                         SEQUENCE LISTING

<110>  The Board of Trustees of the University of Illinois
 
<120>  SHIGELLA MULTI-EPITOPE FUSION ANTIGEN PROTEINS AND METHODS OF USE

<130>  7950-103462-02

<150>  US 62/914,918
<151>  2019-10-14

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  1014
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A MEFA encoding nucleic acid

<400>  1
atgggcaata taacaactct gactaatagt atttccacct catcattcag cccaaacaat       60

accaacggtt catcaaccga aacagttaat tctgatataa aaacaacgac cagttctcat      120

cctgtaagtt cccttactat gctcaacgac acccttcata atatcagaac aacaaatcag      180

gcattaaaga aagatctctc acaaaaaacg ttgactaaaa catcgctaga agaaatagca      240

ttacattcat ctcagattag catggatgta aacaaatccg ctcaactatt ggatattctt      300

tccaagaaag aatatccaat taataaagac gcaagagaat tattacattc agcccaacta      360

gttggaaaaa ataatgaaga atctatgata tctcacagag aactgtggga taaaattgca      420

aagtcaatca ataatattaa tgaacagtat ctgaaagtat atgaacatgc cgttagttca      480

tatactcaat ctgctgaaca gctatcaacc cagcagaaaa gtcttgccgg ctggatctct      540

cccggaggta acgacggaaa ctccgtgaaa ttacaagtca agtctcttaa aagtgatagt      600

gatgggggga atggaggtga taaagataaa ccgctatatc cagcaaataa tactgttctg      660

cctgactatc atggacaaga ctctgttcgt gtagaattag gtggaacaga acgtaaaccg      720

aacgcttgta aagacgagta tgttgtcaat ataaacatga ccccaataga caatatgctt      780

ccggagtatc ggggagagga tggtgtcaga gtgggtgagg ttgtgctaga taatgcaaaa      840

tatcaggcat ggaatgccgg agagtataca aaatataatg atgacgatac caatcttcaa      900

accttagttc aaaaatacag taatgccaat agtatttttg ataatttagt aaaggttttg      960

agtagtacaa taagttcatg tacagataca gataaacttt ttctccattt ctga           1014


<210>  2
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A MEFA protein

<400>  2

Met Gly Asn Ile Thr Thr Leu Thr Asn Ser Ile Ser Thr Ser Ser Phe 
1               5                   10                  15      


Ser Pro Asn Asn Thr Asn Gly Ser Ser Thr Glu Thr Val Asn Ser Asp 
            20                  25                  30          


Ile Lys Thr Thr Thr Ser Ser His Pro Val Ser Ser Leu Thr Met Leu 
        35                  40                  45              


Asn Asp Thr Leu His Asn Ile Arg Thr Thr Asn Gln Ala Leu Lys Lys 
    50                  55                  60                  


Asp Leu Ser Gln Lys Thr Leu Thr Lys Thr Ser Leu Glu Glu Ile Ala 
65                  70                  75                  80  


Leu His Ser Ser Gln Ile Ser Met Asp Val Asn Lys Ser Ala Gln Leu 
                85                  90                  95      


Leu Asp Ile Leu Ser Lys Lys Glu Tyr Pro Ile Asn Lys Asp Ala Arg 
            100                 105                 110         


Glu Leu Leu His Ser Ala Gln Leu Val Gly Lys Asn Asn Glu Glu Ser 
        115                 120                 125             


Met Ile Ser His Arg Glu Leu Trp Asp Lys Ile Ala Lys Ser Ile Asn 
    130                 135                 140                 


Asn Ile Asn Glu Gln Tyr Leu Lys Val Tyr Glu His Ala Val Ser Ser 
145                 150                 155                 160 


Tyr Thr Gln Ser Ala Glu Gln Leu Ser Thr Gln Gln Lys Ser Leu Ala 
                165                 170                 175     


Gly Trp Ile Ser Pro Gly Gly Asn Asp Gly Asn Ser Val Lys Leu Gln 
            180                 185                 190         


Val Lys Ser Leu Lys Ser Asp Ser Asp Gly Gly Asn Gly Gly Asp Lys 
        195                 200                 205             


Asp Lys Pro Leu Tyr Pro Ala Asn Asn Thr Val Leu Pro Asp Tyr His 
    210                 215                 220                 


Gly Gln Asp Ser Val Arg Val Glu Leu Gly Gly Thr Glu Arg Lys Pro 
225                 230                 235                 240 


Asn Ala Cys Lys Asp Glu Tyr Val Val Asn Ile Asn Met Thr Pro Ile 
                245                 250                 255     


Asp Asn Met Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val Gly 
            260                 265                 270         


Glu Val Val Leu Asp Asn Ala Lys Tyr Gln Ala Trp Asn Ala Gly Glu 
        275                 280                 285             


Tyr Thr Lys Tyr Asn Asp Asp Asp Thr Asn Leu Gln Thr Leu Val Gln 
    290                 295                 300                 


Lys Tyr Ser Asn Ala Asn Ser Ile Phe Asp Asn Leu Val Lys Val Leu 
305                 310                 315                 320 


Ser Ser Thr Ile Ser Ser Cys Thr Asp Thr Asp Lys Leu Phe Leu His 
                325                 330                 335     


Phe 
    


<210>  3
<211>  1014
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A backbone encoding nucleic acid


<220>
<221>  misc_feature
<222>  (49)..(84)
<223>  'N' indicates any nucleic acid

<220>
<221>  misc_feature
<222>  (301)..(330)
<223>  'N' indicates any nucleic acid

<220>
<221>  misc_feature
<222>  (355)..(384)
<223>  'N' indicates any nucleic acid

<220>
<221>  misc_feature
<222>  (490)..(522)
<223>  'N' indicates any nucleic acid

<220>
<221>  misc_feature
<222>  (538)..(567)
<223>  'N' indicates any nucleic acid

<220>
<221>  misc_feature
<222>  (592)..(621)
<223>  'N' indicates any nucleic acid

<220>
<221>  misc_feature
<222>  (658)..(693)
<223>  'N' indicates any nucleic acid

<220>
<221>  misc_feature
<222>  (709)..(738)
<223>  'N' indicates any nucleic acid

<220>
<221>  misc_feature
<222>  (778)..(813)
<223>  'N' indicates any nucleic acid

<220>
<221>  misc_feature
<222>  (862)..(891)
<223>  'N' indicates any nucleic acid

<400>  3
atgggcaata taacaactct gactaatagt atttccacct catcattcnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnngttaat tctgatataa aaacaacgac cagttctcat      120

cctgtaagtt cccttactat gctcaacgac acccttcata atatcagaac aacaaatcag      180

gcattaaaga aagatctctc acaaaaaacg ttgactaaaa catcgctaga agaaatagca      240

ttacattcat ctcagattag catggatgta aacaaatccg ctcaactatt ggatattctt      300

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn gcaagagaat tattacattc agccnnnnnn      360

nnnnnnnnnn nnnnnnnnnn nnnnatgata tctcacagag aactgtggga taaaattgca      420

aagtcaatca ataatattaa tgaacagtat ctgaaagtat atgaacatgc cgttagttca      480

tatactcaan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nncttgccgg ctggatcnnn      540

nnnnnnnnnn nnnnnnnnnn nnnnnnnaaa ttacaagtca agtctcttaa annnnnnnnn      600

nnnnnnnnnn nnnnnnnnnn naaagataaa ccgctatatc cagcaaataa tactgttnnn      660

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngaattag gtggaacann nnnnnnnnnn      720

nnnnnnnnnn nnnnnnnnta tgttgtcaat ataaacatga ccccaataga caatatgnnn      780

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnggtgagg ttgtgctaga taatgcaaaa      840

tatcaggcat ggaatgccgg annnnnnnnn nnnnnnnnnn nnnnnnnnnn naatcttcaa      900

accttagttc aaaaatacag taatgccaat agtatttttg ataatttagt aaaggttttg      960

agtagtacaa taagttcatg tacagataca gataaacttt ttctccattt ctga           1014


<210>  4
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A backbone protein


<220>
<221>  MISC_FEATURE
<222>  (17)..(28)
<223>  'Xaa' indicates any amino acid

<220>
<221>  MISC_FEATURE
<222>  (101)..(110)
<223>  'Xaa' indicates any amino acid

<220>
<221>  MISC_FEATURE
<222>  (119)..(128)
<223>  'Xaa' indicates any amino acid

<220>
<221>  MISC_FEATURE
<222>  (164)..(174)
<223>  'Xaa' indicates any amino acid

<220>
<221>  MISC_FEATURE
<222>  (180)..(189)
<223>  'Xaa' indicates any amino acid

<220>
<221>  MISC_FEATURE
<222>  (198)..(207)
<223>  'Xaa' indicates any amino acid

<220>
<221>  MISC_FEATURE
<222>  (220)..(231)
<223>  'Xaa' indicates any amino acid

<220>
<221>  MISC_FEATURE
<222>  (237)..(246)
<223>  'Xaa' indicates any amino acid

<220>
<221>  MISC_FEATURE
<222>  (260)..(271)
<223>  'Xaa' indicates any amino acid

<220>
<221>  MISC_FEATURE
<222>  (288)..(297)
<223>  'Xaa' indicates any amino acid

<400>  4

Met Gly Asn Ile Thr Thr Leu Thr Asn Ser Ile Ser Thr Ser Ser Phe 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Asn Ser Asp 
            20                  25                  30          


Ile Lys Thr Thr Thr Ser Ser His Pro Val Ser Ser Leu Thr Met Leu 
        35                  40                  45              


Asn Asp Thr Leu His Asn Ile Arg Thr Thr Asn Gln Ala Leu Lys Lys 
    50                  55                  60                  


Asp Leu Ser Gln Lys Thr Leu Thr Lys Thr Ser Leu Glu Glu Ile Ala 
65                  70                  75                  80  


Leu His Ser Ser Gln Ile Ser Met Asp Val Asn Lys Ser Ala Gln Leu 
                85                  90                  95      


Leu Asp Ile Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Arg 
            100                 105                 110         


Glu Leu Leu His Ser Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Met Ile Ser His Arg Glu Leu Trp Asp Lys Ile Ala Lys Ser Ile Asn 
    130                 135                 140                 


Asn Ile Asn Glu Gln Tyr Leu Lys Val Tyr Glu His Ala Val Ser Ser 
145                 150                 155                 160 


Tyr Thr Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Ala 
                165                 170                 175     


Gly Trp Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Leu Gln 
            180                 185                 190         


Val Lys Ser Leu Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys 
        195                 200                 205             


Asp Lys Pro Leu Tyr Pro Ala Asn Asn Thr Val Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Leu Gly Gly Thr Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Tyr Val Val Asn Ile Asn Met Thr Pro Ile 
                245                 250                 255     


Asp Asn Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
            260                 265                 270         


Glu Val Val Leu Asp Asn Ala Lys Tyr Gln Ala Trp Asn Ala Gly Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Leu Gln Thr Leu Val Gln 
    290                 295                 300                 


Lys Tyr Ser Asn Ala Asn Ser Ile Phe Asp Asn Leu Val Lys Val Leu 
305                 310                 315                 320 


Ser Ser Thr Ile Ser Ser Cys Thr Asp Thr Asp Lys Leu Phe Leu His 
                325                 330                 335     


Phe 
    


<210>  5
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  An IpaD epitope encoding nucleic acid

<400>  5
agcccaaaca ataccaacgg ttcatcaacc gaaaca                                 36


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  An IpaD epitope

<400>  6

Ser Pro Asn Asn Thr Asn Gly Ser Ser Thr Glu Thr 
1               5                   10          


<210>  7
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  An IpaD epitope encoding nucleic acid

<400>  7
tccaagaaag aatatccaat taataaagac                                        30


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  An IpaD epitope

<400>  8

Ser Lys Lys Glu Tyr Pro Ile Asn Lys Asp 
1               5                   10  


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  An IpaB epitope encoding nucleic acid

<400>  9
caactagttg gaaaaaataa tgaagaatct                                        30


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  An IpaB epitope

<400>  10

Gln Leu Val Gly Lys Asn Asn Glu Glu Ser 
1               5                   10  


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  An IpaB epitope encoding nucleic acid

<400>  11
tctgctgaac agctatcaac ccagcagaaa agt                                    33


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  An IpaB epitope

<400>  12

Ser Ala Glu Gln Leu Ser Thr Gln Gln Lys Ser 
1               5                   10      


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  An IpaD epitope encoding nucleic acid

<400>  13
tctcccggag gtaacgacgg aaactccgtg                                        30


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  An IpaD epitope

<400>  14

Ser Pro Gly Gly Asn Asp Gly Asn Ser Val 
1               5                   10  


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A VirG epitope encoding nucleic acid

<400>  15
agtgatagtg atggggggaa tggaggtgat                                        30


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A VirG epitope

<400>  16

Ser Asp Ser Asp Gly Gly Asn Gly Gly Asp 
1               5                   10  


<210>  17
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A StxA epitope encoding nucleic acid

<400>  17
ctgcctgact atcatggaca agactctgtt cgtgta                                 36


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A StxA epitope

<400>  18

Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val 
1               5                   10          


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A GuaB epitope encoding nucleic acid

<400>  19
gaacgtaaac cgaacgcttg taaagacgag                                        30


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A GuaB epitope

<400>  20

Glu Arg Lys Pro Asn Ala Cys Lys Asp Glu 
1               5                   10  


<210>  21
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A Stx2 epitope encoding nucleic acid

<400>  21
cttccggagt atcggggaga ggatggtgtc agagtg                                 36


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Stx2 epitope

<400>  22

Leu Pro Glu Tyr Arg Gly Glu Asp Gly Val Arg Val 
1               5                   10          


<210>  23
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A StxB epitope encoding nucleic acid

<400>  23
gagtatacaa aatataatga tgacgatacc                                        30


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A StxB epitope

<400>  24

Glu Tyr Thr Lys Tyr Asn Asp Asp Asp Thr 
1               5                   10  


<210>  25
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CFA/I/II/IV MEFA encoding nucleic acid

<400>  25
atggaaatgg ctagcgcagt agaggatttt ttcattgttc cagtttctgg agatcctgca       60

attgatcttt tgcaagctga tggcaatgct ctgccatcag ctgtaaagtt agcttattct      120

cccgcatcaa aaactaatac tttggtgggt gttttgactc ttgtacatac aaacgatgca      180

actaaaaaaa atgtactagt taagcttgta acaccacagc ttacagatgt tctgaatcca      240

accctgcaaa ttcctgtttc tgtgcaggta acggtctacc ctgtttctac aacagccaaa      300

gaatttgaag ctgctgcttt gggatattct gcatccggtg taaatggctt ggtgtcaatt      360

gtgcttactg taattagcgc tgcacctaaa actgccggta ccgccccaac tgcaggaaac      420

tattcaggag tagtatctct tgtaatgact ttgggagcct gataacggcc gcactcgagc      480


<210>  26
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFA/I/II/IV MEFA protein

<400>  26

Met Glu Met Ala Ser Ala Val Glu Asp Phe Phe Ile Val Pro Val Ser 
1               5                   10                  15      


Gly Asp Pro Ala Ile Asp Leu Leu Gln Ala Asp Gly Asn Ala Leu Pro 
            20                  25                  30          


Ser Ala Val Lys Leu Ala Tyr Ser Pro Ala Ser Lys Thr Asn Thr Leu 
        35                  40                  45              


Val Gly Val Leu Thr Leu Val His Thr Asn Asp Ala Thr Lys Lys Asn 
    50                  55                  60                  


Val Leu Val Lys Leu Val Thr Pro Gln Leu Thr Asp Val Leu Asn Pro 
65                  70                  75                  80  


Thr Leu Gln Ile Pro Val Ser Val Gln Val Thr Val Tyr Pro Val Ser 
                85                  90                  95      


Thr Thr Ala Lys Glu Phe Glu Ala Ala Ala Leu Gly Tyr Ser Ala Ser 
            100                 105                 110         


Gly Val Asn Gly Leu Val Ser Ile Val Leu Thr Val Ile Ser Ala Ala 
        115                 120                 125             


Pro Lys Thr Ala Gly Thr Ala Pro Thr Ala Gly Asn Tyr Ser Gly Val 
    130                 135                 140                 


Val Ser Leu Val Met Thr Leu Gly Ala 
145                 150             


<210>  27
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Toxoid fusion 3xSTaN12S-mnLTR192G/L211A encoding nucleic acid

<400>  27
atggaaatgg ctagcatgaa tagtagcaat tactgctgtg aattgtgttg tagccctgct       60

tgtaccgggt gctatgggcc ggggcccaat ggcgacaaat tataccgtgc tgactctaga      120

cccccagatg aaataaaacg ttccggaggt cttatgccca gagggcataa tgagtacttc      180

gatagaggaa ctcaaatgaa tattaatctt tatgatcacg cgagaggaac acaaaccggc      240

tttgtcagat atgatgacgg atatgtttcc acttctctta gtttgagaag tgctcactta      300

gcaggacagt ctatattatc aggatattcc acttactata tatatgttat agcgacagca      360

ccaaatatgt ttaatgttaa tgatgtatta ggcgtataca gccctcaccc atatgaacag      420

gaggtttctg cgttaggtgg aataccatat tctcagatat atggatggta tcgtgttaat      480

tttggtgtga ttgatgaacg attacatcgt aacagggaat atagagaccg gtattacaga      540

aatctgaata tagctccggc agaggatggt tacagattag caggtttccc accggatcac      600

caagcttgga gagaagaacc ctggattcat catgcaccac aaggttgtgg aaattcatca      660

ggagggccgg tcgacatgaa tagtagcaat tactgctgtg aattgtgttg tagccctgct      720

tgtaccgggt gctatacaat tacaggtgat acttgtaatg aggagaccca gaatctgagc      780

acaatatatg ccaggaaata tcaatcaaaa gttaagaggc agatattttc agactatcag      840

tcagaggttg acatatataa cagaattcgg aatgaattag ggccggggcc cgctccccag      900

tctattacag aactatgttc ggaatatcgc aacacacaaa tatatacgat aaatgacaag      960

atactatcat atacggaatc gatggcaggc aaaagagaaa tggttatcat tacatttaag     1020

agcggcgcaa catttcaggt cgaagtcccg ggcagtcaac atatagactc ccaaaaaaaa     1080

gccattgaaa ggatgaagga cacattaaga atcacatatc tgaccgagac caaaattgat     1140

aaattatgtg tatggaataa taaaaccccc aattcaattg cggcaatcag tgatccccgg     1200

gtaccgagct cgatgaatag tagcaattac tgctgtgaat tgtgttgtag ccctgcttgt     1260

accgggtgct attaataa                                                   1278


<210>  28
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Toxoid fusion 3xSTaN12S-mnLTR192G/L211A protein

<400>  28

Met Glu Met Ala Ser Met Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys 
1               5                   10                  15      


Cys Ser Pro Ala Cys Thr Gly Cys Tyr Gly Pro Gly Pro Asn Gly Asp 
            20                  25                  30          


Lys Leu Tyr Arg Ala Asp Ser Arg Pro Pro Asp Glu Ile Lys Arg Ser 
        35                  40                  45              


Gly Gly Leu Met Pro Arg Gly His Asn Glu Tyr Phe Asp Arg Gly Thr 
    50                  55                  60                  


Gln Met Asn Ile Asn Leu Tyr Asp His Ala Arg Gly Thr Gln Thr Gly 
65                  70                  75                  80  


Phe Val Arg Tyr Asp Asp Gly Tyr Val Ser Thr Ser Leu Ser Leu Arg 
                85                  90                  95      


Ser Ala His Leu Ala Gly Gln Ser Ile Leu Ser Gly Tyr Ser Thr Tyr 
            100                 105                 110         


Tyr Ile Tyr Val Ile Ala Thr Ala Pro Asn Met Phe Asn Val Asn Asp 
        115                 120                 125             


Val Leu Gly Val Tyr Ser Pro His Pro Tyr Glu Gln Glu Val Ser Ala 
    130                 135                 140                 


Leu Gly Gly Ile Pro Tyr Ser Gln Ile Tyr Gly Trp Tyr Arg Val Asn 
145                 150                 155                 160 


Phe Gly Val Ile Asp Glu Arg Leu His Arg Asn Arg Glu Tyr Arg Asp 
                165                 170                 175     


Arg Tyr Tyr Arg Asn Leu Asn Ile Ala Pro Ala Glu Asp Gly Tyr Arg 
            180                 185                 190         


Leu Ala Gly Phe Pro Pro Asp His Gln Ala Trp Arg Glu Glu Pro Trp 
        195                 200                 205             


Ile His His Ala Pro Gln Gly Cys Gly Asn Ser Ser Gly Gly Pro Val 
    210                 215                 220                 


Asp Met Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys Ser Pro Ala 
225                 230                 235                 240 


Cys Thr Gly Cys Tyr Thr Ile Thr Gly Asp Thr Cys Asn Glu Glu Thr 
                245                 250                 255     


Gln Asn Leu Ser Thr Ile Tyr Ala Arg Lys Tyr Gln Ser Lys Val Lys 
            260                 265                 270         


Arg Gln Ile Phe Ser Asp Tyr Gln Ser Glu Val Asp Ile Tyr Asn Arg 
        275                 280                 285             


Ile Arg Asn Glu Leu Gly Pro Gly Pro Ala Pro Gln Ser Ile Thr Glu 
    290                 295                 300                 


Leu Cys Ser Glu Tyr Arg Asn Thr Gln Ile Tyr Thr Ile Asn Asp Lys 
305                 310                 315                 320 


Ile Leu Ser Tyr Thr Glu Ser Met Ala Gly Lys Arg Glu Met Val Ile 
                325                 330                 335     


Ile Thr Phe Lys Ser Gly Ala Thr Phe Gln Val Glu Val Pro Gly Ser 
            340                 345                 350         


Gln His Ile Asp Ser Gln Lys Lys Ala Ile Glu Arg Met Lys Asp Thr 
        355                 360                 365             


Leu Arg Ile Thr Tyr Leu Thr Glu Thr Lys Ile Asp Lys Leu Cys Val 
    370                 375                 380                 


Trp Asn Asn Lys Thr Pro Asn Ser Ile Ala Ala Ile Ser Asp Pro Arg 
385                 390                 395                 400 


Val Pro Ser Ser Met Asn Ser Ser Asn Tyr Cys Cys Glu Leu Cys Cys 
                405                 410                 415     


Ser Pro Ala Cys Thr Gly Cys Tyr 
            420                 


