                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Incorporated
 
<120>  RAN PROTEINS AS BIOMARKERS IN CAG/CTG EXPANSION DISORDERS

<130>  U1202.70072WO00

<140>  PCT/US2020/054976
<141>  2020-10-09

<150>  US 62/913,662
<151>  2019-10-09

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Ala 
            20  


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu 
        


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys Cys 
1               5                   10                  15      


Cys Cys Cys Cys 
            20  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  SITE
<222>  (1)..(1)
<223>  n repeats

<400>  5

Ala Ala Pro Ala Ala Ala Pro Ala Ala Thr Arg Pro Gly Cys Gly 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  SITE
<222>  (1)..(1)
<223>  n repeats

<400>  6

Ser Arg Pro Arg Arg His Pro Ala Arg Leu Trp Leu Arg Ser Arg 
1               5                   10                  15  


<210>  7
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  SITE
<222>  (1)..(1)
<223>  n repeats

<400>  7

Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu Pro Gln 
1               5                   10                  15      


Pro Pro Pro 
            


<210>  8
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  SITE
<222>  (3)..(51)
<223>  may be absent

<400>  8

Met Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu 
    50                  55                  60                  


Pro Gln Pro Pro Pro 
65                  


<210>  9
<211>  3
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n repeats

<400>  9
cag                                                                      3


<210>  10
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  n repeats

<400>  10
cagctg                                                                   6


<210>  11
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Ala Arg Arg Arg Asp Thr Arg Leu Ser Ser Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Ser Ile Ser Ile Ser Ser Ser Ser Ser Ser Ser Ser 
            20                  25                  30          


Ser Ser Ser Ser Ser Ser Thr Ser Ala Gly Leu Arg Gly Ser Ser Pro 
        35                  40                  45              


Arg Gly Pro Pro His Gln Pro Ser Arg Thr Ser Thr Ser Thr Phe Pro 
    50                  55                  60                  


Val Leu Arg Arg Thr Pro Ala Ala Pro Pro Leu Leu Arg Pro Ser Pro 
65                  70                  75                  80  


Ser Thr Ser Thr Pro Thr Arg Arg 
                85              


<210>  12
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Ser Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asn 
1               5                   10                  15      


Ser Ser Ser Ser Ser Ser Ser Ser Ser Arg Arg Pro Arg Leu Pro Met 
            20                  25                  30          


Ser Ala Ser Pro Ala Ala Ala Ala Phe 
        35                  40      


<210>  13
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  SITE
<222>  (1)..(1)
<223>  may repeat between 2 and n times

<400>  13

Ser Asn Ser Ser Ser Ser Ser Ser Ser Arg Gly Thr Tyr Gln Asp Arg 
1               5                   10                  15      


Val His Ile His Val Lys Gly Gln Pro Pro Val Gln Glu His Leu Gly 
            20                  25                  30          


Val Ile 
        


<210>  14
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Ser Ser Asn Ser Ser Ser Ser Ser Ser Ser Arg Gly Thr Tyr Gln Asp 
1               5                   10                  15      


Arg Val His Ile His Val Lys Gly Gln Pro Pro Val Gln Glu His Leu 
            20                  25                  30          


Gly Val Ile Arg Ala Gly Arg Pro Pro Ala Ala Leu Gly Gly Thr Gln 
        35                  40                  45              


Ala Pro Arg Pro Ser Leu Trp Pro Glu Ile Gly Arg Pro Arg Gly Ala 
    50                  55                  60                  


Thr Ala Ala Ala Ala Arg Pro Gly Trp Arg Gly Gly Ser Gln Ala Arg 
65                  70                  75                  80  


Pro Gly Ala Ser Pro Pro Gly Pro Val Asp Thr Ala Gly Pro Gly Gly 
                85                  90                  95      


Arg His Leu Ala Arg Thr Cys Pro Arg Gly Pro Arg Val Pro Gly Thr 
            100                 105                 110         


Met Ala Thr Thr Gly Ala Pro Thr Thr Thr Arg Pro Met Ala Arg Ala 
        115                 120                 125             


Ala Gly Ala Ala Arg Arg Pro Trp Pro Gly Pro Thr Thr Arg His Pro 
    130                 135                 140                 


Pro Tyr Asp Thr Arg Pro Arg Ala Pro Pro Gly Ala Arg Pro Gly Leu 
145                 150                 155                 160 


Pro Gly Pro Arg Ala Arg Pro Ala Pro Arg Leu Leu Gly Thr Ala Gly 
                165                 170                 175     


Asp Ser Pro Thr Ala Thr Thr Arg Arg Thr Asp Trp Pro Gly Pro Ala 
            180                 185                 190         


Gly Arg Ala Pro Gly Arg Ala Cys Thr Asn Pro Thr Ala Arg Val Thr 
        195                 200                 205             


Met Ile Gly Ala 
    210         


<210>  15
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15
aggccggcgg ctcggggccc ccgcagcagc agcagcaggc ggtggccagg ccgggccggg       60

cggccaccag cggccctcgg aggtacccag gccccacggc cgagcctctg gccggagatc      120

ggccgcccac ggggggccac agcagcggcc gctcgcccag gatggagagg cgggtcccag      180

gcccggcccg gagcgagtcc cccagggcct gtcgacacgg cggggcccgg tggccggcat      240

ctggcccgca cgtgtccgag gggcccccgg gtccccggca ccatggctac taccggggct      300

ccgactacga cgaggccgat ggcccgggca gcgggggcgg cgaggaggcc atggccgggg      360

cctacgacgc gccacccccc gtacgacacg cgtcctcggg cgccaccggg cgctcgccca      420

ggactccccg ggcctcgggc ccggcctgcg cctcgccttc tcggcacggc cggcgactcc      480

ccaacggcta ctacccggcg cacggactgg ccaggccccg cgggccgggc tccaggaagg      540

gcctgcacga accctacagc gagagtgacg atgattggtg caggatccct cgaggactac      600

aaagaccacg acggagatta caaagatcac gacatcgatt acaaggacga cgacgacaag      660

taa                                                                    663


<210>  16
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Arg Gln Leu Pro Gly Phe 
1               5                   10                  15      


Arg Pro Arg Leu Cys Pro Glu Cys Gly Gly Ile Ser Val Arg Val Gly 
            20                  25                  30          


Leu Gly Pro Val Ala Val Leu Gln Pro Val Ala Pro Gly Pro Phe Val 
        35                  40                  45              


Phe Gly Pro Val Ala Arg Ala Leu Pro His Pro Val Ala Pro Leu Glu 
    50                  55                  60                  


Ser Val Arg Pro Leu Ala Leu Val His Pro Leu Pro Leu Ala Leu Gln 
65                  70                  75                  80  


Ala Asp Ala Val Ala Leu Ala Leu Arg Pro Gly Ala Leu Val Arg Val 
                85                  90                  95      


Ala Ala Gly Pro Gly Val Asp Ala Gln His Leu Glu Ala Val Ala Pro 
            100                 105                 110         


Arg Ala Gly Val Phe Ala Leu Ala Leu Gly Ala Gly Ala Asp Ala Met 
        115                 120                 125             


Ala Val 
    130 


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Arg Gly Ser Ser Pro Arg Gly Pro Pro His Gln Pro Ser Arg Thr 
1               5                   10                  15  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Val Ser Arg Arg Leu Ala Gln Thr His Val Gly Gln Gln Ser 
1               5                   10                  


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Arg Arg Pro Arg Leu Pro Met Ser Ala Ser Pro Ala Ala Ala Ala Phe 
1               5                   10                  15      


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Gly Leu Gln Arg His Gly Glu Gly Pro Ile His Arg Leu Ala Arg 
1               5                   10                  15  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Gly Thr Tyr Gln Asp Arg Val His Ile His Val Lys Gly Gln 
1               5                   10                  


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Phe Phe Lys Val Gly Phe Ser Ser Leu Pro Lys Leu Phe 
1               5                   10              


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Thr Gln Ala Pro Arg Pro Ser Leu Trp Pro Glu Ile Gly Arg Pro Arg 
1               5                   10                  15      


Gly Cys 
        


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Arg Gly Pro Arg Ala Ala Gly Leu Thr Asp His Arg Gly Ile Gly His 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Arg Arg Leu Arg Ser Pro Ser Gly Ser Ser Thr Arg His Arg Arg His 
1               5                   10                  15      


<210>  26
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Leu Arg His Ser Phe Arg Ser Phe Ser Leu Glu Gly Arg Pro Lys 
1               5                   10                  15  


