                         SEQUENCE LISTING

<110>  Yale University
 
<120>  Targeted Bifunctional Degraders

<130>  047162-7250WO1 (01242)

<150>  US 62/913,665
<151>  2019-10-10

<150>  US 62/913,668
<151>  2019-10-10

<150>  US 62/913,683
<151>  2019-10-10

<160>  140   

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-acetylated

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = norleucin

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  terminus is C(=O)NH2

<400>  1

Val Lys Phe Asn Lys Pro Phe Val Phe Leu Xaa Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<400>  2

Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr 
1               5                   10                  15      


Lys 
    


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<400>  3

Thr Trp Pro Lys His Phe Asp Lys His Thr Phe Tyr Ser Ile Leu Lys 
1               5                   10                  15      


Leu Gly Lys His 
            20  


<210>  4
<211>  19
<212>  PRT
<213>  Artificial Sequence

<400>  4

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr 
            


<210>  5
<211>  30
<212>  PRT
<213>  Artificial Sequence

<400>  5

Leu Arg Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Leu 
1               5                   10                  15      


Arg Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu 
            20                  25                  30  


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<400>  6

Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg 
1               5                   10                  15      


Lys Arg Leu Leu 
            20  


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  7

Glu Ala Lys Ile Glu Lys His Asn His Tyr Gln Lys 
1               5                   10          


<210>  8
<211>  22
<212>  PRT
<213>  Artificial Sequence

<400>  8

Glu Ala Lys Ile Glu Lys His Asn His Tyr Gln Lys Gln Leu Glu Ile 
1               5                   10                  15      


Ala His Glu Lys Leu Arg 
            20          


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<400>  9

Thr Phe Phe Tyr Gly Gly Ser Arg Gly Lys Arg Asn Asn Phe Lys Thr 
1               5                   10                  15      


Glu Glu Tyr 
            


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  D-amino acid

<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Pen form a ring

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = thiazolidine-4-carboxylic acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Penicillamine

<400>  10

Cys Met Xaa Arg Leu Arg Gly Xaa 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Cys form a ring

<400>  11

Cys Met Pro Arg Leu Arg Gly Cys 
1               5               


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(9)
<223>  Cys and Cys form a ring

<400>  12

His Leu Asp Cys Met Pro Arg Gly Cys Phe Arg Asn 
1               5                   10          


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Cys and Cys form a ring

<400>  13

Cys Gln Val Lys Ser Met Pro Arg Cys 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Cys and Cys form a ring

<400>  14

Cys Thr Thr Pro Met Pro Arg Leu Cys 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Cys and Cys form a ring

<400>  15

Cys Lys Ala Pro Gln Met Pro Arg Cys 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Cys and Cys form a ring

<400>  16

Cys Leu Asn Pro Ser Met Pro Arg Cys 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Cys and Cys form a ring

<400>  17

Cys Leu Val Ser Ser Met Pro Arg Cys 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Cys and Cys form a ring

<400>  18

Cys Leu Gln Pro Met Pro Arg Leu Cys 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Cys and Cys form a ring

<400>  19

Cys Pro Val Ser Ser Met Pro Arg Cys 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Cys and Cys form a ring

<400>  20

Cys Gln Ser Pro Met Pro Arg Leu Cys 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Cys and Cys form a ring

<400>  21

Cys Leu Thr Pro Met Pro Arg Leu Cys 
1               5                   


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  Cys and Cys form a ring

<400>  22

Asp Ser Gly Leu Cys Met Pro Arg Leu Arg Gly Cys Asp Pro Arg 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<400>  23

Thr Pro Ser Ala His Ala Met Ala Leu Gln Ser Leu Ser Val Gly 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-acetylated

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  Cys and Cys form a ring

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  terminus is C(=O)NH2

<400>  24

Asp Ser Gly Leu Cys Met Pro Arg Leu Arg Gly Cys Asp Pro Arg 
1               5                   10                  15  


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Cys form a ring

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-propionylated

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  terminus is C(=O)NH2

<400>  25

Cys Met Pro Arg Leu Arg Gly Cys 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys anc Cys form a ring

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-propionylated D-amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  terminus is C(=O)NH2

<400>  26

Cys Met Pro Arg Leu Arg Gly Cys 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-propionylated D-amino acid

<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Pen form a ring

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = thiazolidine-4-carboxylic acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Penicillamine, terminus is C(=O)NH2

<400>  27

Cys Met Xaa Arg Leu Arg Gly Xaa 
1               5               


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Cys and Cys form a ring

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-acetylated

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  terminus is C(=O)NH2

<400>  28

Cys Met Pro Arg Leu Gly Cys 
1               5           


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Cys form a ring

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-acetylated D-amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  terminus is C(=O)NH2

<400>  29

Cys Met Pro Arg Leu Arg Gly Cys 
1               5               


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-acetylated

<220>
<221>  misc_feature
<222>  (2)..(9)
<223>  Pen and Cys form a ring

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Penicillamine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = thiazolidine-4-carboxylic acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  terminus is C(=O)NH2

<400>  30

Asp Xaa Met Xaa Arg Leu Arg Gly Cys 
1               5                   


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Pen form a ring

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-propionylated D-amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = thiazolidine-4-carboxylic acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Penicillamine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  terminus is C(=O)NH2

<400>  31

Cys Met Xaa Arg Leu Arg Gly Xaa 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Pen form a ring

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-propionylated D-amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = thiazolidine-4-carboxylic acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = sarcosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Penicillamine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  terminus is C(=O)NH2

<400>  32

Cys Met Xaa Arg Leu Arg Xaa Xaa 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Cys form a ring

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-propionylated D-amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = pipecolic acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = sarcosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  terminus is C(=O)NH2

<400>  33

Cys Met Xaa Arg Leu Arg Xaa Cys 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Pen form a ring

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-propionylated D-amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = pipecolic acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Penicillamine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  terminus is C(=O)NH2

<400>  34

Cys Met Xaa Arg Leu Arg Gly Xaa 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  Cys and Pen form a ring

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N-propionylated D-amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = pipecolic acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = sarcosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Penicillamine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  terminus is C(=O)NH2

<400>  35

Cys Met Xaa Arg Leu Arg Xaa Xaa 
1               5               


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  36

Thr Asp Thr Cys Leu Met Leu Pro Leu Leu Leu Gly Cys Asp Glu Glu 
1               5                   10                  15      


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  37

Asp Pro Ile Cys Trp Tyr Phe Pro Arg Leu Leu Gly Cys Thr Thr Leu 
1               5                   10                  15      


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  38

Trp Tyr Pro Cys Tyr Ile Tyr Pro Arg Leu Leu Gly Cys Asp Gly Asp 
1               5                   10                  15      


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  39

Gly Asn Ile Cys Met Leu Ile Pro Gly Leu Leu Gly Cys Ser Tyr Glu 
1               5                   10                  15      


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  40

Val Asn Ser Cys Leu Leu Leu Pro Asn Leu Leu Gly Cys Gly Asp Asp 
1               5                   10                  15      


<210>  41
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  41

Thr Pro Val Cys Ile Leu Leu Pro Ser Leu Leu Gly Cys Asp Thr Gln 
1               5                   10                  15      


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  42

Thr Val Leu Cys Ser Leu Trp Pro Glu Leu Leu Gly Cys Pro Pro Glu 
1               5                   10                  15      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  43

Thr Phe Ser Cys Leu Met Trp Pro Trp Leu Leu Gly Cys Glu Ser Leu 
1               5                   10                  15      


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  44

Phe Gly Thr Cys Tyr Thr Trp Pro Trp Leu Leu Gly Cys Glu Gly Phe 
1               5                   10                  15      


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  45

Ser Leu Phe Cys Arg Leu Leu Leu Thr Pro Val Gly Cys Val Ser Gln 
1               5                   10                  15      


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  46

His Leu Leu Val Leu Pro Arg Gly Leu Leu Gly Cys Thr Thr Leu Ala 
1               5                   10                  15      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  47

Thr Ser Leu Cys Ser Met Phe Pro Asp Leu Leu Gly Cys Phe Asn Leu 
1               5                   10                  15      


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  48

Ser His Pro Cys Gly Arg Leu Pro Met Leu Leu Gly Cys Ala Glu Ser 
1               5                   10                  15      


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<400>  49

Thr Ser Thr Cys Ser Met Val Pro Gly Pro Leu Gly Ala Val Ser Thr 
1               5                   10                  15      


Trp 
    


<210>  50
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  50

Lys Asp Pro Cys Thr Arg Trp Ala Met Leu Leu Gly Cys Asp Gly Glu 
1               5                   10                  15      


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  51

Ile Met Thr Cys Ser Val Tyr Pro Phe Leu Leu Gly Cys Val Asp Lys 
1               5                   10                  15      


<210>  52
<211>  16
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(13)
<223>  Cys and Cys form a ring

<400>  52

Ile His Ser Cys Ala His Val Met Arg Leu Leu Gly Cys Trp Ser Arg 
1               5                   10                  15      


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  53

Cys Gly Gly Gly Pro Phe Trp Trp Trp Pro 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  54

Cys Gly Gly Gly His Lys Tyr Leu Arg Trp 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  55

Cys Gly Gly Gly Lys Arg Ile Phe Met Val 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  56

Cys Gly Gly Gly Lys Trp His Tyr Leu Arg 
1               5                   10  


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  57

Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  58

Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  59

Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro 
1               5                   10          


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<400>  60

Leu Ser Leu Glu Arg Phe Leu Arg Cys Trp Ser Asp Ala Pro Ala 
1               5                   10                  15  


<210>  61
<211>  13
<212>  PRT
<213>  Artificial Sequence

<400>  61

Leu Glu Arg Phe Leu Arg Cys Trp Ser Asp Ala Pro Ala 
1               5                   10              


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<400>  62

Arg Phe Leu Arg Cys Trp Ser Asp Ala Pro Ala 
1               5                   10      


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  63

Leu Arg Cys Trp Ser Asp Ala Pro Ala 
1               5                   


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  64

Cys Trp Ser Asp Ala Pro Ala 
1               5           


<210>  65
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  65

Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Phe Lys Glu 
1               5                   10                  15      


Ala Phe 
        


<210>  66
<211>  13
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  terminus is C(=O)OH or C(=O)NH2

<400>  66

Thr Val Phe Thr Ser Trp Glu Glu Tyr Leu Asp Trp Val 
1               5                   10              


<210>  67
<211>  19
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  terminus is C(=O)OH or C(=O)NH2

<400>  67

Val Glu Pro Asn Cys Asp Ile His Val Met Trp Glu Trp Glu Cys Phe 
1               5                   10                  15      


Glu Arg Leu 
            


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  terminus is C(=O)OH or C(=O)NH2

<400>  68

Lys Arg Phe Lys Gln Asp Gly Gly Cys 
1               5                   


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  terminus is C(=O)OH or C(=O)NH2

<400>  69

Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu 
1               5                   10  


<210>  70
<211>  17
<212>  PRT
<213>  Artificial Sequence

<400>  70

Ser Thr Phe Cys Leu Leu Gly Gln Lys Asp Gln Ser Tyr Cys Phe Thr 
1               5                   10                  15      


Ile 
    


<210>  71
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  71

His Met Arg Cys Leu His Tyr Lys Gly Arg Arg Val Cys Phe Leu Leu 
1               5                   10                  15      


<210>  72
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  72

Lys Thr Met Cys Leu Arg Tyr Asn His Asp Lys Val Cys Phe Arg Ile 
1               5                   10                  15      


<210>  73
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  73

Leu Val Leu Cys Leu Val His Arg Thr Ser Lys His Arg Lys Cys Phe 
1               5                   10                  15      


Val Ile 
        


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  74

His Ala Ile Tyr Pro Arg His 
1               5           


<210>  75
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  75

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  76
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  76

His Met Val Cys Leu Ala Tyr Arg Gly Arg Pro Val Cys Phe Ala Leu 
1               5                   10                  15      


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  77

His Met Val Cys Leu Ser Tyr Arg Gly Arg Pro Val Cys Phe Ser Leu 
1               5                   10                  15      


<210>  78
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  78

His Gln Val Cys Leu Ser Tyr Arg Gly Arg Pro Val Cys Phe Ser Thr 
1               5                   10                  15      


<210>  79
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  79

Arg Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  80
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  80

His Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  81
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  81

Ala Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  82
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  82

Ser Ala Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  83
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  83

Ser Met Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  84
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  84

Ser Asp Arg Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  85
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  85

Ser Asp Ala Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  86
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  86

Ser Asp Val Cys Ala Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  87
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  87

Ser Asp Val Cys Leu Asn Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  88
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  88

Ser Asp Val Cys Leu His Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  89
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  89

Ser Asp Val Cys Leu Ala Tyr Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  90

Ser Asp Val Cys Leu Arg Ala Arg Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  91

Ser Asp Val Cys Leu Arg Tyr Ala Gly Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  92
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  92

Ser Asp Val Cys Leu Arg Tyr Arg Ala Arg Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  93
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  93

Ser Asp Val Cys Leu Arg Tyr Arg Gly Ser Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  94
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  94

Ser Asp Val Cys Leu Arg Tyr Arg Gly Ala Pro Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  95
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  95

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Arg Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  96
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  96

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Ala Val Cys Phe Gln Val 
1               5                   10                  15      


<210>  97
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  97

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Ala Cys Phe Gln Val 
1               5                   10                  15      


<210>  98
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  98

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Arg Gln Val 
1               5                   10                  15      


<210>  99
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  99

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Ala Gln Val 
1               5                   10                  15      


<210>  100
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  100

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Arg Val 
1               5                   10                  15      


<210>  101
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  101

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Leu Val 
1               5                   10                  15      


<210>  102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  102

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Ala Val 
1               5                   10                  15      


<210>  103
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  103

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Trp 
1               5                   10                  15      


<210>  104
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  104

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Leu 
1               5                   10                  15      


<210>  105
<211>  16
<212>  PRT
<213>  Artificial Sequence

<400>  105

Ser Asp Val Cys Leu Arg Tyr Arg Gly Arg Pro Val Cys Phe Gln Ala 
1               5                   10                  15      


<210>  106
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  106

Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr 
1               5                   10                  15      


Ser Asp 
        


<210>  107
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  107

Gly Arg Tyr Gln Ala Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr 
1               5                   10                  15      


Ser Asp 
        


<210>  108
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  108

Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr 
1               5                   10                  15      


Ser Asp 
        


<210>  109
<211>  7
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Cys and Cys bond to a "CLIPS" cross-linker to form a ring (see p.
       81 of the as-filed specification)

<400>  109

Cys His Tyr Arg Phe Arg Cys 
1               5           


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(10)
<223>  Cys and Cys bond to a "CLIPS" cross-linker to form a ring (see p.
       81 of the as-filed specification)

<400>  110

Cys Arg Ile Gly His Tyr Arg Phe Arg Cys 
1               5                   10  


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (4)..(10)
<223>  Cys and Cys bond to a "CLIPS" cross-linker to form a ring (see p.
       81 of the as-filed specification)

<400>  111

Tyr Gln Ala Cys His Tyr Arg Phe Arg Cys 
1               5                   10  


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (6)..(14)
<223>  Cys and Cys bond to a "CLIPS" cross-linker to form a ring (see p.
       81 of the as-filed specification)

<400>  112

Arg Tyr Gln Ala Gln Cys Arg Ile Gly His Tyr Arg Phe Cys 
1               5                   10                  


<210>  113
<211>  18
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (5)..(17)
<223>  Cys and Cys bond to a "CLIPS" cross-linker to form a ring (see p.
       81 of the as-filed specification)

<400>  113

Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr 
1               5                   10                  15      


Cys Asp 
        


<210>  114
<211>  18
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (6)..(16)
<223>  Cys and Cys bond to a "CLIPS" cross-linker to form a ring (see p.
       81 of the as-filed specification)

<400>  114

Gly Arg Tyr Gln Ala Cys Tyr Arg Ile Gly His Tyr Arg Phe Arg Cys 
1               5                   10                  15      


Ser Asp 
        


<210>  115
<211>  18
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (7)..(15)
<223>  Cys and Cys bond to a "CLIPS" cross-linker to form a ring (see p.
       81 of the as-filed specification)

<400>  115

Gly Arg Tyr Gln Ala Gln Cys Arg Ile Gly His Tyr Arg Phe Cys Tyr 
1               5                   10                  15      


Ser Asp 
        


<210>  116
<211>  14
<212>  PRT
<213>  Artificial Sequence

<400>  116

Arg Tyr Gln Ala Gln Cys Arg Ile Gly His Tyr Arg Phe Cys 
1               5                   10                  


<210>  117
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  117

Gly Arg Tyr Gln Cys Gln Tyr Arg Ile Gly His Tyr Arg Phe Arg Tyr 
1               5                   10                  15      


Cys Asp 
        


<210>  118
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  118

Gly Arg Tyr Gln Ala Cys Tyr Arg Ile Gly His Tyr Arg Phe Arg Cys 
1               5                   10                  15      


Ser Asp 
        


<210>  119
<211>  18
<212>  PRT
<213>  Artificial Sequence

<400>  119

Gly Arg Tyr Gln Ala Gln Cys Arg Ile Gly His Tyr Arg Phe Cys Tyr 
1               5                   10                  15      


Ser Asp 
        


<210>  120
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  120

Ser Thr Pro Thr Arg Tyr Ser 
1               5           


<210>  121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  121

Cys Ala Leu Trp His Trp Trp His Cys 
1               5                   


<210>  122
<211>  9
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Thr or Ser

<400>  122

Cys Xaa Trp Leu His Trp Trp Ala Cys 
1               5                   


<210>  123
<211>  8
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = Leu or Met

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Tyr or Phe

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Leu or Met

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = any natural amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Trp, Tyr, or Phe

<400>  123

Xaa His Glu Leu Xaa Xaa Xaa Xaa 
1               5               


<210>  124
<211>  25
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  All amino acids are D-configuration

<400>  124

Asp Asp Asp Glu Lys Gln Leu Lys Glu Arg Trp Tyr Lys Arg Trp Leu 
1               5                   10                  15      


Glu Tyr Leu Asp Glu Phe Lys Lys Asn 
            20                  25  


<210>  125
<211>  25
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  All amino acids are D-configuration

<400>  125

Thr Glu Glu Glu Lys Gln Leu Lys Glu Trp Trp Tyr Lys His Trp Gln 
1               5                   10                  15      


Glu Tyr Leu Glu Glu Phe Lys Lys Asn 
            20                  25  


<210>  126
<211>  20
<212>  PRT
<213>  Artificial Sequence

<400>  126

Gly Ala Cys Pro Pro Cys Leu Trp Gln Val Leu Cys Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Ser Gly 
            20  


<210>  127
<211>  12
<212>  PRT
<213>  Artificial Sequence

<400>  127

His Ile His Asp Asp Leu Leu Arg Tyr Tyr Gly Trp 
1               5                   10          


<210>  128
<211>  27
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  NH2 of Lys is bonded to SEQ ID NO:127

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  C(=O)OH is amidated to C(=O)NH2

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  NH2 of Lys is bonded to SEQ ID NO:127

<400>  128

His Ile His Asp Asp Leu Leu Arg Tyr Tyr Gly Trp Lys Lys Lys Trp 
1               5                   10                  15      


Gly Tyr Tyr Arg Leu Leu Asp Asp His Ile His 
            20                  25          


<210>  129
<211>  7
<212>  PRT
<213>  Artificial Sequence

<400>  129

Lys Arg Trp Ser Arg Tyr Phe 
1               5           


<210>  130
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  130

Tyr Cys Trp Ser Gln Tyr Leu Cys Tyr 
1               5                   


<210>  131
<211>  15
<212>  PRT
<213>  Artificial Sequence

<400>  131

Asp Phe Leu Pro His Tyr Lys Asn Thr Ser Leu Gly His Arg Pro 
1               5                   10                  15  


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<400>  132

Tyr Cys Leu Tyr Gln Ser Trp Cys Tyr 
1               5                   


<210>  133
<211>  13
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (2)..(12)
<223>  Cys and Cys form a ring

<400>  133

Thr Cys Trp Val Leu Glu Gly Leu His Trp Ala Cys Asp 
1               5                   10              


<210>  134
<211>  15
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  misc_feature
<222>  (1)..(15)
<223>  Cys and Cys form a ring

<220>
<221>  misc_feature
<222>  (3)..(13)
<223>  Cys and Cys form a ring

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  terminus is C(=O)NH2

<400>  134

Cys Thr Cys Trp Val Leu Glu Gly Leu His Trp Ala Cys Asp Cys 
1               5                   10                  15  


<210>  135
<211>  13
<212>  PRT
<213>  Artificial Sequence

<400>  135

Thr Val Phe Thr Ser Trp Glu Glu Tyr Leu Asp Trp Val 
1               5                   10              


<210>  136
<211>  19
<212>  PRT
<213>  Artificial Sequence

<400>  136

Val Glu Pro Asn Cys Asp Ile His Val Met Trp Glu Trp Glu Cys Phe 
1               5                   10                  15      


Glu Arg Leu 
            


<210>  137
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  137

Lys Arg Phe Lys Gln Asp Asp Gly Gly Cys 
1               5                   10  


<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<400>  138

Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu 
1               5                   10  


<210>  139
<211>  13
<212>  PRT
<213>  Artificial Sequence

<400>  139

Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr 
1               5                   10              


<210>  140
<211>  15
<212>  PRT
<213>  Artificial Sequence

<400>  140

Cys Asp Cys Ala Trp His Leu Gly Glu Leu Val Trp Cys Thr Cys 
1               5                   10                  15  

