﻿                         SEQUENCE LISTING

<110>  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
       UNIVERSITE DE PARIS 
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
       SORBONNE UNIVERSITE
 
<120>  Cellule souche humaine génétiquement modifiée exprimant une 
       protéine cytochrome P450 2B6 humaine mutante et son utilisation 
       dans le traitement du cancer

<130>  FID2020-000138-WO

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Val Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Met Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Trp Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                485                 490     


<210>  2
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Gln Thr Leu Thr Ser Ser Val Arg Glu Ser Ser Phe Val Glu Lys 
1               5                   10                  15      


Met Lys Lys Thr Gly Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln Thr 
            20                  25                  30          


Gly Thr Ala Glu Glu Phe Ala Asn Arg Leu Ser Lys Asp Ala His Arg 
        35                  40                  45              


Tyr Gly Met Arg Gly Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu Ala 
    50                  55                  60                  


Asp Leu Ser Ser Leu Pro Glu Ile Asp Asn Ala Leu Val Val Phe Cys 
65                  70                  75                  80  


Met Ala Thr Tyr Gly Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp Phe 
                85                  90                  95      


Tyr Asp Trp Leu Gln Glu Thr Asp Val Asp Leu Ser Gly Val Lys Phe 
            100                 105                 110         


Ala Val Phe Gly Leu Gly Asn Lys Thr Tyr Glu His Phe Asn Ala Met 
        115                 120                 125             


Gly Lys Tyr Val Asp Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg Ile 
    130                 135                 140                 


Phe Glu Leu Gly Leu Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp Phe 
145                 150                 155                 160 


Ile Thr Trp Arg Glu Gln Phe Trp Pro Ala Val Cys Glu His Phe Gly 
                165                 170                 175     


Val Glu Ala Thr Gly Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu Val 
            180                 185                 190         


Val His Thr Asp Ile Asp Ala Ala Lys Val Tyr Met Gly Glu Met Gly 
        195                 200                 205             


Arg Leu Lys Ser Tyr Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys Asn 
    210                 215                 220                 


Pro Phe Leu Ala Ala Val Thr Thr Asn Arg Lys Leu Asn Gln Gly Thr 
225                 230                 235                 240 


Glu Arg His Leu Met His Leu Glu Leu Asp Ile Ser Asp Ser Lys Ile 
                245                 250                 255     


Arg Tyr Glu Ser Gly Asp His Val Ala Val Tyr Pro Ala Asn Asp Ser 
            260                 265                 270         


Ala Leu Val Asn Gln Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp Val 
        275                 280                 285             


Val Met Ser Leu Asn Asn Leu Asp Glu Glu Ser Asn Lys Lys His Pro 
    290                 295                 300                 


Phe Pro Cys Pro Thr Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu Asp 
305                 310                 315                 320 


Ile Thr Asn Pro Pro Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln Tyr 
                325                 330                 335     


Ala Ser Glu Pro Ser Glu Gln Glu Leu Leu Arg Lys Met Ala Ser Ser 
            340                 345                 350         


Ser Gly Glu Gly Lys Glu Leu Tyr Leu Ser Trp Val Val Glu Ala Arg 
        355                 360                 365             


Arg His Ile Leu Ala Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro Pro 
    370                 375                 380                 


Ile Asp His Leu Cys Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr Tyr 
385                 390                 395                 400 


Ser Ile Ala Ser Ser Ser Lys Val His Pro Asn Ser Val His Ile Cys 
                405                 410                 415     


Ala Val Val Val Glu Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys Gly 
            420                 425                 430         


Val Ala Thr Asn Trp Leu Arg Ala Lys Glu Pro Ala Gly Glu Asn Gly 
        435                 440                 445             


Gly Arg Ala Leu Val Pro Met Phe Val Arg Lys Ser Gln Phe Arg Leu 
    450                 455                 460                 


Pro Phe Lys Ala Thr Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly 
465                 470                 475                 480 


Val Ala Pro Phe Ile Gly Phe Ile Gln Glu Arg Ala Trp Leu Arg Gln 
                485                 490                 495     


Gln Gly Lys Glu Val Gly Glu Thr Leu Leu Tyr Tyr Gly Cys Arg Arg 
            500                 505                 510         


Ser Asp Glu Asp Tyr Leu Tyr Arg Glu Glu Leu Ala Gln Phe His Arg 
        515                 520                 525             


Asp Gly Ala Leu Thr Gln Leu Asn Val Ala Phe Ser Arg Glu Gln Ser 
    530                 535                 540                 


His Lys Val Tyr Val Gln His Leu Leu Lys Gln Asp Arg Glu His Leu 
545                 550                 555                 560 


Trp Lys Leu Ile Glu Gly Gly Ala His Ile Tyr Val Cys Gly Asp Ala 
                565                 570                 575     


Arg Asn Met Ala Arg Asp Val Gln Asn Thr Phe Tyr Asp Ile Val Ala 
            580                 585                 590         


Glu Leu Gly Ala Met Glu His Ala Gln Ala Val Asp Tyr Ile Lys Lys 
        595                 600                 605             


Leu Met Thr Lys Gly Arg Tyr Ser Leu Asp Val Trp Ser 
    610                 615                 620     


<210>  3
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Ile Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Leu Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Val Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg 
                485                 490     


<210>  4
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Leu Ser Val Leu Leu Phe Leu Ala Leu Leu Thr Gly Leu Leu 
1               5                   10                  15      


Leu Leu Leu Val Gln Arg His Pro Asn Thr His Asp Arg Leu Pro Pro 
            20                  25                  30          


Gly Pro Arg Pro Leu Pro Leu Leu Gly Asn Leu Leu Gln Met Asp Arg 
        35                  40                  45              


Arg Gly Leu Leu Lys Ser Phe Leu Arg Phe Arg Glu Lys Tyr Gly Asp 
    50                  55                  60                  


Val Phe Thr Val His Leu Gly Pro Arg Pro Val Val Met Leu Cys Gly 
65                  70                  75                  80  


Val Glu Ala Ile Arg Glu Ala Leu Val Asp Lys Ala Glu Ala Phe Ser 
                85                  90                  95      


Gly Arg Gly Lys Ile Ala Met Val Asp Pro Phe Phe Arg Gly Tyr Gly 
            100                 105                 110         


Val Val Phe Ala Asn Gly Asn Arg Trp Lys Val Leu Arg Arg Phe Ser 
        115                 120                 125             


Val Thr Thr Met Arg Asp Phe Gly Met Gly Lys Arg Ser Val Glu Glu 
    130                 135                 140                 


Arg Ile Gln Glu Glu Ala Gln Cys Leu Ile Glu Glu Leu Arg Lys Ser 
145                 150                 155                 160 


Lys Gly Ala Leu Met Asp Pro Thr Phe Leu Phe Gln Ser Ile Thr Ala 
                165                 170                 175     


Asn Ile Ile Cys Ser Ile Val Phe Gly Lys Arg Phe His Tyr Gln Asp 
            180                 185                 190         


Gln Glu Phe Leu Lys Met Met Asn Leu Phe Tyr Gln Thr Phe Ser Leu 
        195                 200                 205             


Ile Ser Ser Val Phe Gly Gln Leu Phe Glu Leu Phe Ser Gly Phe Leu 
    210                 215                 220                 


Lys Tyr Phe Pro Gly Ala His Arg Gln Val Tyr Lys Asn Leu Gln Glu 
225                 230                 235                 240 


Ile Asn Ala Tyr Ile Gly His Ser Val Glu Lys His Arg Glu Thr Leu 
                245                 250                 255     


Asp Pro Ser Ala Pro Lys Asp Leu Ile Asp Thr Tyr Leu Leu His Met 
            260                 265                 270         


Glu Lys Glu Lys Ser Asn Ala His Ser Glu Phe Ser His Gln Asn Leu 
        275                 280                 285             


Asn Leu Asn Thr Leu Ser Leu Phe Phe Ala Gly Thr Glu Thr Thr Ser 
    290                 295                 300                 


Thr Thr Leu Arg Tyr Gly Phe Leu Leu Met Leu Lys Tyr Pro His Val 
305                 310                 315                 320 


Ala Glu Arg Val Tyr Arg Glu Ile Glu Gln Val Ile Gly Pro His Arg 
                325                 330                 335     


Pro Pro Glu Leu His Asp Arg Ala Lys Met Pro Tyr Thr Glu Ala Val 
            340                 345                 350         


Ile Tyr Glu Ile Gln Arg Phe Ser Asp Leu Leu Pro Met Gly Val Pro 
        355                 360                 365             


His Ile Val Thr Gln His Thr Ser Phe Arg Gly Tyr Ile Ile Pro Lys 
    370                 375                 380                 


Asp Thr Glu Val Phe Leu Ile Leu Ser Thr Ala Leu His Asp Pro His 
385                 390                 395                 400 


Tyr Phe Glu Lys Pro Asp Ala Phe Asn Pro Asp His Phe Leu Asp Ala 
                405                 410                 415     


Asn Gly Ala Leu Lys Lys Thr Glu Ala Phe Ile Pro Phe Ser Leu Gly 
            420                 425                 430         


Lys Arg Ile Cys Leu Gly Glu Gly Ile Ala Arg Ala Glu Leu Phe Leu 
        435                 440                 445             


Phe Phe Thr Thr Ile Leu Gln Asn Phe Ser Met Ala Ser Pro Val Ala 
    450                 455                 460                 


Pro Glu Asp Ile Asp Leu Thr Pro Gln Glu Cys Gly Trp Gly Lys Ile 
465                 470                 475                 480 


Pro Pro Thr Tyr Gln Ile Arg Phe Leu Pro Arg Ser Ser Ser Thr Ile 
                485                 490                 495     


Gln Thr Leu Thr Ser Ser Val Arg Glu Ser Ser Phe Val Glu Lys Met 
            500                 505                 510         


Lys Lys Thr Gly Arg Asn Ile Ile Val Phe Tyr Gly Ser Gln Thr Gly 
        515                 520                 525             


Thr Ala Glu Glu Phe Ala Asn Arg Leu Ser Lys Asp Ala His Arg Tyr 
    530                 535                 540                 


Gly Met Arg Gly Met Ser Ala Asp Pro Glu Glu Tyr Asp Leu Ala Asp 
545                 550                 555                 560 


Leu Ser Ser Leu Pro Glu Ile Asp Asn Ala Leu Val Val Phe Cys Met 
                565                 570                 575     


Ala Thr Tyr Gly Glu Gly Asp Pro Thr Asp Asn Ala Gln Asp Phe Tyr 
            580                 585                 590         


Asp Trp Leu Gln Glu Thr Asp Val Asp Leu Ser Gly Val Lys Phe Ala 
        595                 600                 605             


Val Phe Gly Leu Gly Asn Lys Thr Tyr Glu His Phe Asn Ala Met Gly 
    610                 615                 620                 


Lys Tyr Val Asp Lys Arg Leu Glu Gln Leu Gly Ala Gln Arg Ile Phe 
625                 630                 635                 640 


Glu Leu Gly Leu Gly Asp Asp Asp Gly Asn Leu Glu Glu Asp Phe Ile 
                645                 650                 655     


Thr Trp Arg Glu Gln Phe Trp Pro Ala Val Cys Glu His Phe Gly Val 
            660                 665                 670         


Glu Ala Thr Gly Glu Glu Ser Ser Ile Arg Gln Tyr Glu Leu Val Val 
        675                 680                 685             


His Thr Asp Ile Asp Ala Ala Lys Val Tyr Met Gly Glu Met Gly Arg 
    690                 695                 700                 


Leu Lys Ser Tyr Glu Asn Gln Lys Pro Pro Phe Asp Ala Lys Asn Pro 
705                 710                 715                 720 


Phe Leu Ala Ala Val Thr Thr Asn Arg Lys Leu Asn Gln Gly Thr Glu 
                725                 730                 735     


Arg His Leu Met His Leu Glu Leu Asp Ile Ser Asp Ser Lys Ile Arg 
            740                 745                 750         


Tyr Glu Ser Gly Asp His Val Ala Val Tyr Pro Ala Asn Asp Ser Ala 
        755                 760                 765             


Leu Val Asn Gln Leu Gly Lys Ile Leu Gly Ala Asp Leu Asp Val Val 
    770                 775                 780                 


Met Ser Leu Asn Asn Leu Asp Glu Glu Ser Asn Lys Lys His Pro Phe 
785                 790                 795                 800 


Pro Cys Pro Thr Ser Tyr Arg Thr Ala Leu Thr Tyr Tyr Leu Asp Ile 
                805                 810                 815     


Thr Asn Pro Pro Arg Thr Asn Val Leu Tyr Glu Leu Ala Gln Tyr Ala 
            820                 825                 830         


Ser Glu Pro Ser Glu Gln Glu Leu Leu Arg Lys Met Ala Ser Ser Ser 
        835                 840                 845             


Gly Glu Gly Lys Glu Leu Tyr Leu Ser Trp Val Val Glu Ala Arg Arg 
    850                 855                 860                 


His Ile Leu Ala Ile Leu Gln Asp Cys Pro Ser Leu Arg Pro Pro Ile 
865                 870                 875                 880 


Asp His Leu Cys Glu Leu Leu Pro Arg Leu Gln Ala Arg Tyr Tyr Ser 
                885                 890                 895     


Ile Ala Ser Ser Ser Lys Val His Pro Asn Ser Val His Ile Cys Ala 
            900                 905                 910         


Val Val Val Glu Tyr Glu Thr Lys Ala Gly Arg Ile Asn Lys Gly Val 
        915                 920                 925             


Ala Thr Asn Trp Leu Arg Ala Lys Glu Pro Ala Gly Glu Asn Gly Gly 
    930                 935                 940                 


Arg Ala Leu Val Pro Met Phe Val Arg Lys Ser Gln Phe Arg Leu Pro 
945                 950                 955                 960 


Phe Lys Ala Thr Thr Pro Val Ile Met Val Gly Pro Gly Thr Gly Val 
                965                 970                 975     


Ala Pro Phe Ile Gly Phe Ile Gln Glu Arg Ala Trp Leu Arg Gln Gln 
            980                 985                 990         


Gly Lys Glu Val Gly Glu Thr Leu  Leu Tyr Tyr Gly Cys  Arg Arg Ser 
        995                 1000                 1005             


Asp Glu  Asp Tyr Leu Tyr Arg  Glu Glu Leu Ala Gln  Phe His Arg 
    1010                 1015                 1020             


Asp Gly  Ala Leu Thr Gln Leu  Asn Val Ala Phe Ser  Arg Glu Gln 
    1025                 1030                 1035             


Ser His  Lys Val Tyr Val Gln  His Leu Leu Lys Gln  Asp Arg Glu 
    1040                 1045                 1050             


His Leu  Trp Lys Leu Ile Glu  Gly Gly Ala His Ile  Tyr Val Cys 
    1055                 1060                 1065             


Gly Asp  Ala Arg Asn Met Ala  Arg Asp Val Gln Asn  Thr Phe Tyr 
    1070                 1075                 1080             


Asp Ile  Val Ala Glu Leu Gly  Ala Met Glu His Ala  Gln Ala Val 
    1085                 1090                 1095             


Asp Tyr  Ile Lys Lys Leu Met  Thr Lys Gly Arg Tyr  Ser Leu Asp 
    1100                 1105                 1110             


Val Trp  Ser Arg Ala Glu Gly  Arg Gly Ser Leu Leu  Thr Cys Gly 
    1115                 1120                 1125             


Asp Val  Glu Glu Asn Pro Gly  Pro Met Leu Val Arg  Arg Gly Ala 
    1130                 1135                 1140             


Arg Ala  Gly Pro Arg Met Pro  Arg Gly Trp Thr Ala  Leu Cys Leu 
    1145                 1150                 1155             


Leu Ser  Leu Leu Pro Ser Gly  Phe Met Ser Leu Asp  Asn Asn Gly 
    1160                 1165                 1170             


Thr Ala  Thr Pro Glu Leu Pro  Thr Gln Gly Thr Phe  Ser Asn Val 
    1175                 1180                 1185             


Ser Thr  Asn Val Ser Tyr Gln  Glu Thr Thr Thr Pro  Ser Thr Leu 
    1190                 1195                 1200             


Gly Ser  Thr Ser Leu His Pro  Val Ser Gln His Gly  Asn Glu Ala 
    1205                 1210                 1215             


Thr Thr  Asn Ile Thr Glu Thr  Thr Val Lys Phe Thr  Ser Thr Ser 
    1220                 1225                 1230             


Val Ile  Thr Ser Val Tyr Gly  Asn Thr Asn Ser Ser  Val Gln Ser 
    1235                 1240                 1245             


Gln Thr  Ser Val Ile Ser Thr  Val Phe Thr Thr Pro  Ala Asn Val 
    1250                 1255                 1260             


Ser Thr  Pro Glu Thr Thr Leu  Lys Pro Ser Leu Ser  Pro Gly Asn 
    1265                 1270                 1275             


Val Ser  Asp Leu Ser Thr Thr  Ser Thr Ser Leu Ala  Thr Ser Pro 
    1280                 1285                 1290             


Thr Lys  Pro Tyr Thr Ser Ser  Ser Pro Ile Leu Ser  Asp Ile Lys 
    1295                 1300                 1305             


Ala Glu  Ile Lys Cys Ser Gly  Ile Arg Glu Val Lys  Leu Thr Gln 
    1310                 1315                 1320             


Gly Ile  Cys Leu Glu Gln Asn  Lys Thr Ser Ser Cys  Ala Glu Phe 
    1325                 1330                 1335             


Lys Lys  Asp Arg Gly Glu Gly  Leu Ala Arg Val Leu  Cys Gly Glu 
    1340                 1345                 1350             


Glu Gln  Ala Asp Ala Asp Ala  Gly Ala Gln Val Cys  Ser Leu Leu 
    1355                 1360                 1365             


Leu Ala  Gln Ser Glu Val Arg  Pro Gln Cys Leu Leu  Leu Val Leu 
    1370                 1375                 1380             


Ala Asn  Arg Thr Glu Ile Ser  Ser Lys Leu Gln Leu  Met Lys Lys 
    1385                 1390                 1395             


His Gln  Ser Asp Leu Lys Lys  Leu Gly Ile Leu Asp  Phe Thr Glu 
    1400                 1405                 1410             


Gln Asp  Val Ala Ser His Gln  Ser Tyr Ser Gln Lys  Thr Leu Ile 
    1415                 1420                 1425             


Ala Leu  Val Thr Ser Gly Ala  Leu Leu Ala Val Leu  Gly Ile Thr 
    1430                 1435                 1440             


Gly Tyr  Phe Leu Met Asn Arg  Arg Ser Trp Ser Pro  Thr Gly Glu 
    1445                 1450                 1455             


Arg Leu  Glu Leu Glu Pro 
    1460                 


<210>  5
<211>  987
<212>  DNA
<213>  Homo sapiens

<400>  5
atgctggtcc gcaggggcgc gcgcgcaggg cccaggatgc cgcggggctg gaccgcgctt       60

tgcttgctga gtttgctgcc ttctgggttc atgagtcttg acaacaacgg tactgctacc      120

ccagagttac ctacccaggg aacattttca aatgtttcta caaatgtatc ctaccaagaa      180

actacaacac ctagtaccct tggaagtacc agcctgcacc ctgtgtctca acatggcaat      240

gaggccacaa caaacatcac agaaacgaca gtcaaattca catctacctc tgtgataacc      300

tcagtttatg gaaacacaaa ctcttctgtc cagtcacaga cctctgtaat cagcacagtg      360

ttcaccaccc cagccaacgt ttcaactcca gagacaacct tgaagcctag cctgtcacct      420

ggaaatgttt cagacctttc aaccactagc actagccttg caacatctcc cactaaaccc      480

tatacatcat cttctcctat cctaagtgac atcaaggcag aaatcaaatg ttcaggcatc      540

agagaagtga aattgactca gggcatctgc ctggagcaaa ataagacctc cagctgtgcg      600

gagtttaaga aggacagggg agagggcctg gcccgagtgc tgtgtgggga ggagcaggct      660

gatgctgatg ctggggccca ggtatgctcc ctgctccttg cccagtctga ggtgaggcct      720

cagtgtctac tgctggtctt ggccaacaga acagaaattt ccagcaaact ccaacttatg      780

aaaaagcacc aatctgacct gaaaaagctg gggatcctag atttcactga gcaagatgtt      840

gcaagccacc agagctattc ccaaaagacc ctgattgcac tggtcacctc gggagccctg      900

ctggctgtct tgggcatcac tggctatttc ctgatgaatc gccgcagctg gagccccaca      960

ggagaaaggc tggagctgga accctga                                          987


<210>  6
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  6
agagccgagg gcaggggaag tcttctaaca tgcggggacg tggaggaaaa tcccgggccc       60


<210>  7
<211>  1047
<212>  DNA
<213>  Homo sapiens

<400>  7
agagccgagg gcaggggaag tcttctaaca tgcggggacg tggaggaaaa tcccgggccc       60

atgctggtcc gcaggggcgc gcgcgcaggg cccaggatgc cgcggggctg gaccgcgctt      120

tgcttgctga gtttgctgcc ttctgggttc atgagtcttg acaacaacgg tactgctacc      180

ccagagttac ctacccaggg aacattttca aatgtttcta caaatgtatc ctaccaagaa      240

actacaacac ctagtaccct tggaagtacc agcctgcacc ctgtgtctca acatggcaat      300

gaggccacaa caaacatcac agaaacgaca gtcaaattca catctacctc tgtgataacc      360

tcagtttatg gaaacacaaa ctcttctgtc cagtcacaga cctctgtaat cagcacagtg      420

ttcaccaccc cagccaacgt ttcaactcca gagacaacct tgaagcctag cctgtcacct      480

ggaaatgttt cagacctttc aaccactagc actagccttg caacatctcc cactaaaccc      540

tatacatcat cttctcctat cctaagtgac atcaaggcag aaatcaaatg ttcaggcatc      600

agagaagtga aattgactca gggcatctgc ctggagcaaa ataagacctc cagctgtgcg      660

gagtttaaga aggacagggg agagggcctg gcccgagtgc tgtgtgggga ggagcaggct      720

gatgctgatg ctggggccca ggtatgctcc ctgctccttg cccagtctga ggtgaggcct      780

cagtgtctac tgctggtctt ggccaacaga acagaaattt ccagcaaact ccaacttatg      840

aaaaagcacc aatctgacct gaaaaagctg gggatcctag atttcactga gcaagatgtt      900

gcaagccacc agagctattc ccaaaagacc ctgattgcac tggtcacctc gggagccctg      960

ctggctgtct tgggcatcac tggctatttc ctgatgaatc gccgcagctg gagccccaca     1020

ggagaaaggc tggagctgga accctga                                         1047


<210>  8
<211>  4395
<212>  DNA
<213>  Homo sapiens

<400>  8
atggaactca gcgtcctcct cttccttgca ctcctcacag gactcttgct actcctggtt       60

cagcgccacc ctaacaccca tgaccgcctc ccaccagggc cccgccctct gccccttttg      120

ggaaaccttc tgcagatgga tagaagaggc ctactcaaat cctttctgag gttccgagag      180

aaatatgggg acgtcttcac ggtacacctg ggaccgaggc ccgtggtcat gctgtgtgga      240

gtagaggcca tacgggaggc ccttgtggac aaggctgagg ccttctctgg ccggggaaaa      300

atcgccatgg tcgacccatt cttccgggga tatggtgtgg tctttgccaa tggaaaccgc      360

tggaaggtgc ttcggcgatt ctctgtgacc actatgaggg acttcgggat gggaaagcgg      420

agtgtggagg agcggattca ggaggaggct cagtgtctga tagaggagct tcggaaatcc      480

aagggggccc tcatggaccc caccttcctc ttccagtcca ttaccgccaa catcatctgc      540

tccatcgtct ttggaaaacg attccactac caagatcaag agttcctgaa gatgatgaac      600

ttgttctacc agactttttc actcatcagc tctgtattcg gccagctgtt tgagctcttc      660

tctggcttct tgaaatactt tcctggggca cacaggcaag tttacaaaaa cctgcaggaa      720

atcaatgctt acattggcca cagtgtggag aagcaccgtg aaaccctgga ccccagcgcc      780

cccaaggacc tcatcgacac ctacctgctc cacatggaaa aagagaaatc caacgcacac      840

agtgaattca gccaccagaa cctcaacctc aacacgctct cgctcttctt tgctggcact      900

gagaccacca gcaccactct ccgctacggc ttcctgctca tgctcaaata ccctcatgtt      960

gcagagagag tctacaggga gattgaacag gtgattggcc cacatcgccc tccagagctt     1020

catgaccgag ccaaaatgcc atacacagag gcagtcatct atgagattca gagattttcc     1080

gaccttctcc ccatgggtgt gccccacatt gtcacccaac acaccagctt ccgagggtac     1140

atcatcccca aggacacaga agtatttctc atcctgagca ctgctctcca tgacccacac     1200

tactttgaaa aaccagacgc cttcaatcct gaccactttc tggatgccaa tggggcactg     1260

aaaaagactg aagcttttat ccccttctcc ttagggaagc ggatttgtct tggtgaaggc     1320

atcgcccgtg cggaattgtt cctcttcttc accaccatcc tccagaactt ctccatggcc     1380

agccccgtgg ccccagaaga catcgatctg acaccccagg agtgtggttg gggcaaaata     1440

cccccaacat accagatccg cttcctgccc cgctcgagct ctacgattca gacattgacc     1500

tcctctgtca gagagagcag ctttgtggaa aagatgaaga aaacggggag gaacatcatc     1560

gtgttctacg gctcccagac ggggactgca gaggagtttg ccaaccgcct gtccaaggac     1620

gcccaccgct acgggatgcg aggcatgtca gcggaccctg aggagtatga cctggccgac     1680

ctgagcagcc tgccagagat cgacaacgcc ctggtggttt tctgcatggc cacctacggt     1740

gagggagacc ccaccgacaa tgcccaggac ttctacgact ggctgcagga gacagacgtg     1800

gatctctctg gggtcaagtt cgcggtgttt ggtcttggga acaagaccta cgagcacttc     1860

aatgccatgg gcaagtacgt ggacaagcgg ctggagcagc tcggcgccca gcgcatcttt     1920

gagctggggt tgggcgacga cgatgggaac ttggaggagg acttcatcac ctggcgagag     1980

cagttctggc cggccgtgtg tgaacacttt ggggtggaag ccactggcga ggagtccagc     2040

attcgccagt acgagcttgt ggtccacacc gacatagatg cggccaaggt gtacatgggg     2100

gagatgggcc ggctgaagag ctacgagaac cagaagcccc cctttgatgc caagaatccg     2160

ttcctggctg cagtcaccac caaccggaag ctgaaccagg gaaccgagcg ccacctcatg     2220

cacctggaat tggacatctc ggactccaaa atcaggtatg aatctgggga ccacgtggct     2280

gtgtacccag ccaacgactc tgctctcgtc aaccagctgg gcaaaatcct gggtgccgac     2340

ctggacgtcg tcatgtccct gaacaacctg gatgaggagt ccaacaagaa gcacccattc     2400

ccgtgcccta cgtcctaccg cacggccctc acctactacc tggacatcac caacccgccg     2460

cgtaccaacg tgctgtacga gctggcgcag tacgcctcgg agccctcgga gcaggagctg     2520

ctgcgcaaga tggcctcctc ctccggcgag ggcaaggagc tgtacctgag ctgggtggtg     2580

gaggcccgga ggcacatcct ggccatcctg caggactgcc cgtccctgcg gccccccatc     2640

gaccacctgt gtgagctgct gccgcgcctg caggcccgct actactccat cgcctcatcc     2700

tccaaggtcc accccaactc tgtgcacatc tgtgcggtgg ttgtggagta cgagaccaag     2760

gccggccgca tcaacaaggg cgtggccacc aactggctgc gggccaagga gcctgccggg     2820

gagaacggcg gccgtgcgct ggtgcccatg ttcgtgcgca agtcccagtt ccgcctgccc     2880

ttcaaggcca ccacgcctgt catcatggtg ggccccggca ccggggtggc acccttcata     2940

ggcttcatcc aggagcgggc ctggctgcga cagcagggca aggaggtggg ggagacgctg     3000

ctgtactacg gctgccgccg ctcggatgag gactacctgt accgggagga gctggcgcag     3060

ttccacaggg acggtgcgct cacccagctc aacgtggcct tctcccggga gcagtcccac     3120

aaggtctacg tccagcacct gctaaagcaa gaccgagagc acctgtggaa gttgatcgaa     3180

ggcggtgccc acatctacgt ctgtggggat gcacggaaca tggccaggga tgtgcagaac     3240

accttctacg acatcgtggc tgagctcggg gccatggagc acgcgcaggc ggtggactac     3300

atcaagaaac tgatgaccaa gggccgctac tccctggacg tgtggagcag agccgagggc     3360

aggggaagtc ttctaacatg cggggacgtg gaggaaaatc ccgggcccat gctggtccgc     3420

aggggcgcgc gcgcagggcc caggatgccg cggggctgga ccgcgctttg cttgctgagt     3480

ttgctgcctt ctgggttcat gagtcttgac aacaacggta ctgctacccc agagttacct     3540

acccagggaa cattttcaaa tgtttctaca aatgtatcct accaagaaac tacaacacct     3600

agtacccttg gaagtaccag cctgcaccct gtgtctcaac atggcaatga ggccacaaca     3660

aacatcacag aaacgacagt caaattcaca tctacctctg tgataacctc agtttatgga     3720

aacacaaact cttctgtcca gtcacagacc tctgtaatca gcacagtgtt caccacccca     3780

gccaacgttt caactccaga gacaaccttg aagcctagcc tgtcacctgg aaatgtttca     3840

gacctttcaa ccactagcac tagccttgca acatctccca ctaaacccta tacatcatct     3900

tctcctatcc taagtgacat caaggcagaa atcaaatgtt caggcatcag agaagtgaaa     3960

ttgactcagg gcatctgcct ggagcaaaat aagacctcca gctgtgcgga gtttaagaag     4020

gacaggggag agggcctggc ccgagtgctg tgtggggagg agcaggctga tgctgatgct     4080

ggggcccagg tatgctccct gctccttgcc cagtctgagg tgaggcctca gtgtctactg     4140

ctggtcttgg ccaacagaac agaaatttcc agcaaactcc aacttatgaa aaagcaccaa     4200

tctgacctga aaaagctggg gatcctagat ttcactgagc aagatgttgc aagccaccag     4260

agctattccc aaaagaccct gattgcactg gtcacctcgg gagccctgct ggctgtcttg     4320

ggcatcactg gctatttcct gatgaatcgc cgcagctgga gccccacagg agaaaggctg     4380

gagctggaac cctga                                                      4395


