                         SEQUENCE LISTING

<110>  Fred Hutchinson Cancer Research Center
 
<120>  Engineered Trimeric CD70 Proteins and Uses Thereof

<130>  F053-0106PCT/19-144-WO-PCT

<140>  PCT/US2020/054855
<141>  2020-10-08

<150>  US 62/912,510
<151>  2019-10-08

<150>  US 62/971,712
<151>  2020-02-07

<150>  US 62/984,695
<151>  2020-03-03

<160>  215   

<170>  PatentIn version 3.5

<210>  1
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  2
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys 
    


<210>  3
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile Cys 
1               5                   10                  15      


Leu Val Val Cys Ile 
            20      


<210>  4
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly 
1               5                   10                  15      


Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp 
            20                  25                  30          


Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu 
        35                  40                  45              


His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly 
    50                  55                  60                  


Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
65                  70                  75                  80  


Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser 
                85                  90                  95      


Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly 
            100                 105                 110         


Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr 
        115                 120                 125             


Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp 
    130                 135                 140                 


Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro 
145                 150                 155 


<210>  5
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDT-000762-2: hsCD70_SC-His-Avi-Tev-Fc_hsIgG1

<400>  5

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu 
            20                  25                  30          


Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly 
        35                  40                  45              


Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly 
    50                  55                  60                  


Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
65                  70                  75                  80  


His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile 
                85                  90                  95      


Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val 
            100                 105                 110         


Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser 
        115                 120                 125             


Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala 
    130                 135                 140                 


Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
145                 150                 155                 160 


Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro Gly 
                165                 170                 175     


Ser Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu 
            180                 185                 190         


Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln 
        195                 200                 205             


Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe 
    210                 215                 220                 


Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp 
225                 230                 235                 240 


Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser 
                245                 250                 255     


Thr Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys 
            260                 265                 270         


Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln 
        275                 280                 285             


Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp 
    290                 295                 300                 


Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr 
305                 310                 315                 320 


Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro Gly Ser Gln Arg 
                325                 330                 335     


Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp 
            340                 345                 350         


Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg 
        355                 360                 365             


Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly 
    370                 375                 380                 


Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile Tyr 
385                 390                 395                 400 


Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr Thr Ala 
                405                 410                 415     


Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro Ala 
            420                 425                 430         


Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly Cys Thr 
        435                 440                 445             


Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys 
    450                 455                 460                 


Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr 
465                 470                 475                 480 


Phe Phe Gly Val Gln Trp Val Arg Pro Gly Gly Gly Gly Ser His His 
                485                 490                 495     


His His His His Gly Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln 
            500                 505                 510         


Lys Ile Glu Trp His Glu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly 
        515                 520                 525             


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            660                 665                 670         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  6
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  7
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDT-001100: hsCD70_SC-Toroidx6_SS_tetramer-His

<400>  7

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu 
            20                  25                  30          


Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly 
        35                  40                  45              


Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly 
    50                  55                  60                  


Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
65                  70                  75                  80  


His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile 
                85                  90                  95      


Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val 
            100                 105                 110         


Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser 
        115                 120                 125             


Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala 
    130                 135                 140                 


Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
145                 150                 155                 160 


Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro Gly 
                165                 170                 175     


Gly Ser Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser 
            180                 185                 190         


Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln 
        195                 200                 205             


Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser 
    210                 215                 220                 


Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg 
225                 230                 235                 240 


Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser 
                245                 250                 255     


Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile 
            260                 265                 270         


Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His 
        275                 280                 285             


Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly 
    290                 295                 300                 


Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn 
305                 310                 315                 320 


Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro Gly Gly Ser 
                325                 330                 335     


Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly 
            340                 345                 350         


Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp 
        355                 360                 365             


Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu 
    370                 375                 380                 


His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly 
385                 390                 395                 400 


Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
                405                 410                 415     


Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser 
            420                 425                 430         


Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly 
        435                 440                 445             


Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr 
    450                 455                 460                 


Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp 
465                 470                 475                 480 


Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly 
            500                 505                 510         


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
        515                 520                 525             


His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu 
    530                 535                 540                 


Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala 
545                 550                 555                 560 


Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu 
                565                 570                 575     


Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg 
            580                 585                 590         


Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala 
        595                 600                 605             


Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu 
    610                 615                 620                 


Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala 
625                 630                 635                 640 


Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu 
                645                 650                 655     


Leu Arg Ala Ala His Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala 
            660                 665                 670         


Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu 
        675                 680                 685             


Leu Leu Arg Ala Ala His Glu Leu Gly Leu Gly Gly Ser His His His 
    690                 695                 700                 


His His His 
705         


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  8

Gly Gly Gly Ser 
1               


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His tag

<400>  9

His His His His His His 
1               5       


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avi tag

<400>  10

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tev within MDT-000762-2

<400>  11

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  12
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  13
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDT-000763: hsTetranectin_TD-hsCD70-His-Avi

<400>  13

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val Asn 
            20                  25                  30          


Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys Ser 
        35                  40                  45              


Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln Gln 
    50                  55                  60                  


Ala Leu Gln Thr Val Gly Gly Gly Gly Ser Gln Arg Phe Ala Gln Ala 
65                  70                  75                  80  


Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu 
                85                  90                  95      


Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln 
            100                 105                 110         


Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp 
        115                 120                 125             


Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile 
    130                 135                 140                 


Gln Val Thr Leu Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His 
145                 150                 155                 160 


Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile 
                165                 170                 175     


Ser Leu Leu Arg Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln 
            180                 185                 190         


Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr 
        195                 200                 205             


Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val 
    210                 215                 220                 


Gln Trp Val Arg Pro Gly Gly Gly Ser His His His His His His Gly 
225                 230                 235                 240 


Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
                245                 250                 


<210>  14
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val Asn Ala Lys Lys Asp 
1               5                   10                  15      


Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys Ser Arg Leu Asp Thr 
            20                  25                  30          


Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln Gln Ala Leu Gln Thr 
        35                  40                  45              


Val Gly Gly Gly Gly Ser 
    50                  


<210>  15
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MDT-000764-2: hsCD70-Collagen_TD-His-Avi

<400>  15

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu 
            20                  25                  30          


Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly 
        35                  40                  45              


Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly 
    50                  55                  60                  


Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile 
65                  70                  75                  80  


His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile 
                85                  90                  95      


Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val 
            100                 105                 110         


Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser 
        115                 120                 125             


Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala 
    130                 135                 140                 


Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser 
145                 150                 155                 160 


Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro Gly 
                165                 170                 175     


Ser Asn Leu Val Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys 
            180                 185                 190         


Ala His Leu Val Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr 
        195                 200                 205             


Glu Phe Phe Ile Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly 
    210                 215                 220                 


Glu Leu Ile Pro Ile Pro Ala Gly Ser His His His His His His Gly 
225                 230                 235                 240 


Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                245                 250                 255     


Glu 
    


<210>  16
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimer_Collagen-hsCD70

<400>  16

Met Glu Leu Trp Gly Ala Tyr Leu Leu Leu Cys Leu Phe Ser Leu Leu 
1               5                   10                  15      


Thr Gln Val Thr Thr Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val 
            20                  25                  30          


Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys 
        35                  40                  45              


Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln 
    50                  55                  60                  


Gln Ala Leu Gln Thr Val Cys Leu Lys Gly Gly Gly Gly Ser Gln Arg 
65                  70                  75                  80  


Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly Trp Asp 
                85                  90                  95      


Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp Pro Arg 
            100                 105                 110         


Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu His Gly 
        115                 120                 125             


Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly Ile Tyr 
    130                 135                 140                 


Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr Thr Ala 
145                 150                 155                 160 


Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser Pro Ala 
                165                 170                 175     


Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly Cys Thr 
            180                 185                 190         


Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr Leu Cys 
        195                 200                 205             


Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp Glu Thr 
    210                 215                 220                 


Phe Phe Gly Val Gln Trp Val Arg Pro Gly Gly Gly Ser His His His 
225                 230                 235                 240 


His His His Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
                245                 250                 255     


His Glu 
        


<210>  17
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hsCD70-hsCollagen_TD-Avi

<400>  17

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Glu His His His His His His Gly 
            20                  25                  30          


Gly Ser Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser 
        35                  40                  45              


Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys 
    50                  55                  60                  


Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys 
65                  70                  75                  80  


Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys 
                85                  90                  95      


Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr 
            100                 105                 110         


Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu 
        115                 120                 125             


Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val 
    130                 135                 140                 


Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val 
145                 150                 155                 160 


Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys 
                165                 170                 175     


Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser 
            180                 185                 190         


Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln 
        195                 200                 205             


Cys Ile Asp Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser 
    210                 215                 220                 


Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu Pro Leu Glu Ser Leu Gly 
225                 230                 235                 240 


Trp Asp Val Ala Glu Leu Gln Leu Asn His Thr Gly Pro Gln Gln Asp 
                245                 250                 255     


Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala Leu Gly Arg Ser Phe Leu 
            260                 265                 270         


His Gly Pro Glu Leu Asp Lys Gly Gln Leu Arg Ile His Arg Asp Gly 
        275                 280                 285             


Ile Tyr Met Val His Ile Gln Val Thr Leu Ala Ile Cys Ser Ser Thr 
    290                 295                 300                 


Thr Ala Ser Arg His His Pro Thr Thr Leu Ala Val Gly Ile Cys Ser 
305                 310                 315                 320 


Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg Leu Ser Phe His Gln Gly 
                325                 330                 335     


Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro Leu Ala Arg Gly Asp Thr 
            340                 345                 350         


Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu Pro Ser Arg Asn Thr Asp 
        355                 360                 365             


Glu Thr Phe Phe Gly Val Gln Trp Val Arg Pro Gly Ser Asn Leu Val 
    370                 375                 380                 


Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala His Leu Val 
385                 390                 395                 400 


Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu Phe Phe Ile 
                405                 410                 415     


Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu Leu Ile Pro 
            420                 425                 430         


Ile Pro Ala Gly Ser His His His His His His Gly Gly Ser Gly Leu 
        435                 440                 445             


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    450                 455                 460     


<210>  18
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Leu Trp Gly Ala Tyr Leu Leu Leu Cys Leu Phe Ser Leu Leu 
1               5                   10                  15      


Thr Gln Val Thr Thr 
            20      


<210>  19
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val Asn Ala Lys Lys Asp 
1               5                   10                  15      


Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys Ser Arg Leu Asp Thr 
            20                  25                  30          


Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln Gln Ala Leu Gln Thr 
        35                  40                  45              


Val Cys Leu Lys 
    50          


<210>  20
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  20

Asn Leu Val Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala 
1               5                   10                  15      


His Leu Val Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu 
            20                  25                  30          


Phe Phe Ile Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu 
        35                  40                  45              


Leu Ile Pro Ile Pro Ala 
    50                  


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  21

Gly Gly Gly Gly Ser 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sFLAG

<400>  22

Asp Tyr Lys Asp Glu 
1               5   


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tev

<400>  23

Glu Asn Leu Tyr Phe Gln Gly Gly Ser 
1               5                   


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  24

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  25
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP Scaffold

<400>  25

Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile Ser 
1               5                   10                  15      


Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly Leu 
            20                  25                  30          


Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly Ile 
        35                  40                  45              


Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu Gly 
    50                  55                  60                  


Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala Gly 
65                  70                  75                  80  


Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
                85                  90                  95      


Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
            100                 105                 110         


Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu 
        115                 120                 125             


Leu Gly Leu Asp Pro Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys 
    130                 135                 140                 


Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His 
145                 150                 155                 160 


Glu Leu Gly Leu Asp Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly 
                165                 170                 175     


Lys Ala Gly Ile Ser Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala 
            180                 185                 190         


His Glu Leu Gly Leu 
        195         


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP cysteine-modified N-terminal alpha-helix forming b segment

<400>  26

Cys Glu Ala Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  27
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP internal alpha-helix forming b and y segments

<400>  27

Ser Glu Glu Ile Leu Glu Leu Leu Arg Ala Ala His Glu Leu 
1               5                   10                  


<210>  28
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cTRP cysteine-modified C-terminal alpha-helix forming b segment

<400>  28

Pro Glu Cys Ile Lys Ala Ala Ala Glu Leu Gly Lys Ala 
1               5                   10              


<210>  29
<211>  2121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hsCD70_SC-Toroidx6_SS_tetramer-His

<400>  29
atggagaccg atacactgct gctgtgggtg ctgctgctgt gggtgcctgg cagcaccgga       60

cagcggttcg cacaggcaca gcagcagctg ccactggagt ccctgggatg ggacgtggca      120

gagctgcagc tgaaccacac aggcccccag caggacccca ggctgtactg gcagggcggc      180

cccgccctgg gccgctcctt tctgcacggc cctgagctgg acaagggcca gctgagaatc      240

cacagagatg gcatctatat ggtgcacatc caggtgaccc tggccatctg cagctccacc      300

acagcctctc ggcaccaccc aaccacactg gccgtgggca tctgtagccc agccagcagg      360

tccatctctc tgctgcgcct gtctttccac cagggatgca ccatcgccag ccagcggctg      420

acaccactgg ccagaggcga caccctgtgc acaaacctga ccggcacact gctgcccagc      480

cggaataccg atgagacatt ctttggcgtg cagtgggtga ggccaggagg ctctcagcgg      540

ttcgcccagg cccagcagca gctgcctctg gagagcctgg gctgggacgt ggccgagctg      600

cagctgaatc acaccggccc acagcaggac cccagactgt attggcaggg cggccctgcc      660

ctgggccgga gcttcctgca cggccccgag ctggacaagg gacagctgag aatccaccgc      720

gacggaatct atatggtcca tattcaagtg accctggcca tctgctctag caccacagcc      780

tccaggcatc atcctaccac actggccgtc ggcatctgtt ctcctgccag ccggtccatc      840

tctctgctga gactgtcctt tcaccagggc tgcaccatcg cctctcagag gctgacacct      900

ctggcccgcg gcgacactct gtgcaccaac ctgactggca cactgctgcc atcccgcaac      960

actgatgaga cattctttgg agtgcagtgg gtgcggccag gaggctccca gagattcgcc     1020

caggctcagc agcagctgcc cctggagtct ctgggctggg acgtggctga actgcagctg     1080

aaccataccg gccctcagca ggacccccgc ttatactggc agggcggccc agccctgggc     1140

cgcagctttc tgcacggccc cgaactggat aaagggcagc tgagaatcca cagggacgga     1200

atctatatgg tgcatattca ggtgaccctg gccatctgct cctctaccac agccagcagg     1260

caccacccta ccacactggc cgttggcatc tgttctcccg ccagcaggtc catctctctg     1320

ttacgcctga gcttccatca gggctgtact atcgcctccc agcggctgac acccctggcc     1380

agaggcgaca ctctgtgcac taacctgact ggcacactgt taccctcccg gaacactgac     1440

gagacattct ttggggtcca gtgggtgaga cctggaggag gaggatccgg cggaggaggc     1500

tcctgcgagg ccatcaaggc tgccgccgag ctgggcaagg caggcatcag ctccgaggag     1560

atcctggagc tgctgagggc agcacacgag ctgggcctgg accccgaagc catcaaggct     1620

gccgccgaac tgggcaaggc cggcatctct agcgaagaaa tcctggagct gctgagagcc     1680

gcccatgaac tgggcctgga ccccgaggcc atcaaggctg ccgccgagtt aggcaaggca     1740

ggcatctcct ctgaagagat cctggagtta ttaagagccg cccatgagct gggcctggac     1800

ccagaggcca tcaaggctgc cgccgagcta ggcaaggccg gcatcagctc cgaagaaatc     1860

ctggagttac tgagagccgc ccacgaatta ggcctggacc ccgaggccat caaggctgcc     1920

gccgagcttg gcaaggcagg catctctagc gaagagatcc tggagctttt aagagccgcc     1980

cacgaactgg gcctggaccc tgagtgtatc aaggctgccg ccgagctcgg caaggccggc     2040

atctcctctg aggaaatcct ggagttgtta cgcgccgccc acgagctggg cctgggcggc     2100

agccaccacc accaccacca c                                               2121


<210>  30
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val Asn Ala Lys Lys Asp 
1               5                   10                  15      


Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys Ser Arg Leu Asp Thr 
            20                  25                  30          


Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln Gln Ala Leu Gln Thr 
        35                  40                  45              


Val 
    


<210>  31
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val Asn Ala Lys Lys Asp 
1               5                   10                  15      


Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys Ser Arg Leu Asp Thr 
            20                  25                  30          


Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln Gln Ala Leu Gln Thr 
        35                  40                  45              


Val Cys Leu Lys Gly Thr Lys Val His Met Lys Cys Phe Leu Ala Phe 
    50                  55                  60                  


Thr Gln Thr Lys Thr Phe His Glu Ala Ser Glu Asp Cys Ile Ser Arg 
65                  70                  75                  80  


Gly Gly Thr Leu Ser Thr Pro Gln Thr Gly Ser Glu Asn Asp Ala Leu 
                85                  90                  95      


Tyr Glu Tyr Leu Arg Gln Ser Val Gly Asn Glu Ala Glu Ile Trp Leu 
            100                 105                 110         


Gly Leu Asn Asp Met Ala Ala Glu Gly Thr Trp Val Asp Met Thr Gly 
        115                 120                 125             


Ala Arg Ile Ala Tyr Lys Asn Trp Glu Thr Glu Ile Thr Ala Gln Pro 
    130                 135                 140                 


Asp Gly Gly Lys Thr Glu Asn Cys Ala Val Leu Ser Gly Ala Ala Asn 
145                 150                 155                 160 


Gly Lys Trp Phe Asp Lys Arg Cys Arg Asp Gln Leu Pro Tyr Ile Cys 
                165                 170                 175     


Gln Phe Gly Ile Val 
            180     


<210>  32
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  32

Val Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala His Leu 
1               5                   10                  15      


Val Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu Phe Phe 
            20                  25                  30          


Ile Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu Leu Ile 
        35                  40                  45              


Pro Ile Pro Ala Asp Ser Pro Pro Pro Pro Ala Leu Ser Ser Asn Pro 
    50                  55                  60                  


<210>  33
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Gly Val Arg Leu Trp Ala Thr Arg Gln Ala Met Leu Gly Gln Val 
1               5                   10                  15      


His Glu Val Pro Glu Gly Trp Leu Ile Phe Val Ala Glu Gln Glu Glu 
            20                  25                  30          


Leu Tyr Val Arg Val Gln Asn Gly Phe Arg Lys Val Gln Leu Glu Ala 
        35                  40                  45              


Arg Thr Pro Leu Pro Arg Gly Thr Asp Asn Glu 
    50                  55                  


<210>  34
<211>  125
<212>  PRT
<213>  Bos taurus

<400>  34

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Trp Lys Gln Ser Val Glu Leu Ala Lys Lys Asp 
            20                  25                  30          


Ser Leu Tyr Lys Asp Ala Met Gln Tyr Ala Ser Glu Ser Lys Asp Thr 
        35                  40                  45              


Glu Leu Ala Glu Glu Leu Leu Gln Trp Phe Leu Gln Glu Glu Lys Arg 
    50                  55                  60                  


Glu Cys Phe Gly Ala Cys Leu Phe Thr Cys Tyr Asp Leu Leu Arg Pro 
65                  70                  75                  80  


Asp Val Val Leu Glu Leu Ala Trp Arg His Asn Ile Met Asp Phe Ala 
                85                  90                  95      


Met Pro Tyr Phe Ile Gln Val Met Lys Glu Tyr Leu Thr Lys Val Asp 
            100                 105                 110         


Lys Leu Asp Ala Ser Glu Ser Leu Arg Lys Glu Glu Glu 
        115                 120                 125 


<210>  35
<211>  207
<212>  PRT
<213>  Salmonella enterica

<400>  35

Met Ser Asp Tyr Phe Ala Asp Lys His Leu Val Glu Glu Met Lys Glu 
1               5                   10                  15      


Gln Gln Lys Glu Gln Glu Thr Lys Ile Asn Leu Leu Glu Lys Gln Gln 
            20                  25                  30          


Lys Glu Gln Glu Ala Lys Ile Asn Leu Leu Glu Lys Gln Gln Ala Thr 
        35                  40                  45              


Ile Ile Asn Thr Thr Lys Lys Val Thr Glu Val Val Gly Arg Val Glu 
    50                  55                  60                  


Arg Lys Gln Arg Leu Phe Asp Tyr Thr Glu Leu Asp Pro Ser Gln Thr 
65                  70                  75                  80  


His Tyr Phe Ile Ile Asn Asn Gly Asn Ile Gly Leu Ala Gly Arg Ile 
                85                  90                  95      


Leu Ser Ile Glu Pro Ile Asp Asn Gly Ser Val Ile His Leu Asp Leu 
            100                 105                 110         


Val Asn Leu Leu Ser Ile Pro Val Ser Asn Leu Ala Phe Asn Met Thr 
        115                 120                 125             


Trp Gly Thr Lys Lys Pro Ser Glu Ala Lys Asp Leu Pro Arg Trp Lys 
    130                 135                 140                 


Gln Leu Leu Leu Asn Thr Lys Met Asp Ser Thr Ile Glu Leu Leu Pro 
145                 150                 155                 160 


Gly Ala Trp Thr Asn Val Thr Leu Thr Leu Lys Gly Val Ser Pro Asn 
                165                 170                 175     


Asn Leu Lys Tyr Leu Lys Ile Gly Ile Asp Met Glu Asn Val Ile Phe 
            180                 185                 190         


Asp Ser Ile Gln Pro Ile Asn Asp Thr Lys Lys Lys Pro Lys Lys 
        195                 200                 205         


<210>  36
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Ser Leu Asp Asp Ser Ile Ser Ala Ala Ser Thr Ser Asp Val Gln 
1               5                   10                  15      


Asp Arg Leu Ser Ala Leu Glu Ser Arg Val Gln Gln Gln Glu Asp Glu 
            20                  25                  30          


Met Thr Val Leu Lys Ala Ala Leu Ala Asp Val Leu Arg Arg Leu Ala 
        35                  40                  45              


Ile Ser Glu Asp His Val Ala Ser Val Lys Lys 
    50                  55                  


<210>  37
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  37

Cys Ala Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu 
1               5                   10                  15      


Leu Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Leu Ala 
            20                  25                  30          


Ile Leu Glu Asn Thr Val Val 
        35                  


<210>  38
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrilin-1 variant

<400>  38

Cys Ala Cys Glu Ser Leu Val Lys Phe Gln Ala Lys Val Glu Gly Leu 
1               5                   10                  15      


Ile Gln Ala Leu Thr Arg Lys Leu Glu Ala Val Ser Lys Arg Ile Ala 
            20                  25                  30          


Ile Leu Glu Asn Thr Val Val 
        35                  


<210>  39
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Ala Glu Ala Glu Val Thr Leu Arg Glu Leu Gln Glu Ala Leu Glu 
1               5                   10                  15      


Glu Glu Val Leu Thr Arg Gln Ser Leu Ser Arg Glu Met Glu Ala Ile 
            20                  25                  30          


Arg Thr Asp Asn Gln Asn Phe Ala Ser Gln Leu Arg Glu Ala Glu Ala 
        35                  40                  45              


Arg Asn Arg Asp Leu Glu Ala His Val Arg Gln Leu Gln Glu Arg Met 
    50                  55                  60                  


Glu Leu Leu Gln Ala Glu 
65                  70  


<210>  40
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMPK variant

<400>  40

Ile Ala Glu Ile Glu Val Thr Ile Arg Glu Leu Gln Glu Ala Ile Glu 
1               5                   10                  15      


Glu Glu Val Leu Thr Arg Gln Ser Leu Ser Arg Glu Ile Glu Ala Ile 
            20                  25                  30          


Arg Thr Asp Ile Gln Asn Ile Ala Ser Gln Leu Arg Glu Ile Glu Ala 
        35                  40                  45              


Arg Ile Arg Asp Leu Glu Ala His Val Arg Gln Leu Gln Glu Arg Met 
    50                  55                  60                  


Glu Leu Leu Gln Ala Glu 
65                  70  


<210>  41
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Ser Ala Leu Asn Thr Lys Ile Arg Ala Leu Gln Gly Ser Leu Glu 
1               5                   10                  15      


Asn Met Ser Lys Leu Leu Lys Arg Gln Asn Asp Ile Leu Gln Val Val 
            20                  25                  30          


Ser 
    


<210>  42
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Langerin

<400>  42

Ile Ser Ala Leu Asn Thr Lys Ile Arg Ala Ile Gln Gly Ser Ile Glu 
1               5                   10                  15      


Asn Met Ser Lys Leu Ile Lys Arg Gln Asn Asp Ile Ile Gln Val Val 
            20                  25                  30          


Ser 
    


<210>  43
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  43

Val Ser Arg Leu Glu Glu Glu Met Arg Lys Leu Gln Ala Thr Val Gln 
1               5                   10                  15      


Glu Leu Gln Lys Arg Leu Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
            20                  25                  30          


<210>  44
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronin 1a variant

<400>  44

Val Ser Arg Leu Glu Glu Glu Ile Arg Lys Leu Gln Ala Thr Val Gln 
1               5                   10                  15      


Glu Leu Gln Lys Arg Leu Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
            20                  25                  30          


<210>  45
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronin 1a variant

<400>  45

Val Ser Arg Ile Glu Glu Glu Ile Arg Lys Leu Gln Ala Thr Val Gln 
1               5                   10                  15      


Glu Leu Gln Lys Arg Leu Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
            20                  25                  30          


<210>  46
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronin 1a variant

<400>  46

Ile Ser Arg Ile Glu Glu Glu Ile Arg Lys Leu Gln Ala Thr Val Gln 
1               5                   10                  15      


Glu Leu Gln Lys Arg Leu Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
            20                  25                  30          


<210>  47
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronin 1a variant

<400>  47

Ile Ser Arg Ile Glu Glu Glu Ile Arg Lys Ile Gln Ala Thr Val Gln 
1               5                   10                  15      


Glu Leu Gln Lys Arg Leu Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
            20                  25                  30          


<210>  48
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronin 1a variant

<400>  48

Ile Ser Arg Ile Glu Glu Glu Ile Arg Lys Ile Gln Ala Thr Val Gln 
1               5                   10                  15      


Glu Leu Gln Lys Arg Ile Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
            20                  25                  30          


<210>  49
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronin 1a variant

<400>  49

Ile Ser Arg Ile Glu Glu Glu Ile Arg Lys Ile Asn Ala Thr Val Gln 
1               5                   10                  15      


Glu Leu Gln Lys Arg Ile Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
            20                  25                  30          


<210>  50
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Coronin 1a variant

<400>  50

Ile Ser Arg Ile Glu Glu Glu Ile Arg Lys Ile Asn Ala Thr Ile Gln 
1               5                   10                  15      


Glu Leu Gln Lys Arg Ile Asp Arg Leu Glu Glu Thr Val Gln Ala Lys 
            20                  25                  30          


<210>  51

<400>  51
000

<210>  52
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Arg Val Leu Ser Gly Thr Ser Leu Met Leu Cys Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Gln Ala Leu Cys Ser Pro Gly Leu Ala Pro Gln Ser Arg Gly 
            20                  25                  30          


His Leu Cys Arg Thr Arg Pro Thr Asp Leu Val Phe Val Val Asp Ser 
        35                  40                  45              


Ser Arg Ser Val Arg Pro Val Glu Phe Glu Lys Val Lys Val Phe Leu 
    50                  55                  60                  


Ser Gln Val Ile Glu Ser Leu Asp Val Gly Pro Asn Ala Thr Arg Val 
65                  70                  75                  80  


Gly Met Val Asn Tyr Ala Ser Thr Val Lys Gln Glu Phe Ser Leu Arg 
                85                  90                  95      


Ala His Val Ser Lys Ala Ala Leu Leu Gln Ala Val Arg Arg Ile Gln 
            100                 105                 110         


Pro Leu Ser Thr Gly Thr Met Thr Gly Leu Ala Ile Gln Phe Ala Ile 
        115                 120                 125             


Thr Lys Ala Phe Gly Asp Ala Glu Gly Gly Arg Ser Arg Ser Pro Asp 
    130                 135                 140                 


Ile Ser Lys Val Val Ile Val Val Thr Asp Gly Arg Pro Gln Asp Ser 
145                 150                 155                 160 


Val Gln Asp Val Ser Ala Arg Ala Arg Ala Ser Gly Val Glu Leu Phe 
                165                 170                 175     


Ala Ile Gly Val Gly Ser Val Asp Lys Ala Thr Leu Arg Gln Ile Ala 
            180                 185                 190         


Ser Glu Pro Gln Asp Glu His Val Asp Tyr Val Glu Ser Tyr Ser Val 
        195                 200                 205             


Ile Glu Lys Leu Ser Arg Lys Phe Gln Glu Ala Phe Cys Val Val Ser 
    210                 215                 220                 


Asp Leu Cys Ala Thr Gly Asp His Asp Cys Glu Gln Val Cys Ile Ser 
225                 230                 235                 240 


Ser Pro Gly Ser Tyr Thr Cys Ala Cys His Glu Gly Phe Thr Leu Asn 
                245                 250                 255     


Ser Asp Gly Lys Thr Cys Asn Val Cys Ser Gly Gly Gly Gly Ser Ser 
            260                 265                 270         


Ala Thr Asp Leu Val Phe Leu Ile Asp Gly Ser Lys Ser Val Arg Pro 
        275                 280                 285             


Glu Asn Phe Glu Leu Val Lys Lys Phe Ile Ser Gln Ile Val Asp Thr 
    290                 295                 300                 


Leu Asp Val Ser Asp Lys Leu Ala Gln Val Gly Leu Val Gln Tyr Ser 
305                 310                 315                 320 


Ser Ser Val Arg Gln Glu Phe Pro Leu Gly Arg Phe His Thr Lys Lys 
                325                 330                 335     


Asp Ile Lys Ala Ala Val Arg Asn Met Ser Tyr Met Glu Lys Gly Thr 
            340                 345                 350         


Met Thr Gly Ala Ala Leu Lys Tyr Leu Ile Asp Asn Ser Phe Thr Val 
        355                 360                 365             


Ser Ser Gly Ala Arg Pro Gly Ala Gln Lys Val Gly Ile Val Phe Thr 
    370                 375                 380                 


Asp Gly Arg Ser Gln Asp Tyr Ile Asn Asp Ala Ala Lys Lys Ala Lys 
385                 390                 395                 400 


Asp Leu Gly Phe Lys Met Phe Ala Val Gly Val Gly Asn Ala Val Glu 
                405                 410                 415     


Asp Glu Leu Arg Glu Ile Ala Ser Glu Pro Val Ala Glu His Tyr Phe 
            420                 425                 430         


Tyr Thr Ala Asp Phe Lys Thr Ile Asn Gln Ile Gly Lys Lys Leu Gln 
        435                 440                 445             


Lys Lys Ile Cys Val Glu Glu Asp Pro Cys Ala Cys Glu Ser Leu Val 
    450                 455                 460                 


Lys Phe Gln Ala Lys Val Glu Gly Leu Leu Gln Ala Leu Thr Arg Lys 
465                 470                 475                 480 


Leu Glu Ala Val Ser Lys Arg Leu Ala Ile Leu Glu Asn Thr Val Val 
                485                 490                 495     


<210>  53
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4 fibritin

<400>  53

Met Thr Asp Ile Val Leu Asn Asp Leu Pro Phe Val Asp Gly Pro Pro 
1               5                   10                  15      


Ala Glu Gly Gln Ser Arg Ile Ser Trp Ile Lys Asn Gly Glu Glu Ile 
            20                  25                  30          


Leu Gly Ala Asp Thr Gln Tyr Gly Ser Glu Gly Ser Met Asn Arg Pro 
        35                  40                  45              


Thr Val Ser Val Leu Arg Asn Val Glu Val Leu Asp Lys Asn Ile Gly 
    50                  55                  60                  


Ile Leu Lys Thr Ser Leu Glu Thr Ala Asn Ser Asp Ile Lys Thr Ile 
65                  70                  75                  80  


Gln Gly Ile Leu Asp Val Ser Gly Asp Ile Glu Ala Leu Ala Gln Ile 
                85                  90                  95      


Gly Ile Asn Lys Lys Asp Ile Ser Asp Leu Lys Thr Leu Thr Ser Glu 
            100                 105                 110         


His Thr Glu Ile Leu Asn Gly Thr Asn Asn Thr Val Asp Ser Ile Leu 
        115                 120                 125             


Ala Asp Ile Gly Pro Phe Asn Ala Glu Ala Asn Ser Val Tyr Arg Thr 
    130                 135                 140                 


Ile Arg Asn Asp Leu Leu Trp Ile Lys Arg Glu Leu Gly Gln Tyr Thr 
145                 150                 155                 160 


Gly Gln Asp Ile Asn Gly Leu Pro Val Val Gly Asn Pro Ser Ser Gly 
                165                 170                 175     


Met Lys His Arg Ile Ile Asn Asn Thr Asp Val Ile Thr Ser Gln Gly 
            180                 185                 190         


Ile Arg Leu Ser Glu Leu Glu Thr Lys Phe Ile Glu Ser Asp Val Gly 
        195                 200                 205             


Ser Leu Thr Ile Glu Val Gly Asn Leu Arg Glu Glu Leu Gly Pro Lys 
    210                 215                 220                 


Pro Pro Ser Phe Ser Gln Asn Val Tyr Ser Arg Leu Asn Glu Ile Asp 
225                 230                 235                 240 


Thr Lys Gln Thr Thr Val Glu Ser Asp Ile Ser Ala Ile Lys Thr Ser 
                245                 250                 255     


Ile Gly Tyr Pro Gly Asn Asn Ser Ile Ile Thr Ser Val Asn Thr Asn 
            260                 265                 270         


Thr Asp Asn Ile Ala Ser Ile Asn Leu Glu Leu Asn Gln Ser Gly Gly 
        275                 280                 285             


Ile Lys Gln Arg Leu Thr Val Ile Glu Thr Ser Ile Gly Ser Asp Asp 
    290                 295                 300                 


Ile Pro Ser Ser Ile Lys Gly Gln Ile Lys Asp Asn Thr Thr Ser Ile 
305                 310                 315                 320 


Glu Ser Leu Asn Gly Ile Val Gly Glu Asn Thr Ser Ser Gly Leu Arg 
                325                 330                 335     


Ala Asn Val Ser Trp Leu Asn Gln Ile Val Gly Thr Asp Ser Ser Gly 
            340                 345                 350         


Gly Gln Pro Ser Pro His Gly Ser Leu Leu Asn Arg Val Ser Thr Ile 
        355                 360                 365             


Glu Thr Ser Val Ser Gly Leu Asn Asn Ala Val Gln Asn Leu Gln Val 
    370                 375                 380                 


Glu Ile Gly Asn Asn Ser Ala Gly Ile Lys Gly Gln Val Val Ala Leu 
385                 390                 395                 400 


Asn Thr Leu Val Asn Gly Thr Asn Pro Asn Gly Ser Thr Val Glu Glu 
                405                 410                 415     


Arg Gly Leu Thr Asn Ser Ile Lys Ala Asn Glu Thr Asn Ile Ala Ser 
            420                 425                 430         


Val Thr Gln Glu Val Asn Thr Ala Lys Gly Asn Ile Ser Ser Leu Gln 
        435                 440                 445             


Gly Asp Val Gln Ala Leu Gln Glu Ala Gly Tyr Ile Pro Glu Ala Pro 
    450                 455                 460                 


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
465                 470                 475                 480 


Ser Thr Phe Leu Ser Pro Ala 
                485         


<210>  54
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization domain of T4 fibritin

<400>  54

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  55
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RB69 fibritin

<400>  55

Met Ile Glu Leu Lys Ser Leu Pro Tyr Val Asp Gly Pro Pro Asp Glu 
1               5                   10                  15      


Gly Gln Lys Arg Leu Asn Trp Ile Lys Asn Ser Glu Glu Ile Thr Gly 
            20                  25                  30          


Ala Asp Thr Leu Tyr Gly Ser Glu Gly Val Met Asn Arg Pro Ile Thr 
        35                  40                  45              


Glu Val Gln Arg Asn Val Glu Thr Ile Asn Asp Asn Val Lys Thr Ile 
    50                  55                  60                  


Ala Glu Ser Leu Asp Thr Ala Asn Ala Asp Ile Val Thr Ile Lys Ser 
65                  70                  75                  80  


Ile Leu Asp Val Ser Gly Asp Val Asp Ala Leu Ala Gln Ile Gly His 
                85                  90                  95      


Asn Thr Asp Asp Ile Glu Val Leu Lys His Thr Val Asn Ser His Gly 
            100                 105                 110         


Val Asp Ile Leu Asn Thr Glu Glu Lys Leu Asp Asp Thr Ile Ala Asn 
        115                 120                 125             


Ile Gly Val Val Asn Pro Glu Thr Asp Ser Val Tyr Arg Thr Val Arg 
    130                 135                 140                 


Asn Asp Leu Leu Trp Ile Lys Thr Glu Leu Gly Gln Tyr Thr Gly Gln 
145                 150                 155                 160 


Asp Ile Asn Gly Val Pro Thr Glu Gly Asn Glu Ser Thr Gly Met Lys 
                165                 170                 175     


Arg Arg Ile Ile Thr Asn Ser Ser Val Leu Val Asp Gln Gly Val Arg 
            180                 185                 190         


Leu Thr Glu Leu Glu Asn Lys Phe Ala Asp Ser Asp Val Gly Ala Leu 
        195                 200                 205             


Thr Thr Glu Val Glu Asn Leu Arg Gln Glu Ile Gly Pro Arg Pro Ser 
    210                 215                 220                 


Leu Thr Val Pro Val Tyr Thr Arg Leu Ser Gly Ile Asp Ser Ser Ile 
225                 230                 235                 240 


Ser Ile Gln Thr Arg Asp Ile Ala Ala Leu Lys Asp Phe Val Gly Tyr 
                245                 250                 255     


Pro Asn Ser Thr Ala Ile Lys Thr Gln Val Glu Ala Asn Arg Leu Ser 
            260                 265                 270         


Ile Ser Thr Ile Asn Ser Asp Ile Asn Ser Pro Gly Gly Ile Lys Pro 
        275                 280                 285             


Arg Leu Thr Thr Leu Glu Thr Thr Ile Gly Ser Pro Asp Leu Pro Thr 
    290                 295                 300                 


Thr Leu Gln Gly Lys Ile Lys Leu Asn Thr Asp Ser Ile Ser Gly Ile 
305                 310                 315                 320 


Asn Thr Val Leu Gly Val Asp Ser Ser Ser Gly Leu Arg Phe Asn Val 
                325                 330                 335     


Ala Trp Leu Asn Gln Val Val Gly Val Asp Ser Asn Gly Gly Gln Pro 
            340                 345                 350         


Glu Pro Ala Gly Ser Leu Leu Tyr Arg Thr Arg Ile Leu Glu Thr Gly 
        355                 360                 365             


Val Thr Asp Leu Gly Asn Asn Ile Gln Asn Val Gln Thr Glu Leu Gly 
    370                 375                 380                 


Thr Asn Ser Ser Gly Ile Lys Gly Gln Val Thr Ser Leu Asn Lys Leu 
385                 390                 395                 400 


Ile Ser Gly Thr Asn Pro Asn Gly Gln Thr Ile Glu Glu Arg Gly Ile 
                405                 410                 415     


Leu Pro Thr Val Lys Asn His Asp Thr Ser Ile Met Ala Leu Thr Thr 
            420                 425                 430         


Arg Val Thr Thr Leu Glu Thr Asp Leu Ala Ala Ala Glu Ala Glu Ile 
        435                 440                 445             


Gln Ala Leu Lys Glu Ala Gly Tyr Ile Glu Asp Ala Pro Ser Asp Gly 
    450                 455                 460                 


Lys Phe Tyr Val Arg Lys Asp Gly Ala Trp Val Glu Leu Pro Thr Ala 
465                 470                 475                 480 


<210>  56
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trimerization domain of RB69 fibritin

<400>  56

Gly Tyr Ile Glu Asp Ala Pro Ser Asp Gly Lys Phe Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Ala Trp Val Glu Leu Pro Thr Ala 
            20                  25      


<210>  57
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Ala Ala Ser Val Thr Pro Pro Gly Ser Leu Glu Leu Leu Gln 
1               5                   10                  15      


Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys Leu Glu Ala Lys Tyr 
            20                  25                  30          


Leu Cys Ser Ala Cys Arg Asn Val Leu Arg Arg Pro Phe Gln Ala Gln 
        35                  40                  45              


Cys Gly His Arg Tyr Cys Ser Phe Cys Leu Ala Ser Ile Leu Ser Ser 
    50                  55                  60                  


Gly Pro Gln Asn Cys Ala Ala Cys Val His Glu Gly Ile Tyr Glu Glu 
65                  70                  75                  80  


Gly Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe Pro Asp Asn Ala Ala 
                85                  90                  95      


Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys Pro Ser Asp Gly Cys 
            100                 105                 110         


Thr Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser Cys His Glu Gly Arg 
        115                 120                 125             


Cys Pro Leu Met Leu Thr Glu Cys Pro Ala Cys Lys Gly Leu Val Arg 
    130                 135                 140                 


Leu Gly Glu Lys Glu Arg His Leu Glu His Glu Cys Pro Glu Arg Ser 
145                 150                 155                 160 


Leu Ser Cys Arg His Cys Arg Ala Pro Cys Cys Gly Ala Asp Val Lys 
                165                 170                 175     


Ala His His Glu Val Cys Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys 
            180                 185                 190         


Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp His Val Lys Thr 
        195                 200                 205             


Cys Gly Lys Cys Arg Val Pro Cys Arg Phe His Ala Ile Gly Cys Leu 
    210                 215                 220                 


Glu Thr Val Glu Gly Glu Lys Gln Gln Glu His Glu Val Gln Trp Leu 
225                 230                 235                 240 


Arg Glu His Leu Ala Met Leu Leu Ser Ser Val Leu Glu Ala Lys Pro 
                245                 250                 255     


Leu Leu Gly Asp Gln Ser His Ala Gly Ser Glu Leu Leu Gln Arg Cys 
            260                 265                 270         


Glu Ser Leu Glu Lys Lys Thr Ala Thr Phe Glu Asn Ile Val Cys Val 
        275                 280                 285             


Leu Asn Arg Glu Val Glu Arg Val Ala Met Thr Ala Glu Ala Cys Ser 
    290                 295                 300                 


Arg Gln His Arg Leu Asp Gln Asp Lys Ile Glu Ala Leu Ser Ser Lys 
305                 310                 315                 320 


Val Gln Gln Leu Glu Arg Ser Ile Gly Leu Lys Asp Leu Ala Met Ala 
                325                 330                 335     


Asp Leu Glu Gln Lys Val Leu Glu Met Glu Ala Ser Thr Tyr Asp Gly 
            340                 345                 350         


Val Phe Ile Trp Lys Ile Ser Asp Phe Ala Arg Lys Arg Gln Glu Ala 
        355                 360                 365             


Val Ala Gly Arg Ile Pro Ala Ile Phe Ser Pro Ala Phe Tyr Thr Ser 
    370                 375                 380                 


Arg Tyr Gly Tyr Lys Met Cys Leu Arg Ile Tyr Leu Asn Gly Asp Gly 
385                 390                 395                 400 


Thr Gly Arg Gly Thr His Leu Ser Leu Phe Phe Val Val Met Lys Gly 
                405                 410                 415     


Pro Asn Asp Ala Leu Leu Arg Trp Pro Phe Asn Gln Lys Val Thr Leu 
            420                 425                 430         


Met Leu Leu Asp Gln Asn Asn Arg Glu His Val Ile Asp Ala Phe Arg 
        435                 440                 445             


Pro Asp Val Thr Ser Ser Ser Phe Gln Arg Pro Val Asn Asp Met Asn 
    450                 455                 460                 


Ile Ala Ser Gly Cys Pro Leu Phe Cys Pro Val Ser Lys Met Glu Ala 
465                 470                 475                 480 


Lys Asn Ser Tyr Val Arg Asp Asp Ala Ile Phe Ile Lys Ala Ile Val 
                485                 490                 495     


Asp Leu Thr Gly Leu 
            500     


<210>  58
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  59
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Arg Gly Leu Leu Cys Trp Pro Val Leu Leu Leu Leu Leu Gln Pro 
1               5                   10                  15      


Trp Glu Thr Gln Leu Gln Leu Thr Gly Pro Arg Cys His Thr Gly Pro 
            20                  25                  30          


Leu Asp Leu Val Phe Val Ile Asp Ser Ser Arg Ser Val Arg Pro Phe 
        35                  40                  45              


Glu Phe Glu Thr Met Arg Gln Phe Leu Met Gly Leu Leu Arg Gly Leu 
    50                  55                  60                  


Asn Val Gly Pro Asn Ala Thr Arg Val Gly Val Ile Gln Tyr Ser Ser 
65                  70                  75                  80  


Gln Val Gln Ser Val Phe Pro Leu Arg Ala Phe Ser Arg Arg Glu Asp 
                85                  90                  95      


Met Glu Arg Ala Ile Arg Asp Leu Val Pro Leu Ala Gln Gly Thr Met 
            100                 105                 110         


Thr Gly Leu Ala Ile Gln Tyr Ala Met Asn Val Ala Phe Ser Val Ala 
        115                 120                 125             


Glu Gly Ala Arg Pro Pro Glu Glu Arg Val Pro Arg Val Ala Val Ile 
    130                 135                 140                 


Val Thr Asp Gly Arg Pro Gln Asp Arg Val Ala Glu Val Ala Ala Gln 
145                 150                 155                 160 


Ala Arg Ala Arg Gly Ile Glu Ile Tyr Ala Val Gly Val Gln Arg Ala 
                165                 170                 175     


Asp Val Gly Ser Leu Arg Ala Met Ala Ser Pro Pro Leu Asp Glu His 
            180                 185                 190         


Val Phe Leu Val Glu Ser Phe Asp Leu Ile Gln Glu Phe Gly Leu Gln 
        195                 200                 205             


Phe Gln Ser Arg Leu Cys Gly Lys Asp Gln Cys Ala Glu Gly Gly His 
    210                 215                 220                 


Gly Cys Gln His Gln Cys Val Asn Ala Trp Ala Met Phe His Cys Thr 
225                 230                 235                 240 


Cys Asn Pro Gly Tyr Lys Leu Ala Ala Asp Asn Lys Ser Cys Leu Ala 
                245                 250                 255     


Ile Asp Leu Cys Ala Glu Gly Thr His Gly Cys Glu His His Cys Val 
            260                 265                 270         


Asn Ser Pro Gly Ser Tyr Phe Cys His Cys Gln Val Gly Phe Val Leu 
        275                 280                 285             


Gln Gln Asp Gln Arg Ser Cys Arg Ala Ile Asp Tyr Cys Ser Phe Gly 
    290                 295                 300                 


Asn His Ser Cys Gln His Glu Cys Val Ser Thr Pro Gly Gly Pro Arg 
305                 310                 315                 320 


Cys His Cys Arg Glu Gly His Asp Leu Gln Pro Asp Gly Arg Ser Cys 
                325                 330                 335     


Gln Val Arg Asp Leu Cys Asn Gly Val Asp His Gly Cys Glu Phe Gln 
            340                 345                 350         


Cys Val Ser Glu Gly Leu Ser Tyr Arg Cys Leu Cys Pro Glu Gly Arg 
        355                 360                 365             


Gln Leu Gln Ala Asp Gly Lys Ser Cys Asn Arg Cys Arg Glu Gly His 
    370                 375                 380                 


Val Asp Leu Val Leu Leu Val Asp Gly Ser Lys Ser Val Arg Pro Gln 
385                 390                 395                 400 


Asn Phe Glu Leu Val Lys Arg Phe Val Asn Gln Ile Val Asp Phe Leu 
                405                 410                 415     


Asp Val Ser Pro Glu Gly Thr Arg Val Gly Leu Val Gln Phe Ser Ser 
            420                 425                 430         


Arg Val Arg Thr Glu Phe Pro Leu Gly Arg Tyr Gly Thr Ala Ala Glu 
        435                 440                 445             


Val Lys Gln Ala Val Leu Ala Val Glu Tyr Met Glu Arg Gly Thr Met 
    450                 455                 460                 


Thr Gly Leu Ala Leu Arg His Met Val Glu His Ser Phe Ser Glu Ala 
465                 470                 475                 480 


Gln Gly Ala Arg Pro Arg Ala Leu Asn Val Pro Arg Val Gly Leu Val 
                485                 490                 495     


Phe Thr Asp Gly Arg Ser Gln Asp Asp Ile Ser Val Trp Ala Ala Arg 
            500                 505                 510         


Ala Lys Glu Glu Gly Ile Val Met Tyr Ala Val Gly Val Gly Lys Ala 
        515                 520                 525             


Val Glu Ala Glu Leu Arg Glu Ile Ala Ser Glu Pro Ala Glu Leu His 
    530                 535                 540                 


Val Ser Tyr Ala Pro Asp Phe Gly Thr Met Thr His Leu Leu Glu Asn 
545                 550                 555                 560 


Leu Arg Gly Ser Ile Cys Pro Glu Glu Gly Ile Ser Ala Gly Thr Glu 
                565                 570                 575     


Leu Arg Ser Pro Cys Glu Cys Glu Ser Leu Val Glu Phe Gln Gly Arg 
            580                 585                 590         


Thr Leu Gly Ala Leu Glu Ser Leu Thr Leu Asn Leu Ala Gln Leu Thr 
        595                 600                 605             


Ala Arg Leu Glu Asp Leu Glu Asn Gln Leu Ala Asn Gln Lys 
    610                 615                 620         


<210>  60
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heat shock transcription factor (HSF) (Accession No. AAX42211 
       [gi:61362386]

<400>  60

Met Asp Leu Pro Val Gly Pro Gly Ala Ala Gly Pro Ser Asn Val Pro 
1               5                   10                  15      


Ala Phe Leu Thr Lys Leu Trp Thr Leu Val Ser Asp Pro Asp Thr Asp 
            20                  25                  30          


Ala Leu Ile Cys Trp Ser Pro Ser Gly Asn Ser Phe His Val Phe Asp 
        35                  40                  45              


Gln Gly Gln Phe Ala Lys Glu Val Leu Pro Lys Tyr Phe Lys His Asn 
    50                  55                  60                  


Asn Met Ala Ser Phe Val Arg Gln Leu Asn Met Tyr Gly Phe Arg Lys 
65                  70                  75                  80  


Val Val His Ile Glu Gln Gly Gly Leu Val Lys Pro Glu Arg Asp Asp 
                85                  90                  95      


Thr Glu Phe Gln His Pro Cys Phe Leu Arg Gly Gln Glu Gln Leu Leu 
            100                 105                 110         


Glu Asn Ile Lys Arg Lys Val Thr Ser Val Ser Thr Leu Lys Ser Glu 
        115                 120                 125             


Asp Ile Lys Ile Arg Gln Asp Ser Val Thr Lys Leu Leu Thr Asp Val 
    130                 135                 140                 


Gln Leu Met Lys Gly Lys Gln Glu Cys Met Asp Ser Lys Leu Leu Ala 
145                 150                 155                 160 


Met Lys His Glu Asn Glu Ala Leu Trp Arg Glu Val Ala Ser Leu Arg 
                165                 170                 175     


Gln Lys His Ala Gln Gln Gln Lys Val Val Asn Lys Leu Ile Gln Phe 
            180                 185                 190         


Leu Ile Ser Leu Val Gln Ser Asn Arg Ile Leu Gly Val Lys Arg Lys 
        195                 200                 205             


Ile Pro Leu Met Leu Asn Asp Ser Gly Ser Ala His Ser Met Pro Lys 
    210                 215                 220                 


Tyr Ser Arg Gln Phe Ser Leu Glu His Val His Gly Ser Gly Pro Tyr 
225                 230                 235                 240 


Ser Ala Pro Ser Pro Ala Tyr Ser Ser Ser Ser Leu Tyr Ala Pro Asp 
                245                 250                 255     


Ala Val Ala Ser Ser Gly Pro Ile Ile Ser Asp Ile Thr Glu Leu Ala 
            260                 265                 270         


Pro Ala Ser Pro Met Ala Ser Pro Gly Gly Ser Ile Asp Glu Arg Pro 
        275                 280                 285             


Leu Ser Ser Ser Pro Leu Val Arg Val Lys Glu Glu Pro Pro Ser Pro 
    290                 295                 300                 


Pro Gln Ser Pro Arg Val Glu Glu Ala Ser Pro Gly Arg Pro Ser Ser 
305                 310                 315                 320 


Val Asp Thr Leu Leu Ser Pro Thr Ala Leu Ile Asp Ser Ile Leu Arg 
                325                 330                 335     


Glu Ser Glu Pro Ala Pro Ala Ser Val Thr Ala Leu Thr Asp Ala Arg 
            340                 345                 350         


Gly His Thr Asp Thr Glu Gly Arg Pro Pro Ser Pro Pro Pro Thr Ser 
        355                 360                 365             


Thr Pro Glu Lys Cys Leu Ser Val Ala Cys Leu Asp Lys Asn Glu Leu 
    370                 375                 380                 


Ser Asp His Leu Asp Ala Met Asp Ser Asn Leu Asp Asn Leu Gln Thr 
385                 390                 395                 400 


Met Leu Ser Ser His Gly Phe Ser Val Asp Thr Ser Ala Leu Leu Asp 
                405                 410                 415     


Leu Phe Ser Pro Ser Val Thr Val Pro Asp Met Ser Leu Pro Asp Leu 
            420                 425                 430         


Asp Ser Ser Leu Ala Ser Ile Gln Glu Leu Leu Ser Pro Gln Glu Pro 
        435                 440                 445             


Pro Arg Pro Pro Glu Ala Glu Asn Ser Ser Pro Asp Ser Gly Lys Gln 
    450                 455                 460                 


Leu Val His Tyr Thr Ala Gln Pro Leu Phe Leu Leu Asp Pro Gly Ser 
465                 470                 475                 480 


Val Asp Thr Gly Ser Asn Asp Leu Pro Val Leu Phe Glu Leu Gly Glu 
                485                 490                 495     


Gly Ser Tyr Phe Ser Glu Gly Asp Gly Phe Ala Glu Asp Pro Thr Ile 
            500                 505                 510         


Ser Leu Leu Thr Gly Ser Glu Pro Pro Lys Ala Lys Asp Pro Thr Val 
        515                 520                 525             


Ser 
    


<210>  61
<211>  3623
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ile Phe Ala Glu Val Asn Gly Glu Ala Gly Glu Leu Glu Leu Gln Arg 
            20                  25                  30          


Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg 
        35                  40                  45              


Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg 
    50                  55                  60                  


Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu 
65                  70                  75                  80  


Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys 
                85                  90                  95      


Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln 
            100                 105                 110         


Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln 
        115                 120                 125             


Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly 
    130                 135                 140                 


Gly Thr Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro 
145                 150                 155                 160 


Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile 
                165                 170                 175     


Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn 
            180                 185                 190         


Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro 
        195                 200                 205             


Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg 
    210                 215                 220                 


Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu 
225                 230                 235                 240 


Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Phe Ser Pro Asn 
                245                 250                 255     


Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly 
            260                 265                 270         


Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr 
        275                 280                 285             


Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu 
    290                 295                 300                 


Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro 
305                 310                 315                 320 


Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys 
                325                 330                 335     


Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile 
            340                 345                 350         


Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser 
        355                 360                 365             


Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly 
    370                 375                 380                 


Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu 
385                 390                 395                 400 


Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr 
                405                 410                 415     


Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn 
            420                 425                 430         


Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val 
        435                 440                 445             


Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly 
    450                 455                 460                 


Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly 
465                 470                 475                 480 


Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His 
                485                 490                 495     


Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu 
            500                 505                 510         


Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro 
        515                 520                 525             


His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln 
    530                 535                 540                 


Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser 
545                 550                 555                 560 


Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly 
                565                 570                 575     


Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly 
            580                 585                 590         


Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly 
        595                 600                 605             


Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro 
    610                 615                 620                 


Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His 
625                 630                 635                 640 


Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr 
                645                 650                 655     


Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro 
            660                 665                 670         


Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser 
        675                 680                 685             


Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser 
    690                 695                 700                 


Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe 
705                 710                 715                 720 


Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr 
                725                 730                 735     


Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His 
            740                 745                 750         


Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val 
        755                 760                 765             


Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile 
    770                 775                 780                 


Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile 
785                 790                 795                 800 


Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala 
                805                 810                 815     


Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe 
            820                 825                 830         


Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln 
        835                 840                 845             


Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly 
    850                 855                 860                 


Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser 
865                 870                 875                 880 


Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro 
                885                 890                 895     


Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys 
            900                 905                 910         


Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu 
        915                 920                 925             


Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln 
    930                 935                 940                 


Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp 
945                 950                 955                 960 


His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr 
                965                 970                 975     


Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val 
            980                 985                 990         


Tyr Asp Thr Asp Ser Glu Thr Ser  Leu Gly Arg Tyr Cys  Gly Lys Ser 
        995                 1000                 1005             


Ile Pro  Pro Ser Leu Thr Ser  Ser Gly Asn Ser Leu  Met Leu Val 
    1010                 1015                 1020             


Phe Val  Thr Asp Ser Asp Leu  Ala Tyr Glu Gly Phe  Leu Ile Asn 
    1025                 1030                 1035             


Tyr Glu  Ala Ile Ser Ala Ala  Thr Ala Cys Leu Gln  Asp Tyr Thr 
    1040                 1045                 1050             


Asp Asp  Leu Gly Thr Phe Thr  Ser Pro Asn Phe Pro  Asn Asn Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Trp Glu Cys Ile  Tyr Arg Ile Thr Val  Arg Thr Gly 
    1070                 1075                 1080             


Gln Leu  Ile Ala Val His Phe  Thr Asn Phe Ser Leu  Glu Glu Ala 
    1085                 1090                 1095             


Ile Gly  Asn Tyr Tyr Thr Asp  Phe Leu Glu Ile Arg  Asp Gly Gly 
    1100                 1105                 1110             


Tyr Glu  Lys Ser Pro Leu Leu  Gly Ile Phe Tyr Gly  Ser Asn Leu 
    1115                 1120                 1125             


Pro Pro  Thr Ile Ile Ser His  Ser Asn Lys Leu Trp  Leu Lys Phe 
    1130                 1135                 1140             


Lys Ser  Asp Gln Ile Asp Thr  Arg Ser Gly Phe Ser  Ala Tyr Trp 
    1145                 1150                 1155             


Asp Gly  Ser Ser Thr Gly Cys  Gly Gly Asn Leu Thr  Thr Ser Ser 
    1160                 1165                 1170             


Gly Thr  Phe Ile Ser Pro Asn  Tyr Pro Met Pro Tyr  Tyr His Ser 
    1175                 1180                 1185             


Ser Glu  Cys Tyr Trp Trp Leu  Lys Ser Ser His Gly  Ser Ala Phe 
    1190                 1195                 1200             


Glu Leu  Glu Phe Lys Asp Phe  His Leu Glu His His  Pro Asn Cys 
    1205                 1210                 1215             


Thr Leu  Asp Tyr Leu Ala Val  Tyr Asp Gly Pro Ser  Ser Asn Ser 
    1220                 1225                 1230             


His Leu  Leu Thr Gln Leu Cys  Gly Asp Glu Lys Pro  Pro Leu Ile 
    1235                 1240                 1245             


Arg Ser  Ser Gly Asp Ser Met  Phe Ile Lys Leu Arg  Thr Asp Glu 
    1250                 1255                 1260             


Gly Gln  Gln Gly Arg Gly Phe  Lys Ala Glu Tyr Arg  Gln Thr Cys 
    1265                 1270                 1275             


Glu Asn  Val Val Ile Val Asn  Gln Thr Tyr Gly Ile  Leu Glu Ser 
    1280                 1285                 1290             


Ile Gly  Tyr Pro Asn Pro Tyr  Ser Glu Asn Gln His  Cys Asn Trp 
    1295                 1300                 1305             


Thr Ile  Arg Ala Thr Thr Gly  Asn Thr Val Asn Tyr  Thr Phe Leu 
    1310                 1315                 1320             


Ala Phe  Asp Leu Glu His His  Ile Asn Cys Ser Thr  Asp Tyr Leu 
    1325                 1330                 1335             


Glu Leu  Tyr Asp Gly Pro Arg  Gln Met Gly Arg Tyr  Cys Gly Val 
    1340                 1345                 1350             


Asp Leu  Pro Pro Pro Gly Ser  Thr Thr Ser Ser Lys  Leu Gln Val 
    1355                 1360                 1365             


Leu Leu  Leu Thr Asp Gly Val  Gly Arg Arg Glu Lys  Gly Phe Gln 
    1370                 1375                 1380             


Met Gln  Trp Phe Val Tyr Gly  Cys Gly Gly Glu Leu  Ser Gly Ala 
    1385                 1390                 1395             


Thr Gly  Ser Phe Ser Ser Pro  Gly Phe Pro Asn Arg  Tyr Pro Pro 
    1400                 1405                 1410             


Asn Lys  Glu Cys Ile Trp Tyr  Ile Arg Thr Asp Pro  Gly Ser Ser 
    1415                 1420                 1425             


Ile Gln  Leu Thr Ile His Asp  Phe Asp Val Glu Tyr  His Ser Arg 
    1430                 1435                 1440             


Cys Asn  Phe Asp Val Leu Glu  Ile Tyr Gly Gly Pro  Asp Phe His 
    1445                 1450                 1455             


Ser Pro  Arg Ile Ala Gln Leu  Cys Thr Gln Arg Ser  Pro Glu Asn 
    1460                 1465                 1470             


Pro Met  Gln Val Ser Ser Thr  Gly Asn Glu Leu Ala  Ile Arg Phe 
    1475                 1480                 1485             


Lys Thr  Asp Leu Ser Ile Asn  Gly Arg Gly Phe Asn  Ala Ser Trp 
    1490                 1495                 1500             


Gln Ala  Val Thr Gly Gly Cys  Gly Gly Ile Phe Gln  Ala Pro Ser 
    1505                 1510                 1515             


Gly Glu  Ile His Ser Pro Asn  Tyr Pro Ser Pro Tyr  Arg Ser Asn 
    1520                 1525                 1530             


Thr Asp  Cys Ser Trp Val Ile  Arg Val Asp Arg Asn  His Arg Val 
    1535                 1540                 1545             


Leu Leu  Asn Phe Thr Asp Phe  Asp Leu Glu Pro Gln  Asp Ser Cys 
    1550                 1555                 1560             


Ile Met  Ala Tyr Asp Gly Leu  Ser Ser Thr Met Ser  Arg Leu Ala 
    1565                 1570                 1575             


Arg Thr  Cys Gly Arg Glu Gln  Leu Ala Asn Pro Ile  Val Ser Ser 
    1580                 1585                 1590             


Gly Asn  Ser Leu Phe Leu Arg  Phe Gln Ser Gly Pro  Ser Arg Gln 
    1595                 1600                 1605             


Asn Arg  Gly Phe Arg Ala Gln  Phe Arg Gln Ala Cys  Gly Gly His 
    1610                 1615                 1620             


Ile Leu  Thr Ser Ser Phe Asp  Thr Val Ser Ser Pro  Arg Phe Pro 
    1625                 1630                 1635             


Ala Asn  Tyr Pro Asn Asn Gln  Asn Cys Ser Trp Ile  Ile Gln Ala 
    1640                 1645                 1650             


Gln Pro  Pro Leu Asn His Ile  Thr Leu Ser Phe Thr  His Phe Glu 
    1655                 1660                 1665             


Leu Glu  Arg Ser Thr Thr Cys  Ala Arg Asp Phe Val  Glu Ile Leu 
    1670                 1675                 1680             


Asp Gly  Gly His Glu Asp Ala  Pro Leu Arg Gly Arg  Tyr Cys Gly 
    1685                 1690                 1695             


Thr Asp  Met Pro His Pro Ile  Thr Ser Phe Ser Ser  Ala Leu Thr 
    1700                 1705                 1710             


Leu Arg  Phe Val Ser Asp Ser  Ser Ile Ser Ala Gly  Gly Phe His 
    1715                 1720                 1725             


Thr Thr  Val Thr Ala Ser Val  Ser Ala Cys Gly Gly  Thr Phe Tyr 
    1730                 1735                 1740             


Met Ala  Glu Gly Ile Phe Asn  Ser Pro Gly Tyr Pro  Asp Ile Tyr 
    1745                 1750                 1755             


Pro Pro  Asn Val Glu Cys Val  Trp Asn Ile Val Ser  Ser Pro Gly 
    1760                 1765                 1770             


Asn Arg  Leu Gln Leu Ser Phe  Ile Ser Phe Gln Leu  Glu Asp Ser 
    1775                 1780                 1785             


Gln Asp  Cys Ser Arg Asp Phe  Val Glu Ile Arg Glu  Gly Asn Ala 
    1790                 1795                 1800             


Thr Gly  His Leu Val Gly Arg  Tyr Cys Gly Asn Ser  Phe Pro Leu 
    1805                 1810                 1815             


Asn Tyr  Ser Ser Ile Val Gly  His Thr Leu Trp Val  Arg Phe Ile 
    1820                 1825                 1830             


Ser Asp  Gly Ser Gly Ser Gly  Thr Gly Phe Gln Ala  Thr Phe Met 
    1835                 1840                 1845             


Lys Ile  Phe Gly Asn Asp Asn  Ile Val Gly Thr His  Gly Lys Val 
    1850                 1855                 1860             


Ala Ser  Pro Phe Trp Pro Glu  Asn Tyr Pro His Asn  Ser Asn Tyr 
    1865                 1870                 1875             


Gln Trp  Thr Val Asn Val Asn  Ala Ser His Val Val  His Gly Arg 
    1880                 1885                 1890             


Ile Leu  Glu Met Asp Ile Glu  Glu Ile Gln Asn Cys  Tyr Tyr Asp 
    1895                 1900                 1905             


Lys Leu  Arg Ile Tyr Asp Gly  Pro Ser Ile His Ala  Arg Leu Ile 
    1910                 1915                 1920             


Gly Ala  Tyr Cys Gly Thr Gln  Thr Glu Ser Phe Ser  Ser Thr Gly 
    1925                 1930                 1935             


Asn Ser  Leu Thr Phe His Phe  Tyr Ser Asp Ser Ser  Ile Ser Gly 
    1940                 1945                 1950             


Lys Gly  Phe Leu Leu Glu Trp  Phe Ala Val Asp Ala  Pro Asp Gly 
    1955                 1960                 1965             


Val Leu  Pro Thr Ile Ala Pro  Gly Ala Cys Gly Gly  Phe Leu Arg 
    1970                 1975                 1980             


Thr Gly  Asp Ala Pro Val Phe  Leu Phe Ser Pro Gly  Trp Pro Asp 
    1985                 1990                 1995             


Ser Tyr  Ser Asn Arg Val Asp  Cys Thr Trp Leu Ile  Gln Ala Pro 
    2000                 2005                 2010             


Asp Ser  Thr Val Glu Leu Asn  Ile Leu Ser Leu Asp  Ile Glu Ser 
    2015                 2020                 2025             


His Arg  Thr Cys Ala Tyr Asp  Ser Leu Val Ile Arg  Asp Gly Asp 
    2030                 2035                 2040             


Asn Asn  Leu Ala Gln Gln Leu  Ala Val Leu Cys Gly  Arg Glu Ile 
    2045                 2050                 2055             


Pro Gly  Pro Ile Arg Ser Thr  Gly Glu Tyr Met Phe  Ile Arg Phe 
    2060                 2065                 2070             


Thr Ser  Asp Ser Ser Val Thr  Arg Ala Gly Phe Asn  Ala Ser Phe 
    2075                 2080                 2085             


His Lys  Ser Cys Gly Gly Tyr  Leu His Ala Asp Arg  Gly Ile Ile 
    2090                 2095                 2100             


Thr Ser  Pro Lys Tyr Pro Glu  Thr Tyr Pro Ser Asn  Leu Asn Cys 
    2105                 2110                 2115             


Ser Trp  His Val Leu Val Gln  Ser Gly Leu Thr Ile  Ala Val His 
    2120                 2125                 2130             


Phe Glu  Gln Pro Phe Gln Ile  Pro Asn Gly Asp Ser  Ser Cys Asn 
    2135                 2140                 2145             


Gln Gly  Asp Tyr Leu Val Leu  Arg Asn Gly Pro Asp  Ile Cys Ser 
    2150                 2155                 2160             


Pro Pro  Leu Gly Pro Pro Gly  Gly Asn Gly His Phe  Cys Gly Ser 
    2165                 2170                 2175             


His Ala  Ser Ser Thr Leu Phe  Thr Ser Asp Asn Gln  Met Phe Val 
    2180                 2185                 2190             


Gln Phe  Ile Ser Asp His Ser  Asn Glu Gly Gln Gly  Phe Lys Ile 
    2195                 2200                 2205             


Lys Tyr  Glu Ala Lys Ser Leu  Ala Cys Gly Gly Asn  Val Tyr Ile 
    2210                 2215                 2220             


His Asp  Ala Asp Ser Ala Gly  Tyr Val Thr Ser Pro  Asn His Pro 
    2225                 2230                 2235             


His Asn  Tyr Pro Pro His Ala  Asp Cys Ile Trp Ile  Leu Ala Ala 
    2240                 2245                 2250             


Pro Pro  Glu Thr Arg Ile Gln  Leu Gln Phe Glu Asp  Arg Phe Asp 
    2255                 2260                 2265             


Ile Glu  Val Thr Pro Asn Cys  Thr Ser Asn Tyr Leu  Glu Leu Arg 
    2270                 2275                 2280             


Asp Gly  Val Asp Ser Asp Ala  Pro Ile Leu Ser Lys  Phe Cys Gly 
    2285                 2290                 2295             


Thr Ser  Leu Pro Ser Ser Gln  Trp Ser Ser Gly Glu  Val Met Tyr 
    2300                 2305                 2310             


Leu Arg  Phe Arg Ser Asp Asn  Ser Pro Thr His Val  Gly Phe Lys 
    2315                 2320                 2325             


Ala Lys  Tyr Ser Ile Ala Gln  Cys Gly Gly Arg Val  Pro Gly Gln 
    2330                 2335                 2340             


Ser Gly  Val Val Glu Ser Ile  Gly His Pro Thr Leu  Pro Tyr Arg 
    2345                 2350                 2355             


Asp Asn  Leu Phe Cys Glu Trp  His Leu Gln Gly Leu  Ser Gly His 
    2360                 2365                 2370             


Tyr Leu  Thr Ile Ser Phe Glu  Asp Phe Asn Leu Gln  Asn Ser Ser 
    2375                 2380                 2385             


Gly Cys  Glu Lys Asp Phe Val  Glu Ile Trp Asp Asn  His Thr Ser 
    2390                 2395                 2400             


Gly Asn  Ile Leu Gly Arg Tyr  Cys Gly Asn Thr Ile  Pro Asp Ser 
    2405                 2410                 2415             


Ile Asp  Thr Ser Ser Asn Thr  Ala Val Val Arg Phe  Val Thr Asp 
    2420                 2425                 2430             


Gly Ser  Val Thr Ala Ser Gly  Phe Arg Leu Arg Phe  Glu Ser Ser 
    2435                 2440                 2445             


Met Glu  Glu Cys Gly Gly Asp  Leu Gln Gly Ser Ile  Gly Thr Phe 
    2450                 2455                 2460             


Thr Ser  Pro Asn Tyr Pro Asn  Pro Asn Pro His Gly  Arg Ile Cys 
    2465                 2470                 2475             


Glu Trp  Arg Ile Thr Ala Pro  Glu Gly Arg Arg Ile  Thr Leu Met 
    2480                 2485                 2490             


Phe Asn  Asn Leu Arg Leu Ala  Thr His Pro Ser Cys  Asn Asn Glu 
    2495                 2500                 2505             


His Val  Ile Val Phe Asn Gly  Ile Arg Ser Asn Ser  Pro Gln Leu 
    2510                 2515                 2520             


Glu Lys  Leu Cys Ser Ser Val  Asn Val Ser Asn Glu  Ile Lys Ser 
    2525                 2530                 2535             


Ser Gly  Asn Thr Met Lys Val  Ile Phe Phe Thr Asp  Gly Ser Arg 
    2540                 2545                 2550             


Pro Tyr  Gly Gly Phe Thr Ala  Ser Tyr Thr Ser Ser  Glu Asp Ala 
    2555                 2560                 2565             


Val Cys  Gly Gly Ser Leu Pro  Asn Thr Pro Glu Gly  Asn Phe Thr 
    2570                 2575                 2580             


Ser Pro  Gly Tyr Asp Gly Val  Arg Asn Tyr Ser Arg  Asn Leu Asn 
    2585                 2590                 2595             


Cys Glu  Trp Thr Leu Ser Asn  Pro Asn Gln Gly Asn  Ser Ser Ile 
    2600                 2605                 2610             


Ser Ile  His Phe Glu Asp Phe  Tyr Leu Glu Ser His  Gln Asp Cys 
    2615                 2620                 2625             


Gln Phe  Asp Val Leu Glu Phe  Arg Val Gly Asp Ala  Asp Gly Pro 
    2630                 2635                 2640             


Leu Met  Trp Arg Leu Cys Gly  Pro Ser Lys Pro Thr  Leu Pro Leu 
    2645                 2650                 2655             


Val Ile  Pro Tyr Ser Gln Val  Trp Ile His Phe Val  Thr Asn Glu 
    2660                 2665                 2670             


Arg Val  Glu His Ile Gly Phe  His Ala Lys Tyr Ser  Phe Thr Asp 
    2675                 2680                 2685             


Cys Gly  Gly Ile Gln Ile Gly  Asp Ser Gly Val Ile  Thr Ser Pro 
    2690                 2695                 2700             


Asn Tyr  Pro Asn Ala Tyr Asp  Ser Leu Thr His Cys  Ser Ser Leu 
    2705                 2710                 2715             


Leu Glu  Ala Pro Gln Gly His  Thr Ile Thr Leu Thr  Phe Ser Asp 
    2720                 2725                 2730             


Phe Asp  Ile Glu Pro His Thr  Thr Cys Ala Trp Asp  Ser Val Thr 
    2735                 2740                 2745             


Val Arg  Asn Gly Gly Ser Pro  Glu Ser Pro Ile Ile  Gly Gln Tyr 
    2750                 2755                 2760             


Cys Gly  Asn Ser Asn Pro Arg  Thr Ile Gln Ser Gly  Ser Asn Gln 
    2765                 2770                 2775             


Leu Val  Val Thr Phe Asn Ser  Asp His Ser Leu Gln  Gly Gly Gly 
    2780                 2785                 2790             


Phe Tyr  Ala Thr Trp Asn Thr  Gln Thr Leu Gly Cys  Gly Gly Ile 
    2795                 2800                 2805             


Phe His  Ser Asp Asn Gly Thr  Ile Arg Ser Pro His  Trp Pro Gln 
    2810                 2815                 2820             


Asn Phe  Pro Glu Asn Ser Arg  Cys Ser Trp Thr Ala  Ile Thr His 
    2825                 2830                 2835             


Lys Ser  Lys His Leu Glu Ile  Ser Phe Asp Asn Asn  Phe Leu Ile 
    2840                 2845                 2850             


Pro Ser  Gly Asp Gly Gln Cys  Gln Asn Ser Phe Val  Lys Val Trp 
    2855                 2860                 2865             


Ala Gly  Thr Glu Glu Val Asp  Lys Ala Leu Leu Ala  Thr Gly Cys 
    2870                 2875                 2880             


Gly Asn  Val Ala Pro Gly Pro  Val Ile Thr Pro Ser  Asn Thr Phe 
    2885                 2890                 2895             


Thr Ala  Val Phe Gln Ser Gln  Glu Ala Pro Ala Gln  Gly Phe Ser 
    2900                 2905                 2910             


Ala Ser  Phe Val Ser Arg Cys  Gly Ser Asn Phe Thr  Gly Pro Ser 
    2915                 2920                 2925             


Gly Tyr  Ile Ile Ser Pro Asn  Tyr Pro Lys Gln Tyr  Asp Asn Asn 
    2930                 2935                 2940             


Met Asn  Cys Thr Tyr Val Ile  Glu Ala Asn Pro Leu  Ser Val Val 
    2945                 2950                 2955             


Leu Leu  Thr Phe Val Ser Phe  His Leu Glu Ala Arg  Ser Ala Val 
    2960                 2965                 2970             


Thr Gly  Ser Cys Val Asn Asp  Gly Val His Ile Ile  Arg Gly Tyr 
    2975                 2980                 2985             


Ser Val  Met Ser Thr Pro Phe  Ala Thr Val Cys Gly  Asp Glu Met 
    2990                 2995                 3000             


Pro Ala  Pro Leu Thr Ile Ala  Gly Pro Val Leu Leu  Asn Phe Tyr 
    3005                 3010                 3015             


Ser Asn  Glu Gln Ile Thr Asp  Phe Gly Phe Lys Phe  Ser Tyr Arg 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Gly Val  Phe Asn Phe Ser Ser  Gly Ile Ile 
    3035                 3040                 3045             


Thr Ser  Pro Ala Tyr Ser Tyr  Ala Asp Tyr Pro Asn  Asp Met His 
    3050                 3055                 3060             


Cys Leu  Tyr Thr Ile Thr Val  Ser Asp Asp Lys Val  Ile Glu Leu 
    3065                 3070                 3075             


Lys Phe  Ser Asp Phe Asp Val  Val Pro Ser Thr Ser  Cys Ser His 
    3080                 3085                 3090             


Asp Tyr  Leu Ala Ile Tyr Asp  Gly Ala Asn Thr Ser  Asp Pro Leu 
    3095                 3100                 3105             


Leu Gly  Lys Phe Cys Gly Ser  Lys Arg Pro Pro Asn  Val Lys Ser 
    3110                 3115                 3120             


Ser Asn  Asn Ser Met Leu Leu  Val Phe Lys Thr Asp  Ser Phe Gln 
    3125                 3130                 3135             


Thr Ala  Lys Gly Trp Lys Met  Ser Phe Arg Gln Thr  Leu Gly Pro 
    3140                 3145                 3150             


Gln Gln  Gly Cys Gly Gly Tyr  Leu Thr Gly Ser Asn  Asn Thr Phe 
    3155                 3160                 3165             


Ala Ser  Pro Asp Ser Asp Ser  Asn Gly Met Tyr Asp  Lys Asn Leu 
    3170                 3175                 3180             


Asn Cys  Val Trp Ile Ile Ile  Ala Pro Val Asn Lys  Val Ile His 
    3185                 3190                 3195             


Leu Thr  Phe Asn Thr Phe Ala  Leu Glu Ala Ala Ser  Thr Arg Gln 
    3200                 3205                 3210             


Arg Cys  Leu Tyr Asp Tyr Val  Lys Leu Tyr Asp Gly  Asp Ser Glu 
    3215                 3220                 3225             


Asn Ala  Asn Leu Ala Gly Thr  Phe Cys Gly Ser Thr  Val Pro Ala 
    3230                 3235                 3240             


Pro Phe  Ile Ser Ser Gly Asn  Phe Leu Thr Val Gln  Phe Ile Ser 
    3245                 3250                 3255             


Asp Leu  Thr Leu Glu Arg Glu  Gly Phe Asn Ala Thr  Tyr Thr Ile 
    3260                 3265                 3270             


Met Asp  Met Pro Cys Gly Gly  Thr Tyr Asn Ala Thr  Trp Thr Pro 
    3275                 3280                 3285             


Gln Asn  Ile Ser Ser Pro Asn  Ser Ser Asp Pro Asp  Val Pro Phe 
    3290                 3295                 3300             


Ser Ile  Cys Thr Trp Val Ile  Asp Ser Pro Pro His  Gln Gln Val 
    3305                 3310                 3315             


Lys Ile  Thr Val Trp Ala Leu  Gln Leu Thr Ser Gln  Asp Cys Thr 
    3320                 3325                 3330             


Gln Asn  Tyr Leu Gln Leu Gln  Asp Ser Pro Gln Gly  His Gly Asn 
    3335                 3340                 3345             


Ser Arg  Phe Gln Phe Cys Gly  Arg Asn Ala Ser Ala  Val Pro Val 
    3350                 3355                 3360             


Phe Tyr  Ser Ser Met Ser Thr  Ala Met Val Ile Phe  Lys Ser Gly 
    3365                 3370                 3375             


Val Val  Asn Arg Asn Ser Arg  Met Ser Phe Thr Tyr  Gln Ile Ala 
    3380                 3385                 3390             


Asp Cys  Asn Arg Asp Tyr His  Lys Ala Phe Gly Asn  Leu Arg Ser 
    3395                 3400                 3405             


Pro Gly  Trp Pro Asp Asn Tyr  Asp Asn Asp Lys Asp  Cys Thr Val 
    3410                 3415                 3420             


Thr Leu  Thr Ala Pro Gln Asn  His Thr Ile Ser Leu  Phe Phe His 
    3425                 3430                 3435             


Ser Leu  Gly Ile Glu Asn Ser  Val Glu Cys Arg Asn  Asp Phe Leu 
    3440                 3445                 3450             


Glu Val  Arg Asn Gly Ser Asn  Ser Asn Ser Pro Leu  Leu Gly Lys 
    3455                 3460                 3465             


Tyr Cys  Gly Thr Leu Leu Pro  Asn Pro Val Phe Ser  Gln Asn Asn 
    3470                 3475                 3480             


Glu Leu  Tyr Leu Arg Phe Lys  Ser Asp Ser Val Thr  Ser Asp Arg 
    3485                 3490                 3495             


Gly Tyr  Glu Ile Ile Trp Thr  Ser Ser Pro Ser Gly  Cys Gly Gly 
    3500                 3505                 3510             


Thr Leu  Tyr Gly Asp Arg Gly  Ser Phe Thr Ser Pro  Gly Tyr Pro 
    3515                 3520                 3525             


Gly Thr  Tyr Pro Asn Asn Thr  Tyr Cys Glu Trp Val  Leu Val Ala 
    3530                 3535                 3540             


Pro Ala  Gly Arg Leu Val Thr  Ile Asn Phe Tyr Phe  Ile Ser Ile 
    3545                 3550                 3555             


Asp Asp  Pro Gly Asp Cys Val  Gln Asn Tyr Leu Thr  Leu Tyr Asp 
    3560                 3565                 3570             


Gly Pro  Asn Ala Ser Ser Pro  Ser Ser Gly Pro Tyr  Cys Gly Gly 
    3575                 3580                 3585             


Asp Thr  Ser Ile Ala Pro Phe  Val Ala Ser Ser Asn  Gln Val Phe 
    3590                 3595                 3600             


Ile Lys  Phe His Ala Asp Tyr  Ala Arg Arg Pro Ser  Ala Phe Arg 
    3605                 3610                 3615             


Leu Thr  Trp Asp Ser 
    3620             


<210>  62
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  62

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      


Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln Gly Lys Trp Tyr 
            20                  25                  30          


Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              


Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  


Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  


Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      


Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         


Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             


Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 


Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 


Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     


Asp Gly 
        


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  63

Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10      


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  64

Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
1               5                   10  


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  65

Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  66

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  67
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  67

Leu Pro His Asp 
1               


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  68

Asn Pro Asn Asp 
1               


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  69

Asp Pro Lys Asp 
1               


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  70

Gly Leu Glu Pro Asp 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  71

Gly Val Ser Leu Asp 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  72

Gly Val Leu Pro Asp 
1               5   


<210>  73
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of huOKT3

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  74
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of huOKT3

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of huOKT3

<400>  75

Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10  


<210>  76
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of huOKT3

<400>  76

Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp 
1               5                   10                  15      


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of huOKT3

<400>  77

Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of huOKT3

<400>  78

Ser Ala Ser Ser Ser Val Ser Tyr Met Asn 
1               5                   10  


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of huOKT3

<400>  79

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of huOKT3

<400>  80

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  81
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of OKT3

<400>  81

Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
1               5                   10              


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of OKT3

<400>  82

Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10  


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of OKT3

<400>  83

Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
1               5                   10      


<210>  84
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv derived from OKT3

<400>  84

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Arg 
        


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 20G6-F3

<400>  85

Gln Ser Leu Val His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 20G6-F3

<400>  86

Gly Gln Gly Thr Gln Tyr Pro Phe Thr 
1               5                   


<210>  87
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 20G6-F3

<400>  87

Gly Phe Thr Phe Thr Lys Ala Trp 
1               5               


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 20G6-F3

<400>  88

Ile Lys Asp Lys Ser Asn Ser Tyr Ala Thr 
1               5                   10  


<210>  89
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 20G6-F3

<400>  89

Arg Gly Val Tyr Tyr Ala Leu Ser Pro Phe Asp Tyr 
1               5                   10          


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4B4-D7

<400>  90

Gln Ser Leu Val His Asp Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  91
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 4B4-D7

<400>  91

Gly Phe Thr Phe Ser Asn Ala Trp 
1               5               


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 4B4-D7

<400>  92

Ile Lys Ala Arg Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  93
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4B4-D7

<400>  93

Arg Gly Thr Tyr Tyr Ala Ser Lys Pro Phe Asp Tyr 
1               5                   10          


<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4E7-C9

<400>  94

Gln Ser Leu Glu His Asn Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 4E7-C9

<400>  95

Ile Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  96
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4E7-C9

<400>  96

Arg Tyr Val His Tyr Gly Ile Gly Tyr Ala Met Asp Ala 
1               5                   10              


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 18F5-H10

<400>  97

Gln Ser Leu Val His Thr Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 18F5-H10

<400>  98

Gly Gln Gly Thr His Tyr Pro Phe Thr 
1               5                   


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 18F5-H10

<400>  99

Gly Phe Thr Phe Thr Asn Ala Trp 
1               5               


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 18F5-H10

<400>  100

Lys Asp Lys Ser Asn Asn Tyr Ala Thr 
1               5                   


<210>  101
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 18F5-H10

<400>  101

Arg Tyr Val His Tyr Arg Phe Ala Tyr Ala Leu Asp Ala 
1               5                   10              


<210>  102
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of TGN1412

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  103
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of TGN1412

<400>  103

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Tyr Val Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Thr Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of TGN1412

<400>  104

His Ala Ser Gln Asn Ile Tyr Val Trp Leu Asn 
1               5                   10      


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of TGN1412

<400>  105

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of TGN1412

<400>  106

Gln Gln Gly Gln Thr Tyr Pro Tyr Thr 
1               5                   


<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of TGN1412

<400>  107

Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   10  


<210>  108
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of TGN1412

<400>  108

Ser Tyr Tyr Ile His 
1               5   


<210>  109
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2  of TGN1412

<400>  109

Cys Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Lys 
1               5                   10                  


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of TGN1412

<400>  110

Ser His Tyr Gly Leu Asp Trp Asn Phe Asp Val 
1               5                   10      


<210>  111
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of CD80/CD86 binding domain

<400>  111

Ser Val Ser Ser Ser Ile Ser Ser Ser Asn Leu His 
1               5                   10          


<210>  112
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of CD80/CD86 binding domain

<400>  112

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of CD80/CD86 binding domain

<400>  113

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of CD80/CD86 binding domain

<400>  114

Asp Tyr Tyr Met His 
1               5   


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of CD80/CD86 binding domain

<400>  115

Trp Ile Asp Pro Glu Asn Gly Asn Thr Leu Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of CD80/CD86 binding domain

<400>  116

Glu Gly Leu Phe Phe Ala Tyr 
1               5           


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4-1BB binding domain

<400>  117

Arg Ala Ser Gln Ser Val Ser 
1               5           


<210>  118
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 4-1BB binding domain

<400>  118

Ala Ser Asn Arg Ala Thr 
1               5       


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 4-1BB binding domain

<400>  119

Gln Arg Ser Asn Trp Pro Pro Ala Leu Thr 
1               5                   10  


<210>  120
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 4-1BB binding domain

<400>  120

Tyr Tyr Trp Ser 
1               


<210>  121
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4-1BB binding domain

<400>  121

Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  122
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of 4-1BB binding domain

<400>  122

Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala His 
1               5                   10      


<210>  123
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of 4-1BB binding domain

<400>  123

Gln Asp Lys Asn Arg Pro Ser 
1               5           


<210>  124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of 4-1BB binding domain

<400>  124

Ala Thr Tyr Thr Gly Phe Gly Ser Leu Ala Val 
1               5                   10      


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of 4-1BB binding domain

<400>  125

Gly Tyr Ser Phe Ser Thr Tyr Trp Ile Ser 
1               5                   10  


<210>  126
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of 4-1BB binding domain

<400>  126

Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser 
1               5                   10                  


<210>  127
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of 4-1BB binding domain

<400>  127

Gly Tyr Gly Ile Phe Asp Tyr 
1               5           


<210>  128
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  128

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  129
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  129

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90  


<210>  130
<211>  70
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  130

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        35                  40                  45              


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    50                  55                  60                  


Gly Gly Ser Gly Gly Ser 
65                  70  


<210>  131
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  131

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45  


<210>  132
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  132

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  133

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  134
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nef (66-97)

<400>  134

Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr Tyr 
1               5                   10                  15      


Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu 
            20                  25                  30          


<210>  135
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nef (116-145)

<400>  135

His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro 
1               5                   10                  15      


Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Leu Tyr Lys Leu 
            20                  25                  30  


<210>  136
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gag p17 (17-35)

<400>  136

Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
1               5                   10                  15      


His Ile Val 
            


<210>  137
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gag p17-p24 (253-284)

<400>  137

Asn Pro Pro Ile Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu 
1               5                   10                  15      


Gly Leu Asn Lys Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp 
            20                  25                  30          


<210>  138
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pol 325-355 (RT 158-188)

<400>  138

Ala Ile Phe Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Lys 
1               5                   10                  15      


Gln Asn Pro Asp Ile Val Ile Tyr Gln Tyr Met Asp Asp Leu Tyr 
            20                  25                  30      


<210>  139
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFV that binds human CD19

<400>  139

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Glu Val Lys Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro 
            20                  25                  30          


Gly Ser Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser 
        35                  40                  45              


Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly 
65                  70                  75                  80  


Lys Phe Lys Gly Gln Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Arg Lys Thr Ile Ser Ser Val Val Asp Phe Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Pro Leu Ile Tyr Ser Ala Thr Tyr 
        195                 200                 205             


Arg Asn Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser Lys Asp Leu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Tyr Asn Arg Tyr Pro Tyr Thr Ser Gly Gly Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Ile Glu Val Met Tyr Pro 
            260                 265                 270         


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
        275                 280                 285             


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
    290                 295                 300                 


Pro Phe Trp 
305         


<210>  140
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFV that binds human ROR1

<400>  140

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Glu Gln Leu Val Glu Ser Gly Gly Arg 
            20                  25                  30          


Leu Val Thr Pro Gly Gly Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Asp Phe Ser Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr 
65                  70                  75                  80  


Tyr Tyr Ala Thr Trp Val Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ala Gln Asn Thr Val Asp Leu Gln Met Asn Ser Leu Thr Ala Ala Asp 
            100                 105                 110         


Arg Ala Thr Tyr Phe Cys Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala 
        115                 120                 125             


Leu Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser Pro Ala 
                165                 170                 175     


Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp 
            180                 185                 190         


Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met Gln Val 
        195                 200                 205             


Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val 
225                 230                 235                 240 


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly 
                245                 250                 255     


Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Glu Ser 
            260                 265                 270         


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val 
        275                 280                 285             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300     


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 binding ROR1

<400>  141

Ala Ser Gly Phe Asp Phe Ser Ala Tyr Tyr Met 
1               5                   10      


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 binding ROR1

<400>  142

Thr Ile Tyr Pro Ser Ser Gly 
1               5           


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 binding ROR1

<400>  143

Ala Asp Arg Ala Thr Tyr Phe Cys Ala 
1               5                   


<210>  144
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 binding ROR1

<400>  144

Asp Thr Ile Asp Trp Tyr 
1               5       


<210>  145
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 binding ROR1

<400>  145

Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg 
1               5                   10                  15      


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 binding ROR1

<400>  146

Tyr Ile Gly Gly Tyr Val Phe Gly 
1               5               


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of R11

<400>  147

Gln Ala Ser Gln Ser Ile Asp Ser Asn Leu Ala 
1               5                   10      


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of R11

<400>  148

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  149
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of R11

<400>  149

Leu Gly Gly Val Gly Asn Val Ser Tyr Arg Thr Ser 
1               5                   10          


<210>  150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of R11

<400>  150

Asp Tyr Pro Ile Ser 
1               5   


<210>  151
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of R11

<400>  151

Phe Ile Asn Ser Gly Gly Ser Thr Trp Tyr Ala Ser Trp Val Lys Gly 
1               5                   10                  15      


<210>  152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of R11

<400>  152

Gly Tyr Ser Thr Tyr Tyr Cys Asp Phe Asn Ile 
1               5                   10      


<210>  153
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of R12

<400>  153

Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp 
1               5                   10          


<210>  154
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of R12

<400>  154

Gly Ser Tyr Thr Lys Arg Pro 
1               5           


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of R12

<400>  155

Gly Ala Asp Tyr Ile Gly Gly Tyr Val 
1               5                   


<210>  156
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of R12

<400>  156

Ala Tyr Tyr Met Ser 
1               5   


<210>  157
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of R12

<400>  157

Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  158
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of R12

<400>  158

Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile 
1               5                   10          


<210>  159
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain of scFV that binds human CD33

<400>  159

Asp Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Asn Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Asp Ser Pro Lys Arg Trp Ile Phe 
        35                  40                  45              


Asp Thr Ser Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Arg Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Asp Gly Thr Arg Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  160
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain of scFV that binds human CD33

<400>  160

Asp Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Asn Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Phe 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser His Pro Leu Thr 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Leu Gln Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  161
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain of Avelumab

<400>  161

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  162
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain of Avelumab

<400>  162

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of Avelumab

<400>  163

Ser Gly Phe Thr Phe Ser Ser Tyr Ile Met Met 
1               5                   10      


<210>  164
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of Avelumab

<400>  164

Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  165
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of Avelumab

<400>  165

Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr 
1               5                   10      


<210>  166
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of Avelumab

<400>  166

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  167
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of Avelumab

<400>  167

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  168
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of Avelumab

<400>  168

Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val 
1               5                   10  


<210>  169
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain of Atezolizumab

<400>  169

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  170
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain of Atezolizumab

<400>  170

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  171
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of Atezolizumab

<400>  171

Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His 
1               5                   10      


<210>  172
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of Atezolizumab

<400>  172

Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  173
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of Atezolizumab

<400>  173

Arg His Trp Pro Gly Gly Phe Asp Tyr 
1               5                   


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of Atezolizumab

<400>  174

Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala 
1               5                   10      


<210>  175
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of Atezolizumab

<400>  175

Ser Ala Ser Phe Leu Tyr Ser 
1               5           


<210>  176
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of Atezolizumab

<400>  176

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  177
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 that binds MUC16

<400>  177

Ser Glu Asp Ile Tyr Ser Gly 
1               5           


<210>  178
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 that binds MUC16

<400>  178

Gly Tyr Ser Tyr Ser Ser Thr Leu 
1               5               


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 that binds MUC16

<400>  179

Thr Leu Gly Met Gly Val Gly 
1               5           


<210>  180
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 that binds MUC16

<400>  180

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      


<210>  181
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 that binds MUC16

<400>  181

Ile Gly Thr Ala Gln Ala Thr Asp Ala Leu Asp Tyr 
1               5                   10          


<210>  182
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 that binds FOLR

<400>  182

Lys Ala Ser Gln Ser Val Ser Phe Ala Gly Thr Ser Leu Met His 
1               5                   10                  15  


<210>  183
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 that binds FOLR

<400>  183

Arg Ala Ser Asn Leu Glu Ala 
1               5           


<210>  184
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 that binds FOLR

<400>  184

Gln Gln Ser Arg Glu Tyr Pro Tyr Thr 
1               5                   


<210>  185
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 that binds FOLR

<400>  185

Gly Tyr Phe Met Asn 
1               5   


<210>  186
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 that binds FOLR

<400>  186

Arg Ile His Pro Tyr Asp Gly Asp Thr Phe Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 that binds FOLR

<400>  187

Tyr Asp Gly Ser Arg Ala Met Asp Tyr 
1               5                   


<210>  188
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable heavy chain of Amatuximab

<400>  188

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Ser Gly 
            100                 105                 110         


Thr Pro Val Thr Val Ser Ser 
        115                 


<210>  189
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable light chain of Amatuximab

<400>  189

Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu 
65                  70                  75                  80  


Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Lys His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  190
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of Amatuximab

<400>  190

Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
1               5                   10  


<210>  191
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of Amatuximab

<400>  191

Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln 
1               5                   10              


<210>  192
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of Amatuximab

<400>  192

Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr 
1               5                   10  


<210>  193
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of Amatuximab

<400>  193

Ser Ala Ser Ser Ser Val Ser Tyr Met 
1               5                   


<210>  194
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of Amatuximab

<400>  194

Gln Gln Trp Ser Lys His Pro Leu Thr 
1               5                   


<210>  195
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  195

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  196
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xpress tag

<400>  196

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  197
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Calmodulin tag

<400>  197

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  198
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  198

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  199
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  199

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  200
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 1

<400>  200

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  201
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 3

<400>  201

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  202
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP tag

<400>  202

Trp Arg His Pro Gln Phe Gly Gly 
1               5               


<210>  203
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP tag II

<400>  203

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  204
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  204

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  205
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  205

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  206
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  206

Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
1               5                   10                  15      


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            20                  25                  30          


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        35                  40                  45              


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  207
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB cytoplasmic domain

<400>  207

Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40              


<210>  208
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB cytoplasmic domain

<400>  208

Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
1               5                   10                  15      


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
            20                  25                  30          


Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        35                  40      


<210>  209
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Transmembrane domain

<400>  209

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            20                  25          


<210>  210
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Transmembrane domain

<400>  210

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
            20                  25      


<210>  211
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  211

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro Gly Ala Ser Gly 
            20                  25      


<210>  212
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  212

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  213
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A

<400>  213

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro Pro 
            20                  


<210>  214
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A

<400>  214

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  215
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 linker

<400>  215

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
1               5                   10      


