                         SEQUENCE LISTING

<110>  University of Massachusetts
 
<120>  AAV PRODUCTION STRATEGY USING A CELL LINE EXPRESSING AN INDUCIBLE
        REP GENE

<130>  U0120.70132WO00

<140>  Not yet assigned
<141>  Concurrently herewith

<150>  US 63/010,719
<151>  2020-04-16

<150>  US 62/915,560
<151>  2019-10-15

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  1867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccagcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga ccagaaatgg      420

cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact tgctccccaa      480

aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa gcgcctgttt      540

gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt cgcagacgca      600

ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca gatcaaaaac      660

ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta cctcggagaa      720

gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct ccaactcgcg      780

gtcccaaatc aaggctgcct tggacaatgc gggaaagatt atgagcctga ctaaaaccgc      840

ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc ggatttataa      900

aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc tgggatgggc      960

cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa ctaccgggaa     1020

gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg taaactggac     1080

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt gggaggaggg     1140

gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa gcaaggtgcg     1200

cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga tcgtcacctc     1260

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc     1320

gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg actttgggaa     1380

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt     1440

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ccagtgacgc     1500

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc     1560

ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc acgtgggcat     1620

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt caaatatctg     1680

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacccgt     1740

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt     1800

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctttga     1860

acaataa                                                               1867


<210>  2
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Lys 
225                 230                 235                 240 


Gln Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala 
                245                 250                 255     


Ser Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys 
            260                 265                 270         


Ile Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln 
        275                 280                 285             


Pro Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu 
    290                 295                 300                 


Asn Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala 
305                 310                 315                 320 


Thr Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala 
                325                 330                 335     


Thr Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro 
            340                 345                 350         


Phe Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp 
        355                 360                 365             


Cys Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala 
    370                 375                 380                 


Lys Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg 
385                 390                 395                 400 


Val Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val 
                405                 410                 415     


Ile Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser 
            420                 425                 430         


Thr Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe 
        435                 440                 445             


Glu Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln 
    450                 455                 460                 


Glu Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val 
465                 470                 475                 480 


Glu His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala 
                485                 490                 495     


Pro Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val 
            500                 505                 510         


Ala Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp 
        515                 520                 525             


Arg Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu 
    530                 535                 540                 


Phe Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys 
545                 550                 555                 560 


Phe Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu 
                565                 570                 575     


Ser Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr 
            580                 585                 590         


Ile His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp 
        595                 600                 605             


Leu Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620     


<210>  3
<211>  1867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccagcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga ccagaaatgg      420

cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact tgctccccaa      480

aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa gcgcctgttt      540

gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt cgcagacgca      600

ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca gatcaaaaac      660

ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta cctaggagaa      720

gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct ccaactcgcg      780

gtcccaaatc aaggctgcct tggacaatgc gggaaagatt atgagcctga ctaaaaccgc      840

ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc ggatttataa      900

aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc tgggatgggc      960

cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa ctaccgggaa     1020

gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg taaactggac     1080

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt gggaggaggg     1140

gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa gcaaggtgcg     1200

cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga tcgtcacctc     1260

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc     1320

gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg actttgggaa     1380

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt     1440

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ccagtgacgc     1500

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc     1560

ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc acgtgggcat     1620

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt caaatatctg     1680

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacccgt     1740

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt     1800

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctttga     1860

acaataa                                                               1867


<210>  4
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Glu Lys Gln 
225                 230                 235                 240 


Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser 
                245                 250                 255     


Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile 
            260                 265                 270         


Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro 
        275                 280                 285             


Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn 
    290                 295                 300                 


Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr 
305                 310                 315                 320 


Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr 
                325                 330                 335     


Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe 
            340                 345                 350         


Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys 
        355                 360                 365             


Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys 
    370                 375                 380                 


Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val 
385                 390                 395                 400 


Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile 
                405                 410                 415     


Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr 
            420                 425                 430         


Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu 
        435                 440                 445             


Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu 
    450                 455                 460                 


Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val Glu 
465                 470                 475                 480 


His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro 
                485                 490                 495     


Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala 
            500                 505                 510         


Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg 
        515                 520                 525             


Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu Phe 
    530                 535                 540                 


Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe 
545                 550                 555                 560 


Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser 
                565                 570                 575     


Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile 
            580                 585                 590         


His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu 
        595                 600                 605             


Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620 


<210>  5
<211>  1867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
atgccggggt tttacgagat tgtgattaag gtcccctagg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccagcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga ccagaaatgg      420

cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact tgctccccaa      480

aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa gcgcctgttt      540

gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt cgcagacgca      600

ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca gatcaaaaac      660

ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta cctaggagaa      720

gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct ccaactcgcg      780

gtcccaaatc aaggctgcct tggacaatgc gggaaagatt atgagcctga ctaaaaccgc      840

ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc ggatttataa      900

aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc tgggatgggc      960

cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa ctaccgggaa     1020

gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg taaactggac     1080

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt gggaggaggg     1140

gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa gcaaggtgcg     1200

cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga tcgtcacctc     1260

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc     1320

gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg actttgggaa     1380

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt     1440

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ccagtgacgc     1500

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc     1560

ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc acgtgggcat     1620

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt caaatatctg     1680

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacccgt     1740

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt     1800

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctttga     1860

acaataa                                                               1867


<210>  6
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Asp Leu Asp Glu 
1               5                   10                  15      


His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys 
            20                  25                  30          


Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu 
        35                  40                  45              


Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr 
    50                  55                  60                  


Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln 
65                  70                  75                  80  


Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu Thr 
                85                  90                  95      


Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg 
            100                 105                 110         


Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro 
        115                 120                 125             


Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn 
    130                 135                 140                 


Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr 
145                 150                 155                 160 


Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser 
                165                 170                 175     


Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu 
            180                 185                 190         


Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro 
        195                 200                 205             


Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met 
    210                 215                 220                 


Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Glu Lys Gln Trp 
225                 230                 235                 240 


Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn 
                245                 250                 255     


Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met 
            260                 265                 270         


Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val 
        275                 280                 285             


Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly 
    290                 295                 300                 


Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys 
305                 310                 315                 320 


Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr 
                325                 330                 335     


Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr 
            340                 345                 350         


Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val 
        355                 360                 365             


Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val 
    370                 375                 380                 


Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp 
385                 390                 395                 400 


Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val 
                405                 410                 415     


Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr 
            420                 425                 430         


Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu 
        435                 440                 445             


Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val 
    450                 455                 460                 


Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val Glu His 
465                 470                 475                 480 


Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser 
                485                 490                 495     


Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln 
            500                 505                 510         


Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr 
        515                 520                 525             


Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro 
    530                 535                 540                 


Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr 
545                 550                 555                 560 


His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln 
                565                 570                 575     


Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His 
            580                 585                 590         


His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val 
        595                 600                 605             


Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 


<210>  7
<211>  1867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
atgccggggt tttacgagat tgtgattaag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccagcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga ccagaaatgg      420

cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact tgctccccaa      480

aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa gcgcctgttt      540

gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt cgcagacgca      600

ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca gatcaaaaac      660

ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta cctcggagta      720

gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct ccaactcgcg      780

gtcccaaatc aaggctgcct tggacaatgc gggaaagatt atgagcctga ctaaaaccgc      840

ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc ggatttataa      900

aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc tgggatgggc      960

cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa ctaccgggaa     1020

gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg taaactggac     1080

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt gggaggaggg     1140

gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa gcaaggtgcg     1200

cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga tcgtcacctc     1260

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc     1320

gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg actttgggaa     1380

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt     1440

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ccagtgacgc     1500

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc     1560

ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc acgtgggcat     1620

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt caaatatctg     1680

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacccgt     1740

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt     1800

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctttga     1860

acaataa                                                               1867


<210>  8
<211>  620
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Ser Asp Leu Asp 
1               5                   10                  15      


Glu His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu 
            20                  25                  30          


Lys Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile 
        35                  40                  45              


Glu Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu 
    50                  55                  60                  


Thr Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val 
65                  70                  75                  80  


Gln Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu 
                85                  90                  95      


Thr Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile 
            100                 105                 110         


Arg Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu 
        115                 120                 125             


Pro Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly 
    130                 135                 140                 


Asn Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys 
145                 150                 155                 160 


Thr Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu 
                165                 170                 175     


Ser Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His 
            180                 185                 190         


Leu Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn 
        195                 200                 205             


Pro Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr 
    210                 215                 220                 


Met Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Gln 
225                 230                 235                 240 


Trp Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser 
                245                 250                 255     


Asn Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile 
            260                 265                 270         


Met Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro 
        275                 280                 285             


Val Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn 
    290                 295                 300                 


Gly Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr 
305                 310                 315                 320 


Lys Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr 
                325                 330                 335     


Thr Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe 
            340                 345                 350         


Tyr Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys 
        355                 360                 365             


Val Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys 
    370                 375                 380                 


Val Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val 
385                 390                 395                 400 


Asp Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile 
                405                 410                 415     


Val Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr 
            420                 425                 430         


Thr Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu 
        435                 440                 445             


Leu Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu 
    450                 455                 460                 


Val Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val Glu 
465                 470                 475                 480 


His Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro 
                485                 490                 495     


Ser Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala 
            500                 505                 510         


Gln Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg 
        515                 520                 525             


Tyr Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu Phe 
    530                 535                 540                 


Pro Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe 
545                 550                 555                 560 


Thr His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser 
                565                 570                 575     


Gln Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile 
            580                 585                 590         


His His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu 
        595                 600                 605             


Val Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 620 


<210>  9
<211>  1867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
atgccggggt tttacgagat tgtgatttag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccagcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga ccagaaatgg      420

cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact tgctccccaa      480

aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa gcgcctgttt      540

gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt cgcagacgca      600

ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca gatcaaaaac      660

ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta cctcggagta      720

gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct ccaactcgcg      780

gtcccaaatc aaggctgcct tggacaatgc gggaaagatt atgagcctga ctaaaaccgc      840

ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc ggatttataa      900

aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc tgggatgggc      960

cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa ctaccgggaa     1020

gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg taaactggac     1080

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt gggaggaggg     1140

gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa gcaaggtgcg     1200

cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga tcgtcacctc     1260

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc     1320

gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg actttgggaa     1380

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt     1440

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ccagtgacgc     1500

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc     1560

ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc acgtgggcat     1620

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt caaatatctg     1680

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacccgt     1740

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt     1800

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctttga     1860

acaataa                                                               1867


<210>  10
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Pro Gly Phe Tyr Glu Ile Val Ile Val Pro Ser Asp Leu Asp Glu 
1               5                   10                  15      


His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys 
            20                  25                  30          


Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu 
        35                  40                  45              


Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr 
    50                  55                  60                  


Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln 
65                  70                  75                  80  


Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu Thr 
                85                  90                  95      


Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg 
            100                 105                 110         


Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro 
        115                 120                 125             


Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn 
    130                 135                 140                 


Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr 
145                 150                 155                 160 


Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser 
                165                 170                 175     


Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu 
            180                 185                 190         


Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro 
        195                 200                 205             


Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met 
    210                 215                 220                 


Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Gln Trp 
225                 230                 235                 240 


Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn 
                245                 250                 255     


Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met 
            260                 265                 270         


Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val 
        275                 280                 285             


Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly 
    290                 295                 300                 


Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys 
305                 310                 315                 320 


Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr 
                325                 330                 335     


Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr 
            340                 345                 350         


Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val 
        355                 360                 365             


Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val 
    370                 375                 380                 


Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp 
385                 390                 395                 400 


Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val 
                405                 410                 415     


Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr 
            420                 425                 430         


Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu 
        435                 440                 445             


Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val 
    450                 455                 460                 


Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val Glu His 
465                 470                 475                 480 


Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser 
                485                 490                 495     


Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln 
            500                 505                 510         


Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr 
        515                 520                 525             


Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro 
    530                 535                 540                 


Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr 
545                 550                 555                 560 


His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln 
                565                 570                 575     


Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His 
            580                 585                 590         


His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val 
        595                 600                 605             


Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 


<210>  11
<211>  1867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
atgccggggt tttacgagat tgtgattaag gtcccctagg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccagcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga ccagaaatgg      420

cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact tgctccccaa      480

aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa gcgcctgttt      540

gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt cgcagacgca      600

ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca gatcaaaaac      660

ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta cctcggagta      720

gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct ccaactcgcg      780

gtcccaaatc aaggctgcct tggacaatgc gggaaagatt atgagcctga ctaaaaccgc      840

ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc ggatttataa      900

aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc tgggatgggc      960

cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa ctaccgggaa     1020

gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg taaactggac     1080

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt gggaggaggg     1140

gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa gcaaggtgcg     1200

cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga tcgtcacctc     1260

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc     1320

gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg actttgggaa     1380

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt     1440

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ccagtgacgc     1500

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc     1560

ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc acgtgggcat     1620

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt caaatatctg     1680

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacccgt     1740

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt     1800

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctttga     1860

acaataa                                                               1867


<210>  12
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Pro Gly Phe Tyr Glu Ile Val Ile Lys Val Pro Asp Leu Asp Glu 
1               5                   10                  15      


His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys 
            20                  25                  30          


Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu 
        35                  40                  45              


Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr 
    50                  55                  60                  


Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln 
65                  70                  75                  80  


Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu Thr 
                85                  90                  95      


Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg 
            100                 105                 110         


Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro 
        115                 120                 125             


Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn 
    130                 135                 140                 


Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr 
145                 150                 155                 160 


Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser 
                165                 170                 175     


Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu 
            180                 185                 190         


Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro 
        195                 200                 205             


Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met 
    210                 215                 220                 


Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Ser Glu Gln Trp 
225                 230                 235                 240 


Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn 
                245                 250                 255     


Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met 
            260                 265                 270         


Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val 
        275                 280                 285             


Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly 
    290                 295                 300                 


Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys 
305                 310                 315                 320 


Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr 
                325                 330                 335     


Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr 
            340                 345                 350         


Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val 
        355                 360                 365             


Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val 
    370                 375                 380                 


Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp 
385                 390                 395                 400 


Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val 
                405                 410                 415     


Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr 
            420                 425                 430         


Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu 
        435                 440                 445             


Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val 
    450                 455                 460                 


Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val Glu His 
465                 470                 475                 480 


Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser 
                485                 490                 495     


Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln 
            500                 505                 510         


Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr 
        515                 520                 525             


Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro 
    530                 535                 540                 


Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr 
545                 550                 555                 560 


His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln 
                565                 570                 575     


Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His 
            580                 585                 590         


His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val 
        595                 600                 605             


Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 


<210>  13
<211>  1867
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
atgccggggt tttacgagat tgtgatttag gtccccagcg accttgacga gcatctgccc       60

ggcatttctg acagctttgt gaactgggtg gccgagaagg aatgggagtt gccgccagat      120

tctgacatgg atctgaatct gattgagcag gcacccctga ccgtggccga gaagctgcag      180

cgcgactttc tgacggaatg gcgccgtgtg agtaaggccc cggaggctct tttctttgtg      240

caatttgaga agggagagag ctacttccac atgcacgtgc tcgtggaaac caccggggtg      300

aaatccatgg ttttgggacg tttcctgagt cagattcgcg aaaaactgat tcagagaatt      360

taccagcggg atcgagccga ctttgccaaa ctggttcgcg gtcacaaaga ccagaaatgg      420

cgccggaggc gggaacaagg tggtggatga gtgctacatc cccaattact tgctccccaa      480

aacccagcct gagctccagt gggcgtggac taatatggaa cagtatttaa gcgcctgttt      540

gaatctcacg gagcgtaaac ggttggtggc gcagcatctg acgcacgtgt cgcagacgca      600

ggagcagaac aaagagaatc agaatcccaa ttctgatgcg ccggtgatca gatcaaaaac      660

ttcagccagg tacatggagc tggtcgggtg gctcgtggac aaggggatta cctaggagaa      720

gcagtggatc caggaggacc aggcctcata catctccttc aatgcggcct ccaactcgcg      780

gtcccaaatc aaggctgcct tggacaatgc gggaaagatt atgagcctga ctaaaaccgc      840

ccccgactac ctggtgggcc agcagcccgt ggaggacatt tccagcaatc ggatttataa      900

aattttggaa ctaaacgggt acgatcccca atatgcggct tccgtctttc tgggatgggc      960

cacgaaaaag ttcggcaaga ggaacaccat ctggctgttt gggcctgcaa ctaccgggaa     1020

gaccaacatc gcggaggcca tagcccacac tgtgcccttc tacgggtgcg taaactggac     1080

caatgagaac tttcccttca acgactgtgt cgacaagatg gtgatctggt gggaggaggg     1140

gaagatgacc gccaaggtcg tggagtcggc caaagccatt ctcggaggaa gcaaggtgcg     1200

cgtggaccag aaatgcaagt cctcggccca gatagacccg actcccgtga tcgtcacctc     1260

caacaccaac atgtgcgccg tgattgacgg gaactcaacg accttcgaac accagcagcc     1320

gttgcaagac cggatgttca aatttgaact cacccgccgt ctggatcatg actttgggaa     1380

ggtcaccaag caggaagtca aagacttttt ccggtgggca aaggatcacg tggttgaggt     1440

ggagcatgaa ttctacgtca aaaagggtgg agccaagaaa agacccgccc ccagtgacgc     1500

agatataagt gagcccaaac gggtgcgcga gtcagttgcg cagccatcga cgtcagacgc     1560

ggaagcttcg atcaactacg cagacaggta ccaaaacaaa tgttctcgtc acgtgggcat     1620

gaatctgatg ctgtttccct gcagacaatg cgagagaatg aatcagaatt caaatatctg     1680

cttcactcac ggacagaaag actgtttaga gtgctttccc gtgtcagaat ctcaacccgt     1740

ttctgtcgtc aaaaaggcgt atcagaaact gtgctacatt catcatatca tgggaaaggt     1800

gccagacgct tgcactgcct gcgatctggt caatgtggat ttggatgact gcatctttga     1860

acaataa                                                               1867


<210>  14
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Met Pro Gly Phe Tyr Glu Ile Val Ile Val Pro Ser Asp Leu Asp Glu 
1               5                   10                  15      


His Leu Pro Gly Ile Ser Asp Ser Phe Val Asn Trp Val Ala Glu Lys 
            20                  25                  30          


Glu Trp Glu Leu Pro Pro Asp Ser Asp Met Asp Leu Asn Leu Ile Glu 
        35                  40                  45              


Gln Ala Pro Leu Thr Val Ala Glu Lys Leu Gln Arg Asp Phe Leu Thr 
    50                  55                  60                  


Glu Trp Arg Arg Val Ser Lys Ala Pro Glu Ala Leu Phe Phe Val Gln 
65                  70                  75                  80  


Phe Glu Lys Gly Glu Ser Tyr Phe His Met His Val Leu Val Glu Thr 
                85                  90                  95      


Thr Gly Val Lys Ser Met Val Leu Gly Arg Phe Leu Ser Gln Ile Arg 
            100                 105                 110         


Glu Lys Leu Ile Gln Arg Ile Tyr Arg Gly Ile Glu Pro Thr Leu Pro 
        115                 120                 125             


Asn Trp Phe Ala Val Thr Lys Thr Arg Asn Gly Ala Gly Gly Gly Asn 
    130                 135                 140                 


Lys Val Val Asp Glu Cys Tyr Ile Pro Asn Tyr Leu Leu Pro Lys Thr 
145                 150                 155                 160 


Gln Pro Glu Leu Gln Trp Ala Trp Thr Asn Met Glu Gln Tyr Leu Ser 
                165                 170                 175     


Ala Cys Leu Asn Leu Thr Glu Arg Lys Arg Leu Val Ala Gln His Leu 
            180                 185                 190         


Thr His Val Ser Gln Thr Gln Glu Gln Asn Lys Glu Asn Gln Asn Pro 
        195                 200                 205             


Asn Ser Asp Ala Pro Val Ile Arg Ser Lys Thr Ser Ala Arg Tyr Met 
    210                 215                 220                 


Glu Leu Val Gly Trp Leu Val Asp Lys Gly Ile Thr Glu Lys Gln Trp 
225                 230                 235                 240 


Ile Gln Glu Asp Gln Ala Ser Tyr Ile Ser Phe Asn Ala Ala Ser Asn 
                245                 250                 255     


Ser Arg Ser Gln Ile Lys Ala Ala Leu Asp Asn Ala Gly Lys Ile Met 
            260                 265                 270         


Ser Leu Thr Lys Thr Ala Pro Asp Tyr Leu Val Gly Gln Gln Pro Val 
        275                 280                 285             


Glu Asp Ile Ser Ser Asn Arg Ile Tyr Lys Ile Leu Glu Leu Asn Gly 
    290                 295                 300                 


Tyr Asp Pro Gln Tyr Ala Ala Ser Val Phe Leu Gly Trp Ala Thr Lys 
305                 310                 315                 320 


Lys Phe Gly Lys Arg Asn Thr Ile Trp Leu Phe Gly Pro Ala Thr Thr 
                325                 330                 335     


Gly Lys Thr Asn Ile Ala Glu Ala Ile Ala His Thr Val Pro Phe Tyr 
            340                 345                 350         


Gly Cys Val Asn Trp Thr Asn Glu Asn Phe Pro Phe Asn Asp Cys Val 
        355                 360                 365             


Asp Lys Met Val Ile Trp Trp Glu Glu Gly Lys Met Thr Ala Lys Val 
    370                 375                 380                 


Val Glu Ser Ala Lys Ala Ile Leu Gly Gly Ser Lys Val Arg Val Asp 
385                 390                 395                 400 


Gln Lys Cys Lys Ser Ser Ala Gln Ile Asp Pro Thr Pro Val Ile Val 
                405                 410                 415     


Thr Ser Asn Thr Asn Met Cys Ala Val Ile Asp Gly Asn Ser Thr Thr 
            420                 425                 430         


Phe Glu His Gln Gln Pro Leu Gln Asp Arg Met Phe Lys Phe Glu Leu 
        435                 440                 445             


Thr Arg Arg Leu Asp His Asp Phe Gly Lys Val Thr Lys Gln Glu Val 
    450                 455                 460                 


Lys Asp Phe Phe Arg Trp Ala Lys Asp His Val Val Glu Val Glu His 
465                 470                 475                 480 


Glu Phe Tyr Val Lys Lys Gly Gly Ala Lys Lys Arg Pro Ala Pro Ser 
                485                 490                 495     


Asp Ala Asp Ile Ser Glu Pro Lys Arg Val Arg Glu Ser Val Ala Gln 
            500                 505                 510         


Pro Ser Thr Ser Asp Ala Glu Ala Ser Ile Asn Tyr Ala Asp Arg Tyr 
        515                 520                 525             


Gln Asn Lys Cys Ser Arg His Val Gly Met Asn Leu Met Leu Phe Pro 
    530                 535                 540                 


Cys Arg Gln Cys Glu Arg Met Asn Gln Asn Ser Asn Ile Cys Phe Thr 
545                 550                 555                 560 


His Gly Gln Lys Asp Cys Leu Glu Cys Phe Pro Val Ser Glu Ser Gln 
                565                 570                 575     


Pro Val Ser Val Val Lys Lys Ala Tyr Gln Lys Leu Cys Tyr Ile His 
            580                 585                 590         


His Ile Met Gly Lys Val Pro Asp Ala Cys Thr Ala Cys Asp Leu Val 
        595                 600                 605             


Asn Val Asp Leu Asp Asp Cys Ile Phe Glu Gln 
    610                 615                 


<210>  15
<211>  8515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgtgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaacaaa aactcaaaat ttcttctata aagtaacaaa acttttatga      240

gggacagccc ccccccaaag cccccaggga tgtaattacg tccctccccc gctagggggc      300

agcagcgagc cgcccggggc tccgctccgg tccggcgctc cccccgcatc cccgagccgg      360

cagcgtgcgg ggacagcccg ggcacgggga aggtggcacg ggatcgcttt cctctgaacg      420

cttctcgctg ctctttgagc ctgcagacac ctggggggat acggggaaaa ggctagaggt      480

cctgtattag aggtcacgtg agtgttttgc gacattttgc gacaccatgt ggtcacgctg      540

ggtatttaag cccgagtgag cacgcagggt ctccattttg aagcgggagg tttgaacgcg      600

cagccgccaa gccgaattct gcagatatcc ccgagtcctt caatgctatc attccctttg      660

atattggacc atatgcatag taccgagaaa ctagtgcgaa gtagtgatca ggtattgctg      720

ttagatatcc ccgagtcctt caatgctatc attctctttg atattggacc atatgcatag      780

taccgagaaa ctagtgcgaa gtagtgatca ggtattgctg ttagatatcc ccgagtcctt      840

caatgctatc attccctttg atattggacc atatgcatag taccgagaaa ctagtgcgaa      900

gtagtgatca ggtattgctg ttagatatcc ccgagtcctt caatgctatc attctctttg      960

atattggacc atatgcatag taccgagaaa ctagtgcgaa gtagtgatca ggtattgctg     1020

ttagatatcc ccgagtcctt caatgctatc attccctttg atattggacc atatgcatag     1080

taccgagaaa ctagtgcgaa gtagtgatca ggtattgctg ttagatatcc ccgagtcctt     1140

caatgctatc atttcctttg atattggatc atatgcatag taccgagaaa ctagtgcgaa     1200

gtagtgatca ggtattgctg ttaaggatcc atcacactgg cggccgctcg aggggagctc     1260

gcagggtctc cattttgaag cgggaggttt gaacgcgcag ccgccatgcc ggggttttac     1320

gagattgtga ttaaggtccc cagcgacctt gacgagcatc tgcccggcat ttctgacagc     1380

tttgtgaact gggtggccga gaaggaatgg gagttgccgc cagattctga catggatctg     1440

aatctgattg agcaggcacc cctgaccgtg gccgagaagc tgcagcgcga ctttctgacg     1500

gaatggcgcc gtgtgagtaa ggccccggag gctcttttct ttgtgcaatt tgagaaggga     1560

gagagctact tccacatgca cgtgctcgtg gaaaccaccg gggtgaaatc catggttttg     1620

ggacgtttcc tgagtcagat tcgcgaaaaa ctgattcaga gaatttacca gcgggatcga     1680

gccgactttg ccaaactggt tcgcggtcac aaagaccaga aatggcgccg gaggcgggaa     1740

caaggtggtg gatgagtgct acatccccaa ttacttgctc cccaaaaccc agcctgagct     1800

ccagtgggcg tggactaata tggaacagta tttaagcgcc tgtttgaatc tcacggagcg     1860

taaacggttg gtggcgcagc atctgacgca cgtgtcgcag acgcaggagc agaacaaaga     1920

gaatcagaat cccaattctg atgcgccggt gatcagatca aaaacttcag ccaggtacat     1980

ggagctggtc gggtggctcg tggacaaggg gattacctag gagaagcagt ggatccagga     2040

ggaccaggcc tcatacatct ccttcaatgc ggcctccaac tcgcggtccc aaatcaaggc     2100

tgccttggac aatgcgggaa agattatgag cctgactaaa accgcccccg actacctggt     2160

gggccagcag cccgtggagg acatttccag caatcggatt tataaaattt tggaactaaa     2220

cgggtacgat ccccaatatg cggcttccgt ctttctggga tgggccacga aaaagttcgg     2280

caagaggaac accatctggc tgtttgggcc tgcaactacc gggaagacca acatcgcgga     2340

ggccatagcc cacactgtgc ccttctacgg gtgcgtaaac tggaccaatg agaactttcc     2400

cttcaacgac tgtgtcgaca agatggtgat ctggtgggag gaggggaaga tgaccgccaa     2460

ggtcgtggag tcggccaaag ccattctcgg aggaagcaag gtgcgcgtgg accagaaatg     2520

caagtcctcg gcccagatag acccgactcc cgtgatcgtc acctccaaca ccaacatgtg     2580

cgccgtgatt gacgggaact caacgacctt cgaacaccag cagccgttgc aagaccggat     2640

gttcaaattt gaactcaccc gccgtctgga tcatgacttt gggaaggtca ccaagcagga     2700

agtcaaagac tttttccggt gggcaaagga tcacgtggtt gaggtggagc atgaattcta     2760

cgtcaaaaag ggtggagcca agaaaagacc cgcccccagt gacgcagata taagtgagcc     2820

caaacgggtg cgcgagtcag ttgcgcagcc atcgacgtca gacgcggaag cttcgatcaa     2880

ctacgcagac aggtaccaaa acaaatgttc tcgtcacgtg ggcatgaatc tgatgctgtt     2940

tccctgcaga caatgcgaga gaatgaatca gaattcaaat atctgcttca ctcacggaca     3000

gaaagactgt ttagagtgct ttcccgtgtc agaatctcaa cccgtttctg tcgtcaaaaa     3060

ggcgtatcag aaactgtgct acattcatca tatcatggga aaggtgccag acgcttgcac     3120

tgcctgcgat ctggtcaatg tggatttgga tgactgcatc tttgaacaat aaatgattta     3180

aatcaggtat ggctgccgat ggttatcttc cagattggct cgaggacact ctctctgaag     3240

gaataagaca gtggtggaag ctcaaacctg gcccaccacc accaaagccc gcagagcggc     3300

ataaggacga cagcaggggt cttgtgcttc ctgggtacaa gtacctcgga cccttcaacg     3360

gactcgacaa gggagagccg gtcaacgagg cagacgccgc ggccctcgag cacgacaaag     3420

cctacgaccg gcagctcgac agcggagaca acccgtacct caagtacaac cacgccgacg     3480

cggagtttca ggagcgcctt aaagaagata cgtcttttgg gggcaacctc ggacgagcag     3540

tcttccaggc gaaaaagagg gttcttgaac ctctgggcct ggttgaggaa cctgttaaga     3600

cggctccggg aaaaaagagg ccggtagagc actctcctgt ggagccagac tcctcctcgg     3660

gaaccggaaa ggcgggccag cagcctgcaa gaaaaagatt gaattttggt cagactggag     3720

acgcagactc agtacctgac ccccagcctc tcggacagcc accagcagcc ccctctggtc     3780

tgggaactaa tacgatggct acaggcagtg gcgcaccaat ggcagacaat aacgagggcg     3840

ccgacggagt gggtaattcc tcgggaaatt ggcattgcga ttccacatgg atgggcgaca     3900

gagtcatcac caccagcacc cgaacctggg ccctgcccac ctacaacaac cacctctaca     3960

aacaaatttc cagccaatca ggagcctcga acgacaatca ctactttggc tacagcaccc     4020

cttgggggta ttttgacttc aacagattcc actgccactt ttcaccacgt gactggcaaa     4080

gactcatcaa caacaactgg ggattccgac ccaagagact caacttcaag ctctttaaca     4140

ttcaagtcaa agaggtcacg cagaatgacg gtacgacgac gattgccaat aaccttacca     4200

gcacggttca ggtgtttact gactcggagt accagctccc gtacgtcctc ggctcggcgc     4260

atcaaggatg cctcccgccg ttcccagcag acgtcttcat ggtgccacag tatggatacc     4320

tcaccctgaa caacgggagt caggcagtag gacgctcttc attttactgc ctggagtact     4380

ttccttctca gatgctgcgt accggaaaca actttacctt cagctacact tttgaggacg     4440

ttcctttcca cagcagctac gctcacagcc agagtctgga ccgtctcatg aatcctctca     4500

tcgaccagta cctgtattac ttgagcagaa caaacactcc aagtggaacc accacgcagt     4560

caaggcttca gttttctcag gccggagcga gtgacattcg ggaccagtct aggaactggc     4620

ttcctggacc ctgttaccgc cagcagcgag tatcaaagac atctgcggat aacaacaaca     4680

gtgaatactc gtggactgga gctaccaagt accacctcaa tggcagagac tctctggtga     4740

atccgggccc ggccatggca agccacaagg acgatgaaga aaagtttttt cctcagagcg     4800

gggttctcat ctttgggaag caaggctcag agaaaacaaa tgtggacatt gaaaaggtca     4860

tgattacaga cgaagaggaa atcaggacaa ccaatcccgt ggctacggag cagtatggtt     4920

ctgtatctac caacctccag agaggcaaca gacaagcagc taccgcagat gtcaacacac     4980

aaggcgttct tccaggcatg gtctggcagg acagagatgt gtaccttcag gggcccatct     5040

gggcaaagat tccacacacg gacggacatt ttcacccctc tcccctcatg ggtggattcg     5100

gacttaaaca ccctcctcca cagattctca tcaagaacac cccggtacct gcgaatcctt     5160

cgaccacctt cagtgcggca aagtttgctt ccttcatcac acagtactcc acgggacagg     5220

tcagcgtgga gatcgagtgg gagctgcaga aggaaaacag caaacgctgg aatcccgaaa     5280

ttcagtacac ttccaactac aacaagtctg ttaatgtgga ctttactgtg gacactaatg     5340

gcgtgtattc agagcctcgc cccattggca ccagatacct gactcgtaat ctgtaattgc     5400

ttgttaatca ataaaccgtt taattcgttt cagttgaact ttggtctctg cgtatttctt     5460

tcttatctag tttccatgct cctccacggc caaggatctg cgatcgctcc ggtgcccgtc     5520

agtgggcaga gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt     5580

gaacgggtgc ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc     5640

tccgcctttt tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg     5700

ttctttttcg caacgggttt gccgccagaa cacagctgaa gcttcgaggg gctcgcatct     5760

ctccttcacg cgcccgccgc cctacctgag gccgccatcc acgccggttg agtcgcgttc     5820

tgccgcctcc cgcctgtggt gcctcctgaa ctgcgtccgc cgtctaggta agtttaaagc     5880

tcaggtcgag accgggcctt tgtccggcgc tcccttggag cctacctaga ctcagccggc     5940

tctccacgct ttgcctgacc ctgcttgctc aactctacgt ctttgtttcg ttttctgttc     6000

tgcgccgtta cagatccaag ctgtgaccgg cgcctactct agagctagcg aattcgaatt     6060

taaatcggat ccgcggccgc gcccctctcc ctcccccccc cctaacgtta ctggccgaag     6120

ccgcttggaa taaggccggt gtgcgtttgt ctatatgtta ttttccacca tattgccgtc     6180

ttttggcaat gtgagggccc ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg     6240

tctttcccct ctcgccaaag gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc     6300

tctggaagct tcttgaagac aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc     6360

cccacctggc gacaggtgcc tctgcggcca aaagccacgt gtataagata cacctgcaaa     6420

ggcggcacaa ccccagtgcc acgttgtgag ttggatagtt gtggaaagag tcaaatggct     6480

ctcctcaagc gtattcaaca aggggctgaa ggatgcccag aaggtacccc attgtatggg     6540

atctgatctg gggcctcggt gcacatgctt tacatgtgtt tagtcgaggt taaaaaaacg     6600

tctaggcccc ccgaaccacg gggacgtggt tttcctttga aaaacacgat gataatatgg     6660

ccacaaccat ggcgtccgga atgattgaac aagatggatt gcacgcaggt tctccggccg     6720

cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc tgctctgatg     6780

ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag accgacctgt     6840

ccggtgccct gaatgaactg caggacgagg cagcgcggct atcgtggctg gccgcgacgg     6900

gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac tggctgctat     6960

tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc gagaaagtat     7020

ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc tgcccattcg     7080

accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg     7140

atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc     7200

tcaaggcgcg catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc     7260

cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc cggctgggtg     7320

tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa gagcttggcg     7380

gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca     7440

tcgccttcta tcgccttctt gacgagttct tctgagtcga caatcaacct ctggattaca     7500

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     7560

acgctgcttt aatgcctttg tatcatgcgt taactaaact tgtttattgc agcttataat     7620

ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat     7680

tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtctggaa ttgactcaaa     7740

tgatgtcaat tagtctatca gaagctcatc tggtctccct tccgggggac aagacatccc     7800

tgtttaatat ttaaacagca gtgttcccaa actgggttct tatatccctt gctctggtca     7860

accaggttgc agggtttcct gtcctcacag gaacgaagtc cctaaagaaa cagtggcagc     7920

caggtttagc cccggaattg actggattcc ttttttaggg cccattggta tggctttttc     7980

cccgtatccc cccaggtgtc tgcaggctca aagagcagcg agaagcgttc agaggaaagc     8040

gatcccgtgc caccttcccc gtgcccgggc tgtccccgca cgctgccggc tcggggatgc     8100

ggggggagcg ccggaccgga gcggagcccc gggcggctcg ctgctgcccc ctagcggggg     8160

agggacgtaa ttacatccct gggggctttg ggggggggct gtccctgata tctataacaa     8220

gaaaatatat atataataag ttatcacgta agtagaacat gaaataacaa tataattatc     8280

gtatgagtta aatcttaaaa gtcacgtaaa agataatcat gcgtcatttt gactcacgcg     8340

gtcgttatag ttcaaaatca gtgacactta ccgcattgac aagcacgcct cacgggagct     8400

ccaagcggcg actgagatgt cctaaatgca cagcgacgga ttcgcgctat ttagaaagag     8460

agagcaatat ttcaagaatg catgcgtcaa ttttacgcag actatctttc taggg          8515


<210>  16
<211>  7877
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgtgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaacaaa aactcaaaat ttcttctata aagtaacaaa acttttatga      240

gggacagccc ccccccaaag cccccaggga tgtaattacg tccctccccc gctagggggc      300

agcagcgagc cgcccggggc tccgctccgg tccggcgctc cccccgcatc cccgagccgg      360

cagcgtgcgg ggacagcccg ggcacgggga aggtggcacg ggatcgcttt cctctgaacg      420

cttctcgctg ctctttgagc ctgcagacac ctggggggat acggggaaaa ggctagaggt      480

cctgtattag aggtcacgtg agtgttttgc gacattttgc gacaccatgt ggtcacgctg      540

ggtatttaag cccgagtgag cacgcagggt ctccattttg aagcgaggat ccatcacact      600

ggcggccgct cgaggggagc tcgcagggtc tccattttga agcgggaggt ttgaacgcgc      660

agccgccatg ccggggtttt acgagattgt gattaaggtc cccagcgacc ttgacgagca      720

tctgcccggc atttctgaca gctttgtgaa ctgggtggcc gagaaggaat gggagttgcc      780

gccagattct gacatggatc tgaatctgat tgagcaggca cccctgaccg tggccgagaa      840

gctgcagcgc gactttctga cggaatggcg ccgtgtgagt aaggccccgg aggctctttt      900

ctttgtgcaa tttgagaagg gagagagcta cttccacatg cacgtgctcg tggaaaccac      960

cggggtgaaa tccatggttt tgggacgttt cctgagtcag attcgcgaaa aactgattca     1020

gagaatttac cagcgggatc gagccgactt tgccaaactg gttcgcggtc acaaagacca     1080

gaaatggcgc cggaggcggg aacaaggtgg tggatgagtg ctacatcccc aattacttgc     1140

tccccaaaac ccagcctgag ctccagtggg cgtggactaa tatggaacag tatttaagcg     1200

cctgtttgaa tctcacggag cgtaaacggt tggtggcgca gcatctgacg cacgtgtcgc     1260

agacgcagga gcagaacaaa gagaatcaga atcccaattc tgatgcgccg gtgatcagat     1320

caaaaacttc agccaggtac atggagctgg tcgggtggct cgtggacaag gggattacct     1380

aggagaagca gtggatccag gaggaccagg cctcatacat ctccttcaat gcggcctcca     1440

actcgcggtc ccaaatcaag gctgccttgg acaatgcggg aaagattatg agcctgacta     1500

aaaccgcccc cgactacctg gtgggccagc agcccgtgga ggacatttcc agcaatcgga     1560

tttataaaat tttggaacta aacgggtacg atccccaata tgcggcttcc gtctttctgg     1620

gatgggccac gaaaaagttc ggcaagagga acaccatctg gctgtttggg cctgcaacta     1680

ccgggaagac caacatcgcg gaggccatag cccacactgt gcccttctac gggtgcgtaa     1740

actggaccaa tgagaacttt cccttcaacg actgtgtcga caagatggtg atctggtggg     1800

aggaggggaa gatgaccgcc aaggtcgtgg agtcggccaa agccattctc ggaggaagca     1860

aggtgcgcgt ggaccagaaa tgcaagtcct cggcccagat agacccgact cccgtgatcg     1920

tcacctccaa caccaacatg tgcgccgtga ttgacgggaa ctcaacgacc ttcgaacacc     1980

agcagccgtt gcaagaccgg atgttcaaat ttgaactcac ccgccgtctg gatcatgact     2040

ttgggaaggt caccaagcag gaagtcaaag actttttccg gtgggcaaag gatcacgtgg     2100

ttgaggtgga gcatgaattc tacgtcaaaa agggtggagc caagaaaaga cccgccccca     2160

gtgacgcaga tataagtgag cccaaacggg tgcgcgagtc agttgcgcag ccatcgacgt     2220

cagacgcgga agcttcgatc aactacgcag acaggtacca aaacaaatgt tctcgtcacg     2280

tgggcatgaa tctgatgctg tttccctgca gacaatgcga gagaatgaat cagaattcaa     2340

atatctgctt cactcacgga cagaaagact gtttagagtg ctttcccgtg tcagaatctc     2400

aacccgtttc tgtcgtcaaa aaggcgtatc agaaactgtg ctacattcat catatcatgg     2460

gaaaggtgcc agacgcttgc actgcctgcg atctggtcaa tgtggatttg gatgactgca     2520

tctttgaaca ataaatgatt taaatcaggt atggctgccg atggttatct tccagattgg     2580

ctcgaggaca ctctctctga aggaataaga cagtggtgga agctcaaacc tggcccacca     2640

ccaccaaagc ccgcagagcg gcataaggac gacagcaggg gtcttgtgct tcctgggtac     2700

aagtacctcg gacccttcaa cggactcgac aagggagagc cggtcaacga ggcagacgcc     2760

gcggccctcg agcacgacaa agcctacgac cggcagctcg acagcggaga caacccgtac     2820

ctcaagtaca accacgccga cgcggagttt caggagcgcc ttaaagaaga tacgtctttt     2880

gggggcaacc tcggacgagc agtcttccag gcgaaaaaga gggttcttga acctctgggc     2940

ctggttgagg aacctgttaa gacggctccg ggaaaaaaga ggccggtaga gcactctcct     3000

gtggagccag actcctcctc gggaaccgga aaggcgggcc agcagcctgc aagaaaaaga     3060

ttgaattttg gtcagactgg agacgcagac tcagtacctg acccccagcc tctcggacag     3120

ccaccagcag ccccctctgg tctgggaact aatacgatgg ctacaggcag tggcgcacca     3180

atggcagaca ataacgaggg cgccgacgga gtgggtaatt cctcgggaaa ttggcattgc     3240

gattccacat ggatgggcga cagagtcatc accaccagca cccgaacctg ggccctgccc     3300

acctacaaca accacctcta caaacaaatt tccagccaat caggagcctc gaacgacaat     3360

cactactttg gctacagcac cccttggggg tattttgact tcaacagatt ccactgccac     3420

ttttcaccac gtgactggca aagactcatc aacaacaact ggggattccg acccaagaga     3480

ctcaacttca agctctttaa cattcaagtc aaagaggtca cgcagaatga cggtacgacg     3540

acgattgcca ataaccttac cagcacggtt caggtgttta ctgactcgga gtaccagctc     3600

ccgtacgtcc tcggctcggc gcatcaagga tgcctcccgc cgttcccagc agacgtcttc     3660

atggtgccac agtatggata cctcaccctg aacaacggga gtcaggcagt aggacgctct     3720

tcattttact gcctggagta ctttccttct cagatgctgc gtaccggaaa caactttacc     3780

ttcagctaca cttttgagga cgttcctttc cacagcagct acgctcacag ccagagtctg     3840

gaccgtctca tgaatcctct catcgaccag tacctgtatt acttgagcag aacaaacact     3900

ccaagtggaa ccaccacgca gtcaaggctt cagttttctc aggccggagc gagtgacatt     3960

cgggaccagt ctaggaactg gcttcctgga ccctgttacc gccagcagcg agtatcaaag     4020

acatctgcgg ataacaacaa cagtgaatac tcgtggactg gagctaccaa gtaccacctc     4080

aatggcagag actctctggt gaatccgggc ccggccatgg caagccacaa ggacgatgaa     4140

gaaaagtttt ttcctcagag cggggttctc atctttggga agcaaggctc agagaaaaca     4200

aatgtggaca ttgaaaaggt catgattaca gacgaagagg aaatcaggac aaccaatccc     4260

gtggctacgg agcagtatgg ttctgtatct accaacctcc agagaggcaa cagacaagca     4320

gctaccgcag atgtcaacac acaaggcgtt cttccaggca tggtctggca ggacagagat     4380

gtgtaccttc aggggcccat ctgggcaaag attccacaca cggacggaca ttttcacccc     4440

tctcccctca tgggtggatt cggacttaaa caccctcctc cacagattct catcaagaac     4500

accccggtac ctgcgaatcc ttcgaccacc ttcagtgcgg caaagtttgc ttccttcatc     4560

acacagtact ccacgggaca ggtcagcgtg gagatcgagt gggagctgca gaaggaaaac     4620

agcaaacgct ggaatcccga aattcagtac acttccaact acaacaagtc tgttaatgtg     4680

gactttactg tggacactaa tggcgtgtat tcagagcctc gccccattgg caccagatac     4740

ctgactcgta atctgtaatt gcttgttaat caataaaccg tttaattcgt ttcagttgaa     4800

ctttggtctc tgcgtatttc tttcttatct agtttccatg ctcctccacg gccaaggatc     4860

tgcgatcgct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag     4920

ttggggggag gggtcggcaa ttgaacgggt gcctagagaa ggtggcgcgg ggtaaactgg     4980

gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata     5040

agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacacagctg     5100

aagcttcgag gggctcgcat ctctccttca cgcgcccgcc gccctacctg aggccgccat     5160

ccacgccggt tgagtcgcgt tctgccgcct cccgcctgtg gtgcctcctg aactgcgtcc     5220

gccgtctagg taagtttaaa gctcaggtcg agaccgggcc tttgtccggc gctcccttgg     5280

agcctaccta gactcagccg gctctccacg ctttgcctga ccctgcttgc tcaactctac     5340

gtctttgttt cgttttctgt tctgcgccgt tacagatcca agctgtgacc ggcgcctact     5400

ctagagctag cgaattcgaa tttaaatcgg atccgcggcc gcgcccctct ccctcccccc     5460

cccctaacgt tactggccga agccgcttgg aataaggccg gtgtgcgttt gtctatatgt     5520

tattttccac catattgccg tcttttggca atgtgagggc ccggaaacct ggccctgtct     5580

tcttgacgag cattcctagg ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga     5640

atgtcgtgaa ggaagcagtt cctctggaag cttcttgaag acaaacaacg tctgtagcga     5700

ccctttgcag gcagcggaac cccccacctg gcgacaggtg cctctgcggc caaaagccac     5760

gtgtataaga tacacctgca aaggcggcac aaccccagtg ccacgttgtg agttggatag     5820

ttgtggaaag agtcaaatgg ctctcctcaa gcgtattcaa caaggggctg aaggatgccc     5880

agaaggtacc ccattgtatg ggatctgatc tggggcctcg gtgcacatgc tttacatgtg     5940

tttagtcgag gttaaaaaaa cgtctaggcc ccccgaacca cggggacgtg gttttccttt     6000

gaaaaacacg atgataatat ggccacaacc atggcgtccg gaatgattga acaagatgga     6060

ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa     6120

cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt     6180

ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaggacga ggcagcgcgg     6240

ctatcgtggc tggccgcgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa     6300

gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac     6360

cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt     6420

gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact     6480

cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg     6540

ccagccgaac tgttcgccag gctcaaggcg cgcatgcccg acggcgagga tctcgtcgtg     6600

acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc     6660

atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt     6720

gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc     6780

gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgagtc     6840

gacaatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt     6900

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc gttaactaaa     6960

cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa     7020

taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta     7080

tcatgtctgg aattgactca aatgatgtca attagtctat cagaagctca tctggtctcc     7140

cttccggggg acaagacatc cctgtttaat atttaaacag cagtgttccc aaactgggtt     7200

cttatatccc ttgctctggt caaccaggtt gcagggtttc ctgtcctcac aggaacgaag     7260

tccctaaaga aacagtggca gccaggttta gccccggaat tgactggatt ccttttttag     7320

ggcccattgg tatggctttt tccccgtatc cccccaggtg tctgcaggct caaagagcag     7380

cgagaagcgt tcagaggaaa gcgatcccgt gccaccttcc ccgtgcccgg gctgtccccg     7440

cacgctgccg gctcggggat gcggggggag cgccggaccg gagcggagcc ccgggcggct     7500

cgctgctgcc ccctagcggg ggagggacgt aattacatcc ctgggggctt tggggggggg     7560

ctgtccctga tatctataac aagaaaatat atatataata agttatcacg taagtagaac     7620

atgaaataac aatataatta tcgtatgagt taaatcttaa aagtcacgta aaagataatc     7680

atgcgtcatt ttgactcacg cggtcgttat agttcaaaat cagtgacact taccgcattg     7740

acaagcacgc ctcacgggag ctccaagcgg cgactgagat gtcctaaatg cacagcgacg     7800

gattcgcgct atttagaaag agagagcaat atttcaagaa tgcatgcgtc aattttacgc     7860

agactatctt tctaggg                                                    7877


<210>  17
<211>  8025
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgtgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaacaaa aactcaaaat ttcttctata aagtaacaaa tcctgtatta      240

gaggtcacgt gagtgttttg cgacattttg cgacaccatg tggtcacgct gggtatttaa      300

gcccgagtga gcacgcaggg tctccatttt gaagcgggag gtttgaacgc gcagccgcca      360

agccgaattc tgcagatatc cccgagtcct tcaatgctat cattcccttt gatattggac      420

catatgcata gtaccgagaa actagtgcga agtagtgatc aggtattgct gttagatatc      480

cccgagtcct tcaatgctat cattctcttt gatattggac catatgcata gtaccgagaa      540

actagtgcga agtagtgatc aggtattgct gttagatatc cccgagtcct tcaatgctat      600

cattcccttt gatattggac catatgcata gtaccgagaa actagtgcga agtagtgatc      660

aggtattgct gttagatatc cccgagtcct tcaatgctat cattctcttt gatattggac      720

catatgcata gtaccgagaa actagtgcga agtagtgatc aggtattgct gttagatatc      780

cccgagtcct tcaatgctat cattcccttt gatattggac catatgcata gtaccgagaa      840

actagtgcga agtagtgatc aggtattgct gttagatatc cccgagtcct tcaatgctat      900

catttccttt gatattggat catatgcata gtaccgagaa actagtgcga agtagtgatc      960

aggtattgct gttaaggatc catcacactg gcggccgctc gaggggagct cgcagggtct     1020

ccattttgaa gcgggaggtt tgaacgcgca gccgccatgc cggggtttta cgagattgtg     1080

attaaggtcc ccagcgacct tgacgagcat ctgcccggca tttctgacag ctttgtgaac     1140

tgggtggccg agaaggaatg ggagttgccg ccagattctg acatggatct gaatctgatt     1200

gagcaggcac ccctgaccgt ggccgagaag ctgcagcgcg actttctgac ggaatggcgc     1260

cgtgtgagta aggccccgga ggctcttttc tttgtgcaat ttgagaaggg agagagctac     1320

ttccacatgc acgtgctcgt ggaaaccacc ggggtgaaat ccatggtttt gggacgtttc     1380

ctgagtcaga ttcgcgaaaa actgattcag agaatttacc agcgggatcg agccgacttt     1440

gccaaactgg ttcgcggtca caaagaccag aaatggcgcc ggaggcggga acaaggtggt     1500

ggatgagtgc tacatcccca attacttgct ccccaaaacc cagcctgagc tccagtgggc     1560

gtggactaat atggaacagt atttaagcgc ctgtttgaat ctcacggagc gtaaacggtt     1620

ggtggcgcag catctgacgc acgtgtcgca gacgcaggag cagaacaaag agaatcagaa     1680

tcccaattct gatgcgccgg tgatcagatc aaaaacttca gccaggtaca tggagctggt     1740

cgggtggctc gtggacaagg ggattaccta ggagaagcag tggatccagg aggaccaggc     1800

ctcatacatc tccttcaatg cggcctccaa ctcgcggtcc caaatcaagg ctgccttgga     1860

caatgcggga aagattatga gcctgactaa aaccgccccc gactacctgg tgggccagca     1920

gcccgtggag gacatttcca gcaatcggat ttataaaatt ttggaactaa acgggtacga     1980

tccccaatat gcggcttccg tctttctggg atgggccacg aaaaagttcg gcaagaggaa     2040

caccatctgg ctgtttgggc ctgcaactac cgggaagacc aacatcgcgg aggccatagc     2100

ccacactgtg cccttctacg ggtgcgtaaa ctggaccaat gagaactttc ccttcaacga     2160

ctgtgtcgac aagatggtga tctggtggga ggaggggaag atgaccgcca aggtcgtgga     2220

gtcggccaaa gccattctcg gaggaagcaa ggtgcgcgtg gaccagaaat gcaagtcctc     2280

ggcccagata gacccgactc ccgtgatcgt cacctccaac accaacatgt gcgccgtgat     2340

tgacgggaac tcaacgacct tcgaacacca gcagccgttg caagaccgga tgttcaaatt     2400

tgaactcacc cgccgtctgg atcatgactt tgggaaggtc accaagcagg aagtcaaaga     2460

ctttttccgg tgggcaaagg atcacgtggt tgaggtggag catgaattct acgtcaaaaa     2520

gggtggagcc aagaaaagac ccgcccccag tgacgcagat ataagtgagc ccaaacgggt     2580

gcgcgagtca gttgcgcagc catcgacgtc agacgcggaa gcttcgatca actacgcaga     2640

caggtaccaa aacaaatgtt ctcgtcacgt gggcatgaat ctgatgctgt ttccctgcag     2700

acaatgcgag agaatgaatc agaattcaaa tatctgcttc actcacggac agaaagactg     2760

tttagagtgc tttcccgtgt cagaatctca acccgtttct gtcgtcaaaa aggcgtatca     2820

gaaactgtgc tacattcatc atatcatggg aaaggtgcca gacgcttgca ctgcctgcga     2880

tctggtcaat gtggatttgg atgactgcat ctttgaacaa taaatgattt aaatcaggta     2940

tggctgccga tggttatctt ccagattggc tcgaggacac tctctctgaa ggaataagac     3000

agtggtggaa gctcaaacct ggcccaccac caccaaagcc cgcagagcgg cataaggacg     3060

acagcagggg tcttgtgctt cctgggtaca agtacctcgg acccttcaac ggactcgaca     3120

agggagagcc ggtcaacgag gcagacgccg cggccctcga gcacgacaaa gcctacgacc     3180

ggcagctcga cagcggagac aacccgtacc tcaagtacaa ccacgccgac gcggagtttc     3240

aggagcgcct taaagaagat acgtcttttg ggggcaacct cggacgagca gtcttccagg     3300

cgaaaaagag ggttcttgaa cctctgggcc tggttgagga acctgttaag acggctccgg     3360

gaaaaaagag gccggtagag cactctcctg tggagccaga ctcctcctcg ggaaccggaa     3420

aggcgggcca gcagcctgca agaaaaagat tgaattttgg tcagactgga gacgcagact     3480

cagtacctga cccccagcct ctcggacagc caccagcagc cccctctggt ctgggaacta     3540

atacgatggc tacaggcagt ggcgcaccaa tggcagacaa taacgagggc gccgacggag     3600

tgggtaattc ctcgggaaat tggcattgcg attccacatg gatgggcgac agagtcatca     3660

ccaccagcac ccgaacctgg gccctgccca cctacaacaa ccacctctac aaacaaattt     3720

ccagccaatc aggagcctcg aacgacaatc actactttgg ctacagcacc ccttgggggt     3780

attttgactt caacagattc cactgccact tttcaccacg tgactggcaa agactcatca     3840

acaacaactg gggattccga cccaagagac tcaacttcaa gctctttaac attcaagtca     3900

aagaggtcac gcagaatgac ggtacgacga cgattgccaa taaccttacc agcacggttc     3960

aggtgtttac tgactcggag taccagctcc cgtacgtcct cggctcggcg catcaaggat     4020

gcctcccgcc gttcccagca gacgtcttca tggtgccaca gtatggatac ctcaccctga     4080

acaacgggag tcaggcagta ggacgctctt cattttactg cctggagtac tttccttctc     4140

agatgctgcg taccggaaac aactttacct tcagctacac ttttgaggac gttcctttcc     4200

acagcagcta cgctcacagc cagagtctgg accgtctcat gaatcctctc atcgaccagt     4260

acctgtatta cttgagcaga acaaacactc caagtggaac caccacgcag tcaaggcttc     4320

agttttctca ggccggagcg agtgacattc gggaccagtc taggaactgg cttcctggac     4380

cctgttaccg ccagcagcga gtatcaaaga catctgcgga taacaacaac agtgaatact     4440

cgtggactgg agctaccaag taccacctca atggcagaga ctctctggtg aatccgggcc     4500

cggccatggc aagccacaag gacgatgaag aaaagttttt tcctcagagc ggggttctca     4560

tctttgggaa gcaaggctca gagaaaacaa atgtggacat tgaaaaggtc atgattacag     4620

acgaagagga aatcaggaca accaatcccg tggctacgga gcagtatggt tctgtatcta     4680

ccaacctcca gagaggcaac agacaagcag ctaccgcaga tgtcaacaca caaggcgttc     4740

ttccaggcat ggtctggcag gacagagatg tgtaccttca ggggcccatc tgggcaaaga     4800

ttccacacac ggacggacat tttcacccct ctcccctcat gggtggattc ggacttaaac     4860

accctcctcc acagattctc atcaagaaca ccccggtacc tgcgaatcct tcgaccacct     4920

tcagtgcggc aaagtttgct tccttcatca cacagtactc cacgggacag gtcagcgtgg     4980

agatcgagtg ggagctgcag aaggaaaaca gcaaacgctg gaatcccgaa attcagtaca     5040

cttccaacta caacaagtct gttaatgtgg actttactgt ggacactaat ggcgtgtatt     5100

cagagcctcg ccccattggc accagatacc tgactcgtaa tctgtaattg cttgttaatc     5160

aataaaccgt ttaattcgtt tcagttgaac tttggtctct gcgtatttct ttcttatcta     5220

gtttccatgc tcctccacgg ccaaggatct gcgatcgctc cggtgcccgt cagtgggcag     5280

agcgcacatc gcccacagtc cccgagaagt tggggggagg ggtcggcaat tgaacgggtg     5340

cctagagaag gtggcgcggg gtaaactggg aaagtgatgt cgtgtactgg ctccgccttt     5400

ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt cgccgtgaac gttctttttc     5460

gcaacgggtt tgccgccaga acacagctga agcttcgagg ggctcgcatc tctccttcac     5520

gcgcccgccg ccctacctga ggccgccatc cacgccggtt gagtcgcgtt ctgccgcctc     5580

ccgcctgtgg tgcctcctga actgcgtccg ccgtctaggt aagtttaaag ctcaggtcga     5640

gaccgggcct ttgtccggcg ctcccttgga gcctacctag actcagccgg ctctccacgc     5700

tttgcctgac cctgcttgct caactctacg tctttgtttc gttttctgtt ctgcgccgtt     5760

acagatccaa gctgtgaccg gcgcctactc tagagctagc gaattcgaat ttaaatcgga     5820

tccgcggccg cgcccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga     5880

ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa     5940

tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc     6000

tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc     6060

ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg     6120

cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca     6180

accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag     6240

cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct     6300

ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc     6360

cccgaaccac ggggacgtgg ttttcctttg aaaaacacga tgataatatg gccacaacca     6420

tggcgtccgg aatgattgaa caagatggat tgcacgcagg ttctccggcc gcttgggtgg     6480

agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat gccgccgtgt     6540

tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg tccggtgccc     6600

tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccgcgacg ggcgttcctt     6660

gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta ttgggcgaag     6720

tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta tccatcatgg     6780

ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc gaccaccaag     6840

cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc gatcaggatg     6900

atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg ctcaaggcgc     6960

gcatgcccga cggcgaggat ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca     7020

tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt gtggcggacc     7080

gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc ggcgaatggg     7140

ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc atcgccttct     7200

atcgccttct tgacgagttc ttctgagtcg acaatcaacc tctggattac aaaatttgtg     7260

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     7320

taatgccttt gtatcatgcg ttaactaaac ttgtttattg cagcttataa tggttacaaa     7380

taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt     7440

ggtttgtcca aactcatcaa tgtatcttat catgtctgga attgactcaa atgatgtcaa     7500

ttagtctatc agaagctcat ctggtctccc ttccggggga caagacatcc ctgtttaata     7560

tttaaacagc agtgttccca aactgggttc ttatatccct tgctctggtc aaccaggttg     7620

cagggtttcc tgtcctcaca ggaacgaagt ccctaaagaa acagtggcag ccaggtttag     7680

ccccggaatt gactggattc cttttttagg gcccattggt attataacaa gaaaatatat     7740

atataataag ttatcacgta agtagaacat gaaataacaa tataattatc gtatgagtta     7800

aatcttaaaa gtcacgtaaa agataatcat gcgtcatttt gactcacgcg gtcgttatag     7860

ttcaaaatca gtgacactta ccgcattgac aagcacgcct cacgggagct ccaagcggcg     7920

actgagatgt cctaaatgca cagcgacgga ttcgcgctat ttagaaagag agagcaatat     7980

ttcaagaatg catgcgtcaa ttttacgcag actatctttc taggg                     8025


<210>  18
<211>  7387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  18
ccctagaaag ataatcatat tgtgacgtac gttaaagata atcatgtgta aaattgacgc       60

atgtgtttta tcggtctgta tatcgaggtt tatttattaa tttgaataga tattaagttt      120

tattatattt acacttacat actaataata aattcaacaa acaatttatt tatgtttatt      180

tatttattaa aaaaaacaaa aactcaaaat ttcttctata aagtaacaaa tcctgtatta      240

gaggtcacgt gagtgttttg cgacattttg cgacaccatg tggtcacgct gggtatttaa      300

gcccgagtga gcacgcaggg tctccatttt gaagcgagga tccatcacac tggcggccgc      360

tcgaggggag ctcgcagggt ctccattttg aagcgggagg tttgaacgcg cagccgccat      420

gccggggttt tacgagattg tgattaaggt ccccagcgac cttgacgagc atctgcccgg      480

catttctgac agctttgtga actgggtggc cgagaaggaa tgggagttgc cgccagattc      540

tgacatggat ctgaatctga ttgagcaggc acccctgacc gtggccgaga agctgcagcg      600

cgactttctg acggaatggc gccgtgtgag taaggccccg gaggctcttt tctttgtgca      660

atttgagaag ggagagagct acttccacat gcacgtgctc gtggaaacca ccggggtgaa      720

atccatggtt ttgggacgtt tcctgagtca gattcgcgaa aaactgattc agagaattta      780

ccagcgggat cgagccgact ttgccaaact ggttcgcggt cacaaagacc agaaatggcg      840

ccggaggcgg gaacaaggtg gtggatgagt gctacatccc caattacttg ctccccaaaa      900

cccagcctga gctccagtgg gcgtggacta atatggaaca gtatttaagc gcctgtttga      960

atctcacgga gcgtaaacgg ttggtggcgc agcatctgac gcacgtgtcg cagacgcagg     1020

agcagaacaa agagaatcag aatcccaatt ctgatgcgcc ggtgatcaga tcaaaaactt     1080

cagccaggta catggagctg gtcgggtggc tcgtggacaa ggggattacc taggagaagc     1140

agtggatcca ggaggaccag gcctcataca tctccttcaa tgcggcctcc aactcgcggt     1200

cccaaatcaa ggctgccttg gacaatgcgg gaaagattat gagcctgact aaaaccgccc     1260

ccgactacct ggtgggccag cagcccgtgg aggacatttc cagcaatcgg atttataaaa     1320

ttttggaact aaacgggtac gatccccaat atgcggcttc cgtctttctg ggatgggcca     1380

cgaaaaagtt cggcaagagg aacaccatct ggctgtttgg gcctgcaact accgggaaga     1440

ccaacatcgc ggaggccata gcccacactg tgcccttcta cgggtgcgta aactggacca     1500

atgagaactt tcccttcaac gactgtgtcg acaagatggt gatctggtgg gaggagggga     1560

agatgaccgc caaggtcgtg gagtcggcca aagccattct cggaggaagc aaggtgcgcg     1620

tggaccagaa atgcaagtcc tcggcccaga tagacccgac tcccgtgatc gtcacctcca     1680

acaccaacat gtgcgccgtg attgacggga actcaacgac cttcgaacac cagcagccgt     1740

tgcaagaccg gatgttcaaa tttgaactca cccgccgtct ggatcatgac tttgggaagg     1800

tcaccaagca ggaagtcaaa gactttttcc ggtgggcaaa ggatcacgtg gttgaggtgg     1860

agcatgaatt ctacgtcaaa aagggtggag ccaagaaaag acccgccccc agtgacgcag     1920

atataagtga gcccaaacgg gtgcgcgagt cagttgcgca gccatcgacg tcagacgcgg     1980

aagcttcgat caactacgca gacaggtacc aaaacaaatg ttctcgtcac gtgggcatga     2040

atctgatgct gtttccctgc agacaatgcg agagaatgaa tcagaattca aatatctgct     2100

tcactcacgg acagaaagac tgtttagagt gctttcccgt gtcagaatct caacccgttt     2160

ctgtcgtcaa aaaggcgtat cagaaactgt gctacattca tcatatcatg ggaaaggtgc     2220

cagacgcttg cactgcctgc gatctggtca atgtggattt ggatgactgc atctttgaac     2280

aataaatgat ttaaatcagg tatggctgcc gatggttatc ttccagattg gctcgaggac     2340

actctctctg aaggaataag acagtggtgg aagctcaaac ctggcccacc accaccaaag     2400

cccgcagagc ggcataagga cgacagcagg ggtcttgtgc ttcctgggta caagtacctc     2460

ggacccttca acggactcga caagggagag ccggtcaacg aggcagacgc cgcggccctc     2520

gagcacgaca aagcctacga ccggcagctc gacagcggag acaacccgta cctcaagtac     2580

aaccacgccg acgcggagtt tcaggagcgc cttaaagaag atacgtcttt tgggggcaac     2640

ctcggacgag cagtcttcca ggcgaaaaag agggttcttg aacctctggg cctggttgag     2700

gaacctgtta agacggctcc gggaaaaaag aggccggtag agcactctcc tgtggagcca     2760

gactcctcct cgggaaccgg aaaggcgggc cagcagcctg caagaaaaag attgaatttt     2820

ggtcagactg gagacgcaga ctcagtacct gacccccagc ctctcggaca gccaccagca     2880

gccccctctg gtctgggaac taatacgatg gctacaggca gtggcgcacc aatggcagac     2940

aataacgagg gcgccgacgg agtgggtaat tcctcgggaa attggcattg cgattccaca     3000

tggatgggcg acagagtcat caccaccagc acccgaacct gggccctgcc cacctacaac     3060

aaccacctct acaaacaaat ttccagccaa tcaggagcct cgaacgacaa tcactacttt     3120

ggctacagca ccccttgggg gtattttgac ttcaacagat tccactgcca cttttcacca     3180

cgtgactggc aaagactcat caacaacaac tggggattcc gacccaagag actcaacttc     3240

aagctcttta acattcaagt caaagaggtc acgcagaatg acggtacgac gacgattgcc     3300

aataacctta ccagcacggt tcaggtgttt actgactcgg agtaccagct cccgtacgtc     3360

ctcggctcgg cgcatcaagg atgcctcccg ccgttcccag cagacgtctt catggtgcca     3420

cagtatggat acctcaccct gaacaacggg agtcaggcag taggacgctc ttcattttac     3480

tgcctggagt actttccttc tcagatgctg cgtaccggaa acaactttac cttcagctac     3540

acttttgagg acgttccttt ccacagcagc tacgctcaca gccagagtct ggaccgtctc     3600

atgaatcctc tcatcgacca gtacctgtat tacttgagca gaacaaacac tccaagtgga     3660

accaccacgc agtcaaggct tcagttttct caggccggag cgagtgacat tcgggaccag     3720

tctaggaact ggcttcctgg accctgttac cgccagcagc gagtatcaaa gacatctgcg     3780

gataacaaca acagtgaata ctcgtggact ggagctacca agtaccacct caatggcaga     3840

gactctctgg tgaatccggg cccggccatg gcaagccaca aggacgatga agaaaagttt     3900

tttcctcaga gcggggttct catctttggg aagcaaggct cagagaaaac aaatgtggac     3960

attgaaaagg tcatgattac agacgaagag gaaatcagga caaccaatcc cgtggctacg     4020

gagcagtatg gttctgtatc taccaacctc cagagaggca acagacaagc agctaccgca     4080

gatgtcaaca cacaaggcgt tcttccaggc atggtctggc aggacagaga tgtgtacctt     4140

caggggccca tctgggcaaa gattccacac acggacggac attttcaccc ctctcccctc     4200

atgggtggat tcggacttaa acaccctcct ccacagattc tcatcaagaa caccccggta     4260

cctgcgaatc cttcgaccac cttcagtgcg gcaaagtttg cttccttcat cacacagtac     4320

tccacgggac aggtcagcgt ggagatcgag tgggagctgc agaaggaaaa cagcaaacgc     4380

tggaatcccg aaattcagta cacttccaac tacaacaagt ctgttaatgt ggactttact     4440

gtggacacta atggcgtgta ttcagagcct cgccccattg gcaccagata cctgactcgt     4500

aatctgtaat tgcttgttaa tcaataaacc gtttaattcg tttcagttga actttggtct     4560

ctgcgtattt ctttcttatc tagtttccat gctcctccac ggccaaggat ctgcgatcgc     4620

tccggtgccc gtcagtgggc agagcgcaca tcgcccacag tccccgagaa gttgggggga     4680

ggggtcggca attgaacggg tgcctagaga aggtggcgcg gggtaaactg ggaaagtgat     4740

gtcgtgtact ggctccgcct ttttcccgag ggtgggggag aaccgtatat aagtgcagta     4800

gtcgccgtga acgttctttt tcgcaacggg tttgccgcca gaacacagct gaagcttcga     4860

ggggctcgca tctctccttc acgcgcccgc cgccctacct gaggccgcca tccacgccgg     4920

ttgagtcgcg ttctgccgcc tcccgcctgt ggtgcctcct gaactgcgtc cgccgtctag     4980

gtaagtttaa agctcaggtc gagaccgggc ctttgtccgg cgctcccttg gagcctacct     5040

agactcagcc ggctctccac gctttgcctg accctgcttg ctcaactcta cgtctttgtt     5100

tcgttttctg ttctgcgccg ttacagatcc aagctgtgac cggcgcctac tctagagcta     5160

gcgaattcga atttaaatcg gatccgcggc cgcgcccctc tccctccccc ccccctaacg     5220

ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca     5280

ccatattgcc gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga     5340

gcattcctag gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga     5400

aggaagcagt tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca     5460

ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag     5520

atacacctgc aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa     5580

gagtcaaatg gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac     5640

cccattgtat gggatctgat ctggggcctc ggtgcacatg ctttacatgt gtttagtcga     5700

ggttaaaaaa acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac     5760

gatgataata tggccacaac catggcgtcc ggaatgattg aacaagatgg attgcacgca     5820

ggttctccgg ccgcttgggt ggagaggcta ttcggctatg actgggcaca acagacaatc     5880

ggctgctctg atgccgccgt gttccggctg tcagcgcagg ggcgcccggt tctttttgtc     5940

aagaccgacc tgtccggtgc cctgaatgaa ctgcaggacg aggcagcgcg gctatcgtgg     6000

ctggccgcga cgggcgttcc ttgcgcagct gtgctcgacg ttgtcactga agcgggaagg     6060

gactggctgc tattgggcga agtgccgggg caggatctcc tgtcatctca ccttgctcct     6120

gccgagaaag tatccatcat ggctgatgca atgcggcggc tgcatacgct tgatccggct     6180

acctgcccat tcgaccacca agcgaaacat cgcatcgagc gagcacgtac tcggatggaa     6240

gccggtcttg tcgatcagga tgatctggac gaagagcatc aggggctcgc gccagccgaa     6300

ctgttcgcca ggctcaaggc gcgcatgccc gacggcgagg atctcgtcgt gacccatggc     6360

gatgcctgct tgccgaatat catggtggaa aatggccgct tttctggatt catcgactgt     6420

ggccggctgg gtgtggcgga ccgctatcag gacatagcgt tggctacccg tgatattgct     6480

gaagagcttg gcggcgaatg ggctgaccgc ttcctcgtgc tttacggtat cgccgctccc     6540

gattcgcagc gcatcgcctt ctatcgcctt cttgacgagt tcttctgagt cgacaatcaa     6600

cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt     6660

acgctatgtg gatacgctgc tttaatgcct ttgtatcatg cgttaactaa acttgtttat     6720

tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt     6780

tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg     6840

gaattgactc aaatgatgtc aattagtcta tcagaagctc atctggtctc ccttccgggg     6900

gacaagacat ccctgtttaa tatttaaaca gcagtgttcc caaactgggt tcttatatcc     6960

cttgctctgg tcaaccaggt tgcagggttt cctgtcctca caggaacgaa gtccctaaag     7020

aaacagtggc agccaggttt agccccggaa ttgactggat tcctttttta gggcccattg     7080

gtattataac aagaaaatat atatataata agttatcacg taagtagaac atgaaataac     7140

aatataatta tcgtatgagt taaatcttaa aagtcacgta aaagataatc atgcgtcatt     7200

ttgactcacg cggtcgttat agttcaaaat cagtgacact taccgcattg acaagcacgc     7260

ctcacgggag ctccaagcgg cgactgagat gtcctaaatg cacagcgacg gattcgcgct     7320

atttagaaag agagagcaat atttcaagaa tgcatgcgtc aattttacgc agactatctt     7380

tctaggg                                                               7387


