                         SEQUENCE LISTING

<110>  The Regents of the University of California
       City of Hope
 
<120>  Chimeric Antigen Receptors against Human Cytomegalovirus

<130>  034044.209WO1

<150>  US 62/914,408
<151>  2019-10-11

<160>  91    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B2 VH

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Val Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Asp Gly Asn Tyr Thr Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Trp Leu Leu Pro Val Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B2 VL

<400>  2

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Thr Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Ser Asn Arg Trp Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21F6/54E11 VH

<400>  3

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu His Tyr Tyr Gly Ile Asn Pro Leu Leu Gly Cys Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  4
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21F6/54E11 VL

<400>  4

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12E2 VH

<400>  5

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Phe Trp Val Arg Gln Thr Pro Glu Lys Lys Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Arg Leu Lys Ser Asp Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Pro Lys Arg Asp Phe Gln Tyr Leu Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12E2 VL

<400>  6

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Asp Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  7
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13B5 VH

<400>  7

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Phe Asn Pro Ser 
    50                  55                  60                  


Leu Arg Asn Gln Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Glu Ile Thr Ser Val Thr Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Ser Leu Tyr Asp Tyr Asp Glu Gly Tyr Tyr Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120             


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13B5 VL

<400>  8

Glu Ile Val Met Ile Gln Ser Pro Ala Thr Leu Ser Val Asn Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F10 VH

<400>  9

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Ile Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Asn Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Pro Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Arg Thr Gly Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F10 VL

<400>  10

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Val Ser Ile Ser Cys Ser Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  11
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21E9 VH

<400>  11

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Lys Gly Tyr Tyr Gly Ser Ser Gly Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21E9 VL

<400>  12

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-11 VH

<400>  13

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Asn Gly Tyr Ser Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Val 
        115     


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-11 VL


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is V or I

<400>  14

Asp Xaa Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-80 VH

<400>  15

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Ser 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Asp Gly Leu Tyr Ser Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-80 VL

<400>  16

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  17
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A3 VH

<400>  17

Gln Val Gln Leu Gln Gln Pro Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ile Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Gly Thr Gly Ala Tyr Trp Gly Gln Gly Thr Leu Leu Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A3 VL

<400>  18

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  19
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-100 VH

<400>  19

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Asn Gly Tyr Ser Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Val 
        115     


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-100 VL

<400>  20

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Lys Tyr Val Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Formula H1


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is F or Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is S or T

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is L or F

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is S or T

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is D, I, N, S, or T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is F, Y, or S

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is G, Y, or W

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is present or absent and if present Xaa is L or I

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is present or absent and if present Xaa is G

<400>  21

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Formula H2


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is D, N, S, or W

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is D, N, P, T, or W

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is D, G, N, Y, or S

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is D, G, or T

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is D, G, N, or S

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is E, K, S, or Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is present or absent and if present Xaa is P or T

<400>  22

Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Formula H3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is A, S, or V

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is R, N, or S

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is E, G, K, P, R, or S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is G, H, K, L, Y, or W

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is D, L, R, S, or Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is D, F, G, L, S, or Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is A, D, F, G, L, P, or Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is A, D, I, Q, S, V, or Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is present or absent and if present Xaa is E, F, N, S, or Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is present or absent and if present Xaa is A, G, M, L, or P

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is present or absent and if present Xaa is D, L, or Y

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa is present or absent and if present Xaa is A, F, L, or Y

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa is present or absent and if present Xaa is D, F, G, or M

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa is present or absent and if present Xaa is C, D, or Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa is present or absent and if present Xaa is S or Y

<400>  23

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Formula L1


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is E, K, or Q

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is G or S

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is I, L, or V

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is D, G, S, or V

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is D, H, N, S, or T

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is D, N, S, or Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is present or absent and if present Xaa is D, G, or N

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is present or absent and if present Xaa is G, N, or Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is present or absent and if present Xaa is K, N, or S

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa is present or absent and if present Xaa is, F, Y, or T

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa is present or absent and if present Xaa is Y

<400>  24

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  25
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Formula L2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is D, L, R, T, or Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is A, T, or V

<400>  25

Xaa Xaa Ser 
1           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Formula L3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is S, Q, or W

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is H, N, or Q

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is D, G, S, or Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is H, N, R, S, T, or Y

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is E, H, K, R, S, or T

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is D, F, L, S, V, or W

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is L, P, W, or Y

<400>  26

Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F10 VH CDR1

<400>  27

Gly Phe Ser Leu Ser Thr Tyr Gly Ile Gly 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13B5 VH CDR1

<400>  28

Gly Phe Ser Leu Thr Thr Ser Gly Leu Gly 
1               5                   10  


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B2 and 12E2 VH CDR1

<400>  29

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21E9 VH CDR1

<400>  30

Gly Tyr Thr Phe Thr Ile Tyr Gly 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-80 VH CDR1

<400>  31

Gly Tyr Thr Phe Thr Asn Phe Gly 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54E11 VH CDR1

<400>  32

Gly Tyr Thr Phe Thr Ser Tyr Gly 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-11 VH CDR1

<400>  33

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A3 VH CDR1

<400>  34

Gly Tyr Thr Phe Thr Ile Tyr Trp 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-100 VH CDR1

<400>  35

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A3 VH CDR2

<400>  36

Ile Asp Pro Ser Asp Ser Glu Thr 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-11 VH CDR2

<400>  37

Ile Asp Pro Ser Asp Ser Glu Thr 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-100 VH CDR2

<400>  38

Ile Asp Pro Ser Asp Ser Glu Thr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21E9, 54E11, and 2-80 VH CDR2

<400>  39

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B2 VH CDR2

<400>  40

Ile Ser Asp Asp Gly Asn Tyr Thr 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12E2 VH CDR2

<400>  41

Ile Ser Asn Gly Gly Gly Ser Thr 
1               5               


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13B5 VH CDR2

<400>  42

Ile Trp Trp Asp Asp Asp Lys 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F10 VH CDR2

<400>  43

Ile Trp Trp Asn Asp Asn Lys 
1               5           


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54E11 VH CDR3

<400>  44

Ala Arg Glu His Tyr Tyr Gly Ile Asn Pro Leu Leu Gly Cys 
1               5                   10                  


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B2 VH CDR3

<400>  45

Ala Arg Gly Trp Leu Leu Pro Val Phe Ala Tyr 
1               5                   10      


<210>  46
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21E9 VH CDR3

<400>  46

Ala Arg Lys Gly Tyr Tyr Gly Ser Ser Gly Tyr Phe Asp Tyr 
1               5                   10                  


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-80 VH CDR3

<400>  47

Ala Arg Arg Gly Asp Gly Leu Tyr Ser Met Asp Tyr 
1               5                   10          


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F10 VH CDR3

<400>  48

Ala Arg Thr Gly Tyr Phe Asp Val 
1               5               


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-11 and 62-100 VH CDR3

<400>  49

Ser Asn Gly Tyr Ser Ser Phe Ala Tyr 
1               5                   


<210>  50
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12E2 VH CDR3

<400>  50

Val Arg Pro Lys Arg Asp Phe Gln Tyr Leu Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13B5 VH CDR3

<400>  51

Val Arg Ser Leu Tyr Asp Tyr Asp Glu Gly Tyr Tyr Phe Asp Ser 
1               5                   10                  15  


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A3 VH CDR3

<400>  52

Ala Ser Ser Gly Thr Gly Ala Tyr 
1               5               


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-80 VL CDR1

<400>  53

Glu Ser Ile Asp Ser Tyr Gly Asn Ser Phe 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12E2 VL CDR1

<400>  54

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54E11 and 62-11 VL CDR1

<400>  55

Gln Gly Ile Ser Asn Tyr 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B2 VL CDR1

<400>  56

Gln Ser Ile Gly Asn Asn 
1               5       


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13B5 VL CDR1

<400>  57

Gln Ser Ile Ser Asp Tyr 
1               5       


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F10 VL CDR1

<400>  58

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21E9 VL CDR1

<400>  59

Gln Ser Val Ser Asn Asp 
1               5       


<210>  60
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-100 VL CDR1

<400>  60

Gln Ser Ile Ser Asn Asn 
1               5       


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A3 VL CDR1

<400>  61

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  62
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54E11 and 62-11 VL CDR2

<400>  62

Asp Thr Ser 
1           


<210>  63
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12E2 VL CDR2

<400>  63

Leu Ala Ser 
1           


<210>  64
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-80 VL CDR2

<400>  64

Arg Ala Ser 
1           


<210>  65
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F10 VL CDR2

<400>  65

Thr Val Ser 
1           


<210>  66
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21E9, 13B5, and 62-100 VL CDR2

<400>  66

Tyr Ala Ser 
1           


<210>  67
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B2 VL CDR2

<400>  67

Tyr Thr Ser 
1           


<210>  68
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A3 VL CDR2

<400>  68

Leu Val Ser 
1           


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12E2 VL CDR3

<400>  69

Gln His Ser Arg Glu Leu Pro Trp Thr 
1               5                   


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13B5 VL CDR3

<400>  70

Gln Asn Gly His Thr Phe Pro Pro Thr 
1               5                   


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21E9 VL CDR3

<400>  71

Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-80 VL CDR3

<400>  72

Gln Gln Ser Asn Glu Asp Pro Leu Thr 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B2 VL CDR3

<400>  73

Gln Gln Ser Asn Arg Trp Pro Trp Thr 
1               5                   


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  54E11 and 62-11 VL CDR3

<400>  74

Gln Gln Tyr Ser Lys Leu Pro Tyr Thr 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F10 VL CDR3

<400>  75

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-100 VL CDR3

<400>  76

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4A3 VL CDR3

<400>  77

Trp Gln Gly Thr His Phe Pro Tyr Thr 
1               5                   


<210>  78
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader Sequence

<400>  78

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  79
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible Linker

<400>  79

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  80
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 hinge-CH2-CH3 region spacer

<400>  80

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  81
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane region

<400>  81

Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
1               5                   10                  15      


Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  25  


<210>  82
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB co-signaling region

<400>  82

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  83
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta signaling region

<400>  83

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  84
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1B2_CAR

<400>  84

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Val 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Tyr Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Asp Asp Gly Asn Tyr Thr 
65                  70                  75                  80  


Asn Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Asn Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            100                 105                 110         


Thr Ala Met Tyr Tyr Cys Ala Arg Gly Trp Leu Leu Pro Val Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly Asp Ser Val Ser 
                165                 170                 175     


Leu Ser Cys Arg Ala Ser Gln Ser Ile Gly Asn Asn Leu His Trp Tyr 
            180                 185                 190         


Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile Lys Tyr Thr Ser 
        195                 200                 205             


Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Asn Ile Asn Ser Val Glu Thr Glu Asp Phe Gly 
225                 230                 235                 240 


Val Tyr Phe Cys Gln Gln Ser Asn Arg Trp Pro Trp Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
385                 390                 395                 400 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp Ile Tyr Ile 
                485                 490                 495     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            500                 505                 510         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        515                 520                 525             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    530                 535                 540                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
545                 550                 555                 560 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
                565                 570                 575     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            580                 585                 590         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        595                 600                 605             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    610                 615                 620                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
625                 630                 635                 640 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                645                 650                 655     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 670     


<210>  85
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2-80_CAR

<400>  85

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Asn Phe Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Ser Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Thr Ala Thr Tyr Phe Cys Ala Arg Arg Gly Asp Gly Leu Tyr Ser Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
                165                 170                 175     


Thr Ile Ser Cys Arg Ala Ser Glu Ser Ile Asp Ser Tyr Gly Asn Ser 
            180                 185                 190         


Phe Met Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu 
225                 230                 235                 240 


Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro 
                245                 250                 255     


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Ser Lys Tyr 
            260                 265                 270         


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
305                 310                 315                 320 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
                485                 490                 495     


Lys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            500                 505                 510         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        515                 520                 525             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    530                 535                 540                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
545                 550                 555                 560 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                565                 570                 575     


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            580                 585                 590         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        595                 600                 605             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    610                 615                 620                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
625                 630                 635                 640 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                645                 650                 655     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            660                 665                 670         


Leu Pro Pro Arg 
        675     


<210>  86
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12E2_CAR

<400>  86

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Asp Tyr Tyr Met Phe Trp Val Arg Gln Thr Pro Glu 
    50                  55                  60                  


Lys Lys Leu Glu Trp Val Ala Tyr Ile Ser Asn Gly Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Asp Lys Asn Thr Leu Tyr Leu Gln Met Ser Arg Leu Lys Ser Asp Asp 
            100                 105                 110         


Thr Ala Leu Tyr Tyr Cys Val Arg Pro Lys Arg Asp Phe Gln Tyr Leu 
        115                 120                 125             


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
                165                 170                 175     


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            180                 185                 190         


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        195                 200                 205             


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
225                 230                 235                 240 


Pro Val Glu Asp Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                245                 250                 255     


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu 
            260                 265                 270         


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
        275                 280                 285             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    290                 295                 300                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
305                 310                 315                 320 


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
                325                 330                 335     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
            340                 345                 350         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        355                 360                 365             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
    370                 375                 380                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
385                 390                 395                 400 


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
                405                 410                 415     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            420                 425                 430         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        435                 440                 445             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
    450                 455                 460                 


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
465                 470                 475                 480 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                485                 490                 495     


Ser Leu Gly Lys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            500                 505                 510         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
        515                 520                 525             


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
    530                 535                 540                 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
545                 550                 555                 560 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
                565                 570                 575     


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
            580                 585                 590         


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
        595                 600                 605             


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
    610                 615                 620                 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
625                 630                 635                 640 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
                645                 650                 655     


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
            660                 665                 670         


Met Gln Ala Leu Pro Pro Arg 
        675                 


<210>  87
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13B5_CAR

<400>  87

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Ile Leu Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Thr Thr Ser Gly Leu Gly Val Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp 
65                  70                  75                  80  


Lys Tyr Phe Asn Pro Ser Leu Arg Asn Gln Leu Thr Ile Ser Lys Asp 
                85                  90                  95      


Thr Ser Arg Asn Gln Val Phe Leu Glu Ile Thr Ser Val Thr Thr Ala 
            100                 105                 110         


Asp Thr Ala Thr Tyr Tyr Cys Val Arg Ser Leu Tyr Asp Tyr Asp Glu 
        115                 120                 125             


Gly Tyr Tyr Phe Asp Ser Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Ile Val Met Ile Gln Ser Pro Ala Thr Leu Ser Val Asn Pro 
                165                 170                 175     


Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp 
            180                 185                 190         


Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu 
        195                 200                 205             


Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu 
225                 230                 235                 240 


Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Thr Phe Pro 
                245                 250                 255     


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Ser Lys Tyr 
            260                 265                 270         


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
305                 310                 315                 320 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
                485                 490                 495     


Lys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
            500                 505                 510         


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
        515                 520                 525             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    530                 535                 540                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
545                 550                 555                 560 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                565                 570                 575     


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            580                 585                 590         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        595                 600                 605             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    610                 615                 620                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
625                 630                 635                 640 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                645                 650                 655     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            660                 665                 670         


Leu Pro Pro Arg 
        675     


<210>  88
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  18F10_CAR

<400>  88

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Thr Leu Lys Glu Ser Gly Pro Gly 
            20                  25                  30          


Ile Leu Gln Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly 
        35                  40                  45              


Phe Ser Leu Ser Thr Tyr Gly Ile Gly Ile Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Ser Gly Lys Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asn Asp Asn 
65                  70                  75                  80  


Lys Asn Tyr Asn Thr Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp 
                85                  90                  95      


Pro Ser Asn Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala 
            100                 105                 110         


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Thr Gly Tyr Phe Asp Val Trp 
        115                 120                 125             


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Leu Thr Gln 
145                 150                 155                 160 


Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser 
                165                 170                 175     


Cys Ser Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Ile 
            180                 185                 190         


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Thr Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
225                 230                 235                 240 


Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp 
                485                 490                 495     


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            500                 505                 510         


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
        515                 520                 525             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    530                 535                 540                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
545                 550                 555                 560 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
                565                 570                 575     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            580                 585                 590         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        595                 600                 605             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    610                 615                 620                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
625                 630                 635                 640 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                645                 650                 655     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            660                 665                 670         


Pro Arg 
        


<210>  89
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21E9_CAR

<400>  89

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ile Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Thr Ala Thr Tyr Phe Cys Ala Arg Lys Gly Tyr Tyr Gly Ser Ser Gly 
        115                 120                 125             


Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
145                 150                 155                 160 


Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp Val 
            180                 185                 190         


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser 
    210                 215                 220                 


Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala Glu 
225                 230                 235                 240 


Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp 
                485                 490                 495     


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            500                 505                 510         


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
        515                 520                 525             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    530                 535                 540                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
545                 550                 555                 560 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
                565                 570                 575     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            580                 585                 590         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        595                 600                 605             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    610                 615                 620                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
625                 630                 635                 640 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                645                 650                 655     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            660                 665                 670         


Pro Arg 
        


<210>  90
<211>  674
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  21F6_54E11_CAR

<400>  90

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro 
65                  70                  75                  80  


Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
                85                  90                  95      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            100                 105                 110         


Thr Ala Thr Tyr Phe Cys Ala Arg Glu His Tyr Tyr Gly Ile Asn Pro 
        115                 120                 125             


Leu Leu Gly Cys Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
        195                 200                 205             


Asp Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu 
225                 230                 235                 240 


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp 
                485                 490                 495     


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            500                 505                 510         


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
        515                 520                 525             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    530                 535                 540                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
545                 550                 555                 560 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
                565                 570                 575     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            580                 585                 590         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        595                 600                 605             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    610                 615                 620                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
625                 630                 635                 640 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                645                 650                 655     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            660                 665                 670         


Pro Arg 
        


<210>  91
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  62-11_CAR

<400>  91

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Gln Pro Gly Ala Glu 
            20                  25                  30          


Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Ser Glu Thr 
65                  70                  75                  80  


His Tyr Asn Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ser Asn Gly Tyr Ser Ser Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
                165                 170                 175     


Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Asp Thr Ser Ser Leu 
        195                 200                 205             


His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
            260                 265                 270         


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        275                 280                 285             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
305                 310                 315                 320 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                325                 330                 335     


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            340                 345                 350         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        355                 360                 365             


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    370                 375                 380                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
385                 390                 395                 400 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                405                 410                 415     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            420                 425                 430         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        435                 440                 445             


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
    450                 455                 460                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
465                 470                 475                 480 


Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Asp Ile Tyr Ile Trp Ala 
                485                 490                 495     


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
            500                 505                 510         


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
        515                 520                 525             


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
    530                 535                 540                 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
545                 550                 555                 560 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
                565                 570                 575     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            580                 585                 590         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        595                 600                 605             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    610                 615                 620                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
625                 630                 635                 640 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                645                 650                 655     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665                 


