                         SEQUENCE LISTING

<110>  University of Washington
       Jiang, Shaoyi
       Han, Yanjiao
       Luozhong, Sijin
       Zhefan Yuan
 
<120>  MODIFIED ENDONUCLEASES AND RELATED METHODS

<130>  UWOTL-1-72968

<150>  US 62/913916
<151>  2019-10-11

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  1
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggcga c                                               4101


<210>  2
<211>  4335
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  2
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggcga cgagaaggaa aaagagaagg aaaaggaaaa ggagaaagaa     4140

aaggagaaag agaaagagaa ggaaaaggag aaagagaagg agaaggaaaa agaaaaggag     4200

aaggaaaagg agaaggaaaa ggagaaggag aaggaaaagg aaaaagagaa ggagaaggag     4260

aaggagaagg agaaggagaa ggagaaggag aaggagaagg agaaggagaa ggagaaggag     4320

aaggagaagg agaag                                                      4335


<210>  3
<211>  4569
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3
gagaaggaaa aagagaagga aaaggaaaag gagaaagaaa aggagaaaga gaaagagaag       60

gaaaaggaga aagagaagga gaaggaaaaa gaaaaggaga aggaaaagga gaaggaaaag      120

gagaaggaga aggaaaagga aaaagagaag gagaaggaga aggagaagga gaaggagaag      180

gagaaggaga aggagaagga gaaggagaag gagaaggaga aggagaagga gaaggacaag      240

aagtacagca tcggcctgga catcggcacc aactctgtgg gctgggccgt gatcaccgac      300

gagtacaagg tgcccagcaa gaaattcaag gtgctgggca acaccgaccg gcacagcatc      360

aagaagaacc tgatcggagc cctgctgttc gacagcggcg aaacagccga ggccacccgg      420

ctgaagagaa ccgccagaag aagatacacc agacggaaga accggatctg ctatctgcaa      480

gagatcttca gcaacgagat ggccaaggtg gacgacagct tcttccacag actggaagag      540

tccttcctgg tggaagagga taagaagcac gagcggcacc ccatcttcgg caacatcgtg      600

gacgaggtgg cctaccacga gaagtacccc accatctacc acctgagaaa gaaactggtg      660

gacagcaccg acaaggccga cctgcggctg atctatctgg ccctggccca catgatcaag      720

ttccggggcc acttcctgat cgagggcgac ctgaaccccg acaacagcga cgtggacaag      780

ctgttcatcc agctggtgca gacctacaac cagctgttcg aggaaaaccc catcaacgcc      840

agcggcgtgg acgccaaggc catcctgtct gccagactga gcaagagcag acggctggaa      900

aatctgatcg cccagctgcc cggcgagaag aagaatggcc tgttcggaaa cctgattgcc      960

ctgagcctgg gcctgacccc caacttcaag agcaacttcg acctggccga ggatgccaaa     1020

ctgcagctga gcaaggacac ctacgacgac gacctggaca acctgctggc ccagatcggc     1080

gaccagtacg ccgacctgtt tctggccgcc aagaacctgt ccgacgccat cctgctgagc     1140

gacatcctga gagtgaacac cgagatcacc aaggcccccc tgagcgcctc tatgatcaag     1200

agatacgacg agcaccacca ggacctgacc ctgctgaaag ctctcgtgcg gcagcagctg     1260

cctgagaagt acaaagagat tttcttcgac cagagcaaga acggctacgc cggctacatt     1320

gacggcggag ccagccagga agagttctac aagttcatca agcccatcct ggaaaagatg     1380

gacggcaccg aggaactgct cgtgaagctg aacagagagg acctgctgcg gaagcagcgg     1440

accttcgaca acggcagcat cccccaccag atccacctgg gagagctgca cgccattctg     1500

cggcggcagg aagattttta cccattcctg aaggacaacc gggaaaagat cgagaagatc     1560

ctgaccttcc gcatccccta ctacgtgggc cctctggcca ggggaaacag cagattcgcc     1620

tggatgacca gaaagagcga ggaaaccatc accccctgga acttcgagga agtggtggac     1680

aagggcgctt ccgcccagag cttcatcgag cggatgacca acttcgataa gaacctgccc     1740

aacgagaagg tgctgcccaa gcacagcctg ctgtacgagt acttcaccgt gtataacgag     1800

ctgaccaaag tgaaatacgt gaccgaggga atgagaaagc ccgccttcct gagcggcgag     1860

cagaaaaagg ccatcgtgga cctgctgttc aagaccaacc ggaaagtgac cgtgaagcag     1920

ctgaaagagg actacttcaa gaaaatcgag tgcttcgact ccgtggaaat ctccggcgtg     1980

gaagatcggt tcaacgcctc cctgggcaca taccacgatc tgctgaaaat tatcaaggac     2040

aaggacttcc tggacaatga ggaaaacgag gacattctgg aagatatcgt gctgaccctg     2100

acactgtttg aggacagaga gatgatcgag gaacggctga aaacctatgc ccacctgttc     2160

gacgacaaag tgatgaagca gctgaagcgg cggagataca ccggctgggg caggctgagc     2220

cggaagctga tcaacggcat ccgggacaag cagtccggca agacaatcct ggatttcctg     2280

aagtccgacg gcttcgccaa cagaaacttc atgcagctga tccacgacga cagcctgacc     2340

tttaaagagg acatccagaa agcccaggtg tccggccagg gcgatagcct gcacgagcac     2400

attgccaatc tggccggcag ccccgccatt aagaagggca tcctgcagac agtgaaggtg     2460

gtggacgagc tcgtgaaagt gatgggccgg cacaagcccg agaacatcgt gatcgaaatg     2520

gccagagaga accagaccac ccagaaggga cagaagaaca gccgcgagag aatgaagcgg     2580

atcgaagagg gcatcaaaga gctgggcagc cagatcctga aagaacaccc cgtggaaaac     2640

acccagctgc agaacgagaa gctgtacctg tactacctgc agaatgggcg ggatatgtac     2700

gtggaccagg aactggacat caaccggctg tccgactacg atgtggacca tatcgtgcct     2760

cagagctttc tgaaggacga ctccatcgac aacaaggtgc tgaccagaag cgacaagaac     2820

cggggcaaga gcgacaacgt gccctccgaa gaggtcgtga agaagatgaa gaactactgg     2880

cggcagctgc tgaacgccaa gctgattacc cagagaaagt tcgacaatct gaccaaggcc     2940

gagagaggcg gcctgagcga actggataag gccggcttca tcaagagaca gctggtggaa     3000

acccggcaga tcacaaagca cgtggcacag atcctggact cccggatgaa cactaagtac     3060

gacgagaatg acaagctgat ccgggaagtg aaagtgatca ccctgaagtc caagctggtg     3120

tccgatttcc ggaaggattt ccagttttac aaagtgcgcg agatcaacaa ctaccaccac     3180

gcccacgacg cctacctgaa cgccgtcgtg ggaaccgccc tgatcaaaaa gtaccctaag     3240

ctggaaagcg agttcgtgta cggcgactac aaggtgtacg acgtgcggaa gatgatcgcc     3300

aagagcgagc aggaaatcgg caaggctacc gccaagtact tcttctacag caacatcatg     3360

aactttttca agaccgagat taccctggcc aacggcgaga tccggaagcg gcctctgatc     3420

gagacaaacg gcgaaaccgg ggagatcgtg tgggataagg gccgggattt tgccaccgtg     3480

cggaaagtgc tgagcatgcc ccaagtgaat atcgtgaaaa agaccgaggt gcagacaggc     3540

ggcttcagca aagagtctat cctgcccaag aggaacagcg ataagctgat cgccagaaag     3600

aaggactggg accctaagaa gtacggcggc ttcgacagcc ccaccgtggc ctattctgtg     3660

ctggtggtgg ccaaagtgga aaagggcaag tccaagaaac tgaagagtgt gaaagagctg     3720

ctggggatca ccatcatgga aagaagcagc ttcgagaaga atcccatcga ctttctggaa     3780

gccaagggct acaaagaagt gaaaaaggac ctgatcatca agctgcctaa gtactccctg     3840

ttcgagctgg aaaacggccg gaagagaatg ctggcctctg ccggcgaact gcagaaggga     3900

aacgaactgg ccctgccctc caaatatgtg aacttcctgt acctggccag ccactatgag     3960

aagctgaagg gctcccccga ggataatgag cagaaacagc tgtttgtgga acagcacaag     4020

cactacctgg acgagatcat cgagcagatc agcgagttct ccaagagagt gatcctggcc     4080

gacgctaatc tggacaaagt gctgtccgcc tacaacaagc accgggataa gcccatcaga     4140

gagcaggccg agaatatcat ccacctgttt accctgacca atctgggagc ccctgccgcc     4200

ttcaagtact ttgacaccac catcgaccgg aagaggtaca ccagcaccaa agaggtgctg     4260

gacgccaccc tgatccacca gagcatcacc ggcctgtacg agacacggat cgacctgtct     4320

cagctgggag gcgacgagaa ggaaaaagag aaggaaaagg aaaaggagaa agaaaaggag     4380

aaagagaaag agaaggaaaa ggagaaagag aaggagaagg aaaaagaaaa ggagaaggaa     4440

aaggagaagg aaaaggagaa ggagaaggaa aaggaaaaag agaaggagaa ggagaaggag     4500

aaggagaagg agaaggagaa ggagaaggag aaggagaagg agaaggagaa ggagaaggag     4560

aaggagaag                                                             4569


<210>  4
<211>  4803
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  4
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggcga cgagaaggaa aaagagaagg aaaaggaaaa ggagaaagaa     4140

aaggagaaag agaaagagaa ggaaaaggag aaagagaagg agaaggaaaa agaaaaggag     4200

aaggaaaagg agaaggaaaa ggagaaggag aaggaaaagg aaaaagagaa ggagaaggag     4260

aaggagaagg agaaggagaa ggagaaggag aaggagaagg agaaggagaa ggagaaggag     4320

aaggagaagg agaaggagaa ggaaaaagag aaggaaaagg aaaaggagaa agaaaaggag     4380

aaagagaaag agaaggaaaa ggagaaagag aaggagaagg aaaaagaaaa ggagaaggaa     4440

aaggagaagg aaaaggagaa ggagaaggaa aaggaaaaag agaaggagaa ggagaaggag     4500

aaggagaagg agaaggagaa ggagaaggag aaggagaagg agaaggagaa ggagaaggag     4560

aaggagaagg agaaggaaaa agagaaggaa aaggaaaagg agaaagaaaa ggagaaagag     4620

aaagagaagg aaaaggagaa agagaaggag aaggaaaaag aaaaggagaa ggaaaaggag     4680

aaggaaaagg agaaggagaa ggaaaaggaa aaagagaagg agaaggagaa ggagaaggag     4740

aaggagaagg agaaggagaa ggagaaggag aaggagaagg agaaggagaa ggagaaggag     4800

aag                                                                   4803


<210>  5
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  5
gggcacgggc agcttgccgg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  6
gggtgggggg agtttgctcc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  7
ggatggaggg agtttgctcc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  8
gggagggtgg agtttgctcc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9
cgggggaggg agtttgctcc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  10
ggggagggga agtttgctcc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  11
gagtccgagc agaagaagaa                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  12
gaggccgagc agaagaaaga                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  13
gagtcctagc aggagaagaa                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  14
gagtctaagc agaagaagaa                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15
gagttagagc agaagaagaa                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16
gcagatgtag tgtttccaca                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17
acatatgtag tatttccaca                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18
ccagatgtag tattcccaca                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19
ctagatgaag tgcttccaca                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20
ctagatgaag tgcttccaca                                                   20


<210>  21
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21
aagaauggcu ucaagaggcu                                                   20


<210>  22
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22
ucuguaagaa uggcuucaag                                                   20


<210>  23
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  23
ugguucauca ucuguaagaa                                                   20


<210>  24
<211>  20
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  24
acagaugaug aaccagacca                                                   20


