               SEQUENCE LISTING

<110> Medizinische Hochschule Hannover

<120> Non-coding RNA protecting against Heart Failure

<130> AB3197 PCT

<150> EP 19 20 3627.5
<151> 2019-10-16

<160> 91

<170> BiSSAP 1.3.6

<210> 1
<211> 552
<212> RNA
<213> Homo sapiens


<220> 
<223> RNA sequence

<400> 1
ugugucccgg cauggauauc cggaacaacc ucacuagguu gcaugagcug gagaauugcu      60

cugucaucga aggacacuug cagauacucu ugauguucaa aacgaggccc gaagauuucc     120

gagaccucag uuuccccaaa cucaucauga ucacugauua cuugcugcuc uuccgggucu     180

augggcucga gagccugaag gaccuguucc ccaaccucac ggucauccgg ggaucacgac     240

uguucuuuaa cuacgcgcug gucaucuucg agaugguuca ccucaaggaa cucggccucu     300

acaaccugau gaacaucacc cgggguucug uccgcaucga gaagaacaau gagcucuguu     360

acuuggccac uaucgacugg ucccguaucc uggauuccgu ggaggauaau uacaucgugu     420

ugaacaaaga ugacaacgag gaguguggag acaucugucc ggguaccgcg aagggcaaga     480

ccaacugccc cgccaccguc aucaacgggc aguuugucga acgauguugg acucauaguc     540

acugccagaa ag                                                         552


<210> 2
<211> 552
<212> RNA
<213> Mus musculus


<220> 
<223> RNA sequence

<400> 2
ugugcccugg uauggacauc cggaacaacc ugaccaggcu acaugagcug gagaacugcu      60

cagucauuga gggccaucug cagauccucc ugauguucaa gaccagaccc gaagauuucc     120

gagaccucag uuuccccaaa cucaucauga ucacagauua ccugcuucuc uuccgugucu     180

auggucugga aagucugaaa gaccucuucc caaaucucac agucauccga ggcucccguc     240

ucuucuucaa cuaugcccug guuaucuucg agauggucca ccugaaggag cuggggcuuu     300

auaaccucau gaacaucacc cggggcucug uccgcaucga gaagaauaau gagcucugcu     360

accuggccac uaucgacugg ucccguaucc uggauucugu ggaggacaac uacauuguac     420

ugaacaaaga ugacaacgag gaaugugggg augucugucc aggcaccgcc aagggcaaga     480

ccaacugucc ugccacuguc aucaaugggc aguuugugga acggugcugg acacacaguc     540

auugucagaa ag                                                         552


<210> 3
<211> 552
<212> RNA
<213> Rattus norvegicus


<220> 
<223> RNA sequence

<400> 3
ugugcccggg aauggacauc cggaacaacc ugaccagguu gcaugagcug gagaacugcu      60

cggucauuga gggccaucug cagauccucu ugauguucaa gaccagaccc gaagauuucc     120

gagaccucag uuuccccaaa cucaucauga ucacagacua ccugcuucuu uuccgugucu     180

auggccuaga aagucuaaaa gaccucuucc caaaccucac agucauccga ggcucccguc     240

ucuucuucaa cuaugcccug gucaucuucg agauggucca ccugaaggag cugggucuuu     300

acaaccucau gaacaucacc cggggcucug uccgcaucga gaagaauaau gaacucugcu     360

accuggccac uaucgacugg ucccgcaucc uggauuccgu ggaggacaac uacauuguac     420

ugaacaaaga ugacaaugag gaaugugggg acgucugucc aggcacagcc aagggcaaga     480

ccaacugccc ugccaccguc aucaaugggc aguuugugga acggugcugg acacacaguc     540

auugucagaa ag                                                         552


<210> 4
<211> 306
<212> DNA
<213> Homo sapiens


<220> 
<223> ALU repeat upstream

<400> 4
ttatcttttt tttttttttt ttttgagaag gagtttccct ctggttgccc agggtggagt     60

gcaatggcac aatctcggct cactgcaacc tccgcctccc gggttcaagt gattctcctg    120

cctcagcctc ccaagtagct gggactacag gcgtgcaccg ccacgcccgg ctaattttgt    180

atttttagta gagatggggt ttcaccgtgt tggtcaggtt ggtctcgaac tcctgacctc    240

aagtggtcca cccgcctcag cctccccaag tgctgggatt acaggcctga gccaccgtgc    300

ccggcc                                                               306


<210> 5
<211> 80
<212> DNA
<213> Homo sapiens


<220> 
<223> ALU repeat downstream

<400> 5
gaagaagaag tgaaacaact cagggcaagc actcaaacag tgcctgagac atagtaagtg     60

ctgcactaat gtcagctatt                                                 80


<210> 6
<211> 966
<212> DNA
<213> Homo sapiens


<220> 
<223> circINSR left (upstream) flanking sequence (circular exon2)

<400> 6
ttatcttttt tttttttttt ttttgagaag gagtttccct ctggttgccc agggtggagt      60

gcaatggcac aatctcggct cactgcaacc tccgcctccc gggttcaagt gattctcctg     120

cctcagcctc ccaagtagct gggactacag gcgtgcaccg ccacgcccgg ctaattttgt     180

atttttagta gagatggggt ttcaccgtgt tggtcaggtt ggtctcgaac tcctgacctc     240

aagtggtcca cccgcctcag cctccccaag tgctgggatt acaggcctga gccaccgtgc     300

ccggcctgga aatcatctta atgcccaata acaggaatgg ttaaggaaac cttcagtaga     360

cacgacagat tcctgaagat cactagaagg aacaaccccc aataaactac tctcggcgac     420

atgcgttgtg gaataagatg aatgttttgc ttttttttcg tttacaagtg tctttttcca     480

aatgtctatt ataagcaata tcacttctat aatcagataa gaactaaact atttttttaa     540

aaaaaccgaa tctacagttt tccactcctt ttcctctccc aagcaagaag aacattcact     600

gactagcaca ggcggtggca aactgctgcc ctcgagcaaa atccggccca cgacttgttt     660

ttgtaaataa agttttattg aaacacagcc acagtcatac atttatgcat gcctgtggct     720

gcttgtccaa tacagtggca gaattgagtc gttgcatcag agaccatatg gcctgcaaaa     780

tctgaagtat ctactatctg agtctttaca gaaaatgtct gccactccct gggctagtga     840

atgccaccac ccactattcc ccggccccta cctaatgacc atttaacatt tttaagccat     900

aaaacatttt aagctttcta gaacaaggca cgagacactg cttagaaccc tgtatccccg     960

gcgtac                                                                966


<210> 7
<211> 830
<212> DNA
<213> Homo sapiens


<220> 
<223> circINSR right (downstream) flanking sequence (circular exon2)

<400> 7
ctacaagaga aaatgaacag aaagcaagac aggtgagcag acgcacggtg gatgcatcag      60

aaggatcagg ggcagagccg gcttcatgga caggaaacct gggccctgtg ttttcatccc     120

gggccctgta aactctgcag ccagccggga tgagtagctt tctctgtaaa gtacccatgc     180

ctaagtaatt actttcaaaa cgccaagaaa ataattcttt tggcaagccc tgttaaaatc     240

cttaaaatca ccacctctga aatgatgcag tcgggacaat gggattacag gggattgagt     300

aacgcggcag gtgcagaagg agaaagggga actgtctcca gtgcgtcaac atagaagatc     360

ttcaggagat aatttacggg gataaaggtg cccgcggtca gaaatggggc aaggaaagct     420

aaatgtattt gttttgtcaa tcctcccacc tcgctggctg actttccttc ccggactgct     480

ctcctgacct gcaatcaaga cctaattacc ttttacctgg gtgtggtgag ggcttcccag     540

ggagcccgat ctccattgcc caaatgccct gagttctcat tctcctgaag gcggtccctc     600

ccaggcccca acgcccacca tggctcccca tcatcctgca cttccctcaa gattctgccc     660

ctacatcccc tgcacaccac taaacaggcc tgcccacaac tcttgcacaa ctccaagact     720

cctatcctcc tctgtaacat ggcttatatg gaagaagaag tgaaacaact cagggcaagc     780

actcaaacag tgcctgagac atagtaagtg ctgcactaat gtcagctatt                830


<210> 8
<211> 552
<212> DNA
<213> Homo sapiens


<220> 
<223> DNA (genome) sequence

<400> 8
ctttctggca gtgactatga gtccaacatc gttcgacaaa ctgcccgttg atgacggtgg      60

cggggcagtt ggtcttgccc ttcgcggtac ccggacagat gtctccacac tcctcgttgt     120

catctttgtt caacacgatg taattatcct ccacggaatc caggatacgg gaccagtcga     180

tagtggccaa gtaacagagc tcattgttct tctcgatgcg gacagaaccc cgggtgatgt     240

tcatcaggtt gtagaggccg agttccttga ggtgaaccat ctcgaagatg accagcgcgt     300

agttaaagaa cagtcgtgat ccccggatga ccgtgaggtt ggggaacagg tccttcaggc     360

tctcgagccc atagacccgg aagagcagca agtaatcagt gatcatgatg agtttgggga     420

aactgaggtc tcggaaatct tcgggcctcg ttttgaacat caagagtatc tgcaagtgtc     480

cttcgatgac agagcaattc tccagctcat gcaacctagt gaggttgttc cggatatcca     540

tgccgggaca ca                                                         552


<210> 9
<211> 95
<212> DNA
<213> Mus musculus


<220> 
<223> ALU repeat upstream

<400> 9
acagtgtcct cctgtgacac aggttatctt taaactcata atcctcctgc ctcagcctct     60

ttatcaatgg agtttaagtg gtcaccatgc ctagc                                95


<210> 10
<211> 145
<212> DNA
<213> Mus musculus


<220> 
<223> ALU repeat downstream

<400> 10
ccgggtgtgg tggcgcacgc ctttaatccc agcactcggg aggcagaggc aggtagattt     60

ctgagttcta ggccagcctg ttctacagag tgagtttcag gacagccagg gctatatagt    120

gaaaccctgt ctcaaaaaac caaaa                                          145


<210> 11
<211> 1188
<212> DNA
<213> Mus musculus


<220> 
<223> circINSR left (upstream) flanking sequence (circular exon2)

<400> 11
ctcactgggg aattctatga agggctatgt accctcactg ggagatctag gcaggggttc      60

tacagctgaa cagtgtcctc ctgtgacaca ggttatcttt aaactcataa tcctcctgcc     120

tcagcctctt tatcaatgga gtttaagtgg tcaccatgcc tagcacatca tatatcatta     180

tctgtcatcc acagttaggg caatggctgg tatcataaag acaagaagta acaaatacta     240

gtgagaatat taaggaaggg gagcgtttac atactgttaa caaccaggaa gattgaaaag     300

gagtcctagt tctttttctt cctcaagtct tttggttgac ttatagacga atgggtttca     360

cgcgatgtca tcttatgtgc atcgatcgta ccttgtttat cacctctgct gcattttctg     420

cactcagctc tctgctcacc cattagtatc tttctttact caactggtct ctcttctgtt     480

cctgccgtgc acatatacag tgcatatata tctaattatt tcattctttc tggctactac     540

cccattgttt ctatatccca catttttgat cttatctctt attattatta ctttcttgag     600

acagggtctc aaatagccta ggcaggcata gtctagctcc cacccattga ccgcttattt     660

cataacttgg ttattgtgaa gatgcctcta tatgatatgt gccacatttt cttcatctgt     720

ttttctgttg gcagacattt cctcagctgt ggtgaacaga gcaacagtga gagtagatgt     780

gcagtggagt gtctgtgata tgctgaccta gagtgctctg ggacatacac ccctggtttt     840

tttttttttt ttttgtgtgt gtgtgagaag ccaagaccaa tttcaagggt tagttgttcc     900

tcaggtgccc tccatcttgt ctcttgagac agggtctctt actggcctgg agttcactaa     960

tagaagtagc ccagtgagcc ctggggatcc atctatctct aaatgccccc tgccctcaca    1020

gacatattat gttacacaag cttattacat gggtcctggg catagatgct aggccctcat    1080

ccctgtacaa cactttgttg tctccccagt tctaggttct agttccgtta gccgttctag    1140

agtccctggc tcacctactt tgctttgcct ttattatctg ccttctag                 1188


<210> 12
<211> 736
<212> DNA
<213> Mus musculus


<220> 
<223> circINSR right (downstream) flanking sequence (circular exon2)

<400> 12
gtatgctgaa ggcagtgcct tttaaagatt tctccgtggt tagtatgccc aggagaagta      60

gactcctgta aaagtttagg tgatggaggt tgtagggtac aaaccctaga atctccataa     120

aaaatacatt cgtcccctta tctgcgaggc atacctattt gatgttgtac acttaactgt     180

gggttactga gactgtagga agcagaattt ctgatgggga gagatgaatg cgtgtactga     240

tacttggcca ttgcagtagg aaggtagcca cagttaggta tcaagatatg gtgttttttt     300

tttaatgtgg cttatatgta aaaaaatttt tatatgcaaa aaataaatag ggggccagat     360

ttcttttggg ggagagctgt ttgccaccct ctgtgctgga tagtgactgt ttctgtggtc     420

ctctgctttg ttggggagta gactatgcaa gagtatgggt ttggcttagt gtttttctta     480

tctgatcata gaagtcaatt tgttagagat actcagaaaa agaaatgtaa aaattcagct     540

ttgaccgggt gtggtggcgc acgcctttaa tcccagcact cgggaggcag aggcaggtag     600

atttctgagt tctaggccag cctgttctac agagtgagtt tcaggacagc cagggctata     660

tagtgaaacc ctgtctcaaa aaaccaaaaa accaaaacaa acaaacaaaa aaaccccagc     720

tttgatgagg gtagct                                                     736


<210> 13
<211> 552
<212> DNA
<213> Mus musculus


<220> 
<223> DNA (genome) sequence

<400> 13
ctttctgaca atgactgtgt gtccagcacc gttccacaaa ctgcccattg atgacagtgg      60

caggacagtt ggtcttgccc ttggcggtgc ctggacagac atccccacat tcctcgttgt     120

catctttgtt cagtacaatg tagttgtcct ccacagaatc caggatacgg gaccagtcga     180

tagtggccag gtagcagagc tcattattct tctcgatgcg gacagagccc cgggtgatgt     240

tcatgaggtt ataaagcccc agctccttca ggtggaccat ctcgaagata accagggcat     300

agttgaagaa gagacgggag cctcggatga ctgtgagatt tgggaagagg tctttcagac     360

tttccagacc atagacacgg aagagaagca ggtaatctgt gatcatgatg agtttgggga     420

aactgaggtc tcggaaatct tcgggtctgg tcttgaacat caggaggatc tgcagatggc     480

cctcaatgac tgagcagttc tccagctcat gtagcctggt caggttgttc cggatgtcca     540

taccagggca ca                                                         552


<210> 14
<211> 161
<212> DNA
<213> Rattus norvegicus


<220> 
<223> ALU repeat upstream

<400> 14
gggaacagag agatagctca gtgggtaaag acgcttgcca ccagccagat cgcctccatt     60

tgatcctcta gacccacaca tgaggaagga gaattattct ctaacctcca tgttggtcat    120

ggcatcccca tattcacatt tataatacat agacacacac a                        161


<210> 15
<211> 247
<212> DNA
<213> Rattus norvegicus


<220> 
<223> ALU repeat downstream

<400> 15
gagttgggga gacaacaaag tgtttgttgt acaggtgtga gggcctgaca tctatgccca     60

agaccatgtg ataagctagt gcaacaaaat atgtctgtga gggctgcagg ccttcagaga    120

cagatggatc cccagggttc actgggtttc ttctactagt gaactcctgg ccagtaagag    180

accctgtctc aagaaacaag atggggggca tgaggaaaaa ctgacccttg aaattggtct    240

tggcctc                                                              247


<210> 16
<211> 1557
<212> DNA
<213> Rattus norvegicus


<220> 
<223> circINSR left (upstream) flanking sequence (circular exon2)

<400> 16
gggaacagag agatagctca gtgggtaaag acgcttgcca ccagccagat cgcctccatt      60

tgatcctcta gacccacaca tgaggaagga gaattattct ctaacctcca tgttggtcat     120

ggcatcccca tattcacatt tataatacat agacacacac atggagagat aaatgatgtt     180

ggtcataatg ataaagatag atagattata gatcgatgat gggtagatag gtaggtagat     240

aggtagatag atagatagct gataggtaga tagatgatag gtagatagat agatagatag     300

atagatagat agatagctga taggtagatt gatagataga tagataggta ggtagatagc     360

tgataggtag atagatagat agatagatag atagatagat agatagataa tagttagata     420

gctgataggt agatagataa taggtagata gatgataggt aggtagggag agagagatag     480

ctgataggta gatagatgat aggtagatag ataggcagat agctgataag tagatagata     540

gatgcataaa tagatgatag atagctgata gatagataga tagatagata gctgatagat     600

agatagatag atagatagat agatagatag atagatagat aggtagatag atagatagct     660

ggtatataga tagatagaag cagatagata gatagataga tagatagata gatagataga     720

tagatagata gctgataggt agatagatga tagatagata gatagataga tagatagata     780

gatagataga taataggtag ataggtagat agttgatagg tagatagata gatgataggt     840

agatagatag gcagatagct gataggtaaa tagatagatg cataaataga tgatggatag     900

atagatagat agatagatag atagatagac agacagctgg tagatagata gctgatagat     960

agatagatag acagacagac agacagctgg taaatagata gctgatagat agatagatag    1020

atagatagat agatagatag atagatgaat ttttacattt ccttttctga gtatctctta    1080

caaattgact tctatgatca gataagaaaa gcatgctaag tcaaatccat actcctgcat    1140

agaccactcc tcaatcaagc agaggaccac agagacatca ctatccagca tagagggtgg    1200

caaacagctc ccaaaagagt ctgaccccct atttattttt catatataaa gtttttttac    1260

acatatgaac acatatgtaa aaaaaatctt gatagctaac tgtggccact tgcctactac    1320

aatggccaag tttcagttcc atcagagatt tcactcctca cagtctcaat aacccacagt    1380

taactgtaca atatccaatg ggtatacctc acaggtaggg ggatgcatgt atttttatgg    1440

agatcctagg gtttggaccc cacagccttc atcacctaaa cgttcccagg agtctactgc    1500

ccctgggtct actaaccatg aaggaatctt tagaaggcgt tgccaccttc aacatac       1557


<210> 17
<211> 77
<212> DNA
<213> Rattus norvegicus


<220> 
<223> circINSR right (downstream) flanking sequence (circular exon2)

<400> 17
actagaggac agataatgaa agccaagcaa agtaggtcag ccagggactc tagagctgct     60

aatggaacta gagccta                                                    77


<210> 18
<211> 552
<212> DNA
<213> Rattus norvegicus


<220> 
<223> DNA (genome) sequence

<400> 18
ctttctgaca atgactgtgt gtccagcacc gttccacaaa ctgcccattg atgacggtgg      60

cagggcagtt ggtcttgccc ttggctgtgc ctggacagac gtccccacat tcctcattgt     120

catctttgtt cagtacaatg tagttgtcct ccacggaatc caggatgcgg gaccagtcga     180

tagtggccag gtagcagagt tcattattct tctcgatgcg gacagagccc cgggtgatgt     240

tcatgaggtt gtaaagaccc agctccttca ggtggaccat ctcgaagatg accagggcat     300

agttgaagaa gagacgggag cctcggatga ctgtgaggtt tgggaagagg tcttttagac     360

tttctaggcc atagacacgg aaaagaagca ggtagtctgt gatcatgatg agtttgggga     420

aactgaggtc tcggaaatct tcgggtctgg tcttgaacat caagaggatc tgcagatggc     480

cctcaatgac cgagcagttc tccagctcat gcaacctggt caggttgttc cggatgtcca     540

ttcccgggca ca                                                         552


<210> 19
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Scramble siRNA

<400> 19
agguagugua aucgccuug                                                 19


<210> 20
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Circ-Insr siRNA1

<400> 20
gaaagugugc ccugguaug                                                 19


<210> 21
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Circ-Insr siRNA2

<400> 21
gucauuguca gaaagugug                                                 19


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Circ-Insr (mmu/rno/hsa): forward

<400> 22
ctgtcctgcc actgtcatca a                                              21


<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Circ-Insr (mmu/rno/hsa): reverse

<400> 23
tcttcgggtc tggtcttgaa c                                              21


<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Linear-Insr (mmu/rno/hsa): forward

<400> 24
tcacctgagt ccctgaagg                                                 19


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Linear-Insr (mmu/rno/hsa): reverse

<400> 25
gcatcaggtc agtgagtctc                                                20


<210> 26
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Pre-Insr (mmu/rno/hsa): forward

<400> 26
gatccatcta tctctaaatg ccc                                            23


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Pre-Insr (mmu/rno/hsa): reverse

<400> 27
tcttcgggtc tggtcttgaa c                                              21


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18s (mmu/rno): forward

<400> 28
gtaacccgtt gaaccccatt                                                20


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18s (mmu/rno): reverse

<400> 29
ccatccaatc ggtagtagcg                                                20


<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18s (hsa): forward

<400> 30
agtccctgcc ctttgtacac a                                              21


<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18s (hsa): reverse

<400> 31
gatccgaggg cctcactaaa c                                              21


<210> 32
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> Xist (mmu): forward

<400> 32
tgcctggatt tagaggag                                                  18


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Xist (mmu): reverse

<400> 33
ctccacctag ggatcgtcaa                                                20


<210> 34
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> WNT6 (mmu): forward

<400> 34
gcaagactgg gggttcgag                                                 19


<210> 35
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> WNT6 (mmu): reverse

<400> 35
cctgacaacc acactgtagg ag                                             22


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Brca1 (mmu/rno): forward

<400> 36
atctgccgtc caaattcaag                                                20


<210> 37
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Brca1 (mmu/rno): reverse

<400> 37
ttccaaacag atcggacact c                                              21


<210> 38
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> SSBP1 (mmu/rno): forward

<400> 38
caacaaatga gatgtggcga tca                                            23


<210> 39
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> SSBP1 (mmu/rno): reverse

<400> 39
acgagcttct taccagctat ga                                             22


<210> 40
<211> 2476
<212> DNA
<213> Artificial Sequence


<220> 
<223> Circ-Insr overexpression transcript sequence

<400> 40
ctcactgggg aattctatga agggctatgt accctcactg ggagatctag gcaggggttc      60

tacagctgaa cagtgtcctc ctgtgacaca ggttatcttt aaactcataa tcctcctgcc     120

tcagcctctt tatcaatgga gtttaagtgg tcaccatgcc tagcacatca tatatcatta     180

tctgtcatcc acagttaggg caatggctgg tatcataaag acaagaagta acaaatacta     240

gtgagaatat taaggaaggg gagcgtttac atactgttaa caaccaggaa gattgaaaag     300

gagtcctagt tctttttctt cctcaagtct tttggttgac ttatagacga atgggtttca     360

cgcgatgtca tcttatgtgc atcgatcgta ccttgtttat cacctctgct gcattttctg     420

cactcagctc tctgctcacc cattagtatc tttctttact caactggtct ctcttctgtt     480

cctgccgtgc acatatacag tgcatatata tctaattatt tcattctttc tggctactac     540

cccattgttt ctatatccca catttttgat cttatctctt attattatta ctttcttgag     600

acagggtctc aaatagccta ggcaggcata gtctagctcc cacccattga ccgcttattt     660

cataacttgg ttattgtgaa gatgcctcta tatgatatgt gccacatttt cttcatctgt     720

ttttctgttg gcagacattt cctcagctgt ggtgaacaga gcaacagtga gagtagatgt     780

gcagtggagt gtctgtgata tgctgaccta gagtgctctg ggacatacac ccctggtttt     840

tttttttttt ttttgtgtgt gtgtgagaag ccaagaccaa tttcaagggt tagttgttcc     900

tcaggtgccc tccatcttgt ctcttgagac agggtctctt actggcctgg agttcactaa     960

tagaagtagc ccagtgagcc ctggggatcc atctatctct aaatgccccc tgccctcaca    1020

gacatattat gttacacaag cttattacat gggtcctggg catagatgct aggccctcat    1080

ccctgtacaa cactttgttg tctccccagt tctaggttct agttccgtta gccgttctag    1140

agtccctggc tcacctactt tgctttgcct ttattatctg ccttctagtg tgccctggta    1200

tggacatccg gaacaacctg accaggctac atgagctgga gaactgctca gtcattgagg    1260

gccatctgca gatcctcctg atgttcaaga ccagacccga agatttccga gacctcagtt    1320

tccccaaact catcatgatc acagattacc tgcttctctt ccgtgtctat ggtctggaaa    1380

gtctgaaaga cctcttccca aatctcacag tcatccgagg ctcccgtctc ttcttcaact    1440

atgccctggt tatcttcgag atggtccacc tgaaggagct ggggctttat aacctcatga    1500

acatcacccg gggctctgtc cgcatcgaga agaataatga gctctgctac ctggccacta    1560

tcgactggtc ccgtatcctg gattctgtgg aggacaacta cattgtactg aacaaagatg    1620

acaacgagga atgtggggat gtctgtccag gcaccgccaa gggcaagacc aactgtcctg    1680

ccactgtcat caatgggcag tttgtggaac ggtgctggac acacagtcat tgtcagaaag    1740

gtatgctgaa ggcagtgcct tttaaagatt tctccgtggt tagtatgccc aggagaagta    1800

gactcctgta aaagtttagg tgatggaggt tgtagggtac aaaccctaga atctccataa    1860

aaaatacatt cgtcccctta tctgcgaggc atacctattt gatgttgtac acttaactgt    1920

gggttactga gactgtagga agcagaattt ctgatgggga gagatgaatg cgtgtactga    1980

tacttggcca ttgcagtagg aaggtagcca cagttaggta tcaagatatg gtgttttttt    2040

tttaatgtgg cttatatgta aaaaaatttt tatatgcaaa aaataaatag ggggccagat    2100

ttcttttggg ggagagctgt ttgccaccct ctgtgctgga tagtgactgt ttctgtggtc    2160

ctctgctttg ttggggagta gactatgcaa gagtatgggt ttggcttagt gtttttctta    2220

tctgatcata gaagtcaatt tgttagagat actcagaaaa agaaatgtaa aaattcagct    2280

ttgaccgggt gtggtggcgc acgcctttaa tcccagcact cgggaggcag aggcaggtag    2340

atttctgagt tctaggccag cctgttctac agagtgagtt tcaggacagc cagggctata    2400

tagtgaaacc ctgtctcaaa aaaccaaaaa accaaaacaa acaaacaaaa aaaccccagc    2460

tttgatgagg gtagct                                                    2476


<210> 41
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> pcDNA3.1 plasmid system: forward with EcorI

<400> 41
ctcactgggg aattctatga agg                                            23


<210> 42
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> pcDNA3.1 plasmid system: reverse with xhoI

<400> 42
ccgctcgagt agctaccctc atcaaagctg                                     30


<210> 43
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV plasmid system: forward with EcorI

<400> 43
ctcactgggg aattctatga agg                                            23


<210> 44
<211> 29
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV plasmid system: reverse with SalI

<400> 44
ccgtcgacta gctaccctca tcaaagctg                                      29


<210> 45
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgRNA1

<400> 45
acggaactag aacctagaac tgg                                            23


<210> 46
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgRNA2

<400> 46
gtcctgccac tgtcatcaat ggg                                            23


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Checking primer: forward

<400> 47
cggggctggc ttaagagttt                                                20


<210> 48
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Checking primer: reverse

<400> 48
agtttgatcc tctatgccca c                                              21


<210> 49
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> Anti-linear-Insr probe

<400> 49
aaaattagac aggccttgat aaggttgctc agc                                  33


<210> 50
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> Anti-circ-Insr probe

<400> 50
aaaccatacc agggcacact ttctgacaat gac                                  33


<210> 51
<211> 39
<212> DNA
<213> Artificial Sequence


<220> 
<223> Back-splicing Site

<400> 51
gtcagtaaca gtctttcaca cgggccctta cctgtaggc                            39


<210> 52
<211> 144
<212> DNA
<213> Artificial Sequence


<220> 
<223> Back splice site

<400> 52
ctggaccaca gtcattgtca gaaagtgtgc cctggtatgg acatccggaa caacctgacc     60

aggctacatg agctggagaa ctgctcagtc attgagggcc atctgcagat cctcctgatg    120

ttcaagacca gacccgaagt aaaa                                           144


<210> 53
<211> 43
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgRNA 1

<400> 53
gcttattaca tgggtcctgg gcatagatgc taggccctca tcc                       43


<210> 54
<211> 34
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgRNA 2

<400> 54
ccaactgtcc tgccactgtc atcaatgggc agtt                                 34


<210> 55
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgRNA 1

<400> 55
gcttattaca tgggtcctgg gca                                            23


<210> 56
<211> 10
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgRNA 2

<400> 56
atgggcagtt                                                           10


<210> 57
<211> 543
<212> DNA
<213> Artificial Sequence


<220> 
<223> SSBP1-Flag overexpression transcript sequence

<400> 57
gaattctcta gagccaccat gtttcgaaga cctgtgttac aggtatttcg tcagtttgta      60

agacatgagt ctgaagtagc cagcagtttg gttcttgaac gatctctgaa tcgtgttcag     120

ttacttggac gagtaggtca ggaccctgtc atgagacagg tggaaggaaa aaacccagtc     180

acaatatttt ctctagcaac aaatgagatg tggcgatcag gggatagtga agtataccaa     240

atgggtgacg ttagtcagaa gacgacgtgg cacagaatat cagtgtttcg accaggcctc     300

agagatgtgg catatcagta tgtgaaaaag ggggctcgta tatttgtgga agggaaagtg     360

gactatggcg agtacatgga taaaaacaat gtgaggcggc aagcaacaac aatcatagct     420

gataacatta tatttctgag tgaccagaca aaagaaaagg cagattacaa ggatgacgac     480

gataaggact ataaggacga tgatgacaag gactacaaag atgatgacga taaataggga     540

tcc                                                                   543


<210> 58
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mt-CYTB forward primer

<400> 58
ggctacgtcc ttccatgagg ac                                             22


<210> 59
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Mt-CYTB reverse primer

<400> 59
gaagccccct caaattcatt cgac                                           24


<210> 60
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACTB forward primer

<400> 60
catctcctgc tcgaagtcta g                                              21


<210> 61
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACTB reverse primer

<400> 61
atcatgtttg agaccttcaa caccc                                          25


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-PGC1-alpha-F

<400> 62
ggagcaataa agcaaagagc a                                              21


<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-PGC1-alpha-R

<400> 63
gtgtgaggag ggtcatcgtt                                                20


<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-NRF1-F

<400> 64
ttgatggaca cttgggtagc                                                20


<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-NRF1-R

<400> 65
gccagaagga ctgaaagcag                                                20


<210> 66
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TFAM-F

<400> 66
cagagttgtc attgggattg g                                              21


<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TFAM-R

<400> 67
ttcagtgggc agaagtccat                                                20


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-GLUT4-F

<400> 68
gtatgttgcg gatgctatgg                                                20


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-GLUT4-R

<400> 69
cctctggttt caggcactct                                                20


<210> 70
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-UCP3-F

<400> 70
cacggatgtg gtgaaggtc                                                 19


<210> 71
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-UCP3-R

<400> 71
ctggcgatgg ttctgtagg                                                 19


<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-NRF2B-F

<400> 72
gccgtttagt ctccgtgaac                                                20


<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-NRF2B-R

<400> 73
tcgtactccc aaggctgtgt                                                20


<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-NRF2A-F

<400> 74
agcagaagca catctcgttg                                                20


<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-NRF2A-R

<400> 75
cccatctcgt cacttgctct                                                20


<210> 76
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TFB1M-F

<400> 76
aaggaagtgg cggagagac                                                 19


<210> 77
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TFB1M-R

<400> 77
gggattgtaa agaggtgctc                                                20


<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TFB2M-F

<400> 78
tgcggatgga gagttacaag                                                20


<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TFB2M-R

<400> 79
acacctgctg accaaggaac                                                20


<210> 80
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-POLG-F

<400> 80
ctcctacctg cctgtcaacc                                                20


<210> 81
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-POLG-R

<400> 81
gctccatcag cgacttcttc                                                20


<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TOP1MT-F

<400> 82
ccaaggtgtt tcggacctac                                                20


<210> 83
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TOP1MT-R

<400> 83
gtttgcccgg ttgtaagcta                                                20


<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-SSBP1-F

<400> 84
agccagcagt ttggttcttg                                                20


<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-SSBP1-R

<400> 85
atcgccacat ctcatttgtt                                                20


<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TWINKLE-F

<400> 86
gaggacaggg aggaggtctt                                                20


<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TWINKLE-R

<400> 87
tggtaaggcc aaacatcaca                                                20


<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-16SRNA-F

<400> 88
gaccctgctt gtagctgacc                                                20


<210> 89
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-16SRNA-R

<400> 89
accctgatcc ttgagactgg                                                20


<210> 90
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TBP2-F

<400> 90
tgtgaatact ggtgctgag                                                 19


<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rno-TBP2-F

<400> 91
ggcatgagac aagacctata                                                20


