                         SEQUENCE LISTING

<110>  Regents of the University of Minnesota
       Felices, Martin
       Miller, Jeffrey S.
 
<120>  CLEC12A ANTIBODY FRAGMENT SEQUENCES AND METHODS

<130>  0110-000633WO01

<150>  62/916,340
<151>  2019-10-17

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 1

<400>  1

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Arg Phe Ser Asn Asp 
            20                  25                  30          


Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Val Thr Gln Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Glu Pro Leu Asp Ala Glu Asp Leu Trp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 3

<400>  2

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Arg Val Ser Ala Gln 
            20                  25                  30          


Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Lys Lys Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Asp His Gly Glu Glu His Lys Glu Leu Tyr Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 9

<400>  3

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Asp Gln 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Leu Ala Thr Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Glu Val Glu Lys Ser Ser Gln Ser Met Pro Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 10

<400>  4

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Asn Val Thr Ala Asp 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asp Gly Gly Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Phe Thr Ser His Glu Ala Glu Val His Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  5
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 11

<400>  5

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Leu Ser Asn Asp 
            20                  25                  30          


Ile Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Val Asp Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Asn Glu Asp Asp Val Ser Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  6
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 17

<400>  6

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ile Ala Gln 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ala Thr Asn Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Ser Ser Trp Glu Asn Asp Leu Trp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  7
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 23

<400>  7

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Leu Thr Asp Glu 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ala Thr Arg Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Leu Arg Asp Gln Leu Tyr Gly Asn Glu Gln Leu Ala Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 29

<400>  8

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Asn Val Ile Tyr Glu 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Val Pro Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Val Gly Gln Asp Trp Phe Gln Ala Glu Pro Ser Glu Met 
            100                 105                 110         


Tyr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  9
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 33

<400>  9

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Met Phe Ser Tyr Asp 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gln Asn Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Leu Tyr Asp Arg Met Val Gly Lys Glu Glu Gln Leu Ala Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 40

<400>  10

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Ile Asn Pro Glu 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Glu Ala Gln Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Thr Ala His Gln Glu Glu Pro Val Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 56

<400>  11

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Thr Asp His 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Thr Val Gly Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Pro Leu Pro His Gln Glu Val Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  12
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 60

<400>  12

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Met Phe Ser Ala Asp 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Trp Ile Pro Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gln Leu Asn Glu Arg Ile Ala Ser Ile Thr Lys Asn Met His 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  13
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 86

<400>  13

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Met Leu Ser Ala Gln 
            20                  25                  30          


Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Ser Asp Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Leu Trp Gly Glu Asp Val Ile Met Gln Asp Ser Ser Val Gly 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  14
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  anti-CLEC12A clone consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X= any amino acid or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X= any amino acid or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (52)..(54)
<223>  X= any amino acid or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (98)..(110)
<223>  X= any amino acid or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  X= any amino acid or no amino acid

<400>  14

Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Xaa Val Ser Xaa Asp 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Xaa Xaa Xaa Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  15
<211>  533
<212>  PRT
<213>  Artificial

<220>
<223>  CLEC12A TriKE amino acid sequence

<400>  15

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser 
        35                  40                  45              


Ser Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Ala Val Ala Ser Ile Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Ala Asn Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
                165                 170                 175     


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
            180                 185                 190         


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
        195                 200                 205             


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
    210                 215                 220                 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
225                 230                 235                 240 


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
                245                 250                 255     


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
            260                 265                 270         


Ile Asn Thr Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
        275                 280                 285             


Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
    290                 295                 300                 


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Val Val Ser Gly 
305                 310                 315                 320 


Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Pro 
            340                 345                 350         


Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys 
        355                 360                 365             


Ser Arg Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
    370                 375                 380                 


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Thr Gly Gly Phe Phe Asp 
385                 390                 395                 400 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Glu Leu Thr 
            420                 425                 430         


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        435                 440                 445             


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
    450                 455                 460                 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
465                 470                 475                 480 


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                485                 490                 495     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            500                 505                 510         


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro Thr Phe Gly Pro Gly 
        515                 520                 525             


Thr Lys Val Glu Ile 
    530             


<210>  16
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 1

<400>  16
caggtgcagc tgtaggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggaga taggtttagc aatgacgtta tggcctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcagcc attgttaccc aagacggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gggagagcct      300

cttgatgccg aggacttgtg gtattggggt cagggaaccc tggtcaccgt ctcgagc         357


<210>  17
<211>  330
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 3

<400>  17
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

gcttagttta tgagctgggt ccgccaggct ccagggaagg gtctagagtg ggtatcaagc      120

atttataaga aaaacggtag cacatactac gcagactccg tgaagggccg gttcaccatc      180

tcccgtgaca attccaagaa cacgctgtat ctgcaaatga acagcctgcg tgccgaggac      240

accgcggtat attattgcgc gattgatcat ggggaggagc acaaggagct gtactcttgg      300

ggtcagggaa ccctggtcac cgtctcgagc                                       330


<210>  18
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 9

<400>  18
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggata tagcattacc gattaggata tgagctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcaggc attctggcca caagcggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gggagaggtt      300

gagaagagtt cccagtcgat gccgttttgg ggtcagggaa ccctggtcac cgtctcgagc      360


<210>  19
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 10

<400>  19
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggagt taacgttacc gctgacgata tgagctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcaacc attgatggcg gtgacggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gactgctttt      300

acgtcgcatg aggcggaggt ccactcttgg ggtcagggaa ccctggtcac cgtctcgagc      360


<210>  20
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 11

<400>  20
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggata taggcttagc aatgacatta tggcctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcagcc attgtggaca cagacggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gagagatcct      300

tataatgagg acgacgtcag ctattggggt cagggaaccc tggtcaccgt ctcgagc         357


<210>  21
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 17

<400>  21
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggatt taggtttatc gcttaggata tgagctgggt ccgccaggct      120

acagggaagg gtctagagtg ggtatcaacc attgctacga atgacggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gactgattcg      300

tcttgggaga acgacttgtg gtattggggt cagggaaccc tggtcaccgt ctcgagc         357


<210>  22
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 23

<400>  22
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggatt taggcttacc gatgaggata tgagctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcaacc attgctacca gagacggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gggacttagg      300

gatcagttgt atgggaacga gtagttggcc ttttggggtc agggaaccct ggtcaccgtc      360

tcgagc                                                                 366


<210>  23
<211>  375
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 29

<400>  23
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggata taacgttatc tatgaggata tgggctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcaggc attgatgtcc ctagcggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc ggctgttgtt      300

ggtcaggatt ggttttaggc tgagccctcg gagatgtact attggggtca gggaaccctg      360

gtcaccgtct cgagc                                                       375


<210>  24
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 33

<400>  24
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggaga tatgtttagc tatgacgata tgggctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcaggc atttagaaca ctgacggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gactctgtat      300

gataggatgg ttgggaagga ggagcagttg gcctcttggg gtcagggaac cctggtcacc      360

gtctcgagc                                                              369


<210>  25
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 40

<400>  25
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggaga taccattaac cctgaggata tgggctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcagcc attgaggcgc aaagcggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gagattgact      300

gctcattagg aggagccggt cgcgtattgg ggtcagggaa ccctggtcac cgtctcgagc      360


<210>  26
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 56

<400>  26
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggatt tacggttacc gatcacgata tgggctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcaagc attactgtgg gaaacggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gacagagcct      300

ttgccgcact aggaggtcac gtattggggt cagggaaccc tggtcaccgt ctcgagc         357


<210>  27
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 60

<400>  27
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggatt tacggttacc gatcacgata tgggctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcaagc attactgtgg gaaacggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gacagagcct      300

ttgccgcact aggaggtcac gtattggggt cagggaaccc tggtcaccgt ctcgagc         357


<210>  28
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  anti-CLEC12A clone 86

<400>  28
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       60

tcctgtgcag cctccggaga tatgcttagc gcttaggata tgggctgggt ccgccaggct      120

ccagggaagg gtctagagtg ggtatcaggc attgatagcg atgacggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc ggcattgtgg      300

ggggaggatg tgattatgta ggactcgtcg gtggggtctt ggggtcaggg aaccctggtc      360

accgtctcga gc                                                          372


<210>  29
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X= N, A, D, Y, or P

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= D, E, H, Q, or deletion

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= V, F, I, or D

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X= A, S, or G

<400>  29

Xaa Xaa Xaa Met Xaa 
1               5   


<210>  30
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X= A,S,T, or G

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= V,Y,L,D,A,E,T,W, Q, or deletion

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X= T,K,A,G,D,V,N,I, or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X= Q,K,T,G,N,R,P, or D

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= D,N, or S

<400>  30

Xaa Ile Xaa Xaa Xaa Xaa Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly Arg Phe Thr 
            20  


<210>  31
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDR3


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X= P,E,S,Q,R,or H

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X= any amino acid or deletion

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X= L,M,or V

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X= W,Y,P,H,S,A,T, or G

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X= Y,S, or F

<400>  31

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  32
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Signal peptide

<400>  32

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  33
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Histidine tag, including spacer

<400>  33

Val Asp Glu His His His His His His His His His His 
1               5                   10              


<210>  34
<211>  298
<212>  PRT
<213>  Artificial

<220>
<223>  CD16-huCAM Clone 33 bi-specific compound

<400>  34

Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala Tyr 
1               5                   10                  15      


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser 
        35                  40                  45              


Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Ala 
    50                  55                  60                  


Val Ala Ser Ile Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Ala Asn Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Ser Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
                165                 170                 175     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Met Phe 
            180                 185                 190         


Ser Tyr Asp Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        195                 200                 205             


Glu Trp Val Ser Gly Ile Gln Asn Thr Asp Gly Ser Thr Tyr Tyr Ala 
    210                 215                 220                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
225                 230                 235                 240 


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Ala Thr Leu Tyr Asp Arg Met Val Gly Lys Glu Glu Gln 
            260                 265                 270         


Leu Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser 
        275                 280                 285             


His His His His His His His His His His 
    290                 295             


<210>  35
<211>  430
<212>  PRT
<213>  Artificial

<220>
<223>  CD16-huCAM Clone 33 tri-specific compound

<400>  35

Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala Tyr 
1               5                   10                  15      


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            20                  25                  30          


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Ser 
        35                  40                  45              


Tyr Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Gly Leu Glu Ala 
    50                  55                  60                  


Val Ala Ser Ile Thr Trp Ser Gly Arg Asp Thr Phe Tyr Ala Asp Ser 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Ala Asn Pro Trp Pro Val Ala Ala Pro Arg Ser Gly Thr Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
                165                 170                 175     


Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
            180                 185                 190         


His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
        195                 200                 205             


Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
    210                 215                 220                 


Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
                245                 250                 255     


Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
            260                 265                 270         


Asn Thr Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
        275                 280                 285             


Gly Ser Thr Lys Gly Gly Ser Gln Val Gln Leu Leu Glu Ser Gly Gly 
    290                 295                 300                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
305                 310                 315                 320 


Gly Asp Met Phe Ser Tyr Asp Asp Met Gly Trp Val Arg Gln Ala Pro 
                325                 330                 335     


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Gln Asn Thr Asp Gly Ser 
            340                 345                 350         


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        355                 360                 365             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    370                 375                 380                 


Asp Thr Ala Val Tyr Tyr Cys Ala Thr Leu Tyr Asp Arg Met Val Gly 
385                 390                 395                 400 


Lys Glu Glu Gln Leu Ala Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
                405                 410                 415     


Ser Ser Gly Ser His His His His His His His His His His 
            420                 425                 430 


<210>  36
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker

<400>  36

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


