                         SEQUENCE LISTING

<110>  Amicus Therapeutics, Inc.
 
<120>  VARIANT IGF2 CONSTRUCTS

<130>  AT19-009-PCT

<160>  250   

<170>  PatentIn version 3.5

<210>  1
<211>  952
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Natural hGAA

<400>  1

Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  2
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Engineered hGAA (BiP-vIGF2-GAA)

<400>  2

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln 
            20                  25                  30          


Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg 
        35                  40                  45              


Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser 
    50                  55                  60                  


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser 
65                  70                  75                  80  


Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Gly Pro Arg 
                85                  90                  95      


Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys 
            100                 105                 110         


Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile 
        115                 120                 125             


Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys 
    130                 135                 140                 


Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro 
145                 150                 155                 160 


Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met 
                165                 170                 175     


Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys 
            180                 185                 190         


Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg 
        195                 200                 205             


Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro 
    210                 215                 220                 


Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser 
225                 230                 235                 240 


Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu 
                245                 250                 255     


Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala 
            260                 265                 270         


Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr 
        275                 280                 285             


Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr 
    290                 295                 300                 


Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn 
305                 310                 315                 320 


Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser 
                325                 330                 335     


Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu 
            340                 345                 350         


Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp 
        355                 360                 365             


Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr 
    370                 375                 380                 


Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly 
385                 390                 395                 400 


Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln 
                405                 410                 415     


Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp 
            420                 425                 430         


Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys 
        435                 440                 445             


Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly 
    450                 455                 460                 


Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly 
465                 470                 475                 480 


Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val 
                485                 490                 495     


Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro 
            500                 505                 510         


Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp 
        515                 520                 525             


Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly 
    530                 535                 540                 


Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu 
545                 550                 555                 560 


Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly 
                565                 570                 575     


Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His 
            580                 585                 590         


Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr 
        595                 600                 605             


Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg 
    610                 615                 620                 


Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala 
625                 630                 635                 640 


Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser 
                645                 650                 655     


Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val 
            660                 665                 670         


Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys 
        675                 680                 685             


Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His 
    690                 695                 700                 


Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro 
705                 710                 715                 720 


Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu 
                725                 730                 735     


Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr 
            740                 745                 750         


Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp 
        755                 760                 765             


Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro 
    770                 775                 780                 


Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly 
785                 790                 795                 800 


Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu 
                805                 810                 815     


Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly 
            820                 825                 830         


Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu 
        835                 840                 845             


Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr 
    850                 855                 860                 


Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly 
865                 870                 875                 880 


Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu 
                885                 890                 895     


Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn 
            900                 905                 910         


Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly 
        915                 920                 925             


Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln 
    930                 935                 940                 


Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro 
945                 950                 955                 960 


Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln 
                965                 970                 975     


Phe Leu Val Ser Trp Cys 
            980         


<210>  3
<211>  892
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hGAA delta 1-60

<400>  3

Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg 
1               5                   10                  15      


Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys 
            20                  25                  30          


Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys 
        35                  40                  45              


Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln 
    50                  55                  60                  


Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn 
65                  70                  75                  80  


Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr 
                85                  90                  95      


Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met 
            100                 105                 110         


Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn 
        115                 120                 125             


Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala 
    130                 135                 140                 


Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val 
145                 150                 155                 160 


Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val 
                165                 170                 175     


Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu 
            180                 185                 190         


Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met 
        195                 200                 205             


Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala 
    210                 215                 220                 


Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala 
225                 230                 235                 240 


Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn 
                245                 250                 255     


Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser 
            260                 265                 270         


Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys 
        275                 280                 285             


Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro 
    290                 295                 300                 


Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser 
305                 310                 315                 320 


Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe 
                325                 330                 335     


Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg 
            340                 345                 350         


Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val 
        355                 360                 365             


Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro 
    370                 375                 380                 


Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu 
385                 390                 395                 400 


Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu 
                405                 410                 415     


Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn 
            420                 425                 430         


Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp 
        435                 440                 445             


Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn 
    450                 455                 460                 


Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn 
465                 470                 475                 480 


Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr 
                485                 490                 495     


Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His 
            500                 505                 510         


Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val 
        515                 520                 525             


Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala 
    530                 535                 540                 


Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser 
545                 550                 555                 560 


Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu 
                565                 570                 575     


Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn 
            580                 585                 590         


Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr 
        595                 600                 605             


Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro 
    610                 615                 620                 


Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr 
625                 630                 635                 640 


Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala 
                645                 650                 655     


His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro 
            660                 665                 670         


Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu 
        675                 680                 685             


Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr 
    690                 695                 700                 


Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val 
705                 710                 715                 720 


Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro 
                725                 730                 735     


Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp 
            740                 745                 750         


Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly 
        755                 760                 765             


Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala 
    770                 775                 780                 


Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp 
785                 790                 795                 800 


Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val 
                805                 810                 815     


Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val 
            820                 825                 830         


Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly 
        835                 840                 845             


Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser 
    850                 855                 860                 


Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser 
865                 870                 875                 880 


Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
                885                 890         


<210>  4
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wt-PPT1

<400>  4

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  5
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-2 (vIGF2-PPT1)

<400>  5

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Ser Arg Thr Leu Cys 
            20                  25                  30          


Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly 
        35                  40                  45              


Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly 
    50                  55                  60                  


Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu 
65                  70                  75                  80  


Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Asp Pro Pro Ala 
            100                 105                 110         


Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn 
        115                 120                 125             


Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro 
    130                 135                 140                 


Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp 
145                 150                 155                 160 


Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val 
                165                 170                 175     


Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala 
            180                 185                 190         


Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg 
        195                 200                 205             


Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His 
    210                 215                 220                 


Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile 
225                 230                 235                 240 


Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val 
                245                 250                 255     


Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys 
            260                 265                 270         


Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln 
        275                 280                 285             


Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys 
    290                 295                 300                 


Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val 
305                 310                 315                 320 


Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr 
                325                 330                 335     


Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu 
            340                 345                 350         


Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly 
        355                 360                 365             


Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro 
    370                 375                 380                 


Phe Leu Gly 
385         


<210>  6
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-29 (BiP2aa-vIGF2-PPT1)

<400>  6

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Trp Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Arg Ala Ala Ala Ser Arg Thr Leu Cys 
            20                  25                  30          


Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly 
        35                  40                  45              


Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly 
    50                  55                  60                  


Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu 
65                  70                  75                  80  


Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Asp Pro Pro Ala 
            100                 105                 110         


Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn 
        115                 120                 125             


Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro 
    130                 135                 140                 


Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp 
145                 150                 155                 160 


Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val 
                165                 170                 175     


Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala 
            180                 185                 190         


Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg 
        195                 200                 205             


Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His 
    210                 215                 220                 


Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile 
225                 230                 235                 240 


Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val 
                245                 250                 255     


Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys 
            260                 265                 270         


Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln 
        275                 280                 285             


Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys 
    290                 295                 300                 


Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val 
305                 310                 315                 320 


Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr 
                325                 330                 335     


Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu 
            340                 345                 350         


Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly 
        355                 360                 365             


Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro 
    370                 375                 380                 


Phe Leu Gly 
385         


<210>  7
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1 engineered

<400>  7

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Thr Ser Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                325                 330                 335     


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala 
            340                 345                 350         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        355                 360                 365             


Arg Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    370                 375                 380                 


Arg Ser Glu 
385         


<210>  8
<211>  563
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP1 wildtype

<400>  8

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro 
            20                  25                  30          


Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser 
        35                  40                  45              


Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu 
    50                  55                  60                  


Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu 
65                  70                  75                  80  


Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu 
                85                  90                  95      


His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His 
            100                 105                 110         


Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln 
        115                 120                 125             


Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly 
    130                 135                 140                 


Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro 
145                 150                 155                 160 


Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe 
                165                 170                 175     


Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly 
            180                 185                 190         


Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg 
        195                 200                 205             


Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser 
    210                 215                 220                 


Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu 
225                 230                 235                 240 


Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser 
                245                 250                 255     


Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu 
            260                 265                 270         


Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser 
        275                 280                 285             


Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe 
    290                 295                 300                 


Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val 
305                 310                 315                 320 


His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr 
                325                 330                 335     


Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu 
            340                 345                 350         


Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val 
        355                 360                 365             


Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr 
    370                 375                 380                 


Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr 
385                 390                 395                 400 


Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe 
                405                 410                 415     


Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser 
            420                 425                 430         


Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala 
        435                 440                 445             


Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn 
    450                 455                 460                 


Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val 
465                 470                 475                 480 


Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly 
                485                 490                 495     


Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly 
            500                 505                 510         


Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp 
        515                 520                 525             


Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro 
    530                 535                 540                 


Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu 
545                 550                 555                 560 


Leu Asn Pro 
            


<210>  9
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP1 engineered

<400>  9

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser 
        35                  40                  45              


Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg 
    50                  55                  60                  


Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg 
65                  70                  75                  80  


Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala 
                85                  90                  95      


Val Pro Thr Gln Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu 
            100                 105                 110         


Pro Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu 
        115                 120                 125             


Ser Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu 
    130                 135                 140                 


Leu Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr 
145                 150                 155                 160 


Leu Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr 
                165                 170                 175     


Leu His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys 
            180                 185                 190         


His Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg 
        195                 200                 205             


Gln Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly 
    210                 215                 220                 


Gly Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu 
225                 230                 235                 240 


Pro Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg 
                245                 250                 255     


Phe Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr 
            260                 265                 270         


Gly Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys 
        275                 280                 285             


Arg Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn 
    290                 295                 300                 


Ser Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp 
305                 310                 315                 320 


Leu Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala 
                325                 330                 335     


Ser Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile 
            340                 345                 350         


Glu Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile 
        355                 360                 365             


Ser Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro 
    370                 375                 380                 


Phe Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His 
385                 390                 395                 400 


Val His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala 
                405                 410                 415     


Tyr Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly 
            420                 425                 430         


Leu Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser 
        435                 440                 445             


Val Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro 
    450                 455                 460                 


Tyr Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile 
465                 470                 475                 480 


Thr Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val 
                485                 490                 495     


Phe Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser 
            500                 505                 510         


Ser Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg 
        515                 520                 525             


Ala Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser 
    530                 535                 540                 


Asn Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro 
545                 550                 555                 560 


Val Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser 
                565                 570                 575     


Gly Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His 
            580                 585                 590         


Gly Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu 
        595                 600                 605             


Asp Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp 
    610                 615                 620                 


Pro Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr 
625                 630                 635                 640 


Leu Leu Asn Pro 
                


<210>  10
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGA wildtype

<400>  10

Met Ala Arg Lys Ser Asn Leu Pro Val Leu Leu Val Pro Phe Leu Leu 
1               5                   10                  15      


Cys Gln Ala Leu Val Arg Cys Ser Ser Pro Leu Pro Leu Val Val Asn 
            20                  25                  30          


Thr Trp Pro Phe Lys Asn Ala Thr Glu Ala Ala Trp Arg Ala Leu Ala 
        35                  40                  45              


Ser Gly Gly Ser Ala Leu Asp Ala Val Glu Ser Gly Cys Ala Met Cys 
    50                  55                  60                  


Glu Arg Glu Gln Cys Asp Gly Ser Val Gly Phe Gly Gly Ser Pro Asp 
65                  70                  75                  80  


Glu Leu Gly Glu Thr Thr Leu Asp Ala Met Ile Met Asp Gly Thr Thr 
                85                  90                  95      


Met Asp Val Gly Ala Val Gly Asp Leu Arg Arg Ile Lys Asn Ala Ile 
            100                 105                 110         


Gly Val Ala Arg Lys Val Leu Glu His Thr Thr His Thr Leu Leu Val 
        115                 120                 125             


Gly Glu Ser Ala Thr Thr Phe Ala Gln Ser Met Gly Phe Ile Asn Glu 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ala Ser Gln Ala Leu His Ser Asp Trp Leu Ala 
145                 150                 155                 160 


Arg Asn Cys Gln Pro Asn Tyr Trp Arg Asn Val Ile Pro Asp Pro Ser 
                165                 170                 175     


Lys Tyr Cys Gly Pro Tyr Lys Pro Pro Gly Ile Leu Lys Gln Asp Ile 
            180                 185                 190         


Pro Ile His Lys Glu Thr Glu Asp Asp Arg Gly His Asp Thr Ile Gly 
        195                 200                 205             


Met Val Val Ile His Lys Thr Gly His Ile Ala Ala Gly Thr Ser Thr 
    210                 215                 220                 


Asn Gly Ile Lys Phe Lys Ile His Gly Arg Val Gly Asp Ser Pro Ile 
225                 230                 235                 240 


Pro Gly Ala Gly Ala Tyr Ala Asp Asp Thr Ala Gly Ala Ala Ala Ala 
                245                 250                 255     


Thr Gly Asn Gly Asp Ile Leu Met Arg Phe Leu Pro Ser Tyr Gln Ala 
            260                 265                 270         


Val Glu Tyr Met Arg Arg Gly Glu Asp Pro Thr Ile Ala Cys Gln Lys 
        275                 280                 285             


Val Ile Ser Arg Ile Gln Lys His Phe Pro Glu Phe Phe Gly Ala Val 
    290                 295                 300                 


Ile Cys Ala Asn Val Thr Gly Ser Tyr Gly Ala Ala Cys Asn Lys Leu 
305                 310                 315                 320 


Ser Thr Phe Thr Gln Phe Ser Phe Met Val Tyr Asn Ser Glu Lys Asn 
                325                 330                 335     


Gln Pro Thr Glu Glu Lys Val Asp Cys Ile 
            340                 345     


<210>  11
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AGA engineered (N-terminal fusion)

<400>  11

Met Ala Arg Lys Ser Asn Leu Pro Val Leu Leu Val Pro Phe Leu Leu 
1               5                   10                  15      


Cys Gln Ala Leu Val Arg Cys Ser Arg Thr Leu Cys Gly Gly Glu Leu 
            20                  25                  30          


Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser 
        35                  40                  45              


Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu 
    50                  55                  60                  


Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala 
65                  70                  75                  80  


Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90                  95      


Arg Pro Arg Ala Val Pro Thr Gln Ser Ser Pro Leu Pro Leu Val Val 
            100                 105                 110         


Asn Thr Trp Pro Phe Lys Asn Ala Thr Glu Ala Ala Trp Arg Ala Leu 
        115                 120                 125             


Ala Ser Gly Gly Ser Ala Leu Asp Ala Val Glu Ser Gly Cys Ala Met 
    130                 135                 140                 


Cys Glu Arg Glu Gln Cys Asp Gly Ser Val Gly Phe Gly Gly Ser Pro 
145                 150                 155                 160 


Asp Glu Leu Gly Glu Thr Thr Leu Asp Ala Met Ile Met Asp Gly Thr 
                165                 170                 175     


Thr Met Asp Val Gly Ala Val Gly Asp Leu Arg Arg Ile Lys Asn Ala 
            180                 185                 190         


Ile Gly Val Ala Arg Lys Val Leu Glu His Thr Thr His Thr Leu Leu 
        195                 200                 205             


Val Gly Glu Ser Ala Thr Thr Phe Ala Gln Ser Met Gly Phe Ile Asn 
    210                 215                 220                 


Glu Asp Leu Ser Thr Thr Ala Ser Gln Ala Leu His Ser Asp Trp Leu 
225                 230                 235                 240 


Ala Arg Asn Cys Gln Pro Asn Tyr Trp Arg Asn Val Ile Pro Asp Pro 
                245                 250                 255     


Ser Lys Tyr Cys Gly Pro Tyr Lys Pro Pro Gly Ile Leu Lys Gln Asp 
            260                 265                 270         


Ile Pro Ile His Lys Glu Thr Glu Asp Asp Arg Gly His Asp Thr Ile 
        275                 280                 285             


Gly Met Val Val Ile His Lys Thr Gly His Ile Ala Ala Gly Thr Ser 
    290                 295                 300                 


Thr Asn Gly Ile Lys Phe Lys Ile His Gly Arg Val Gly Asp Ser Pro 
305                 310                 315                 320 


Ile Pro Gly Ala Gly Ala Tyr Ala Asp Asp Thr Ala Gly Ala Ala Ala 
                325                 330                 335     


Ala Thr Gly Asn Gly Asp Ile Leu Met Arg Phe Leu Pro Ser Tyr Gln 
            340                 345                 350         


Ala Val Glu Tyr Met Arg Arg Gly Glu Asp Pro Thr Ile Ala Cys Gln 
        355                 360                 365             


Lys Val Ile Ser Arg Ile Gln Lys His Phe Pro Glu Phe Phe Gly Ala 
    370                 375                 380                 


Val Ile Cys Ala Asn Val Thr Gly Ser Tyr Gly Ala Ala Cys Asn Lys 
385                 390                 395                 400 


Leu Ser Thr Phe Thr Gln Phe Ser Phe Met Val Tyr Asn Ser Glu Lys 
                405                 410                 415     


Asn Gln Pro Thr Glu Glu Lys Val Asp Cys Ile 
            420                 425         


<210>  12
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLA wildtype

<400>  12

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
            420                 425                 


<210>  13
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLA engineered

<400>  13

Met Gln Leu Arg Asn Pro Glu Leu His Leu Gly Cys Ala Leu Ala Leu 
1               5                   10                  15      


Arg Phe Leu Ala Leu Val Ser Trp Asp Ile Pro Gly Ala Arg Ala Leu 
            20                  25                  30          


Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp Glu 
        35                  40                  45              


Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys Ile 
    50                  55                  60                  


Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu Gly 
65                  70                  75                  80  


Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp Met 
                85                  90                  95      


Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln Arg 
            100                 105                 110         


Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys Gly 
        115                 120                 125             


Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala Gly 
    130                 135                 140                 


Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe Ala 
145                 150                 155                 160 


Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp Ser 
                165                 170                 175     


Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu Asn 
            180                 185                 190         


Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr Met 
        195                 200                 205             


Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys Asn 
    210                 215                 220                 


His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile Lys 
225                 230                 235                 240 


Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp Val 
                245                 250                 255     


Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly Asn 
            260                 265                 270         


Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp Ala 
        275                 280                 285             


Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile Ser 
    290                 295                 300                 


Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile Asn 
305                 310                 315                 320 


Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp Asn 
                325                 330                 335     


Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val Ala 
            340                 345                 350         


Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile Ala 
        355                 360                 365             


Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe Ile 
    370                 375                 380                 


Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp Thr 
385                 390                 395                 400 


Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu Gln 
                405                 410                 415     


Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu Tyr Ile Pro 
            420                 425                 430         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Arg Thr Leu Cys Gly Gly Glu Leu Val 
    450                 455                 460                 


Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg 
465                 470                 475                 480 


Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys 
                485                 490                 495     


Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr 
            500                 505                 510         


Pro Ala Arg Ser Glu 
        515         


<210>  14
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BiP-vIGF2-17-2GS-GAA

<400>  14

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln 
            20                  25                  30          


Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg 
        35                  40                  45              


Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Glu 
    50                  55                  60                  


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser 
65                  70                  75                  80  


Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Gly Pro Arg 
                85                  90                  95      


Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys 
            100                 105                 110         


Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile 
        115                 120                 125             


Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys 
    130                 135                 140                 


Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro 
145                 150                 155                 160 


Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met 
                165                 170                 175     


Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys 
            180                 185                 190         


Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg 
        195                 200                 205             


Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro 
    210                 215                 220                 


Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser 
225                 230                 235                 240 


Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu 
                245                 250                 255     


Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala 
            260                 265                 270         


Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr 
        275                 280                 285             


Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr 
    290                 295                 300                 


Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn 
305                 310                 315                 320 


Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser 
                325                 330                 335     


Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu 
            340                 345                 350         


Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp 
        355                 360                 365             


Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr 
    370                 375                 380                 


Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly 
385                 390                 395                 400 


Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln 
                405                 410                 415     


Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp 
            420                 425                 430         


Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys 
        435                 440                 445             


Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly 
    450                 455                 460                 


Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly 
465                 470                 475                 480 


Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val 
                485                 490                 495     


Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro 
            500                 505                 510         


Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp 
        515                 520                 525             


Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly 
    530                 535                 540                 


Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu 
545                 550                 555                 560 


Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly 
                565                 570                 575     


Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His 
            580                 585                 590         


Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr 
        595                 600                 605             


Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg 
    610                 615                 620                 


Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala 
625                 630                 635                 640 


Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser 
                645                 650                 655     


Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val 
            660                 665                 670         


Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys 
        675                 680                 685             


Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His 
    690                 695                 700                 


Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro 
705                 710                 715                 720 


Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu 
                725                 730                 735     


Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr 
            740                 745                 750         


Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp 
        755                 760                 765             


Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro 
    770                 775                 780                 


Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly 
785                 790                 795                 800 


Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu 
                805                 810                 815     


Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly 
            820                 825                 830         


Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu 
        835                 840                 845             


Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr 
    850                 855                 860                 


Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly 
865                 870                 875                 880 


Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu 
                885                 890                 895     


Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn 
            900                 905                 910         


Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly 
        915                 920                 925             


Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln 
    930                 935                 940                 


Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro 
945                 950                 955                 960 


Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln 
                965                 970                 975     


Phe Leu Val Ser Trp Cys 
            980         


<210>  15
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BiP-vIGF2-20-2GS-GAA

<400>  15

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln 
            20                  25                  30          


Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg 
        35                  40                  45              


Val Ser Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Ser 
    50                  55                  60                  


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser 
65                  70                  75                  80  


Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Gly Pro Arg 
                85                  90                  95      


Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys 
            100                 105                 110         


Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile 
        115                 120                 125             


Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys 
    130                 135                 140                 


Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro 
145                 150                 155                 160 


Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met 
                165                 170                 175     


Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys 
            180                 185                 190         


Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg 
        195                 200                 205             


Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro 
    210                 215                 220                 


Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser 
225                 230                 235                 240 


Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu 
                245                 250                 255     


Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala 
            260                 265                 270         


Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr 
        275                 280                 285             


Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr 
    290                 295                 300                 


Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn 
305                 310                 315                 320 


Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser 
                325                 330                 335     


Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu 
            340                 345                 350         


Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp 
        355                 360                 365             


Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr 
    370                 375                 380                 


Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly 
385                 390                 395                 400 


Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln 
                405                 410                 415     


Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp 
            420                 425                 430         


Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys 
        435                 440                 445             


Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly 
    450                 455                 460                 


Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly 
465                 470                 475                 480 


Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val 
                485                 490                 495     


Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro 
            500                 505                 510         


Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp 
        515                 520                 525             


Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly 
    530                 535                 540                 


Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu 
545                 550                 555                 560 


Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly 
                565                 570                 575     


Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His 
            580                 585                 590         


Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr 
        595                 600                 605             


Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg 
    610                 615                 620                 


Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala 
625                 630                 635                 640 


Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser 
                645                 650                 655     


Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val 
            660                 665                 670         


Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys 
        675                 680                 685             


Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His 
    690                 695                 700                 


Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro 
705                 710                 715                 720 


Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu 
                725                 730                 735     


Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr 
            740                 745                 750         


Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp 
        755                 760                 765             


Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro 
    770                 775                 780                 


Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly 
785                 790                 795                 800 


Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu 
                805                 810                 815     


Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly 
            820                 825                 830         


Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu 
        835                 840                 845             


Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr 
    850                 855                 860                 


Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly 
865                 870                 875                 880 


Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu 
                885                 890                 895     


Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn 
            900                 905                 910         


Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly 
        915                 920                 925             


Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln 
    930                 935                 940                 


Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro 
945                 950                 955                 960 


Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln 
                965                 970                 975     


Phe Leu Val Ser Trp Cys 
            980         


<210>  16
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BiP-vIGF2-22-2GS-GAA

<400>  16

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln 
            20                  25                  30          


Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly Gly 
        35                  40                  45              


Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala 
    50                  55                  60                  


Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala 
                85                  90                  95      


His Pro Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro 
            100                 105                 110         


Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln 
        115                 120                 125             


Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln 
    130                 135                 140                 


Gly Ala Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro 
145                 150                 155                 160 


Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala 
                165                 170                 175     


Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr 
            180                 185                 190         


Leu Arg Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr 
        195                 200                 205             


Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro 
    210                 215                 220                 


His Val His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser 
225                 230                 235                 240 


Glu Glu Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val 
                245                 250                 255     


Leu Leu Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu 
            260                 265                 270         


Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu 
        275                 280                 285             


His Leu Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu 
    290                 295                 300                 


Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser 
305                 310                 315                 320 


His Pro Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val 
                325                 330                 335     


Phe Leu Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro 
            340                 345                 350         


Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe 
        355                 360                 365             


Leu Gly Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val 
    370                 375                 380                 


Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys 
385                 390                 395                 400 


Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn 
                405                 410                 415     


Met Thr Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp 
            420                 425                 430         


Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg 
        435                 440                 445             


Asp Phe Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr 
    450                 455                 460                 


Met Met Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser 
465                 470                 475                 480 


Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn 
                485                 490                 495     


Glu Thr Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala 
            500                 505                 510         


Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met 
        515                 520                 525             


Val Ala Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp 
    530                 535                 540                 


Met Asn Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro 
545                 550                 555                 560 


Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly 
                565                 570                 575     


Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser 
            580                 585                 590         


Thr His Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala 
        595                 600                 605             


Ser His Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile 
    610                 615                 620                 


Ser Arg Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr 
625                 630                 635                 640 


Gly Asp Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu 
                645                 650                 655     


Ile Leu Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val 
            660                 665                 670         


Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr 
        675                 680                 685             


Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu 
    690                 695                 700                 


Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala 
705                 710                 715                 720 


Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr 
                725                 730                 735     


Thr Leu Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro 
            740                 745                 750         


Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His 
        755                 760                 765             


Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala 
    770                 775                 780                 


Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp 
785                 790                 795                 800 


Leu Gln Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro 
                805                 810                 815     


Ala Ala Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr 
            820                 825                 830         


Leu Pro Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr 
        835                 840                 845             


Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln 
    850                 855                 860                 


Gln Pro Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg 
865                 870                 875                 880 


Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg 
                885                 890                 895     


Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val 
            900                 905                 910         


Asn Glu Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln 
        915                 920                 925             


Lys Val Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser 
    930                 935                 940                 


Asn Gly Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val 
945                 950                 955                 960 


Leu Asp Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser 
                965                 970                 975     


Trp Cys 
        


<210>  17
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-3 (BiP-PPT1)

<400>  17

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His Gly Met 
            20                  25                  30          


Gly Asp Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met 
        35                  40                  45              


Val Glu Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly 
    50                  55                  60                  


Lys Thr Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn 
65                  70                  75                  80  


Ser Gln Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu 
                85                  90                  95      


Gln Gln Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu 
            100                 105                 110         


Arg Ala Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile 
        115                 120                 125             


Ser Val Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro 
    130                 135                 140                 


Gly Glu Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala 
145                 150                 155                 160 


Gly Ala Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr 
                165                 170                 175     


Trp His Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe 
            180                 185                 190         


Leu Ala Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys 
        195                 200                 205             


Asn Leu Met Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp 
    210                 215                 220                 


Ser Ile Val Asp Pro Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser 
225                 230                 235                 240 


Gly Gln Ala Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr 
                245                 250                 255     


Gln Asp Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val 
            260                 265                 270         


Phe Leu Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe 
        275                 280                 285             


Tyr Ala His Ile Ile Pro Phe Leu Gly 
    290                 295         


<210>  18
<211>  378
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-4 (BiP-vIGF2-PPT1)

<400>  18

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln 
            20                  25                  30          


Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg 
        35                  40                  45              


Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser 
    50                  55                  60                  


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser 
65                  70                  75                  80  


Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala Val 
                85                  90                  95      


Pro Thr Gln Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His Gly 
            100                 105                 110         


Met Gly Asp Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys Lys 
        115                 120                 125             


Met Val Glu Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile 
    130                 135                 140                 


Gly Lys Thr Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn Val 
145                 150                 155                 160 


Asn Ser Gln Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro Lys 
                165                 170                 175     


Leu Gln Gln Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln Phe 
            180                 185                 190         


Leu Arg Ala Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn Leu 
        195                 200                 205             


Ile Ser Val Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg Cys 
    210                 215                 220                 


Pro Gly Glu Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn 
225                 230                 235                 240 


Ala Gly Ala Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala Glu 
                245                 250                 255     


Tyr Trp His Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser Ile 
            260                 265                 270         


Phe Leu Ala Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys 
        275                 280                 285             


Lys Asn Leu Met Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu Asn 
    290                 295                 300                 


Asp Ser Ile Val Asp Pro Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg 
305                 310                 315                 320 


Ser Gly Gln Ala Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr 
                325                 330                 335     


Thr Gln Asp Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln Leu 
            340                 345                 350         


Val Phe Leu Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu Trp 
        355                 360                 365             


Phe Tyr Ala His Ile Ile Pro Phe Leu Gly 
    370                 375             


<210>  19
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-5 (wt-PPT1-vIGF2)

<400>  19

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
                325                 330                 335     


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser 
            340                 345                 350         


Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg 
        355                 360                 365             


Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg 
    370                 375                 380                 


Ser Glu 
385     


<210>  20
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-9 (wt-PPT1)

<400>  20

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  21
<211>  386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-10 (wt-PPT1-vIGF2_2)

<400>  21

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Thr Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
                325                 330                 335     


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser 
            340                 345                 350         


Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg 
        355                 360                 365             


Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg 
    370                 375                 380                 


Ser Glu 
385     


<210>  22
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-11 (BiP-PPT1_2)

<400>  22

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro Leu Pro 
            20                  25                  30          


Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro Leu Ser 
        35                  40                  45              


Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly Ile Tyr 
    50                  55                  60                  


Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val Glu Asn 
65                  70                  75                  80  


Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys Gln Ala 
                85                  90                  95      


Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met Gly Phe 
            100                 105                 110         


Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys Pro Ser 
        115                 120                 125             


Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln Gly Val 
    130                 135                 140                 


Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys Asp Phe 
145                 150                 155                 160 


Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val Gln Glu 
                165                 170                 175     


Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu Asp Val 
            180                 185                 190         


Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg Gly 
        195                 200                 205             


Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys Phe Val 
    210                 215                 220                 


Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp Ser Glu 
225                 230                 235                 240 


Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile Pro Leu 
                245                 250                 255     


Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys Glu Met 
            260                 265                 270         


Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp His Leu 
        275                 280                 285             


Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe Leu Gly 
    290                 295                 300                 


<210>  23
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-12 (BiPaa-PPT1_2)

<400>  23

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro Leu Pro 
            20                  25                  30          


Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro Leu Ser 
        35                  40                  45              


Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly Ile Tyr 
    50                  55                  60                  


Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val Glu Asn 
65                  70                  75                  80  


Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys Gln Ala 
                85                  90                  95      


Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met Gly Phe 
            100                 105                 110         


Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys Pro Ser 
        115                 120                 125             


Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln Gly Val 
    130                 135                 140                 


Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys Asp Phe 
145                 150                 155                 160 


Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val Gln Glu 
                165                 170                 175     


Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu Asp Val 
            180                 185                 190         


Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg Gly 
        195                 200                 205             


Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys Phe Val 
    210                 215                 220                 


Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp Ser Glu 
225                 230                 235                 240 


Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile Pro Leu 
                245                 250                 255     


Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys Glu Met 
            260                 265                 270         


Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp His Leu 
        275                 280                 285             


Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe Leu Gly 
    290                 295                 300                 


<210>  24
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-13 (BiPaa-PPT1)

<400>  24

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Ala Ala Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His 
            20                  25                  30          


Gly Met Gly Asp Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys 
        35                  40                  45              


Lys Met Val Glu Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu 
    50                  55                  60                  


Ile Gly Lys Thr Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn 
65                  70                  75                  80  


Val Asn Ser Gln Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro 
                85                  90                  95      


Lys Leu Gln Gln Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln 
            100                 105                 110         


Phe Leu Arg Ala Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn 
        115                 120                 125             


Leu Ile Ser Val Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg 
    130                 135                 140                 


Cys Pro Gly Glu Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu 
145                 150                 155                 160 


Asn Ala Gly Ala Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala 
                165                 170                 175     


Glu Tyr Trp His Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser 
            180                 185                 190         


Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr 
        195                 200                 205             


Lys Lys Asn Leu Met Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu 
    210                 215                 220                 


Asn Asp Ser Ile Val Asp Pro Val Asp Ser Glu Trp Phe Gly Phe Tyr 
225                 230                 235                 240 


Arg Ser Gly Gln Ala Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser Leu 
                245                 250                 255     


Tyr Thr Gln Asp Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln 
            260                 265                 270         


Leu Val Phe Leu Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu 
        275                 280                 285             


Trp Phe Tyr Ala His Ile Ile Pro Phe Leu Gly 
    290                 295                 


<210>  25
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-14 (BiP1-vIGF2-PPT1)

<400>  25

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Ala Met Leu Leu Leu Leu Ser Ala Ala Arg Ala Ser Arg Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser 
                85                  90                  95      


Gly Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Asp Pro Pro 
            100                 105                 110         


Ala Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys 
        115                 120                 125             


Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile 
    130                 135                 140                 


Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu 
145                 150                 155                 160 


Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr 
                165                 170                 175     


Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn 
            180                 185                 190         


Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln 
        195                 200                 205             


Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln 
    210                 215                 220                 


His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His 
225                 230                 235                 240 


Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys 
                245                 250                 255     


Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile 
            260                 265                 270         


Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn 
        275                 280                 285             


Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu 
    290                 295                 300                 


Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro 
305                 310                 315                 320 


Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu 
                325                 330                 335     


Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly 
            340                 345                 350         


Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu 
        355                 360                 365             


Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile 
    370                 375                 380                 


Pro Phe Leu Gly 
385             


<210>  26
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-15 (BiP1aa-vIGF2-PPT1)

<400>  26

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Ala Met Leu Leu Leu Leu Ser Ala Ala Arg Ala Ala Ala Ser Arg 
            20                  25                  30          


Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly 
        35                  40                  45              


Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg 
    50                  55                  60                  


Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala 
65                  70                  75                  80  


Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Asp 
            100                 105                 110         


Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser 
        115                 120                 125             


Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys 
    130                 135                 140                 


Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu 
145                 150                 155                 160 


Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val 
                165                 170                 175     


Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly 
            180                 185                 190         


Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val 
        195                 200                 205             


Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly 
    210                 215                 220                 


Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser 
225                 230                 235                 240 


Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr 
                245                 250                 255     


Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp 
            260                 265                 270         


Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp 
        275                 280                 285             


Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met 
    290                 295                 300                 


Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val 
305                 310                 315                 320 


Asp Pro Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala 
                325                 330                 335     


Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg 
            340                 345                 350         


Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala 
        355                 360                 365             


Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His 
    370                 375                 380                 


Ile Ile Pro Phe Leu Gly 
385                 390 


<210>  27
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-16 (BiP1aa-PPT1_2)

<400>  27

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Ala Met Leu Leu Leu Leu Ser Ala Ala Arg Ala Ala Ala Ser Arg 
            20                  25                  30          


Ala Leu Gln His Leu Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp 
        35                  40                  45              


His Gly Met Gly Asp Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile 
    50                  55                  60                  


Lys Lys Met Val Glu Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu 
65                  70                  75                  80  


Glu Ile Gly Lys Thr Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu 
                85                  90                  95      


Asn Val Asn Ser Gln Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp 
            100                 105                 110         


Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly 
        115                 120                 125             


Gln Phe Leu Arg Ala Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile 
    130                 135                 140                 


Asn Leu Ile Ser Val Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro 
145                 150                 155                 160 


Arg Cys Pro Gly Glu Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr 
                165                 170                 175     


Leu Asn Ala Gly Ala Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln 
            180                 185                 190         


Ala Glu Tyr Trp His Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His 
        195                 200                 205             


Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser 
    210                 215                 220                 


Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys Phe Val Met Val Lys Phe 
225                 230                 235                 240 


Leu Asn Asp Ser Ile Val Asp Pro Val Asp Ser Glu Trp Phe Gly Phe 
                245                 250                 255     


Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser 
            260                 265                 270         


Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly 
        275                 280                 285             


Gln Leu Val Phe Leu Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu 
    290                 295                 300                 


Glu Trp Phe Tyr Ala His Ile Ile Pro Phe Leu Gly 
305                 310                 315     


<210>  28
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-17(wt-PPT1-C6S)

<400>  28

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  29
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-18 (BiP2aa-PPT1

<400>  29

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Trp Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Arg Ala Ala Ala Ser Arg Ala Leu Gln 
            20                  25                  30          


His Leu Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His Gly Met 
        35                  40                  45              


Gly Asp Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met 
    50                  55                  60                  


Val Glu Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly 
65                  70                  75                  80  


Lys Thr Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn 
                85                  90                  95      


Ser Gln Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu 
            100                 105                 110         


Gln Gln Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu 
        115                 120                 125             


Arg Ala Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile 
    130                 135                 140                 


Ser Val Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro 
145                 150                 155                 160 


Gly Glu Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala 
                165                 170                 175     


Gly Ala Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr 
            180                 185                 190         


Trp His Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe 
        195                 200                 205             


Leu Ala Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys 
    210                 215                 220                 


Asn Leu Met Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp 
225                 230                 235                 240 


Ser Ile Val Asp Pro Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser 
                245                 250                 255     


Gly Gln Ala Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr 
            260                 265                 270         


Gln Asp Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val 
        275                 280                 285             


Phe Leu Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe 
    290                 295                 300                 


Tyr Ala His Ile Ile Pro Phe Leu Gly 
305                 310             


<210>  30
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-19 (GaussiaAA-PPT1_2)

<400>  30

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Ala Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro Leu 
            20                  25                  30          


Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro Leu 
        35                  40                  45              


Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly Ile 
    50                  55                  60                  


Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val Glu 
65                  70                  75                  80  


Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys Gln 
                85                  90                  95      


Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met Gly 
            100                 105                 110         


Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys Pro 
        115                 120                 125             


Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln Gly 
    130                 135                 140                 


Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys Asp 
145                 150                 155                 160 


Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val Gln 
                165                 170                 175     


Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu Asp 
            180                 185                 190         


Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg 
        195                 200                 205             


Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys Phe 
    210                 215                 220                 


Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp Ser 
225                 230                 235                 240 


Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile Pro 
                245                 250                 255     


Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys Glu 
            260                 265                 270         


Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp His 
        275                 280                 285             


Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe Leu 
    290                 295                 300                 


Gly 
305 


<210>  31
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-20 (GaussiaAA-vIGF2-PPT1)

<400>  31

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Ala Ala Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser 
        35                  40                  45              


Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg 
    50                  55                  60                  


Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg 
65                  70                  75                  80  


Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala 
                85                  90                  95      


Val Pro Thr Gln Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His 
            100                 105                 110         


Gly Met Gly Asp Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys 
        115                 120                 125             


Lys Met Val Glu Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu 
    130                 135                 140                 


Ile Gly Lys Thr Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn 
145                 150                 155                 160 


Val Asn Ser Gln Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro 
                165                 170                 175     


Lys Leu Gln Gln Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln 
            180                 185                 190         


Phe Leu Arg Ala Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn 
        195                 200                 205             


Leu Ile Ser Val Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg 
    210                 215                 220                 


Cys Pro Gly Glu Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu 
225                 230                 235                 240 


Asn Ala Gly Ala Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala 
                245                 250                 255     


Glu Tyr Trp His Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser 
            260                 265                 270         


Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr 
        275                 280                 285             


Lys Lys Asn Leu Met Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu 
    290                 295                 300                 


Asn Asp Ser Ile Val Asp Pro Val Asp Ser Glu Trp Phe Gly Phe Tyr 
305                 310                 315                 320 


Arg Ser Gly Gln Ala Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser Leu 
                325                 330                 335     


Tyr Thr Gln Asp Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln 
            340                 345                 350         


Leu Val Phe Leu Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu 
        355                 360                 365             


Trp Phe Tyr Ala His Ile Ile Pro Phe Leu Gly 
    370                 375                 


<210>  32
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-21 (ppt2ss-PPT1)

<400>  32

Met Leu Gly Leu Trp Gly Gln Arg Leu Pro Ala Ala Trp Val Leu Leu 
1               5                   10                  15      


Leu Leu Pro Phe Leu Pro Leu Leu Leu Leu Ala Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  33
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-22 (ppt2ss-PPT1_2)

<400>  33

Met Leu Gly Leu Trp Gly Gln Arg Leu Pro Ala Ala Trp Val Leu Leu 
1               5                   10                  15      


Leu Leu Pro Phe Leu Pro Leu Leu Leu Leu Ala Ser Arg Ala Leu Gln 
            20                  25                  30          


His Leu Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His Gly Met 
        35                  40                  45              


Gly Asp Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met 
    50                  55                  60                  


Val Glu Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly 
65                  70                  75                  80  


Lys Thr Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn 
                85                  90                  95      


Ser Gln Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu 
            100                 105                 110         


Gln Gln Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu 
        115                 120                 125             


Arg Ala Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile 
    130                 135                 140                 


Ser Val Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro 
145                 150                 155                 160 


Gly Glu Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala 
                165                 170                 175     


Gly Ala Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr 
            180                 185                 190         


Trp His Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe 
        195                 200                 205             


Leu Ala Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys 
    210                 215                 220                 


Asn Leu Met Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp 
225                 230                 235                 240 


Ser Ile Val Asp Pro Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser 
                245                 250                 255     


Gly Gln Ala Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr 
            260                 265                 270         


Gln Asp Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val 
        275                 280                 285             


Phe Leu Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe 
    290                 295                 300                 


Tyr Ala His Ile Ile Pro Phe Leu Gly 
305                 310             


<210>  34
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-23 (consensusSS-PPT1)

<400>  34

Met Ala Ser Pro Ser Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Ser Cys Ala Ala Arg Ala Leu Gly His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  35
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-24 (consensus-PPT1)

<400>  35

Met Ala Ser Pro Ser Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Ser Cys Ala Ala Arg Ala Leu Gly His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ile Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Ala Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Val Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Thr Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Lys Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Glu 
305     


<210>  36
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-25 (wt-PPT1 L283C H300C)

<400>  36

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Cys Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala Cys Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  37
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-26 (wt-PPT1 G113C L121C)

<400>  37

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Cys Phe Ser Gln Gly Gly Gln Phe Cys Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  38
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-27 (wt-PPT1 A171C A183C)

<400>  38

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Cys Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Cys Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly 
305     


<210>  39
<211>  313
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-28 (BiP2aa-PPT1)

<400>  39

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Trp Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Arg Ala Ala Ala Ser Arg Ala Leu Gln 
            20                  25                  30          


His Leu Asp Pro Pro Ala Pro Leu Pro Leu Val Ile Trp His Gly Met 
        35                  40                  45              


Gly Asp Ser Cys Cys Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met 
    50                  55                  60                  


Val Glu Lys Lys Ile Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly 
65                  70                  75                  80  


Lys Thr Leu Met Glu Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn 
                85                  90                  95      


Ser Gln Val Thr Thr Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu 
            100                 105                 110         


Gln Gln Gly Tyr Asn Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu 
        115                 120                 125             


Arg Ala Val Ala Gln Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile 
    130                 135                 140                 


Ser Val Gly Gly Gln His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro 
145                 150                 155                 160 


Gly Glu Ser Ser His Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala 
                165                 170                 175     


Gly Ala Tyr Ser Lys Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr 
            180                 185                 190         


Trp His Asp Pro Ile Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe 
        195                 200                 205             


Leu Ala Asp Ile Asn Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys 
    210                 215                 220                 


Asn Leu Met Ala Leu Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp 
225                 230                 235                 240 


Ser Ile Val Asp Pro Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser 
                245                 250                 255     


Gly Gln Ala Lys Glu Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr 
            260                 265                 270         


Gln Asp Arg Leu Gly Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val 
        275                 280                 285             


Phe Leu Ala Thr Glu Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe 
    290                 295                 300                 


Tyr Ala His Ile Ile Pro Phe Leu Gly 
305                 310             


<210>  40
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-31 (BiP1-vIGF2-PPT1

<400>  40

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Ala Met Leu Leu Leu Leu Ser Ala Ala Arg Ala Ser Arg Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser 
                85                  90                  95      


Gly Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Asp Pro Pro 
            100                 105                 110         


Ala Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys 
        115                 120                 125             


Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile 
    130                 135                 140                 


Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu 
145                 150                 155                 160 


Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr 
                165                 170                 175     


Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn 
            180                 185                 190         


Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln 
        195                 200                 205             


Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln 
    210                 215                 220                 


His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His 
225                 230                 235                 240 


Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys 
                245                 250                 255     


Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile 
            260                 265                 270         


Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn 
        275                 280                 285             


Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu 
    290                 295                 300                 


Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro 
305                 310                 315                 320 


Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu 
                325                 330                 335     


Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly 
            340                 345                 350         


Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu 
        355                 360                 365             


Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile 
    370                 375                 380                 


Pro Phe Leu Gly 
385             


<210>  41
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-32 (wt-PPT1-vIGF2-32)

<400>  41

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Thr Ser Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                325                 330                 335     


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly 
            340                 345                 350         


Gly Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Glu Cys Asp 
        355                 360                 365             


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    370                 375                 380             


<210>  42
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-33 (wt-PPT1-vIGF2-8Q)

<400>  42

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Thr Ser Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                325                 330                 335     


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala 
            340                 345                 350         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        355                 360                 365             


Arg Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    370                 375                 380                 


Arg Ser Glu 
385         


<210>  43
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-34 (wt-PPT1-vIGF2-8Q)

<400>  43

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Thr Ser Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                325                 330                 335     


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala 
            340                 345                 350         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        355                 360                 365             


Arg Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    370                 375                 380                 


Arg Ser Glu 
385         


<210>  44
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-35 (wt-PPT1-vIGF2-8Q)

<400>  44

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Thr Ser Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                325                 330                 335     


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala 
            340                 345                 350         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        355                 360                 365             


Arg Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    370                 375                 380                 


Arg Ser Glu 
385         


<210>  45
<211>  176
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TPP1 Propeptide

<400>  45

Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro Pro Gly Trp 
1               5                   10                  15      


Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser Leu Thr Phe 
            20                  25                  30          


Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu Val Gln Ala 
        35                  40                  45              


Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu Thr Leu Glu 
    50                  55                  60                  


Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu His Thr Val 
65                  70                  75                  80  


Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His Ser Val Ile 
                85                  90                  95      


Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln Ala Glu Leu 
            100                 105                 110         


Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly Pro Thr Glu 
        115                 120                 125             


Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro Gln Ala Leu 
    130                 135                 140                 


Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe Pro Pro Thr 
145                 150                 155                 160 


Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly Thr Val Gly 
                165                 170                 175     


<210>  46
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human TPP1 Mature Peptide

<400>  46

Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg Tyr Asn Leu 
1               5                   10                  15      


Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser Gln Ala Cys 
            20                  25                  30          


Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu Ala Gln Phe 
        35                  40                  45              


Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser Val Ala Arg 
    50                  55                  60                  


Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu Ala Ser Leu 
65                  70                  75                  80  


Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser Thr Trp Val 
                85                  90                  95      


Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe Leu Gln Trp 
            100                 105                 110         


Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val His Thr Val 
        115                 120                 125             


Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr Ile Gln Arg 
    130                 135                 140                 


Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu Thr Leu Leu 
145                 150                 155                 160 


Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val Ser Gly Arg 
                165                 170                 175     


His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr Val Thr Thr 
            180                 185                 190         


Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr Asn Glu Ile 
        195                 200                 205             


Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe Pro Arg Pro 
    210                 215                 220                 


Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser Ser Pro His 
225                 230                 235                 240 


Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala Tyr Pro Asp 
                245                 250                 255     


Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn Arg Val Pro 
            260                 265                 270         


Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val Phe Gly Gly 
        275                 280                 285             


Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly Arg Pro Pro 
    290                 295                 300                 


Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly Ala Gly Leu 
305                 310                 315                 320 


Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp Glu Glu Val 
                325                 330                 335     


Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro Val Thr Gly 
            340                 345                 350         


Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu Leu Asn Pro 
        355                 360                 365             


<210>  47
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSvelte001- Native TPP1 Signal Peptide - vIGF2 - GS linker - Lyso
       Cleave - TPP1 propeptide - TPP1 mature peptide

<400>  47

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser 
        35                  40                  45              


Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg 
    50                  55                  60                  


Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg 
65                  70                  75                  80  


Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala 
                85                  90                  95      


Val Pro Thr Gln Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu 
            100                 105                 110         


Pro Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu 
        115                 120                 125             


Ser Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu 
    130                 135                 140                 


Leu Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr 
145                 150                 155                 160 


Leu Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr 
                165                 170                 175     


Leu His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys 
            180                 185                 190         


His Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg 
        195                 200                 205             


Gln Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly 
    210                 215                 220                 


Gly Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu 
225                 230                 235                 240 


Pro Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg 
                245                 250                 255     


Phe Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr 
            260                 265                 270         


Gly Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys 
        275                 280                 285             


Arg Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn 
    290                 295                 300                 


Ser Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp 
305                 310                 315                 320 


Leu Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala 
                325                 330                 335     


Ser Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile 
            340                 345                 350         


Glu Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile 
        355                 360                 365             


Ser Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro 
    370                 375                 380                 


Phe Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His 
385                 390                 395                 400 


Val His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala 
                405                 410                 415     


Tyr Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly 
            420                 425                 430         


Leu Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser 
        435                 440                 445             


Val Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro 
    450                 455                 460                 


Tyr Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile 
465                 470                 475                 480 


Thr Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val 
                485                 490                 495     


Phe Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser 
            500                 505                 510         


Ser Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg 
        515                 520                 525             


Ala Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser 
    530                 535                 540                 


Asn Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro 
545                 550                 555                 560 


Val Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser 
                565                 570                 575     


Gly Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His 
            580                 585                 590         


Gly Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu 
        595                 600                 605             


Asp Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp 
    610                 615                 620                 


Pro Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr 
625                 630                 635                 640 


Leu Leu Asn Pro Gly 
                645 


<210>  48
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Svelte057 - Native TPP1 Signal Peptide - vIGF2v17 - GS linker - 
       Lyso Cleave - TPP1 propeptide - TPP1 mature peptide

<400>  48

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser 
        35                  40                  45              


Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg 
    50                  55                  60                  


Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg 
65                  70                  75                  80  


Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala 
                85                  90                  95      


Val Pro Thr Gln Ala Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr 
            100                 105                 110         


Leu Pro Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu 
        115                 120                 125             


Leu Ser Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser 
    130                 135                 140                 


Glu Leu Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys 
145                 150                 155                 160 


Tyr Leu Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu 
                165                 170                 175     


Thr Leu His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys 
            180                 185                 190         


Cys His Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile 
        195                 200                 205             


Arg Gln Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val 
    210                 215                 220                 


Gly Gly Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln 
225                 230                 235                 240 


Leu Pro Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His 
                245                 250                 255     


Arg Phe Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val 
            260                 265                 270         


Thr Gly Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg 
        275                 280                 285             


Lys Arg Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn 
    290                 295                 300                 


Asn Ser Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser 
305                 310                 315                 320 


Asp Leu Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln 
                325                 330                 335     


Ala Ser Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly 
            340                 345                 350         


Ile Glu Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn 
        355                 360                 365             


Ile Ser Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu 
    370                 375                 380                 


Pro Phe Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro 
385                 390                 395                 400 


His Val His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser 
                405                 410                 415     


Ala Tyr Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg 
            420                 425                 430         


Gly Leu Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp 
        435                 440                 445             


Ser Val Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser 
    450                 455                 460                 


Pro Tyr Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu 
465                 470                 475                 480 


Ile Thr Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn 
                485                 490                 495     


Val Phe Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu 
            500                 505                 510         


Ser Ser Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly 
        515                 520                 525             


Arg Ala Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val 
    530                 535                 540                 


Ser Asn Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr 
545                 550                 555                 560 


Pro Val Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu 
                565                 570                 575     


Ser Gly Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln 
            580                 585                 590         


His Gly Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys 
        595                 600                 605             


Leu Asp Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp 
    610                 615                 620                 


Asp Pro Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys 
625                 630                 635                 640 


Thr Leu Leu Asn Pro Gly 
                645     


<210>  49
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSvelte059 -Native TPP1 Signal Peptide - vIGF2v22 - GS linker - 
       Lyso Cleave - TPP1 propeptide - TPP1 mature peptide

<400>  49

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly 
        35                  40                  45              


Gly Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu 
    50                  55                  60                  


Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln 
                85                  90                  95      


Ala Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro Pro Gly 
            100                 105                 110         


Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser Leu Thr 
        115                 120                 125             


Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu Val Gln 
    130                 135                 140                 


Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu Thr Leu 
145                 150                 155                 160 


Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu His Thr 
                165                 170                 175     


Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His Ser Val 
            180                 185                 190         


Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln Ala Glu 
        195                 200                 205             


Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly Pro Thr 
    210                 215                 220                 


Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro Gln Ala 
225                 230                 235                 240 


Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe Pro Pro 
                245                 250                 255     


Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly Thr Val 
            260                 265                 270         


Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg Tyr Asn 
        275                 280                 285             


Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser Gln Ala 
    290                 295                 300                 


Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu Ala Gln 
305                 310                 315                 320 


Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser Val Ala 
                325                 330                 335     


Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu Ala Ser 
            340                 345                 350         


Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser Thr Trp 
        355                 360                 365             


Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe Leu Gln 
    370                 375                 380                 


Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val His Thr 
385                 390                 395                 400 


Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr Ile Gln 
                405                 410                 415     


Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu Thr Leu 
            420                 425                 430         


Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val Ser Gly 
        435                 440                 445             


Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr Val Thr 
    450                 455                 460                 


Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr Asn Glu 
465                 470                 475                 480 


Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe Pro Arg 
                485                 490                 495     


Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser Ser Pro 
            500                 505                 510         


His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala Tyr Pro 
        515                 520                 525             


Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn Arg Val 
    530                 535                 540                 


Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val Phe Gly 
545                 550                 555                 560 


Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly Arg Pro 
                565                 570                 575     


Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly Ala Gly 
            580                 585                 590         


Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp Glu Glu 
        595                 600                 605             


Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro Val Thr 
    610                 615                 620                 


Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu Leu Asn 
625                 630                 635                 640 


Pro Gly 
        


<210>  50
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSvelte060 - Native TPP1 Signal Peptide - vIGF2v24- GS linker - 
       Lyso Cleave - TPP1 propeptide - TPP1 mature peptide

<400>  50

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly 
        35                  40                  45              


Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu 
    50                  55                  60                  


Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln 
                85                  90                  95      


Ala Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro Pro Gly 
            100                 105                 110         


Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser Leu Thr 
        115                 120                 125             


Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu Val Gln 
    130                 135                 140                 


Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu Thr Leu 
145                 150                 155                 160 


Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu His Thr 
                165                 170                 175     


Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His Ser Val 
            180                 185                 190         


Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln Ala Glu 
        195                 200                 205             


Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly Pro Thr 
    210                 215                 220                 


Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro Gln Ala 
225                 230                 235                 240 


Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe Pro Pro 
                245                 250                 255     


Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly Thr Val 
            260                 265                 270         


Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg Tyr Asn 
        275                 280                 285             


Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser Gln Ala 
    290                 295                 300                 


Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu Ala Gln 
305                 310                 315                 320 


Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser Val Ala 
                325                 330                 335     


Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu Ala Ser 
            340                 345                 350         


Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser Thr Trp 
        355                 360                 365             


Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe Leu Gln 
    370                 375                 380                 


Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val His Thr 
385                 390                 395                 400 


Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr Ile Gln 
                405                 410                 415     


Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu Thr Leu 
            420                 425                 430         


Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val Ser Gly 
        435                 440                 445             


Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr Val Thr 
    450                 455                 460                 


Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr Asn Glu 
465                 470                 475                 480 


Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe Pro Arg 
                485                 490                 495     


Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser Ser Pro 
            500                 505                 510         


His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala Tyr Pro 
        515                 520                 525             


Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn Arg Val 
    530                 535                 540                 


Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val Phe Gly 
545                 550                 555                 560 


Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly Arg Pro 
                565                 570                 575     


Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly Ala Gly 
            580                 585                 590         


Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp Glu Glu 
        595                 600                 605             


Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro Val Thr 
    610                 615                 620                 


Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu Leu Asn 
625                 630                 635                 640 


Pro Gly 
        


<210>  51
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSvelte061- Native TPP1 Signal Peptide - vIGF2v30 - GS linker - 
       Lyso Cleave - TPP1 propeptide - TPP1 mature peptide

<400>  51

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Val Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Arg Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser 
        35                  40                  45              


Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg 
    50                  55                  60                  


Asp Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg 
65                  70                  75                  80  


Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala 
                85                  90                  95      


Val Pro Thr Gln Ala Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr 
            100                 105                 110         


Leu Pro Pro Gly Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu 
        115                 120                 125             


Leu Ser Leu Thr Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser 
    130                 135                 140                 


Glu Leu Val Gln Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys 
145                 150                 155                 160 


Tyr Leu Thr Leu Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu 
                165                 170                 175     


Thr Leu His Thr Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys 
            180                 185                 190         


Cys His Ser Val Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile 
        195                 200                 205             


Arg Gln Ala Glu Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val 
    210                 215                 220                 


Gly Gly Pro Thr Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln 
225                 230                 235                 240 


Leu Pro Gln Ala Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His 
                245                 250                 255     


Arg Phe Pro Pro Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val 
            260                 265                 270         


Thr Gly Thr Val Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg 
        275                 280                 285             


Lys Arg Tyr Asn Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn 
    290                 295                 300                 


Asn Ser Gln Ala Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser 
305                 310                 315                 320 


Asp Leu Ala Gln Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln 
                325                 330                 335     


Ala Ser Val Ala Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly 
            340                 345                 350         


Ile Glu Ala Ser Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn 
        355                 360                 365             


Ile Ser Thr Trp Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu 
    370                 375                 380                 


Pro Phe Leu Gln Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro 
385                 390                 395                 400 


His Val His Thr Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser 
                405                 410                 415     


Ala Tyr Ile Gln Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg 
            420                 425                 430         


Gly Leu Thr Leu Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp 
        435                 440                 445             


Ser Val Ser Gly Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser 
    450                 455                 460                 


Pro Tyr Val Thr Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu 
465                 470                 475                 480 


Ile Thr Asn Glu Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn 
                485                 490                 495     


Val Phe Pro Arg Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu 
            500                 505                 510         


Ser Ser Ser Pro His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly 
        515                 520                 525             


Arg Ala Tyr Pro Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val 
    530                 535                 540                 


Ser Asn Arg Val Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr 
545                 550                 555                 560 


Pro Val Phe Gly Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu 
                565                 570                 575     


Ser Gly Arg Pro Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln 
            580                 585                 590         


His Gly Ala Gly Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys 
        595                 600                 605             


Leu Asp Glu Glu Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp 
    610                 615                 620                 


Asp Pro Val Thr Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys 
625                 630                 635                 640 


Thr Leu Leu Asn Pro Gly 
                645     


<210>  52
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSvelte062- Native TPP1 Signal Peptide - vIGF2v31 - GS linker - 
       Lyso Cleave - TPP1 propeptide - TPP1 mature peptide

<400>  52

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly 
        35                  40                  45              


Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Asp Cys Asp Leu 
    50                  55                  60                  


Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln 
                85                  90                  95      


Ala Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro Pro Gly 
            100                 105                 110         


Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser Leu Thr 
        115                 120                 125             


Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu Val Gln 
    130                 135                 140                 


Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu Thr Leu 
145                 150                 155                 160 


Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu His Thr 
                165                 170                 175     


Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His Ser Val 
            180                 185                 190         


Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln Ala Glu 
        195                 200                 205             


Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly Pro Thr 
    210                 215                 220                 


Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro Gln Ala 
225                 230                 235                 240 


Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe Pro Pro 
                245                 250                 255     


Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly Thr Val 
            260                 265                 270         


Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg Tyr Asn 
        275                 280                 285             


Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser Gln Ala 
    290                 295                 300                 


Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu Ala Gln 
305                 310                 315                 320 


Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser Val Ala 
                325                 330                 335     


Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu Ala Ser 
            340                 345                 350         


Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser Thr Trp 
        355                 360                 365             


Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe Leu Gln 
    370                 375                 380                 


Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val His Thr 
385                 390                 395                 400 


Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr Ile Gln 
                405                 410                 415     


Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu Thr Leu 
            420                 425                 430         


Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val Ser Gly 
        435                 440                 445             


Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr Val Thr 
    450                 455                 460                 


Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr Asn Glu 
465                 470                 475                 480 


Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe Pro Arg 
                485                 490                 495     


Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser Ser Pro 
            500                 505                 510         


His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala Tyr Pro 
        515                 520                 525             


Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn Arg Val 
    530                 535                 540                 


Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val Phe Gly 
545                 550                 555                 560 


Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly Arg Pro 
                565                 570                 575     


Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly Ala Gly 
            580                 585                 590         


Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp Glu Glu 
        595                 600                 605             


Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro Val Thr 
    610                 615                 620                 


Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu Leu Asn 
625                 630                 635                 640 


Pro Gly 
        


<210>  53
<211>  642
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pSvelte063- Native TPP1 Signal Peptide - vIGF2v32 - GS linker - 
       Lyso Cleave - TPP1 propeptide - TPP1 mature peptide

<400>  53

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu 
            20                  25                  30          


Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly 
        35                  40                  45              


Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Glu Cys Asp Leu 
    50                  55                  60                  


Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr Gln 
                85                  90                  95      


Ala Ser Tyr Ser Pro Glu Pro Asp Gln Arg Arg Thr Leu Pro Pro Gly 
            100                 105                 110         


Trp Val Ser Leu Gly Arg Ala Asp Pro Glu Glu Glu Leu Ser Leu Thr 
        115                 120                 125             


Phe Ala Leu Arg Gln Gln Asn Val Glu Arg Leu Ser Glu Leu Val Gln 
    130                 135                 140                 


Ala Val Ser Asp Pro Ser Ser Pro Gln Tyr Gly Lys Tyr Leu Thr Leu 
145                 150                 155                 160 


Glu Asn Val Ala Asp Leu Val Arg Pro Ser Pro Leu Thr Leu His Thr 
                165                 170                 175     


Val Gln Lys Trp Leu Leu Ala Ala Gly Ala Gln Lys Cys His Ser Val 
            180                 185                 190         


Ile Thr Gln Asp Phe Leu Thr Cys Trp Leu Ser Ile Arg Gln Ala Glu 
        195                 200                 205             


Leu Leu Leu Pro Gly Ala Glu Phe His His Tyr Val Gly Gly Pro Thr 
    210                 215                 220                 


Glu Thr His Val Val Arg Ser Pro His Pro Tyr Gln Leu Pro Gln Ala 
225                 230                 235                 240 


Leu Ala Pro His Val Asp Phe Val Gly Gly Leu His Arg Phe Pro Pro 
                245                 250                 255     


Thr Ser Ser Leu Arg Gln Arg Pro Glu Pro Gln Val Thr Gly Thr Val 
            260                 265                 270         


Gly Leu His Leu Gly Val Thr Pro Ser Val Ile Arg Lys Arg Tyr Asn 
        275                 280                 285             


Leu Thr Ser Gln Asp Val Gly Ser Gly Thr Ser Asn Asn Ser Gln Ala 
    290                 295                 300                 


Cys Ala Gln Phe Leu Glu Gln Tyr Phe His Asp Ser Asp Leu Ala Gln 
305                 310                 315                 320 


Phe Met Arg Leu Phe Gly Gly Asn Phe Ala His Gln Ala Ser Val Ala 
                325                 330                 335     


Arg Val Val Gly Gln Gln Gly Arg Gly Arg Ala Gly Ile Glu Ala Ser 
            340                 345                 350         


Leu Asp Val Gln Tyr Leu Met Ser Ala Gly Ala Asn Ile Ser Thr Trp 
        355                 360                 365             


Val Tyr Ser Ser Pro Gly Arg His Glu Gly Gln Glu Pro Phe Leu Gln 
    370                 375                 380                 


Trp Leu Met Leu Leu Ser Asn Glu Ser Ala Leu Pro His Val His Thr 
385                 390                 395                 400 


Val Ser Tyr Gly Asp Asp Glu Asp Ser Leu Ser Ser Ala Tyr Ile Gln 
                405                 410                 415     


Arg Val Asn Thr Glu Leu Met Lys Ala Ala Ala Arg Gly Leu Thr Leu 
            420                 425                 430         


Leu Phe Ala Ser Gly Asp Ser Gly Ala Gly Cys Trp Ser Val Ser Gly 
        435                 440                 445             


Arg His Gln Phe Arg Pro Thr Phe Pro Ala Ser Ser Pro Tyr Val Thr 
    450                 455                 460                 


Thr Val Gly Gly Thr Ser Phe Gln Glu Pro Phe Leu Ile Thr Asn Glu 
465                 470                 475                 480 


Ile Val Asp Tyr Ile Ser Gly Gly Gly Phe Ser Asn Val Phe Pro Arg 
                485                 490                 495     


Pro Ser Tyr Gln Glu Glu Ala Val Thr Lys Phe Leu Ser Ser Ser Pro 
            500                 505                 510         


His Leu Pro Pro Ser Ser Tyr Phe Asn Ala Ser Gly Arg Ala Tyr Pro 
        515                 520                 525             


Asp Val Ala Ala Leu Ser Asp Gly Tyr Trp Val Val Ser Asn Arg Val 
    530                 535                 540                 


Pro Ile Pro Trp Val Ser Gly Thr Ser Ala Ser Thr Pro Val Phe Gly 
545                 550                 555                 560 


Gly Ile Leu Ser Leu Ile Asn Glu His Arg Ile Leu Ser Gly Arg Pro 
                565                 570                 575     


Pro Leu Gly Phe Leu Asn Pro Arg Leu Tyr Gln Gln His Gly Ala Gly 
            580                 585                 590         


Leu Phe Asp Val Thr Arg Gly Cys His Glu Ser Cys Leu Asp Glu Glu 
        595                 600                 605             


Val Glu Gly Gln Gly Phe Cys Ser Gly Pro Gly Trp Asp Pro Val Thr 
    610                 615                 620                 


Gly Trp Gly Thr Pro Asn Phe Pro Ala Leu Leu Lys Thr Leu Leu Asn 
625                 630                 635                 640 


Pro Gly 
        


<210>  54
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wt-NAGLU

<400>  54

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Glu Ala Arg Glu Ala Ala Ala Val 
            20                  25                  30          


Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe 
        35                  40                  45              


Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr 
    50                  55                  60                  


Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser 
65                  70                  75                  80  


Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe 
                85                  90                  95      


Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg 
            100                 105                 110         


Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg 
        115                 120                 125             


Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp 
    130                 135                 140                 


Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn 
145                 150                 155                 160 


Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln 
                165                 170                 175     


Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe 
            180                 185                 190         


Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His 
        195                 200                 205             


Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr 
    210                 215                 220                 


Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro 
225                 230                 235                 240 


Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val 
                245                 250                 255     


Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn 
            260                 265                 270         


Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe 
        275                 280                 285             


Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly 
    290                 295                 300                 


Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro 
305                 310                 315                 320 


Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu 
                325                 330                 335     


Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp 
            340                 345                 350         


Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala 
        355                 360                 365             


Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe 
    370                 375                 380                 


Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln 
385                 390                 395                 400 


Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu 
                405                 410                 415     


Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu 
            420                 425                 430         


Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile 
        435                 440                 445             


Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg 
    450                 455                 460                 


Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala 
465                 470                 475                 480 


Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu 
                485                 490                 495     


Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His 
            500                 505                 510         


Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser 
        515                 520                 525             


Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu 
    530                 535                 540                 


Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu 
545                 550                 555                 560 


Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr 
                565                 570                 575     


Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu 
            580                 585                 590         


Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu 
        595                 600                 605             


Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln 
    610                 615                 620                 


Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln 
625                 630                 635                 640 


Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu 
                645                 650                 655     


Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr 
            660                 665                 670         


Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln 
        675                 680                 685             


Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu 
    690                 695                 700                 


Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg 
705                 710                 715                 720 


Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro 
                725                 730                 735     


Arg Trp Val Ala Gly Ser Trp 
            740             


<210>  55
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wt NAGLU-HPC4

<400>  55

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Glu Ala Arg Glu Ala Ala Ala Val 
            20                  25                  30          


Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe 
        35                  40                  45              


Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr 
    50                  55                  60                  


Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser 
65                  70                  75                  80  


Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe 
                85                  90                  95      


Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg 
            100                 105                 110         


Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg 
        115                 120                 125             


Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp 
    130                 135                 140                 


Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn 
145                 150                 155                 160 


Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln 
                165                 170                 175     


Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe 
            180                 185                 190         


Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His 
        195                 200                 205             


Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr 
    210                 215                 220                 


Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro 
225                 230                 235                 240 


Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val 
                245                 250                 255     


Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn 
            260                 265                 270         


Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe 
        275                 280                 285             


Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly 
    290                 295                 300                 


Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro 
305                 310                 315                 320 


Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu 
                325                 330                 335     


Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp 
            340                 345                 350         


Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala 
        355                 360                 365             


Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe 
    370                 375                 380                 


Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln 
385                 390                 395                 400 


Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu 
                405                 410                 415     


Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu 
            420                 425                 430         


Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile 
        435                 440                 445             


Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg 
    450                 455                 460                 


Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala 
465                 470                 475                 480 


Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu 
                485                 490                 495     


Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His 
            500                 505                 510         


Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser 
        515                 520                 525             


Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu 
    530                 535                 540                 


Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu 
545                 550                 555                 560 


Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr 
                565                 570                 575     


Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu 
            580                 585                 590         


Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu 
        595                 600                 605             


Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln 
    610                 615                 620                 


Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln 
625                 630                 635                 640 


Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu 
                645                 650                 655     


Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr 
            660                 665                 670         


Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln 
        675                 680                 685             


Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu 
    690                 695                 700                 


Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg 
705                 710                 715                 720 


Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro 
                725                 730                 735     


Arg Trp Val Ala Gly Ser Trp Gly Leu Glu Val Leu Phe Gln Gly Pro 
            740                 745                 750         


Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
        755                 760                 


<210>  56
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-NAGLU-HPC4

<400>  56

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Ala Ser Arg Thr Leu Cys Gly Gly 
            20                  25                  30          


Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu 
        35                  40                  45              


Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val 
    50                  55                  60                  


Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr 
65                  70                  75                  80  


Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Ala Glu Ala Arg Glu Ala 
            100                 105                 110         


Ala Ala Val Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala 
        115                 120                 125             


Ala Asp Phe Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly 
    130                 135                 140                 


Leu Asp Thr Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val 
145                 150                 155                 160 


Arg Gly Ser Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu 
                165                 170                 175     


Arg Asp Phe Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg 
            180                 185                 190         


Leu Pro Arg Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr 
        195                 200                 205             


Pro Asn Arg Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser 
    210                 215                 220                 


Phe Val Trp Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met 
225                 230                 235                 240 


Ala Leu Asn Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala 
                245                 250                 255     


Ile Trp Gln Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile 
            260                 265                 270         


Asn Glu Phe Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly 
        275                 280                 285             


Asn Leu His Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys 
    290                 295                 300                 


Gln Leu Tyr Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly 
305                 310                 315                 320 


Met Thr Pro Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val 
                325                 330                 335     


Thr Arg Val Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly 
            340                 345                 350         


His Phe Asn Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp 
        355                 360                 365             


Pro Ile Phe Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys 
    370                 375                 380                 


Glu Phe Gly Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met 
385                 390                 395                 400 


Gln Pro Pro Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala 
                405                 410                 415     


Val Tyr Glu Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu 
            420                 425                 430         


Gln Gly Trp Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln 
        435                 440                 445             


Ile Arg Ala Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu 
    450                 455                 460                 


Asp Leu Phe Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe 
465                 470                 475                 480 


Gln Gly Gln Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn 
                485                 490                 495     


His Gly Leu Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala 
            500                 505                 510         


Ala Arg Leu Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro 
        515                 520                 525             


Glu Gly Ile Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu 
    530                 535                 540                 


Gly Trp Arg Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser 
545                 550                 555                 560 


Phe Ala Ala Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala 
                565                 570                 575     


Trp Arg Leu Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys 
            580                 585                 590         


Arg Gly His Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met 
        595                 600                 605             


Asn Thr Ser Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg 
    610                 615                 620                 


Leu Leu Leu Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg 
625                 630                 635                 640 


Tyr Asp Leu Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser 
                645                 650                 655     


Leu Tyr Tyr Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala 
            660                 665                 670         


Ser Leu Leu Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala 
        675                 680                 685             


Leu Asp Glu Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp 
    690                 695                 700                 


Leu Glu Gln Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe 
705                 710                 715                 720 


Tyr Glu Gln Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly 
                725                 730                 735     


Asn Ile Leu Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn 
            740                 745                 750         


Tyr Tyr Thr Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser 
        755                 760                 765             


Val Ala Gln Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val 
    770                 775                 780                 


Phe Gln Leu Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser 
785                 790                 795                 800 


Gln Pro Arg Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys 
                805                 810                 815     


Tyr Tyr Pro Arg Trp Val Ala Gly Ser Trp Gly Leu Glu Val Leu Phe 
            820                 825                 830         


Gln Gly Pro Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
        835                 840                 845         


<210>  57
<211>  847
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-17-NAGLU

<400>  57

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Ala Ser Arg Thr Leu Cys Gly Gly 
            20                  25                  30          


Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu 
        35                  40                  45              


Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val 
    50                  55                  60                  


Glu Glu Cys Cys Phe Arg Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr 
65                  70                  75                  80  


Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Ala Glu Ala Arg Glu Ala 
            100                 105                 110         


Ala Ala Val Arg Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala 
        115                 120                 125             


Ala Asp Phe Ser Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly 
    130                 135                 140                 


Leu Asp Thr Tyr Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val 
145                 150                 155                 160 


Arg Gly Ser Thr Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu 
                165                 170                 175     


Arg Asp Phe Cys Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg 
            180                 185                 190         


Leu Pro Arg Pro Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr 
        195                 200                 205             


Pro Asn Arg Tyr Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser 
    210                 215                 220                 


Phe Val Trp Trp Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met 
225                 230                 235                 240 


Ala Leu Asn Gly Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala 
                245                 250                 255     


Ile Trp Gln Arg Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile 
            260                 265                 270         


Asn Glu Phe Phe Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly 
        275                 280                 285             


Asn Leu His Thr Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys 
    290                 295                 300                 


Gln Leu Tyr Leu Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly 
305                 310                 315                 320 


Met Thr Pro Val Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val 
                325                 330                 335     


Thr Arg Val Phe Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly 
            340                 345                 350         


His Phe Asn Cys Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp 
        355                 360                 365             


Pro Ile Phe Pro Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys 
    370                 375                 380                 


Glu Phe Gly Thr Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met 
385                 390                 395                 400 


Gln Pro Pro Ser Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala 
                405                 410                 415     


Val Tyr Glu Ala Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu 
            420                 425                 430         


Gln Gly Trp Leu Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln 
        435                 440                 445             


Ile Arg Ala Val Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu 
    450                 455                 460                 


Asp Leu Phe Ala Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe 
465                 470                 475                 480 


Gln Gly Gln Pro Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn 
                485                 490                 495     


His Gly Leu Phe Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala 
            500                 505                 510         


Ala Arg Leu Phe Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro 
        515                 520                 525             


Glu Gly Ile Ser Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu 
    530                 535                 540                 


Gly Trp Arg Lys Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser 
545                 550                 555                 560 


Phe Ala Ala Arg Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala 
                565                 570                 575     


Trp Arg Leu Leu Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys 
            580                 585                 590         


Arg Gly His Asn Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met 
        595                 600                 605             


Asn Thr Ser Ile Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg 
    610                 615                 620                 


Leu Leu Leu Thr Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg 
625                 630                 635                 640 


Tyr Asp Leu Leu Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser 
                645                 650                 655     


Leu Tyr Tyr Glu Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala 
            660                 665                 670         


Ser Leu Leu Arg Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala 
        675                 680                 685             


Leu Asp Glu Val Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp 
    690                 695                 700                 


Leu Glu Gln Ala Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe 
705                 710                 715                 720 


Tyr Glu Gln Asn Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly 
                725                 730                 735     


Asn Ile Leu Asp Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn 
            740                 745                 750         


Tyr Tyr Thr Pro Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser 
        755                 760                 765             


Val Ala Gln Gly Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val 
    770                 775                 780                 


Phe Gln Leu Glu Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser 
785                 790                 795                 800 


Gln Pro Arg Gly Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys 
                805                 810                 815     


Tyr Tyr Pro Arg Trp Val Ala Gly Ser Trp Gly Leu Glu Val Leu Phe 
            820                 825                 830         


Gln Gly Pro Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
        835                 840                 845         


<210>  58
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-31-NAGLU-HPC4

<400>  58

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Ala Ser Arg Thr Leu Cys Gly Gly 
            20                  25                  30          


Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu 
        35                  40                  45              


Phe Ser Arg Gly Gly Gly Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys 
    50                  55                  60                  


Phe Arg Asp Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro 
65                  70                  75                  80  


Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro 
                85                  90                  95      


Arg Ala Val Pro Thr Gln Ala Glu Ala Arg Glu Ala Ala Ala Val Arg 
            100                 105                 110         


Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe Ser 
        115                 120                 125             


Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr Tyr 
    130                 135                 140                 


Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser Thr 
145                 150                 155                 160 


Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe Cys 
                165                 170                 175     


Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg Pro 
            180                 185                 190         


Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg Tyr 
        195                 200                 205             


Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp Trp 
    210                 215                 220                 


Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn Gly 
225                 230                 235                 240 


Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln Arg 
                245                 250                 255     


Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe Phe 
            260                 265                 270         


Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His Thr 
        275                 280                 285             


Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr Leu 
    290                 295                 300                 


Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro Val 
305                 310                 315                 320 


Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val Phe 
                325                 330                 335     


Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn Cys 
            340                 345                 350         


Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe Pro 
        355                 360                 365             


Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly Thr 
    370                 375                 380                 


Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro Ser 
385                 390                 395                 400 


Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu Ala 
                405                 410                 415     


Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp Leu 
            420                 425                 430         


Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala Val 
        435                 440                 445             


Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe Ala 
    450                 455                 460                 


Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln Pro 
465                 470                 475                 480 


Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu Phe 
                485                 490                 495     


Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu Phe 
            500                 505                 510         


Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile Ser 
        515                 520                 525             


Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg Lys 
    530                 535                 540                 


Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala Arg 
545                 550                 555                 560 


Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu Leu 
                565                 570                 575     


Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His Asn 
            580                 585                 590         


Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser Ile 
        595                 600                 605             


Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu Thr 
    610                 615                 620                 


Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu Leu 
625                 630                 635                 640 


Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr Glu 
                645                 650                 655     


Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu Arg 
            660                 665                 670         


Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu Val 
        675                 680                 685             


Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln Ala 
    690                 695                 700                 


Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln Asn 
705                 710                 715                 720 


Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu Asp 
                725                 730                 735     


Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr Pro 
            740                 745                 750         


Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln Gly 
        755                 760                 765             


Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu Glu 
    770                 775                 780                 


Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg Gly 
785                 790                 795                 800 


Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro Arg 
                805                 810                 815     


Trp Val Ala Gly Ser Trp Gly Leu Glu Val Leu Phe Gln Gly Pro Glu 
            820                 825                 830         


Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
        835                 840             


<210>  59
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-32-NAGLU

<400>  59

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp Ala Ser Arg Thr Leu Cys Gly Gly 
            20                  25                  30          


Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu 
        35                  40                  45              


Phe Ser Arg Gly Gly Gly Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys 
    50                  55                  60                  


Phe Arg Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro 
65                  70                  75                  80  


Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro 
                85                  90                  95      


Arg Ala Val Pro Thr Gln Ala Glu Ala Arg Glu Ala Ala Ala Val Arg 
            100                 105                 110         


Ala Leu Val Ala Arg Leu Leu Gly Pro Gly Pro Ala Ala Asp Phe Ser 
        115                 120                 125             


Val Ser Val Glu Arg Ala Leu Ala Ala Lys Pro Gly Leu Asp Thr Tyr 
    130                 135                 140                 


Ser Leu Gly Gly Gly Gly Ala Ala Arg Val Arg Val Arg Gly Ser Thr 
145                 150                 155                 160 


Gly Val Ala Ala Ala Ala Gly Leu His Arg Tyr Leu Arg Asp Phe Cys 
                165                 170                 175     


Gly Cys His Val Ala Trp Ser Gly Ser Gln Leu Arg Leu Pro Arg Pro 
            180                 185                 190         


Leu Pro Ala Val Pro Gly Glu Leu Thr Glu Ala Thr Pro Asn Arg Tyr 
        195                 200                 205             


Arg Tyr Tyr Gln Asn Val Cys Thr Gln Ser Tyr Ser Phe Val Trp Trp 
    210                 215                 220                 


Asp Trp Ala Arg Trp Glu Arg Glu Ile Asp Trp Met Ala Leu Asn Gly 
225                 230                 235                 240 


Ile Asn Leu Ala Leu Ala Trp Ser Gly Gln Glu Ala Ile Trp Gln Arg 
                245                 250                 255     


Val Tyr Leu Ala Leu Gly Leu Thr Gln Ala Glu Ile Asn Glu Phe Phe 
            260                 265                 270         


Thr Gly Pro Ala Phe Leu Ala Trp Gly Arg Met Gly Asn Leu His Thr 
        275                 280                 285             


Trp Asp Gly Pro Leu Pro Pro Ser Trp His Ile Lys Gln Leu Tyr Leu 
    290                 295                 300                 


Gln His Arg Val Leu Asp Gln Met Arg Ser Phe Gly Met Thr Pro Val 
305                 310                 315                 320 


Leu Pro Ala Phe Ala Gly His Val Pro Glu Ala Val Thr Arg Val Phe 
                325                 330                 335     


Pro Gln Val Asn Val Thr Lys Met Gly Ser Trp Gly His Phe Asn Cys 
            340                 345                 350         


Ser Tyr Ser Cys Ser Phe Leu Leu Ala Pro Glu Asp Pro Ile Phe Pro 
        355                 360                 365             


Ile Ile Gly Ser Leu Phe Leu Arg Glu Leu Ile Lys Glu Phe Gly Thr 
    370                 375                 380                 


Asp His Ile Tyr Gly Ala Asp Thr Phe Asn Glu Met Gln Pro Pro Ser 
385                 390                 395                 400 


Ser Glu Pro Ser Tyr Leu Ala Ala Ala Thr Thr Ala Val Tyr Glu Ala 
                405                 410                 415     


Met Thr Ala Val Asp Thr Glu Ala Val Trp Leu Leu Gln Gly Trp Leu 
            420                 425                 430         


Phe Gln His Gln Pro Gln Phe Trp Gly Pro Ala Gln Ile Arg Ala Val 
        435                 440                 445             


Leu Gly Ala Val Pro Arg Gly Arg Leu Leu Val Leu Asp Leu Phe Ala 
    450                 455                 460                 


Glu Ser Gln Pro Val Tyr Thr Arg Thr Ala Ser Phe Gln Gly Gln Pro 
465                 470                 475                 480 


Phe Ile Trp Cys Met Leu His Asn Phe Gly Gly Asn His Gly Leu Phe 
                485                 490                 495     


Gly Ala Leu Glu Ala Val Asn Gly Gly Pro Glu Ala Ala Arg Leu Phe 
            500                 505                 510         


Pro Asn Ser Thr Met Val Gly Thr Gly Met Ala Pro Glu Gly Ile Ser 
        515                 520                 525             


Gln Asn Glu Val Val Tyr Ser Leu Met Ala Glu Leu Gly Trp Arg Lys 
    530                 535                 540                 


Asp Pro Val Pro Asp Leu Ala Ala Trp Val Thr Ser Phe Ala Ala Arg 
545                 550                 555                 560 


Arg Tyr Gly Val Ser His Pro Asp Ala Gly Ala Ala Trp Arg Leu Leu 
                565                 570                 575     


Leu Arg Ser Val Tyr Asn Cys Ser Gly Glu Ala Cys Arg Gly His Asn 
            580                 585                 590         


Arg Ser Pro Leu Val Arg Arg Pro Ser Leu Gln Met Asn Thr Ser Ile 
        595                 600                 605             


Trp Tyr Asn Arg Ser Asp Val Phe Glu Ala Trp Arg Leu Leu Leu Thr 
    610                 615                 620                 


Ser Ala Pro Ser Leu Ala Thr Ser Pro Ala Phe Arg Tyr Asp Leu Leu 
625                 630                 635                 640 


Asp Leu Thr Arg Gln Ala Val Gln Glu Leu Val Ser Leu Tyr Tyr Glu 
                645                 650                 655     


Glu Ala Arg Ser Ala Tyr Leu Ser Lys Glu Leu Ala Ser Leu Leu Arg 
            660                 665                 670         


Ala Gly Gly Val Leu Ala Tyr Glu Leu Leu Pro Ala Leu Asp Glu Val 
        675                 680                 685             


Leu Ala Ser Asp Ser Arg Phe Leu Leu Gly Ser Trp Leu Glu Gln Ala 
    690                 695                 700                 


Arg Ala Ala Ala Val Ser Glu Ala Glu Ala Asp Phe Tyr Glu Gln Asn 
705                 710                 715                 720 


Ser Arg Tyr Gln Leu Thr Leu Trp Gly Pro Glu Gly Asn Ile Leu Asp 
                725                 730                 735     


Tyr Ala Asn Lys Gln Leu Ala Gly Leu Val Ala Asn Tyr Tyr Thr Pro 
            740                 745                 750         


Arg Trp Arg Leu Phe Leu Glu Ala Leu Val Asp Ser Val Ala Gln Gly 
        755                 760                 765             


Ile Pro Phe Gln Gln His Gln Phe Asp Lys Asn Val Phe Gln Leu Glu 
    770                 775                 780                 


Gln Ala Phe Val Leu Ser Lys Gln Arg Tyr Pro Ser Gln Pro Arg Gly 
785                 790                 795                 800 


Asp Thr Val Asp Leu Ala Lys Lys Ile Phe Leu Lys Tyr Tyr Pro Arg 
                805                 810                 815     


Trp Val Ala Gly Ser Trp Gly Leu Glu Val Leu Phe Gln Gly Pro Glu 
            820                 825                 830         


Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
        835                 840             


<210>  60
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-101

<400>  60

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Trp Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Arg Ala Ala Ala Ser Arg Thr Leu Cys 
            20                  25                  30          


Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly 
        35                  40                  45              


Phe Leu Phe Ser Arg Gly Gly Gly Gly Ser Arg Gly Ile Leu Glu Glu 
    50                  55                  60                  


Cys Cys Phe Arg Asp Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala 
65                  70                  75                  80  


Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90                  95      


Arg Pro Arg Ala Val Pro Thr Gln Asp Pro Pro Ala Pro Leu Pro Leu 
            100                 105                 110         


Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro Leu Ser Met 
        115                 120                 125             


Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly Ile Tyr Val 
    130                 135                 140                 


Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val Glu Asn Ser 
145                 150                 155                 160 


Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys Gln Ala Leu 
                165                 170                 175     


Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met Gly Phe Ser 
            180                 185                 190         


Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys Pro Ser Pro 
        195                 200                 205             


Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln Gly Val Phe 
    210                 215                 220                 


Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys Asp Phe Ile 
225                 230                 235                 240 


Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val Gln Glu Arg 
                245                 250                 255     


Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu Asp Val Tyr 
            260                 265                 270         


Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg Gly Ile 
        275                 280                 285             


Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys Phe Val Met 
    290                 295                 300                 


Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp Ser Glu Trp 
305                 310                 315                 320 


Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile Pro Leu Gln 
                325                 330                 335     


Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys Glu Met Asp 
            340                 345                 350         


Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp His Leu Gln 
        355                 360                 365             


Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe Leu Gly 
    370                 375                 380             


<210>  61
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-104

<400>  61

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Ser Thr Ser Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                325                 330                 335     


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly 
            340                 345                 350         


Gly Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Glu Cys Asp 
        355                 360                 365             


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    370                 375                 380             


<210>  62
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-112

<400>  62

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Ala Ala Ser Arg Thr 
            20                  25                  30          


Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp 
        35                  40                  45              


Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly Gly Ser Arg Gly Ile Leu 
    50                  55                  60                  


Glu Glu Cys Cys Phe Arg Asp Cys Asp Leu Ala Leu Leu Glu Thr Tyr 
65                  70                  75                  80  


Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Asp Pro Pro Ala Pro Leu 
            100                 105                 110         


Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro Leu 
        115                 120                 125             


Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly Ile 
    130                 135                 140                 


Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val Glu 
145                 150                 155                 160 


Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys Gln 
                165                 170                 175     


Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met Gly 
            180                 185                 190         


Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys Pro 
        195                 200                 205             


Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln Gly 
    210                 215                 220                 


Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys Asp 
225                 230                 235                 240 


Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val Gln 
                245                 250                 255     


Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu Asp 
            260                 265                 270         


Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg 
        275                 280                 285             


Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys Phe 
    290                 295                 300                 


Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp Ser 
305                 310                 315                 320 


Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile Pro 
                325                 330                 335     


Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys Glu 
            340                 345                 350         


Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp His 
        355                 360                 365             


Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe Leu 
    370                 375                 380                 


Gly 
385 


<210>  63
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-114

<400>  63

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Ala Ala Ser Arg Thr 
            20                  25                  30          


Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp 
        35                  40                  45              


Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly Gly Ser Arg Gly Ile Leu 
    50                  55                  60                  


Glu Glu Cys Cys Phe Arg Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr 
65                  70                  75                  80  


Cys Ala Thr Pro Ala Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Arg Pro Arg Ala Val Pro Thr Gln Asp Pro Pro Ala Pro Leu 
            100                 105                 110         


Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro Leu 
        115                 120                 125             


Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly Ile 
    130                 135                 140                 


Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val Glu 
145                 150                 155                 160 


Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys Gln 
                165                 170                 175     


Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met Gly 
            180                 185                 190         


Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys Pro 
        195                 200                 205             


Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln Gly 
    210                 215                 220                 


Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys Asp 
225                 230                 235                 240 


Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val Gln 
                245                 250                 255     


Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu Asp 
            260                 265                 270         


Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu Arg 
        275                 280                 285             


Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys Phe 
    290                 295                 300                 


Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp Ser 
305                 310                 315                 320 


Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile Pro 
                325                 330                 335     


Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys Glu 
            340                 345                 350         


Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp His 
        355                 360                 365             


Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe Leu 
    370                 375                 380                 


Gly 
385 


<210>  64
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-115

<400>  64

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Ala Ala Asp Pro Pro 
            20                  25                  30          


Ala Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys 
        35                  40                  45              


Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile 
    50                  55                  60                  


Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu 
65                  70                  75                  80  


Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr 
                85                  90                  95      


Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn 
            100                 105                 110         


Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln 
        115                 120                 125             


Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln 
    130                 135                 140                 


His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His 
145                 150                 155                 160 


Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys 
                165                 170                 175     


Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile 
            180                 185                 190         


Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn 
        195                 200                 205             


Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu 
    210                 215                 220                 


Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro 
225                 230                 235                 240 


Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu 
                245                 250                 255     


Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly 
            260                 265                 270         


Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu 
        275                 280                 285             


Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile 
    290                 295                 300                 


Pro Phe Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Ser Thr Ser Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val 
                325                 330                 335     


Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg 
            340                 345                 350         


Gly Gly Gly Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Glu 
        355                 360                 365             


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser 
    370                 375                 380                 


Glu 
385 


<210>  65
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-116

<400>  65

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Ala Ala Asp Pro Pro 
            20                  25                  30          


Ala Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys 
        35                  40                  45              


Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile 
    50                  55                  60                  


Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu 
65                  70                  75                  80  


Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr 
                85                  90                  95      


Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn 
            100                 105                 110         


Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln 
        115                 120                 125             


Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln 
    130                 135                 140                 


His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His 
145                 150                 155                 160 


Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys 
                165                 170                 175     


Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile 
            180                 185                 190         


Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn 
        195                 200                 205             


Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu 
    210                 215                 220                 


Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro 
225                 230                 235                 240 


Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu 
                245                 250                 255     


Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly 
            260                 265                 270         


Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu 
        275                 280                 285             


Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile 
    290                 295                 300                 


Pro Phe Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Ser Gly Gly Gly Gly Ser Ser Arg Thr Leu Cys Gly Gly Glu 
                325                 330                 335     


Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe 
            340                 345                 350         


Ser Arg Gly Gly Gly Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe 
        355                 360                 365             


Arg Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    370                 375                 380                 


Arg Ser Glu 
385         


<210>  66
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-117

<400>  66

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Asp Pro Pro Ala Pro 
            20                  25                  30          


Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys Asn Pro 
        35                  40                  45              


Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile Pro Gly 
    50                  55                  60                  


Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu Asp Val 
65                  70                  75                  80  


Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr Val Cys 
                85                  90                  95      


Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn Ala Met 
            100                 105                 110         


Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln Arg Cys 
        115                 120                 125             


Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln His Gln 
    130                 135                 140                 


Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His Ile Cys 
145                 150                 155                 160 


Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys Val Val 
                165                 170                 175     


Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile Lys Glu 
            180                 185                 190         


Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn Gln Glu 
        195                 200                 205             


Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu Lys Lys 
    210                 215                 220                 


Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro Val Asp 
225                 230                 235                 240 


Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu Thr Ile 
                245                 250                 255     


Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly Leu Lys 
            260                 265                 270         


Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu Gly Asp 
        275                 280                 285             


His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile Pro Phe 
    290                 295                 300                 


Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val 
                325                 330                 335     


Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg 
            340                 345                 350         


Gly Gly Gly Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Glu 
        355                 360                 365             


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser 
    370                 375                 380                 


Glu 
385 


<210>  67
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PPT1-118

<400>  67

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Ala Ala Asp Pro Pro 
            20                  25                  30          


Ala Pro Leu Pro Leu Val Ile Trp His Gly Met Gly Asp Ser Cys Cys 
        35                  40                  45              


Asn Pro Leu Ser Met Gly Ala Ile Lys Lys Met Val Glu Lys Lys Ile 
    50                  55                  60                  


Pro Gly Ile Tyr Val Leu Ser Leu Glu Ile Gly Lys Thr Leu Met Glu 
65                  70                  75                  80  


Asp Val Glu Asn Ser Phe Phe Leu Asn Val Asn Ser Gln Val Thr Thr 
                85                  90                  95      


Val Cys Gln Ala Leu Ala Lys Asp Pro Lys Leu Gln Gln Gly Tyr Asn 
            100                 105                 110         


Ala Met Gly Phe Ser Gln Gly Gly Gln Phe Leu Arg Ala Val Ala Gln 
        115                 120                 125             


Arg Cys Pro Ser Pro Pro Met Ile Asn Leu Ile Ser Val Gly Gly Gln 
    130                 135                 140                 


His Gln Gly Val Phe Gly Leu Pro Arg Cys Pro Gly Glu Ser Ser His 
145                 150                 155                 160 


Ile Cys Asp Phe Ile Arg Lys Thr Leu Asn Ala Gly Ala Tyr Ser Lys 
                165                 170                 175     


Val Val Gln Glu Arg Leu Val Gln Ala Glu Tyr Trp His Asp Pro Ile 
            180                 185                 190         


Lys Glu Asp Val Tyr Arg Asn His Ser Ile Phe Leu Ala Asp Ile Asn 
        195                 200                 205             


Gln Glu Arg Gly Ile Asn Glu Ser Tyr Lys Lys Asn Leu Met Ala Leu 
    210                 215                 220                 


Lys Lys Phe Val Met Val Lys Phe Leu Asn Asp Ser Ile Val Asp Pro 
225                 230                 235                 240 


Val Asp Ser Glu Trp Phe Gly Phe Tyr Arg Ser Gly Gln Ala Lys Glu 
                245                 250                 255     


Thr Ile Pro Leu Gln Glu Thr Ser Leu Tyr Thr Gln Asp Arg Leu Gly 
            260                 265                 270         


Leu Lys Glu Met Asp Asn Ala Gly Gln Leu Val Phe Leu Ala Thr Glu 
        275                 280                 285             


Gly Asp His Leu Gln Leu Ser Glu Glu Trp Phe Tyr Ala His Ile Ile 
    290                 295                 300                 


Pro Phe Leu Gly Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val 
                325                 330                 335     


Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg 
            340                 345                 350         


Gly Gly Gly Gly Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Glu 
        355                 360                 365             


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser 
    370                 375                 380                 


Glu 
385 


<210>  68
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wildtype IGF2

<400>  68

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  69
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 F26S

<400>  69

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Ser Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  70
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 Y27L

<400>  70

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  71
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 V43L

<400>  71

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  72
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 F48T

<400>  72

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Thr 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  73
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 R49S

<400>  73

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Ser Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  74
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 S50I

<400>  74

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ile Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  75
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 A54R

<400>  75

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Arg Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  76
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L55R

<400>  76

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Arg Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  77
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 F26S, Y27L, V43L, F48T, R49S, S50I, A54R, L55R

<400>  77

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Ser Leu Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Thr 
        35                  40                  45              


Ser Ile Cys Asp Leu Arg Arg Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  78
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 delta 1-6, Y27L, K65R

<400>  78

Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly 
1               5                   10                  15      


Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg 
            20                  25                  30          


Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala 
        35                  40                  45              


Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60      


<210>  79
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 delta 1-7, Y27L, K65R

<400>  79

Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp 
1               5                   10                  15      


Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser 
            20                  25                  30          


Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu 
        35                  40                  45              


Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60  


<210>  80
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 delta 1-4, E6R, Y27L, K65R

<400>  80

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  81
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 delta 1-4, E6R, Y27L

<400>  81

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu 
    50                  55                  60              


<210>  82
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 E6R

<400>  82

Ala Tyr Arg Pro Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  83
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF2 delta 1-4, E6R, Y27L, S50E, K65R

<400>  83

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Glu Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  84
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable IGF2 variant-N terminal

<400>  84

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala Val Pro 
1               5                   10                  15      


Thr Gln 
        


<210>  85
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable IGF2 variant-C terminal

<400>  85

Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25  


<210>  86
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable IGF2 variant-C terminal

<400>  86

Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly Ser Gly Ser Thr 
1               5                   10                  15      


Ser Ser 
        


<210>  87
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable IGF2 variant-N terminal

<400>  87

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu Gly 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln 
    


<210>  88
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable IGF2 variant-C terminal

<400>  88

Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Thr Leu Cys Gly Gly 
            20                  25                  30          


Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Leu 
        35                  40                  45              


Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val 
    50                  55                  60                  


Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr 
65                  70                  75                  80  


Cys Ala Thr Pro Ala Arg Ser Glu 
                85              


<210>  89
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable IGF2 variant-C terminal

<400>  89

Arg Pro Arg Ala Val Pro Thr Gln Gly Gly Ser Gly Ser Gly Ser Thr 
1               5                   10                  15      


Ser Ser Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln 
            20                  25                  30          


Phe Val Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg 
        35                  40                  45              


Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Glu 
    50                  55                  60                  


Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser 
65                  70                  75                  80  


Glu 
    


<210>  90
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-1 (vIGF2_1_NGGWGMG)

<400>  90

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Asn Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Trp Cys Cys Phe Arg Gly Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Met Arg Gly Glu 
    50                  55                  60              


<210>  91
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-2 (vIGF2_2_GGWGMG)

<400>  91

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Trp Cys Cys Phe Arg Gly Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Met Arg Gly Glu 
    50                  55                  60              


<210>  92
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-3 (vIGF2_3_NGGGMG)

<400>  92

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Asn Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Gly Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Met Arg Gly Glu 
    50                  55                  60              


<210>  93
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-4 (vIGF2_4_delta 32-41, 53aa)

<400>  93

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ile Val Glu Glu Cys 
            20                  25                  30          


Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr 
        35                  40                  45              


Pro Ala Arg Ser Glu 
    50              


<210>  94
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-5 (vIGF2 delta 30-39, 53aa)

<400>  94

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Ile Val Glu Glu Cys 
            20                  25                  30          


Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr 
        35                  40                  45              


Pro Ala Arg Ser Glu 
    50              


<210>  95
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-6 (vIGF2 delta 33-40, 55aa)

<400>  95

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Gly Ile Val Glu 
            20                  25                  30          


Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys 
        35                  40                  45              


Ala Thr Pro Ala Arg Ser Glu 
    50                  55  


<210>  96
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-7 (vIGF2 delta 30-39/V14D/F28R/V43D/F26A)

<400>  96

Ser Arg Thr Leu Cys Gly Gly Glu Leu Asp Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Ala Leu Arg Ser Arg Gly Ile Asp Glu Glu Cys 
            20                  25                  30          


Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr 
        35                  40                  45              


Pro Ala Arg Ser Glu 
    50              


<210>  97
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-8 (vIGF2_8_REE)

<400>  97

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Arg Arg Gly Glu Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Glu Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  98
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-9 (vIGF2_9_ delta 30-39-REE; vIGF2)

<400>  98

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Arg Arg Gly Glu Leu Phe Ser Arg Pro Ala Gly Ile Val Glu 
            20                  25                  30          


Glu Cys Cys Phe Arg Glu Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys 
        35                  40                  45              


Ala Thr Pro Ala Arg Ser Glu 
    50                  55  


<210>  99
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-10 (vIGF2_1Q; vIGF2 D23R)

<400>  99

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Arg Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  100
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-11 (vIGF2_2Q; vIGF2 F19W)

<400>  100

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Trp Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  101
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-12 (vIGF2_3Q; vIGF2 T16W)

<400>  101

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Trp Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  102
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-13 (vIGF2_4Q; vIGF2 D23K)

<400>  102

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Lys Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  103
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-14 (vIGF2_5Q; vIGF2 T16Y)

<400>  103

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Tyr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  104
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-15 (vIGF2_6Q; vIGF2 F26E)

<400>  104

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Glu Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  105
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-16 (vIGF2_7Q; vIGF2 T16V)

<400>  105

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Val Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  106
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-17 (vIGF2_8Q; vIGF2 S50E)

<400>  106

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Glu Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  107
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-18 (vIGF2_9Q; vIGF2 S50D)

<400>  107

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Asp Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  108
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-19 (vIGF2 F26S V43L)

<400>  108

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Ser Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  109
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-20 (vIGF2 V43L)

<400>  109

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  110
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-21 (vIGF2_ESRE; vIGF2 V14E F26S F28R V43E)

<400>  110

Ser Arg Thr Leu Cys Gly Gly Glu Leu Glu Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Ser Leu Arg Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Glu Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  111
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-22 (vIGF2 delta 31-38GGGG)

<400>  111

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly Gly Ser Arg 
            20                  25                  30          


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
        35                  40                  45              


Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  


<210>  112
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-23 (vIGF2 delta 30-40GGGG)

<400>  112

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Gly Gly Gly Ser Gly Ile Val 
            20                  25                  30          


Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr 
        35                  40                  45              


Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55      


<210>  113
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-24 (vIGF2 delta 31-38GGGG V43L)

<400>  113

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly Gly Ser Arg 
            20                  25                  30          


Gly Ile Leu Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
        35                  40                  45              


Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  


<210>  114
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-25 (vIGF2 L8A)

<400>  114

Ser Arg Thr Ala Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  115
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-26 (vIGF2 R6Q T7A L8A)

<400>  115

Ser Gln Ala Ala Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  116
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-27 (vIGF2 R24E R34E R37E R38E)

<400>  116

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Glu Gly Phe Leu Phe Ser Arg Pro Ala Ser Glu Val Ser 
            20                  25                  30          


Glu Glu Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  117
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-28 (vIGF2 R24E R34E)

<400>  117

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Glu Gly Phe Leu Phe Ser Arg Pro Ala Ser Glu Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  118
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-29 (vIGF2 D23R S40D)

<400>  118

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Arg Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Asp Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  119
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-30 (vIGF2 T16V D23R S50D)

<400>  119

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Val Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Arg Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Asp Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  120
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-31 (vIGF2 delta 31-38GGGG V43L S50D)

<400>  120

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly Gly Ser Arg 
            20                  25                  30          


Gly Ile Leu Glu Glu Cys Cys Phe Arg Asp Cys Asp Leu Ala Leu Leu 
        35                  40                  45              


Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  


<210>  121
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-32 (vIGF2 delta 31-38GGGG V43L S50E)

<400>  121

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Gly Gly Gly Ser Arg 
            20                  25                  30          


Gly Ile Leu Glu Glu Cys Cys Phe Arg Glu Cys Asp Leu Ala Leu Leu 
        35                  40                  45              


Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  


<210>  122
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-33 (vIGF2-N1)

<400>  122

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Arg Leu Pro Ser Arg Pro Val Ser 
            20                  25                  30          


Arg His Ser His Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Gln Arg Cys Asn Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Arg Ser Glu 
65          


<210>  123
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-34 (vIGF2-N1 V43L S50E)

<400>  123

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Arg Leu Pro Ser Arg Pro Val Ser 
            20                  25                  30          


Arg His Ser His Arg Arg Ser Arg Gly Ile Leu Glu Glu Cys Cys Phe 
        35                  40                  45              


Gln Glu Cys Asn Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Arg Ser Glu 
65          


<210>  124
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-1 R38G

<400>  124

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  125
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-2 R38G, E45W

<400>  125

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Trp Cys Cys Phe Arg Ser Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  126
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-3 R38G, E45W, S50G

<400>  126

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Pro Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Trp Cys Cys Phe Arg Gly Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  127
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-4 P31G, R38G, E45W, S50G

<400>  127

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Trp Cys Cys Phe Arg Gly Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  128
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-5 L17N, P31G, R38G, E45W, S50G

<400>  128

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Asn Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Trp Cys Cys Phe Arg Gly Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Ser Glu 
    50                  55                  60              


<210>  129
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-6 L17N, P31G, R38G, E45W, S50G, S66G

<400>  129

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Asn Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Trp Cys Cys Phe Arg Gly Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala Arg Gly Glu 
    50                  55                  60              


<210>  130
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-7 L17N, P31G, R38G, E45W, S50G, A64M, S66G

<400>  130

Ser Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Asn Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Trp Cys Cys Phe Arg Gly Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Met Arg Gly Glu 
    50                  55                  60              


<210>  131
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vIGF2-8 S5L, L17N, P31G, R38G, E45W, S50G, A64M, S66G

<400>  131

Leu Arg Thr Leu Cys Gly Gly Glu Leu Val Asp Thr Asn Gln Phe Val 
1               5                   10                  15      


Cys Gly Asp Arg Gly Phe Leu Phe Ser Arg Gly Ala Ser Arg Val Ser 
            20                  25                  30          


Arg Gly Ser Arg Gly Ile Val Glu Trp Cys Cys Phe Arg Gly Cys Asp 
        35                  40                  45              


Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Met Arg Gly Glu 
    50                  55                  60              


<210>  132
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mature WT IGF2

<400>  132
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagccg tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga gacgtactgt      180

gctacccccg ccaagtccga g                                                201


<210>  133
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2 delta 1-4, E6R, Y27L, K65R

<400>  133
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  134
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2 delta 1-4, E6R, Y27L, S50E, K65R

<400>  134
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcagggagtg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  135
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-1 (vIGF2_1_NGGWGMG)

<400>  135
tctagaacac tgtgcggagg ggagcttgta gacactaacc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgcgg cgcttccaga gtttcacggg gctctagggg tatagtagag      120

tggtgttgtt tcaggggctg tgacttggcg ctcctcgaga cctattgcgc gacgccaatg      180

aggggcgaa                                                              189


<210>  136
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-2 (vIGF2_2_GGWGMG)

<400>  136
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgcgg cgcttccaga gtttcacggg gctctagggg tatagtagag      120

tggtgttgtt tcaggggctg tgacttggcg ctcctcgaga cctattgcgc gacgccaatg      180

aggggcgaa                                                              189


<210>  137
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-3 (vIGF2_3_NGGGMG)

<400>  137
tctagaacac tgtgcggagg ggagcttgta gacactaacc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgcgg cgcttccaga gtttcacggg gctctagggg tatagtagag      120

gagtgttgtt tcaggggctg tgacttggcg ctcctcgaga cctattgcgc gacgccaatg      180

aggggcgaa                                                              189


<210>  138
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-4 (vIGF2_4_delta 32-41, 53aa)

<400>  138
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc catagtagag gagtgttgtt tcaggtcctg tgacttggcg      120

ctcctcgaga cctattgcgc gacgccagcc aggtccgaa                             159


<210>  139
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-5 (vIGF2 delta 30-39, 53aa)

<400>  139
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctagggg tatagtagag gagtgttgtt tcaggtcctg tgacttggcg      120

ctcctcgaga cctattgcgc gacgccagcc aggtccgaa                             159


<210>  140
<211>  165
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-6 (vIGF2 delta 33-40, 55aa)

<400>  140
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgctggtata gtagaggagt gttgtttcag gtcctgtgac      120

ttggcgctcc tcgagaccta ttgcgcgacg ccagccaggt ccgaa                      165


<210>  141
<211>  159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-7 (vIGF2 delta 30-39/V14D/F28R/V43D/F26A)

<400>  141
tctagaacac tgtgcggagg ggagcttgac gacactcttc agttcgtgtg tggagatcgc       60

ggggccctca gatctagggg tatagacgag gagtgttgtt tcaggtcctg tgacttggcg      120

ctcctcgaga cctattgcgc gacgccagcc aggtccgaa                             159


<210>  142
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-8 (vIGF2_8_REE)

<400>  142
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggaagacgc       60

ggggagctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcagggagtg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  143
<211>  165
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-9 (vIGF2_9_ delta 30-39-REE; vIGF2 Homerun)

<400>  143
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggaagacgc       60

ggggagctct tctctcgccc cgctggtata gtagaggagt gttgtttcag ggagtgtgac      120

ttggcgctcc tcgagaccta ttgcgcgacg ccagccaggt ccgaa                      165


<210>  144
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-10 (vIGF2_1Q; vIGF2 D23R)

<400>  144
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggacgtcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  145
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-11 (vIGF2_2Q; vIGF2 F19W)

<400>  145
tctagaacac tgtgcggagg ggagcttgta gacactcttc agtgggtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  146
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-12 (vIGF2_3Q; vIGF2 T16W)

<400>  146
tctagaacac tgtgcggagg ggagcttgta gactggcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  147
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-13 (vIGF2_4Q; vIGF2 D23K)

<400>  147
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggaaagcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  148
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-14 (vIGF2_5Q; vIGF2 T16Y)

<400>  148
tctagaacac tgtgcggagg ggagcttgta gactatcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  149
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-15 (vIGF2_6Q; vIGF2 F26E)

<400>  149
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

ggggagctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  150
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-16 (vIGF2_7Q; vIGF2 T16V)

<400>  150
tctagaacac tgtgcggagg ggagcttgta gacgttcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  151
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-17 (vIGF2_8Q; vIGF2 S50E)

<400>  151
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcagggagtg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  152
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-18 (vIGF2_9Q; vIGF2 S50D)

<400>  152
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcagggactg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  153
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-19 (vIGF2 F26S V43L)

<400>  153
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggagcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatactggag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  154
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-20 (vIGF2 V43L)

<400>  154
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatactggag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  155
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-21 (vIGF2_ESRE; vIGF2 V14E F26S F28R V43E)

<400>  155
tctagaacac tgtgcggagg ggagcttgag gacactcttc agttcgtgtg tggagatcgc       60

gggagcctca gatctcgccc cgcttccaga gtttcacgga ggtctagggg tatagaggag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  156
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-22 (vIGF2 delta 31-38GGGG)

<400>  156
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgcgg aggtggaggt tctaggggta tagtagagga gtgttgtttc      120

aggtcctgtg acttggcgct cctcgagacc tattgcgcga cgccagccag gtccgaa         177


<210>  157
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-23 (vIGF2 delta 30-40GGGG)

<400>  157
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctggtgg aggttctggt atagtagagg agtgttgttt caggtcctgt      120

gacttggcgc tcctcgagac ctattgcgcg acgccagcca ggtccgaa                   168


<210>  158
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-24 (vIGF2 delta 31-38GGGG V43L)

<400>  158
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgcgg aggtggaggt tctaggggta tactggagga gtgttgtttc      120

aggtcctgtg acttggcgct cctcgagacc tattgcgcga cgccagccag gtccgaa         177


<210>  159
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-25 (vIGF2 L8A)

<400>  159
tctcaggccg cgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  160
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-26 (vIGF2 R6Q T7A L8A)

<400>  160
tctcaggccg cgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  161
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-27 (vIGF2 R24E R34E R37E R38E)

<400>  161
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatgag       60

gggttcctct tctctcgccc cgcttccgag gtttcagagg aatctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  162
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-28 (vIGF2 R24E R34E)

<400>  162
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatgag       60

gggttcctct tctctcgccc cgcttccgag gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcaggtcctg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  163
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-29 (vIGF2 D23R S40D)

<400>  163
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggaagacgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcagggactg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  164
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-30 (vIGF2 T16V D23R S50D)

<400>  164
tctagaacac tgtgcggagg ggagcttgta gacgtgcttc agttcgtgtg tggaagacgc       60

gggttcctct tctctcgccc cgcttccaga gtttcacgga ggtctagggg tatagtagag      120

gagtgttgtt tcagggactg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc      180

aggtccgaa                                                              189


<210>  165
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-31 (vIGF2 delta 31-38GGGG V43L S50D)

<400>  165
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgcgg aggtggaggt tctaggggta tactggagga gtgttgtttc      120

agggactgtg acttggcgct cctcgagacc tattgcgcga cgccagccag gtccgaa         177


<210>  166
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-32 (vIGF2 delta 31-38GGGG V43L S50E)

<400>  166
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcctct tctctcgcgg aggtggaggt tctaggggta tactggagga gtgttgtttc      120

agggagtgtg acttggcgct cctcgagacc tattgcgcga cgccagccag gtccgaa         177


<210>  167
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-33 (vIGF2-N1)

<400>  167
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcttgt ttcgattgcc gtccaggccc gtgtcccggc acagtcaccg caggtcaagg      120

gggatagttg aagaatgttg ctttcagagg tgtaatttgg cgctcctcga gacctattgc      180

gcgacgccag ccaggtccga a                                                201


<210>  168
<211>  201
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-34 (vIGF2-N1 V43L S50E)

<400>  168
tctagaacac tgtgcggagg ggagcttgta gacactcttc agttcgtgtg tggagatcgc       60

gggttcttgt ttcgattgcc gtccaggccc gtgtcccggc acagtcaccg caggtcaagg      120

gggatactgg aagaatgttg ctttcaggag tgtaatttgg cgctcctcga gacctattgc      180

gcgacgccag ccaggtccga a                                                201


<210>  169
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native human BiP

<400>  169

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala 
        


<210>  170
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified BiP-1

<400>  170

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Ala Met Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25              


<210>  171
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified BiP-2

<400>  171

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Trp Val Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25  


<210>  172
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified BiP-3

<400>  172

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Leu Val 
1               5                   10                  15      


Ala Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25      


<210>  173
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Modified BiP-4

<400>  173

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ala Leu Val 
1               5                   10                  15      


Ala Leu Leu Leu Leu Ser Ala Ala Arg Ala 
            20                  25      


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gaussia

<400>  174

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  175
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native PPT1 Signal Peptide (eSP)

<400>  175

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu 
            20                  25          


<210>  176
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native PPT1 Signal Peptide (eSP AA)

<400>  176

Met Ala Ser Pro Gly Cys Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Ala Ala 
            20                  25                  


<210>  177
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native PPT1 Signal Peptide C6S (eSP C6S)

<400>  177

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu 
            20                  25          


<210>  178
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native PPT1 Signal Peptide C6S (eSP C6S AA)

<400>  178

Met Ala Ser Pro Gly Ser Leu Trp Leu Leu Ala Val Ala Leu Leu Pro 
1               5                   10                  15      


Trp Thr Cys Ala Ser Arg Ala Leu Gln His Leu Ala Ala 
            20                  25                  


<210>  179
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native TPP1 Signal Peptide

<400>  179

Met Gly Leu Gln Ala Cys Leu Leu Gly Leu Phe Ala Leu Ile Leu Ser 
1               5                   10                  15      


Gly Lys Cys 
            


<210>  180
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native NAGLU Signal Peptide

<400>  180

Met Glu Ala Val Ala Val Ala Ala Ala Val Gly Val Leu Leu Leu Ala 
1               5                   10                  15      


Gly Ala Gly Gly Ala Ala Gly Asp 
            20                  


<210>  181
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  181

Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   


<210>  182
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  182

Gly Gly Gly Gly Ser 
1               5   


<210>  183
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  183

Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  184
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  184

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  185
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  185

Gly Gly Ser Gly Ser Gly Ser Thr Ser 
1               5                   


<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  186

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  187
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker Sequence

<400>  187

Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lysosomal cleaveage linker

<400>  188

Arg Pro Arg Ala Val Pro Thr Gln Ala 
1               5                   


<210>  189
<211>  2864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak- hGAA (Natural GAA)

<400>  189
gcaagatggg agtgaggcac ccgccctgct cccaccggct cctggccgtc tgcgccctcg       60

tgtccttggc aaccgctgca ctcctggggc acatcctact ccatgatttc ctgctggttc      120

cccgagagct gagtggctcc tccccagtcc tggaggagac tcacccagct caccagcagg      180

gagccagtag accagggccc cgggatgccc aggcacaccc cggccgtccc agagcagtgc      240

ccacacagtg cgacgtcccc cccaacagcc gcttcgattg cgcccctgac aaggccatca      300

cccaggaaca gtgcgaggcc cgcggctgtt gctacatccc tgcaaagcag gggctgcagg      360

gagcccagat ggggcagccc tggtgcttct tcccacccag ctaccccagc tacaagctgg      420

agaacctgag ctcctctgaa atgggctaca cggccaccct gacccgtacc acccccacct      480

tcttccccaa ggacatcctg accctgcggc tggacgtgat gatggagact gagaaccgcc      540

tccacttcac gatcaaagat ccagctaaca ggcgctacga ggtgcccttg gagaccccgc      600

atgtccacag ccgggcaccg tccccactct acagcgtgga gttctccgag gagcccttcg      660

gggtgatcgt gcgccggcag ctggacggcc gcgtgctgct gaacacgacg gtggcgcccc      720

tgttctttgc ggaccagttc cttcagctgt ccacctcgct gccctcgcag tatatcacag      780

gcctcgccga gcacctcagt cccctgatgc tcagcaccag ctggaccagg atcaccctgt      840

ggaaccggga ccttgcgccc acgcccggtg cgaacctcta cgggtctcac cctttctacc      900

tggcgctgga ggacggcggg tcggcacacg gggtgttcct gctaaacagc aatgccatgg      960

atgtggtcct gcagccgagc cctgccctta gctggaggtc gacaggtggg atcctggatg     1020

tctacatctt cctgggccca gagcccaaga gcgtggtgca gcagtacctg gacgttgtgg     1080

gatacccgtt catgccgcca tactggggcc tgggcttcca cctgtgccgc tggggctact     1140

cctccaccgc tatcacccgc caggtggtgg agaacatgac cagggcccac ttccccctgg     1200

acgtccagtg gaacgacctg gactacatgg actcccggag ggacttcacg ttcaacaagg     1260

atggcttccg ggacttcccg gccatggtgc aggagctgca ccagggcggc cggcgctaca     1320

tgatgatcgt ggatcctgcc atcagcagct cgggccctgc cgggagctac aggccctacg     1380

acgagggtct gcggaggggg gttttcatca ccaacgagac cggccagccg ctgattggga     1440

aggtatggcc cgggtccact gccttccccg acttcaccaa ccccacagcc ctggcctggt     1500

gggaggacat ggtggctgag ttccatgacc aggtgccctt cgacggcatg tggattgaca     1560

tgaacgagcc ttccaacttc atcaggggct ctgaggacgg ctgccccaac aatgagctgg     1620

agaacccacc ctacgtgcct ggggtggttg gggggaccct ccaggcggcc accatctgtg     1680

cctccagcca ccagtttctc tccacacact acaacctgca caacctctac ggcctgaccg     1740

aagccatcgc ctcccacagg gcgctggtga aggctcgggg gacacgccca tttgtgatct     1800

cccgctcgac ctttgctggc cacggccgat acgccggcca ctggacgggg gacgtgtgga     1860

gctcctggga gcagctcgcc tcctccgtgc cagaaatcct gcagtttaac ctgctggggg     1920

tgcctctggt cggggccgac gtctgcggct tcctgggcaa cacctcagag gagctgtgtg     1980

tgcgctggac ccagctgggg gccttctacc ccttcatgcg gaaccacaac agcctgctca     2040

gtctgcccca ggagccgtac agcttcagcg agccggccca gcaggccatg aggaaggccc     2100

tcaccctgcg ctacgcactc ctcccccacc tctacacact gttccaccag gcccacgtcg     2160

cgggggagac cgtggcccgg cccctcttcc tggagttccc caaggactct agcacctgga     2220

ctgtggacca ccagctcctg tggggggagg ccctgctcat caccccagtg ctccaggccg     2280

ggaaggccga agtgactggc tacttcccct tgggcacatg gtacgacctg cagacggtgc     2340

cagtagaggc ccttggcagc ctcccacccc cacctgcagc tccccgtgag ccagccatcc     2400

acagcgaggg gcagtgggtg acgctgccgg cccccctgga caccatcaac gtccacctcc     2460

gggctgggta catcatcccc ctgcagggcc ctggcctcac aaccacagag tcccgccagc     2520

agcccatggc cctggctgtg gccctgacca agggtgggga ggcccgaggg gagcttttct     2580

gggacgatgg agagagcctg gaagtgctgg agcgaggggc ctacacacag gtcatcttcc     2640

tggccaggaa taacacgatc gtgaatgagc tggtacgtgt gaccagtgag ggagctggcc     2700

tgcagctgca gaaggtgact gtcctgggcg tggccacggc gccccagcag gtcctctcca     2760

acggtgtccc tgtctccaac ttcacctaca gccccgacac caaggtcctg gacatctgtg     2820

tctcgctgtt gatgggagag cagtttctcg tcagctggtg ttag                      2864


<210>  190
<211>  2954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak BiP-vIGF2-GAA (Engineered hGAA)

<400>  190
gcaagatgaa gctctccctg gtggccgcga tgctgctgct gctcagcgcg gcgcgggcct       60

ctagaacact gtgcggaggg gagcttgtag acactcttca gttcgtgtgt ggagatcgcg      120

ggttcctctt ctctcgcccc gcttccagag tttcacggag gtctaggggt atagtagagg      180

agtgttgttt caggtcctgt gacttggcgc tcctcgagac ctattgcgcg acgccagcca      240

ggtccgaagg gggcggtggc tcaggtggtg gaggtagcag accagggccc cgggatgccc      300

aggcacaccc cggccgtccc agagcagtgc ccacacagtg cgacgtcccc cccaacagcc      360

gcttcgattg cgcccctgac aaggccatca cccaggaaca gtgcgaggcc cgcggctgtt      420

gctacatccc tgcaaagcag gggctgcagg gagcccagat ggggcagccc tggtgcttct      480

tcccacccag ctaccccagc tacaagctgg agaacctgag ctcctctgaa atgggctaca      540

cggccaccct gacccgtacc acccccacct tcttccccaa ggacatcctg accctgcggc      600

tggacgtgat gatggagact gagaaccgcc tccacttcac gatcaaagat ccagctaaca      660

ggcgctacga ggtgcccttg gagaccccgc atgtccacag ccgggcaccg tccccactct      720

acagcgtgga gttctccgag gagcccttcg gggtgatcgt gcgccggcag ctggacggcc      780

gcgtgctgct gaacacgacg gtggcgcccc tgttctttgc ggaccagttc cttcagctgt      840

ccacctcgct gccctcgcag tatatcaccg gcctcgccga gcacctcagt cccctgatgc      900

tcagcaccag ctggaccagg atcaccctgt ggaaccggga ccttgcgccc acgcccggtg      960

cgaacctcta cgggtctcac cctttctacc tggcgctgga ggacggcggg tcggcacacg     1020

gggtgttcct gctaaacagc aatgccatgg atgtggtcct gcagccgagc cctgccctta     1080

gctggaggtc gacaggtggg atcctggatg tctacatctt cctgggccca gagcccaaga     1140

gcgtggtgca gcagtacctg gacgttgtgg gatacccgtt catgccgcca tactggggcc     1200

tgggcttcca cctgtgccgc tggggctact cctccaccgc tatcacccgc caggtggtgg     1260

agaacatgac cagggcccac ttccccctgg acgtccagtg gaacgacctg gactacatgg     1320

actcccggag ggacttcacg ttcaacaagg atggcttccg ggacttcccg gccatggtgc     1380

aggagctgca ccagggcggc cggcgctaca tgatgatcgt ggatcctgcc atcagcagct     1440

cgggccctgc cgggagctac aggccctacg acgagggtct gcggaggggg gttttcatca     1500

ccaacgagac cggccagccg ctgattggga aggtatggcc cgggtccact gccttccccg     1560

acttcaccaa ccccacagcc ctggcctggt gggaggacat ggtggctgag ttccatgacc     1620

aggtgccctt cgacggcatg tggattgaca tgaacgagcc ttccaacttc atcaggggct     1680

ctgaggacgg ctgccccaac aatgagctgg agaacccacc ctacgtgcct ggggtggttg     1740

gggggaccct ccaggcggcc accatctgtg cctccagcca ccagtttctc tccacacact     1800

acaacctgca caacctctac ggcctgaccg aagccatcgc ctcccacagg gcgctggtga     1860

aggctcgggg gacacgccca tttgtgatct cccgctcgac ctttgctggc cacggccgat     1920

acgccggcca ctggacgggg gacgtgtgga gctcctggga gcagctcgcc tcctccgtgc     1980

cagaaatcct gcagtttaac ctgctggggg tgcctctggt cggggccgac gtctgcggct     2040

tcctgggcaa cacctcagag gagctgtgtg tgcgctggac ccagctgggg gccttctacc     2100

ccttcatgcg gaaccacaac agcctgctca gtctgcccca ggagccgtac agcttcagcg     2160

agccggccca gcaggccatg aggaaggccc tcaccctgcg ctacgcactc ctcccccacc     2220

tctacacact gttccaccag gcccacgtcg cgggggagac cgtggcccgg cccctcttcc     2280

tggagttccc caaggactct agcacctgga ctgtggacca ccagctcctg tggggggagg     2340

ccctgctcat caccccagtg ctccaggccg ggaaggccga agtgactggc tacttcccct     2400

tgggcacatg gtacgacctg cagacggtgc cagtagaggc ccttggcagc ctcccacccc     2460

cacctgcagc tccccgtgag ccagccatcc acagcgaggg gcagtgggtg acgctgccgg     2520

cccccctgga caccatcaac gtccacctcc gggctgggta catcatcccc ctgcagggcc     2580

ctggcctcac aaccacagag tcccgccagc agcccatggc cctggctgtg gccctgacca     2640

agggtgggga ggcccgaggg gagctgttct gggacgatgg agagagcctg gaagtgctgg     2700

agcgaggggc ctacacacag gtcatcttcc tggccaggaa taacacgatc gtgaatgagc     2760

tggtacgtgt gaccagtgag ggagctggcc tgcagctgca gaaggtgact gtcctgggcg     2820

tggccacggc gccccagcag gtcctctcca acggtgtccc tgtctccaac ttcacctaca     2880

gccccgacac caaggtcctg gacatctgtg tctcgctgtt gatgggagag cagtttctcg     2940

tcagctggtg ttag                                                       2954


<210>  191
<211>  3139
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cricket Paralysis Virus IRES -BiP-vIGF2-GAA

<400>  191
aaaaatgtga tcttgcttgt aaatacaatt ttgagaggtt aataaattac aagtagtgct       60

atttttgtat ttaggttagc tatttagctt tacgttccag gatgcctagt ggcagcccca      120

caatatccag gaagccctct ctgcggtttt tcagattagg tagtcgaaaa acctaagaaa      180

tttacctgct atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg      240

ggcctctaga acactgtgcg gaggggagct tgtagacact cttcagttcg tgtgtggaga      300

tcgcgggttc ctcttctctc gccccgcttc cagagtttca cggaggtcta ggggtatagt      360

agaggagtgt tgtttcaggt cctgtgactt ggcgctcctc gagacctatt gcgcgacgcc      420

agccaggtcc gaagggggcg gtggctcagg tggtggaggt agcagaccag ggccccggga      480

tgcccaggca caccccggcc gtcccagagc agtgcccaca cagtgcgacg tcccccccaa      540

cagccgcttc gattgcgccc ctgacaaggc catcacccag gaacagtgcg aggcccgcgg      600

ctgttgctac atccctgcaa agcaggggct gcagggagcc cagatggggc agccctggtg      660

cttcttccca cccagctacc ccagctacaa gctggagaac ctgagctcct ctgaaatggg      720

ctacacggcc accctgaccc gtaccacccc caccttcttc cccaaggaca tcctgaccct      780

gcggctggac gtgatgatgg agactgagaa ccgcctccac ttcacgatca aagatccagc      840

taacaggcgc tacgaggtgc ccttggagac cccgcatgtc cacagccggg caccgtcccc      900

actctacagc gtggagttct ccgaggagcc cttcggggtg atcgtgcgcc ggcagctgga      960

cggccgcgtg ctgctgaaca cgacggtggc gcccctgttc tttgcggacc agttccttca     1020

gctgtccacc tcgctgccct cgcagtatat cacaggcctc gccgagcacc tcagtcccct     1080

gatgctcagc accagctgga ccaggatcac cctgtggaac cgggaccttg cgcccacgcc     1140

cggtgcgaac ctctacgggt ctcacccttt ctacctggcg ctggaggacg gcgggtcggc     1200

acacggggtg ttcctgctaa acagcaatgc catggatgtg gtcctgcagc cgagccctgc     1260

ccttagctgg aggtcgacag gtgggatcct ggatgtctac atcttcctgg gcccagagcc     1320

caagagcgtg gtgcagcagt acctggacgt tgtgggatac ccgttcatgc cgccatactg     1380

gggcctgggc ttccacctgt gccgctgggg ctactcctcc accgctatca cccgccaggt     1440

ggtggagaac atgaccaggg cccacttccc cctggacgtc cagtggaacg acctggacta     1500

catggactcc cggagggact tcacgttcaa caaggatggc ttccgggact tcccggccat     1560

ggtgcaggag ctgcaccagg gcggccggcg ctacatgatg atcgtggatc ctgccatcag     1620

cagctcgggc cctgccggga gctacaggcc ctacgacgag ggtctgcgga ggggggtttt     1680

catcaccaac gagaccggcc agccgctgat tgggaaggta tggcccgggt ccactgcctt     1740

ccccgacttc accaacccca cagccctggc ctggtgggag gacatggtgg ctgagttcca     1800

tgaccaggtg cccttcgacg gcatgtggat tgacatgaac gagccttcca acttcatcag     1860

gggctctgag gacggctgcc ccaacaatga gctggagaac ccaccctacg tgcctggggt     1920

ggttgggggg accctccagg cggccaccat ctgtgcctcc agccaccagt ttctctccac     1980

acactacaac ctgcacaacc tctacggcct gaccgaagcc atcgcctccc acagggcgct     2040

ggtgaaggct cgggggacac gcccatttgt gatctcccgc tcgacctttg ctggccacgg     2100

ccgatacgcc ggccactgga cgggggacgt gtggagctcc tgggagcagc tcgcctcctc     2160

cgtgccagaa atcctgcagt ttaacctgct gggggtgcct ctggtcgggg ccgacgtctg     2220

cggcttcctg ggcaacacct cagaggagct gtgtgtgcgc tggacccagc tgggggcctt     2280

ctaccccttc atgcggaacc acaacagcct gctcagtctg ccccaggagc cgtacagctt     2340

cagcgagccg gcccagcagg ccatgaggaa ggccctcacc ctgcgctacg cactcctccc     2400

ccacctctac acactgttcc accaggccca cgtcgcgggg gagaccgtgg cccggcccct     2460

cttcctggag ttccccaagg actctagcac ctggactgtg gaccaccagc tcctgtgggg     2520

ggaggccctg ctcatcaccc cagtgctcca ggccgggaag gccgaagtga ctggctactt     2580

ccccttgggc acatggtacg acctgcagac ggtgccagta gaggcccttg gcagcctccc     2640

acccccacct gcagctcccc gtgagccagc catccacagc gaggggcagt gggtgacgct     2700

gccggccccc ctggacacca tcaacgtcca cctccgggct gggtacatca tccccctgca     2760

gggccctggc ctcacaacca cagagtcccg ccagcagccc atggccctgg ctgtggccct     2820

gaccaagggt ggggaggccc gaggggagct gttctgggac gatggagaga gcctggaagt     2880

gctggagcga ggggcctaca cacaggtcat cttcctggcc aggaataaca cgatcgtgaa     2940

tgagctggta cgtgtgacca gtgagggagc tggcctgcag ctgcagaagg tgactgtcct     3000

gggcgtggcc acggcgcccc agcaggtcct ctccaacggt gtccctgtct ccaacttcac     3060

ctacagcccc gacaccaagg tcctggacat ctgtgtctcg ctgttgatgg gagagcagtt     3120

tctcgtcagc tggtgttag                                                  3139


<210>  192
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wt-PPT1 IDT codon optimized

<400>  192
atggcatcac cgggttgcct ctggttgttg gccgttgcgt tgcttccgtg gacatgtgca       60

tcaagagctc ttcaacatct ggatccccca gctcccctgc cgctcgtaat ctggcacggg      120

atgggggatt catgttgtaa cccgttgtca atgggcgcga taaaaaagat ggttgaaaag      180

aagattccag gcatctacgt tctgtccctg gaaatcggta agacactgat ggaagacgtg      240

gagaactcct tctttctcaa cgtcaatagt caggtcacta ccgtctgtca agcattggca      300

aaggacccta aacttcagca ggggtacaat gcgatggggt ttagccaggg cggacagttt      360

cttagagccg tcgcacagcg ctgtccatct cccccgatga ttaaccttat atctgtcggg      420

ggacaacacc agggtgtttt tggtcttcct cgctgtcctg gtgaaagctc ccacatctgt      480

gatttcatac gcaaaacgtt gaacgcagga gcttatagta aagtcgtcca agaacggctt      540

gttcaagcgg agtattggca tgacccaata aaagaagacg tttataggaa tcactctatc      600

ttcttggccg atatcaacca agaacgcgga atcaacgaaa gctacaaaaa gaatcttatg      660

gctctcaaga aatttgttat ggtgaaattc cttaatgact ctatagtaga tcctgtcgat      720

tcagaatggt tcgggttcta caggtctggc caggcgaagg agactattcc cctccaagaa      780

acgtctctct atacacaaga cagactcgga ctgaaagaga tggataatgc gggccagttg      840

gtcttcttgg ctacggaagg cgatcatctc caactctccg aagagtggtt ctatgcccat      900

ataatcccgt tcctgggcta a                                                921


<210>  193
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-2 (wt-vIGF2-PPT1; Codon optimized by IDT codon optimization 
       tool)

<400>  193
atggcatccc ccggatgttt gtggctgctg gcggttgcgc ttctgccatg gacgtgcgcc       60

tcccgagccc tccaacacct gtccaggaca ctttgcggcg gagagttggt cgatacgctt      120

caattcgtgt gtggggatag aggcttcctt ttttctcggc ccgctagccg cgtgtcccga      180

aggtcccggg gtatcgttga ggaatgctgt ttccggtcct gcgatcttgc actgttggag      240

acatactgtg ctacgcctgc gagaagcgag ggtggagggg gttctggagg tggagggagc      300

cggcctcggg cggttcccac ccaggatcct ccagctcctc tgcctctggt catctggcat      360

gggatggggg actcatgttg taacccgctg agtatggggg caattaaaaa aatggttgaa      420

aagaaaattc caggtattta tgtcctctct cttgaaatcg gtaagacact tatggaggat      480

gtggaaaact cctttttcct taatgtcaat tctcaggtca caacagtttg tcaggctctg      540

gcgaaggatc ctaagctgca gcaaggctac aacgccatgg gtttttccca gggaggccaa      600

tttctcagag cggtagctca gcgatgtcca tcaccaccga tgataaatct gatcagtgtc      660

ggcggacaac accagggagt tttcgggctg cccaggtgtc cgggggaatc tagtcacata      720

tgtgacttca ttcgcaagac ccttaacgcc ggcgcttact caaaggtggt tcaagaacgg      780

cttgtgcagg ctgaatactg gcacgatccc atcaaggaag atgtatatag gaaccacagt      840

atctttctgg cagacataaa tcaggaaagg ggtattaacg aaagctacaa gaaaaatctc      900

atggccctga agaaatttgt aatggttaag tttttgaacg attctatagt agatcctgtt      960

gactccgagt ggttcgggtt ctatcgatct ggtcaagcca aggagacgat tccgcttcag     1020

gaaacttcac tgtacacaca ggatcggctg ggactcaagg agatggacaa tgcgggccag     1080

ttggtgtttc tggctacaga gggagaccat ctccagttga gtgaagaatg gttctatgca     1140

catattatcc cattcctcgg ctaa                                            1164


<210>  194
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-29 (BiP2aa-vIGF2-PPT1; native human sequence)

<400>  194
atgaagctct ccctggtggc cgcgatgctg ctgctgctct gggtggcact gctgctgctc       60

agcgcggcga gggccgccgc gagtcgcacg ttgtgtggag gtgaactcgt cgacaccctt      120

cagttcgtat gtggagatcg cggtttcctc ttctcacgcc cagcttccag agtttcccga      180

agatcacgag gaatagttga ggagtgctgt tttcggtctt gtgatctggc tctcctcgag      240

acttattgtg ctacgccggc ccgctctgaa ggaggtggtg gcagtggagg aggagggagt      300

cggcctaggg cagtcccaac ccaggacccg ccggcgccgc tgccgttggt gatctggcat      360

gggatgggag acagctgttg caatccctta agcatgggtg ctattaaaaa aatggtggag      420

aagaaaatac ctggaattta cgtcttatct ttagagattg ggaagaccct gatggaggac      480

gtggagaaca gcttcttctt gaatgtcaat tcccaagtaa caacagtgtg tcaggcactt      540

gctaaggatc ctaaattgca gcaaggctac aatgctatgg gattctccca gggaggccaa      600

tttctgaggg cagtggctca gagatgccct tcacctccca tgatcaatct gatctcggtt      660

gggggacaac atcaaggtgt ttttggactc cctcgatgcc caggagagag ctctcacatc      720

tgtgacttca tccgaaaaac actgaatgct ggggcgtact ccaaagttgt tcaggaacgc      780

ctcgtgcaag ccgaatactg gcatgacccc ataaaggagg atgtgtatcg caaccacagc      840

atcttcttgg cagatataaa tcaggagcgg ggtatcaatg agtcctacaa gaaaaacctg      900

atggccctga agaagtttgt gatggtgaaa ttcctcaatg attccattgt ggaccctgta      960

gattcggagt ggtttggatt ttacagaagt ggccaagcca aggaaaccat tcccttacag     1020

gagacctccc tgtacacaca ggaccgcctg gggctaaagg aaatggacaa tgcaggacag     1080

ctagtgtttc tggctacaga aggggaccat cttcagttgt ctgaagaatg gttttatgcc     1140

cacatcatac cattccttgg atga                                            1164


<210>  195
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1 engineered

<400>  195
atggcgtcgc ccggctgcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggacccgccg gcgccgctgc cgttggtgat ctggcatggg      120

atgggagaca gctgttgcaa tcccttaagc atgggtgcta ttaaaaaaat ggtggagaag      180

aaaatacctg gaatttacgt cttatcttta gagattggga agaccctgat ggaggacgtg      240

gagaacagct tcttcttgaa tgtcaattcc caagtaacaa cagtgtgtca ggcacttgct      300

aaggatccta aattgcagca aggctacaat gctatgggat tctcccaggg aggccaattt      360

ctgagggcag tggctcagag atgcccttca cctcccatga tcaatctgat ctcggttggg      420

ggacaacatc aaggtgtttt tggactccct cgatgcccag gagagagctc tcacatctgt      480

gacttcatcc gaaaaacact gaatgctggg gcgtactcca aagttgttca ggaacgcctc      540

gtgcaagccg aatactggca tgaccccata aaggaggatg tgtatcgcaa ccacagcatc      600

ttcttggcag atataaatca ggagcggggt atcaatgagt cctacaagaa aaacctgatg      660

gccctgaaga agtttgtgat ggtgaaattc ctcaatgatt ccattgtgga ccctgtagat      720

tcggagtggt ttggatttta cagaagtggc caagccaagg aaaccattcc cttacaggag      780

acctccctgt acacacagga ccgcctgggg ctaaaggaaa tggacaatgc aggacagcta      840

gtgtttctgg ctacagaagg ggaccatctt cagttgtctg aagaatggtt ttatgcccac      900

atcataccat tccttggaag acctagagca gtgcctacgc agggagggag tgggagtgga      960

tccacttcat cctctagaac actgtgcgga ggggagcttg tagacactct tcagttcgtg     1020

tgtggagatc gcgggttcct cttctctcgc cccgcttcca gagtttcacg gaggtctagg     1080

ggtatagtag aggagtgttg tttcagggag tgtgacttgg cgctcctcga gacctattgc     1140

gcgacgccag ccaggtccga atga                                            1164


<210>  196
<211>  1692
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP1 wildtype

<400>  196
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt       60

tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt      120

gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga      180

ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg      240

accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa      300

aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg      360

acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac      420

tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca      480

caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca      540

tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta      600

accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc      660

agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg      720

gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg      780

gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg      840

atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga      900

caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg      960

catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc     1020

aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac     1080

agtggggccg ggtgttggtc tgtctctgga agacaccagt tccgccctac cttccctgcc     1140

tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca     1200

aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca     1260

taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt     1320

tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg     1380

gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg     1440

tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt     1500

ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt     1560

ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct     1620

ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta     1680

ctcaacccct ga                                                         1692


<210>  197
<211>  1935
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP1 engineered

<400>  197
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgctct       60

agaacactgt gcggagggga gcttgtagac actcttcagt tcgtgtgtgg agatcgcggg      120

ttcctcttct ctcgccccgc ttccagagtt tcacggaggt ctaggggtat agtagaggag      180

tgttgtttca ggtcctgtga cttggcgctc ctcgagacct attgcgcgac gccagccagg      240

tccgaaggag gtggtggcag tggaggagga gggagtagac ctagagcagt gcctacgcag      300

agttacagcc cggagcccga ccagcggagg acgctgcccc caggctgggt gtccctgggc      360

cgtgcggacc ctgaggaaga gctgagtctc acctttgccc tgagacagca gaatgtggaa      420

agactctcgg agctggtgca ggctgtgtcg gatcccagct ctcctcaata cggaaaatac      480

ctgaccctag agaatgtggc tgatctggtg aggccatccc cactgaccct ccacacggtg      540

caaaaatggc tcttggcagc cggagcccag aagtgccatt ctgtgatcac acaggacttt      600

ctgacttgct ggctgagcat ccgacaagca gagctgctgc tccctggggc tgagtttcat      660

cactatgtgg gaggacctac ggaaacccat gttgtaaggt ccccacatcc ctaccagctt      720

ccacaggcct tggcccccca tgtggacttt gtggggggac tgcaccgttt tcccccaaca      780

tcatccctga ggcaacgtcc tgagccgcag gtgacaggga ctgtaggcct gcatctgggg      840

gtaaccccct ctgtgatccg taagcgatac aacttgacct cacaagacgt gggctctggc      900

accagcaata acagccaagc ctgtgcccag ttcctggagc agtatttcca tgactcagac      960

ctggctcagt tcatgcgcct cttcggtggc aactttgcac atcaggcatc agtagcccgt     1020

gtggttggac aacagggccg gggccgggcc gggattgagg ccagtctaga tgtgcagtac     1080

ctgatgagtg ctggtgccaa catctccacc tgggtctaca gtagccctgg ccggcatgag     1140

ggacaggagc ccttcctgca gtggctcatg ctgctcagta atgagtcagc cctgccacat     1200

gtgcatactg tgagctatgg agatgatgag gactccctca gcagcgccta catccagcgg     1260

gtcaacactg agctcatgaa ggctgccgct cggggtctca ccctgctctt cgcctcaggt     1320

gacagtgggg ccgggtgttg gtctgtctct ggaagacacc agttccgccc taccttccct     1380

gcctccagcc cctatgtcac cacagtggga ggcacatcct tccaggaacc tttcctcatc     1440

acaaatgaaa ttgttgacta tatcagtggt ggtggcttca gcaatgtgtt cccacggcct     1500

tcataccagg aggaagctgt aacgaagttc ctgagctcta gcccccacct gccaccatcc     1560

agttacttca atgccagtgg ccgtgcctac ccagatgtgg ctgcactttc tgatggctac     1620

tgggtggtca gcaacagagt gcccattcca tgggtgtccg gaacctcggc ctctactcca     1680

gtgtttgggg ggatcctatc cttgatcaat gagcacagga tccttagtgg ccgcccccct     1740

cttggctttc tcaacccaag gctctaccag cagcatgggg caggactctt tgatgtaacc     1800

cgtggctgcc atgagtcctg tctggatgaa gaggtagagg gccagggttt ctgctctggt     1860

cctggctggg atcctgtaac aggctgggga acacccaact tcccagcttt gctgaagact     1920

ctactcaacc cctga                                                      1935


<210>  198
<211>  1041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AGA wildtype

<400>  198
atggcgcgga agtcgaactt gcctgtgctt ctcgtgccgt ttctgctctg ccaggcccta       60

gtgcgctgct ccagccctct gcccctggtc gtcaacactt ggccctttaa gaatgcaacc      120

gaagcagcgt ggagggcatt agcatctgga ggctctgccc tggatgcagt ggagagcggc      180

tgtgccatgt gtgagagaga gcagtgtgac ggctctgtag gctttggagg aagtcctgat      240

gaacttggag aaaccacact agatgccatg atcatggatg gcactactat ggatgtagga      300

gcagtaggag atctcagacg aattaaaaat gctattggtg tggcacggaa agtactggaa      360

catacaacac acacactttt agtaggagag tcagccacca catttgctca aagtatgggg      420

tttatcaatg aagacttatc taccactgct tctcaagctc ttcattcaga ttggcttgct      480

cggaattgcc agccaaatta ttggaggaat gttataccag atccctcaaa atactgcgga      540

ccctacaaac cacctggtat cttaaagcag gatattccta tccataaaga aacagaagat      600

gatcgtggtc atgacactat tggcatggtt gtaatccata agacaggaca tattgctgct      660

ggtacatcta caaatggtat aaaattcaaa atacatggcc gtgtaggaga ctcaccaata      720

cctggagctg gagcctatgc tgacgatact gcaggggcag ccgcagccac tgggaatggt      780

gatatattga tgcgcttcct gccaagctac caagctgtag aatacatgag aagaggagaa      840

gatccaacca tagcttgcca aaaagtgatt tcaagaatcc agaagcattt tccagaattc      900

tttggggctg ttatatgtgc caatgtgact ggaagttacg gtgctgcttg caataaactt      960

tcaacattta ctcagtttag tttcatggtt tataattccg aaaaaaatca gccaactgag     1020

gaaaaagtgg actgcatcta a                                               1041


<210>  199
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AGA engineered (N-terminal fusion)

<400>  199
atggcgcgga agtcgaactt gcctgtgctt ctcgtgccgt ttctgctctg ccaggcccta       60

gtgcgctgct ctagaacact gtgcggaggg gagcttgtag acactcttca gttcgtgtgt      120

ggagatcgcg ggttcctctt ctctcgcccc gcttccagag tttcacggag gtctaggggt      180

atagtagagg agtgttgttt caggtcctgt gacttggcgc tcctcgagac ctattgcgcg      240

acgccagcca ggtccgaagg aggtggtggc agtggaggag gagggagtag acctagagca      300

gtgcctacgc agtccagccc tctgcccctg gtcgtcaaca cttggccctt taagaatgca      360

accgaagcag cgtggagggc attagcatct ggaggctctg ccctggatgc agtggagagc      420

ggctgtgcca tgtgtgagag agagcagtgt gacggctctg taggctttgg aggaagtcct      480

gatgaacttg gagaaaccac actagatgcc atgatcatgg atggcactac tatggatgta      540

ggagcagtag gagatctcag acgaattaaa aatgctattg gtgtggcacg gaaagtactg      600

gaacatacaa cacacacact tttagtagga gagtcagcca ccacatttgc tcaaagtatg      660

gggtttatca atgaagactt atctaccact gcttctcaag ctcttcattc agattggctt      720

gctcggaatt gccagccaaa ttattggagg aatgttatac cagatccctc aaaatactgc      780

ggaccctaca aaccacctgg tatcttaaag caggatattc ctatccataa agaaacagaa      840

gatgatcgtg gtcatgacac tattggcatg gttgtaatcc ataagacagg acatattgct      900

gctggtacat ctacaaatgg tataaaattc aaaatacatg gccgtgtagg agactcacca      960

atacctggag ctggagccta tgctgacgat actgcagggg cagccgcagc cactgggaat     1020

ggtgatatat tgatgcgctt cctgccaagc taccaagctg tagaatacat gagaagagga     1080

gaagatccaa ccatagcttg ccaaaaagtg atttcaagaa tccagaagca ttttccagaa     1140

ttctttgggg ctgttatatg tgccaatgtg actggaagtt acggtgctgc ttgcaataaa     1200

ctttcaacat ttactcagtt tagtttcatg gtttataatt ccgaaaaaaa tcagccaact     1260

gaggaaaaag tggactgcat ctaa                                            1284


<210>  200
<211>  1251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GLA wildtype

<400>  200
atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg ggccctggac       60

aatggattgg caaggacgcc taccatgggc tggctgcact gggagcgctt catgtgcaac      120

cttgactgcc aggaagagcc agattcctgc atcagtgaga agctcttcat ggagatggca      180

gagctcatgg tctcagaagg ctggaaggat gcaggttatg agtacctctg cattgatgac      240

tgttggatgg ctccccaaag agattcagaa ggcagacttc aggcagaccc tcagcgcttt      300

cctcatggga ttcgccagct agctaattat gttcacagca aaggactgaa gctagggatt      360

tatgcagatg ttggaaataa aacctgcgca ggcttccctg ggagttttgg atactacgac      420

attgatgccc agacctttgc tgactgggga gtagatctgc taaaatttga tggttgttac      480

tgtgacagtt tggaaaattt ggcagatggt tataagcaca tgtccttggc cctgaatagg      540

actggcagaa gcattgtgta ctcctgtgag tggcctcttt atatgtggcc ctttcaaaag      600

cccaattata cagaaatccg acagtactgc aatcactggc gaaattttgc tgacattgat      660

gattcctgga aaagtataaa gagtatcttg gactggacat cttttaacca ggagagaatt      720

gttgatgttg ctggaccagg gggttggaat gacccagata tgttagtgat tggcaacttt      780

ggcctcagct ggaatcagca agtaactcag atggccctct gggctatcat ggctgctcct      840

ttattcatgt ctaatgacct ccgacacatc agccctcaag ccaaagctct ccttcaggat      900

aaggacgtaa ttgccatcaa tcaggacccc ttgggcaagc aagggtacca gcttagacag      960

ggagacaact ttgaagtgtg ggaacgacct ctctcaggct tagcctgggc tgtagctatg     1020

ataaaccggc aggagattgg tggacctcgc tcttatacca tcgcagttgc ttccctgggt     1080

aaaggagtgg cctgtaatcc tgcctgcttc atcacacagc tcctccctgt gaaaaggaag     1140

ctagggttct atgaatggac ttcaaggtta agaagtcaca taaatcccac aggcactgtt     1200

ttgcttcagc tagaaaatac aatgcagatg tcattaaaag acttacttta a              1251


<210>  201
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GLA engineered

<400>  201
atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg ggccctggac       60

aatggattgg caaggacgcc taccatgggc tggctgcact gggagcgctt catgtgcaac      120

cttgactgcc aggaagagcc agattcctgc atcagtgaga agctcttcat ggagatggca      180

gagctcatgg tctcagaagg ctggaaggat gcaggttatg agtacctctg cattgatgac      240

tgttggatgg ctccccaaag agattcagaa ggcagacttc aggcagaccc tcagcgcttt      300

cctcatggga ttcgccagct agctaattat gttcacagca aaggactgaa gctagggatt      360

tatgcagatg ttggaaataa aacctgcgca ggcttccctg ggagttttgg atactacgac      420

attgatgccc agacctttgc tgactgggga gtagatctgc taaaatttga tggttgttac      480

tgtgacagtt tggaaaattt ggcagatggt tataagcaca tgtccttggc cctgaatagg      540

actggcagaa gcattgtgta ctcctgtgag tggcctcttt atatgtggcc ctttcaaaag      600

cccaattata cagaaatccg acagtactgc aatcactggc gaaattttgc tgacattgat      660

gattcctgga aaagtataaa gagtatcttg gactggacat cttttaacca ggagagaatt      720

gttgatgttg ctggaccagg gggttggaat gacccagata tgttagtgat tggcaacttt      780

ggcctcagct ggaatcagca agtaactcag atggccctct gggctatcat ggctgctcct      840

ttattcatgt ctaatgacct ccgacacatc agccctcaag ccaaagctct ccttcaggat      900

aaggacgtaa ttgccatcaa tcaggacccc ttgggcaagc aagggtacca gcttagacag      960

ggagacaact ttgaagtgtg ggaacgacct ctctcaggct tagcctgggc tgtagctatg     1020

ataaaccggc aggagattgg tggacctcgc tcttatacca tcgcagttgc ttccctgggt     1080

aaaggagtgg cctgtaatcc tgcctgcttc atcacacagc tcctccctgt gaaaaggaag     1140

ctagggttct atgaatggac ttcaaggtta agaagtcaca taaatcccac aggcactgtt     1200

ttgcttcagc tagaaaatac aatgcagatg tcattaaaag acttacttta catccctgca     1260

aagcaggggc tgcagggagc ccagatgggg cagcccgggg gcggtggctc aggtggtgga     1320

ggttcaagaa cactgtgcgg aggggagctt gtagacactc ttcagttcgt gtgtggagat     1380

cgcgggttcc tcttctctcg ccccgcttcc agagtttcac ggaggtctag gggtatagta     1440

gaggagtgtt gtttcaggtc ctgtgacttg gcgctcctcg agacctattg cgcgacgcca     1500

gccaggtccg aataa                                                      1515


<210>  202
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiP-vIGF2-17-2GS-GAA

<400>  202
atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg ggcctctaga       60

acactgtgcg gaggggagct tgtagacact cttcagttcg tgtgtggaga tcgcgggttc      120

ctcttctctc gccccgcttc cagagtttca cggaggtcta ggggtatagt agaggagtgt      180

tgtttcaggg agtgtgactt ggcgctcctc gagacctatt gcgcgacgcc agccaggtcc      240

gaagggggcg gtggctcagg tggtggaggt agcagaccag ggccccggga tgcccaggca      300

caccccggcc gtcccagagc agtgcccaca cagtgcgacg tcccccccaa cagccgcttc      360

gattgcgccc ctgacaaggc catcacccag gaacagtgcg aggcccgcgg ctgttgctac      420

atccctgcaa agcaggggct gcagggagcc cagatggggc agccctggtg cttcttccca      480

cccagctacc ccagctacaa gctggagaac ctgagctcct ctgaaatggg ctacacggcc      540

accctgaccc gtaccacccc caccttcttc cccaaggaca tcctgaccct gcggctggac      600

gtgatgatgg agactgagaa ccgcctccac ttcacgatca aagatccagc taacaggcgc      660

tacgaggtgc ccttggagac cccgcatgtc cacagccggg caccgtcccc actctacagc      720

gtggagttct ccgaggagcc cttcggggtg atcgtgcgcc ggcagctgga cggccgcgtg      780

ctgctgaaca cgacggtggc gcccctgttc tttgcggacc agttccttca gctgtccacc      840

tcgctgccct cgcagtatat cacaggcctc gccgagcacc tcagtcccct gatgctcagc      900

accagctgga ccaggatcac cctgtggaac cgggaccttg cgcccacgcc cggtgcgaac      960

ctctacgggt ctcacccttt ctacctggcg ctggaggacg gcgggtcggc acacggggtg     1020

ttcctgctaa acagcaatgc catggatgtg gtcctgcagc cgagccctgc ccttagctgg     1080

aggtcgacag gtgggatcct ggatgtctac atcttcctgg gcccagagcc caagagcgtg     1140

gtgcagcagt acctggacgt tgtgggatac ccgttcatgc cgccatactg gggcctgggc     1200

ttccacctgt gccgctgggg ctactcctcc accgctatca cccgccaggt ggtggagaac     1260

atgaccaggg cccacttccc cctggacgtc cagtggaacg acctggacta catggactcc     1320

cggagggact tcacgttcaa caaggatggc ttccgggact tcccggccat ggtgcaggag     1380

ctgcaccagg gcggccggcg ctacatgatg atcgtggatc ctgccatcag cagctcgggc     1440

cctgccggga gctacaggcc ctacgacgag ggtctgcgga ggggggtttt catcaccaac     1500

gagaccggcc agccgctgat tgggaaggta tggcccgggt ccactgcctt ccccgacttc     1560

accaacccca cagccctggc ctggtgggag gacatggtgg ctgagttcca tgaccaggtg     1620

cccttcgacg gcatgtggat tgacatgaac gagccttcca acttcatcag gggctctgag     1680

gacggctgcc ccaacaatga gctggagaac ccaccctacg tgcctggggt ggttgggggg     1740

accctccagg cggccaccat ctgtgcctcc agccaccagt ttctctccac acactacaac     1800

ctgcacaacc tctacggcct gaccgaagcc atcgcctccc acagggcgct ggtgaaggct     1860

cgggggacac gcccatttgt gatctcccgc tcgacctttg ctggccacgg ccgatacgcc     1920

ggccactgga cgggggacgt gtggagctcc tgggagcagc tcgcctcctc cgtgccagaa     1980

atcctgcagt ttaacctgct gggggtgcct ctggtcgggg ccgacgtctg cggcttcctg     2040

ggcaacacct cagaggagct gtgtgtgcgc tggacccagc tgggggcctt ctaccccttc     2100

atgcggaacc acaacagcct gctcagtctg ccccaggagc cgtacagctt cagcgagccg     2160

gcccagcagg ccatgaggaa ggccctcacc ctgcgctacg cactcctccc ccacctctac     2220

acactgttcc accaggccca cgtcgcgggg gagaccgtgg cccggcccct cttcctggag     2280

ttccccaagg actctagcac ctggactgtg gaccaccagc tcctgtgggg ggaggccctg     2340

ctcatcaccc cagtgctcca ggccgggaag gccgaagtga ctggctactt ccccttgggc     2400

acatggtacg acctgcagac ggtgccagta gaggcccttg gcagcctccc acccccacct     2460

gcagctcccc gtgagccagc catccacagc gaggggcagt gggtgacgct gccggccccc     2520

ctggacacca tcaacgtcca cctccgggct gggtacatca tccccctgca gggccctggc     2580

ctcacaacca cagagtcccg ccagcagccc atggccctgg ctgtggccct gaccaagggt     2640

ggggaggccc gaggggagct gttctgggac gatggagaga gcctggaagt gctggagcga     2700

ggggcctaca cacaggtcat cttcctggcc aggaataaca cgatcgtgaa tgagctggta     2760

cgtgtgacca gtgagggagc tggcctgcag ctgcagaagg tgactgtcct gggcgtggcc     2820

acggcgcccc agcaggtcct ctccaacggt gtccctgtct ccaacttcac ctacagcccc     2880

gacaccaagg tcctggacat ctgtgtctcg ctgttgatgg gagagcagtt tctcgtcagc     2940

tggtgttag                                                             2949


<210>  203
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiP-vIGF2-20-2GS-GAA

<400>  203
atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg ggcctctaga       60

acactgtgcg gaggggagct tgtagacact cttcagttcg tgtgtggaga tcgcgggttc      120

ctcttctctc gccccgcttc cagagtttca cggaggtcta ggggtatact ggaggagtgt      180

tgtttcaggt cctgtgactt ggcgctcctc gagacctatt gcgcgacgcc agccaggtcc      240

gaagggggcg gtggctcagg tggtggaggt agcagaccag ggccccggga tgcccaggca      300

caccccggcc gtcccagagc agtgcccaca cagtgcgacg tcccccccaa cagccgcttc      360

gattgcgccc ctgacaaggc catcacccag gaacagtgcg aggcccgcgg ctgttgctac      420

atccctgcaa agcaggggct gcagggagcc cagatggggc agccctggtg cttcttccca      480

cccagctacc ccagctacaa gctggagaac ctgagctcct ctgaaatggg ctacacggcc      540

accctgaccc gtaccacccc caccttcttc cccaaggaca tcctgaccct gcggctggac      600

gtgatgatgg agactgagaa ccgcctccac ttcacgatca aagatccagc taacaggcgc      660

tacgaggtgc ccttggagac cccgcatgtc cacagccggg caccgtcccc actctacagc      720

gtggagttct ccgaggagcc cttcggggtg atcgtgcgcc ggcagctgga cggccgcgtg      780

ctgctgaaca cgacggtggc gcccctgttc tttgcggacc agttccttca gctgtccacc      840

tcgctgccct cgcagtatat cacaggcctc gccgagcacc tcagtcccct gatgctcagc      900

accagctgga ccaggatcac cctgtggaac cgggaccttg cgcccacgcc cggtgcgaac      960

ctctacgggt ctcacccttt ctacctggcg ctggaggacg gcgggtcggc acacggggtg     1020

ttcctgctaa acagcaatgc catggatgtg gtcctgcagc cgagccctgc ccttagctgg     1080

aggtcgacag gtgggatcct ggatgtctac atcttcctgg gcccagagcc caagagcgtg     1140

gtgcagcagt acctggacgt tgtgggatac ccgttcatgc cgccatactg gggcctgggc     1200

ttccacctgt gccgctgggg ctactcctcc accgctatca cccgccaggt ggtggagaac     1260

atgaccaggg cccacttccc cctggacgtc cagtggaacg acctggacta catggactcc     1320

cggagggact tcacgttcaa caaggatggc ttccgggact tcccggccat ggtgcaggag     1380

ctgcaccagg gcggccggcg ctacatgatg atcgtggatc ctgccatcag cagctcgggc     1440

cctgccggga gctacaggcc ctacgacgag ggtctgcgga ggggggtttt catcaccaac     1500

gagaccggcc agccgctgat tgggaaggta tggcccgggt ccactgcctt ccccgacttc     1560

accaacccca cagccctggc ctggtgggag gacatggtgg ctgagttcca tgaccaggtg     1620

cccttcgacg gcatgtggat tgacatgaac gagccttcca acttcatcag gggctctgag     1680

gacggctgcc ccaacaatga gctggagaac ccaccctacg tgcctggggt ggttgggggg     1740

accctccagg cggccaccat ctgtgcctcc agccaccagt ttctctccac acactacaac     1800

ctgcacaacc tctacggcct gaccgaagcc atcgcctccc acagggcgct ggtgaaggct     1860

cgggggacac gcccatttgt gatctcccgc tcgacctttg ctggccacgg ccgatacgcc     1920

ggccactgga cgggggacgt gtggagctcc tgggagcagc tcgcctcctc cgtgccagaa     1980

atcctgcagt ttaacctgct gggggtgcct ctggtcgggg ccgacgtctg cggcttcctg     2040

ggcaacacct cagaggagct gtgtgtgcgc tggacccagc tgggggcctt ctaccccttc     2100

atgcggaacc acaacagcct gctcagtctg ccccaggagc cgtacagctt cagcgagccg     2160

gcccagcagg ccatgaggaa ggccctcacc ctgcgctacg cactcctccc ccacctctac     2220

acactgttcc accaggccca cgtcgcgggg gagaccgtgg cccggcccct cttcctggag     2280

ttccccaagg actctagcac ctggactgtg gaccaccagc tcctgtgggg ggaggccctg     2340

ctcatcaccc cagtgctcca ggccgggaag gccgaagtga ctggctactt ccccttgggc     2400

acatggtacg acctgcagac ggtgccagta gaggcccttg gcagcctccc acccccacct     2460

gcagctcccc gtgagccagc catccacagc gaggggcagt gggtgacgct gccggccccc     2520

ctggacacca tcaacgtcca cctccgggct gggtacatca tccccctgca gggccctggc     2580

ctcacaacca cagagtcccg ccagcagccc atggccctgg ctgtggccct gaccaagggt     2640

ggggaggccc gaggggagct gttctgggac gatggagaga gcctggaagt gctggagcga     2700

ggggcctaca cacaggtcat cttcctggcc aggaataaca cgatcgtgaa tgagctggta     2760

cgtgtgacca gtgagggagc tggcctgcag ctgcagaagg tgactgtcct gggcgtggcc     2820

acggcgcccc agcaggtcct ctccaacggt gtccctgtct ccaacttcac ctacagcccc     2880

gacaccaagg tcctggacat ctgtgtctcg ctgttgatgg gagagcagtt tctcgtcagc     2940

tggtgttag                                                             2949


<210>  204
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiP-vIGF2-22-2GS-GAA

<400>  204
atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg ggcctctaga       60

acactgtgcg gaggggagct tgtagacact cttcagttcg tgtgtggaga tcgcgggttc      120

ctcttctctc gcggaggtgg aggttctagg ggtatagtag aggagtgttg tttcaggtcc      180

tgtgacttgg cgctcctcga gacctattgc gcgacgccag ccaggtccga agggggcggt      240

ggctcaggtg gtggaggtag cagaccaggg ccccgggatg cccaggcaca ccccggccgt      300

cccagagcag tgcccacaca gtgcgacgtc ccccccaaca gccgcttcga ttgcgcccct      360

gacaaggcca tcacccagga acagtgcgag gcccgcggct gttgctacat ccctgcaaag      420

caggggctgc agggagccca gatggggcag ccctggtgct tcttcccacc cagctacccc      480

agctacaagc tggagaacct gagctcctct gaaatgggct acacggccac cctgacccgt      540

accaccccca ccttcttccc caaggacatc ctgaccctgc ggctggacgt gatgatggag      600

actgagaacc gcctccactt cacgatcaaa gatccagcta acaggcgcta cgaggtgccc      660

ttggagaccc cgcatgtcca cagccgggca ccgtccccac tctacagcgt ggagttctcc      720

gaggagccct tcggggtgat cgtgcgccgg cagctggacg gccgcgtgct gctgaacacg      780

acggtggcgc ccctgttctt tgcggaccag ttccttcagc tgtccacctc gctgccctcg      840

cagtatatca caggcctcgc cgagcacctc agtcccctga tgctcagcac cagctggacc      900

aggatcaccc tgtggaaccg ggaccttgcg cccacgcccg gtgcgaacct ctacgggtct      960

caccctttct acctggcgct ggaggacggc gggtcggcac acggggtgtt cctgctaaac     1020

agcaatgcca tggatgtggt cctgcagccg agccctgccc ttagctggag gtcgacaggt     1080

gggatcctgg atgtctacat cttcctgggc ccagagccca agagcgtggt gcagcagtac     1140

ctggacgttg tgggataccc gttcatgccg ccatactggg gcctgggctt ccacctgtgc     1200

cgctggggct actcctccac cgctatcacc cgccaggtgg tggagaacat gaccagggcc     1260

cacttccccc tggacgtcca gtggaacgac ctggactaca tggactcccg gagggacttc     1320

acgttcaaca aggatggctt ccgggacttc ccggccatgg tgcaggagct gcaccagggc     1380

ggccggcgct acatgatgat cgtggatcct gccatcagca gctcgggccc tgccgggagc     1440

tacaggccct acgacgaggg tctgcggagg ggggttttca tcaccaacga gaccggccag     1500

ccgctgattg ggaaggtatg gcccgggtcc actgccttcc ccgacttcac caaccccaca     1560

gccctggcct ggtgggagga catggtggct gagttccatg accaggtgcc cttcgacggc     1620

atgtggattg acatgaacga gccttccaac ttcatcaggg gctctgagga cggctgcccc     1680

aacaatgagc tggagaaccc accctacgtg cctggggtgg ttggggggac cctccaggcg     1740

gccaccatct gtgcctccag ccaccagttt ctctccacac actacaacct gcacaacctc     1800

tacggcctga ccgaagccat cgcctcccac agggcgctgg tgaaggctcg ggggacacgc     1860

ccatttgtga tctcccgctc gacctttgct ggccacggcc gatacgccgg ccactggacg     1920

ggggacgtgt ggagctcctg ggagcagctc gcctcctccg tgccagaaat cctgcagttt     1980

aacctgctgg gggtgcctct ggtcggggcc gacgtctgcg gcttcctggg caacacctca     2040

gaggagctgt gtgtgcgctg gacccagctg ggggccttct accccttcat gcggaaccac     2100

aacagcctgc tcagtctgcc ccaggagccg tacagcttca gcgagccggc ccagcaggcc     2160

atgaggaagg ccctcaccct gcgctacgca ctcctccccc acctctacac actgttccac     2220

caggcccacg tcgcggggga gaccgtggcc cggcccctct tcctggagtt ccccaaggac     2280

tctagcacct ggactgtgga ccaccagctc ctgtgggggg aggccctgct catcacccca     2340

gtgctccagg ccgggaaggc cgaagtgact ggctacttcc ccttgggcac atggtacgac     2400

ctgcagacgg tgccagtaga ggcccttggc agcctcccac ccccacctgc agctccccgt     2460

gagccagcca tccacagcga ggggcagtgg gtgacgctgc cggcccccct ggacaccatc     2520

aacgtccacc tccgggctgg gtacatcatc cccctgcagg gccctggcct cacaaccaca     2580

gagtcccgcc agcagcccat ggccctggct gtggccctga ccaagggtgg ggaggcccga     2640

ggggagctgt tctgggacga tggagagagc ctggaagtgc tggagcgagg ggcctacaca     2700

caggtcatct tcctggccag gaataacacg atcgtgaatg agctggtacg tgtgaccagt     2760

gagggagctg gcctgcagct gcagaaggtg actgtcctgg gcgtggccac ggcgccccag     2820

caggtcctct ccaacggtgt ccctgtctcc aacttcacct acagccccga caccaaggtc     2880

ctggacatct gtgtctcgct gttgatggga gagcagtttc tcgtcagctg gtgttag        2937


<210>  205
<211>  894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-3 (BiP-PPT1; Codon optimized IDT)

<400>  205
atgaaactgt ctctggttgc agcaatgctc ttgctgttga gtgcggcccg cgcggatcca       60

cctgctcccc tgcccctcgt tatatggcat ggcatgggag attcctgttg taatcccctc      120

agcatggggg ccatcaaaaa aatggtggaa aaaaaaatac ctggcatata tgtactctca      180

cttgaaatcg gtaagaccct tatggaagac gtcgaaaatt ccttcttttt gaacgtgaac      240

tcacaagtta cgaccgtctg tcaagctctc gcgaaagacc ctaagctcca gcaaggttat      300

aatgcaatgg gcttctcaca gggaggtcag ttcttgcgag cggtagccca gaggtgtccg      360

tctccgccaa tgatcaactt gatctcagtg gggggtcagc accaaggcgt ttttggactc      420

cctagatgcc ctggagagag ctctcacatt tgcgatttta tacggaagac gctgaatgcc      480

ggcgcgtatt caaaggtcgt tcaagagcga ctcgtccagg ctgaatactg gcacgatccg      540

attaaggaag acgtgtatcg aaaccattct atctttcttg ccgacattaa ccaggagcga      600

gggatcaacg aaagttataa aaaaaacctg atggcactca agaaatttgt aatggttaaa      660

ttcctgaacg attcaatagt tgatccggtg gattccgagt ggttcggctt ctaccggtcc      720

ggtcaggcca aggaaacaat cccattgcaa gaaaccagtc tctatactca ggaccgcctg      780

ggtctgaaag aaatggacaa cgctggccaa cttgtttttc tggcaacgga gggtgatcac      840

ttgcagctct ctgaagaatg gttttacgca cacatcattc ctttccttgg ttaa            894


<210>  206
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-4 (BiP-vIGF2-PPT1; Codon optimized IDT)

<400>  206
atgaagttgt ccctcgtagc tgcaatgttg ctgctcctca gtgcagcgcg ggcaagtcgc       60

acgttgtgtg gaggtgaact cgtcgacacc cttcagttcg tatgtggaga tcgcggtttc      120

ctcttctcac gcccagcttc cagagtttcc cgaagatcac gaggaatagt tgaggagtgc      180

tgttttcggt cttgtgatct ggctctcctc gagacttatt gtgctacgcc ggcccgctct      240

gaaggaggtg gtggcagtgg aggaggaggg agtcggccta gggcagtccc aacccaggat      300

cccccagcac ccctccccct ggtaatttgg catggaatgg gtgattcctg ctgtaaccca      360

ctctcaatgg gggcaattaa gaaaatggta gagaaaaaga tccctggcat ttatgttctg      420

tcactcgaaa tcggtaaaac gctcatggag gacgtagaaa acagcttttt tctgaatgtt      480

aattcacagg ttaccacggt ctgccaagca ttggcaaagg acccgaaatt gcaacaaggc      540

tataacgcga tggggttcag ccaaggcggg cagtttcttc gagctgtggc tcagcgctgc      600

ccttccccac cgatgataaa tttgattagc gtagggggac aacatcaagg ggttttcggt      660

ttgccaaggt gtcctggcga atcttcacat atttgcgact ttatacggaa gaccttgaat      720

gcgggggcgt atagtaaagt cgtccaggaa cggcttgtcc aagctgaata ctggcacgat      780

cccatcaaag aagatgtcta tcggaatcac agcatttttc tcgccgacat aaaccaagaa      840

cgcggaatta atgagtcata caagaagaac ttgatggcac ttaaaaaatt tgtgatggtt      900

aagtttttga atgatagtat cgtagatccc gtagatagtg aatggtttgg tttctatcga      960

tccggacagg ctaaagaaac gataccattg caggaaacct ctttgtatac tcaagatagg     1020

ttgggcctca aggagatgga taatgcgggg caacttgtct tcctcgcgac tgagggtgac     1080

cacctccagc tcagcgagga atggttttac gcccacatca ttcctttcct tggttaa        1137


<210>  207
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-5 (wt-PPT1-vIGF2; Codon optimized IDT)

<400>  207
atggcaagtc cagggtgtct ttggttgctc gcggttgcct tgctcccttg gacgtgcgcg       60

tcccgagccc ttcaacacct cgatccacca gccccgcttc ctctcgtgat atggcacggc      120

atgggcgaca gttgctgcaa tcccttgtct atgggcgcaa ttaaaaagat ggtggaaaag      180

aaaatccctg gtatctacgt tttgagcctc gaaattggga aaacgctcat ggaggatgtc      240

gagaacagct tctttcttaa cgtcaattcc caagttacca cggtttgtca agccttggcg      300

aaagatccca agcttcagca agggtataac gctatgggat ttagccaggg cggacagttc      360

ctgagggcgg tagcacagag gtgtcctagt ccaccaatga taaatctcat ctcagtcggg      420

ggccagcacc agggcgtctt cgggcttcct cgatgccccg gcgaatccag ccacatatgt      480

gacttcatta gaaaaacttt gaatgcaggg gcctacagta aagtggttca agaacgcctg      540

gtacaagcag agtattggca tgacccgatt aaggaagatg tctacagaaa tcactctatt      600

tttttggcgg acatcaatca ggaacgaggc attaacgagt cttacaagaa gaacctgatg      660

gcgctgaaaa agttcgtcat ggtcaagttc ttgaatgact ccattgtcga tcctgtagac      720

agcgagtggt ttggcttcta caggtctggt caagcaaagg agacaatacc acttcaggaa      780

accagtctct atacacaaga cagactgggt ttgaaggaaa tggacaatgc aggccaactg      840

gtattcctgg ctacagaggg agatcatctt caactgagcg aagagtggtt ttatgcccac      900

ataatcccct ttctgggaag acctagagca gtgcctacgc agggtggtgg tggctctgga      960

ggaggaggct ccaggactct gtgtgggggc gagctggtgg acaccttgca attcgtgtgt     1020

ggcgaccgag gatttctgtt cagtcgacct gcctcaagag taagccggag gagtcggggg     1080

atcgttgaag aatgctgttt ccggagctgc gacttggcgt tgctcgagac ttattgtgcc     1140

acacctgcaa ggagtgagtg a                                               1161


<210>  208
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-9 (wt-PPT1; native human sequence)

<400>  208
atggcgtcgc ccggctgcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggacccgccg gcgccgctgc cgttggtgat ctggcatggg      120

atgggagaca gctgttgcaa tcccttaagc atgggtgcta ttaaaaaaat ggtggagaag      180

aaaatacctg gaatttacgt cttatcttta gagattggga agaccctgat ggaggacgtg      240

gagaacagct tcttcttgaa tgtcaattcc caagtaacaa cagtgtgtca ggcacttgct      300

aaggatccta aattgcagca aggctacaat gctatgggat tctcccaggg aggccaattt      360

ctgagggcag tggctcagag atgcccttca cctcccatga tcaatctgat ctcggttggg      420

ggacaacatc aaggtgtttt tggactccct cgatgcccag gagagagctc tcacatctgt      480

gacttcatcc gaaaaacact gaatgctggg gcgtactcca aagttgttca ggaacgcctc      540

gtgcaagccg aatactggca tgaccccata aaggaggatg tgtatcgcaa ccacagcatc      600

ttcttggcag atataaatca ggagcggggt atcaatgagt cctacaagaa aaacctgatg      660

gccctgaaga agtttgtgat ggtgaaattc ctcaatgatt ccattgtgga ccctgtagat      720

tcggagtggt ttggatttta cagaagtggc caagccaagg aaaccattcc cttacaggag      780

acctccctgt acacacagga ccgcctgggg ctaaaggaaa tggacaatgc aggacagcta      840

gtgtttctgg ctacagaagg ggaccatctt cagttgtctg aagaatggtt ttatgcccac      900

atcataccat tccttggatg a                                                921


<210>  209
<211>  1161
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-10 (wt-PPT1-vIGF2_2; Codon optimized IDT)

<400>  209
atggcatcac cgggttgcct ctggttgttg gccgttgcgt tgcttccgtg gacatgtgca       60

tcaagagctc ttcaacatct ggatccccca gctcccctgc cgctcgtaat ctggcacggg      120

atgggggatt catgttgtaa cccgttgtca atgggcgcga taaaaaagat ggttgaaaag      180

aagattccag gcatctacgt tctgtccctg gaaatcggta agacactgat ggaagacgtg      240

gagaactcct tctttctcaa cgtcaatagt caggtcacta ccgtctgtca agcattggca      300

aaggacccta aacttcagca ggggtacaat gcgatggggt ttagccaggg cggacagttt      360

cttagagccg tcgcacagcg ctgtccatct cccccgatga ttaaccttat atctgtcggg      420

ggacaacacc agggtgtttt tggtcttcct cgctgtcctg gtgaaagctc ccacatctgt      480

gatttcatac gcaaaacgtt gaacgcagga gcttatagta aagtcgtcca agaacggctt      540

gttcaagcgg agtattggca tgacccaata aaagaagacg tttataggaa tcactctatc      600

ttcttggccg atatcaacca agaacgcgga atcaacgaaa gctacaaaaa gaatcttatg      660

gctctcaaga aatttgttat ggtgaaattc cttaatgact ctatagtaga tcctgtcgat      720

tcagaatggt tcgggttcta caggtctggc caggcgaagg agactattcc cctccaagaa      780

acgtctctct atacacaaga cagactcgga ctgaaagaga tggataatgc gggccagttg      840

gtcttcttgg ctacggaagg cgatcatctc caactctccg aagagtggtt ctatgcccat      900

ataatcccgt tcctgggcag acctagagca gtgcctacgc agggagggag tgggagtgga      960

tccacttcat ccaggactct gtgtgggggc gagctggtgg acaccttgca attcgtgtgt     1020

ggcgaccgag gatttctgtt cagtcgacct gcctcaagag taagccggag gagtcggggg     1080

atcgttgaag aatgctgttt ccggagctgc gacttggcgt tgctcgagac ttattgtgcc     1140

acacctgcaa ggagtgaatg a                                               1161


<210>  210
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-11 (BiP-PPT1_2; Codon optimized IDT)

<400>  210
atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg ggcctcaaga       60

gctcttcaac atctggatcc cccagctccc ctgccgctcg taatctggca cgggatgggg      120

gattcatgtt gtaacccgtt gtcaatgggc gcgataaaaa agatggttga aaagaagatt      180

ccaggcatct acgttctgtc cctggaaatc ggtaagacac tgatggaaga cgtggagaac      240

tccttctttc tcaacgtcaa tagtcaggtc actaccgtct gtcaagcatt ggcaaaggac      300

cctaaacttc agcaggggta caatgcgatg gggtttagcc agggcggaca gtttcttaga      360

gccgtcgcac agcgctgtcc atctcccccg atgattaacc ttatatctgt cgggggacaa      420

caccagggtg tttttggtct tcctcgctgt cctggtgaaa gctcccacat ctgtgatttc      480

atacgcaaaa cgttgaacgc aggagcttat agtaaagtcg tccaagaacg gcttgttcaa      540

gcggagtatt ggcatgaccc aataaaagaa gacgtttata ggaatcactc tatcttcttg      600

gccgatatca accaagaacg cggaatcaac gaaagctaca aaaagaatct tatggctctc      660

aagaaatttg ttatggtgaa attccttaat gactctatag tagatcctgt cgattcagaa      720

tggttcgggt tctacaggtc tggccaggcg aaggagacta ttcccctcca agaaacgtct      780

ctctatacac aagacagact cggactgaaa gagatggata atgcgggcca gttggtcttc      840

ttggctacgg aaggcgatca tctccaactc tccgaagagt ggttctatgc ccatataatc      900

ccgttcctgg gctaa                                                       915


<210>  211
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-12 (BiPaa-PPT1_2; Codon optimized IDT)

<400>  211
atgaagctct ccctggtggc cgcgatgctg ctgctgctca gcgcggcgcg ggcctcaaga       60

gctcttcaac atctggatcc cccagctccc ctgccgctcg taatctggca cgggatgggg      120

gattcatgtt gtaacccgtt gtcaatgggc gcgataaaaa agatggttga aaagaagatt      180

ccaggcatct acgttctgtc cctggaaatc ggtaagacac tgatggaaga cgtggagaac      240

tccttctttc tcaacgtcaa tagtcaggtc actaccgtct gtcaagcatt ggcaaaggac      300

cctaaacttc agcaggggta caatgcgatg gggtttagcc agggcggaca gtttcttaga      360

gccgtcgcac agcgctgtcc atctcccccg atgattaacc ttatatctgt cgggggacaa      420

caccagggtg tttttggtct tcctcgctgt cctggtgaaa gctcccacat ctgtgatttc      480

atacgcaaaa cgttgaacgc aggagcttat agtaaagtcg tccaagaacg gcttgttcaa      540

gcggagtatt ggcatgaccc aataaaagaa gacgtttata ggaatcactc tatcttcttg      600

gccgatatca accaagaacg cggaatcaac gaaagctaca aaaagaatct tatggctctc      660

aagaaatttg ttatggtgaa attccttaat gactctatag tagatcctgt cgattcagaa      720

tggttcgggt tctacaggtc tggccaggcg aaggagacta ttcccctcca agaaacgtct      780

ctctatacac aagacagact cggactgaaa gagatggata atgcgggcca gttggtcttc      840

ttggctacgg aaggcgatca tctccaactc tccgaagagt ggttctatgc ccatataatc      900

ccgttcctgg gctaa                                                       915


<210>  212
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-13 (BiPaa-PPT1; Codon optimized IDT)

<400>  212
atgaaactgt ctctggttgc agcaatgctc ttgctgttga gtgcggcccg cgcggcggcc       60

gatccacctg ctcccctgcc cctcgttata tggcatggca tgggagattc ctgttgtaat      120

cccctcagca tgggggccat caaaaaaatg gtggaaaaaa aaatacctgg catatatgta      180

ctctcacttg aaatcggtaa gacccttatg gaagacgtcg aaaattcctt ctttttgaac      240

gtgaactcac aagttacgac cgtctgtcaa gctctcgcga aagaccctaa gctccagcaa      300

ggttataatg caatgggctt ctcacaggga ggtcagttct tgcgagcggt agcccagagg      360

tgtccgtctc cgccaatgat caacttgatc tcagtggggg gtcagcacca aggcgttttt      420

ggactcccta gatgccctgg agagagctct cacatttgcg attttatacg gaagacgctg      480

aatgccggcg cgtattcaaa ggtcgttcaa gagcgactcg tccaggctga atactggcac      540

gatccgatta aggaagacgt gtatcgaaac cattctatct ttcttgccga cattaaccag      600

gagcgaggga tcaacgaaag ttataaaaaa aacctgatgg cactcaagaa atttgtaatg      660

gttaaattcc tgaacgattc aatagttgat ccggtggatt ccgagtggtt cggcttctac      720

cggtccggtc aggccaagga aacaatccca ttgcaagaaa ccagtctcta tactcaggac      780

cgcctgggtc tgaaagaaat ggacaacgct ggccaacttg tttttctggc aacggagggt      840

gatcacttgc agctctctga agaatggttt tacgcacaca tcattccttt ccttggttaa      900


<210>  213
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-14 (BiP1-vIGF2-PPT1; Codon optimized IDT)

<400>  213
atgaagctca gtctcgtggc agctatgctc ctcctgctgt ccctggttgc ggcaatgttg       60

ctcttgctga gcgccgcgag agcaagtcgc acgttgtgtg gaggtgaact cgtcgacacc      120

cttcagttcg tatgtggaga tcgcggtttc ctcttctcac gcccagcttc cagagtttcc      180

cgaagatcac gaggaatagt tgaggagtgc tgttttcggt cttgtgatct ggctctcctc      240

gagacttatt gtgctacgcc ggcccgctct gaaggaggtg gtggcagtgg aggaggaggg      300

agtcggccta gggcagtccc aacccaggat cccccagcac ccctccccct ggtaatttgg      360

catggaatgg gtgattcctg ctgtaaccca ctctcaatgg gggcaattaa gaaaatggta      420

gagaaaaaga tccctggcat ttatgttctg tcactcgaaa tcggtaaaac gctcatggag      480

gacgtagaaa acagcttttt tctgaatgtt aattcacagg ttaccacggt ctgccaagca      540

ttggcaaagg acccgaaatt gcaacaaggc tataacgcga tggggttcag ccaaggcggg      600

cagtttcttc gagctgtggc tcagcgctgc ccttccccac cgatgataaa tttgattagc      660

gtagggggac aacatcaagg ggttttcggt ttgccaaggt gtcctggcga atcttcacat      720

atttgcgact ttatacggaa gaccttgaat gcgggggcgt atagtaaagt cgtccaggaa      780

cggcttgtcc aagctgaata ctggcacgat cccatcaaag aagatgtcta tcggaatcac      840

agcatttttc tcgccgacat aaaccaagaa cgcggaatta atgagtcata caagaagaac      900

ttgatggcac ttaaaaaatt tgtgatggtt aagtttttga atgatagtat cgtagatccc      960

gtagatagtg aatggtttgg tttctatcga tccggacagg ctaaagaaac gataccattg     1020

caggaaacct ctttgtatac tcaagatagg ttgggcctca aggagatgga taatgcgggg     1080

caacttgtct tcctcgcgac tgagggtgac cacctccagc tcagcgagga atggttttac     1140

gcccacatca ttcctttcct tggttaa                                         1167


<210>  214
<211>  1173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-15 (BiP1aa-vIGF2-PPT1; Codon optimized IDT)

<400>  214
atgaagctca gtctcgtggc agctatgctc ctcctgctgt ccctggttgc ggcaatgttg       60

ctcttgctga gcgccgcgag agcagcagct agtcgcacgt tgtgtggagg tgaactcgtc      120

gacacccttc agttcgtatg tggagatcgc ggtttcctct tctcacgccc agcttccaga      180

gtttcccgaa gatcacgagg aatagttgag gagtgctgtt ttcggtcttg tgatctggct      240

ctcctcgaga cttattgtgc tacgccggcc cgctctgaag gaggtggtgg cagtggagga      300

ggagggagtc ggcctagggc agtcccaacc caggatcccc cagcacccct ccccctggta      360

atttggcatg gaatgggtga ttcctgctgt aacccactct caatgggggc aattaagaaa      420

atggtagaga aaaagatccc tggcatttat gttctgtcac tcgaaatcgg taaaacgctc      480

atggaggacg tagaaaacag cttttttctg aatgttaatt cacaggttac cacggtctgc      540

caagcattgg caaaggaccc gaaattgcaa caaggctata acgcgatggg gttcagccaa      600

ggcgggcagt ttcttcgagc tgtggctcag cgctgccctt ccccaccgat gataaatttg      660

attagcgtag ggggacaaca tcaaggggtt ttcggtttgc caaggtgtcc tggcgaatct      720

tcacatattt gcgactttat acggaagacc ttgaatgcgg gggcgtatag taaagtcgtc      780

caggaacggc ttgtccaagc tgaatactgg cacgatccca tcaaagaaga tgtctatcgg      840

aatcacagca tttttctcgc cgacataaac caagaacgcg gaattaatga gtcatacaag      900

aagaacttga tggcacttaa aaaatttgtg atggttaagt ttttgaatga tagtatcgta      960

gatcccgtag atagtgaatg gtttggtttc tatcgatccg gacaggctaa agaaacgata     1020

ccattgcagg aaacctcttt gtatactcaa gataggttgg gcctcaagga gatggataat     1080

gcggggcaac ttgtcttcct cgcgactgag ggtgaccacc tccagctcag cgaggaatgg     1140

ttttacgccc acatcattcc tttccttggt taa                                  1173


<210>  215
<211>  951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-16 (BiP1aa-PPT1_2; Codon optimized IDT)

<400>  215
atgaagctca gtctcgtggc agctatgctc ctcctgctgt ccctggttgc ggcaatgttg       60

ctcttgctga gcgccgcgag agcagccgcg tcaagagctc ttcaacatct ggatccccca      120

gctcccctgc cgctcgtaat ctggcacggg atgggggatt catgttgtaa cccgttgtca      180

atgggcgcga taaaaaagat ggttgaaaag aagattccag gcatctacgt tctgtccctg      240

gaaatcggta agacactgat ggaagacgtg gagaactcct tctttctcaa cgtcaatagt      300

caggtcacta ccgtctgtca agcattggca aaggacccta aacttcagca ggggtacaat      360

gcgatggggt ttagccaggg cggacagttt cttagagccg tcgcacagcg ctgtccatct      420

cccccgatga ttaaccttat atctgtcggg ggacaacacc agggtgtttt tggtcttcct      480

cgctgtcctg gtgaaagctc ccacatctgt gatttcatac gcaaaacgtt gaacgcagga      540

gcttatagta aagtcgtcca agaacggctt gttcaagcgg agtattggca tgacccaata      600

aaagaagacg tttataggaa tcactctatc ttcttggccg atatcaacca agaacgcgga      660

atcaacgaaa gctacaaaaa gaatcttatg gctctcaaga aatttgttat ggtgaaattc      720

cttaatgact ctatagtaga tcctgtcgat tcagaatggt tcgggttcta caggtctggc      780

caggcgaagg agactattcc cctccaagaa acgtctctct atacacaaga cagactcgga      840

ctgaaagaga tggataatgc gggccagttg gtcttcttgg ctacggaagg cgatcatctc      900

caactctccg aagagtggtt ctatgcccat ataatcccgt tcctgggcta a               951


<210>  216
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-17 (wt-PPT1-C6S; natural human sequence)

<400>  216
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggacccgccg gcgccgctgc cgttggtgat ctggcatggg      120

atgggagaca gctgttgcaa tcccttaagc atgggtgcta ttaaaaaaat ggtggagaag      180

aaaatacctg gaatttacgt cttatcttta gagattggga agaccctgat ggaggacgtg      240

gagaacagct tcttcttgaa tgtcaattcc caagtaacaa cagtgtgtca ggcacttgct      300

aaggatccta aattgcagca aggctacaat gctatgggat tctcccaggg aggccaattt      360

ctgagggcag tggctcagag atgcccttca cctcccatga tcaatctgat ctcggttggg      420

ggacaacatc aaggtgtttt tggactccct cgatgcccag gagagagctc tcacatctgt      480

gacttcatcc gaaaaacact gaatgctggg gcgtactcca aagttgttca ggaacgcctc      540

gtgcaagccg aatactggca tgaccccata aaggaggatg tgtatcgcaa ccacagcatc      600

ttcttggcag atataaatca ggagcggggt atcaatgagt cctacaagaa aaacctgatg      660

gccctgaaga agtttgtgat ggtgaaattc ctcaatgatt ccattgtgga ccctgtagat      720

tcggagtggt ttggatttta cagaagtggc caagccaagg aaaccattcc cttacaggag      780

acctccctgt acacacagga ccgcctgggg ctaaaggaaa tggacaatgc aggacagcta      840

gtgtttctgg ctacagaagg ggaccatctt cagttgtctg aagaatggtt ttatgcccac      900

atcataccat tccttggatg a                                                921


<210>  217
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-18 (BiP2aa-PPT1; Codon optimized IDT)

<400>  217
atgaagctct ccctggtggc cgcgatgctg ctgctgctct gggtggcact gctgctgctc       60

agcgcggcga gggccgccgc gtcaagagct cttcaacatc tggatccccc agctcccctg      120

ccgctcgtaa tctggcacgg gatgggggat tcatgttgta acccgttgtc aatgggcgcg      180

ataaaaaaga tggttgaaaa gaagattcca ggcatctacg ttctgtccct ggaaatcggt      240

aagacactga tggaagacgt ggagaactcc ttctttctca acgtcaatag tcaggtcact      300

accgtctgtc aagcattggc aaaggaccct aaacttcagc aggggtacaa tgcgatgggg      360

tttagccagg gcggacagtt tcttagagcc gtcgcacagc gctgtccatc tcccccgatg      420

attaacctta tatctgtcgg gggacaacac cagggtgttt ttggtcttcc tcgctgtcct      480

ggtgaaagct cccacatctg tgatttcata cgcaaaacgt tgaacgcagg agcttatagt      540

aaagtcgtcc aagaacggct tgttcaagcg gagtattggc atgacccaat aaaagaagac      600

gtttatagga atcactctat cttcttggcc gatatcaacc aagaacgcgg aatcaacgaa      660

agctacaaaa agaatcttat ggctctcaag aaatttgtta tggtgaaatt ccttaatgac      720

tctatagtag atcctgtcga ttcagaatgg ttcgggttct acaggtctgg ccaggcgaag      780

gagactattc ccctccaaga aacgtctctc tatacacaag acagactcgg actgaaagag      840

atggataatg cgggccagtt ggtcttcttg gctacggaag gcgatcatct ccaactctcc      900

gaagagtggt tctatgccca tataatcccg ttcctgggct aa                         942


<210>  218
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-19 (GaussiaAA-PPT1_2; Codon optimized IDT)

<400>  218
atgggtgtaa aggtgttgtt cgctcttatc tgcattgccg ttgcagaagc tgccgcgtca       60

agagctcttc aacatctgga tcccccagct cccctgccgc tcgtaatctg gcacgggatg      120

ggggattcat gttgtaaccc gttgtcaatg ggcgcgataa aaaagatggt tgaaaagaag      180

attccaggca tctacgttct gtccctggaa atcggtaaga cactgatgga agacgtggag      240

aactccttct ttctcaacgt caatagtcag gtcactaccg tctgtcaagc attggcaaag      300

gaccctaaac ttcagcaggg gtacaatgcg atggggttta gccagggcgg acagtttctt      360

agagccgtcg cacagcgctg tccatctccc ccgatgatta accttatatc tgtcggggga      420

caacaccagg gtgtttttgg tcttcctcgc tgtcctggtg aaagctccca catctgtgat      480

ttcatacgca aaacgttgaa cgcaggagct tatagtaaag tcgtccaaga acggcttgtt      540

caagcggagt attggcatga cccaataaaa gaagacgttt ataggaatca ctctatcttc      600

ttggccgata tcaaccaaga acgcggaatc aacgaaagct acaaaaagaa tcttatggct      660

ctcaagaaat ttgttatggt gaaattcctt aatgactcta tagtagatcc tgtcgattca      720

gaatggttcg ggttctacag gtctggccag gcgaaggaga ctattcccct ccaagaaacg      780

tctctctata cacaagacag actcggactg aaagagatgg ataatgcggg ccagttggtc      840

ttcttggcta cggaaggcga tcatctccaa ctctccgaag agtggttcta tgcccatata      900

atcccgttcc tgggctaa                                                    918


<210>  219
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-20 (GaussiaAA-vIGF2-PPT1; Codon optimized IDT)

<400>  219
atgggtgtaa aggtgttgtt cgctcttatc tgcattgccg ttgcagaagc tgcagctagt       60

cgcacgttgt gtggaggtga actcgtcgac acccttcagt tcgtatgtgg agatcgcggt      120

ttcctcttct cacgcccagc ttccagagtt tcccgaagat cacgaggaat agttgaggag      180

tgctgttttc ggtcttgtga tctggctctc ctcgagactt attgtgctac gccggcccgc      240

tctgaaggag gtggtggcag tggaggagga gggagtcggc ctagggcagt cccaacccag      300

gatcccccag cacccctccc cctggtaatt tggcatggaa tgggtgattc ctgctgtaac      360

ccactctcaa tgggggcaat taagaaaatg gtagagaaaa agatccctgg catttatgtt      420

ctgtcactcg aaatcggtaa aacgctcatg gaggacgtag aaaacagctt ttttctgaat      480

gttaattcac aggttaccac ggtctgccaa gcattggcaa aggacccgaa attgcaacaa      540

ggctataacg cgatggggtt cagccaaggc gggcagtttc ttcgagctgt ggctcagcgc      600

tgcccttccc caccgatgat aaatttgatt agcgtagggg gacaacatca aggggttttc      660

ggtttgccaa ggtgtcctgg cgaatcttca catatttgcg actttatacg gaagaccttg      720

aatgcggggg cgtatagtaa agtcgtccag gaacggcttg tccaagctga atactggcac      780

gatcccatca aagaagatgt ctatcggaat cacagcattt ttctcgccga cataaaccaa      840

gaacgcggaa ttaatgagtc atacaagaag aacttgatgg cacttaaaaa atttgtgatg      900

gttaagtttt tgaatgatag tatcgtagat cccgtagata gtgaatggtt tggtttctat      960

cgatccggac aggctaaaga aacgatacca ttgcaggaaa cctctttgta tactcaagat     1020

aggttgggcc tcaaggagat ggataatgcg gggcaacttg tcttcctcgc gactgagggt     1080

gaccacctcc agctcagcga ggaatggttt tacgcccaca tcattccttt ccttggttaa     1140


<210>  220
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-21 (ppt2ss-PPT1; Codon optimized IDT)

<400>  220
atgctggggc tctgggggca gcggctcccc gcggcgtggg tcctgcttct gttgcctttc       60

ctgccgctgc tgctgcttgc agatccccca gctcccctgc cgctcgtaat ctggcacggg      120

atgggggatt catgttgtaa cccgttgtca atgggcgcga taaaaaagat ggttgaaaag      180

aagattccag gcatctacgt tctgtccctg gaaatcggta agacactgat ggaagacgtg      240

gagaactcct tctttctcaa cgtcaatagt caggtcacta ccgtctgtca agcattggca      300

aaggacccta aacttcagca ggggtacaat gcgatggggt ttagccaggg cggacagttt      360

cttagagccg tcgcacagcg ctgtccatct cccccgatga ttaaccttat atctgtcggg      420

ggacaacacc agggtgtttt tggtcttcct cgctgtcctg gtgaaagctc ccacatctgt      480

gatttcatac gcaaaacgtt gaacgcagga gcttatagta aagtcgtcca agaacggctt      540

gttcaagcgg agtattggca tgacccaata aaagaagacg tttataggaa tcactctatc      600

ttcttggccg atatcaacca agaacgcgga atcaacgaaa gctacaaaaa gaatcttatg      660

gctctcaaga aatttgttat ggtgaaattc cttaatgact ctatagtaga tcctgtcgat      720

tcagaatggt tcgggttcta caggtctggc caggcgaagg agactattcc cctccaagaa      780

acgtctctct atacacaaga cagactcgga ctgaaagaga tggataatgc gggccagttg      840

gtcttcttgg ctacggaagg cgatcatctc caactctccg aagagtggtt ctatgcccat      900

ataatcccgt tcctgggcta a                                                921


<210>  221
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-22 (ppt2ss-PPT1_2; Codon optimized IDT)

<400>  221
atgctggggc tctgggggca gcggctcccc gcggcgtggg tcctgcttct gttgcctttc       60

ctgccgctgc tgctgcttgc atcaagagct cttcaacatc tggatccccc agctcccctg      120

ccgctcgtaa tctggcacgg gatgggggat tcatgttgta acccgttgtc aatgggcgcg      180

ataaaaaaga tggttgaaaa gaagattcca ggcatctacg ttctgtccct ggaaatcggt      240

aagacactga tggaagacgt ggagaactcc ttctttctca acgtcaatag tcaggtcact      300

accgtctgtc aagcattggc aaaggaccct aaacttcagc aggggtacaa tgcgatgggg      360

tttagccagg gcggacagtt tcttagagcc gtcgcacagc gctgtccatc tcccccgatg      420

attaacctta tatctgtcgg gggacaacac cagggtgttt ttggtcttcc tcgctgtcct      480

ggtgaaagct cccacatctg tgatttcata cgcaaaacgt tgaacgcagg agcttatagt      540

aaagtcgtcc aagaacggct tgttcaagcg gagtattggc atgacccaat aaaagaagac      600

gtttatagga atcactctat cttcttggcc gatatcaacc aagaacgcgg aatcaacgaa      660

agctacaaaa agaatcttat ggctctcaag aaatttgtta tggtgaaatt ccttaatgac      720

tctatagtag atcctgtcga ttcagaatgg ttcgggttct acaggtctgg ccaggcgaag      780

gagactattc ccctccaaga aacgtctctc tatacacaag acagactcgg actgaaagag      840

atggataatg cgggccagtt ggtcttcttg gctacggaag gcgatcatct ccaactctcc      900

gaagagtggt tctatgccca tataatcccg ttcctgggct aa                         942


<210>  222
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-23 (concensusSS-PPT1; Codon optimized IDT)

<400>  222
atggcaagtc cttcctgtct ttggctgctg gctgttgcct tgcttccttg gtcttgtgcg       60

gcgcgggcac tcggccattt ggacccacca gccccactgc ccttggttat atggcatgga      120

atgggagata gttgctgtaa tccactgagc atgggagcca taaagaaaat ggttgagaaa      180

aaaataccgg gaatatatgt tctgagcctg gagataggta agacactcat ggaagacgtt      240

gaaaactcat tttttttgaa cgtgaatagt caagtcacaa cggtctgtca agctctggct      300

aaagatccta agttgcaaca gggttacaat gcgatgggat ttagtcaagg tggacagttc      360

ctgcgggccg tcgcacagag gtgcccgagt ccgccaatga taaatctcat ttcagtaggc      420

ggacaacatc agggcgtgtt cggtcttcct cgctgcccgg gtgagtcttc tcacatttgc      480

gatttcatac gcaaaacact taacgcgggg gcttactcca aggtagttca agaaaggctc      540

gtgcaggccg aatactggca tgatccaatc aaagaagacg tctatagaaa tcactctata      600

ttcttggccg acatcaacca agagcgaggt ataaatgaaa gttacaagaa aaacctcatg      660

gctcttaaaa aatttgttat ggtaaaattt cttaatgact ctatcgttga cccggtcgat      720

agtgagtggt ttgggtttta taggagcgga caggccaaag agacaattcc gttgcaggag      780

acaagtttgt acacgcagga taggcttggt cttaaggaga tggacaacgc gggccaactt      840

gtatttttgg ctactgaagg tgatcacctc caattgtctg aagagtggtt ttatgcgcat      900

attattcctt tcctcggcta a                                                921


<210>  223
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-24 (consensus-PPT1; Codon optimized IDT)

<400>  223
atggcaagcc cttcctgcct ctggttgctt gctgttgctt tgcttccttg gtcttgtgct       60

gcaagagcac ttggccacct tgatcctcct gcacctctcc cgctcgttat atggcacggc      120

atgggggata gctgttgtaa tccactgtca atgggggcta ttaagaaaat ggtggagaag      180

aaaattccgg gaatttatgt gctctccctg gagataggca aaacgcttat ggaagacgtg      240

gagaacagtt tttttcttaa cgtaaattca caggttacca ccgtctgtca aattttggcc      300

aaagatccca aactgcaaca agggtataac gctatgggct tcagtcaagg gggtcaattt      360

ttgagggcgg ttgcgcaacg ctgccctagt ccgcccatga taaacttgat cagtgttggg      420

ggacagcacc agggagtatt tggtctgccg aggtgtccag gcgagtcttc acacatctgt      480

gactttattc gcaagacctt gaacgcgggc gcttattcca aggctgtgca ggaaaggctt      540

gtgcaagcgg aatattggca cgatcctata aaggaagatg tgtatcgcaa ccactctatc      600

ttcctggcgg atatcaatca agaacgagga gtcaatgagt cctacaagaa aaatctgatg      660

gcgcttaaaa agttcgtaat ggtcaagttc ctgaatgaca gcatagtaga tccggtggat      720

tctgaatggt tcggattcta ccggtcagga caggccaagg agacaatccc ccttcaagag      780

acgaccctgt acacacaaga tagattggga ctgaaagaaa tggataaggc cggtcaattg      840

gtcttcttgg ccacagaagg ggaccatctc caactgagtg aagaatggtt ttatgcacat      900

ataattccct tcctggagta a                                                921


<210>  224
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-25 (wt-PPT1 L283C H300C; Codon optimized IDT)

<400>  224
atggcatcac cgggttgcct ctggttgttg gccgttgcgt tgcttccgtg gacatgtgca       60

tcaagagctc ttcaacatct ggatccccca gctcccctgc cgctcgtaat ctggcacggg      120

atgggggatt catgttgtaa cccgttgtca atgggcgcga taaaaaagat ggttgaaaag      180

aagattccag gcatctacgt tctgtccctg gaaatcggta agacactgat ggaagacgtg      240

gagaactcct tctttctcaa cgtcaatagt caggtcacta ccgtctgtca agcattggca      300

aaggacccta aacttcagca ggggtacaat gcgatggggt ttagccaggg cggacagttt      360

cttagagccg tcgcacagcg ctgtccatct cccccgatga ttaaccttat atctgtcggg      420

ggacaacacc agggtgtttt tggtcttcct cgctgtcctg gtgaaagctc ccacatctgt      480

gatttcatac gcaaaacgtt gaacgcagga gcttatagta aagtcgtcca agaacggctt      540

gttcaagcgg agtattggca tgacccaata aaagaagacg tttataggaa tcactctatc      600

ttcttggccg atatcaacca agaacgcgga atcaacgaaa gctacaaaaa gaatcttatg      660

gctctcaaga aatttgttat ggtgaaattc cttaatgact ctatagtaga tcctgtcgat      720

tcagaatggt tcgggttcta caggtctggc caggcgaagg agactattcc cctccaagaa      780

acgtctctct atacacaaga cagactcgga ctgaaagaga tggataatgc gggccagttg      840

gtcttctgcg ctacggaagg cgatcatctc caactctccg aagagtggtt ctatgcctgc      900

ataatcccgt tcctgggcta a                                                921


<210>  225
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-26 (wt-PPT1 G113C L121C; Codon optimized IDT)

<400>  225
atggcatcac cgggttgcct ctggttgttg gccgttgcgt tgcttccgtg gacatgtgca       60

tcaagagctc ttcaacatct ggatccccca gctcccctgc cgctcgtaat ctggcacggg      120

atgggggatt catgttgtaa cccgttgtca atgggcgcga taaaaaagat ggttgaaaag      180

aagattccag gcatctacgt tctgtccctg gaaatcggta agacactgat ggaagacgtg      240

gagaactcct tctttctcaa cgtcaatagt caggtcacta ccgtctgtca agcattggca      300

aaggacccta aacttcagca ggggtacaat gcgatgtgct ttagccaggg cggacagttt      360

tgcagagccg tcgcacagcg ctgtccatct cccccgatga ttaaccttat atctgtcggg      420

ggacaacacc agggtgtttt tggtcttcct cgctgtcctg gtgaaagctc ccacatctgt      480

gatttcatac gcaaaacgtt gaacgcagga gcttatagta aagtcgtcca agaacggctt      540

gttcaagcgg agtattggca tgacccaata aaagaagacg tttataggaa tcactctatc      600

ttcttggccg atatcaacca agaacgcgga atcaacgaaa gctacaaaaa gaatcttatg      660

gctctcaaga aatttgttat ggtgaaattc cttaatgact ctatagtaga tcctgtcgat      720

tcagaatggt tcgggttcta caggtctggc caggcgaagg agactattcc cctccaagaa      780

acgtctctct atacacaaga cagactcgga ctgaaagaga tggataatgc gggccagttg      840

gtcttcttgg ctacggaagg cgatcatctc caactctccg aagagtggtt ctatgcccat      900

ataatcccgt tcctgggcta a                                                921


<210>  226
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-27 (wt-PPT1 A171C A183C; Codon optimized IDT)

<400>  226
atggcatcac cgggttgcct ctggttgttg gccgttgcgt tgcttccgtg gacatgtgca       60

tcaagagctc ttcaacatct ggatccccca gctcccctgc cgctcgtaat ctggcacggg      120

atgggggatt catgttgtaa cccgttgtca atgggcgcga taaaaaagat ggttgaaaag      180

aagattccag gcatctacgt tctgtccctg gaaatcggta agacactgat ggaagacgtg      240

gagaactcct tctttctcaa cgtcaatagt caggtcacta ccgtctgtca agcattggca      300

aaggacccta aacttcagca ggggtacaat gcgatggggt ttagccaggg cggacagttt      360

cttagagccg tcgcacagcg ctgtccatct cccccgatga ttaaccttat atctgtcggg      420

ggacaacacc agggtgtttt tggtcttcct cgctgtcctg gtgaaagctc ccacatctgt      480

gatttcatac gcaaaacgtt gaacgcagga tgctatagta aagtcgtcca agaacggctt      540

gttcaatgcg agtattggca tgacccaata aaagaagacg tttataggaa tcactctatc      600

ttcttggccg atatcaacca agaacgcgga atcaacgaaa gctacaaaaa gaatcttatg      660

gctctcaaga aatttgttat ggtgaaattc cttaatgact ctatagtaga tcctgtcgat      720

tcagaatggt tcgggttcta caggtctggc caggcgaagg agactattcc cctccaagaa      780

acgtctctct atacacaaga cagactcgga ctgaaagaga tggataatgc gggccagttg      840

gtcttcttgg ctacggaagg cgatcatctc caactctccg aagagtggtt ctatgcccat      900

ataatcccgt tcctgggcta a                                                921


<210>  227
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-28 (BiP2aa-PPT1; native human sequence)

<400>  227
atgaaactta gtctcgtcgc agcaatgttg cttctcctgt gggttgccct cctgttgctc       60

agcgcagcta gggctgctgc gtctcgggcg ctgcagcatc tggacccgcc ggcgccgctg      120

ccgttggtga tctggcatgg gatgggagac agctgttgca atcccttaag catgggtgct      180

attaaaaaaa tggtggagaa gaaaatacct ggaatttacg tcttatcttt agagattggg      240

aagaccctga tggaggacgt ggagaacagc ttcttcttga atgtcaattc ccaagtaaca      300

acagtgtgtc aggcacttgc taaggatcct aaattgcagc aaggctacaa tgctatggga      360

ttctcccagg gaggccaatt tctgagggca gtggctcaga gatgcccttc acctcccatg      420

atcaatctga tctcggttgg gggacaacat caaggtgttt ttggactccc tcgatgccca      480

ggagagagct ctcacatctg tgacttcatc cgaaaaacac tgaatgctgg ggcgtactcc      540

aaagttgttc aggaacgcct cgtgcaagcc gaatactggc atgaccccat aaaggaggat      600

gtgtatcgca accacagcat cttcttggca gatataaatc aggagcgggg tatcaatgag      660

tcctacaaga aaaacctgat ggccctgaag aagtttgtga tggtgaaatt cctcaatgat      720

tccattgtgg accctgtaga ttcggagtgg tttggatttt acagaagtgg ccaagccaag      780

gaaaccattc ccttacagga gacctccctg tacacacagg accgcctggg gctaaaggaa      840

atggacaatg caggacagct agtgtttctg gctacagaag gggaccatct tcagttgtct      900

gaagaatggt tttatgccca catcatacca ttccttggat ga                         942


<210>  228
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-101

<400>  228
atgaagctct ccctggtggc cgcgatgctg ctgctgctct gggtggcact gctgctgctc       60

agcgcggcga gggccgccgc gtctagaaca ctgtgcggag gggagcttgt agacactctt      120

cagttcgtgt gtggagatcg cgggttcctc ttctctcgcg gaggtggagg ttctaggggt      180

atactggagg agtgttgttt cagggactgt gacttggcgc tcctcgagac ctattgcgcg      240

acgccagcca ggtccgaagg aggtggtggc agtggaggag gagggagtcg gcctagggca      300

gtcccaaccc aggacccgcc ggcgccgctg ccgttggtga tctggcatgg gatgggagac      360

agctgttgca atcccttaag catgggtgct attaaaaaaa tggtggagaa gaaaatacct      420

ggaatttacg tcttatcttt agagattggg aagaccctga tggaggacgt ggagaacagc      480

ttcttcttga atgtcaattc ccaagtaaca acagtgtgtc aggcacttgc taaggatcct      540

aaattgcagc aaggctacaa tgctatggga ttctcccagg gaggccaatt tctgagggca      600

gtggctcaga gatgcccttc acctcccatg atcaatctga tctcggttgg gggacaacat      660

caaggtgttt ttggactccc tcgatgccca ggagagagct ctcacatctg tgacttcatc      720

cgaaaaacac tgaatgctgg ggcgtactcc aaagttgttc aggaacgcct cgtgcaagcc      780

gaatactggc atgaccccat aaaggaggat gtgtatcgca accacagcat cttcttggca      840

gatataaatc aggagcgggg tatcaatgag tcctacaaga aaaacctgat ggccctgaag      900

aagtttgtga tggtgaaatt cctcaatgat tccattgtgg accctgtaga ttcggagtgg      960

tttggatttt acagaagtgg ccaagccaag gaaaccattc ccttacagga gacctccctg     1020

tacacacagg accgcctggg gctaaaggaa atggacaatg caggacagct agtgtttctg     1080

gctacagaag gggaccatct tcagttgtct gaagaatggt tttatgccca catcatacca     1140

ttccttggat ga                                                         1152


<210>  229
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-31 (BiP1-vIGF2-PPT1; native human sequence)

<400>  229
atgaagctca gtctcgtggc agctatgctc ctcctgctgt ccctggttgc ggcaatgttg       60

ctcttgctga gcgccgcgag agcaagtcgc acgttgtgtg gaggtgaact cgtcgacacc      120

cttcagttcg tatgtggaga tcgcggtttc ctcttctcac gcccagcttc cagagtttcc      180

cgaagatcac gaggaatagt tgaggagtgc tgttttcggt cttgtgatct ggctctcctc      240

gagacttatt gtgctacgcc ggcccgctct gaaggaggtg gtggcagtgg aggaggaggg      300

agtcggccta gggcagtccc aacccaggac ccgccggcgc cgctgccgtt ggtgatctgg      360

catgggatgg gagacagctg ttgcaatccc ttaagcatgg gtgctattaa aaaaatggtg      420

gagaagaaaa tacctggaat ttacgtctta tctttagaga ttgggaagac cctgatggag      480

gacgtggaga acagcttctt cttgaatgtc aattcccaag taacaacagt gtgtcaggca      540

cttgctaagg atcctaaatt gcagcaaggc tacaatgcta tgggattctc ccagggaggc      600

caatttctga gggcagtggc tcagagatgc ccttcacctc ccatgatcaa tctgatctcg      660

gttgggggac aacatcaagg tgtttttgga ctccctcgat gcccaggaga gagctctcac      720

atctgtgact tcatccgaaa aacactgaat gctggggcgt actccaaagt tgttcaggaa      780

cgcctcgtgc aagccgaata ctggcatgac cccataaagg aggatgtgta tcgcaaccac      840

agcatcttct tggcagatat aaatcaggag cggggtatca atgagtccta caagaaaaac      900

ctgatggccc tgaagaagtt tgtgatggtg aaattcctca atgattccat tgtggaccct      960

gtagattcgg agtggtttgg attttacaga agtggccaag ccaaggaaac cattccctta     1020

caggagacct ccctgtacac acaggaccgc ctggggctaa aggaaatgga caatgcagga     1080

cagctagtgt ttctggctac agaaggggac catcttcagt tgtctgaaga atggttttat     1140

gcccacatca taccattcct tggatga                                         1167


<210>  230
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-32 (wt-PPT1-vIGF2-32; native human sequence)

<400>  230
atggcgtcgc ccggctgcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggacccgccg gcgccgctgc cgttggtgat ctggcatggg      120

atgggagaca gctgttgcaa tcccttaagc atgggtgcta ttaaaaaaat ggtggagaag      180

aaaatacctg gaatttacgt cttatcttta gagattggga agaccctgat ggaggacgtg      240

gagaacagct tcttcttgaa tgtcaattcc caagtaacaa cagtgtgtca ggcacttgct      300

aaggatccta aattgcagca aggctacaat gctatgggat tctcccaggg aggccaattt      360

ctgagggcag tggctcagag atgcccttca cctcccatga tcaatctgat ctcggttggg      420

ggacaacatc aaggtgtttt tggactccct cgatgcccag gagagagctc tcacatctgt      480

gacttcatcc gaaaaacact gaatgctggg gcgtactcca aagttgttca ggaacgcctc      540

gtgcaagccg aatactggca tgaccccata aaggaggatg tgtatcgcaa ccacagcatc      600

ttcttggcag atataaatca ggagcggggt atcaatgagt cctacaagaa aaacctgatg      660

gccctgaaga agtttgtgat ggtgaaattc ctcaatgatt ccattgtgga ccctgtagat      720

tcggagtggt ttggatttta cagaagtggc caagccaagg aaaccattcc cttacaggag      780

acctccctgt acacacagga ccgcctgggg ctaaaggaaa tggacaatgc aggacagcta      840

gtgtttctgg ctacagaagg ggaccatctt cagttgtctg aagaatggtt ttatgcccac      900

atcataccat tccttggaag acctagagca gtgcctacgc agggagggag tgggagtgga      960

tccacttcat cctctagaac actgtgcgga ggggagcttg tagacactct tcagttcgtg     1020

tgtggagatc gcgggttcct cttctctcgc ggaggtggag gttctagggg tatactggag     1080

gagtgttgtt tcagggagtg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc     1140

aggtccgaat ga                                                         1152


<210>  231
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-33 (wt-PPT1-vIGF2-8Q; native human sequence)

<400>  231
atggcgtcgc ccggctgcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggacccgccg gcgccgctgc cgttggtgat ctggcatggg      120

atgggagaca gctgttgcaa tcccttaagc atgggtgcta ttaaaaaaat ggtggagaag      180

aaaatacctg gaatttacgt cttatcttta gagattggga agaccctgat ggaggacgtg      240

gagaacagct tcttcttgaa tgtcaattcc caagtaacaa cagtgtgtca ggcacttgct      300

aaggatccta aattgcagca aggctacaat gctatgggat tctcccaggg aggccaattt      360

ctgagggcag tggctcagag atgcccttca cctcccatga tcaatctgat ctcggttggg      420

ggacaacatc aaggtgtttt tggactccct cgatgcccag gagagagctc tcacatctgt      480

gacttcatcc gaaaaacact gaatgctggg gcgtactcca aagttgttca ggaacgcctc      540

gtgcaagccg aatactggca tgaccccata aaggaggatg tgtatcgcaa ccacagcatc      600

ttcttggcag atataaatca ggagcggggt atcaatgagt cctacaagaa aaacctgatg      660

gccctgaaga agtttgtgat ggtgaaattc ctcaatgatt ccattgtgga ccctgtagat      720

tcggagtggt ttggatttta cagaagtggc caagccaagg aaaccattcc cttacaggag      780

acctccctgt acacacagga ccgcctgggg ctaaaggaaa tggacaatgc aggacagcta      840

gtgtttctgg ctacagaagg ggaccatctt cagttgtctg aagaatggtt ttatgcccac      900

atcataccat tccttggaag acctagagca gtgcctacgc agggagggag tgggagtgga      960

tccacttcat cctctagaac actgtgcgga ggggagcttg tagacactct tcagttcgtg     1020

tgtggagatc gcgggttcct cttctctcgc cccgcttcca gagtttcacg gaggtctagg     1080

ggtatagtag aggagtgttg tttcagggag tgtgacttgg cgctcctcga gacctattgc     1140

gcgacgccag ccaggtccga atga                                            1164


<210>  232
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-34 (wt-PPT1-vIGF2-8Q; Codon optimized  GENEius)

<400>  232
atggcctccc caggctgctt atggttgctg gccgtagcac ttttaccatg gacatgtgct       60

agtcgagctt tacaacactt agacccgcca gcgcctcttc ctttagttat ctggcacggc      120

atgggcgact cgtgttgtaa cccgctcagt atgggtgcca taaagaagat ggtggagaag      180

aaaattcccg gaatctatgt gcttagcctc gaaatcggca aaacacttat ggaggacgta      240

gagaactcat tcttcctgaa tgtaaatagc caagtcacca cggtatgtca agctctagcg      300

aaggacccta aactccagca ggggtataac gcaatgggat tttctcaggg cggccagttt      360

ctgcgtgctg tcgcacagcg ttgcccttct ccgcctatga taaacttaat ttccgtagga      420

gggcaacacc aaggggtatt cggcttaccg aggtgtccag gcgaatcttc acatatatgc      480

gacttcatcc gaaagaccct taatgccggg gcctattcca aggtggtaca ggaacggttg      540

gtgcaagctg agtattggca cgaccctata aaggaagatg tgtatcggaa tcactcaatc      600

tttcttgcgg atataaatca agagcgcggc attaacgaga gctacaagaa gaacctcatg      660

gctcttaaga aattcgtcat ggtcaaattc ctcaacgaca gtatagttga tcccgtcgat      720

tcggagtggt ttggattcta ccgctctggg caagccaaag agaccatacc actacaggaa      780

acatcgctat atacccaaga tcgcttgggt ttgaaagaaa tggataacgc cggtcagctt      840

gtgttcttag cgacagaggg tgatcatctc cagctgtcgg aagaatggtt ctatgcccac      900

ataatacctt tccttggacg accccgtgcg gtcccaacgc agggtggatc aggtagcggc      960

tcaactagtt ccagccgtac gttgtgcggc ggagaactag tagacactct tcaattcgtt     1020

tgtggggatc ggggcttcct cttcagcagg ccagcgtcac gcgtgtcgcg tcggagccga     1080

ggtatagtgg aagaatgctg cttccgcgaa tgtgatctag cactccttga aacctactgc     1140

gcgacgcctg cccgaagtga atga                                            1164


<210>  233
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-35 (wt-PPT1-vIGF2-8Q; Codon optimized COOL)

<400>  233
atggcttccc ctggctgcct gtggctgctc gctgtggccc tcctgccctg gacctgtgct       60

tctcgggccc ttcagcatct ggaccctcca gcccccctcc ccttggtcat ctggcacggc      120

atgggcgaca gctgctgcaa ccctctgtcc atgggggcca tcaagaaaat ggttgagaag      180

aagatcccag gcatctacgt gctgagcctg gaaattggca agacactgat ggaggatgtg      240

gaaaacagct tcttcctgaa tgtgaactcc caggtgacca ccgtgtgcca ggctctggcc      300

aaagatccca agctgcagca gggctacaat gccatgggat tcagccaggg gggccagttt      360

ctgcgggctg ttgcccagag gtgccccagc ccccccatga tcaatctcat ctctgtgggc      420

gggcagcacc agggtgtgtt tggcctgcct cgctgccctg gagaaagcag ccacatttgt      480

gatttcatca ggaagacctt aaatgctgga gcctacagca aggtggtcca ggaaaggctg      540

gtgcaggcag agtactggca tgaccccatc aaagaggacg tgtacagaaa ccacagcatc      600

ttcctggctg acatcaacca ggagagagga attaatgaga gctacaagaa gaacctcatg      660

gccttgaaaa agtttgtgat ggtgaagttc ttgaatgact ccatcgtgga tcctgtggac      720

agtgaatggt ttgggttcta ccgctctgga caggccaagg aaaccatccc cctgcaagaa      780

acatccctgt acacccagga ccgcctgggg ctgaaggaga tggacaacgc cggccaactg      840

gtcttccttg ccacagaagg agaccacctg cagctgtctg aggagtggtt ctatgcccac      900

atcatcccct tcctgggccg gcccagggcc gtgcccacac agggaggcag tggcagcggc      960

tccaccagct ccagcaggac cctgtgtggc ggcgagctgg ttgacaccct ccagttcgtg     1020

tgtggggaca gaggcttcct cttctccagg cccgccagcc gggtgagccg ccgctcccgg     1080

ggcattgtgg aggaatgttg cttccgggag tgtgacctgg ccctgctgga gacctactgt     1140

gccacccctg cccggagtga gtga                                            1164


<210>  234
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-101

<400>  234
atgaagctct ccctggtggc cgcgatgctg ctgctgctct gggtggcact gctgctgctc       60

agcgcggcga gggccgccgc gtctagaaca ctgtgcggag gggagcttgt agacactctt      120

cagttcgtgt gtggagatcg cgggttcctc ttctctcgcg gaggtggagg ttctaggggt      180

atactggagg agtgttgttt cagggactgt gacttggcgc tcctcgagac ctattgcgcg      240

acgccagcca ggtccgaagg aggtggtggc agtggaggag gagggagtcg gcctagggca      300

gtcccaaccc aggacccgcc ggcgccgctg ccgttggtga tctggcatgg gatgggagac      360

agctgttgca atcccttaag catgggtgct attaaaaaaa tggtggagaa gaaaatacct      420

ggaatttacg tcttatcttt agagattggg aagaccctga tggaggacgt ggagaacagc      480

ttcttcttga atgtcaattc ccaagtaaca acagtgtgtc aggcacttgc taaggatcct      540

aaattgcagc aaggctacaa tgctatggga ttctcccagg gaggccaatt tctgagggca      600

gtggctcaga gatgcccttc acctcccatg atcaatctga tctcggttgg gggacaacat      660

caaggtgttt ttggactccc tcgatgccca ggagagagct ctcacatctg tgacttcatc      720

cgaaaaacac tgaatgctgg ggcgtactcc aaagttgttc aggaacgcct cgtgcaagcc      780

gaatactggc atgaccccat aaaggaggat gtgtatcgca accacagcat cttcttggca      840

gatataaatc aggagcgggg tatcaatgag tcctacaaga aaaacctgat ggccctgaag      900

aagtttgtga tggtgaaatt cctcaatgat tccattgtgg accctgtaga ttcggagtgg      960

tttggatttt acagaagtgg ccaagccaag gaaaccattc ccttacagga gacctccctg     1020

tacacacagg accgcctggg gctaaaggaa atggacaatg caggacagct agtgtttctg     1080

gctacagaag gggaccatct tcagttgtct gaagaatggt tttatgccca catcatacca     1140

ttccttggat ga                                                         1152


<210>  235
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-104

<400>  235
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggacccgccg gcgccgctgc cgttggtgat ctggcatggg      120

atgggagaca gctgttgcaa tcccttaagc atgggtgcta ttaaaaaaat ggtggagaag      180

aaaatacctg gaatttacgt cttatcttta gagattggga agaccctgat ggaggacgtg      240

gagaacagct tcttcttgaa tgtcaattcc caagtaacaa cagtgtgtca ggcacttgct      300

aaggatccta aattgcagca aggctacaat gctatgggat tctcccaggg aggccaattt      360

ctgagggcag tggctcagag atgcccttca cctcccatga tcaatctgat ctcggttggg      420

ggacaacatc aaggtgtttt tggactccct cgatgcccag gagagagctc tcacatctgt      480

gacttcatcc gaaaaacact gaatgctggg gcgtactcca aagttgttca ggaacgcctc      540

gtgcaagccg aatactggca tgaccccata aaggaggatg tgtatcgcaa ccacagcatc      600

ttcttggcag atataaatca ggagcggggt atcaatgagt cctacaagaa aaacctgatg      660

gccctgaaga agtttgtgat ggtgaaattc ctcaatgatt ccattgtgga ccctgtagat      720

tcggagtggt ttggatttta cagaagtggc caagccaagg aaaccattcc cttacaggag      780

acctccctgt acacacagga ccgcctgggg ctaaaggaaa tggacaatgc aggacagcta      840

gtgtttctgg ctacagaagg ggaccatctt cagttgtctg aagaatggtt ttatgcccac      900

atcataccat tccttggaag acctagagca gtgcctacgc agggagggag tgggagtgga      960

tccacttcat cctctagaac actgtgcgga ggggagcttg tagacactct tcagttcgtg     1020

tgtggagatc gcgggttcct cttctctcgc ggaggtggag gttctagggg tatactggag     1080

gagtgttgtt tcagggagtg tgacttggcg ctcctcgaga cctattgcgc gacgccagcc     1140

aggtccgaat ga                                                         1152


<210>  236
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT-112

<400>  236
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggccgcgtct agaacactgt gcggagggga gcttgtagac      120

actcttcagt tcgtgtgtgg agatcgcggg ttcctcttct ctcgcggagg tggaggttct      180

aggggtatac tggaggagtg ttgtttcagg gactgtgact tggcgctcct cgagacctat      240

tgcgcgacgc cagccaggtc cgaaggaggt ggtggcagtg gaggaggagg gagtcggcct      300

agggcagtcc caacccagga cccgccggcg ccgctgccgt tggtgatctg gcatgggatg      360

ggagacagct gttgcaatcc cttaagcatg ggtgctatta aaaaaatggt ggagaagaaa      420

atacctggaa tttacgtctt atctttagag attgggaaga ccctgatgga ggacgtggag      480

aacagcttct tcttgaatgt caattcccaa gtaacaacag tgtgtcaggc acttgctaag      540

gatcctaaat tgcagcaagg ctacaatgct atgggattct cccagggagg ccaatttctg      600

agggcagtgg ctcagagatg cccttcacct cccatgatca atctgatctc ggttggggga      660

caacatcaag gtgtttttgg actccctcga tgcccaggag agagctctca catctgtgac      720

ttcatccgaa aaacactgaa tgctggggcg tactccaaag ttgttcagga acgcctcgtg      780

caagccgaat actggcatga ccccataaag gaggatgtgt atcgcaacca cagcatcttc      840

ttggcagata taaatcagga gcggggtatc aatgagtcct acaagaaaaa cctgatggcc      900

ctgaagaagt ttgtgatggt gaaattcctc aatgattcca ttgtggaccc tgtagattcg      960

gagtggtttg gattttacag aagtggccaa gccaaggaaa ccattccctt acaggagacc     1020

tccctgtaca cacaggaccg cctggggcta aaggaaatgg acaatgcagg acagctagtg     1080

tttctggcta cagaagggga ccatcttcag ttgtctgaag aatggtttta tgcccacatc     1140

ataccattcc ttggatga                                                   1158


<210>  237
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT-114

<400>  237
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggccgcgtct agaacactgt gcggagggga gcttgtagac      120

actcttcagt tcgtgtgtgg agatcgcggg ttcctcttct ctcgcggagg tggaggttct      180

aggggtatac tggaggagtg ttgtttcagg gagtgtgact tggcgctcct cgagacctat      240

tgcgcgacgc cagccaggtc cgaaggaggt ggtggcagtg gaggaggagg gagtcggcct      300

agggcagtcc caacccagga cccgccggcg ccgctgccgt tggtgatctg gcatgggatg      360

ggagacagct gttgcaatcc cttaagcatg ggtgctatta aaaaaatggt ggagaagaaa      420

atacctggaa tttacgtctt atctttagag attgggaaga ccctgatgga ggacgtggag      480

aacagcttct tcttgaatgt caattcccaa gtaacaacag tgtgtcaggc acttgctaag      540

gatcctaaat tgcagcaagg ctacaatgct atgggattct cccagggagg ccaatttctg      600

agggcagtgg ctcagagatg cccttcacct cccatgatca atctgatctc ggttggggga      660

caacatcaag gtgtttttgg actccctcga tgcccaggag agagctctca catctgtgac      720

ttcatccgaa aaacactgaa tgctggggcg tactccaaag ttgttcagga acgcctcgtg      780

caagccgaat actggcatga ccccataaag gaggatgtgt atcgcaacca cagcatcttc      840

ttggcagata taaatcagga gcggggtatc aatgagtcct acaagaaaaa cctgatggcc      900

ctgaagaagt ttgtgatggt gaaattcctc aatgattcca ttgtggaccc tgtagattcg      960

gagtggtttg gattttacag aagtggccaa gccaaggaaa ccattccctt acaggagacc     1020

tccctgtaca cacaggaccg cctggggcta aaggaaatgg acaatgcagg acagctagtg     1080

tttctggcta cagaagggga ccatcttcag ttgtctgaag aatggtttta tgcccacatc     1140

ataccattcc ttggatga                                                   1158


<210>  238
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-115

<400>  238
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggctgccgac ccgccggcgc cgctgccgtt ggtgatctgg      120

catgggatgg gagacagctg ttgcaatccc ttaagcatgg gtgctattaa aaaaatggtg      180

gagaagaaaa tacctggaat ttacgtctta tctttagaga ttgggaagac cctgatggag      240

gacgtggaga acagcttctt cttgaatgtc aattcccaag taacaacagt gtgtcaggca      300

cttgctaagg atcctaaatt gcagcaaggc tacaatgcta tgggattctc ccagggaggc      360

caatttctga gggcagtggc tcagagatgc ccttcacctc ccatgatcaa tctgatctcg      420

gttgggggac aacatcaagg tgtttttgga ctccctcgat gcccaggaga gagctctcac      480

atctgtgact tcatccgaaa aacactgaat gctggggcgt actccaaagt tgttcaggaa      540

cgcctcgtgc aagccgaata ctggcatgac cccataaagg aggatgtgta tcgcaaccac      600

agcatcttct tggcagatat aaatcaggag cggggtatca atgagtccta caagaaaaac      660

ctgatggccc tgaagaagtt tgtgatggtg aaattcctca atgattccat tgtggaccct      720

gtagattcgg agtggtttgg attttacaga agtggccaag ccaaggaaac cattccctta      780

caggagacct ccctgtacac acaggaccgc ctggggctaa aggaaatgga caatgcagga      840

cagctagtgt ttctggctac agaaggggac catcttcagt tgtctgaaga atggttttat      900

gcccacatca taccattcct tggaagacct agagcagtgc ctacgcaggg agggagtggg      960

agtggatcca cttcatcctc tagaacactg tgcggagggg agcttgtaga cactcttcag     1020

ttcgtgtgtg gagatcgcgg gttcctcttc tctcgcggag gtggaggttc taggggtata     1080

ctggaggagt gttgtttcag ggagtgtgac ttggcgctcc tcgagaccta ttgcgcgacg     1140

ccagccaggt ccgaatga                                                   1158


<210>  239
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT-116

<400>  239
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggctgccgac ccgccggcgc cgctgccgtt ggtgatctgg      120

catgggatgg gagacagctg ttgcaatccc ttaagcatgg gtgctattaa aaaaatggtg      180

gagaagaaaa tacctggaat ttacgtctta tctttagaga ttgggaagac cctgatggag      240

gacgtggaga acagcttctt cttgaatgtc aattcccaag taacaacagt gtgtcaggca      300

cttgctaagg atcctaaatt gcagcaaggc tacaatgcta tgggattctc ccagggaggc      360

caatttctga gggcagtggc tcagagatgc ccttcacctc ccatgatcaa tctgatctcg      420

gttgggggac aacatcaagg tgtttttgga ctccctcgat gcccaggaga gagctctcac      480

atctgtgact tcatccgaaa aacactgaat gctggggcgt actccaaagt tgttcaggaa      540

cgcctcgtgc aagccgaata ctggcatgac cccataaagg aggatgtgta tcgcaaccac      600

agcatcttct tggcagatat aaatcaggag cggggtatca atgagtccta caagaaaaac      660

ctgatggccc tgaagaagtt tgtgatggtg aaattcctca atgattccat tgtggaccct      720

gtagattcgg agtggtttgg attttacaga agtggccaag ccaaggaaac cattccctta      780

caggagacct ccctgtacac acaggaccgc ctggggctaa aggaaatgga caatgcagga      840

cagctagtgt ttctggctac agaaggggac catcttcagt tgtctgaaga atggttttat      900

gcccacatca taccattcct tggaagacct agagcagtgc ctacgcaggg agggggtggc      960

agtggcagtg gaggcggcgg ttcctctaga acactgtgcg gaggggagct tgtagacact     1020

cttcagttcg tgtgtggaga tcgcgggttc ctcttctctc gcggaggtgg aggttctagg     1080

ggtatactgg aggagtgttg tttcagggag tgtgacttgg cgctcctcga gacctattgc     1140

gcgacgccag ccaggtccga atga                                            1164


<210>  240
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT1-117

<400>  240
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggacccgccg gcgccgctgc cgttggtgat ctggcatggg      120

atgggagaca gctgttgcaa tcccttaagc atgggtgcta ttaaaaaaat ggtggagaag      180

aaaatacctg gaatttacgt cttatcttta gagattggga agaccctgat ggaggacgtg      240

gagaacagct tcttcttgaa tgtcaattcc caagtaacaa cagtgtgtca ggcacttgct      300

aaggatccta aattgcagca aggctacaat gctatgggat tctcccaggg aggccaattt      360

ctgagggcag tggctcagag atgcccttca cctcccatga tcaatctgat ctcggttggg      420

ggacaacatc aaggtgtttt tggactccct cgatgcccag gagagagctc tcacatctgt      480

gacttcatcc gaaaaacact gaatgctggg gcgtactcca aagttgttca ggaacgcctc      540

gtgcaagccg aatactggca tgaccccata aaggaggatg tgtatcgcaa ccacagcatc      600

ttcttggcag atataaatca ggagcggggt atcaatgagt cctacaagaa aaacctgatg      660

gccctgaaga agtttgtgat ggtgaaattc ctcaatgatt ccattgtgga ccctgtagat      720

tcggagtggt ttggatttta cagaagtggc caagccaagg aaaccattcc cttacaggag      780

acctccctgt acacacagga ccgcctgggg ctaaaggaaa tggacaatgc aggacagcta      840

gtgtttctgg ctacagaagg ggaccatctt cagttgtctg aagaatggtt ttatgcccac      900

atcataccat tccttggaag acctagagca gtgcctacgc agggaggggg tggcagtggc      960

agtggaggcg gcggttcctc tagaacactg tgcggagggg agcttgtaga cactcttcag     1020

ttcgtgtgtg gagatcgcgg gttcctcttc tctcgcggag gtggaggttc taggggtata     1080

ctggaggagt gttgtttcag ggagtgtgac ttggcgctcc tcgagaccta ttgcgcgacg     1140

ccagccaggt ccgaatga                                                   1158


<210>  241
<211>  1158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PPT-118

<400>  241
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggctgccgac ccgccggcgc cgctgccgtt ggtgatctgg      120

catgggatgg gagacagctg ttgcaatccc ttaagcatgg gtgctattaa aaaaatggtg      180

gagaagaaaa tacctggaat ttacgtctta tctttagaga ttgggaagac cctgatggag      240

gacgtggaga acagcttctt cttgaatgtc aattcccaag taacaacagt gtgtcaggca      300

cttgctaagg atcctaaatt gcagcaaggc tacaatgcta tgggattctc ccagggaggc      360

caatttctga gggcagtggc tcagagatgc ccttcacctc ccatgatcaa tctgatctcg      420

gttgggggac aacatcaagg tgtttttgga ctccctcgat gcccaggaga gagctctcac      480

atctgtgact tcatccgaaa aacactgaat gctggggcgt actccaaagt tgttcaggaa      540

cgcctcgtgc aagccgaata ctggcatgac cccataaagg aggatgtgta tcgcaaccac      600

agcatcttct tggcagatat aaatcaggag cggggtatca atgagtccta caagaaaaac      660

ctgatggccc tgaagaagtt tgtgatggtg aaattcctca atgattccat tgtggaccct      720

gtagattcgg agtggtttgg attttacaga agtggccaag ccaaggaaac cattccctta      780

caggagacct ccctgtacac acaggaccgc ctggggctaa aggaaatgga caatgcagga      840

cagctagtgt ttctggctac agaaggggac catcttcagt tgtctgaaga atggttttat      900

gcccacatca taccattcct tggaagacct agagcagtgc ctacgcaggg agggggtggc      960

agtggaggcg gcggttcctc tagaacactg tgcggagggg agcttgtaga cactcttcag     1020

ttcgtgtgtg gagatcgcgg gttcctcttc tctcgcggag gtggaggttc taggggtata     1080

ctggaggagt gttgtttcag ggagtgtgac ttggcgctcc tcgagaccta ttgcgcgacg     1140

ccagccaggt ccgaatga                                                   1158


<210>  242
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiP2AA

<400>  242
atgaagctct ccctggtggc cgcgatgctg ctgctgctct gggtggcact gctgctgctc       60

agcgcggcga gggccgccgc g                                                 81


<210>  243
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  eSP C6S

<400>  243
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct g                                                 81


<210>  244
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  eSP C6S AA (used in PPT1-112 and PPT1-114)

<400>  244
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggccgcg                                           87


<210>  245
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  eSP C6S AA (used in PPT1-115, PPT1-116, and PPT1-118) - different
       codon usage for AA portion

<400>  245
atggcgtcgc ccggcagcct gtggctcttg gctgtggctc tcctgccatg gacctgcgct       60

tctcgggcgc tgcagcatct ggctgcc                                           87


<210>  246
<211>  2295
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WT NAGLU-HPC4

<400>  246
atggaggccg tggccgtggc cgccgccgtg ggcgtgctgc tgctggccgg cgccggcggc       60

gccgccggcg acgaggcccg ggaggccgcc gccgtgcggg ccctggtggc ccggctgctg      120

ggccccggcc ccgccgccga cttcagcgtt agcgtggagc gggccctggc cgccaagccc      180

ggcctggaca cctacagcct gggcggcggc ggcgccgccc gggtgcgggt gcggggcagc      240

accggcgtgg ccgccgccgc cggcctgcac cggtatctgc gggacttctg cggctgccac      300

gtggcctgga gcggcagcca gctgcggctg ccccggcccc tgcccgccgt gcccggcgag      360

ctgaccgagg ccacccccaa ccggtatcgg tactaccaga acgtgtgcac ccagagctac      420

agcttcgtgt ggtgggactg ggcccggtgg gagcgggaga tcgactggat ggccctgaac      480

ggcatcaacc tggccctggc ctggagcggc caggaggcca tctggcagcg ggtgtacctg      540

gccctgggcc tgacccaggc cgagatcaac gagttcttca ccggccccgc cttcctggcc      600

tggggccgga tgggcaacct gcacacctgg gacggccccc tgcctccaag ctggcacatc      660

aagcagctgt acctgcagca ccgggtgctg gaccagatgc ggagcttcgg catgaccccc      720

gtgctgcccg ccttcgccgg ccacgtgccc gaggccgtga cccgggtgtt cccccaagtt      780

aacgtgacca agatgggcag ctggggccac ttcaactgca gctacagctg cagcttcctg      840

ctggcccccg aggaccccat cttccccatc atcggcagcc tgttcctgcg ggagctgatc      900

aaggagttcg gcaccgacca catctacggc gccgacacct tcaacgagat gcagcctcca      960

agcagcgagc ccagctacct ggccgccgcc accaccgccg tgtacgaggc catgaccgcc     1020

gtggacaccg aggccgtgtg gctgctgcag ggctggctgt tccagcacca gccccagttc     1080

tggggacctg cccagatccg ggccgtgctg ggcgccgtgc ctagaggacg gctgctggtg     1140

ctggacctgt tcgccgagag ccagcccgtg tacacccgga ccgccagctt ccagggccag     1200

cccttcatct ggtgcatgct gcacaacttc ggcggcaacc acggcctgtt cggcgccctg     1260

gaggccgtga acggcggccc cgaggccgcc cggctgttcc ccaacagcac catggtgggc     1320

accggcatgg cccccgaggg catcagccag aacgaggtgg tgtacagcct gatggccgag     1380

ctgggctggc ggaaggaccc cgtgcccgac ctggccgcct gggtgaccag cttcgccgcc     1440

cggcggtacg gcgtgagcca ccccgacgcc ggcgccgcct ggcggctgct gctgcggagc     1500

gtgtacaact gcagcggcga ggcctgccgg ggccacaacc ggagccccct ggtgcggcgg     1560

cccagcctgc agatgaacac cagcatctgg tacaaccgga gcgacgtgtt cgaggcctgg     1620

cggctgctgc tgaccagcgc ccccagcctg gccaccagcc ccgccttcag atacgacctg     1680

ctggacctga cccggcaggc cgtgcaggag ctggtgagcc tgtactacga ggaggcccgg     1740

agcgcctacc tgagcaagga gctggccagc ctgctgcggg ccggcggcgt gctggcctac     1800

gagctgctgc ccgccctgga cgaggtgctg gccagcgaca gccggttcct gctgggcagc     1860

tggctggagc aggcccgggc cgccgccgtg agcgaggccg aggccgactt ctacgagcag     1920

aacagccggt atcagctgac cctgtgggga cctgagggca acatcctgga ctacgccaac     1980

aagcagctgg ccggcctggt ggccaactac tacaccccaa ggtggcggct gttcctggag     2040

gccctggtgg acagcgtggc ccagggcatc cccttccagc agcaccagtt cgacaagaac     2100

gtgttccagc tggagcaggc cttcgtgctg agcaagcagc ggtatcccag ccagcctaga     2160

ggagacaccg tggacctggc caagaagatc ttcctgaagt actacccccg gtgggtggcc     2220

ggcagctggg gacttgaggt actgttccaa gggcccgagg accaggtaga cccacgactc     2280

attgatggaa aatag                                                      2295


<210>  247
<211>  2544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-NAGLU-HPC4

<400>  247
atggaggctg tggctgtggc agctgcggtg ggggtccttc tcctggccgg ggccgggggc       60

gcggcaggcg acgcttctag gacgttgtgt ggtggggaac ttgtcgacac actgcagttt      120

gtctgcggcg accgaggatt tcttttttcc aggcctgcct caagagtatc taggaggtcc      180

cgcggtattg ttgaagagtg ctgttttagg tcatgcgacc ttgcgttgtt ggagacatat      240

tgtgctaccc ctgcacgctc tgaaggtgga ggtggttcag gtggtggagg ttccaggcca      300

agggcggtcc ctactcaggc cgaggcccgg gaggccgccg ccgtgcgggc cctggtggcc      360

cggctgctgg gccccggccc cgccgccgac ttcagcgtta gcgtggagcg ggccctggcc      420

gccaagcccg gcctggacac ctacagcctg ggcggcggcg gcgccgcccg ggtgcgggtg      480

cggggcagca ccggcgtggc cgccgccgcc ggcctgcacc ggtatctgcg ggacttctgc      540

ggctgccacg tggcctggag cggcagccag ctgcggctgc cccggcccct gcccgccgtg      600

cccggcgagc tgaccgaggc cacccccaac cggtatcggt actaccagaa cgtgtgcacc      660

cagagctaca gcttcgtgtg gtgggactgg gcccggtggg agcgggagat cgactggatg      720

gccctgaacg gcatcaacct ggccctggcc tggagcggcc aggaggccat ctggcagcgg      780

gtgtacctgg ccctgggcct gacccaggcc gagatcaacg agttcttcac cggccccgcc      840

ttcctggcct ggggccggat gggcaacctg cacacctggg acggccccct gcctccaagc      900

tggcacatca agcagctgta cctgcagcac cgggtgctgg accagatgcg gagcttcggc      960

atgacccccg tgctgcccgc cttcgccggc cacgtgcccg aggccgtgac ccgggtgttc     1020

ccccaagtta acgtgaccaa gatgggcagc tggggccact tcaactgcag ctacagctgc     1080

agcttcctgc tggcccccga ggaccccatc ttccccatca tcggcagcct gttcctgcgg     1140

gagctgatca aggagttcgg caccgaccac atctacggcg ccgacacctt caacgagatg     1200

cagcctccaa gcagcgagcc cagctacctg gccgccgcca ccaccgccgt gtacgaggcc     1260

atgaccgccg tggacaccga ggccgtgtgg ctgctgcagg gctggctgtt ccagcaccag     1320

ccccagttct ggggacctgc ccagatccgg gccgtgctgg gcgccgtgcc tagaggacgg     1380

ctgctggtgc tggacctgtt cgccgagagc cagcccgtgt acacccggac cgccagcttc     1440

cagggccagc ccttcatctg gtgcatgctg cacaacttcg gcggcaacca cggcctgttc     1500

ggcgccctgg aggccgtgaa cggcggcccc gaggccgccc ggctgttccc caacagcacc     1560

atggtgggca ccggcatggc ccccgagggc atcagccaga acgaggtggt gtacagcctg     1620

atggccgagc tgggctggcg gaaggacccc gtgcccgacc tggccgcctg ggtgaccagc     1680

ttcgccgccc ggcggtacgg cgtgagccac cccgacgccg gcgccgcctg gcggctgctg     1740

ctgcggagcg tgtacaactg cagcggcgag gcctgccggg gccacaaccg gagccccctg     1800

gtgcggcggc ccagcctgca gatgaacacc agcatctggt acaaccggag cgacgtgttc     1860

gaggcctggc ggctgctgct gaccagcgcc cccagcctgg ccaccagccc cgccttcaga     1920

tacgacctgc tggacctgac ccggcaggcc gtgcaggagc tggtgagcct gtactacgag     1980

gaggcccgga gcgcctacct gagcaaggag ctggccagcc tgctgcgggc cggcggcgtg     2040

ctggcctacg agctgctgcc cgccctggac gaggtgctgg ccagcgacag ccggttcctg     2100

ctgggcagct ggctggagca ggcccgggcc gccgccgtga gcgaggccga ggccgacttc     2160

tacgagcaga acagccggta tcagctgacc ctgtggggac ctgagggcaa catcctggac     2220

tacgccaaca agcagctggc cggcctggtg gccaactact acaccccaag gtggcggctg     2280

ttcctggagg ccctggtgga cagcgtggcc cagggcatcc ccttccagca gcaccagttc     2340

gacaagaacg tgttccagct ggagcaggcc ttcgtgctga gcaagcagcg gtatcccagc     2400

cagcctagag gagacaccgt ggacctggcc aagaagatct tcctgaagta ctacccccgg     2460

tgggtggccg gcagctgggg acttgaggta ctgttccaag ggcccgagga ccaggtagac     2520

ccacgactca ttgatggaaa atag                                            2544


<210>  248
<211>  2544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-17-NAGLU-HPC4

<400>  248
atggaggctg tggctgtggc agctgcggtg ggggtccttc tcctggccgg ggccgggggc       60

gcggcaggcg acgctagcag aacactttgt ggcggagagc tggtggacac cctgcagttt      120

gtgtgtggcg acagaggctt cctgttcagc agacctgcat ccagagttag caggcggtcc      180

agaggaatcg tggaagagtg ctgcttcaga gaatgcgatc tggccctgct ggaaacctac      240

tgtgccacac cagccagatc tgaaggtgga ggtggttcag gtggtggagg ttccaggcca      300

agggcggtcc ctactcaggc cgaggcccgg gaggccgccg ccgtgcgggc cctggtggcc      360

cggctgctgg gccccggccc cgccgccgac ttcagcgtta gcgtggagcg ggccctggcc      420

gccaagcccg gcctggacac ctacagcctg ggcggcggcg gcgccgcccg ggtgcgggtg      480

cggggcagca ccggcgtggc cgccgccgcc ggcctgcacc ggtatctgcg ggacttctgc      540

ggctgccacg tggcctggag cggcagccag ctgcggctgc cccggcccct gcccgccgtg      600

cccggcgagc tgaccgaggc cacccccaac cggtatcggt actaccagaa cgtgtgcacc      660

cagagctaca gcttcgtgtg gtgggactgg gcccggtggg agcgggagat cgactggatg      720

gccctgaacg gcatcaacct ggccctggcc tggagcggcc aggaggccat ctggcagcgg      780

gtgtacctgg ccctgggcct gacccaggcc gagatcaacg agttcttcac cggccccgcc      840

ttcctggcct ggggccggat gggcaacctg cacacctggg acggccccct gcctccaagc      900

tggcacatca agcagctgta cctgcagcac cgggtgctgg accagatgcg gagcttcggc      960

atgacccccg tgctgcccgc cttcgccggc cacgtgcccg aggccgtgac ccgggtgttc     1020

ccccaagtta acgtgaccaa gatgggcagc tggggccact tcaactgcag ctacagctgc     1080

agcttcctgc tggcccccga ggaccccatc ttccccatca tcggcagcct gttcctgcgg     1140

gagctgatca aggagttcgg caccgaccac atctacggcg ccgacacctt caacgagatg     1200

cagcctccaa gcagcgagcc cagctacctg gccgccgcca ccaccgccgt gtacgaggcc     1260

atgaccgccg tggacaccga ggccgtgtgg ctgctgcagg gctggctgtt ccagcaccag     1320

ccccagttct ggggacctgc ccagatccgg gccgtgctgg gcgccgtgcc tagaggacgg     1380

ctgctggtgc tggacctgtt cgccgagagc cagcccgtgt acacccggac cgccagcttc     1440

cagggccagc ccttcatctg gtgcatgctg cacaacttcg gcggcaacca cggcctgttc     1500

ggcgccctgg aggccgtgaa cggcggcccc gaggccgccc ggctgttccc caacagcacc     1560

atggtgggca ccggcatggc ccccgagggc atcagccaga acgaggtggt gtacagcctg     1620

atggccgagc tgggctggcg gaaggacccc gtgcccgacc tggccgcctg ggtgaccagc     1680

ttcgccgccc ggcggtacgg cgtgagccac cccgacgccg gcgccgcctg gcggctgctg     1740

ctgcggagcg tgtacaactg cagcggcgag gcctgccggg gccacaaccg gagccccctg     1800

gtgcggcggc ccagcctgca gatgaacacc agcatctggt acaaccggag cgacgtgttc     1860

gaggcctggc ggctgctgct gaccagcgcc cccagcctgg ccaccagccc cgccttcaga     1920

tacgacctgc tggacctgac ccggcaggcc gtgcaggagc tggtgagcct gtactacgag     1980

gaggcccgga gcgcctacct gagcaaggag ctggccagcc tgctgcgggc cggcggcgtg     2040

ctggcctacg agctgctgcc cgccctggac gaggtgctgg ccagcgacag ccggttcctg     2100

ctgggcagct ggctggagca ggcccgggcc gccgccgtga gcgaggccga ggccgacttc     2160

tacgagcaga acagccggta tcagctgacc ctgtggggac ctgagggcaa catcctggac     2220

tacgccaaca agcagctggc cggcctggtg gccaactact acaccccaag gtggcggctg     2280

ttcctggagg ccctggtgga cagcgtggcc cagggcatcc ccttccagca gcaccagttc     2340

gacaagaacg tgttccagct ggagcaggcc ttcgtgctga gcaagcagcg gtatcccagc     2400

cagcctagag gagacaccgt ggacctggcc aagaagatct tcctgaagta ctacccccgg     2460

tgggtggccg gcagctgggg acttgaggta ctgttccaag ggcccgagga ccaggtagac     2520

ccacgactca ttgatggaaa atag                                            2544


<210>  249
<211>  2532
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-31-NAGLU-HPC4

<400>  249
atggaggctg tggctgtggc agctgcggtg ggggtccttc tcctggccgg ggccgggggc       60

gcggcaggcg acgctagcag aacactttgt ggcggagagc tggtggacac cctgcagttt      120

gtgtgtggcg acagaggctt cctgttcagc agaggtggag gtggatctag aggaatcctg      180

gaagagtgct gcttcagaga ttgcgatctg gccctgctgg aaacctactg tgccacacca      240

gccagatctg aaggtggagg tggttcaggt ggtggaggtt ccaggccaag ggcggtccct      300

actcaggccg aggcccggga ggccgccgcc gtgcgggccc tggtggcccg gctgctgggc      360

cccggccccg ccgccgactt cagcgttagc gtggagcggg ccctggccgc caagcccggc      420

ctggacacct acagcctggg cggcggcggc gccgcccggg tgcgggtgcg gggcagcacc      480

ggcgtggccg ccgccgccgg cctgcaccgg tatctgcggg acttctgcgg ctgccacgtg      540

gcctggagcg gcagccagct gcggctgccc cggcccctgc ccgccgtgcc cggcgagctg      600

accgaggcca cccccaaccg gtatcggtac taccagaacg tgtgcaccca gagctacagc      660

ttcgtgtggt gggactgggc ccggtgggag cgggagatcg actggatggc cctgaacggc      720

atcaacctgg ccctggcctg gagcggccag gaggccatct ggcagcgggt gtacctggcc      780

ctgggcctga cccaggccga gatcaacgag ttcttcaccg gccccgcctt cctggcctgg      840

ggccggatgg gcaacctgca cacctgggac ggccccctgc ctccaagctg gcacatcaag      900

cagctgtacc tgcagcaccg ggtgctggac cagatgcgga gcttcggcat gacccccgtg      960

ctgcccgcct tcgccggcca cgtgcccgag gccgtgaccc gggtgttccc ccaagttaac     1020

gtgaccaaga tgggcagctg gggccacttc aactgcagct acagctgcag cttcctgctg     1080

gcccccgagg accccatctt ccccatcatc ggcagcctgt tcctgcggga gctgatcaag     1140

gagttcggca ccgaccacat ctacggcgcc gacaccttca acgagatgca gcctccaagc     1200

agcgagccca gctacctggc cgccgccacc accgccgtgt acgaggccat gaccgccgtg     1260

gacaccgagg ccgtgtggct gctgcagggc tggctgttcc agcaccagcc ccagttctgg     1320

ggacctgccc agatccgggc cgtgctgggc gccgtgccta gaggacggct gctggtgctg     1380

gacctgttcg ccgagagcca gcccgtgtac acccggaccg ccagcttcca gggccagccc     1440

ttcatctggt gcatgctgca caacttcggc ggcaaccacg gcctgttcgg cgccctggag     1500

gccgtgaacg gcggccccga ggccgcccgg ctgttcccca acagcaccat ggtgggcacc     1560

ggcatggccc ccgagggcat cagccagaac gaggtggtgt acagcctgat ggccgagctg     1620

ggctggcgga aggaccccgt gcccgacctg gccgcctggg tgaccagctt cgccgcccgg     1680

cggtacggcg tgagccaccc cgacgccggc gccgcctggc ggctgctgct gcggagcgtg     1740

tacaactgca gcggcgaggc ctgccggggc cacaaccgga gccccctggt gcggcggccc     1800

agcctgcaga tgaacaccag catctggtac aaccggagcg acgtgttcga ggcctggcgg     1860

ctgctgctga ccagcgcccc cagcctggcc accagccccg ccttcagata cgacctgctg     1920

gacctgaccc ggcaggccgt gcaggagctg gtgagcctgt actacgagga ggcccggagc     1980

gcctacctga gcaaggagct ggccagcctg ctgcgggccg gcggcgtgct ggcctacgag     2040

ctgctgcccg ccctggacga ggtgctggcc agcgacagcc ggttcctgct gggcagctgg     2100

ctggagcagg cccgggccgc cgccgtgagc gaggccgagg ccgacttcta cgagcagaac     2160

agccggtatc agctgaccct gtggggacct gagggcaaca tcctggacta cgccaacaag     2220

cagctggccg gcctggtggc caactactac accccaaggt ggcggctgtt cctggaggcc     2280

ctggtggaca gcgtggccca gggcatcccc ttccagcagc accagttcga caagaacgtg     2340

ttccagctgg agcaggcctt cgtgctgagc aagcagcggt atcccagcca gcctagagga     2400

gacaccgtgg acctggccaa gaagatcttc ctgaagtact acccccggtg ggtggccggc     2460

agctggggac ttgaggtact gttccaaggg cccgaggacc aggtagaccc acgactcatt     2520

gatggaaaat ag                                                         2532


<210>  250
<211>  2532
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vIGF2-32-NAGLU-HPC4

<400>  250
atggaggctg tggctgtggc agctgcggtg ggggtccttc tcctggccgg ggccgggggc       60

gcggcaggcg acgctagcag aacactttgt ggcggagagc tggtggacac cctgcagttt      120

gtgtgtggcg acagaggctt cctgttcagc agaggtggag gtggatctag aggaatcctg      180

gaagagtgct gcttcagaga atgcgatctg gccctgctgg aaacctactg tgccacacca      240

gccagatctg aaggtggagg tggttcaggt ggtggaggtt ccaggccaag ggcggtccct      300

actcaggccg aggcccggga ggccgccgcc gtgcgggccc tggtggcccg gctgctgggc      360

cccggccccg ccgccgactt cagcgttagc gtggagcggg ccctggccgc caagcccggc      420

ctggacacct acagcctggg cggcggcggc gccgcccggg tgcgggtgcg gggcagcacc      480

ggcgtggccg ccgccgccgg cctgcaccgg tatctgcggg acttctgcgg ctgccacgtg      540

gcctggagcg gcagccagct gcggctgccc cggcccctgc ccgccgtgcc cggcgagctg      600

accgaggcca cccccaaccg gtatcggtac taccagaacg tgtgcaccca gagctacagc      660

ttcgtgtggt gggactgggc ccggtgggag cgggagatcg actggatggc cctgaacggc      720

atcaacctgg ccctggcctg gagcggccag gaggccatct ggcagcgggt gtacctggcc      780

ctgggcctga cccaggccga gatcaacgag ttcttcaccg gccccgcctt cctggcctgg      840

ggccggatgg gcaacctgca cacctgggac ggccccctgc ctccaagctg gcacatcaag      900

cagctgtacc tgcagcaccg ggtgctggac cagatgcgga gcttcggcat gacccccgtg      960

ctgcccgcct tcgccggcca cgtgcccgag gccgtgaccc gggtgttccc ccaagttaac     1020

gtgaccaaga tgggcagctg gggccacttc aactgcagct acagctgcag cttcctgctg     1080

gcccccgagg accccatctt ccccatcatc ggcagcctgt tcctgcggga gctgatcaag     1140

gagttcggca ccgaccacat ctacggcgcc gacaccttca acgagatgca gcctccaagc     1200

agcgagccca gctacctggc cgccgccacc accgccgtgt acgaggccat gaccgccgtg     1260

gacaccgagg ccgtgtggct gctgcagggc tggctgttcc agcaccagcc ccagttctgg     1320

ggacctgccc agatccgggc cgtgctgggc gccgtgccta gaggacggct gctggtgctg     1380

gacctgttcg ccgagagcca gcccgtgtac acccggaccg ccagcttcca gggccagccc     1440

ttcatctggt gcatgctgca caacttcggc ggcaaccacg gcctgttcgg cgccctggag     1500

gccgtgaacg gcggccccga ggccgcccgg ctgttcccca acagcaccat ggtgggcacc     1560

ggcatggccc ccgagggcat cagccagaac gaggtggtgt acagcctgat ggccgagctg     1620

ggctggcgga aggaccccgt gcccgacctg gccgcctggg tgaccagctt cgccgcccgg     1680

cggtacggcg tgagccaccc cgacgccggc gccgcctggc ggctgctgct gcggagcgtg     1740

tacaactgca gcggcgaggc ctgccggggc cacaaccgga gccccctggt gcggcggccc     1800

agcctgcaga tgaacaccag catctggtac aaccggagcg acgtgttcga ggcctggcgg     1860

ctgctgctga ccagcgcccc cagcctggcc accagccccg ccttcagata cgacctgctg     1920

gacctgaccc ggcaggccgt gcaggagctg gtgagcctgt actacgagga ggcccggagc     1980

gcctacctga gcaaggagct ggccagcctg ctgcgggccg gcggcgtgct ggcctacgag     2040

ctgctgcccg ccctggacga ggtgctggcc agcgacagcc ggttcctgct gggcagctgg     2100

ctggagcagg cccgggccgc cgccgtgagc gaggccgagg ccgacttcta cgagcagaac     2160

agccggtatc agctgaccct gtggggacct gagggcaaca tcctggacta cgccaacaag     2220

cagctggccg gcctggtggc caactactac accccaaggt ggcggctgtt cctggaggcc     2280

ctggtggaca gcgtggccca gggcatcccc ttccagcagc accagttcga caagaacgtg     2340

ttccagctgg agcaggcctt cgtgctgagc aagcagcggt atcccagcca gcctagagga     2400

gacaccgtgg acctggccaa gaagatcttc ctgaagtact acccccggtg ggtggccggc     2460

agctggggac ttgaggtact gttccaaggg cccgaggacc aggtagaccc acgactcatt     2520

gatggaaaat ag                                                         2532


