                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Incorporated
 
<120>  RAN PROTEINS AS BIOMARKERS IN CAG/CTG EXPANSION DISORDERS

<130>  U1202.70072WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/913,662
<151>  2019-10-10

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala 
            20  


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu 
        


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys 
1               5                   10                  15      


Cys Cys Cys Cys 
            20  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(1)
<223>  May repeat 5, 10, 15, 20, 25, 30, 35, 40, or more than 40 times

<400>  5

Ala Ala Pro Ala Ala Ala Pro Ala Ala Thr Arg Pro Gly Cys Gly 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(1)
<223>  May repeat 5, 10, 15, 20, 25, 30, 35, 40, or more than 40 times

<400>  6

Ser Arg Pro Arg Arg His Pro Ala Arg Leu Trp Leu Arg Ser Arg 
1               5                   10                  15  


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (1)..(1)
<223>  May repeat 5, 10, 15, 20, 25, 30, 35, 40, or more than 40 times

<400>  7

Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln 
1               5                   10                  15      


Pro Pro Pro 
            


<210>  8
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (2)..(2)
<223>  May repeat 5, 10, 15, 20, 25, 30, 35, 40, or more than 40 times

<400>  8

Met Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro 
1               5                   10                  15      


Gln Pro Pro Pro 
            20  


<210>  9
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  repeat_region
<222>  (1)..(3)
<223>  May repeat 5, 10, 15, 20, 25, 30, 35, 40, or more than 40 times

<400>  9
cag                                                                      3


<210>  10
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  repeat_region
<222>  (1)..(3)
<223>  May repeat 5, 10, 15, 20, 25, 30, 35, 40, or more than 40 times

<400>  10
cwg                                                                      3


<210>  11
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Ala Arg Arg Arg Asp Thr Arg Leu Ser Ser Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Ser Ile Ser Ile Ser Ser Ser Ser Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Ser Ser Ser Ser Thr Ser Ala Gly Leu Arg Gly Ser Ser Pro 
        35                  40                  45              


Arg Gly Pro Pro His Gln Pro Ser Arg Thr Ser Thr Ser Thr Phe Pro 
    50                  55                  60                  


Val Leu Arg Arg Thr Pro Ala Ala Pro Pro Leu Leu Arg Pro Ser Pro 
65                  70                  75                  80  


Ser Thr Ser Thr Pro Thr Arg Arg 
                85              


<210>  12
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Ser Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn 
1               5                   10                  15      


Ser Ser Ser Ser Ser Ser Ser Ser Ser Arg Arg Pro Arg Leu Pro Met 
            20                  25                  30          


Ser Ala Ser Pro Ala Ala Ala Ala Phe 
        35                  40      


<210>  13
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  REPEAT
<222>  (2)..(2)
<223>  May repeat 5, 10, 15, 20, 25, 30, 35, 40, or more than 40 times

<400>  13

Ser Ser Asn Ser Ser Ser Ser Ser Ser Ser Arg Gly Thr Tyr Gln Asp 
1               5                   10                  15      


Arg Val His Ile His Val Lys Gly Gln Pro Pro Val Gln Glu His Leu 
            20                  25                  30          


Gly Val Ile 
        35  


<210>  14
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ser Val Arg Pro Ala Ala Arg Gly Pro Arg Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Ser Ser Arg Arg Trp Pro Gly Arg Ala Gly Arg Pro 
            20                  25                  30          


Pro Ala Ala Leu Gly Gly Thr Gln Ala Pro Arg Pro Ser Leu Trp Pro 
        35                  40                  45              


Glu Ile Gly Arg Pro Arg Gly Ala Thr Ala Ala Ala Ala Arg Pro Gly 
    50                  55                  60                  


Trp Arg Gly Gly Ser Gln Ala Arg Pro Gly Ala Ser Pro Pro Gly Pro 
65                  70                  75                  80  


Val Asp Thr Ala Gly Pro Gly Gly Arg His Leu Ala Arg Thr Cys Pro 
                85                  90                  95      


Arg Gly Pro Arg Val Pro Gly Thr Met Ala Thr Thr Gly Ala Pro Thr 
            100                 105                 110         


Thr Thr Arg Pro Met Ala Arg Ala Ala Gly Ala Ala Arg Arg Pro Trp 
        115                 120                 125             


Pro Gly Pro Thr Thr Arg His Pro Pro Tyr Asp Thr Arg Pro Arg Ala 
    130                 135                 140                 


Pro Pro Gly Ala Arg Pro Gly Leu Pro Gly Pro Arg Ala Arg Pro Ala 
145                 150                 155                 160 


Pro Arg Leu Leu Gly Thr Ala Gly Asp Ser Pro Thr Ala Thr Thr Arg 
                165                 170                 175     


Arg Thr Asp Trp Pro Gly Pro Ala Gly Arg Ala Pro Gly Arg Ala Cys 
            180                 185                 190         


Thr Asn Pro Thr Ala Arg Val Thr Met Ile Gly Ala 
        195                 200                 


<210>  15
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Ala Gly Gly Cys Cys Gly Gly Cys Gly Gly Cys Thr Cys Gly Gly Gly 
1               5                   10                  15      


Gly Cys Cys Cys Cys Cys Gly Cys Ala Gly Cys Ala Gly Cys Ala Gly 
            20                  25                  30          


Cys Ala Gly Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Cys Cys Ala 
        35                  40                  45              


Gly Gly Cys Cys Gly Gly Gly Cys Cys Gly Gly Gly Cys Gly Gly Cys 
    50                  55                  60                  


Cys Ala Cys Cys Ala Gly Cys Gly Gly Cys Cys Cys Thr Cys Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Thr Ala Cys Cys Cys Ala Gly Gly Cys Cys Cys Cys Ala 
                85                  90                  95      


Cys Gly Gly Cys Cys Gly Ala Gly Cys Cys Thr Cys Thr Gly Gly Cys 
            100                 105                 110         


Cys Gly Gly Ala Gly Ala Thr Cys Gly Gly Cys Cys Gly Cys Cys Cys 
        115                 120                 125             


Ala Cys Gly Gly Gly Gly Gly Gly Cys Cys Ala Cys Ala Gly Cys Ala 
    130                 135                 140                 


Gly Cys Gly Gly Cys Cys Gly Cys Thr Cys Gly Cys Cys Cys Ala Gly 
145                 150                 155                 160 


Gly Ala Thr Gly Gly Ala Gly Ala Gly Gly Cys Gly Gly Gly Thr Cys 
                165                 170                 175     


Cys Cys Ala Gly Gly Cys Cys Cys Gly Gly Cys Cys Cys Gly Gly Ala 
            180                 185                 190         


Gly Cys Gly Ala Gly Thr Cys Cys Cys Cys Cys Ala Gly Gly Gly Cys 
        195                 200                 205             


Cys Thr Gly Thr Cys Gly Ala Cys Ala Cys Gly Gly Cys Gly Gly Gly 
    210                 215                 220                 


Gly Cys Cys Cys Gly Gly Thr Gly Gly Cys Cys Gly Gly Cys Ala Thr 
225                 230                 235                 240 


Cys Thr Gly Gly Cys Cys Cys Gly Cys Ala Cys Gly Thr Gly Thr Cys 
                245                 250                 255     


Cys Gly Ala Gly Gly Gly Gly Cys Cys Cys Cys Cys Gly Gly Gly Thr 
            260                 265                 270         


Cys Cys Cys Cys Gly Gly Cys Ala Cys Cys Ala Thr Gly Gly Cys Thr 
        275                 280                 285             


Ala Cys Thr Ala Cys Cys Gly Gly Gly Gly Cys Thr Cys Cys Gly Ala 
    290                 295                 300                 


Cys Thr Ala Cys Gly Ala Cys Gly Ala Gly Gly Cys Cys Gly Ala Thr 
305                 310                 315                 320 


Gly Gly Cys Cys Cys Gly Gly Gly Cys Ala Gly Cys Gly Gly Gly Gly 
                325                 330                 335     


Gly Cys Gly Gly Cys Gly Ala Gly Gly Ala Gly Gly Cys Cys Ala Thr 
            340                 345                 350         


Gly Gly Cys Cys Gly Gly Gly Gly Cys Cys Thr Ala Cys Gly Ala Cys 
        355                 360                 365             


Gly Cys Gly Cys Cys Ala Cys Cys Cys Cys Cys Cys Gly Thr Ala Cys 
    370                 375                 380                 


Gly Ala Cys Ala Cys Gly Cys Gly Thr Cys Cys Thr Cys Gly Gly Gly 
385                 390                 395                 400 


Cys Gly Cys Cys Ala Cys Cys Gly Gly Gly Cys Gly Cys Thr Cys Gly 
                405                 410                 415     


Cys Cys Cys Ala Gly Gly Ala Cys Thr Cys Cys Cys Cys Gly Gly Gly 
            420                 425                 430         


Cys Cys Thr Cys Gly Gly Gly Cys Cys Cys Gly Gly Cys Cys Thr Gly 
        435                 440                 445             


Cys Gly Cys Cys Thr Cys Gly Cys Cys Thr Thr Cys Thr Cys Gly Gly 
    450                 455                 460                 


Cys Ala Cys Gly Gly Cys Cys Gly Gly Cys Gly Ala Cys Thr Cys Cys 
465                 470                 475                 480 


Cys Cys Ala Ala Cys Gly Gly Cys Thr Ala Cys Thr Ala Cys Cys Cys 
                485                 490                 495     


Gly Gly Cys Gly Cys Ala Cys Gly Gly Ala Cys Thr Gly Gly Cys Cys 
            500                 505                 510         


Ala Gly Gly Cys Cys Cys Cys Gly Cys Gly Gly Gly Cys Cys Gly Gly 
        515                 520                 525             


Gly Cys Thr Cys Cys Ala Gly Gly Ala Ala Gly Gly Gly Cys Cys Thr 
    530                 535                 540                 


Gly Cys Ala Cys Gly Ala Ala Cys Cys Cys Thr Ala Cys Ala Gly Cys 
545                 550                 555                 560 


Gly Ala Gly Ala Gly Thr Gly Ala Cys Gly Ala Thr Gly Ala Thr Thr 
                565                 570                 575     


Gly Gly Thr Gly Cys Ala Gly Gly Ala Thr Cys Cys Cys Thr Cys Gly 
            580                 585                 590         


Ala Gly Gly Ala Cys Thr Ala Cys Ala Ala Ala Gly Ala Cys Cys Ala 
        595                 600                 605             


Cys Gly Ala Cys Gly Gly Ala Gly Ala Thr Thr Ala Cys Ala Ala Ala 
    610                 615                 620                 


Gly Ala Thr Cys Ala Cys Gly Ala Cys Ala Thr Cys Gly Ala Thr Thr 
625                 630                 635                 640 


Ala Cys Ala Ala Gly Gly Ala Cys Gly Ala Cys Gly Ala Cys Gly Ala 
                645                 650                 655     


Cys Ala Ala Gly Thr Ala Ala 
            660             


<210>  16
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Arg Gln Leu Pro Gly Phe 
1               5                   10                  15      


Arg Pro Arg Leu Cys Pro Glu Cys Gly Gly Ile Ser Val Arg Val Gly 
            20                  25                  30          


Leu Gly Pro Val Ala Val Leu Gln Pro Val Ala Pro Gly Pro Phe Val 
        35                  40                  45              


Phe Gly Pro Val Ala Arg Ala Leu Pro His Pro Val Ala Pro Leu Glu 
    50                  55                  60                  


Ser Val Arg Pro Leu Ala Leu Val His Pro Leu Pro Leu Ala Leu Gln 
65                  70                  75                  80  


Ala Asp Ala Val Ala Leu Ala Leu Arg Pro Gly Ala Leu Val Arg Val 
                85                  90                  95      


Ala Ala Gly Pro Gly Val Asp Ala Gln His Leu Glu Ala Val Ala Pro 
            100                 105                 110         


Arg Ala Gly Val Phe Ala Leu Ala Leu Gly Ala Gly Ala Asp Ala Met 
        115                 120                 125             


Ala Val 
    130 


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Arg Gly Ser Ser Pro Arg Gly Pro Pro His Gln Pro Ser Arg Thr 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Val Ser Arg Arg Leu Ala Gln Thr Ala His Val Gly Gln Gln Ser 
1               5                   10                  15  


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Arg Arg Pro Arg Leu Pro Met Ser Ala Ser Pro Ala Ala Ala Ala Phe 
1               5                   10                  15      


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gly Leu Gln Arg His Gly Glu Gly Pro Ile His Arg Leu Ala Arg 
1               5                   10                  15  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Gly Thr Tyr Gln Asp Arg Val His Ile His Val Lys Gly Gln 
1               5                   10                  


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Phe Phe Lys Val Gly Phe Ser Ser Leu Pro Lys Leu Phe 
1               5                   10              


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Thr Gln Ala Pro Arg Pro Ser Leu Trp Pro Glu Ile Gly Arg Pro Arg 
1               5                   10                  15      


Gly Cys 
        


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Arg Gly Pro Arg Ala Ala Gly Leu Thr Asp His Arg Gly Ile Gly His 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Arg Arg Leu Arg Ser Pro Ser Gly Ser Ser Thr Arg His Arg Arg His 
1               5                   10                  15      


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Leu Arg His Ser Phe Arg Ser Phe Ser Leu Glu Gly Arg Pro Lys 
1               5                   10                  15  


