                         SEQUENCE LISTING

<110>  Aro Biotherapeutics Company
 
<120>  EPCAM BINDING FIBRONECTIN TYPE III DOMAINS

<130>  145965.02202

<150>  62/914,654
<151>  2019-10-14

<160>  71    

<170>  PatentIn version 3.5

<210>  1
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  1

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  2
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  n=7-12

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X1, X2, X3, X4, X5, X6, X7 is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X8, X9, X10, X11 and X12 are any amino acid or deleted

<400>  2

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Xaa Pro Leu Ser Ala Glu 
65                  70                  75                  80  


Phe Thr Thr 
            


<210>  3
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  X1 is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe,
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X2 is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe,
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  X3 Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe, 
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X4 is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe,
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X5 is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe,
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X6 is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe,
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  X  is Asp, Glu or Thr

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe, 
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  X is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe, 
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (77)..(77)
<223>  X is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe, 
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  X is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe, 
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  X13 is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, 
       Phe, Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  X is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe, 
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  X is Ala, Arg, Asn, Asp, Glu, Gln, Gly, His, Ile, Leu, Lys, Phe, 
       Pro, Ser, Thr, Trp, Tyr or Val

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Xaa Xaa Xaa Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Xaa Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  4
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  5
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (22)..(28)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (29)..(31)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr or deleted

<220>
<221>  MISC_FEATURE
<222>  (78)..(84)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (85)..(87)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr or deleted

<400>  5

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr 
    


<210>  6
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (75)..(82)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (83)..(87)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr or deleted

<400>  6

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  7
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr, Cys or Met

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr, Cys or Met

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr, Cys or Met

<220>
<221>  MISC_FEATURE
<222>  (38)..(41)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr, Cys or Met

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr, Cys or Met

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr, Cys or Met

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr, Cys or Met

<220>
<221>  MISC_FEATURE
<222>  (78)..(79)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr, Cys or Met

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Trp, Tyr, Cys or Met

<400>  7

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 
            20                  25                  30          


Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  8
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (38)..(41)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (48)..(48)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (68)..(68)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (78)..(79)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  X is Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Asn, Pro, Gln, 
       Arg, Ser, Thr, Val, Tyr or Trp.

<400>  8

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Xaa 
            20                  25                  30          


Ile Xaa Tyr Xaa Glu Xaa Xaa Xaa Xaa Gly Glu Ala Ile Xaa Leu Xaa 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Xaa Val Xaa Ile Xaa Gly Val Lys Gly Gly Xaa Xaa Ser 
65                  70                  75                  80  


Xaa Pro Leu Xaa Ala Xaa Phe Thr Thr 
                85                  


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9
gtgacacggc ggttagaac                                                    19


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10
gcctttggga agcttctaag                                                   20


<210>  11
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  11
cggcggttag aacgcggcta caattaatac                                        30


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  12
catgattacg ccaagctcag aa                                                22


<210>  13
<211>  385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (198)..(224)
<223>  N is any base

<400>  13
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctgaagtt accgaagact      180

ctctgcgtct gtcttggnnn nnnnnnnnnn nnnnnnnnnn nnnnttygac tctttcctga      240

tccagtacca ggaatctgaa aaagttggtg aagcgatcaa cctgaccgtt ccgggttctg      300

aacgttctta cgacctgacc ggtctgaaac cgggtaccga atacaccgtt tctatctacg      360

gtgttcttag aagcttccca aaggc                                            385


<210>  14
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (198)..(221)
<223>  N is any base

<400>  14
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctgaagtt accgaagact      180

ctctgcgtct gtcttggnnn nnnnnnnnnn nnnnnnnnnn nttygactct ttcctgatcc      240

agtaccagga atctgaaaaa gttggtgaag cgatcaacct gaccgttccg ggttctgaac      300

gttcttacga cctgaccggt ctgaaaccgg gtaccgaata caccgtttct atctacggtg      360

ttcttagaag cttcccaaag gc                                               382


<210>  15
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (198)..(218)
<223>  N is any base

<400>  15
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctgaagtt accgaagact      180

ctctgcgtct gtcttggnnn nnnnnnnnnn nnnnnnnntt ygactctttc ctgatccagt      240

accaggaatc tgaaaaagtt ggtgaagcga tcaacctgac cgttccgggt tctgaacgtt      300

cttacgacct gaccggtctg aaaccgggta ccgaatacac cgtttctatc tacggtgttc      360

ttagaagctt cccaaaggc                                                   379


<210>  16
<211>  376
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (198)..(215)
<223>  N is any base

<400>  16
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctgaagtt accgaagact      180

ctctgcgtct gtcttggnnn nnnnnnnnnn nnnnnttyga ctctttcctg atccagtacc      240

aggaatctga aaaagttggt gaagcgatca acctgaccgt tccgggttct gaacgttctt      300

acgacctgac cggtctgaaa ccgggtaccg aatacaccgt ttctatctac ggtgttctta      360

gaagcttccc aaaggc                                                      376


<210>  17
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  17
cggcggttag aacgcggcta caattaatac ataaccccat ccccctgttg acaattaatc       60

atcggctcgt ataatgtgtg gaattgtgag cggataacaa tttcacacag gaaacaggat      120

ctaccatgct g                                                           131


<210>  18
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  18
cggcggttag aacgcggcta caattaatac                                        30


<210>  19
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  19
ccaagacaga cgggcagagt cttcggtaac gcgagaaaca accaggtttt tcggcgccgg       60

cagcatggta gatcctgttt c                                                 81


<210>  20
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  20
ccgaagactc tgcccgtctg tcttgg                                            26


<210>  21
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  21
cagtggtctc acggattcct ggtactggat caggaaagag tcgaa                       45


<210>  22
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  22
catgcggtct cttccgaaaa agttggtgaa gcgatcgtcc tgaccgttcc gggt             54


<210>  23
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  23
ggtggtgaag atcgcagaca gcgggttag                                         29


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  24
cggcggttag aacgcggcta c                                                 21


<210>  25
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  25
aagatcagtt gcggccgcta gactagaacc gctgccaccg ccggtggtga agatcgcaga       60

c                                                                       61


<210>  26
<211>  485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (357)..(392)
<223>  N is any base

<400>  26
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctcgcgtt accgaagact      180

ctgcgcgtct gtcttggacc gcgccggacg cggcgttcga ctctttcctg atccagtacc      240

aggaatctga aaaagttggt gaagcgatcg tgctgaccgt tccgggttct gaacgttctt      300

acgacctgac cggtctgaaa ccgggtaccg aatacaccgt ttctatctac ggtgttnnnn      360

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nntctaaccc gctgtctgcg atcttcacca      420

ccggcggtca ccatcaccat caccatggca gcggttctag tctagcggcc gcaactgatc      480

ttggc                                                                  485


<210>  27
<211>  482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (357)..(389)
<223>  N is any base

<400>  27
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctcgcgtt accgaagact      180

ctgcgcgtct gtcttggacc gcgccggacg cggcgttcga ctctttcctg atccagtacc      240

aggaatctga aaaagttggt gaagcgatcg tgctgaccgt tccgggttct gaacgttctt      300

acgacctgac cggtctgaaa ccgggtaccg aatacaccgt ttctatctac ggtgttnnnn      360

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnt ctaacccgct gtctgcgatc ttcaccaccg      420

gcggtcacca tcaccatcac catggcagcg gttctagtct agcggccgca actgatcttg      480

gc                                                                     482


<210>  28
<211>  479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (357)..(386)
<223>  N is any base

<400>  28
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctcgcgtt accgaagact      180

ctgcgcgtct gtcttggacc gcgccggacg cggcgttcga ctctttcctg atccagtacc      240

aggaatctga aaaagttggt gaagcgatcg tgctgaccgt tccgggttct gaacgttctt      300

acgacctgac cggtctgaaa ccgggtaccg aatacaccgt ttctatctac ggtgttnnnn      360

nnnnnnnnnn nnnnnnnnnn nnnnnntcta acccgctgtc tgcgatcttc accaccggcg      420

gtcaccatca ccatcaccat ggcagcggtt ctagtctagc ggccgcaact gatcttggc       479


<210>  29
<211>  476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (357)..(383)
<223>  N is any base

<400>  29
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctcgcgtt accgaagact      180

ctgcgcgtct gtcttggacc gcgccggacg cggcgttcga ctctttcctg atccagtacc      240

aggaatctga aaaagttggt gaagcgatcg tgctgaccgt tccgggttct gaacgttctt      300

acgacctgac cggtctgaaa ccgggtaccg aatacaccgt ttctatctac ggtgttnnnn      360

nnnnnnnnnn nnnnnnnnnn nnntctaacc cgctgtctgc gatcttcacc accggcggtc      420

accatcacca tcaccatggc agcggttcta gtctagcggc cgcaactgat cttggc          476


<210>  30
<211>  473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (357)..(380)
<223>  N is any base

<400>  30
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctcgcgtt accgaagact      180

ctgcgcgtct gtcttggacc gcgccggacg cggcgttcga ctctttcctg atccagtacc      240

aggaatctga aaaagttggt gaagcgatcg tgctgaccgt tccgggttct gaacgttctt      300

acgacctgac cggtctgaaa ccgggtaccg aatacaccgt ttctatctac ggtgttnnnn      360

nnnnnnnnnn nnnnnnnnnn tctaacccgc tgtctgcgat cttcaccacc ggcggtcacc      420

atcaccatca ccatggcagc ggttctagtc tagcggccgc aactgatctt ggc             473


<210>  31
<211>  470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (357)..(377)
<223>  N is any base

<400>  31
gtgacacggc ggttagaacg cggctacaat taatacataa ccccatcccc ctgttgacaa       60

ttaatcatcg gctcgtataa tgtgtggaat tgtgagcgga taacaatttc acacaggaaa      120

caggatctac catgctgccg gcgccgaaaa acctggttgt ttctcgcgtt accgaagact      180

ctgcgcgtct gtcttggacc gcgccggacg cggcgttcga ctctttcctg atccagtacc      240

aggaatctga aaaagttggt gaagcgatcg tgctgaccgt tccgggttct gaacgttctt      300

acgacctgac cggtctgaaa ccgggtaccg aatacaccgt ttctatctac ggtgttnnnn      360

nnnnnnnnnn nnnnnnntct aacccgctgt ctgcgatctt caccaccggc ggtcaccatc      420

accatcacca tggcagcggt tctagtctag cggccgcaac tgatcttggc                 470


<210>  32

<400>  32
000

<210>  33
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  33

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ser Ile Ser Tyr Arg Glu Arg Ser Ala Trp Gly Glu Ala Ile Ala Leu 
        35                  40                  45              


Val Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Ile Glu Tyr Ile Val Gly Ile Ile Gly Val Lys Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Asn Pro Leu Arg Ala Asp Phe Thr Thr 
                85                  90  


<210>  34
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  34

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Tyr Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Ser Tyr Arg Glu Arg Ser Arg Glu Gly Glu Val Ile Ala Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ile Val Gly Ile Leu Gly Val Lys Gly Gly Arg Arg 
65                  70                  75                  80  


Ser Lys Pro Leu Arg Ala Gln Phe Thr Thr 
                85                  90  


<210>  35
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  35

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Glu Gly Tyr Arg Asn Asn Ala His Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Ala Ala 
65                  70                  75                  80  


Val Pro Arg Asn Tyr Tyr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


<210>  36
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  36

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Tyr Ile Arg Tyr Tyr Glu Gly Ser Gly Tyr Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Tyr Val Tyr Ile Gly Gly Val Lys Gly Gly Ser Pro 
65                  70                  75                  80  


Ser Ser Pro Leu Ser Ala Ile Phe Thr Thr Gly 
                85                  90      


<210>  37
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  37

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Lys Ile Gly Tyr Trp Glu Trp Arg Lys Tyr Gly Glu Ala Ile Glu Leu 
        35                  40                  45              


Asn Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Arg Val Leu Ile Tyr Gly Val Lys Gly Gly Ala Gly 
65                  70                  75                  80  


Ser His Pro Leu Arg Ala Leu Phe Thr Thr 
                85                  90  


<210>  38
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  38

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ser Ile Ser Tyr Arg Glu Arg Ser Ala Trp Gly Glu Ala Ile Ala Leu 
        35                  40                  45              


Val Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Ile Glu Tyr Ile Val Gly Ile Ile Gly Val Lys Gly Gly Leu Arg 
65                  70                  75                  80  


Ser Asn Pro Leu Arg Ala Asp Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro 
            100                 105                 110         


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
        115                 120                 125             


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu 
    130                 135                 140                 


Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu Thr Val Pro 
145                 150                 155                 160 


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
                165                 170                 175     


Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp Ser Trp Pro 
            180                 185                 190         


Leu Ser Ala Ile Phe Thr Thr 
        195                 


<210>  39
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  39

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Tyr Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Ala Ile Ser Tyr Arg Glu Arg Ser Arg Glu Gly Glu Val Ile Ala Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Ile Val Gly Ile Leu Gly Val Lys Gly Gly Arg Arg 
65                  70                  75                  80  


Ser Lys Pro Leu Arg Ala Gln Phe Thr Thr Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro 
            100                 105                 110         


Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser Ala Arg 
        115                 120                 125             


Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe His Ile Glu 
    130                 135                 140                 


Tyr Trp Glu Gln Ser Ile Val Gly Glu Ala Ile Val Leu Thr Val Pro 
145                 150                 155                 160 


Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly Thr Glu 
                165                 170                 175     


Tyr Arg Val Trp Ile Tyr Gly Val Lys Gly Gly Asn Asp Ser Trp Pro 
            180                 185                 190         


Leu Ser Ala Ile Phe Thr Thr 
        195                 


<210>  40
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Glu Glu Cys Val Cys Glu Asn Tyr Lys Leu Ala Val Asn Cys Phe 
1               5                   10                  15      


Val Asn Asn Asn Arg Gln Cys Gln Cys Thr Ser Val Gly Ala Gln Asn 
            20                  25                  30          


Thr Val Ile Cys Ser Lys Leu Ala Ala Lys Cys Leu Val Met Lys Ala 
        35                  40                  45              


Glu Met Asn Gly Ser Lys Leu Gly Arg Arg Ala Lys Pro Glu Gly Ala 
    50                  55                  60                  


Leu Gln Asn Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Glu Ser Gly 
65                  70                  75                  80  


Leu Phe Lys Ala Lys Gln Cys Asn Gly Thr Ser Met Cys Trp Cys Val 
                85                  90                  95      


Asn Thr Ala Gly Val Arg Arg Thr Asp Lys Asp Thr Glu Ile Thr Cys 
            100                 105                 110         


Ser Glu Arg Val Arg Thr Tyr Trp Ile Ile Ile Glu Leu Lys His Lys 
        115                 120                 125             


Ala Arg Glu Lys Pro Tyr Asp Ser Lys Ser Leu Arg Thr Ala Leu Gln 
    130                 135                 140                 


Lys Glu Ile Thr Thr Arg Tyr Gln Leu Asp Pro Lys Phe Ile Thr Ser 
145                 150                 155                 160 


Ile Leu Tyr Glu Asn Asn Val Ile Thr Ile Asp Leu Val Gln Asn Ser 
                165                 170                 175     


Ser Gln Lys Thr Gln Asn Asp Val Asp Ile Ala Asp Val Ala Tyr Tyr 
            180                 185                 190         


Phe Glu Lys Asp Val Lys Gly Glu Ser Leu Phe His Ser Lys Lys Met 
        195                 200                 205             


Asp Leu Thr Val Asn Gly Glu Gln Leu Asp Leu Asp Pro Gly Gln Thr 
    210                 215                 220                 


Leu Ile Tyr Tyr Val Asp Glu Lys Ala Pro Glu Phe Ser Met Gln Gly 
225                 230                 235                 240 


Leu Lys 
        


<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45

<400>  45
000

<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59

<400>  59
000

<210>  60

<400>  60
000

<210>  61

<400>  61
000

<210>  62

<400>  62
000

<210>  63
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  63

Gly Ser Gly Ser 
1               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  64

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210>  65
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  65

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  66

Ala Pro Ala Pro 
1               


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  67

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10  


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  68

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro 
            20  


<210>  69
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  69

Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro 
            20                  25                  30          


Ala Pro Ala Pro Ala Pro Ala Pro 
        35                  40  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  70

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala Ala Ala 
            20                  25                  


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  71

Gly Gly Gly Gly Ser 
1               5   


