                         SEQUENCE LISTING

<110>  National health research institutes
 
<120>  Use of succinate as biomarker in diagnosis and treatment of 
       cancers

<130>  P200025-US-PCT

<150>  US 62/916,376
<151>  2019-10-17

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of 6G10F6 Antibody

<400>  1
atgagagtgc tgattctttt gtggctgttc acagcctttc ctggtatcct gtctgatgtg       60

cagcttcagg agtcgggacc tggcctggtg aaaccttctc agtctctgtc cctcacctgc      120

actgtcactg gctactcaat caccagtgat tatgcctgga actggttccg gcagtttcca      180

ggaaacaaac tggagtggat gggctacaca agctacagtg gtagcactag ctataaccca      240

tctctcaaaa gtcgaatctc tatcactcga aacacatcca agaaccagat cttcctgcag      300

ttgaattctg tgactcctga ggacacagcc acatattact gtgcaagaga ggttactacg      360

tttggatact ttgactactg gggccaaggc accactctca cagtctcctc a               411


<210>  2
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of 6G10F6 Antibody

<400>  2

Met Arg Val Leu Ile Leu Leu Trp Leu Phe Thr Ala Phe Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Asp Tyr Ala Trp Asn Trp Phe Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Thr Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asn Thr Ser Lys Asn Gln 
                85                  90                  95      


Ile Phe Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Val Thr Thr Phe Gly Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135         


<210>  3
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of 6G10F6 antibody

<400>  3
atggcctgga cttcacttat actctctctc ctggctctct gctcaggagc cagttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtggaacagt catactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccagca accgagctcc aggtgttcct      240

gtcagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg atgcaatgta tttctgtgct ctatggtaca gcacccatta tgttctcggc      360

ggtggaacca aggtcactgt ccta                                             384


<210>  4
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of 6G10F6 antibody

<400>  4

Met Ala Trp Thr Ser Leu Ile Leu Ser Leu Leu Ala Leu Cys Ser Gly 
1               5                   10                  15      


Ala Ser Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Ile Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Asp Ala Met Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Leu Gly Gly Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


<210>  5
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain of 6G10G5 antibody

<400>  5
atgagagtgc tgattctttt gtggctgttc acagcctttc ctggtatcct gtctgatgtg       60

cagcttcagg agtcgggacc tggcctggtg aaaccttctc agtctctgtc cctcacctgc      120

actgtcactg gctactcaat caccagtgat tatgcctgga actggttccg gcagtttcca      180

ggaaacaaac tggagtggat gggctacaca agctacagtg gtagcactag ctataaccca      240

tctctcaaaa gtcgaatctc tatcactcga aacacatcca agaaccagat cttcctgcag      300

ttgaattctg tgactcctga ggacacagcc acatattact gtgcaagaga ggttactacg      360

tttggatact ttgactactg gggccaaggc accactctca cagtctcctc a               411


<210>  6
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of 6G10G5 antibody

<400>  6

Met Arg Val Leu Ile Leu Leu Trp Leu Phe Thr Ala Phe Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Asp Tyr Ala Trp Asn Trp Phe Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Thr Ser Tyr Ser Gly Ser Thr Ser Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asn Thr Ser Lys Asn Gln 
                85                  90                  95      


Ile Phe Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Val Thr Thr Phe Gly Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135         


<210>  7
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain of 6G10G5 antibody

<400>  7
atggcctgga cttcacttat actctctctc ctggctctct gctcaggagc cagttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtggaacagt catactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccagca accgagctcc aggtgttcct      240

gtcagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg atgcaatgta tttctgtgct ctatggtaca gcacccatta tgttctcggc      360

ggtggaacca aggtcactgt ccta                                             384


<210>  8
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of 6G10G5 antibody

<400>  8

Met Ala Trp Thr Ser Leu Ile Leu Ser Leu Leu Ala Leu Cys Ser Gly 
1               5                   10                  15      


Ala Ser Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Ile Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile 
                85                  90                  95      


Thr Gly Ala Gln Thr Glu Asp Asp Ala Met Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Leu Gly Gly Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


<210>  9
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH1 of the humanized 6G10F6 antibody

<400>  9

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Thr Ser Tyr Ser Gly Ser Thr Ser Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Val Thr Thr Phe Gly Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
225                 230                 235                 240 


Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys 
465 


<210>  10
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH2 of the humanized 6G10F6 antibody

<400>  10

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Thr Ser Tyr Ser Gly Ser Thr Ser Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Phe Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Val Thr Thr Phe Gly Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
225                 230                 235                 240 


Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys 
465 


<210>  11
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH3 of the humanized 6G10F6 antibody

<400>  11

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp Tyr Ala Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Lys 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Thr Ser Tyr Ser Gly Ser Thr Ser Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Ile Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Val Thr Thr Phe Gly Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
225                 230                 235                 240 


Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys 
465 


<210>  12
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH4 of the humanized 6G10F6 antibody

<400>  12

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp Tyr Ala Trp Asn Trp Phe Arg Gln Pro Pro Gly Lys Lys 
    50                  55                  60                  


Leu Glu Trp Met Gly Tyr Thr Ser Tyr Ser Gly Ser Thr Ser Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Val Thr Thr Phe Gly Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
225                 230                 235                 240 


Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys 
465 


<210>  13
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH5 of the humanized 6G10F6 antibody

<400>  13

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Thr Ser Tyr Ser Gly Ser Thr Ser Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Ile Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Val Thr Thr Phe Gly Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
225                 230                 235                 240 


Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    450                 455                 460                 


Lys 
465 


<210>  14
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL1 of the humanized 6G10F6 antibody

<400>  14

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Ala Leu Ile Tyr Gly Thr Ser Asn Arg Ala Pro Trp Thr Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  15
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL2 of the humanized 6G10F6 antibody

<400>  15

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Trp Thr Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  16
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL3 of the humanized 6G10F6 antibody

<400>  16

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  17
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL4 of the humanized 6G10F6 antibody

<400>  17

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly His Ala 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Trp Thr Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  18
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL5 of the humanized 6G10F6 antibody

<400>  18

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly His Ala 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Trp Thr Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  19
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL6 of the humanized 6G10F6 antibody

<400>  19

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Gly Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  20
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL7 of the humanized 6G10F6 antibody

<400>  20

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Phe Gln Gln Lys Pro Gly His Ala 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  21
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL8 of the humanized 6G10F6 antibody

<400>  21

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser 
            20                  25                  30          


Pro Gly Gly Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val 
        35                  40                  45              


Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Gly His Ala 
    50                  55                  60                  


Phe Thr Gly Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Leu Leu Gly Asp Lys Ala Ala Leu Thr Leu 
                85                  90                  95      


Ser Gly Val Gln Pro Glu Asp Glu Ala Glu Tyr Phe Cys Ala Leu Trp 
            100                 105                 110         


Tyr Ser Thr His Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        115                 120                 125             


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 


<210>  22
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH1 of the humanized 6G10F6 antibody

<400>  22
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

gtgcagctgc aggagtctgg accaggactg gtgaagccat cccagaccct gtctctgacc      120

tgcacagtgt ctggctacag catcacatcc gattatgcat ggaactggat caggcagcca      180

cctggcaagg gactggagtg gatcggctac acctcctatt ctggcagcac atcctacaac      240

ccctctctga agagcagagt gaccatcagc gtggacacat ccaagaatca gttcagcctg      300

aagctgagct ccgtgaccgc agcagataca gccgtgtact attgtgcccg ggaggtgacc      360

acattcggct actttgacta ttggggccag ggcaccctgg tgacagtgtc tagcgcctct      420

acaaagggcc ccagcgtttt cccactggct ccctgtagca gaagcaccag cgaatctaca      480

gccgctctgg gctgcctcgt gaaggactac tttcctgagc cagtgaccgt gtcctggaac      540

tctggcgctc tgacatctgg cgtgcacacc tttccagccg tgctgcaatc tagcggcctg      600

tactctctga gcagcgtggt cacagtgcct agctctagcc tgggcaccaa gacctacacc      660

tgtaatgtgg atcacaagcc cagcaacacc aaggtggaca agagagtgga atctaagtac      720

ggccctcctt gtcctagctg ccccgctcct gaatttctcg gcggaccttc cgtgttcctg      780

tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgcgtg      840

gtggtggacg tgtcccaaga ggatcctgag gtgcagttca attggtacgt ggacggcgtg      900

gaagtgcaca acgccaagac caagcctaga gaggaacagt tcaacagcac ctacagagtg      960

gtgtccgtgc tgacagtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag     1020

gtgtccaaca agggcctgcc tagcagcatc gagaaaacca tcagcaaggc caagggacag     1080

cccagggaac cccaggttta cacactgcct ccaagccaag aggaaatgac caagaatcag     1140

gtgtccctga cctgcctggt taagggcttc tacccctccg atatcgccgt ggaatgggag     1200

agcaatggcc agcctgagaa caactacaag acaacccctc ctgtgctgga cagcgacggc     1260

tcattcttcc tgtacagcag actgaccgtg gacaagtcca gatggcaaga gggcaacgtg     1320

ttctcctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtct     1380

ctgtccctgg gcaaatga                                                   1398


<210>  23
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH2 of the humanized 6G10F6 antibody

<400>  23
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

gtgcagctgc aggagtctgg accaggactg gtgaagccat cccagaccct gtctctgacc      120

tgcacagtgt ctggctacag catcacatcc gattatgcct ggaactggat caggcagcca      180

cctggcaagg gactggagtg gatcggctac acctcctatt ctggcagcac atcctacaac      240

ccctctctga agagccgggt gaccatcagc agagacacat ccaagaatca gttctttctg      300

aagctgagct ccgtgaccgc cgccgataca gccgtgtact attgtgcccg ggaggtgacc      360

acattcggct actttgacta ttggggccag ggcaccctgg tgacagtgtc tagcgcctct      420

acaaagggcc ccagcgtttt cccactggct ccctgtagca gaagcaccag cgaatctaca      480

gccgctctgg gctgcctcgt gaaggactac tttcctgagc cagtgaccgt gtcctggaac      540

tctggcgctc tgacatctgg cgtgcacacc tttccagccg tgctgcaatc tagcggcctg      600

tactctctga gcagcgtggt cacagtgcct agctctagcc tgggcaccaa gacctacacc      660

tgtaatgtgg atcacaagcc cagcaacacc aaggtggaca agagagtgga atctaagtac      720

ggccctcctt gtcctagctg ccccgctcct gaatttctcg gcggaccttc cgtgttcctg      780

tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgcgtg      840

gtggtggacg tgtcccaaga ggatcctgag gtgcagttca attggtacgt ggacggcgtg      900

gaagtgcaca acgccaagac caagcctaga gaggaacagt tcaacagcac ctacagagtg      960

gtgtccgtgc tgacagtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag     1020

gtgtccaaca agggcctgcc tagcagcatc gagaaaacca tcagcaaggc caagggacag     1080

cccagggaac cccaggttta cacactgcct ccaagccaag aggaaatgac caagaatcag     1140

gtgtccctga cctgcctggt taagggcttc tacccctccg atatcgccgt ggaatgggag     1200

agcaatggcc agcctgagaa caactacaag acaacccctc ctgtgctgga cagcgacggc     1260

tcattcttcc tgtacagcag actgaccgtg gacaagtcca gatggcaaga gggcaacgtg     1320

ttctcctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtct     1380

ctgtccctgg gcaaatga                                                   1398


<210>  24
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH3 of the humanized 6G10F6

<400>  24
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

gtgcagctgc aggagtctgg accaggactg gtgaagccat cccagaccct gtctctgacc      120

tgcacagtgt ctggctacag catcacatcc gattatgcct ggaactggtt caggcagccc      180

cctggcaaga agctggagtg gatgggctac acctcctatt ctggcagcac atcctacaac      240

ccctctctga agagccgggt gaccatcagc agagacacat ccaagaatca gatcagcctg      300

aagctgagct ccgtgaccgc agcagatacc gcaacatact attgtgcccg ggaggtgacc      360

acattcggct actttgacta ttggggccag ggcaccctgg tgacagtgtc tagcgcctct      420

acaaagggcc ccagcgtttt cccactggct ccctgtagca gaagcaccag cgaatctaca      480

gccgctctgg gctgcctcgt gaaggactac tttcctgagc cagtgaccgt gtcctggaac      540

tctggcgctc tgacatctgg cgtgcacacc tttccagccg tgctgcaatc tagcggcctg      600

tactctctga gcagcgtggt cacagtgcct agctctagcc tgggcaccaa gacctacacc      660

tgtaatgtgg atcacaagcc cagcaacacc aaggtggaca agagagtgga atctaagtac      720

ggccctcctt gtcctagctg ccccgctcct gaatttctcg gcggaccttc cgtgttcctg      780

tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgcgtg      840

gtggtggacg tgtcccaaga ggatcctgag gtgcagttca attggtacgt ggacggcgtg      900

gaagtgcaca acgccaagac caagcctaga gaggaacagt tcaacagcac ctacagagtg      960

gtgtccgtgc tgacagtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag     1020

gtgtccaaca agggcctgcc tagcagcatc gagaaaacca tcagcaaggc caagggacag     1080

cccagggaac cccaggttta cacactgcct ccaagccaag aggaaatgac caagaatcag     1140

gtgtccctga cctgcctggt taagggcttc tacccctccg atatcgccgt ggaatgggag     1200

agcaatggcc agcctgagaa caactacaag acaacccctc ctgtgctgga cagcgacggc     1260

tcattcttcc tgtacagcag actgaccgtg gacaagtcca gatggcaaga gggcaacgtg     1320

ttctcctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtct     1380

ctgtccctgg gcaaatga                                                   1398


<210>  25
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH4 of the humamized 6G10F6 antibody

<400>  25
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

gtgcagctgc aggagtctgg accaggactg gtgaagccat cccagaccct gtctctgacc      120

tgcacagtgt ctggctacag catcacatcc gattatgcat ggaactggtt caggcagcca      180

cctggcaaga agctggagtg gatgggctac acctcctatt ctggcagcac atcctacaac      240

ccctctctga agagcagagt gaccatcagc gtggacacat ccaagaatca gtttagcctg      300

aagctgagct ccgtgaccgc agcagataca gccgtgtact attgtgcccg ggaggtgacc      360

acattcggct actttgacta ttggggccag ggcaccctgg tgacagtgtc tagcgcctct      420

acaaagggcc ccagcgtttt cccactggct ccctgtagca gaagcaccag cgaatctaca      480

gccgctctgg gctgcctcgt gaaggactac tttcctgagc cagtgaccgt gtcctggaac      540

tctggcgctc tgacatctgg cgtgcacacc tttccagccg tgctgcaatc tagcggcctg      600

tactctctga gcagcgtggt cacagtgcct agctctagcc tgggcaccaa gacctacacc      660

tgtaatgtgg atcacaagcc cagcaacacc aaggtggaca agagagtgga atctaagtac      720

ggccctcctt gtcctagctg ccccgctcct gaatttctcg gcggaccttc cgtgttcctg      780

tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgcgtg      840

gtggtggacg tgtcccaaga ggatcctgag gtgcagttca attggtacgt ggacggcgtg      900

gaagtgcaca acgccaagac caagcctaga gaggaacagt tcaacagcac ctacagagtg      960

gtgtccgtgc tgacagtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag     1020

gtgtccaaca agggcctgcc tagcagcatc gagaaaacca tcagcaaggc caagggacag     1080

cccagggaac cccaggttta cacactgcct ccaagccaag aggaaatgac caagaatcag     1140

gtgtccctga cctgcctggt taagggcttc tacccctccg atatcgccgt ggaatgggag     1200

agcaatggcc agcctgagaa caactacaag acaacccctc ctgtgctgga cagcgacggc     1260

tcattcttcc tgtacagcag actgaccgtg gacaagtcca gatggcaaga gggcaacgtg     1320

ttctcctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtct     1380

ctgtccctgg gcaaatga                                                   1398


<210>  26
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH5 of the humanied 6G10F6

<400>  26
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

gtgcagctgc aggagtctgg accaggactg gtgaagccat cccagaccct gtctctgacc      120

tgcacagtgt ctggctacag catcacatcc gattatgcct ggaactggat caggcagcca      180

cctggcaagg gactggagtg gatcggctac acctcctatt ctggcagcac atcctacaac      240

ccctctctga agagccgggt gaccatcagc agagacacat ccaagaatca gatcagcctg      300

aagctgagct ccgtgaccgc agcagatacc gcaacatact attgtgcccg ggaggtgacc      360

acattcggct actttgacta ttggggccag ggcaccctgg tgacagtgtc tagcgcctct      420

acaaagggcc ccagcgtttt cccactggct ccctgtagca gaagcaccag cgaatctaca      480

gccgctctgg gctgcctcgt gaaggactac tttcctgagc cagtgaccgt gtcctggaac      540

tctggcgctc tgacatctgg cgtgcacacc tttccagccg tgctgcaatc tagcggcctg      600

tactctctga gcagcgtggt cacagtgcct agctctagcc tgggcaccaa gacctacacc      660

tgtaatgtgg atcacaagcc cagcaacacc aaggtggaca agagagtgga atctaagtac      720

ggccctcctt gtcctagctg ccccgctcct gaatttctcg gcggaccttc cgtgttcctg      780

tttcctccaa agcctaagga caccctgatg atcagcagaa cccctgaagt gacctgcgtg      840

gtggtggacg tgtcccaaga ggatcctgag gtgcagttca attggtacgt ggacggcgtg      900

gaagtgcaca acgccaagac caagcctaga gaggaacagt tcaacagcac ctacagagtg      960

gtgtccgtgc tgacagtgct gcaccaggat tggctgaacg gcaaagagta caagtgcaag     1020

gtgtccaaca agggcctgcc tagcagcatc gagaaaacca tcagcaaggc caagggacag     1080

cccagggaac cccaggttta cacactgcct ccaagccaag aggaaatgac caagaatcag     1140

gtgtccctga cctgcctggt taagggcttc tacccctccg atatcgccgt ggaatgggag     1200

agcaatggcc agcctgagaa caactacaag acaacccctc ctgtgctgga cagcgacggc     1260

tcattcttcc tgtacagcag actgaccgtg gacaagtcca gatggcaaga gggcaacgtg     1320

ttctcctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtct     1380

ctgtccctgg gcaaatga                                                   1398


<210>  27
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL1 of the humanized 6G10F6 antibody

<400>  27
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

acagtggtga cccaggagcc ttccctgaca gtgtctccag gcggcaccgt gacactgacc      120

tgcaggagct ccaccggagc agtgaccaca tctaactacg ccaattggtt ccagcagaag      180

ccaggacagg caccacgggc cctgatctat ggcacatcca acagggcacc atggacccct      240

gccagatttt ctggaagcct gctgggaggc aaggccgccc tgaccctgag cggcgtgcag      300

cccgaggacg aggccgagta ctattgtgcc ctgtggtact ccacacacta cgtgttcggc      360

acaggcacca aggtgaccgt gctgggacag cctaaggccg ctcctagcgt gacactgttt      420

cctccaagca gcgaggaact gcaggccaac aaagccacac tcgtgtgcct gatcagcgac      480

ttctatcccg gcgctgtgac agtggcctgg aaggctgata gctctcctgt gaaagccggc      540

gtggaaacca ccacacctag caagcagagc aacaacaaat acgccgccag cagctacctg      600

agcctgacac ctgagcagtg gaagtcccac agatcctaca gctgccaagt gacccacgag      660

ggcagcaccg tggaaaaaac agtggcccct accgagtgca gctga                      705


<210>  28
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL2 of the humanized 6G10F6 antibody

<400>  28
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

acagtggtga cccaggagcc ttccctgaca gtgtctccag gcggcaccgt gacactgacc      120

tgcaggagct ccaccggagc agtgaccaca tctaactacg ccaattggtt ccagcagaag      180

ccaggacagg caccaagggg actgatcgga ggcacatcca acagggcacc atggacccct      240

gccagatttt ctggaagcct gctgggaggc aaggccgccc tgaccctgag cggcgtgcag      300

cccgaggacg aggccgagta tttctgtgcc ctgtggtact ccacacacta cgtgttcggc      360

acaggcacca aggtgaccgt gctgggacag cctaaggccg ctcctagcgt gacactgttt      420

cctccaagca gcgaggaact gcaggccaac aaagccacac tcgtgtgcct gatcagcgac      480

ttctatcccg gcgctgtgac agtggcctgg aaggctgata gctctcctgt gaaagccggc      540

gtggaaacca ccacacctag caagcagagc aacaacaaat acgccgccag cagctacctg      600

agcctgacac ctgagcagtg gaagtcccac agatcctaca gctgccaagt gacccacgag      660

ggcagcaccg tggaaaaaac agtggcccct accgagtgca gctga                      705


<210>  29
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL3 of the humanized 6G10F6 antibody

<400>  29
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

acagtggtga cccaggagcc ttccctgaca gtgtctccag gcggcaccgt gacactgacc      120

tgcaggagct ccaccggagc agtgaccaca tctaactacg ccaattggtt ccagcagaag      180

ccaggacagg caccaagggg actgatcgga ggcacatcca acagggcacc aggagtgcct      240

gcaagatttt ctggaagcct gctgggcgac aaggccgccc tgaccctgag cggagtgcag      300

ccagaggatg aggccgagta tttctgtgcc ctgtggtact ccacacacta cgtgttcggc      360

acaggcacca aggtgaccgt gctgggacag cctaaggccg ctcctagcgt gacactgttt      420

cctccaagca gcgaggaact gcaggccaac aaagccacac tcgtgtgcct gatcagcgac      480

ttctatcccg gcgctgtgac agtggcctgg aaggctgata gctctcctgt gaaagccggc      540

gtggaaacca ccacacctag caagcagagc aacaacaaat acgccgccag cagctacctg      600

agcctgacac ctgagcagtg gaagtcccac agatcctaca gctgccaagt gacccacgag      660

ggcagcaccg tggaaaaaac agtggcccct accgagtgca gctga                      705


<210>  30
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL4 of the humanized 6G10F6 antibody

<400>  30
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

acagtggtga cccaggagcc atccctgaca gtgtctccag gaggaaccgt gacactgacc      120

tgccggagct ccaccggagc agtgaccaca tctaactacg ccaattggtt ccagcagaag      180

cctggccacg cctttacagg cctgatcgga ggcacctcca acagggcacc atggacacct      240

gccagattct ctggaagcct gctgggaggc aaggccgccc tgaccctgag cggcgtgcag      300

cccgaggacg aggccgagta tttctgtgcc ctgtggtact ccacacacta cgtgttcggc      360

acaggcacca aggtgaccgt gctgggacag cctaaggccg ctcctagcgt gacactgttt      420

cctccaagca gcgaggaact gcaggccaac aaagccacac tcgtgtgcct gatcagcgac      480

ttctatcccg gcgctgtgac agtggcctgg aaggctgata gctctcctgt gaaagccggc      540

gtggaaacca ccacacctag caagcagagc aacaacaaat acgccgccag cagctacctg      600

agcctgacac ctgagcagtg gaagtcccac agatcctaca gctgccaagt gacccacgag      660

ggcagcaccg tggaaaaaac agtggcccct accgagtgca gctga                      705


<210>  31
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL5 of the humanized 6G10F6 antibody

<400>  31
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

acagtggtga cccaggagcc atccctgaca gtgtctccag gaggaaccgt gacactgacc      120

tgccggagct ccaccggagc agtgaccaca tctaactacg ccaattgggt gcaggagaag      180

cctggacacg ccttcacagg actgatcgga ggcacctcca acagggcacc atggacacct      240

gccagatttt ctggaagcct gctgggaggc aaggccgccc tgaccctgag cggcgtgcag      300

cccgaggacg aggccgagta tttctgtgcc ctgtggtact ccacacacta cgtgttcggc      360

acaggcacca aggtgaccgt gctgggacag cctaaggccg ctcctagcgt gacactgttt      420

cctccaagca gcgaggaact gcaggccaac aaagccacac tcgtgtgcct gatcagcgac      480

ttctatcccg gcgctgtgac agtggcctgg aaggctgata gctctcctgt gaaagccggc      540

gtggaaacca ccacacctag caagcagagc aacaacaaat acgccgccag cagctacctg      600

agcctgacac ctgagcagtg gaagtcccac agatcctaca gctgccaagt gacccacgag      660

ggcagcaccg tggaaaaaac agtggcccct accgagtgca gctga                      705


<210>  32
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL6 of the humanized 6G10F6 antibody

<400>  32
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

acagtggtga cccaggagcc ttccctgaca gtgtctccag gcggcaccgt gacactgacc      120

tgcaggagct ccaccggagc agtgaccaca tctaactacg ccaattgggt gcaggagaag      180

ccaggacagg caccaagggg actgatcgga ggcacatcca accgggcccc cggcgtgcct      240

gccagattct ctggaagcct gctgggcgac aaggccgccc tgaccctgag cggagtgcag      300

ccagaggatg aggccgagta tttctgtgcc ctgtggtact ccacacacta cgtgttcggc      360

acaggcacca aggtgaccgt gctgggacag cctaaggccg ctcctagcgt gacactgttt      420

cctccaagca gcgaggaact gcaggccaac aaagccacac tcgtgtgcct gatcagcgac      480

ttctatcccg gcgctgtgac agtggcctgg aaggctgata gctctcctgt gaaagccggc      540

gtggaaacca ccacacctag caagcagagc aacaacaaat acgccgccag cagctacctg      600

agcctgacac ctgagcagtg gaagtcccac agatcctaca gctgccaagt gacccacgag      660

ggcagcaccg tggaaaaaac agtggcccct accgagtgca gctga                      705


<210>  33
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL7 of the humanized 6G10F6 antibody

<400>  33
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

acagtggtga cccaggagcc atccctgaca gtgtctccag gaggaaccgt gacactgacc      120

tgccggagct ccaccggagc agtgaccaca tctaactacg ccaattggtt ccagcagaag      180

cctggccacg cctttacagg cctgatcgga ggcacctcca acagggcacc aggagtgcct      240

gccagattct ctggaagcct gctgggcgac aaggccgccc tgaccctgag cggagtgcag      300

ccagaggatg aggccgagta tttctgtgcc ctgtggtact ccacacacta cgtgttcggc      360

acaggcacca aggtgaccgt gctgggacag cctaaggccg ctcctagcgt gacactgttt      420

cctccaagca gcgaggaact gcaggccaac aaagccacac tcgtgtgcct gatcagcgac      480

ttctatcccg gcgctgtgac agtggcctgg aaggctgata gctctcctgt gaaagccggc      540

gtggaaacca ccacacctag caagcagagc aacaacaaat acgccgccag cagctacctg      600

agcctgacac ctgagcagtg gaagtcccac agatcctaca gctgccaagt gacccacgag      660

ggcagcaccg tggaaaaaac agtggcccct accgagtgca gctga                      705


<210>  34
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL8 of the humanized antibody

<400>  34
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggcgt gcactctcag       60

acagtggtga cccaggagcc atccctgaca gtgtctccag gaggaaccgt gacactgacc      120

tgccggagct ccaccggagc agtgaccaca tctaactacg ccaattgggt gcaggagaag      180

cctggacacg ccttcacagg actgatcgga ggcacctcca acagggcacc aggagtgcct      240

gcaagatttt ctggaagcct gctgggcgac aaggccgccc tgaccctgag cggagtgcag      300

ccagaggatg aggccgagta tttctgtgcc ctgtggtact ccacacacta cgtgttcggc      360

acaggcacca aggtgaccgt gctgggacag cctaaggccg ctcctagcgt gacactgttt      420

cctccaagca gcgaggaact gcaggccaac aaagccacac tcgtgtgcct gatcagcgac      480

ttctatcccg gcgctgtgac agtggcctgg aaggctgata gctctcctgt gaaagccggc      540

gtggaaacca ccacacctag caagcagagc aacaacaaat acgccgccag cagctacctg      600

agcctgacac ctgagcagtg gaagtcccac agatcctaca gctgccaagt gacccacgag      660

ggcagcaccg tggaaaaaac agtggcccct accgagtgca gctga                      705


