-21 sequence

<400> 1
uagcuuauca gacugauguu ga                                                22


<210> 2
<211> 22
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown:
      miRNA-132 sequence

<400> 2
uaacagucua cagccauggu cg                                                22


<210> 3
<211> 21
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown:
      miRNA-9 sequence

<400> 3
uaaagcuaga uaaccgaaag u                                                 21


<210> 4
<211> 21
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown:
      miRNA-27a sequence

<400> 4
uucacagugg cuaaguuccg c                                                 21


<210> 5
<211> 23
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown:
      miRNA-221 sequence

<400> 5
agcuacauug ucugcugggu uuc                                               23


<210> 6
<211> 22
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown:
      miRNA-200a-3p sequence

<400> 6
uaacacuguc ugguaacgau gu                                                22


<210> 7
<211> 22
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown:
      miRNA-361 sequence

<400> 7
uuaucagaau cuccaggggu ac                                                22


<210> 8
<211> 22
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown:
      miRNA-274 sequence

<400> 8
gaaguuguuc gugguggauu cg                                                22


<210> 9
<211> 21
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown:
      miR-873a-5p sequence

<400> 9
gcaggaacuu gugagucucc u                                                 21


<210> 10
<211> 366
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      LAMP-2 sequence

<400> 10
Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu Glu Leu Asn 
            20                  25                  30          


Leu Thr Asp Ser Glu Asn Ala Thr Cys Leu Tyr Ala Lys Trp Gln Met 
        35                  40                  45              


Asn Phe Thr Val Arg Tyr Glu Thr Thr Asn Lys Thr Tyr Lys Thr Val 
    50                  55                  60                  


Thr Ile Ser Asp His Gly Thr Val Thr Tyr Asn Gly Ser Ile Cys Gly 
65                  70                  75                  80  


Asp Asp Gln Asn Gly Pro Lys Ile Ala Val Gln Phe Gly Pro Gly Phe 
                85                  90                  95      


Ser Trp Ile Ala Asn Phe Thr Lys Ala Ala Ser Thr Tyr Ser Ile Asp 
            100                 105                 110         


Ser Val Ser Phe Ser Tyr Asn Thr Gly Asp Asn Thr Thr Phe Pro Asp 
        115                 120                 125             


Ala Glu Asp Lys Gly Ile Leu Thr Val Asp Glu Leu Leu Ala Ile Arg 
    130                 135                 140                 


Ile Pro Leu Asn Asp Leu Phe Arg Cys Asn Ser Leu Ser Thr Leu Glu 
145                 150                 155                 160 


Lys Asn Asp Val Val Gln His Tyr Trp Asp Val Leu Val Gln Ala Phe 
                165                 170                 175     


Val Gln Asn Gly Thr Val Ser Thr Asn Glu Phe Leu Cys Asp Lys Asp 
            180                 185                 190         


Lys Thr Ser Thr Val Ala Pro Thr Ile His Thr Thr Val Pro Ser Pro 
        195                 200                 205             


Thr Thr Thr Pro Thr Pro Lys Glu Lys Pro Glu Ala Gly Thr Tyr Ser 
    210                 215                 220                 


Val Asn Asn Gly Asn Asp Thr Cys Leu Leu Ala Thr Met Gly Leu Gln 
225                 230                 235                 240 


Leu Asn Ile Thr Gln Asp Lys Val Ala Ser Val Ile Asn Ile Asn Pro 
                245                 250                 255     


Asn Thr Thr His Ser Thr Gly Ser Cys Arg Ser His Thr Ala Leu Leu 
            260                 265                 270         


Arg Leu Asn Ser Ser Thr Ile Lys Tyr Leu Asp Phe Val Phe Ala Val 
        275                 280                 285             


Lys Asn Glu Asn Arg Phe Tyr Leu Lys Glu Val Asn Ile Ser Met Tyr 
    290                 295                 300                 


Leu Val Asn Gly Ser Val Phe Ser Ile Ala Asn Asn Asn Leu Ser Tyr 
305                 310                 315                 320 


Trp Asp Ala Pro Leu Gly Ser Ser Tyr Met Cys Asn Lys Glu Gln Thr 
                325                 330                 335     


Val Ser Val Ser Gly Ala Phe Gln Ile Asn Thr Phe Asp Leu Arg Val 
            340                 345                 350         


Gln Pro Phe Asn Val Thr Gln Gly Lys Tyr Ser Thr Ala Gln 
        355                 360                 365     


<210> 11
<211> 29
<212> PRT
<213> Rabies lyssavirus

<400> 11
Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp 
1               5                   10                  15      


Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly 
            20                  25                  


<210> 12
<211> 7333
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
ccgccatgcc ggggttttac gagattgtga ttaaggtccc cagcgacctt gacgagcatc       60

tgcccggcat ttctgacagc tttgtgaact gggtggccga gaaggaatgg gagttgccgc      120

cagattctga catggatctg aatctgattg agcaggcacc cctgaccgtg gccgagaagc      180

tgcagcgcga ctttctgacg gaatggcgcc gtgtgagtaa ggccccggag gcccttttct      240

ttgtgcaatt tgagaaggga gagagctact tccacatgca cgtgctcgtg gaaaccaccg      300

gggtgaaatc catggttttg ggacgtttcc tgagtcagat tcgcgaaaaa ctgattcaga      360

gaatttaccg cgggatcgag ccgactttgc caaactggtt cgcggtcaca aagaccagaa      420

atggcgccgg aggcgggaac aaggtggtgg atgagtgcta catccccaat tacttgctcc      480

ccaaaaccca gcctgagctc cagtgggcgt ggactaatat ggaacagtat ttaagcgcct      540

gtttgaatct cacggagcgt aaacggttgg tggcgcagca tctgacgcac gtgtcgcaga      600

cgcaggagca gaacaaagag aatcagaatc ccaattctga tgcgccggtg atcagatcaa      660

aaacttcagc caggtacatg gagctggtcg ggtggctcgt ggacaagggg attacctcgg      720

agaagcagtg gatccaggag gaccaggcct catacatctc cttcaatgcg gcctccaact      780

cgcggtccca aatcaaggct gccttggaca atgcgggaaa gattatgagc ctgactaaaa      840

ccgcccccga ctacctggtg ggccagcagc ccgtggagga catttccagc aatcggattt      900

ataaaatttt ggaactaaac gggtacgatc cccaatatgc ggcttccgtc tttctgggat      960

gggccacgaa aaagttcggc aagaggaaca ccatctggct gtttgggcct gcaactaccg     1020

ggaagaccaa catcgcggag gccatagccc acactgtgcc cttctacggg tgcgtaaact     1080

ggaccaatga gaactttccc ttcaacgact gtgtcgacaa gatggtgatc tggtgggagg     1140

aggggaagat gaccgccaag gtcgtggagt cggccaaagc cattctcgga ggaagcaagg     1200

tgcgcgtgga ccagaaatgc aagtcctcgg cccagataga cccgactccc gtgatcgtca     1260

cctccaacac caacatgtgc gccgtgattg acgggaactc aacgaccttc gaacaccagc     1320

agccgttgca agaccggatg ttcaaatttg aactcacccg ccgtctggat catgactttg     1380

ggaaggtcac caagcaggaa gtcaaagact ttttccggtg ggcaaaggat cacgtggttg     1440

aggtggagca tgaattctac gtcaaaaagg gtggagccaa gaaaagaccc gcccccagtg     1500

acgcagatat aagtgagccc aaacgggtgc gcgagtcagt tgcgcagcca tcgacgtcag     1560

acgcggaagc ttcgatcaac tacgcagaca ggtaccaaaa caaatgttct cgtcacgtgg     1620

gcatgaatct gatgctgttt ccctgcagac aatgcgagag aatgaatcag aattcaaata     1680

tctgcttcac tcacggacag aaagactgtt tagagtgctt tcccgtgtca gaatctcaac     1740

ccgtttctgt cgtcaaaaag gcgtatcaga aactgtgcta cattcatcat atcatgggaa     1800

aggtgccaga cgcttgcact gcctgcgatc tggtcaatgt ggatttggat gactgcatct     1860

ttgaacaata aatgatttaa atcaggtatg gctgccgatg gttatcttcc agattggctc     1920

gaggacactc tctctgaagg aataagacag tggtggaagc tcaaacctgg cccaccacca     1980

ccaaagcccg cagagcggca taaggacgac agcaggggtc ttgtgcttcc tgggtacaag     2040

tacctcggac ccttcaacgg actcgacaag ggagagccgg tcaacgaggc agacgccgcg     2100

gccctcgagc acgacaaagc ctacgaccgg cagctcgaca gcggagacaa cccgtacctc     2160

aagtacaacc acgccgacgc cgagttccag gagcggctca aagaagatac gtcttttggg     2220

ggcaacctcg ggcgagcagt cttccaggcc aaaaagaggc ttcttgaacc tcttggtctg     2280

gttgaggaag cggctaagac ggctcctgga aagaagaggc ctgtagagca ctctcctgtg     2340

gagccagact cctcctcggg aaccggaaag gcgggccagc agcctgcaag aaaaagattg     2400

aattttggtc agactggaga cgcagactca gtcccagacc ctcaaccaat cggagaacct     2460

cccgcagccc cctcaggtgt gggatctctt acaatggctg caggcggtgg cgcaccaatg     2520

gcagacaata acgagggcgc cgacggagtg ggtaattcct cgggaaattg gcattgcgat     2580

tccacatgga tgggcgacag agtcatcacc accagcaccc gaacctgggc cctgcccacc     2640

tacaacaacc acctctacaa gcaaatctcc aacagcacat ctggaggatc ttcaaatgac     2700

aacgcctact tcggctacag caccccctgg gggtattttg actttaacag attccactgc     2760

cacttttcac cacgtgactg gcagcgactc atcaacaaca actggggatt ccggcccaag     2820

agactcagct tcaagctctt caacatccag gtcaaggagg tcacgcagaa tgaaggcacc     2880

aagaccatcg ccaataacct caccagcacc atccaggtgt ttacggactc ggagtaccag     2940

ctgccgtacg ttctcggctc tgcccaccag ggctgcctgc ctccgttccc ggcggacgtg     3000

ttcatgattc cccagtacgg ctacctaaca ctcaacaacg gtagtcaggc cgtgggacgc     3060

tcctccttct actgcctgga atactttcct tcgcagatgc tgagaaccgg caacaacttc     3120

cagtttactt acaccttcga ggacgtgcct ttccacagca gctacgccca cagccagagc     3180

ttggaccggc tgatgaatcc tctgattgac cagtacctgt actacttgtc tcggactcaa     3240

acaacaggag gcacgacaaa tacgcagact ctgggcttca gccaaggtgg gcctaataca     3300

atggccaatc aggcaaagaa ctggctgcca ggaccctgtt accgccagca gcgagtatca     3360

aagacatctg cggataacaa caacagtgaa tactcgtgga ctggagctac caagtaccac     3420

ctcaatggca gagactctct ggtgaatccg ggcccggcca tggcaagcca caaggacgat     3480

gaagaaaagt tttttcctca gagcggggtt ctcatctttg ggaagcaagg ctcagagaaa     3540

acaaatgtgg acattgaaaa ggtcatgatt acagacgaag aggaaatcag gacaaccaat     3600

cccgtggcta cggagcagta tggttctgta tctaccaacc tccagcaagg caacacacaa     3660

gcagctaccg cagatgtcaa cacacaaggc gttcttccag gcatggtctg gcaggacaga     3720

gatgtgtacc ttcaggggcc catctgggca aagattccac acacggacgg acattttcac     3780

ccctctcccc tcatgggtgg attcggactt aaacaccctc cgcctcagat cctgatcaag     3840

aacacgcctg tacctgcgga tcctccgacc accttcaacc agtcaaagct gaactctttc     3900

atcacccagt attctactgg ccaagtcagc gtggagatcg agtgggagct gcagaaggaa     3960

aacagcaagc gctggaaccc cgagatccag tacacctcca actactacaa atctacaagt     4020

gtggactttg ctgttaatac agaaggcgtg tactctgaac cccgccccat tggcacccgt     4080

tacctcaccc gtaatctgta attgcctgtt aatcaataaa ccggttgatt cgtttcagtt     4140

gaactttggt ctctgcgaag ggcgaattcg tttaaacctg caggactaga ggtcctgtat     4200

tagaggtcac gtgagtgttt tgcgacattt tgcgacacca tgtggtcacg ctgggtattt     4260

aagcccgagt gagcacgcag ggtctccatt ttgaagcggg aggtttgaac gcgcagccgc     4320

caagccgaat tctgcagata tccatcacac tggcggccgc tcgactagag cggccgccac     4380

cgcggtggag ctccagcttt tgttcccttt agtgagggtt aattgcgcgc ttggcgtaat     4440

catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca cacaacatac     4500

gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa ctcacattaa     4560

ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag ctgcattaat     4620

gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc     4680

tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg     4740

cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag     4800

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc     4860

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag     4920

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga     4980

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc     5040

atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg     5100

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt     5160

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca     5220

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca     5280

ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag     5340

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca     5400

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg     5460

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa     5520

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta     5580

tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag     5640

cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga     5700

tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac     5760

cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc     5820

ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta     5880

gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac     5940

gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat     6000

gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa     6060

gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg     6120

tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag     6180

aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc     6240

cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct     6300

caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat     6360

cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg     6420

ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc     6480

aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta     6540

tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctaaat     6600

tgtaagcgtt aatattttgt taaaattcgc gttaaatttt tgttaaatca gctcattttt     6660

taaccaatag gccgaaatcg gcaaaatccc ttataaatca aaagaataga ccgagatagg     6720

gttgagtgtt gttccagttt ggaacaagag tccactatta aagaacgtgg actccaacgt     6780

caaagggcga aaaaccgtct atcagggcga tggcccacta cgtgaaccat caccctaatc     6840

aagttttttg gggtcgaggt gccgtaaagc actaaatcgg aaccctaaag ggagcccccg     6900

atttagagct tgacggggaa agccggcgaa cgtggcgaga aaggaaggga agaaagcgaa     6960

aggagcgggc gctagggcgc tggcaagtgt agcggtcacg ctgcgcgtaa ccaccacacc     7020

cgccgcgctt aatgcgccgc tacagggcgc gtcccattcg ccattcaggc tgcgcaactg     7080

ttgggaaggg cgatcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg     7140

tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac     7200

gacggccagt gagcgcgcgt aatacgactc actatagggc gaattgggta ccgggccccc     7260

cctcgatcga ggtcgacggt atcgggggag ctcgcagggt ctccattttg aagcgggagg     7320

tttgaacgcg cag                                                        7333


