                               SEQUENCE LISTING

<110> ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE 
      UNIVERSITY
 
<120> ONCOLYTIC VIRUSES THAT EXPRESS MULTI-SPECIFIC IMMUNE CELL 
      ENGAGERS

<130> 42206-723.601

<140> PCT/US2020/055073
<141> 2020-10-09

<150> 62/913,655
<151> 2019-10-10

<160> 68    

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 1
tcagcaagga cacatcctct aa                                                22


<210> 2
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
taaggatcct cattggactg c                                                 21


<210> 3
<211> 1602
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgaagagcc agacccaggt gttcatcttc ctgctgctgt gcgtgagcgg cgcccacggc       60

gacatccaga tgacccagag caccagcagc ctgagcgcca gcctgggcga cagggtgacc      120

atcagctgca gcgccagcca gggcatcaac aactacctga actggtacca gcagaagccc      180

gacggcaccg tggagctgct gatctactac accagcaccc tgcagagcgg cgtgcccagc      240

aggttcagcg gcagcggcag cggcaccgac tacagcctga ccatcagcaa cctggagccc      300

gaggacatcg gcacctacta ctgccagcag tacagcaagc tgcccaggac cttcggcggc      360

ggcaccaagc tggagatcaa gggtggcggt ggctccggcg gtggtgggtc gggtggcggc      420

ggatctagcc aggtgcagct gcagcagagc ggcagcgagc tgatgatgcc cggcgccagc      480

gtgaagatca gctgcaaggc caccggctac accttcagca actactggat cgagtgggtg      540

aagcagaggc ccggccacgg cctggagtgg atcggcgaga tcctgcccgg caccggcagg      600

accatctaca acgagaagtt caagggcaag gccaccttca ccgccgacat cagcagcaac      660

accgtgcaga tgcagctgag cagcctgacc agcgaggaca gcgccgtgta ctactgcgcc      720

aggagggact actacggcaa cttctactac gccatggact actggggcca gggcaccagc      780

gtgaccgtga gcagcggtgg cggtggctcc ggcggtggtg ggtcgcaggt tactctgaaa      840

gagtctggcc ctgggatatt gcagccctcc cagaccctca gtctgacttg ttctttctct      900

gggttttcac tgaggacttc tggtatgggt gtaggctgga ttcgtcagcc ttcagggaag      960

ggtctagagt ggctggcaca catttggtgg gatgatgaca agcgctataa tccagccctg     1020

aagagccgac tgacaatctc caaggatacc tccagcaacc aggtattcct caaaatcgcc     1080

agtgtggaca ctgcagatac tgccacatac tactgtgctc aaataaaccc cgcctggttt     1140

gcttactggg gccaagggac tctggtcact gtctctgccg gtggcggtgg ctccggcggt     1200

ggtgggtcgg gtggcggcgg atctgacact gtgctgaccc aatctccagc ttctttggct     1260

gtgtctctag ggcagagggc caccatctcc tgcaaggcca gccaaagtgt tgattttgat     1320

ggtgatagtt ttatgaactg gtaccaacag aaaccaggac agccacccaa actcctcatc     1380

tatactacat ccaatctaga atctgggatc ccagccaggt ttagtgccag tgggtctggg     1440

acagacttca ccctcaacat ccatcctgtg gaggaggagg atactgcaac ctattactgt     1500

cagcaaagta atgaggatcc gtacacgttc ggagggggga ccaagctgga aataaaaggt     1560

aagcctatcc ctaaccctct cctcggtctc gattctacgt aa                        1602


<210> 4
<211> 533
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Lys Ser Gln Thr Gln Val Phe Ile Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      


Gly Ala His Gly Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly 
        35                  40                  45              


Ile Asn Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Glu Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Gly Thr Tyr Tyr Cys Gln Gln Tyr Ser 
            100                 105                 110         


Lys Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln 
    130                 135                 140                 


Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Met Met Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr Trp 
                165                 170                 175     


Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly 
            180                 185                 190         


Glu Ile Leu Pro Gly Thr Gly Arg Thr Ile Tyr Asn Glu Lys Phe Lys 
        195                 200                 205             


Gly Lys Ala Thr Phe Thr Ala Asp Ile Ser Ser Asn Thr Val Gln Met 
    210                 215                 220                 


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Arg Asp Tyr Tyr Gly Asn Phe Tyr Tyr Ala Met Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
        275                 280                 285             


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
    290                 295                 300                 


Arg Thr Ser Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
305                 310                 315                 320 


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr 
                325                 330                 335     


Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser 
            340                 345                 350         


Asn Gln Val Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala 
        355                 360                 365             


Thr Tyr Tyr Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Thr Val Leu Thr Gln Ser Pro 
                405                 410                 415     


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys 
            420                 425                 430         


Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Phe Met Asn Trp Tyr 
        435                 440                 445             


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Thr Thr Ser 
    450                 455                 460                 


Asn Leu Glu Ser Gly Ile Pro Ala Arg Phe Ser Ala Ser Gly Ser Gly 
465                 470                 475                 480 


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Thr Ala 
                485                 490                 495     


Thr Tyr Tyr Cys Gln Gln Ser Asn Glu Asp Pro Tyr Thr Phe Gly Gly 
            500                 505                 510         


Gly Thr Lys Leu Glu Ile Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu 
        515                 520                 525             


Gly Leu Asp Ser Thr 
    530             


<210> 5
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Glu Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln Val Gln Leu Gln 
        115                 120                 125             


Gln Ser Gly Ser Glu Leu Met Met Pro Gly Ala Ser Val Lys Ile Ser 
    130                 135                 140                 


Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr Trp Ile Glu Trp Val 
145                 150                 155                 160 


Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro 
                165                 170                 175     


Gly Thr Gly Arg Thr Ile Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr 
            180                 185                 190         


Phe Thr Ala Asp Ile Ser Ser Asn Thr Val Gln Met Gln Leu Ser Ser 
        195                 200                 205             


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Arg Asp Tyr 
    210                 215                 220                 


Tyr Gly Asn Phe Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
                245                 250                 255     


Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln Thr 
            260                 265                 270         


Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Arg Thr Ser Gly 
        275                 280                 285             


Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu Trp 
    290                 295                 300                 


Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu 
305                 310                 315                 320 


Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val Phe 
                325                 330                 335     


Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr Cys 
            340                 345                 350         


Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        355                 360                 365             


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Asp Thr Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
385                 390                 395                 400 


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser 
                405                 410                 415     


Val Asp Phe Asp Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro 
            420                 425                 430         


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser 
        435                 440                 445             


Gly Ile Pro Ala Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr 
    450                 455                 460                 


Leu Asn Ile His Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys 
465                 470                 475                 480 


Gln Gln Ser Asn Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
                485                 490                 495     


Glu Ile Lys 
            


<210> 6
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Ser Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Met Met Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn 
            20                  25                  30          


Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Leu Pro Gly Thr Gly Arg Thr Ile Tyr Asn Glu Lys 
    50                  55                  60                  


Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Ile Ser Ser Asn Thr Val 
65                  70                  75                  80  


Gln Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Asp Tyr Tyr Gly Asn Phe Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210> 7
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Glu Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 8
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Arg Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Gln Ile Asn Pro Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210> 9
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Asp Thr Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          


Gly Asp Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Thr Thr Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Ala Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Asn Tyr Trp Ile Glu 
1               5   


<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Glu Ile Leu Pro Gly Thr Gly Arg Thr Ile Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Arg Asp Tyr Tyr Gly Asn Phe Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Ser Ala Ser Gln Gly Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Tyr Thr Ser Thr Leu Gln Ser 
1               5           


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gln Gln Tyr Ser Lys Leu Pro Arg Thr 
1               5                   


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Thr Ser Gly Met Gly Val Gly 
1               5           


<210> 17
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Ile Asn Pro Ala Trp Phe Ala Tyr 
1               5               


<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Lys Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Phe Met Asn 
1               5                   10                  15  


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Thr Thr Ser Asn Leu Glu Ser 
1               5           


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210> 22
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Gly Gly Gly Gly Ser 
1               5   


<210> 23
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gly Gly Gly Ser 
1               


<210> 24
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gly Gly 
1       


<210> 25
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210> 26
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210> 27
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Glu Ala Ala Ala Lys 
1               5   


<210> 29
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Glu Ala Ala Ala Arg 
1               5   


<210> 30
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Pro Ala Pro Ala Pro 
1               5   


<210> 31
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210> 32
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Gln Val Gln Leu Leu Glu Ser Gly Ala Glu Leu Ala Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg 
            20                  25                  30          


Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Gly Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 33
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210> 34
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Arg Tyr Thr Met His 
1               5   


<210> 35
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210> 36
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210> 37
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210> 38
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210> 40
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Gln Val Lys Leu Gln Gln Trp Gly Glu Gly Leu Leu Gln Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Arg Thr Cys Val Val Ser Gly Gly Ser Ile Ser Gly Tyr 
            20                  25                  30          


Tyr Tyr Trp Thr Trp Ile Arg Gln Thr Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly His Ile Tyr Gly Asn Gly Ala Thr Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu Asn Leu Asn Ser Val Thr Asp Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Pro Arg Pro Asp Cys Thr Thr Ile Cys Tyr Gly Gly 
            100                 105                 110         


Trp Val Asp Val Trp Gly Pro Gly Asp Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210> 41
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Ala Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ser Arg Asn Glu Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Ala Arg Ala Pro Ile Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Asn Thr Ala Thr Leu Thr Ile Asn Gly Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Arg Ala Ser Asp His 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Arg Val Thr Val Leu 
            100                 105             


<210> 42
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Tyr Met Tyr Trp Phe Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Pro Asn Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Ser Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Ser Tyr Ile Ser His Cys Arg Gly Gly Val Cys Tyr 
            100                 105                 110         


Gly Gly Tyr Phe Glu Phe Trp Gly Gln Gly Ala Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210> 43
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Glu Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Ile Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Lys His Ser 
            20                  25                  30          


Asn Gly Asp Thr Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Ala Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Gly Gln Gly 
                85                  90                  95      


Thr Arg Thr Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 44
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Gly Gly 
            20                  25                  30          


Tyr Gly Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Phe Tyr Ser Ser Ser Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Gln Val Thr Ile Ser Thr Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Asn Ser Met Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Leu Phe Ser Val Val Gly Met Val Tyr Asn Asn 
            100                 105                 110         


Trp Phe Asp Val Trp Gly Pro Gly Val Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210> 45
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Glu Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Thr Gly Ser Thr Ser Asn Ile Gly Gly Tyr 
            20                  25                  30          


Asp Leu His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ile Asn Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ala Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu 
                85                  90                  95      


Asn Ala Gln Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu 
            100                 105                 110 


<210> 46
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Gly Tyr Tyr Tyr Trp Thr 
1               5       


<210> 47
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
His Ile Tyr Gly Asn Gly Ala Thr Thr Asn Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210> 48
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Gly Pro Arg Pro Asp Cys Thr Thr Ile Cys Tyr Gly Gly Trp Val Asp 
1               5                   10                  15      


Val Trp Gly Pro Gly Asp Leu Val Thr Val Ser Ser 
            20                  25              


<210> 49
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Gly Gly Asp Asn Ser Arg Asn Glu Tyr Val His 
1               5                   10      


<210> 50
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Asp Asp Ser Asp Arg Pro Ser 
1               5           


<210> 51
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Gln Val Trp Asp Arg Ala Ser Asp His Pro Val 
1               5                   10      


<210> 52
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Asp His Tyr Met Tyr 
1               5   


<210> 53
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Phe Ile Arg Asn Lys Pro Asn Gly Gly Thr Thr Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 54
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Ser Tyr Ile Ser His Cys Arg Gly Gly Val Cys Tyr Gly Gly Tyr Phe 
1               5                   10                  15      


Glu Phe 
        


<210> 55
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Arg Ser Ser Gln Ser Leu Lys His Ser Asn Gly Asp Thr Phe Leu Ser 
1               5                   10                  15      


<210> 56
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Lys Val Ser Asn Arg Asp Ser 
1               5           


<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Gly Gln Gly Thr Arg Thr Pro Pro Thr 
1               5                   


<210> 58
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Gly Gly Tyr Gly Trp Gly 
1               5       


<210> 59
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Ser Phe Tyr Ser Ser Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210> 60
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Asp Arg Leu Phe Ser Val Val Gly Met Val Tyr Asn Asn Trp Phe Asp 
1               5                   10                  15      


Val 
    


<210> 61
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Thr Gly Ser Thr Ser Asn Ile Gly Gly Tyr Asp Leu His 
1               5                   10              


<210> 62
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Asp Ile Asn Lys Arg Pro Ser 
1               5           


<210> 63
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Gln Ser Tyr Asp Ser Ser Leu Asn Ala Gln Val 
1               5                   10      


<210> 64
<211> 69
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 64
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210> 65
<211> 54
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Pro Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro 
1               5                   10                  15      


Ala Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe 
            20                  25                  30          


Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr 
        35                  40                  45              


Leu Arg Phe Ser Val Val 
    50                  


<210> 66
<211> 54
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 66
Pro Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro 
1               5                   10                  15      


Ala Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe 
            20                  25                  30          


Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr 
        35                  40                  45              


Leu Arg Phe Ser Val Val 
    50                  


<210> 67
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 68
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


