                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Hua, Xianxin
       He, Xin
       Zhang, Xuyao
 
<120>  Compositions and Methods for Targeting CD13 and TIM-3 with CAR T 
       Cells to Treat Acute Myeloid Leukemia

<130>  046483-7259WO1(02410)

<150>  62/913,915
<151>  2019-10-11

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH157

<400>  1

Ala Ala Gln Ala Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
1               5                   10                  15      


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Thr Ala Ser Gly Phe 
            20                  25                  30          


Thr Phe Ser Ser Tyr Ser Met Ala Trp Val Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Gly Pro Glu Trp Val Ser Gly Ile Tyr Pro Ser Asp Gly Lys Thr Arg 
    50                  55                  60                  


Tyr Ala Asp Phe Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Lys Asn Met Leu Tyr Leu Gln Met Asn Asn Leu Glu Pro Glu Asp Thr 
                85                  90                  95      


Ala Leu Tyr Tyr Cys Ala Arg Gly Ile Thr Gly Leu Gly Pro Arg Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        115                 120             


<210>  2
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH157

<400>  2
gcggcccagg tgcagctgca ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg       60

agcctctcct gtacagcctc tggattcacg ttcagtagtt actccatggc ctgggtccgc      120

caggctccag ggaagggacc cgaatgggtc tcagggattt acccttctga tggtaagaca      180

aggtatgcag acttcgtgaa gggccgattc agcatctcca gagacaacgc caagaatatg      240

ttgtatctgc aaatgaacaa cctggaacct gaggacacgg ccctatatta ctgtgcgaga      300

ggtatcaccg gattgggacc ccggggccag gggacccagg tcaccgtctc ctcagcggcc      360

gcc                                                                    363


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH157 CDR1

<400>  3

Ser Tyr Ser Met Ala 
1               5   


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH157 CDR2

<400>  4

Gly Ile Tyr Pro Ser Asp Gly Lys Thr Arg Tyr Ala Asp Phe Val Lys 
1               5                   10                  15      


Gly Arg 
        


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH157 CDR3

<400>  5

Ala Arg Gly Ile Thr Gly Leu Gly Pro 
1               5                   


<210>  6
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3 scFv

<400>  6

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Gly Ala Phe Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
145                 150                 155                 160 


Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp 
    210                 215                 220                 


Ile Ala Ile Tyr Phe Cys Gln Gln Ser Arg Lys Asp Pro Ser Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  7
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3 scFv

<400>  7
caggtgcaac tgcagcagcc tggggctgag ctggtgaagc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacatttacc agttacaata tgcactggat aaagcagaca      120

cctggacagg gcctggaatg gattggagat atttatccag gaaatggtga tacttcctac      180

aatcagaaat tcaaaggcaa ggccacattg actgcagaca aatcctccag cacagtctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagagtgggg      300

ggtgcctttc ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctcaggaggc      360

ggaggatctg gcggcggagg aagtggcgga gggggatcag ggggaggcgg atctgacatt      420

gtgctcaccc aatctccagc ttctttggct gtgtctctag ggcagagagc caccatctcc      480

tgcagagcca gtgaaagtgt tgaatattat ggcacaagtt taatgcagtg gtaccaacag      540

aaaccaggac agccacccaa actcctcatc tatgctgcat ccaacgtaga atctggggtc      600

cctgccaggt ttagtggcag tgggtctggg acagacttca gcctcaacat ccatcctgtg      660

gaggaggatg atattgcaat atatttctgt cagcaaagta ggaaggatcc ttcgacgttc      720

ggtggaggca ccaagctgga gatcaaa                                          747


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3 CDR1

<400>  8

Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3 CDR2

<400>  9

Asp Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3 CDR3

<400>  10

Val Gly Gly Ala Phe Pro Met Asp Tyr 
1               5                   


<210>  11
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PNE scFv

<400>  11

His Ala Ala Arg Pro Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr 
1               5                   10                  15      


Ser Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly 
            20                  25                  30          


Ala Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp 
        35                  40                  45              


His Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly 
    50                  55                  60                  


Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu 
65                  70                  75                  80  


Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val 
                85                  90                  95      


Leu Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr 
            100                 105                 110         


Val Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro 
    130                 135                 140                 


Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser 
145                 150                 155                 160 


Gly Phe Leu Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro 
                165                 170                 175     


Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr 
            180                 185                 190         


Asp Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn 
        195                 200                 205             


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp 
    210                 215                 220                 


Ser Ala Arg Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Thr Leu Thr Val Ser Ser 
                245             


<210>  12
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PNE scFv

<400>  12
catgccgcta gacctgatgc cgtcgtgacc caggaaagcg ccctgacaag cagccctggc       60

gagacagtga ccctgacctg cagatctagc acaggcgccg tgaccaccag caactacgcc      120

agctgggtgc aggaaaagcc cgaccacctg ttcaccggcc tgatcggcgg caccaacaat      180

agagcacctg gcgtgcccgc cagattcagc ggctctctga tcggagataa ggccgccctg      240

accatcactg gcgcccagac agaggacgag gccatctact tttgcgtgct gtggtacagc      300

gaccactggg tgttcggcgg aggcaccaag ctgacagtgc tgggcggagg cggaggatct      360

ggcggcggag gaagtggcgg agggggatca gggggaggcg gatctgatgt gcagctgcag      420

gaatctggcc caggactggt ggcccctagc cagagcctga gcatcacctg taccgtgtcc      480

ggcttcctgc tgaccgacta cggcgtgaac tgggtgcgcc agtctcctgg caagggcctg      540

gaatggctgg gagtgatctg gggcgacgga atcaccgact acaactccgc cctgaagtcc      600

cggctgagcg tgaccaagga caacagcaag agccaggtgt tcctgaagat gaacagcctg      660

cagagcggcg acagcgcccg gtactattgt gtgaccggcc tgttcgacta ctggggccag      720

ggcacaaccc tgaccgtgtc tagc                                             744


<210>  13
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3 CAR

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ala Ala Gln Ala Ala Gln Val Gln Leu 
            20                  25                  30          


Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp 
    50                  55                  60                  


Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Tyr 
65                  70                  75                  80  


Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Val Gly 
        115                 120                 125             


Gly Ala Phe Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
                165                 170                 175     


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            180                 185                 190         


Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln 
        195                 200                 205             


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val 
    210                 215                 220                 


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
225                 230                 235                 240 


Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Ile Tyr 
                245                 250                 255     


Phe Cys Gln Gln Ser Arg Lys Asp Pro Ser Thr Phe Gly Gly Gly Thr 
            260                 265                 270         


Lys Leu Glu Ile Lys His Met Gly Gln Ala Gly Gln Ser Gly Glu Ser 
        275                 280                 285             


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Ser Tyr Ile Trp Ala 
    290                 295                 300                 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
305                 310                 315                 320 


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
                325                 330                 335     


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
            340                 345                 350         


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  14
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3 CAR

<400>  14
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg cggcccaggc ggcccaggtg caactgcagc agcctggggc tgagctggtg      120

aagcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac      180

aatatgcact ggataaagca gacacctgga cagggcctgg aatggattgg agatatttat      240

ccaggaaatg gtgatacttc ctacaatcag aaattcaaag gcaaggccac attgactgca      300

gacaaatcct ccagcacagt ctacatgcag ctcagcagcc tgacatctga ggactctgcg      360

gtctattact gtgcaagagt ggggggtgcc tttcctatgg actactgggg tcaaggaacc      420

tcagtcaccg tctcctcagg aggcggagga tctggcggcg gaggaagtgg cggaggggga      480

tcagggggag gcggatctga cattgtgctc acccaatctc cagcttcttt ggctgtgtct      540

ctagggcaga gagccaccat ctcctgcaga gccagtgaaa gtgttgaata ttatggcaca      600

agtttaatgc agtggtacca acagaaacca ggacagccac ccaaactcct catctatgct      660

gcatccaacg tagaatctgg ggtccctgcc aggtttagtg gcagtgggtc tgggacagac      720

ttcagcctca acatccatcc tgtggaggag gatgatattg caatatattt ctgtcagcaa      780

agtaggaagg atccttcgac gttcggtgga ggcaccaagc tggagatcaa acatatgggc      840

caggccggcc agtccggaga gagcaagtac ggccctccct gccccccttg ccctgctagc      900

tacatctggg cgcccttggc cgggacttgt ggggtccttc tcctgtcact ggttatcacc      960

ctttactgca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1020

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1080

ggaggatgtg aactgagagt gaagttcagc aggagcgcag acgcccccgc gtacaagcag     1140

ggccagaacc agctctataa cgagctcaat ctaggacgaa gagaggagta cgatgttttg     1200

gacaagagac gtggccggga ccctgagatg gggggaaagc cgagaaggaa gaaccctcag     1260

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1320

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1380

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg ctaa           1434


<210>  15
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3 CD13 biCAR

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ala Ala Gln Ala Ala Gln Val Gln Leu 
            20                  25                  30          


Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu 
        35                  40                  45              


Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Ala Trp 
    50                  55                  60                  


Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val Ser Gly Ile Tyr 
65                  70                  75                  80  


Pro Ser Asp Gly Lys Thr Arg Tyr Ala Asp Phe Val Lys Gly Arg Phe 
                85                  90                  95      


Ser Ile Ser Arg Asp Asn Ala Lys Asn Met Leu Tyr Leu Gln Met Asn 
            100                 105                 110         


Asn Leu Glu Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Ile 
        115                 120                 125             


Thr Gly Leu Gly Pro Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ala Ala Thr Ser Gly Gln Thr Val Ser Ser Glu Ser Lys Tyr Gly 
145                 150                 155                 160 


Pro Pro Cys Pro Pro Cys Pro Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                165                 170                 175     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Leu Glu 
    290                 295                 300                 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
305                 310                 315                 320 


Glu Glu Asn Pro Gly Pro Pro Arg Met Ala Leu Pro Val Thr Ala Leu 
                325                 330                 335     


Leu Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Ala 
            340                 345                 350         


Ala Gln Ala Ala Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val 
        355                 360                 365             


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
    370                 375                 380                 


Phe Thr Ser Tyr Asn Met His Trp Ile Lys Gln Thr Pro Gly Gln Gly 
385                 390                 395                 400 


Leu Glu Trp Ile Gly Asp Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr 
                405                 410                 415     


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
            420                 425                 430         


Ser Thr Val Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
        435                 440                 445             


Val Tyr Tyr Cys Ala Arg Val Gly Gly Ala Phe Pro Met Asp Tyr Trp 
    450                 455                 460                 


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                485                 490                 495     


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
            500                 505                 510         


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr 
        515                 520                 525             


Ser Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
    530                 535                 540                 


Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His Pro Val 
                565                 570                 575     


Glu Glu Asp Asp Ile Ala Ile Tyr Phe Cys Gln Gln Ser Arg Lys Asp 
            580                 585                 590         


Pro Ser Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys His Met Gly 
        595                 600                 605             


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
    610                 615                 620                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
625                 630                 635                 640 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
                645                 650                 655     


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
            660                 665                 670         


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
        675                 680                 685             


Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
    690                 695                 700                 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
705                 710                 715                 720 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                725                 730             


<210>  16
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3 CD13 biCAR

<400>  16
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg cggcccaggc ggcccaggtg cagctgcagg agtctggggg aggcttggtg      120

cagcctgggg ggtctctgag cctctcctgt acagcctctg gattcacgtt cagtagttac      180

tccatggcct gggtccgcca ggctccaggg aagggacccg aatgggtctc agggatttac      240

ccttctgatg gtaagacaag gtatgcagac ttcgtgaagg gccgattcag catctccaga      300

gacaacgcca agaatatgtt gtatctgcaa atgaacaacc tggaacctga ggacacggcc      360

ctatattact gtgcgagagg tatcaccgga ttgggacccc ggggccaggg gacccaggtc      420

accgtctcct cagcggccgc cactagtggc cagaccgtgt ctagcgagtc taagtacggc      480

cctccctgcc ctccttgccc atacatctgg gcgcccttgg ccgggacttg tggggtcctt      540

ctcctgtcac tggttatcac cctttactgc agagtgaagt tcagcaggag cgcagacgcc      600

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag      660

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga      720

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc      780

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac      840

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc      900

cctcgcctcg agggaagcgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg      960

gaggagaacc ctggacctcc taggatggcc ttaccagtga ccgccttgct cctgccgctg     1020

gccttgctgc tccacgccgc caggccggga tccgcggccc aggcggccca ggtgcaactg     1080

cagcagcctg gggctgagct ggtgaagcct ggggcctcag tgaagatgtc ctgcaaggct     1140

tctggctaca catttaccag ttacaatatg cactggataa agcagacacc tggacagggc     1200

ctggaatgga ttggagatat ttatccagga aatggtgata cttcctacaa tcagaaattc     1260

aaaggcaagg ccacattgac tgcagacaaa tcctccagca cagtctacat gcagctcagc     1320

agcctgacat ctgaggactc tgcggtctat tactgtgcaa gagtgggggg tgcctttcct     1380

atggactact ggggtcaagg aacctcagtc accgtctcct caggaggcgg aggatctggc     1440

ggcggaggaa gtggcggagg gggatcaggg ggaggcggat ctgacattgt gctcacccaa     1500

tctccagctt ctttggctgt gtctctaggg cagagagcca ccatctcctg cagagccagt     1560

gaaagtgttg aatattatgg cacaagttta atgcagtggt accaacagaa accaggacag     1620

ccacccaaac tcctcatcta tgctgcatcc aacgtagaat ctggggtccc tgccaggttt     1680

agtggcagtg ggtctgggac agacttcagc ctcaacatcc atcctgtgga ggaggatgat     1740

attgcaatat atttctgtca gcaaagtagg aaggatcctt cgacgttcgg tggaggcacc     1800

aagctggaga tcaaacatat ggggaaacac ctttgtccaa gtcccctatt tcccggacct     1860

tctaagccct tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta     1920

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt     1980

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     2040

gccccaccac gcgacttcgc agcctatcgc tccaaacggg gcagaaagaa actcctgtat     2100

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     2160

tgccgatttc cagaagaaga agaaggagga tgtgaactgt aa                        2202


<210>  17
<211>  842
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TIM3 PNE inducible bispecific CAR

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ala Ala Gln Ala Ala Gln Val Gln Leu 
            20                  25                  30          


Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met 
        35                  40                  45              


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met His Trp 
    50                  55                  60                  


Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Tyr 
65                  70                  75                  80  


Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala 
                85                  90                  95      


Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr Met Gln Leu Ser 
            100                 105                 110         


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Val Gly 
        115                 120                 125             


Gly Ala Phe Pro Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
                165                 170                 175     


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            180                 185                 190         


Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gln Trp Tyr Gln Gln 
        195                 200                 205             


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val 
    210                 215                 220                 


Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
225                 230                 235                 240 


Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Ile Ala Ile Tyr 
                245                 250                 255     


Phe Cys Gln Gln Ser Arg Lys Asp Pro Ser Thr Phe Gly Gly Gly Thr 
            260                 265                 270         


Lys Leu Glu Ile Lys His Met Gly Lys His Leu Cys Pro Ser Pro Leu 
        275                 280                 285             


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
    290                 295                 300                 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
305                 310                 315                 320 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
                325                 330                 335     


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            340                 345                 350         


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys 
        355                 360                 365             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    370                 375                 380                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
385                 390                 395                 400 


Gly Gly Cys Glu Leu Leu Glu Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                405                 410                 415     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Pro Arg Met 
            420                 425                 430         


Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu His 
        435                 440                 445             


Ala Ala Arg Pro Asp Ala Val Val Thr Gln Glu Ser Ala Leu Thr Ser 
    450                 455                 460                 


Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 
465                 470                 475                 480 


Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His 
                485                 490                 495     


Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val 
            500                 505                 510         


Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr 
        515                 520                 525             


Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu 
    530                 535                 540                 


Trp Tyr Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
545                 550                 555                 560 


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly 
            580                 585                 590         


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly 
        595                 600                 605             


Phe Leu Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly 
    610                 615                 620                 


Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp 
625                 630                 635                 640 


Tyr Asn Ser Ala Leu Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser 
                645                 650                 655     


Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser 
            660                 665                 670         


Ala Arg Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly 
        675                 680                 685             


Thr Thr Leu Thr Val Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    690                 695                 700                 


Pro Cys Pro Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
705                 710                 715                 720 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg Val Lys Phe Ser Arg 
                725                 730                 735     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            740                 745                 750         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        755                 760                 765             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    770                 775                 780                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
785                 790                 795                 800 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                805                 810                 815     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            820                 825                 830         


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        835                 840         


<210>  18
<211>  2529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TIM3 PNE inducible bispecific CAR

<400>  18
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgggatccg cggcccaggc ggcccaggtg caactgcagc agcctggggc tgagctggtg      120

aagcctgggg cctcagtgaa gatgtcctgc aaggcttctg gctacacatt taccagttac      180

aatatgcact ggataaagca gacacctgga cagggcctgg aatggattgg agatatttat      240

ccaggaaatg gtgatacttc ctacaatcag aaattcaaag gcaaggccac attgactgca      300

gacaaatcct ccagcacagt ctacatgcag ctcagcagcc tgacatctga ggactctgcg      360

gtctattact gtgcaagagt ggggggtgcc tttcctatgg actactgggg tcaaggaacc      420

tcagtcaccg tctcctcagg aggcggagga tctggcggcg gaggaagtgg cggaggggga      480

tcagggggag gcggatctga cattgtgctc acccaatctc cagcttcttt ggctgtgtct      540

ctagggcaga gagccaccat ctcctgcaga gccagtgaaa gtgttgaata ttatggcaca      600

agtttaatgc agtggtacca acagaaacca ggacagccac ccaaactcct catctatgct      660

gcatccaacg tagaatctgg ggtccctgcc aggtttagtg gcagtgggtc tgggacagac      720

ttcagcctca acatccatcc tgtggaggag gatgatattg caatatattt ctgtcagcaa      780

agtaggaagg atccttcgac gttcggtgga ggcaccaagc tggagatcaa acatatgggg      840

aaacaccttt gtccaagtcc cctatttccc ggaccttcta agcccttttg ggtgctggtg      900

gtggttggtg gagtcctggc ttgctatagc ttgctagtaa cagtggcctt tattattttc      960

tgggtgagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgc     1020

cgccccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     1080

tatcgctcca aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1140

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1200

ggaggatgtg aactgctcga gggaagcgga gctactaact tcagcctgct gaagcaggct     1260

ggagacgtgg aggagaaccc tggacctcct aggatggctc tgcctgtgac agctctgctg     1320

ctgcctctgg ccctgctgct gcatgccgct agacctgatg ccgtcgtgac ccaggaaagc     1380

gccctgacaa gcagccctgg cgagacagtg accctgacct gcagatctag cacaggcgcc     1440

gtgaccacca gcaactacgc cagctgggtg caggaaaagc ccgaccacct gttcaccggc     1500

ctgatcggcg gcaccaacaa tagagcacct ggcgtgcccg ccagattcag cggctctctg     1560

atcggagata aggccgccct gaccatcact ggcgcccaga cagaggacga ggccatctac     1620

ttttgcgtgc tgtggtacag cgaccactgg gtgttcggcg gaggcaccaa gctgacagtg     1680

ctgggcggag gcggaggatc tggcggcgga ggaagtggcg gagggggatc agggggaggc     1740

ggatctgatg tgcagctgca ggaatctggc ccaggactgg tggcccctag ccagagcctg     1800

agcatcacct gtaccgtgtc cggcttcctg ctgaccgact acggcgtgaa ctgggtgcgc     1860

cagtctcctg gcaagggcct ggaatggctg ggagtgatct ggggcgacgg aatcaccgac     1920

tacaactccg ccctgaagtc ccggctgagc gtgaccaagg acaacagcaa gagccaggtg     1980

ttcctgaaga tgaacagcct gcagagcggc gacagcgccc ggtactattg tgtgaccggc     2040

ctgttcgact actggggcca gggcacaacc ctgaccgtgt ctagcgagtc taagtacggc     2100

cctccctgcc ctccttgccc atacatctgg gcgcccttgg ccgggacttg tggggtcctt     2160

ctcctgtcac tggttatcac cctttactgc agagtgaagt tcagcaggag cgcagacgcc     2220

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     2280

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     2340

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     2400

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     2460

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     2520

cctcgctaa                                                             2529


<210>  19
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH12

<400>  19
caggtgcagc tgcaggagtc tggaggagga ttggtgcaga ctggggactc tctgagactc       60

tcctgtgtag tctctggagg caccttcaga aactatgtta tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtgtctgct atgaactgga gtggcggcat cacagtctat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cgcggtgtat      240

ctgcaaatgg gcagcctgaa acctggcgac acggccgttt attactgtgc agctgctgca      300

atcgatggtg gaaccgtcag aagcattaac agttatgcct actggggcca ggggacccag      360

gtcaccgtct cctcagcggc cgccactagt                                       390


<210>  20
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH12

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Met Asn Trp Ser Gly Gly Ile Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Gly Ser Leu Lys Pro Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Ile Asp Gly Gly Thr Val Arg Ser Ile Asn Ser Tyr 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        115                 120                 125             


Thr Ser 
    130 


<210>  21
<211>  387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH13

<400>  21
caggtgcagc tgcaggagtc tggaggagga ttggtgcagg ctgggggctc tctgagcctc       60

tcctgtgcag cctctggacg caccttcaag aactatctca tggcctggtt ccgccagact      120

ccagggaagg agcgtgagtt tgtggcagct attactcagc ttggtactag atcattaaat      180

gaagacttcg tgaagggccg attcaccatc tccagggaca acgccaagaa cacggtgtat      240

ctgcaaatga acgacctgaa aactgacgac acgggcgttt attcttgtgc agcaagccta      300

cagagtgggg ggtcactacg gtacgcgaag tatgactatt ggggccaggg gacccaggtc      360

accgtctcct cagcggccgc cactagt                                          387


<210>  22
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH13

<400>  22

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Lys Asn Tyr 
            20                  25                  30          


Leu Met Ala Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Thr Gln Leu Gly Thr Arg Ser Leu Asn Glu Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Thr Asp Asp Thr Gly Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Ser Leu Gln Ser Gly Gly Ser Leu Arg Tyr Ala Lys Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Thr 
        115                 120                 125             


Ser 
    


<210>  23
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH28

<400>  23
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctgaagg caccgtcagc acctacacca tggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagccagg attactggtg ttagtacggc tgtgaagggc      180

cggttcacct tctccagaga cgagcccaaa aacacagtgt atctgcaaat gaacagcctg      240

aaacctgagg acacggccgt ctattactgc gcggcacact atttgggtgg tcgtccagat      300

atgccgactc agtatcaata cttgggccag gggacccagg tcaccgtctc ctcagcggcc      360

gccactagt                                                              369


<210>  24
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH28

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Gly Thr Val Ser Thr Tyr 
            20                  25                  30          


Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Ile Thr Gly Val Ser Thr Ala Val Lys Gly Arg Phe Thr Phe 
    50                  55                  60                  


Ser Arg Asp Glu Pro Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Gly 
                85                  90                  95      


Gly Arg Pro Asp Met Pro Thr Gln Tyr Gln Tyr Leu Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Ala Ala Ala Thr Ser 
        115                 120             


<210>  25
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH30

<400>  25
caggtgcagc tgcaggagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggatt cacgtttggt agttatgtta tgggctggtt ccgccaggct      120

ccagggaagg agcgtgaatt tgtggcaagt attagtacga gtggtggcat aacatcttat      180

gcagactccg tgaagggccg attcactgtc tccagagaca acgccaagaa tacggtctac      240

ttacaaatga acagcctgaa acctgaggac acggccgttt attactgcgc acgagatctg      300

acatactatc gtactggtgg taggttacca gataacgcta atggatatgc gtactggggc      360

cagggtaccc aggtcaccgt ctcctcagcg gccgccacta gt                         402


<210>  26
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH30

<400>  26

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Ser Gly Gly Ile Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Thr Tyr Tyr Arg Thr Gly Gly Arg Leu Pro Asp Asn 
            100                 105                 110         


Ala Asn Gly Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Thr Ser 
    130                 


<210>  27
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH32

<400>  27
caggtgcagc tgcaggagtc tggaggaggc ttggtgcagg ctggggggtc tctaaatctc       60

tcctgtgcag cctctggaag ttccttcaga ctctataccg tcggctggca ccgccaggcg      120

ccagggaagc agcgcgagtt ggtcgcatgg attagtggtg cgggcagcac aaactatcat      180

tcgtccgtga agggccgatt caccatctcc agagacaacg ccaagaacac ggcactcctg      240

caaatgaaca acctggcacc tgaagacacg gccgtctatt actgtaatct actgaactac      300

tggggccagg ggacccaggt caccgtctcc tcagcggccg ccactagt                   348


<210>  28
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH32

<400>  28

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Arg Leu Tyr 
            20                  25                  30          


Thr Val Gly Trp His Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Trp Ile Ser Gly Ala Gly Ser Thr Asn Tyr His Ser Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ala Leu Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Leu Leu Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ala Ala Thr Ser 
        115     


<210>  29
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH33

<400>  29
caggtgcagc tgcaggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag tctctggact cacgccggat gcttatgtca tgggctggtt ccgccaggcc      120

ccagggaagg agcgcgaggg ggtctcatgt attagtccta gtggtggtac tacaagctat      180

ccagactccg tgaagggccg attcaccatc tccagagaca atgccaagaa cacggtgtac      240

ctgcaaatga acagcctgaa acctgaggac acgggcgttt attactgtgc ggcagttgcg      300

ggccgctggt gtgactacgg catgaactac tacggcaaag ggacccaggt caccgtctcc      360

tcagcggccg ccactagt                                                    378


<210>  30
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH33

<400>  30

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Thr Pro Asp Ala Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Pro Ser Gly Gly Thr Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Val Ala Gly Arg Trp Cys Asp Tyr Gly Met Asn Tyr Tyr Gly 
            100                 105                 110         


Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Thr Ser 
        115                 120                 125     


<210>  31
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH38

<400>  31
caggtgcagc tgcaggagtc tgggggaggt ttggtgcagg ctggggactc tctgagactc       60

tcctgtgcag tcggacgcac gttcagtgcg tcaaccttgg gctggttccg ccagtctcca      120

gggaaggagc gtgagtttgt cgcagcgatt agttggtggc gtggtgaggc atactatggg      180

gactccgtga agggccgatt caccatctcc agagacaaca ccaagacaac gatcaatctg      240

caaatgaata gcctgaaacc tgaggacacg gccgtttatt actgtgcacg agcccaattt      300

gatggcgcga cacgggcaga tgactatgac aactggggtc aggggaccca ggtcaccgtc      360

tcctcagcgg ccgccactag t                                                381


<210>  32
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti TIM3 VHH38

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Gly Arg Thr Phe Ser Ala Ser Thr 
            20                  25                  30          


Leu Gly Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg Glu Phe Val Ala 
        35                  40                  45              


Ala Ile Ser Trp Trp Arg Gly Glu Ala Tyr Tyr Gly Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Thr Thr Ile Asn Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Gln Phe Asp Gly Ala Thr Arg Ala Asp Asp Tyr Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Thr Ser 
        115                 120                 125         


<210>  33
<211>  9439
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiCAR2 VHH12

<400>  33
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagctct     5520

agaatggcct taccagtgac cgccttgctc ctgccgctgg ccttgctgct ccacgccgcc     5580

aggccgcagg tgcagctgca ggagtctggg ggaggcttgg tgcagcctgg ggggtctctg     5640

agcctctcct gtacagcctc tggattcacg ttcagtagtt actccatggc ctgggtccgc     5700

caggctccag ggaagggacc cgaatgggtc tcagggattt acccttctga tggtaagaca     5760

aggtatgcag acttcgtgaa gggccgattc agcatctcca gagacaacgc caagaatatg     5820

ttgtatctgc aaatgaacaa cctggaacct gaggacacgg ccctatatta ctgtgcgaga     5880

ggtatcaccg gattgggacc ccggggccag gggacccagg tcaccgtctc ctcagcggcc     5940

gccactagtg agtctaagta cggccctccc tgccctcctt gcccatacat ctgggcgccc     6000

ttggccggga cttgtggggt ccttctcctg tcactggtta tcacccttta ctgcaaacgg     6060

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     6120

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     6180

ctcgagggaa gcggagctac taacttcagc ctgctgaagc aggctggaga cgtggaggag     6240

aaccctggac ctcctaggat ggccttacca gtgaccgcct tgctcctgcc gctggccttg     6300

ctgctccacg ccgccaggcc gggatcccag gtgcagctgc aggagtctgg aggaggattg     6360

gtgcagactg gggactctct gagactctcc tgtgtagtct ctggaggcac cttcagaaac     6420

tatgttatgg gctggttccg ccaggctcca gggaaggagc gtgagtttgt gtctgctatg     6480

aactggagtg gcggcatcac agtctatgca gactccgtga agggccgatt caccatctcc     6540

agagacaacg ccaagaacgc ggtgtatctg caaatgggca gcctgaaacc tggcgacacg     6600

gccgtttatt actgtgcagc tgctgcaatc gatggtggaa ccgtcagaag cattaacagt     6660

tatgcctact ggggccaggg gacccaggtc accgtctcct cagcggccgc cactagttcc     6720

ggaaccacta caccagcgcc cagaccacct accccggctc ctaccatcgc atctcagccc     6780

ttgagtctta gacccgaggc atgtcggcca gcggcggggg gcgcagtgca cacgaggggg     6840

ctggacttcg cctgtgatta catctgggcg cccttggccg ggacttgtgg ggtccttctc     6900

ctgtcactgg ttatcaccct ttactgcaga gtgaagttca gcaggagcgc agacgccccc     6960

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     7020

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     7080

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     7140

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     7200

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     7260

cgctaagtcg acaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt     7320

aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct     7380

attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt     7440

tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac     7500

gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct     7560

ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca     7620

ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaagct gacgtccttt     7680

ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc     7740

ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct     7800

cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg     7860

cctggaattc gagctcggta cctttaagac caatgactta caaggcagct gtagatctta     7920

gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag     7980

atctgctttt tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct     8040

ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag     8100

tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt     8160

cagtgtggaa aatctctagc agtagtagtt catgtcatct tattattcag tatttataac     8220

ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt tattgcagct tataatggtt     8280

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta     8340

gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggctctag ctatcccgcc     8400

cctaactccg cccagttccg cccattctcc gccccatggc tgactaattt tttttattta     8460

tgcagaggcc gaggccgcct cggcctctga gctattccag aagtagtgag gaggcttttt     8520

tggaggccta gctagggacg tacccaattc gccctatagt gagtcgtatt acgcgcgctc     8580

actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg     8640

ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg     8700

cccttcccaa cagttgcgca gcctgaatgg cgaatgggac gcgccctgta gcggcgcatt     8760

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc     8820

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca     8880

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc     8940

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt     9000

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac     9060

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc     9120

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt     9180

aacgcttaca atttaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     9240

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt     9300

caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc     9360

ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa     9420

gatgctgaag atcagttgg                                                  9439


<210>  34
<211>  9442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiCAR2 VHH13

<400>  34
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagctct     5520

agagccagca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     5580

gccgccaggc cgcaggtgca gctgcaggag tctgggggag gcttggtgca gcctgggggg     5640

tctctgagcc tctcctgtac agcctctgga ttcacgttca gtagttactc catggcctgg     5700

gtccgccagg ctccagggaa gggacccgaa tgggtctcag ggatttaccc ttctgatggt     5760

aagacaaggt atgcagactt cgtgaagggc cgattcagca tctccagaga caacgccaag     5820

aatatgttgt atctgcaaat gaacaacctg gaacctgagg acacggccct atattactgt     5880

gcgagaggta tcaccggatt gggaccccgg ggccagggga cccaggtcac cgtctcctca     5940

gcggccgcca ctagtgagtc taagtacggc cctccctgcc ctccttgccc atacatctgg     6000

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     6060

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     6120

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     6180

gaactgctcg agggaagcgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     6240

gaggagaacc ctggacctcc taggatggcc ttaccagtga ccgccttgct cctgccgctg     6300

gccttgctgc tccacgccgc caggccggga tcccaggtgc agctgcagga gtctggagga     6360

ggattggtgc aggctggggg ctctctgagc ctctcctgtg cagcctctgg acgcaccttc     6420

aagaactatc tcatggcctg gttccgccag actccaggga aggagcgtga gtttgtggca     6480

gctattactc agcttggtac tagatcatta aatgaagact tcgtgaaggg ccgattcacc     6540

atctccaggg acaacgccaa gaacacggtg tatctgcaaa tgaacgacct gaaaactgac     6600

gacacgggcg tttattcttg tgcagcaagc ctacagagtg gggggtcact acggtacgcg     6660

aagtatgact attggggcca ggggacccag gtcaccgtct cctcagcggc cgccactagt     6720

tccggaacca ctacaccagc gcccagacca cctaccccgg ctcctaccat cgcatctcag     6780

cccttgagtc ttagacccga ggcatgtcgg ccagcggcgg ggggcgcagt gcacacgagg     6840

gggctggact tcgcctgtga ttacatctgg gcgcccttgg ccgggacttg tggggtcctt     6900

ctcctgtcac tggttatcac cctttactgc agagtgaagt tcagcaggag cgcagacgcc     6960

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     7020

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     7080

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     7140

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     7200

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     7260

cctcgctaag tcgacaatca acctctggat tacaaaattt gtgaaagatt gactggtatt     7320

cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat     7380

gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct     7440

ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct     7500

gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc     7560

gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg     7620

acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa gctgacgtcc     7680

tttccttggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac     7740

gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg     7800

cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg ggccgcctcc     7860

ccgcctggaa ttcgagctcg gtacctttaa gaccaatgac ttacaaggca gctgtagatc     7920

ttagccactt tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac     7980

aagatctgct ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc     8040

tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc     8100

aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt     8160

agtcagtgtg gaaaatctct agcagtagta gttcatgtca tcttattatt cagtatttat     8220

aacttgcaaa gaaatgaata tcagagagtg agaggaactt gtttattgca gcttataatg     8280

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     8340

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctggctc tagctatccc     8400

gcccctaact ccgcccagtt ccgcccattc tccgccccat ggctgactaa ttttttttat     8460

ttatgcagag gccgaggccg cctcggcctc tgagctattc cagaagtagt gaggaggctt     8520

ttttggaggc ctagctaggg acgtacccaa ttcgccctat agtgagtcgt attacgcgcg     8580

ctcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa     8640

tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga     8700

tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc     8760

attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct     8820

agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg     8880

tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga     8940

ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt     9000

ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg     9060

aacaacactc aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc     9120

ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat     9180

attaacgctt acaatttagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt     9240

ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg     9300

cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt     9360

cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta     9420

aaagatgctg aagatcagtt gg                                              9442


<210>  35
<211>  9424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiCAR2 VHH28

<400>  35
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagctct     5520

agagccagca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     5580

gccgccaggc cgcaggtgca gctgcaggag tctgggggag gcttggtgca gcctgggggg     5640

tctctgagcc tctcctgtac agcctctgga ttcacgttca gtagttactc catggcctgg     5700

gtccgccagg ctccagggaa gggacccgaa tgggtctcag ggatttaccc ttctgatggt     5760

aagacaaggt atgcagactt cgtgaagggc cgattcagca tctccagaga caacgccaag     5820

aatatgttgt atctgcaaat gaacaacctg gaacctgagg acacggccct atattactgt     5880

gcgagaggta tcaccggatt gggaccccgg ggccagggga cccaggtcac cgtctcctca     5940

gcggccgcca ctagtgagtc taagtacggc cctccctgcc ctccttgccc atacatctgg     6000

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     6060

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     6120

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     6180

gaactgctcg agggaagcgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     6240

gaggagaacc ctggacctcc taggatggcc ttaccagtga ccgccttgct cctgccgctg     6300

gccttgctgc tccacgccgc caggccggga tcccaggtgc agctgcagga gtctggggga     6360

ggattggtgc aggctggggg ctctctgaga ctctcctgtg cagcctctga aggcaccgtc     6420

agcacctaca ccatggcctg gttccgccag gctccaggga aggagcgtga gtttgtagcc     6480

aggattactg gtgttagtac ggctgtgaag ggccggttca ccttctccag agacgagccc     6540

aaaaacacag tgtatctgca aatgaacagc ctgaaacctg aggacacggc cgtctattac     6600

tgcgcggcac actatttggg tggtcgtcca gatatgccga ctcagtatca atacttgggc     6660

caggggaccc aggtcaccgt ctcctcagcg gccgccacta gttccggaac cactacacca     6720

gcgcccagac cacctacccc ggctcctacc atcgcatctc agcccttgag tcttagaccc     6780

gaggcatgtc ggccagcggc ggggggcgca gtgcacacga gggggctgga cttcgcctgt     6840

gattacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     6900

accctttact gcagagtgaa gttcagcagg agcgcagacg cccccgcgta caagcagggc     6960

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     7020

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     7080

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     7140

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     7200

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgcta agtcgacaat     7260

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     7320

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     7380

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     7440

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     7500

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     7560

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     7620

ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccttg gctgctcgcc     7680

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     7740

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     7800

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcctgg aattcgagct     7860

cggtaccttt aagaccaatg acttacaagg cagctgtaga tcttagccac tttttaaaag     7920

aaaagggggg actggaaggg ctaattcact cccaacgaag acaagatctg ctttttgctt     7980

gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga     8040

acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc     8100

tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct     8160

ctagcagtag tagttcatgt catcttatta ttcagtattt ataacttgca aagaaatgaa     8220

tatcagagag tgagaggaac ttgtttattg cagcttataa tggttacaaa taaagcaata     8280

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     8340

aactcatcaa tgtatcttat catgtctggc tctagctatc ccgcccctaa ctccgcccag     8400

ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag aggccgaggc     8460

cgcctcggcc tctgagctat tccagaagta gtgaggaggc ttttttggag gcctagctag     8520

ggacgtaccc aattcgccct atagtgagtc gtattacgcg cgctcactgg ccgtcgtttt     8580

acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc     8640

ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt     8700

gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     8760

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     8820

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     8880

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     8940

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     9000

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     9060

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     9120

tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc ttacaattta     9180

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     9240

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa     9300

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt     9360

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag     9420

ttgg                                                                  9424


<210>  36
<211>  9457
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiCAR2 VHH30

<400>  36
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagctct     5520

agagccagca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     5580

gccgccaggc cgcaggtgca gctgcaggag tctgggggag gcttggtgca gcctgggggg     5640

tctctgagcc tctcctgtac agcctctgga ttcacgttca gtagttactc catggcctgg     5700

gtccgccagg ctccagggaa gggacccgaa tgggtctcag ggatttaccc ttctgatggt     5760

aagacaaggt atgcagactt cgtgaagggc cgattcagca tctccagaga caacgccaag     5820

aatatgttgt atctgcaaat gaacaacctg gaacctgagg acacggccct atattactgt     5880

gcgagaggta tcaccggatt gggaccccgg ggccagggga cccaggtcac cgtctcctca     5940

gcggccgcca ctagtgagtc taagtacggc cctccctgcc ctccttgccc atacatctgg     6000

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     6060

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     6120

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     6180

gaactgctcg agggaagcgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     6240

gaggagaacc ctggacctcc taggatggcc ttaccagtga ccgccttgct cctgccgctg     6300

gccttgctgc tccacgccgc caggccggga tcccaggtgc agctgcagga gtctggggga     6360

ggattggtgc aggctggggg ctctctgaga ctctcctgtg cagcctctgg attcacgttt     6420

ggtagttatg ttatgggctg gttccgccag gctccaggga aggagcgtga atttgtggca     6480

agtattagta cgagtggtgg cataacatct tatgcagact ccgtgaaggg ccgattcact     6540

gtctccagag acaacgccaa gaatacggtc tacttacaaa tgaacagcct gaaacctgag     6600

gacacggccg tttattactg cgcacgagat ctgacatact atcgtactgg tggtaggtta     6660

ccagataacg ctaatggata tgcgtactgg ggccagggta cccaggtcac cgtctcctca     6720

gcggccgcca ctagttccgg aaccactaca ccagcgccca gaccacctac cccggctcct     6780

accatcgcat ctcagccctt gagtcttaga cccgaggcat gtcggccagc ggcggggggc     6840

gcagtgcaca cgagggggct ggacttcgcc tgtgattaca tctgggcgcc cttggccggg     6900

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcagagt gaagttcagc     6960

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     7020

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     7080

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     7140

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     7200

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     7260

atgcaggccc tgccccctcg ctaagtcgac aatcaacctc tggattacaa aatttgtgaa     7320

agattgactg gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta     7380

atgcctttgt atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa     7440

tcctggttgc tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg     7500

tgcactgtgt ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc     7560

ctttccggga ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc     7620

cttgcccgct gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg     7680

gggaagctga cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg     7740

acgtccttct gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg     7800

ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc     7860

ctttgggccg cctccccgcc tggaattcga gctcggtacc tttaagacca atgacttaca     7920

aggcagctgt agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc     7980

actcccaacg aagacaagat ctgctttttg cttgtactgg gtctctctgg ttagaccaga     8040

tctgagcctg ggagctctct ggctaactag ggaacccact gcttaagcct caataaagct     8100

tgccttgagt gcttcaagta gtgtgtgccc gtctgttgtg tgactctggt aactagagat     8160

ccctcagacc cttttagtca gtgtggaaaa tctctagcag tagtagttca tgtcatctta     8220

ttattcagta tttataactt gcaaagaaat gaatatcaga gagtgagagg aacttgttta     8280

ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca aataaagcat     8340

ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct tatcatgtct     8400

ggctctagct atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg     8460

actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa     8520

gtagtgagga ggcttttttg gaggcctagc tagggacgta cccaattcgc cctatagtga     8580

gtcgtattac gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg     8640

cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga     8700

agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc     8760

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac     8820

acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt     8880

cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc     8940

tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc     9000

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact     9060

cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg     9120

gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc     9180

gaattttaac aaaatattaa cgcttacaat ttaggtggca cttttcgggg aaatgtgcgc     9240

ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct catgagacaa     9300

taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat tcaacatttc     9360

cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc tcacccagaa     9420

acgctggtga aagtaaaaga tgctgaagat cagttgg                              9457


<210>  37
<211>  9403
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiCAR2 VHH32

<400>  37
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagctct     5520

agagccagca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     5580

gccgccaggc cgcaggtgca gctgcaggag tctgggggag gcttggtgca gcctgggggg     5640

tctctgagcc tctcctgtac agcctctgga ttcacgttca gtagttactc catggcctgg     5700

gtccgccagg ctccagggaa gggacccgaa tgggtctcag ggatttaccc ttctgatggt     5760

aagacaaggt atgcagactt cgtgaagggc cgattcagca tctccagaga caacgccaag     5820

aatatgttgt atctgcaaat gaacaacctg gaacctgagg acacggccct atattactgt     5880

gcgagaggta tcaccggatt gggaccccgg ggccagggga cccaggtcac cgtctcctca     5940

gcggccgcca ctagtgagtc taagtacggc cctccctgcc ctccttgccc atacatctgg     6000

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     6060

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     6120

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     6180

gaactgctcg agggaagcgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     6240

gaggagaacc ctggacctcc taggatggcc ttaccagtga ccgccttgct cctgccgctg     6300

gccttgctgc tccacgccgc caggccggga tcccaggtgc agctgcagga gtctggagga     6360

ggcttggtgc aggctggggg gtctctaaat ctctcctgtg cagcctctgg aagttccttc     6420

agactctata ccgtcggctg gcaccgccag gcgccaggga agcagcgcga gttggtcgca     6480

tggattagtg gtgcgggcag cacaaactat cattcgtccg tgaagggccg attcaccatc     6540

tccagagaca acgccaagaa cacggcactc ctgcaaatga acaacctggc acctgaagac     6600

acggccgtct attactgtaa tctactgaac tactggggcc aggggaccca ggtcaccgtc     6660

tcctcagcgg ccgccactag ttccggaacc actacaccag cgcccagacc acctaccccg     6720

gctcctacca tcgcatctca gcccttgagt cttagacccg aggcatgtcg gccagcggcg     6780

gggggcgcag tgcacacgag ggggctggac ttcgcctgtg attacatctg ggcgcccttg     6840

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg cagagtgaag     6900

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     6960

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     7020

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     7080

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     7140

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     7200

cttcacatgc aggccctgcc ccctcgctaa gtcgacaatc aacctctgga ttacaaaatt     7260

tgtgaaagat tgactggtat tcttaactat gttgctcctt ttacgctatg tggatacgct     7320

gctttaatgc ctttgtatca tgctattgct tcccgtatgg ctttcatttt ctcctccttg     7380

tataaatcct ggttgctgtc tctttatgag gagttgtggc ccgttgtcag gcaacgtggc     7440

gtggtgtgca ctgtgtttgc tgacgcaacc cccactggtt ggggcattgc caccacctgt     7500

cagctccttt ccgggacttt cgctttcccc ctccctattg ccacggcgga actcatcgcc     7560

gcctgccttg cccgctgctg gacaggggct cggctgttgg gcactgacaa ttccgtggtg     7620

ttgtcgggga agctgacgtc ctttccttgg ctgctcgcct gtgttgccac ctggattctg     7680

cgcgggacgt ccttctgcta cgtcccttcg gccctcaatc cagcggacct tccttcccgc     7740

ggcctgctgc cggctctgcg gcctcttccg cgtcttcgcc ttcgccctca gacgagtcgg     7800

atctcccttt gggccgcctc cccgcctgga attcgagctc ggtaccttta agaccaatga     7860

cttacaaggc agctgtagat cttagccact ttttaaaaga aaagggggga ctggaagggc     7920

taattcactc ccaacgaaga caagatctgc tttttgcttg tactgggtct ctctggttag     7980

accagatctg agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat     8040

aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact     8100

agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtagt agttcatgtc     8160

atcttattat tcagtattta taacttgcaa agaaatgaat atcagagagt gagaggaact     8220

tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata     8280

aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc     8340

atgtctggct ctagctatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     8400

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     8460

ccagaagtag tgaggaggct tttttggagg cctagctagg gacgtaccca attcgcccta     8520

tagtgagtcg tattacgcgc gctcactggc cgtcgtttta caacgtcgtg actgggaaaa     8580

ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca gctggcgtaa     8640

tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga atggcgaatg     8700

ggacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac     8760

cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc     8820

cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt     8880

tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg     8940

gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag     9000

tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt     9060

ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt     9120

taacgcgaat tttaacaaaa tattaacgct tacaatttag gtggcacttt tcggggaaat     9180

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg     9240

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa     9300

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac     9360

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgg                       9403


<210>  38
<211>  9433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiCAR2 VHH33

<400>  38
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagctct     5520

agagccagca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     5580

gccgccaggc cgcaggtgca gctgcaggag tctgggggag gcttggtgca gcctgggggg     5640

tctctgagcc tctcctgtac agcctctgga ttcacgttca gtagttactc catggcctgg     5700

gtccgccagg ctccagggaa gggacccgaa tgggtctcag ggatttaccc ttctgatggt     5760

aagacaaggt atgcagactt cgtgaagggc cgattcagca tctccagaga caacgccaag     5820

aatatgttgt atctgcaaat gaacaacctg gaacctgagg acacggccct atattactgt     5880

gcgagaggta tcaccggatt gggaccccgg ggccagggga cccaggtcac cgtctcctca     5940

gcggccgcca ctagtgagtc taagtacggc cctccctgcc ctccttgccc atacatctgg     6000

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     6060

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     6120

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     6180

gaactgctcg agggaagcgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     6240

gaggagaacc ctggacctcc taggatggcc ttaccagtga ccgccttgct cctgccgctg     6300

gccttgctgc tccacgccgc caggccggga tcccaggtgc agctgcagga gtctggggga     6360

ggcttggtgc agcctggggg gtctctgaga ctctcctgtg cagtctctgg actcacgccg     6420

gatgcttatg tcatgggctg gttccgccag gccccaggga aggagcgcga gggggtctca     6480

tgtattagtc ctagtggtgg tactacaagc tatccagact ccgtgaaggg ccgattcacc     6540

atctccagag acaatgccaa gaacacggtg tacctgcaaa tgaacagcct gaaacctgag     6600

gacacgggcg tttattactg tgcggcagtt gcgggccgct ggtgtgacta cggcatgaac     6660

tactacggca aagggaccca ggtcaccgtc tcctcagcgg ccgccactag ttccggaacc     6720

actacaccag cgcccagacc acctaccccg gctcctacca tcgcatctca gcccttgagt     6780

cttagacccg aggcatgtcg gccagcggcg gggggcgcag tgcacacgag ggggctggac     6840

ttcgcctgtg attacatctg ggcgcccttg gccgggactt gtggggtcct tctcctgtca     6900

ctggttatca ccctttactg cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     6960

aagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     7020

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     7080

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     7140

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     7200

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctaa     7260

gtcgacaatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat     7320

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct     7380

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag     7440

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc     7500

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc     7560

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct     7620

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga agctgacgtc ctttccttgg     7680

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg     7740

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg     7800

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcctgga     7860

attcgagctc ggtaccttta agaccaatga cttacaaggc agctgtagat cttagccact     7920

ttttaaaaga aaagggggga ctggaagggc taattcactc ccaacgaaga caagatctgc     7980

tttttgcttg tactgggtct ctctggttag accagatctg agcctgggag ctctctggct     8040

aactagggaa cccactgctt aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt     8100

gtgcccgtct gttgtgtgac tctggtaact agagatccct cagacccttt tagtcagtgt     8160

ggaaaatctc tagcagtagt agttcatgtc atcttattat tcagtattta taacttgcaa     8220

agaaatgaat atcagagagt gagaggaact tgtttattgc agcttataat ggttacaaat     8280

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     8340

gtttgtccaa actcatcaat gtatcttatc atgtctggct ctagctatcc cgcccctaac     8400

tccgcccagt tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga     8460

ggccgaggcc gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg     8520

cctagctagg gacgtaccca attcgcccta tagtgagtcg tattacgcgc gctcactggc     8580

cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta atcgccttgc     8640

agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc     8700

ccaacagttg cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg cattaagcgc     8760

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc     8820

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct     8880

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa     8940

acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc     9000

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact     9060

caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg     9120

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat tttaacaaaa tattaacgct     9180

tacaatttag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc     9240

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa     9300

tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt     9360

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct     9420

gaagatcagt tgg                                                        9433


<210>  39
<211>  9436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BiCAR2 VHH38

<400>  39
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagctct     5520

agagccagca tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     5580

gccgccaggc cgcaggtgca gctgcaggag tctgggggag gcttggtgca gcctgggggg     5640

tctctgagcc tctcctgtac agcctctgga ttcacgttca gtagttactc catggcctgg     5700

gtccgccagg ctccagggaa gggacccgaa tgggtctcag ggatttaccc ttctgatggt     5760

aagacaaggt atgcagactt cgtgaagggc cgattcagca tctccagaga caacgccaag     5820

aatatgttgt atctgcaaat gaacaacctg gaacctgagg acacggccct atattactgt     5880

gcgagaggta tcaccggatt gggaccccgg ggccagggga cccaggtcac cgtctcctca     5940

gcggccgcca ctagtgagtc taagtacggc cctccctgcc ctccttgccc atacatctgg     6000

gcgcccttgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc     6060

aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa     6120

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt     6180

gaactgctcg agggaagcgg agctactaac ttcagcctgc tgaagcaggc tggagacgtg     6240

gaggagaacc ctggacctcc taggatggcc ttaccagtga ccgccttgct cctgccgctg     6300

gccttgctgc tccacgccgc caggccggga tcccaggtgc agctgcagga gtctggggga     6360

ggtttggtgc aggctgggga ctctctgaga ctctcctgtg cagtcggacg cacgttcagt     6420

gcgtcaacct tgggctggtt ccgccagtct ccagggaagg agcgtgagtt tgtcgcagcg     6480

attagttggt ggcgtggtga ggcatactat ggggactccg tgaagggccg attcaccatc     6540

tccagagaca acaccaagac aacgatcaat ctgcaaatga atagcctgaa acctgaggac     6600

acggccgttt attactgtgc acgagcccaa tttgatggcg cgacacgggc agatgactat     6660

gacaactggg gtcaggggac ccaggtcacc gtctcctcag cggccgccac tagttccgga     6720

accactacac cagcgcccag accacctacc ccggctccta ccatcgcatc tcagcccttg     6780

agtcttagac ccgaggcatg tcggccagcg gcggggggcg cagtgcacac gagggggctg     6840

gacttcgcct gtgattacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg     6900

tcactggtta tcacccttta ctgcagagtg aagttcagca ggagcgcaga cgcccccgcg     6960

tacaagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     7020

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     7080

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     7140

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     7200

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     7260

taagtcgaca atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac     7320

tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt     7380

gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat     7440

gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca     7500

acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc     7560

cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg     7620

gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaagctgac gtcctttcct     7680

tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct     7740

tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt     7800

ccgcgtcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcct     7860

ggaattcgag ctcggtacct ttaagaccaa tgacttacaa ggcagctgta gatcttagcc     7920

actttttaaa agaaaagggg ggactggaag ggctaattca ctcccaacga agacaagatc     7980

tgctttttgc ttgtactggg tctctctggt tagaccagat ctgagcctgg gagctctctg     8040

gctaactagg gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag     8100

tgtgtgcccg tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag     8160

tgtggaaaat ctctagcagt agtagttcat gtcatcttat tattcagtat ttataacttg     8220

caaagaaatg aatatcagag agtgagagga acttgtttat tgcagcttat aatggttaca     8280

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt     8340

gtggtttgtc caaactcatc aatgtatctt atcatgtctg gctctagcta tcccgcccct     8400

aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt ttatttatgc     8460

agaggccgag gccgcctcgg cctctgagct attccagaag tagtgaggag gcttttttgg     8520

aggcctagct agggacgtac ccaattcgcc ctatagtgag tcgtattacg cgcgctcact     8580

ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct     8640

tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc     8700

ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg ccctgtagcg gcgcattaag     8760

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc     8820

cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc     8880

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa     8940

aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg     9000

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac     9060

actcaaccct atctcggtct attcttttga tttataaggg attttgccga tttcggccta     9120

ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac     9180

gcttacaatt taggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt     9240

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa     9300

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt     9360

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat     9420

gctgaagatc agttgg                                                     9436


